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Longtime Nevada Republican files complaint against GOP congressional candidate
The Federal Election Commission complaint against David Flippo cites reporting on his personal finances and campaign finance reports, and calls for an investigation.
Cane-Champ-Puck-Stormy-Whaler-credit-Museum-of-Life-Science-2048x1536.jpg
Endangered red wolf pups Cane, Champ, Puck, Stormy and Whaler prepare for transport from Durham to a new conservation center in New York.
Kenny Atkinson Makes Candid Admission About Mario Hezonja’s Cavaliers Role
Kenny Atkinson says Cleveland is still learning how Mario Hezonja fits and does not want to put the returning NBA veteran in a box.
Cleveland office vacancy hits record high: report
Newmark’s latest report shows the sector ended August with a vacancy rate of 25.2%, which the firm says is an all-time high for the city's core.
Boys Town Nevada to honor Mark Davis at 35th anniversary gala for youth mental health
Boys Town Nevada 35th Gala Honors Mark Davis and Las Vegas youth mental health.
Phoenix among best markets for small business expansion
Phoenix is one of the nation’s stronger markets for small-business expansion, but Tucson is facing a more challenging economic outlook, according to a new study comparing 56 major U.S. metropolitan areas.
Pennsylvania warns of rise in congenital measles and infection during pregnancy
State health officials said that 66 pregnant women have gotten measles since the outbreak began in April.
Predicting Suns' Team Awards for 2026–27 Season
Devin Booker cements his legacy as a franchise icon while rookie sensation Khaman Maluach transforms the frontcourt in this visionary look at the Valley’s future hardware.
Can U.S. Rep. Don Davis beat a gerrymander?
A year ago, Republican state lawmakers redrew North Carolina’s 1st Congressional District to make it more conservative. But as Election Day draws near, incumbent Congressman Don Davis appears to have an increasingly strong shot at keeping his seat.
America’s biggest measles outbreaks have very different death tolls. Why?
Outbreaks in Pennsylvania, South Carolina, Utah, and West Texas have produced dramatically different numbers of deaths.
TENNESSEE VOLS FOOTBALL: Bishop captures national weekly honors
Tennessee senior DeSean Bishop earned two national weekly award honors on Tuesday following his standout performance in the Volunteers' Third Saturday in October rivalry win over No. 6/7 Alabama last Saturday.
The James Webb telescope is watching one of the earliest supernovas in the universe unfold
Astronomers using the James Webb Space Telescope may have discovered a supernova erupting just 1.1 billion years after the Big Bang.
Ana Navarro shuts down ‘View’ cohosts for joking during tense Donald Trump discussion topic
Ana Navarro shut down ‘The View’ cohosts Sara Haines and Alyssa Farah Griffin for making light of a serious, tense topic related to Donald Trump: ‘Stop, this is not funny.’
Vernon County expands support for small businesses through grant program
15 Vernon County businesses have been awarded $10,000 each through the 2026 Elevate Vernon Grant Program.
Vanessa Kerry is the new WHO envoy for health resilience. What's on her to-do list?
A respected figure in the world of global health, Dr. Kerry takes on a new responsibility. She says it's challenging but not "daunting."
Big 12 commissioner talks future of CFP, Protect College Sports Act
What's the future of football conference title games and basketball tournaments? Brett Yormark addressed the effects of postseason expansion at Big 12 media days.
Louis-Ernest Barrias | Nature Unveiling Herself Before Science (1816-1918)
Access all artwork details and all available works by Louis-Ernest Barrias at M.S. Rau
AMD and Microsoft Bring FSR 4.1 to Xbox Series X|S, FSR Diamond Teased for Project Helix
AMD and Microsoft have confirmed that FSR Upscaling 4.1 is coming to the Xbox Series X and Series S. The news came in an AMD video presentation led by Jack Huynh, joined by Xbox CTO Scott Van Vliet and ASUS. The ROG Xbox Ally handhelds are getting it too, and it looks like they will be first in...
Woman killed at Dauphin County business
Woman killed at Dauphin County business | Police looking for suspect
This Horry County healthcare provider just acquired 5 Novant Health clinics. Here’s what to know.
Conway Medical Center has acquired five of Novant Health’s clinics. Here’s where they are and what you should know.
Inside the GOP’s next battle over women’s sports
The Education Department is facing pressure to rescind a policy that’s helped expand women’s athletics — and conservative women leaders are frustrated.
Axena Health Named Finalist for the Digital Health Hub Foundation - Digital Health & AI Awards 2026 at HLTH
NEWTON, Mass., October 20, 2026--Axena Health, Inc. (Axena Health), a women’s health company redefining the standard of care for pelvic health conditions through clinically proven, non-invasive treatments, today announced it has been named a finalist for the Digital Health Hub Foundation – Digital Health & AI Awards 2026 at HLTH. Selected from a pool of more than 1,300 participating companies across all tracks and categories, Axena Health is recognized in the Best in Class Track for Women’s and
First Clade I Mpox case reported in Clark County resident
The Southern Nevada Health District announced Tuesday the first confirmed case of Clade I Mpox in a Clark County resident.
Carrot Top returns to Vegas stage with dark jokes 1 month after suicide attempt
Carrot Top was met with love, cheers, and a standing ovation while returning to his Las Vegas residency one month after his sudden hospitalization.
Philadelphia Union's Cavan Sullivan tops 22 Under 22 Rankings
By Justin Ruderman22 Under 22: Cavan Sullivan tops 2026 rankingsAmid a breakout 2026 season, Philadelphia Union midfielder Cavan Sullivan has secured the No. 1 spot on the annual MLS 22 Under 22 ranki...
Lahn raises more, but Sand holds cash advantage in Iowa governor’s race
New campaign finance reports show Republican Zach Lahn received more money from national political groups, while Sand spent more as the campaigns’ combined spending topped $46 million.
Essentia Health hosting joint-replacement seminar in Fargo
Essentia Health on Tuesday, Oct. 27, will host a seminar in Fargo highlighting available surgical options for joint replacement.
Guardant Health to Highlight Advances in Liquid Biopsy for Cancer Monitoring at ESMO 2026
Guardant Health and partners will present 25 abstracts on liquid biopsy advances for cancer monitoring at ESMO 2026.
Walk-in mammograms at Turning Stone Casino clinic
Walk-in mammogram screenings are now available at Rome Health Convenient Care at the Turning Stone Resort and Casino in Verona on Mondays and Tuesdays, according to hospital officials.
The surprising conservative backlash against Justice Alito
The Republican justice’s new book has convinced many of his political allies that he’s not entirely on the level.
Disney stars Dylan and Cole Sprouse are ‘children of incest’
Dylan Sprouse revealed how he discovered that he and twin brother Cole Sprouse are ‘children of incest,’ due to a wild family history for the ‘Suite Life of Zack and Cody’ stars.
Starbucks Just Ruled Out Buying Chipotle. Small-Business Owners Should Take Notice
Starbucks’ turnaround offers small business owners a powerful lesson: communicate your value to customers before changing your price.
Video. Reaching for the Starmus: Science and music festival back in Tenerife
Video. Mixing Nobel prize-winners, astronauts and artists, the Starmus Festival has been uniting key figures over the past decade at one event to spark creativity, curiosity and a greater understanding of the universe. Its co-founder, Garik Israelian says its all about inspiring the next generation.
Cleveland Cavaliers season preview: Opening schedule, win projection and what to know for 2026-27
TAMS Names Joel Hanson as Executive Director
Executive previously led global innovation business development for CWT
Feeling overstimulated in public? Mental health experts share the strategies that work in any situation
Sensory overload can hit in a grocery store, on a commute or at a crowded party. Here's what therapists and a Harvard psychiatrist recommend, including a few products worth keeping in your bag.
Now open in South Asheville, Novant Health launches new mammography mobile unit
Novant Health has launched a mobile mammography unit, bringing breast cancer screenings directly to Western North Carolina communities.
JD Vance declines to endorse Netanyahu for reelection, says he's focusing on midterms
“I endorse American candidates, and that’s where I’m focused on the midterms,” Vice President JD Vance said.
Tips for covering Medicare open enrollment
It's that time of year again when traditional Medicare enrollees can change their Part D prescription drug plan, move from a Medicare Advantage plan back to original Medicare, and in a handful of states, switch Medigap plans.
11 PS Plus Extra Game Removals for November 2026 Confirmed
Rockstar drops PS Plus support again
'Yaga' isn't the show Hudson Williams fans want it to be
Hudson Williams (of "Heated Rivalry," of course!) stars in this folklore reimagining.
Green Science Alliance opens Swiss battery recycling lab
The Japanese chemical and greentech firm has opened a battery recycling laboratory at the Switzerland Innovation Park Biel/Bienne (SIPBB) in the canton of
A Delivery Robot Caught My Eye in Miami. Here's What It Revealed About the Future of Business
Delivery robots reveal how AI-driven innovation can transform customer experiences, unlock revenue opportunities, and help businesses grow.
DHR Health Expands Behavioral Health Team with Dr. Alexandra Treviño, Psychiatrist
DHR Health, the largest provider of specialty healthcare in the Rio Grande Valley, is pleased to announce that Dr. Alexandra Treviño, has joined its team of physicians.
Codie Sanchez Says a 2-Week Vacation Reveals Whether You Own a Business or Just Work for One. I Disappeared for a Year. Here's What Happened
Two weeks tells you about your systems. A year tells you about your people.
Every Mother Counts Board Visits With UAMS Institute for Community Health Innovation, Ignite
Members of the Every Mother Counts Board of Directors recently visited the University of Arkansas for Medical Sciences (UAMS) Institute for Community Health Innovation and Ignite Professional Studies and saw first-hand how community leaders are paving the way to improve maternal health outcomes in Arkansas. Founded by Christy Turlington Burns,…
Shop from Black-owned businesses at this free festival
Celebrate #BlackJoyUnfiltered at Daptoberfest with 150+ Black-owned vendors Oct. 24 at Warren Central High School.
Expanding Iowa State students' poultry knowledge
Dawn Koltes wants to increase Iowa State students’ awareness of the many opportunities available within the poultry industry in Iowa and beyond.
UW-River Falls to offer Halloween carnival and 'Haunted Lab' science demonstrations Oct. 20
Two special Halloween-themed events are planned at the University of Wisconsin-River Falls on Tuesday, Oct. 20, including a Halloween carnival and “Haunted Labs” science demonstrations.
Perceptions of science and scientists shape partisan views on common vaccines
How Americans view science and scientists is strongly associated with whether they think vaccines are safe and effective - and helps explain partisan differences in perceptions of some vaccines, according to a new study led by a team from the Annenberg Public Policy Center (APPC) of the University of Pennsylvania.
T-shirts and silver balls: Politics get mixed in with the profane at a Trump store
By Elle Reeve, Samantha Guff, Frank Fenimore, CNN Boones Mill, Virginia (CNN) — Walk into Trump Town USA in Boones Mill, Virginia, and you may marvel at the breadth of human creativity, as long as you’re not distracted by how the merchandise tackles some of the most controversial political issues in the most vulgar way
Medical Center Chief Communications Officer John Howser to retire
Howser, the Medical Center’s communications leader since 2012, will retire in March 2027 after nearly 40 years at Vanderbilt.
What enjoying the journey has taught me: Olivia Arnold
CSU Assistant Professor Olivia Arnold discusses the value of being open to new experiences and her passion for teaching undergraduates.
Two longtime rivals seek new audiences in Oregon governor’s race. Who will persuade voters?
Despite the effective rematch from 2022, this year’s campaign trail has pushed both candidates to reach voters in opposing ideological lanes.
Chinese scientists find neurons may act as minicomputers to help decision-making
Researchers find evidence that suggests neural activity can guide the way the brain adapts to different sensory experiences.
Antigravity's Follow Me Bundle Adds Accurate Tracking And Gesture Controls To Its A1 Drone
Antigravity's watch and ring remote are available as an accessory bundle or as a full kit with the A1 drone.
Seattle Art Museum renovations: Peek inside at construction
An $8.1 million project is underway at Seattle’s flagship art museum, adding more public spaces to gather, work and dine at the museum. Take a peek!
L'Oréal USA Names 2026 For Women in Science Awardees, Supporting the Future of Scientific Discovery
/PRNewswire/ -- Today, L'Oréal USA announced the 2026 For Women in Science (FWIS) awardees, providing five women postdoctoral scientists grants to advance...
WSU professor Felix Lankester elected to National Academy of Medicine
Lankester’s pioneering work on vaccine delivery and community-based vaccination programs has helped transform rabies prevention and save lives in low-income countries.
Silicon Valley GTM and Business Development Veteran Dylan Gittleman Joins Dialogica's Founding Sales Team
/PRNewswire/ -- Dialogica ("Dia"), the voice-first AI secretary for the world's top law firms, today announced that Silicon Valley go-to-market business...
Council leader to stand down after health scares
Labour's Tudor Evans said it was time to "put health and family first" after 38 years in politics.
Indian scientists identify Martian analogue sites
Kerala researchers identify Martian analogue sites in Tamil Nadu and Atacama Desert via hydrous sulfates, aiding Mars paleoenvironments study.
New Book Includes Previously Unreleased Interviews By Edward Gorey
For ardent Edward Gorey fans there’s a new book available, “Memento Gorey: The Last Interviews with Edward Gorey” by Chatham filmmaker and documentarian Christopher Seufert, published by Schiffer Publishing with
Could AI Use a Simple Photo of Your Face to Reveal Clues About Your Health?
A new AI model can estimate biological age and predict cancer survival outcomes using a simple photo of a patient’s face, though more research is needed before doctors will be able to use it to help them decide on treatments.
Are partisan politics even changing up our accents? They just might be, y’all
Vowels have become the latest players in partisan politics, a barometer of how beliefs and values fit within the old vs. new South.
Cristante called up for Roma-Slovan clash
A draw against Fenerbahce and a defeat against Real Madrid. Roma’s Champions League tally needs to be increased as soon as possible. To do so, a victory will be crucial in tonight’s match at the O...
KFF Tracking Poll on Health Information and Trust: Fall 2026 Update on Vaccine Views
The latest KFF Tracking Poll on Health Information and Trust finds about half of parents mistakenly believe spacing out vaccines is healthier for children, while confidence in many long-standing childhood vaccines is high across partisans. These findings take on new relevance following President Trump's recent executive order calling for changes in U.S. childhood vaccine recommendations, including splitting the measles, mumps, and rubella (MMR) vaccine—currently given as a single combined shot—into three separate vaccines across multiple visits.
Michigan State Gets Stunning Quarterback News Ahead of UCLA Showdown
Michigan State will face a different UCLA offense Saturday after quarterback Nico Iamaleava suffered a severe knee injury. Here's what his absence means for the Spartans.
CAS collaborates with Microsoft to enable faster innovation in pharmaceutical, life sciences, and chemical industries
/PRNewswire/ -- CAS, a division of the American Chemical Society, today announced the availability of CAS Connections in Microsoft Copilot. The connector gives...
Scientists finally uncover why statins can cause muscle pain
Scientists have uncovered a surprising reason why statins, the widely prescribed cholesterol-lowering drugs that help prevent heart attacks and strokes, can sometimes cause muscle pain, weakness, and even severe muscle damage. Using advanced imaging technology, researchers discovered that statins can attach to a crucial protein in muscle cells and force open a channel that normally controls calcium flow. This causes calcium to leak continuously, potentially damaging muscle tissue.
Tecsys delivers AI capabilities to help health systems anticipate and act on pharmacy and supply chain risks
/PRNewswire/ -- Tecsys Inc. (TSX: TCS), an industry-leading supply chain management company, today announced the availability of AI solutions that help health...
How much is DeForest Buckner worth on the trade market?
DeForest Buckner is still one of the Colts’ best defensive players, but age and his contract complicate his trade value.
Christina Applegate Reveals She Was Misdiagnosed With MS: ‘I’m Back at Square One’ and It’s a ‘Mindf—’
Christina Applegate returned to her podcast, “MeSsy,” on Tuesday with some shocking news: She was misdiagnosed with multiple sclerosis. After taking a break from the podcast for seven months due to he...
Sponsored Content: HMG Health Matters: A Surgeon's Perspective on Breast Cancer
Dr. Cheryl Stanski, General Surgeon and Vice President of Holston Medical Group tells us what she wants every woman to know about breast cancer. She talks about the success rate, the hope, and the options now available for women. For more information and to read more please visit the Health Matters blog at HolstonMedicalGroup.com.
Tennessee health departments providing free flu vaccines Tuesday
TRI-CITIES, Tenn. (WJHL) — Health departments across the Northeast Tennessee region are offering free influenza vaccines on Tuesday as part of a statewide annual “Fight Flu” prevention …
JFK’s mistresses recall their ‘irresistible’ and ‘solicitous’ affairs with the president in new book
Laurence Leamer’s latest book, “Ladies Man: The Careless Heart of John F. Kennedy,” is available for purchase wherever books are sold.
'We used to go to the climate conferences together. We are not anymore': ESA official Simonetta Cheli tells us how the political landscape for Earth observation is changing
Live Science sat down with the European Space Agency's Simonetta Cheli to discuss the importance of Earth observation, how NASA budget cuts have changed the picture, and how the proliferation of private satellites could hinder our ability to view the planet.
'It makes me feel that we can do a lot about it': ESA official shares striking satellite snap of Europe's record-breaking summer heat waves
The head of ESA's Earth observation program tells Live Science why a striking image of a recent heat wave scorching Southern Europe gives her hope that we can properly monitor — and eventually prevent — similar extreme weather events in the future.
Brightstar Capital Partners Invests in Material Handling Group, a Technician-Led Provider of Material Handling Equipment and Aftermarket Services
CANTON, Mich. & NEW YORK, October 20, 2026--Brightstar Capital Partners ("Brightstar"), a private equity firm focused on partnering with founders, entrepreneurs, and management teams, has acquired a majority interest in Material Handling Group USA ("MHG" or the "Company"). Financial terms were not disclosed. MHG is a technician-led provider of new, used, and rental material handling equipment and aftermarket parts and service, serving customers across Michigan, New York, and the Mid-Atlantic reg
2026 Business & Economic Outlook to Explore Key Trends
The Northwest Indiana Business RoundTable ( NWIBRT ) and the Construction Advancement Foundation ( CAF ) will host the 2026 Business & Economic Outlook on Oct. 30, bringing business leaders, …
A note to readers: Science, accountability and elections
Dear readers, As early voting begins, I wanted to share some news — and why it connects to the decisions we make at the ballot box. I’ve been selected for the inaugural cohort of the South Atlantic Climate Journalism Hub mentorship program, hosted by Covering Climate Now. I’m excited to join this group, learn from scientists and fellow journalists, and expand my science reporting. Science directly ties to governance. Local officials make decisions about where development goes, how infrastructure is maintained, what emergency preparations receive funding, and how communities rebuild after disasters. Understanding the evidence behind those decisions helps us evaluate whether our government is serving us well. Here in western North Carolina, those connections are all around us, in Lake Lure and beyond. Flood maps inform decisions about property and development. Engineering assessments help identify risks at dams and bridges. Rainfall forecasts guide emergency preparations. Geological information helps explain landslide hazards. Water testing gives communities information they need to assess conditions. Meteorologists’ knowledge and public perception of weather events shape public safety. Each involves scientific or technical knowledge. Each also raises questions about public responsibility: What did officials know? How did they use that information? What did they tell the public? What did taxpayers receive for their money? A study can identify a problem. Elected officials still have to decide what to do about it, how to pay for it, and how to explain their choices. Reporting should examine both the evidence and the response. That is where I want to strengthen my work. My reporting on Helene recovery, infrastructure, flooding, public safety, and public spending has repeatedly brought me to questions that require scientific expertise alongside public records. This mentorship may help me better understand the research, ask more precise questions, and explain the answers clearly. I also bring the perspective of someone living with these concerns. I live downstream of Lake Lure Dam, and landslides affected my property during Helene. Those experiences bring urgency to my questions. Careful reporting helps establish the answers. Readers deserve to know what the evidence shows, where uncertainty remains, and whether officials accurately describe the information guiding their decisions. You also deserve scrutiny of proposed solutions: what they cost, what they are expected to accomplish, and what risks remain. Access to that information matters. As a mostly deaf journalist who relies on written communication, I will continue pressing for written public warnings, records, and explanations that people can read and use in real time. As you consider the candidates seeking your vote, consider how they approach evidence, preparedness, and transparency. Do they support local journalism, even when it’s not parroting a press release? Do they explain weather events clearly in plain English and explain their decisions after them? Make supporting records available? Acknowledge uncertainty? Follow through when a report identifies a risk? Those are practical questions about governing. Thank you for supporting Cops & Congress and the work that makes these questions part of the public conversation. I’m grateful to David Dickson and the CC Now team for this opportunity, and I look forward to bringing what I learn back to you. Annie DanceEditor & Publisher, Cops & Congress — Learn more about this newsletter, ethics policy, how you can help shape this work, and support it. Follow on X and Facebook. Send constructive criticism, fan mail, and tips with public documents for future stories: CopsandCongress@gmail.com ICYMI: View the Cops & Congress archive — Annie Dance is the publisher of Cops & Congress, a newsletter that analyzes what happens when crime, courts, disaster, democracy, and small-town policies collide. Views expressed here are covered by the First Amendment. Dance has a Bachelor of Arts from Manhattan University in Communication with a focus in Journalism and Government. She has been a journalist for over 20 years. Share Upgrade now or give a gift subscription
Bungie plans to share first details about surprise 'unvaulting' of Destiny 2 content soon
We should learn more about Bungie's 'unvaulting' of previously removed Destiny 2 content very soon.
Kratos Would Have Had a Different Name Were It Not for Relentless Domino's Pizza Jokes, God of War Creator Reveals
God of War's Kratos almost went by a different name, but developers at Santa Monica Studio made too many Domino's pizza jokes.
Disney Names Carol Choi Asia Pacific President as Luke Kang Retires
Disney names Carol Choi Asia Pacific president as Luke Kang retires after 16 years, effective Dec. 1.
What Andy Dalton signing means for the Falcons' QB situation
How will Andy Dalton signing affect Falcons QB Tua Tagovailoa?
Scientists get funding to tackle 'biosecurity threat'
A University of Surrey team is helping develop a vaccine against a bacteria affecting poultry.
As Science and Technology Advance, Nurses Become More Essential to Successful Organ Transplants
Symposium of articles examines how innovations in organ donation and transplantation reinforce the vital role for critical care nurses and advanced practice nurses throughout the continuum of care for donors, candidates awaiting transplantation, recipients and their respective families.
Former campaign worker says she fended off advance by future NC insurance chief
The woman told FBI agents she quit Mike Causey’s campaign after he kissed her without provocation.
South Florida is pivoting from tourism to national biz hub
Carnegie Mellon, Vanderbilt join companies opening campuses and offices in South Florida as it pivots from tourism to being a national business hub
Review: Castlevania: Belmont's Curse (Switch) - A Pro-Grade Metroidvania With A Stiff Learning Curve
This time it's war
GDC Festival of Gaming 2027 moves to four-day format to "create a higher quality, more focused and valuable experience"
"We're concentrating programming and opportunities during the days when the community is most active," say organisers
Tom Fontana Boards Vatican Series Based on 'Devil's Business' Book
"Oz" creator Tom Fontana is set to create and showrun a new Vatican drama series based on Emanuele Midolo’s forthcoming novel "The Devil's Business."
‘Oz’ Creator Tom Fontana to Showrun Vatican Drama Series Based on ‘The Devil’s Business’ Book as Fabel Entertainment Scores Rights (EXCLUSIVE)
“Oz” creator Tom Fontana is set to create and showrun a new Vatican drama series based on Emanuele Midolo’s forthcoming novel “The Devil’s Business” after Fabel Entertainment scored book rights. “The ...
Tom Fontana Boards Vatican Series Based on 'Devil's Business' Book
"Oz" creator Tom Fontana is set to create and showrun a new Vatican drama series based on Emanuele Midolo’s forthcoming novel "The Devil's Business."
ARK Invest Bets One Business Can Lift Tesla Stock to $4,400
ARK Invest’s open-source model values Tesla at about $4,400 per share in 2031, with robotaxis at 80% of enterprise value.
Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)