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Scientists found two bat species never known to science in Cameroon’s rainforest after studying bats that looked almost identical
Deep inside the rainforests of southeastern Cameroon, scientists have identified two bat species that had never been formally recognised by science. The discoveries came from surveys in and around Lobéké National Park and the Dja Biosphere Reserve, where researchers examined a small collection of forest bats belonging to the genus Glauconycteris.
Korea freezes 2027 health insurance premium at 7.19%
The government has decided to freeze the national health insurance premium rate at 7.19 percent in 2027, citing stable finances and expected support from the government and premium revenue.The Ministry of Health and Welfare said that the Health Insurance Policy Deliberation Committee approved the 20
How hurricanes triggered lizards' rapid evolution
Hurricane season is upon us and it turns out that these powerful storms can quickly affect the biology of animals. After hurricanes Irma and Maria hit the islands that make up Turks and Caicos about a decade ago, the silver key anole adapted. They now have a shorter fourth toe on their hind legs! That could help them cling to objects better. But how do you know unless you put lizards in front of a fan and record how long they can hold on?This study is out now in the journal Current Biology.Interested in more science in the news? Email us your question at shortwave@npr.org.Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s perks include sponsor-free listening. Learn more at plus.npr.org.
Ribbon Bio Appoints Jay Therrien as Chief Business Officer
Cell-free DNA assembly pioneer, Ribbon Bio, has today announced the appointment of Jay Therrien as Chief Business Officer. Therrien joins Ribbon's executive leadership team where he will lead the company's commercial strategy and growth initiatives.
CSU biology professor delivers talk on extremophilic microorganisms, research advancements
Thomas Santangelo began the department of biology’s fall semester seminar series at Colorado State University strong, presenting the progressive research behind microorganisms in extreme environments and how those observations can inform future research about biological resilience and adaptation. Santangelo, a professor of biochemistry and molecular biology at CSU, was the main speaker of the “Surprises...
GenSight Biologics Provides September 2026 Business Updates
PARIS, September 08, 2026--Regulatory News: GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today provided business updates covering the summer of 2026 and confirmed the publication date for the Company’s financial statement covering the first half of 2026.
4 CDMOs to consider when outsourcing manufacturing
Contract development and manufacturing organizations looking to do business with biopharmas include Lonza, which has more than 30 sites, and Samsung Biologics, which recently announced a planned acquisition of another CDMO.
Perilla frutescens Benefits: Effects on Allergy, Inflammation, Immunity, and Gut Health
Perilla frutescens contains phenolic acids, flavonoids, and other bioactive compounds that show anti-allergic, immunomodulatory, anti-inflammatory, and gut-protective effects across laboratory and animal studies. Limited human evidence, including a small randomized trial of rosmarinic-acid-enriched Perilla extract for seasonal allergic rhinoconjunctivitis, is promising, but larger standardized clinical trials are needed.
Fired DeSantis campaign staffer Nate Hochman lands senior State Department role under Marco Rubio
Former DeSantis staffer rebounds into senior Rubio State Department role.
Why Scientists Asked More Than 1,000 People to Bury Their Underwear to Study Soil Biodiversity Across Switzerland
More than 1,000 volunteers buried cotton underwear across Switzerland to help scientists study soil biodiversity and biological activity.
Democrats Condemn NIH-DOD Research Agreement
The Defense Department could tap up to $2 billion in federal research dollars designated for biomedical research, under an agreement signed with the National Institutes of Health.
Small bowel microbiome offers clues to women's health
A new study by investigators at Cedars-Sinai Health Sciences University has identified differences in the makeup and organization of the small bowel microbiome between women and men. The findings, published ...
Scientists covered 200 square metres of a Swiss glacier with sheep’s wool; early tests found it protected the ice about as well as plastic sheets, but only 0.02% of Swiss glacier ice is covered
A natural wool covering placed over 200 square metres of high-altitude Alpine ice has proved as effective at slowing summer melting as conventional synthetic tarpaulins, offering a possible biodegradable alternative to plastic sheets. Initial results from the "Keep It Wool" trial on the Tsanfleuron Glacier in western Switzerland show that prototype wool blankets protected snow and ice from heat about as well as plastic geotextiles.
Scientists Discover Soil Bacteria Enzyme that Breaks Down Both Plastic and Antibiotics
Biologists studying how bacteria break down a new generation of plant-based bioplastics -- long-chain aliphatic polyesters -- have discovered an enzyme that can dismantle both plastic and antibiotics.
Minecraft's next update is called Wilderness Bound
After teasing a new biome and treasure-filled camps during Minecraft Live 2026, this upcoming update finally has a name: Wilderness Bound.
Serie A: Cagliari vs. Lecce
Fabio Pisacane and Eusebio Di Francesco have confirmed their selections as Cagliari host Lecce at the Unipol Domus in the penultimate match in the third round of 2026-27 Serie A fixtures.Cagliari have...
Robert Pattinson responds to Chris Hansen’s ‘Primetime’ casting criticism
Robert Pattinson addresses Chris Hansen’s ‘Primetime’ casting criticism after former ‘To Catch a Predator’ host named the actor he would have chosen to portray him in a biopic.
The bioinformatics escape room where guests become genetic detectives
A Northeastern professor created a bioinformatics escape room to introduce newcomers to a growing career field.
The best new popular science books of September 2026 include new titles by Carlo Rovelli and Xand van Tulleken
Dive into new titles from major names including Carlo Rovelli, Maggie Aderin, Xand van Tulleken and Jim Al-Khalili, as well as a new biography of Stephen Hawking
Protein Pop launches 15 g protein and prebiotic soda for gut health
Rise Wellness has expanded its Protein Pop range with a zero-sugar sparkling beverage combining whey protein, collagen and five grams of fibre
A Shared Biology Underlies 5 Major Fatigue-Causing Illnesses, Scientists Suggest
“A biological unifying theory of fatigue.”
Prof Elizabeth Streicher unravels the science behind drug-resistant TB
Prof Elizabeth Streicher of the Division of Molecular Biology and Human Genetics delivered her inaugural lecture on Tuesday 1 September 2026. Her research focuses on the transmission and spread of Tuberculosis (TB). Knowing where TB transmission is happening can help to stop it from spreading. Prof Elizabeth Streicher of the Division of Molecular Biology and Human Genetics in the Faculty of Medicine and Health Sciences delivered her inaugural lecture on Tuesday 1 September 2026. The title of her lecture was Decoding tuberculosis: the evolution of technology, epidemiology and the Mycobacterium tuberculosis genome. Streicher explained to Corporate Communication and Marketing how molecular epidemiology (using genetic information to track how and why diseases spread through populations) has improved our understanding of where drug-resistant TB comes from, how it spreads and how drug resistance evolves within and between populations. Tell us more about your research and why you became interested in this specific field. Overall, our research group studies the genome (complete set of DNA instructions found in a cell) of Mycobacterium tuberculosis, the bacteria that cause tuberculosis (TB) disease. Various regions of the genome are interrogated to study different aspects of the disease. My main focus has been on the epidemiology of tuberculosis – how the bacteria’s genome changes over time and what this tells us about the transmission and spread of the disease. How would you describe the relevance of your work? If we understand how the bacteria that cause TB change and spread, it can assist in combating TB globally. How has molecular epidemiology helped improve our understanding of drug-resistant TB? Molecular epidemiology was very important in drug-resistant TB as it was originally believed that bacteria that become resistant to antibiotics would be less fit and not be able to transmit. But it was shown that they can transmit, and therefore have to be monitored to identify hotspots of transmission and outbreaks, etc. Can you tell us briefly about the spoligotyping technique and its advantages for studying drug-resistant TB? Spoligotyping (a molecular technique used to identify and track specific strains of TB bacteria) does not detect drug resistance, but since the technique is relatively quick to do, it can be very useful in real-time situations, e.g. to monitor outbreaks of drug resistance. Why are interrupting transmission chains and identifying genomic hotspots important for controlling the spread of TB? Knowing where TB transmission is happening can assist in allocating resources to those areas to stop future transmission and spread of TB. Higher education can be challenging. What keeps you motivated when things get tough? Students – how they are so passionate and dedicated to learning and contributing to research and society as a whole. What aspects of your work do you enjoy the most? Again, the students and colleagues! But also the fact that it is continuously changing and thereby we are learning and expanding our knowledge. In the end, I know that we contribute to a better society in our small way. Tell us something exciting about yourself that people would not expect. Even though I love hiking (day and multi-day hikes) and being outside, I really do not like camping! How do you spend your free time? I love hiking (wellbeing in nature) and like to watch most sports. ©Higher Education Media Services. Subscribe
Early Data Indicates an A.I.-Generated Drug Could Slow Aging
Artificial intelligence was used to help develop a drug candidate, rentosertib, for a rare lung condition. Its maker says the drug also seems to reduce the biological hallmarks of age.
Capello: Why Roma can challenge Inter for Serie A title
Fabio Capello feels Roma can pose a strong challenge to Inter for the 2026-27 Serie A title: ‘When you have quality players in the final third, anything can happen.’Inter and Roma are the only two...
Capello lauds Roma: “They’re the true anti-Inter.”
Fabio Capello believes in Gian Piero Gasperini’s Roma. The former Giallorossi coach, interviewed by Gasport, identified the Roman team as Inter’s main rival in the Scudetto race, focusing on the s...
Slegers praises debutants in victory at Brighton & Hove Albion
Arsenal head coach Renée Slegers praised her summer signings after The Gunners claimed a 1-0 victory over Brighton & Hove Albion at Broadfield Stadium on Sunday afternoon.A 10th-minute goal for debut...
SEERS’ AI-powered wearable ECG monitor wins Health Canada approval
SEERS, a wearable AI diagnostic monitoring company, said Monday that its AI-powered wearable electrocardiogram analysis solution mobiCARE has received a Class II Medical Device Licence (MDL) from Health Canada.Health Canada granted the licence last Thursday (local time), following an application sub
Cuba: US Embassy issues health alert due to GI pathogens like norovirus, Shigella
The US Embassy in Havana issued a health alert last week after seeing a significant increase in diarrheal illness across Cuba, associated with the continuing degradation of the water and energy infrastructure. This degradation affects water supply, and food storage and temperature control. Recent cases have included E. coli, norovirus, Shigella, and other gastrointestinal pathogens. This comes after a health alert dated August 28 which noted that Cuba’s water delivery infrastructure is increasingly unstable. The Embassy is aware of reports of residential neighborhoods that have gone for long periods without receiving water from municipal or public sources. Dengue cases surge in the Tampa Bay area Prolonged and worsening water issues and power outages caused by the regime’s mismanagement of public infrastructure impact the entire island. Water often only flows to residences when city power is on for a sufficient amount of time. Media reports indicate wells are running dry across the country due to drought, aggravating the ability to supplement water delivery. The lack of water, coupled with power shortages that have disrupted cold chain networks, can present significant health and safety challenges. We remind U.S. citizens to be aware of the risks when traveling to Cuba and take precautions. Embassy officials offer the following precautions to prevent illnesses: Avoiding Foodborne Illness: Be cautious of meat, poultry, seafood, eggs, dairy, and other perishable foods that may have been inadequately stored. Avoid foods that appear to have been sitting at room temperature for extended periods. Avoid raw or improperly washed vegetables. Be cautious of food cooked and then cooled, stored, or reheated, as improper temperature control can allow pathogens or toxins to develop. Wash hands thoroughly with soap and water before eating and after using the restroom. Hand sanitizer may be less effective against certain gastrointestinal pathogens, including norovirus. Outbreak News Today is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Water Safety: Use only water known to be safe for drinking, brushing teeth, making ice, and cooking. Use bottled or appropriately treated water; check that bottle seals are intact before opening. Avoid ice unless the water source is known to be safe. Do not use untreated tap water to prepare beverages or food. Be aware that contamination can occur when food, utensils, and surfaces are washed with contaminated water. If You Become Ill: Stay hydrated, especially with frequent diarrhea or vomiting. Most illnesses are self-limited and improve within several days. Seek medical attention for persistent or severe diarrhea, bloody stools, high fever, significant abdominal pain, repeated vomiting, signs of dehydration, or symptoms not improving. Common medications (e.g., acetaminophen, ibuprofen, antibiotics) are frequently unavailable in Cuba; consider bringing your own supply. If you like the reporting on Outbreak News Today, please consider a paid subscription for $5/month or $30 a year. Help support the cause of this niche journalism. It is appreciated.
The science behind the beauty business
Some of Europe’s industrial champions may be in retreat, but its cosmetics sector remains a global leader, buoyed by healthy demand, recognised brands and a reputation for innovation."The fact is, the science in cosmetics is better here in Europe than anywhere else in the world,” says Pierre Morvan, CEO of Technature, a private label cosmetics manufacturer located near Brest in France’s northwestern Brittany region. “You have to have good science in order to make the difference, and that is why we invest so much in research and innovation.”Across Europe, the beauty and skincare products sector supports an estimated 3.6 million jobs, including 265,000 employed directly in the industry, according to the Cosmetics Europe trade group.. Cosmetics production contributes an estimated €11 billion to the EU economy, and generated €30 billion in export revenue last year, a €400 million rise from 2024.Technature itself has a global footprint, supplying products for 1,500 brands in 65 countries. Its range of skin gels, facial masks, nail treatments and other products include natural ingredients and extracts derived from plants, such as seaweed, that are developed and refined through science-based analysis and testing.While industry projections point to sustained growth for the foreseeable future, driven by emerging economies and wider availability of exclusive brands that were once chiefly sold by high street retailers, the sector is not immune to the impact of geopolitics and trade wars. The Trump Administration’s tariff threats have dented cosmetics exports to the EU industry's largest overseas market. After the European Parliament approved the EU-US Turnberry Agreement in June, setting a 15% levy on many EU goods, the French Federation of Beauty Companies warned that “exports are falling sharply” and urged the EU to negotiate an opt-out for cosmetics.Technature’s CEO flags South Korea as an emerging competitor, partly due to its assertive marketing efforts. “I would have to say I am a little bit scared,” Morvan says, regarding the growth potential of the South Korean cosmetics industry. “This is why science and innovation are so important if Europe is to remain the leader.”With a workforce of 200, including biologists, chemists and other scientists, around 15% of Technature’s staff work in three research and development (R&D) labs. A similar number work in four quality control and assurance facilities, where science plays a crucial in ensuring product safety in a sector that is subject to the European Cosmetics Regulation.Educational exchange between industry and academiaIn recognition of Technature’s research and innovation, Morvan was selected as one of Brest’s ambassadors to Science Comes to Town (SCTT), a European initiative to strengthen communications and understanding between science and society. Brest is one of three coastal cities in the EU-funded programme, alongside Split (in Croatia) and Kiel (in Germany). From 7-11 September, Brest will host the EU TalentOn contest featuring 100 early-career researchers from across Europe.Morvan appreciates the value of engagement with educational and scientific institutions as well as the home community. For instance, Technature collaborates closely with university partners to enhance its in-house R&D. In addition, it invites students to its labs and sends its own researchers to local institutions. "We absolutely want the students to know what the industry is all about,” Morvan says, noting that seeing science in action can help young people “understand that they can do something real with science, to create something with what they are learning.” He says another important benefit: encouraging new generations of young people to consider a career in cosmetics.Community involvement also raises awareness about Technature and the skincare industry as a whole. “The public gains recognition of the innovative company that we are, and this is important for getting new customers,” Morvan says. One of its recent innovations — tiny, colourful cosmetic pearls that release skin moisturisers on application — was showcased at this year’s VivaTech event in Paris.Morvan holds a master's degree from the Brest Business School and studied animal production and biology in Brest at the University of Western Brittany (UBO), an SCTT partner, and at the University of Tours. He got his start in business in 2002, initially working on using seaweed as a raw material in the food industry before transitioning to cosmetics. Morvan has always been interested in connecting science and business, reflecting one the goals of SCTT to enhance public-private collaboration.The invitation to participate in SCTT was unexpected. “It was a surprise to get a call from the city of Brest saying that they wanted me on this programme,” Morvan recalls, adding that officials were drawn by his company’s R&D. “It's not only theory and science fundamentals. Our science is something that is applicable to the global market — and important for the community.”Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.
Merrimack Anheuser-Busch Property purchased by United Therapeutics Corporation
Biotechnology firm United Therapeutics Corporation has acquired the former Anheuser-Busch brewery site in Merrimack for $47 million, according to sources familiar with the matter. The transaction secures one of Southern New Hampshire’s largest industrial parcels, spanning nearly 300 acres off Daniel Webster Highway
In 2019, scientists shut off rain inside Arizona’s Biosphere 2 rainforest for 9.5 weeks; carbon storage fell about 70% before the forest recovered
Researchers turned off the water supply to the tropical rainforest inside Arizona's Biosphere 2 in 2019, and watched the ecosystem respond to an artificial drought. The experiment lasted four months in total, which included the recovery period, while the forest itself went without rain for about 9.5 weeks.
In 1996, Columbia scientists shifted Biosphere 2’s 2.6-million-gallon Arizona ocean between ice age, modern and future CO₂ every 3 months; future chemistry cut coral calcification by about 40%
For years, scientists argued about whether it would be safe for the ocean to absorb the carbon dioxide that people release into the atmosphere. When Biosphere 2 began, it was a widely reported experiment in which people lived in confinement to test whether a closed biosphere could support them.
KAIST identifies cause of artifacts in battery nanoscale analysis, paving the way for more reliable measurements
- A research team led by Professors Seungbum Hong and Jong Min Yuk from the Department of Materials Science and Engineering and Professor Nam-Soon Choi from the Department of Chemical and Biomolecular Engineering has identified the cause of a measurement artifact in nanoscale battery analysis that can make surface topography appear to represent ion movement. - The team has developed a method to reduce these artificial signals by smoothing rough battery-material surfaces, potentially improving the accuracy of analyses for next-generation batteries, including conventional lithium-ion batteries and emerging technologies such as sodium-ion and solid-state batteries.
8 Subtle Signs Your Gut Health Might Be Affecting Your Mood, Skin, or Energy
Gut health is linked to so many facets of overall health that you might not even realize which mental and physical signs actually link back to the state of your microbiome. Here are some common and surprising signs of poor gut health, and easy steps to improve your gut health naturally.
Businesses in Grimsby to campaign about derelict buildings
Traders on Cleethorpe Road in Grimsby are demanding action over The Albion and a building opposite.
Mastantuono taken out of Fiorentina’s game at half-time
Franco Mastantuono’s loan spell at Fiorentina is off to a troubling start. The Argentinian was subbed off at halftime in a 2-1 loss at home to Torino, as Fiorentina remain winless and pointless in Serie A. Mastantuono has been starting for his new team, but head coach Fabio Grosso will be forced to make some […]
"Old Person Smell" Is Real, And Science Will Dictate Whether It Happens To You
"That smell is an actual biological phenomenon."
Kenosha car show brings thousands to downtown businesses
Organizers said this year's Kenosha Classic Cruise-In saw record attendance and participants.
San Francisco’s California Academy of Sciences is celebrating the state’s biodiversity with film screenings, community science events, and a nature festival this September
The California Academy of Sciences in Golden Gate Park is hosting various events this September, including a free nature festival.
Gabriel Gudmundsson: I have been waiting for this
Starting for the first time this season in Leeds United’s draw with Brighton & Hove Albion was defender Gabriel Gudmundsson, who was pleased with a point on his return to the team.Jayden Bogle’s f...
Nottingham Forest 0-0 Tottenham: What De Zerbi said
Tottenham Hotspur failed to have a shot on target in a Premier League match for the first time since April 2022 against Brentford under Antonio Conte. Tottenham Hotspur have failed to score in three successive Premier League games for the first time since November 2021, while it is the first time a Roberto De Zerbi side has failed to do so in Europe's big five leagues since Brighton and Hove Albion in January 2024.
Grosso aware Fiorentina could fire him after three defeats
Fabio Grosso recognises he could already be sacked after Fiorentina lost all three Serie A games, falling 2-1 to Torino. ‘That decision is for those above me.’If there were any doubts, it is no un...
Italy’s far-right Vannacci lashes EU in business summit address
By Valentina Za, Elvira Pollina and Francesca Landini CERNOBBIO, Italy, Sept 5 (Reuters) - Italy's rising far-right politician Roberto Vannacci told a high profile business forum on Saturday that the European Union should halt political integration and...
Italy’s far-right Vannacci lashes EU in business summit address
By Valentina Za, Elvira Pollina and Francesca Landini CERNOBBIO, Italy, Sept 5 (Reuters) - Italy's rising far-right politician Roberto Vannacci told a high profile business forum on Saturday that the European Union should halt political integration and...
Could a whale really swallow a human? We asked a biologist.
The new thriller ‘Whalefall’ depicts a diver trapped inside of a sperm whale.
Weak hydrogen bonds dethrone copper as the most stable metal binder, opening a new path for metal selection
- KAIST researchers reversed a decades-old metal-complex stability trend by tuning weak hydrogen bonds around the complexes without altering the metals’ direct coordination environments - The discovery could provide new design strategies for selective metal separation and recognition, catalysis, and biomimetic systems
ADHD UK Cannot Hide the Flawed Science Behind the Diagnosis and Its Treatment
The extensive critique of the biomedical account of ADHD and its treatment with stimulant medication has persisted for decades.
Brighton & Hove Albion vs Leeds United: Match preview
Leeds United head to the South Coast on Saturday afternoon looking to maintain their unbeaten start to the 2026/27 Premier League season, but Daniel Farke’s side face one of their toughest tests yet against a Brighton & Hove Albion side who have already shown just how dangerous they can be in front of goal.
Guardant Health Faces a $245 Million Patent Judgment, But Its Newer Tests Could Offer Protection
Guardant Health, Inc. (NASDAQ:GH) faces a costly legal setback after a US court ordered the cancer-testing company to pay more than $245.2 million in a DNA-sequencing patent dispute. The final judgment upheld a 2023 jury verdict finding that Guardant willfully infringed two DNA-sequencing patents asserted by TwinStrand Biosciences and the University of Washington. The financial […]
15 discouraging hours with Onimusha: Way of the Sword, and 10 brilliant ones with He Who Watches
In the last few weeks, while playing some video games that I might review, I emailed two cries for help. I sent the first to a rep for Capcom, confessing that the company’s samurai game Onimusha Way of the Sword (out today for PC and console) was crushing me. “Feels like I’m playing ‘hard’ mode, not ‘normal,’” I wrote. “And I don’t want to have to knock it down to “story”. I’m exploring, trying to level my gear, but these two-phase boss fights with no mid-fight checkpoints are brutal.” I wagered I was only about halfway through the game, if that. I wasn’t sure I could keep up with the steepening difficulty curve. Was I missing something? Then, on Monday, I took some photos of some puzzles that were baffling me in the mind-bending He Who Watches (out now on PC), wrote out lengthy descriptions of how I’d been trying to solve them and asked Bobby Vanden, the game’s solo developer, for a nudge in the right direction. I told Vanden I’d spent hours on these puzzles. “I’m stuck in triplicate,” I told him. Could he tell me if the solutions I was attempting were even on the right track? I didn’t mention that the puzzles—coupled with major time pressures from other work—were stressing me out so much that playing the game was giving me headaches. This double dose of panic was unusual. I’m used to managing a workload full of reporting and reviewing, used to a crowded schedule and the need to stay calm amid the bustle. But I was stressed about these games. No one was forcing me to review them, nor even play them. I’d simply found them interesting enough to start, hoped they’d be interesting enough to write about and I’d sunk hours into them assuming I’d made the right call. Suddenly, however, I felt trapped. I was emailing for a way out. Above: This guy took me about an hour to beat. The feedback I got from Capcom confirmed my fears. They didn’t say it, but I will: Onimusha Way of the Sword is not for me. It’s a brutally hard game in need of a normal difficulty level. It’s a game that spikes so severely during its abundant boss fights—yet offers such flawed ways to improve when outside of them—that it feels like a bait-and-switch. In the new Onimusha, you play as famed samurai Musashi Miyamoto, aided by a magical soul-absorbing gauntlet that is possessed by a lady who offers advice. (Way of the Sword is a continuation of Capcom’s long-dormant Onimusha series, but that set-up had me wondering if the company was cribbing from their ill-fated Bionic Commando reboot; read about “wife-arm” when you get a chance). Way of the Sword is partially set in 17th century Kyoto, an explorable city where Miyamoto can fight demons, help civilians and eventually rescue ghostly dogs. The city evolves over time, with new mini adventures and obtainable loot on offer, all feeding into systems that promise to upgrade your gear and sword-fighting skills. Upgrades, however, are so incremental as to be imperceptible, causing the exploration of Kyoto to feel like inconsequential busywork. From that hub, players can go on linear missions into forests and old temples, where they will encounter many of the game’s tough bosses. Combat in Way of the Sword is akin to many modern melee games. Players are asked to mix attacks with dodges and parries. They’re encouraged to deplete an enemy’s stamina bar in order to do greater damage to its health bar. The old Onimusha games’ signature move was the issen, a counter-attack so sudden it’s all but pre-emptive. You strike just as they begin to strike toward you, beating them to the cut. By definition, the issen is a high risk move, leaving you wide open to pain. It feels risky in the game, especially against bosses, who can maul you in just a few blows. A game might train you to perform an issen well by offering a variety of lesser enemies who are not as tough as the boss but get close. Or it might offer a toehold against bosses by saving or checkpointing the player’s progress when a boss’ first health bar has been destroyed and before the second health bar appears. It might offer the less skilled player a chance to over-level their character, should the player simply commit to playing through its optional sidequests. Way of the Sword does none of this. Fighting its trivially easy grunt enemies and then its ferociously adept bosses is like playing a game of chess where I’ve got a rook, while the opposing side is all pawns and five queens. Bosses simply don’t checkpoint. You may be able to clear a boss’ first phase without taking much damage. Good for you. Do it again, every time you fail the second phase. As for the the central Kyoto hub, I kept pace with all of its added side activities and never felt like I was overpowered. Bosses could still easily buckle me. The new Onimusha, I concluded, is just too discouraging to keep playing. The advice I got from Capcom had been well-intentioned. They reminded me of the game’s various systems. They alerted me to an optional assist that flashes recommended button inputs (basically: counter this move; dodge that move). It was a little helpful. So was dropping down to “story mode,” which I tried last night. Story mode turns on those button prompts by default. It makes countering and dodging way too easy, nearly automatic. I don’t consider myself a master of action games like these, but I’ve cleared the likes of God of War, Stellar Blade, Star Wars Jedi and others of sub-Sekiro difficulty and had a fun time doing so. Not here. Not yet. Unless they patch Onimusha: Way of the Sword and add a middle difficulty or just checkpoint the damn bosses when they’re between health bars, my streak of loving Capcom games released in 2026 will likely end at two. It’s a shame, because I was having a good time finding those ghostly dogs. And then there’s He Who Watches, a phenomenal first person puzzle game with Portal vibes, except instead of a portal gun you’ve got a magical bow that shoots one arrow that can activate switches or be used to drag blocks. The twist is an actual twist: you can also walk on walls and the ceiling, reorienting gravity as you do, thereby placing blocks onto those other surfaces. Walking on walls and ceilings to solve problems is really the best thing. Would that I could in reality. He Who Watches consists of locked-room challenges, each brief enough to only require about a minute to actually solving, though it will take five, 10, eventually 30 minutes to figure out said solutions. They are not obvious! It’s a game of layered mechanics and shocking solutions. For example, see if you can follow this: You can drag a block to a wall. Then you can walk on the wall, which now feels like the floor, and drag that block across the wall. Later, back on the floor, you might realize you can look up. The block is still on the wall, stuck to it. You can shoot your magic arrow to its underside. Doing so creates a tether, so that you can yank the block off the wall and carry it, as if it were a balloon, into the spot where you need it to be to solve the puzzle. Here, watch Vanden explain some of the game’s basics in this launch trailer: As with any great puzzle game, the solutions to He Who Watches’ puzzles elicit relief and amazement. Oh my god, that worked! I didn’t even think that could be possible! Learning to solve the game’s puzzles feels like learning magic. But, oh, does the game get hard. Its Steam reviews, mostly glowing, are full of players remarking how quickly He Who Watches made them sweat. Wrote one: “loving this one already although my brain is hurting!” Wrote another: “As you get further in the game it feels like you need an IQ level of at least 120+.” Vanden has shown some mercy. Each locked room puzzle includes an optional junior version of the puzzle, meant to teach you. Difficulty nevertheless ramps severely. By the time I was emailing Vanden for help, I was struggling to even clear one of the hint puzzles. When I messaged him, my stress was exacerbated by strange things I’d found in the game’s various hubs: suspicious passageways, odd blocks and some intriguing locked doors. These were hints of secrets, I realized, yet I sensed I needed to play further into the game to understand them. I was stuck, but I wanted to see the rest. Vanden offered to give me the exact solutions, to solve those three puzzles for me, but first he gave four nudges. Three were for the specific puzzles, but his best hint was for all and ultimately proved to be a terrific life lesson: go back a bit, he suggested. Do the puzzles right before those. They were teaching you something. Focus on what their lesson was. Don’t rush, in other words. Recognize what you’ve accomplished. Build off of that. I did so. I absorbed the lessons. I saw those three tough puzzles in a new light. I solved one the night after he wrote back, another the morning after. I left a third for another time. I didn’t need it and I wanted to plunge deeper into the game, closer to the moment when I was sure I could start unlocking those secret doors. My head stopped hurting, too. He Who Watches feels special. It’s got more challenges, and I’m undeterred. It’s also nice that its puzzles don’t have a surprise second health bar. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: In brief… 🎮 Ilari Kuittinen, co-founder of Helsinki-based Housemarque (Super Stardust HD, Resogun, Returnal) has stepped down from his studio, after a 31-year run, saying he’s “ taking a rare and well-deserved breather.” Sony purchased Housemarque in 2021, and the studio released its newest game, Saros, earlier this year. Trend-watch: Sony-owned Insomniac saw its founder Ted Price retire in early 2025, after a 30-year run. Sony-owned Sucker Punch saw its co-founder Brian Fleming step down in late 2025, after a 28-year run. 👀 Savvy Games Group chief Brian Ward is stepping down from the Saudi-government-backed games conglomerate, Bloomberg reports. No word on a long-term successor yet, nor if this augurs any closer integration between Savvy and Electronic Arts. EA was purchased by a consortium led by Saudi’s sovereign wealth fund, in early August. 💿 Square Enix has denied a Japanese media report that the company was planning to go private. In very different Square Enix news, the company revealed that the physical version of Final Fantasy VII: Revelation, the April 2027 finale of its radical remakes of FFVII, will include just one disc in its case, requiring a download for the rest. The first two FFVII remakes in the trilogy shipped on two discs apiece. While Square hasn’t commented on the reason why, a feature here in Game File last month broke down the processes and costs for physical games. The expense of a second disc comes out of the game publisher’s cut of each copy. Square could be saving in excess of a dollar a copy with this move. 🟥 Grand Theft Auto IV’s 26-minute ’‘extended look” gameplay showcase that premiered on Netflix last week—and was exclusive to the platform for six hours—drew 31.1 million views in its first four days, the streamer announced. (Netflix calculates views as total viewed hours divided by runtime; excludes replays). Compared to YouTube: The version that later premiered on Rockstar Games’ YouTube channel is sitting at 22.6 million views after seven days (YouTube’s more liberal counting system tallies anyone who viewed even just the first few second.) Compared to other Netflix mega-events: Last year, Stranger Things season 5’s first four episodes, which debuted together, drew a record 59.6 million views in their first few days on Netflix. For more of a live event type of comparison, in 2024, the Jake Paul vs. Mike Tyson boxing match drew 65 million concurrent streams as it happened; Netflix didn’t release live numbers for the GTA premiere. ☁️ Microsoft is changing the way it charges for cloud gaming, from an all-you-can-play offer for Xbox Game Pass subscribers, to caps for the subscription’s tiers (15 hours per month at the Ultimate tier), with the option to buy more hours in bulk beyond that. The company also said it will sell batches of cloud gaming time to non-Game Pass subscribers, details TBA. Microsoft does not release figures for cloud game usage, but said its changes would impact 4% of Game Pass subscribers. That implies a small portion of its subscribers exceed the 15-hour monthly mark. Cloud gaming offers the promise of playing games without the need for console or PC hardware, as the graphics, sound and controls are all transmitted via a streaming connection. Microsoft notes that its cloud gaming service can be used for a range of things, including Xbox One players using it to play newer-gen Xbox Series games via streaming; and people playing games via streaming, sans any console, “in markets where consoles are less available or affordable.” (That latter use case could even be relevant in Xbox’s home market soon, as console prices keep rising.) Take Two Interactive chairman Strauss Zelnick recently told investors he expects game-streaming tech, which has been only lightly adopted by gamers for over a decade, to be widely used within three years. 🇺🇸 The Trump administration has published multiple agenda-driven web video games to the White House’s website. One called Build The Wall partially clones Tetris as it asks players to build a wall to stop a “zombie border siege.” While actual Tetris involves clearing lines and basically not building a wall, the Trump-backed game omits the line-clearing aspect (and omits the fun as well). On Instagram, Tetris’ official license holders reacted by stating: “At Tetris we believe in the power of connection and bringing people together, not dividing them. To our fans everywhere: we love you, we see you, and we’re grateful to have you in our community. P.S. The Tetris Company was not involved in the creation of ‘Build the Wall.’ P.P.S.: We take copyright infringement very seriously.” Item 3: The week ahead: Tuesday, September 8 Game releases: Mewgenics (consoles; already out on PC) is an engrossing tactical combat game (with cats). It is getting its console port right after the release of a Star Wars tactics game and ahead of the late September launch of a Fire Emblem–a bumper crop for the genre. Wanderburg (PC) is an auto-shooting game like Vampire Survivors, but you’re a castle on wheels Event: Nintendo airs a 30-minute Nintendo Direct (10am ET) focused on The Legend of Zelda’s 40th Anniversary. A full unveiling of the upcoming remake of The Legend of Zelda Ocarina of Time is expected. Will they also show footage from next year’s live action movie? Tease the next big 3D Zelda? Add Link to Mario Kart World? Shadow-drop a new Tingle game? Wednesday, September 9 Event: Nintendo again! On this day, they’re planning to air a 45-minute Nintendo Direct (10am ET) focused on games heading to Switch 2 this winter. Followed by about an hour of gameplay demoed by the company’s Treehouse team. The September Nintendo Directs are always some of the year’s biggest. The 2025 edition included announcements of several major 2026 Switch/Switch 2 games: Pokémon Pokopia, Mario Tennis Fever, Yoshi and the Mysterious Book, Fire Emblem Fortune’s Weave. Plus the return of the Virtual Boy. Friday, September 11 Game release: EA Sports NHL 27 (PlayStation, Xbox) is a hockey game. There are so few that an indie studio that had been making wacky sci-fi first-person shooters just announced that, hey, we’re going to fill a void and make a hockey game for PC.
Spot, snap and upload: Why California scientists want your nature photos
Use the iNaturalist app to track local species and help scientists protect California's unique natural heritage this Biodiversity week.
Pentagon agreement with NIH on biodefense draws alarm from Democrats
The deal is being criticized by Democrats who warn it could allow the Defense Department to go around Congress and gain access to billions of dollars meant for infectious disease research.
Scientists capture how bacteria build their protective antibiotic-resistant barriers
Gram-negative bacteria are responsible for causing several infections that are hard to treat, owing to their high resistance to antibiotics.
Pentagon Agreement With N.I.H. on Biodefense Draws Alarm From Democrats
Under a new partnership, the Defense Department would play a larger role in biodefense and pandemic preparedness. Democrats warned it could allow a Pentagon cash grab.
Baggies transfer window 'laser-focused'
Fan writer Chris Hall reflects on West Bromwich Albion's summer transfer window.
10 life sciences startups selected for accelerator program
Seven of the 10 companies participating in the fall cohorts of MassBio and SCbio’s Drive program are based in the United States, including four in Massachusetts.
Jaka Bijol: We have to be at our best
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Pick of the stats: West Bromwich Albion v Watford
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Research into muscular degeneration wins top prize at Birla Carbon Symposium
Kennesaw State University biology student Pedro Santos’ research project on muscular degeneration in fruit flies won the top prize at the 2026 Birla Carbon Scholars Symposium.
Information for supporters travelling to the Amex Stadium
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Scientists map key protein interactions linked with profound autism
Research published in the journal Science illuminates a "missing piece" in the biological understanding of profound autism and offers new targets for drug development.
Southcoast Health antibiotic stewardship program earns recognition
Southcoast Health earns a national designation for its efforts to ensure safe and effective antibiotic use.
English: College football politics are ravaging the game — for Texas, the show still goes on
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Ballot initiative would base Nebraska school sports participation on biological sex
Nebraska voters will decide in November whether state law should determine who can play on sports teams in the state.
Microbes—dead or alive—can be early indicators of soil health under regenerative farming
Researchers have demonstrated a series of biological tests that could serve as "proxies" for measuring how different regenerative agriculture practices could improve soil carbon—years before it would ...
NASA SMD ROSES-25 Amendment 68: New Opportunity: D.8 Habitable Worlds Observatory Precursor Science Investigations [UPDATE 2]
The Habitable Worlds Observatory (HWO)
Science Division launches five new centers to foster multidisciplinary research in areas of growing importance and interest
These centers debuted July 1 with five years of initial funding and will focus on marine genomics, geohazards, materials innovation, RNA science, and astrobiology.
Scientists revive coral dying from heat using live bacteria
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Seattle science powerhouses bet big on AI-designed biology
A new $95 million project could yield cancer treatments, genetic switches and plastic-eating enzymes.
People on the Move: Leo Russo, PhD, Joins Life Science Cares Philadelphia Board of Advisors
Life Science Cares Philadelphia has welcomed Leo Russo, PhD, to its Board of Advisors, bringing more than 25 years of pharmaceutical industry experience in…
HiFi sequencing sets the benchmark for environmental health metabarcoding
A new benchmarking study comparing PacBio, Illumina, and Oxford Nanopore finds that HiFi sequencing delivers the lowest error rate and highest taxa recovery for environmental metabarcoding. Here's what the results mean for biodiversity and environmental health research.
Billionaire family offices back health care and biotech startups in August
The personal investment firms of titans like Stanley Druckenmiller are backing innovations in gene editing, drug discovery and more.
Brain implants fuel U.S.-China bioscience rivalry
The devices are bringing new hope to patients with strokes, Parkinson's disease and other neurological conditions.
Biopharma needs more data scientists. Who's getting hired?
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Federal judge dismisses DOJ lawsuit challenging California policy allowing biological males in girls’ sports
A federal judge dismissed the Department of Justice lawsuit against California over transgender athletes competing in girls' sports on procedural grounds.
Rubio urges partners to stop 'business as usual' with Nicaraguan government
The U.S. urges international partners to immediately stop "business as usual" operations with Nicaragua's government, Secretary of State Marco Rubio said in a statement on Wednesday, adding that Washington remains committed to addressing violations of human rights by the government.
Rubio Urges Partners to Stop 'Business as Usual' With Nicaraguan Government
WASHINGTON, Sept 2 (Reuters) - The U.S. urges international partners to immediately stop "business as usual" operations with Nicaragua's government, Secretary of State Marco Rubio said in a statement on Wednesday, adding that Washington remains committed to addressing violations of ...
How a former ARPA-H director's startup is tackling AI's ‘dumb problems’
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“Broken heart syndrome” can look just like a heart attack. This test can tell them apart
“Broken heart syndrome” can mimic a heart attack so closely that patients often need invasive testing to tell the difference. Researchers have now developed the BioTAK score, which combines biological sex with blood biomarkers to identify the condition before cardiac catheterization. In a validation study of nearly 1,800 patients, it correctly classified almost 90% of participants.
Here's what to eat to protect your mouth's good bacteria
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Yamaha reacts to Quartararo complaint: 'He should follow Miller's example'
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SUNY Fredonia graduate takes FCS science job
Ava Waterman won’t have to travel far for her first teaching job. This fall, she makes the jump from SUNY Fredonia to the Fredonia Central School District as Fredonia’s new Science Teacher. Waterman graduated from SUNY Fredonia with a Bachelor’s Degree in Adolescence Education: Biology and is currently pursuing a Master’s Degree in Curriculum and […]
The Future of Lymphoma Care Is Moving Forward With Science | Targeted Oncology - Immunotherapy, Biomarkers, and Cancer Pathways
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Man City agree joint British record Enzo Fernandez move
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Transcat expands biomedical business with $12.8M acquisition
Transcat expands its biomedical calibration business with a $12.8 million acquisition of Southeastern Biomedical Associates in North Carolina, extending its reach in the Southeast.
Ada Yonath, Chemist and First Israeli Woman to Receive a Nobel, Dies at 87
Her mapping of the ribosome, which led to new designs for antibiotics, faced years of derision, as many scientists saw it as a dead-end effort.
LZ Sees Surprising Result in Search for Dark Matter
Key Takeaways Dark matter is the mysterious substance that accounts for the vast majority of matter in our universe. LUX-ZEPLIN (LZ) is a world-leading dark matter detector and specializes in searching for WIMPs, or weakly interacting massive particles. A new LZ study found one particle interaction that is difficult to explain with known background processes and could potentially have been caused by a WIMP. LZ continues to run to see if additional data strengthens or weakens the hint of a dark matter interaction. For the better part of a century, people have been trying to understand dark matter. This invisible substance makes up roughly 85% of the mass in the universe but has never been directly detected. Determining exactly what it is remains one of the biggest questions about our world. Now, a new analysis from the LUX-ZEPLIN (LZ) experiment has recorded a single particle interaction that researchers have great difficulty explaining with known background signals from normal matter. The result does not yet meet the statistical threshold required to claim a discovery, but is the most compelling hint of dark matter reported by the experiment to date. LZ is an international collaboration of 250 scientists and engineers from 39 institutions. The detector is managed by the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) and operates nearly one mile below ground at the Sanford Underground Research Facility (SURF) in South Dakota. The experiment uses 10 tonnes of ultrapure liquid xenon to search for dark matter and is optimized to look for WIMPs, or weakly interacting massive particles. The results were presented in a scientific talk at the 2026 TeV Particle Astrophysics conference in Japan. The paper will be released on the online repository arXiv and submitted to the journal Physical Review Letters. “We’re very intrigued to see this event in the data, in the region where we expect dark matter to show up and the competing backgrounds are very low,” said Rick Gaitskell, a professor at Brown University and the spokesperson for LZ. “With only one event, we don’t want to get ahead of ourselves. We are not claiming to have seen dark matter. But we have seen something interesting that we want to share with the scientific community for their input.” The LZ collaboration studies experimental data in batches. In the new result, researchers analyzed 220 live days of data collected between March 2023 and April 2024. The collaboration had previously searched this dataset for faint signals from the simplest kinds of WIMP interactions. The new analysis searched for a broader range of possible WIMP interactions that could deposit more energy in the detector. LZ is particularly sensitive to such signals while also minimizing false positives. “This was a detailed study in a region we hadn’t explored within this dataset, and we spent months of additional effort to understand all the possible causes of background events,” said Sam Eriksen, a senior research associate at the University of Bristol in the U.K. and lead author of the study. “We understand our detector and the backgrounds so well that even a single outstanding event, like the one we found, is important. We expect dark matter events to be extremely rare, so only a handful could mark the first detection of WIMP dark matter.” If the anomalous event was caused by dark matter, the WIMP that generated it would likely have a mass of at least 200 GeV/c2 (gigaelectronvolts), or more than 200 times the mass of a proton. It would also suggest a specific type of interaction between WIMPs and ordinary matter beyond the simplest model. The LZ results have not reached “5-sigma” significance, the statistical threshold considered a discovery in physics. The new analysis is 2.6 sigma, meaning there is approximately a 0.5% chance that the event could be explained by known backgrounds. With additional data, researchers can test whether the finding continues to grow in significance or fades away. LZ has already accumulated the world’s largest dark matter dataset and will continue to accrue WIMP search data at SURF, substantially improving their search statistics. LZ searches for dark matter by looking for signature flashes of light from energy deposited in the detector. The collaboration leverages multiple methods to prevent or account for particle interactions caused by normal matter. This includes the mile of rock that shields the detector from cosmic rays from space, a water tank and outer detectors that protect the central detector from background neutrons, and a suite of computational tools that disentangle particle interactions and reject dark matter mimics. “Outlier events in the data are not unexpected, but they usually stand out as a background of some kind when you look at them deeper,” said Aaron Manalaysay, a physicist at Berkeley Lab and the chair of LZ’s Institutional Board. “This is the first example in any experiment I’ve worked on of an outlier that appears valid in every way. Of course, we’re still twisting our brains trying to think if there’s a rare background mechanism we could’ve missed, but it’s thrilling to wonder if this could be the first hint of a dark-matter observation.” LZ is supported by the U.S. Department of Energy, Office of Science, Office of High Energy and Nuclear Physics, and the National Energy Research Scientific Computing Center, a DOE Office of Science user facility. LZ is also supported by the Science & Technology Facilities Council of the United Kingdom; the Portuguese Foundation for Science and Technology; the Swiss National Science Foundation; the Australian Research Council Centre of Excellence for Dark Matter Particle Physics; and the Institute for Basic Science, Korea. Thirty-nine institutions of higher education and advanced research provided support to LZ. The LZ collaboration acknowledges the assistance of the Sanford Underground Research Facility. ### Lawrence Berkeley National Laboratory (Berkeley Lab) is committed to groundbreaking research focused on discovery science and solutions for abundant and reliable energy supplies. The lab’s expertise spans materials, chemistry, physics, biology, earth and environmental science, mathematics, and computing. Researchers from around the world rely on the lab’s world-class scientific facilities for their own pioneering research. Founded in 1931 on the belief that the biggest problems are best addressed by teams, Berkeley Lab and its scientists have been recognized with 17 Nobel Prizes. Berkeley Lab is a multiprogram national laboratory managed by the University of California for the U.S. Department of Energy’s Office of Science. DOE’s Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit energy.gov/science.
Stop trying to maintain constant productivity: How you cope with stress changes with the seasons and your biological clock
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Bio-Techne Achieves Science Based Targets Validation and Reports Significant Progress Toward Climate Goals
/PRNewswire/ -- Bio-Techne Corporation (NASDAQ: TECH), a global provider of life science tools, reagents and diagnostic products, today announced significant...
What can seashells teach us about the health of our oceans?
Seashells: They're beautiful remnants to carry home from the beach—and so much more! According to environmental journalist Cynthia Barnett, seashells record history more accurately than the humans who first wrote it down. In this episode, we talk about the science of seashells, their impact on humankind and the scientist behind a very famous tongue twister.Check out Cynthia’s book The Sound of the Sea and check out Emily’s reporting on sandcastles.Interested in more marine biology stories? Email us your question at shortwave@npr.org.Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s hperks include sponsor-free listening. Learn more at plus.npr.org.
NSF launches three new Science and Technology Centers with $90M investment in transformative research
The U.S. National Science Foundation is investing $90 million over five years to support three new NSF Science and Technology Centers (NSF STC). These centers will advance American leadership in science and technology, strengthen the nation’s STEM workforce, and accelerate innovation in fields ranging from artificial intelligence and biotechnology to fusion energy and robotics., , , , The three centers will bring together researchers from universities, national laboratories, industry, and oth...
Half of women experience hair loss. Can this supplement actually help?
The brand behind URO Vaginal Probiotic is entering the hair wellness category with new supplement designed to help women experiencing hair thinning and shedding.
Run NVIDIA BioNeMo NIM Microservices for Protein Structure Prediction in Claude Science
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NASA Spaceline Current Awareness List #1,214 28 August 2026 (Space Life Science Research Results)
NASA Spaceline Current Awareness List
Biologists discover why snake embryos always coil to the right
A 'pillar of gut' is the key.
Justin Parent on unlocking the science of resilience in kids
Penn GSE associate professor Justin Parent investigates how childhood adversity becomes biologically embedded, with the goal of identifying opportunities to intervene early and help children thrive.
Why do some proteins accumulate even on protein-resistant surfaces?
Proteins with exposed arginine can selectively accumulate even on protein-resistant coatings, as reported by researchers from Science Tokyo. Through an in-depth analysis of which and how proteins adhere to various anti-fouling surfaces, the team found arginine disrupts the protective water layer that normally blocks adsorption. Their results will help scientists develop safer and more effective biocompatible materials for medical devices, such as stents and advanced biosensors.
Rice-developed BuoyBeads bring biotechnology lessons to high school classrooms
A biotechnology kit developed at Rice allows high school students to create living materials.
Popular sweeteners may leave effects that last for generations
Two widely used zero-calorie sweeteners, sucralose and stevia, may have effects that linger far longer than the sweet taste itself. In mice, researchers found that both sweeteners altered the gut microbiome, reduced beneficial compounds produced by gut bacteria, and changed the activity of genes involved in metabolism and inflammation. Some of those changes were also detected in later generations that had never consumed the sweeteners themselves.