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‘We need new blood’: Texas voters look for leadership changes, fresh faces this election year
Some vocal Texas voters say they want to get rid of politicians who've served the state for decades. Much of that sentiment can be boiled down to a preference for younger candidates with new energy — or even older ones who buck long-held status quo.
Woman With 3 Autoimmune Diseases Enters Remission After Immune 'Reset'
She no longer needs her daily blood transfusions.
Scientists just found a hidden “drain” inside the human brain
A hidden waste-removal pathway in the brain has finally been caught in action. Using cutting-edge MRI scans, researchers discovered that fluid flows along the middle meningeal artery in a slow, lymphatic-like pattern—very different from blood. This confirms the presence of a previously unknown drainage hub in humans. The finding could transform how scientists approach brain aging, injury, and diseases like Alzheimer’s.
I tested three Windows laptops in the MacBook Neo’s price range — there’s no contest
It’s a bloodbath.
Simple dinner table habit linked to poor diet and higher health risks in adults over 60
New research links the common habit of reaching for the saltshaker at dinner to troubling health patterns in older adults, including blood pressure and poor diet.
Why art is important for your health, just like exercise
Regular participation in the arts improves cognition, lowers blood pressure and reduces stress, according to "Art Cure: The Science of How the Arts Save Lives."
Brooke County Health Department eyes one Saturday a month for bloodwork appointments
Brooke County residents could soon have a new option for getting bloodwork done on weekends, as the Brooke County Health Department looks to expand its hours to
Galaxy Watch blood pressure monitoring isn’t approved by the US FDA
Samsung has confirmed that the Galaxy Watch blood pressure monitoring feature doesn't require approval from the FDA in the US.
10 RPGs that Turn into Different Games Halfway Through
From Star Wars: Knights of the Old Republic, Bloodborne and Final Fantasy VI: Here Are 10 RPGs that turn into different games halfway through.
Why are people turning to at-home blood testing? Meet SiPhox Health
SiPhox Health makes at‑home blood testing easy with up to 60 biomarkers starting at $99 — no needles, no lab visits, just clear health insights.
Diabetes rates are lower in high-altitude environments — and scientists may have discovered why
A new study finds that in low-oxygen environments, red blood cells absorb more glucose and convert it into a molecule that helps release oxygen into tissues, revealing an unexpected way the body regulates blood sugar.
Diabetes rates are lower in high-altitude environments — and scientists may have discovered why
A new study finds that in low-oxygen environments, red blood cells absorb more glucose and convert it into a molecule that helps release oxygen into tissues, revealing an unexpected way the body regulates blood sugar.
Scientists find hidden brain cells helping deadly cancer grow
Scientists in Canada have uncovered a surprising weakness in glioblastoma, one of the deadliest brain cancers. They found that certain brain cells—once believed to only support healthy nerves—can actually help tumors grow by sending signals that strengthen cancer cells. When researchers blocked this communication, tumor growth slowed dramatically in lab models.
Your ‘normal’ cholesterol and blood pressure may not be anymore
Americans should start guarding against heart disease earlier — and aim for lower cholesterol and blood pressure than ever before, according to new guidelines for heart health.
America’s Health Rankings puts Tennessee near bottom in blood pressure, cholesterol
America’s Health Rankings says...Tennessee ranks among the bottom ten states in several key health categroiesincluding 43rd in high blood pressure... and 45th i
Queens slashing suspects wanted for attacking man near sports bar in bloody assault
Detectives in Queens are looking for two men behind a violent, bloody slashing near a sports bar last month that left a man seriously wounded.
Young Adults With High Blood Pressure Face Higher Risk of Heart, Kidney Disease
Recent research suggests that adults ages 30 to 40 with high blood pressure may face a higher risk of cardiovascular and kidney disease later in life. These findings highlight the importance of maintaining a healthy blood pressure at a younger age.
Xbox's State Of Decay 3 Finally Returns, Signups Now Live For Alpha Playtests
"A mysterious broadcast calls to all survivors of the blood plague"
OMRON Healthcare and UCSF Launch AFib Trial
Study Will Explore Early Detection of Atrial Fibrillation to Reduce Stroke and Heart Failure Risk Through Home Blood Pressure Monitoring KYOTO, JAPAN - April 3, 2026 (NEWMEDIAWIRE) - OMRON Healthcare Co., Ltd. today announced the launch of a randomiz...
Innovative UC Health tool leads to better blood pressure control
‘These are real Californians who didn’t end up in an emergency room, didn’t have a disability, didn’t lose time with their families.’
NIH awards $15.8 million to University of California for study of Latino brain health
A multisite study led by UC San Diego and UC Davis will examine changes in brain imaging, blood biomarkers and cognition over time in Latino and Hispanic people.
He Studied How to Transport Blood to Wounded Marines
Peter Frazier’s lab at Cornell worked to improve how blood was stored and transported for armed forces. Then he received a stop-work order.
The Best Cocktail to Order on a Flight, According to Science
Wondering which is the best cocktail to order on a flight? A study shows the flavor of a Bloody Mary is enhanced by a plane's atmosphere.
Presidio landman Brett Barnes: 'This business is in my blood'
Brett Barnes is general counsel for Presidio Production, a Fort Worth upstream oil & gas company. But Barnes is a landman.
US Cardiologists Have Just Published New Guidelines For Managing Cholesterol
How to detect it and lower it.
Home-Delivered Groceries Boost Heart Health In Food Deserts, Study Says
By Dennis Thompson HealthDay ReporterWEDNESDAY, April 1, 2026 (HealthDay News) — Home-delivered groceries can help people who live in food deserts improve their heart health, a new study says. Black adults experienced a significant reduction in both blood pressure and cholesterol after receiving ...
SGMC Health Launches Prehospital Blood Transfusion Program, Advancing Trauma Care in South Georgia
SGMC Health has launched a prehospital blood transfusion program, marking a significant advancement in trauma care for South Georgia.
Samsung’s Blood Pressure Monitoring Feature Now Available to U.S. Users in Samsung Health
Select Galaxy Watch users in the U.S. can now measure and track blood pressure using Samsung Health
Samsung’s Blood Pressure Monitoring Feature Now Available to U.S. Users in Samsung Health
Select Galaxy Watch users in the U.S. can now measure and track blood pressure using Samsung Health
Galaxy Watch blood pressure monitoring reaches the USA after years of waiting
Samsung’s Galaxy Watch blood pressure monitoring feature is finally arriving in the US after years of waiting. Here’s all you need to know.
Samsung finally brings blood pressure tracking to US Galaxy Watches
Six years after it launched in South Korea, and you still need a traditional blood pressure cuff to calibrate it once a month.
‘Blue Bloods’ Actor & Comedian Alex Duong Dies at 42
He also appeared in 'Everybody Hates Chris,' 'The Young and the Restless,' and more.
Scientists solve 40-year-old biological mystery behind sleeping sickness
To survive in the human bloodstream, the African trypanosome parasite wears a "cloak" made of proteins known as a variant surface glycoprotein (VSG). The study, published in Nature Microbiology, identifies ...
New cholesterol guidelines could change when you get tested
A major new U.S. cholesterol guideline is shifting the focus toward earlier, more personalized prevention of heart disease. It urges people to start screening sooner—sometimes even in childhood—and highlights the importance of tracking not just LDL (“bad”) cholesterol but also genetic risk factors like lipoprotein(a). A new, more advanced risk calculator now uses broader health data to better predict heart attack and stroke risk over decades.
Popular sugar substitute linked to brain damage and stroke risk
A widely used sugar substitute found in everything from keto snacks to diet drinks may not be as harmless as it seems. New research shows that erythritol can disrupt brain blood vessel cells, reducing their ability to relax, increasing harmful oxidative stress, and impairing the body’s ability to break down clots. These changes create conditions that could raise stroke risk, even at typical consumption levels.
Scientists discover a hidden system that turns brown fat into a calorie burner
Scientists have identified a key biological system that helps brown fat burn energy by building the networks it needs to function. A protein called SLIT3 splits into two parts, with each piece guiding the growth of blood vessels and nerves inside brown fat. These structures allow the tissue to pull in nutrients and rapidly convert them into heat instead of storing them as fat.
Why Wild Blueberries Are Getting Attention for Heart and Metabolic Health Benefits
Wild blueberries may support heart health by improving blood vessel function, lowering blood pressure, and aiding cholesterol and blood sugar control.
North Carolina coaching search: Billy Donovan, Tommy Lloyd and other top candidates address UNC job
The blue blood opening in Chapel Hill has created serious buzz in the college basketball coaching world
The Fake Cartier and the Fake Rockefeller
How a pair of blue-blood impostors turned party crashing in the Hamptons and Palm Beach into a business.
Will Blue Bloods Continue to Dominate Mach Madness in the NIL Era?
College basketball has changed because of NIL. The Big Ten has risen, old-school coaches have adapted, and the talent pool is deeper than ever.
Exclusive: Prenuvo expands full-body MRI protocol. What's new?
Prenuvo is launching a new bloodwork component to complement its full-body MRIs. Here's what to know.
Winners and losers from first weekend of the NCAA tournament feature John Calipari, Darryn Peterson, Big Ten and blue bloods
A DNA test ruled him out. He was convicted of murder anyway.
Forensics has its share of high-profile problems. There’s phony “junk science,” like bogus bite-mark and blood spatter analyses that have sent innocent people to jail. And there’s the steady drumbeat of lab scandals, where analysts make up results. But there’s a subtler and more pervasive problem at work in many cases: lab analysts and lawyers who take perfectly legitimate science and twist it. Globe Opinion is exploring these distortions with a series we’re calling “Twisted Science.” And there may be no better place to start than with the case of Terrel Barros.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Scientists discover surprising brain trigger behind high blood pressure
Scientists have uncovered a surprising brain-based trigger for high blood pressure, tracing it to a small region in the brainstem that normally controls breathing. This area, which kicks in during forceful exhalations like coughing, laughing, or exercise, also appears to activate nerves that tighten blood vessels—raising blood pressure. When researchers switched off this region in experiments, blood pressure dropped back to normal, suggesting it plays a direct role in hypertension.
Bloodstained: The Scarlet Engagement listed for Nintendo Switch, plus an unannounced 505 Games Switch 2 title
Bloodstained: The Scarlet Engagement has been listed for Nintendo Switch alongside an unannounced Switch 2 title from 505 Games. The Scarlet Engagement, a sequel to the original, was previously announced last year. Although there wasn’t any news about a Nintendo release, the latest discovery suggests that we’ll be getting it on Switch at the very least. It’d be somewhat surprising...
UFC London’s Felipe Franco promises entertainment after teammate Jailton Almeida’s release: ‘They want to see blood’
Felipe Franco battles undefeated Mario Pinto at UFC London
6 Supplements That May Support Heart Health
Supplements that may support heart health include garlic, fiber, and red yeast rice. They may lower cholesterol levels and improve blood pressure.
Brain’s protective barrier stays leaky for years after playing contact sports
Damage to the blood-brain barrier is linked to immune changes and cognitive decline
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Molecule in python blood could pave way for new obesity drugs, scientists say
Researchers find snake metabolite that suppresses appetite of obese mice ‘without some of side-effects’ of GLP-1 drugs
UC-created algorithm can help treat chronic health condition
High blood pressure affects about half of U.S. adults.
This 2019 Bloody Horror Hit Is A Top Movie On Hulu Right Now
See what else is trending on streaming services this week.
Southeast Asian Fuel Prices Destabilize Politics
Indonesia, for one, has a bloody history of fuel-related riots.
Country music star bloodied onstage and fans are livid: ‘He needs to press charges’
Fans are angry that the star was injured during his show.
Fetuses likely have more ‘forever chemicals’ in blood than thought
US test of 120 umbilical blood cord samples identified 42 Pfas compounds, which do not naturally break down
‘How Low Can You Go?’ The Shifting Guidelines for Blood Pressure Control
The number doctors use to demarcate hypertension keeps going down, a trend applauded by many experts, who point to studies linking high blood pressure and dementia.
NBC Abruptly Axes Decades-Old Shows in Cancelation Bloodbath
“Access Hollywood” is the oldest show to bite the dust in NBC’s retooling.
NBC Abruptly Axes Decades-Old Shows in Cancelation Bloodbath
Access Hollywood’s 30-year run is coming to an end. The flagship entertainment news program NBC created in 1996 to compete with CBS’s Entertainment Tonight will stop producing new episodes in Septembe...
New cholesterol guidelines released by the American Heart Association
Also, for the first time, doctors are advised to test for two biomarkers in the blood that have been linked to increased risks of heart disease.
Depression may start with an energy problem in brain cells
Researchers have discovered a surprising change in how cells produce energy in people with depression. Brain and blood cells in young adults with major depressive disorder produced more energy molecules at rest but had trouble increasing energy production when needed. Scientists believe this imbalance may contribute to symptoms such as fatigue and low motivation. The finding could help pave the way for earlier diagnosis and more personalized treatments.
Two People Die at Paid Plasma Donation Clinics in Canada
Grifols, a Spanish health care company, operates clinics in Canada that collect blood plasma from donors in exchange for an honorarium.
PlayStation Plus Extra February games for March leak
It seems that PlayStation's upcoming PS Plus Extra games for March have leaked.
Regeneron Science Talent Search 2026 Recognizes America’s Top Young Scientists, Awarding More Than $1.8 Million to High School Seniors for Innovative Research in Computational Mathematics, Neural Science, and Blood Cancer Treatment
$250,000 top award goes to Connor Hill in America’s longest running and most distinguished science and math competition Top $250,000 Regeneron Science Talent Search Winner Named Regeneron and Society for Science announced that Connor Hill, 17, of State College, Pennsylvania, won the top award of $250,000 in the 2026 Regeneron Science Talent Search (STS), a program of Society for Science. TARRYTOWN, N.Y. and WASHINGTON, March 10, 2026 (GLOBE NEWSWIRE) -- Regeneron Pharmaceuticals, Inc. and Societ
Stress of Pregnancy Complications Might Impact Future Heart Health, Study Says
By Dennis Thompson HealthDay ReporterTUESDAY, March 10, 2026 (HealthDay News) — Women who have pregnancy complications might face a higher risk of heart disease, a new study has concluded. The stress of these complications increase a woman’s risk of high blood pressure for years after they deliver,
EQT Foundation opens applications for science grants to overcome the blood-brain barrier and transform CNS drug delivery
EQT Foundation is launching a new open call for proposals under its Science Grants program, focused on breakthrough innovations to cross or modulate the blood-brain barrier (BBB) for therapeutic delivery to the central nervous system. The program will award catalytic, non-dilutive grants of €25,000 to €100,000 to researchers developing high-risk, high-impact deeptech solutions with the potential to unlock a new era of Central Nervous System (CNS) medicine. Designed to accelerate bold scientific
Scientists found a surprising way to make exercise work better
Exercise normally boosts the body’s ability to use oxygen, a key marker of health and longevity — but high blood sugar can block that benefit. Researchers found that a ketogenic diet helped mice normalize blood sugar and dramatically improved how their muscles responded to exercise. Their muscles became better at using oxygen and built more endurance fibers. The results suggest diet and exercise may work together in surprising ways to improve metabolic health.
'It's a very unique biological specimen': The scientists using menstrual blood to diagnose diseases
From diagnosing endometriosis and cervical cancer to diabetes, vitamin D deficiency, and pollution exposure, here's what menstrual blood can reveal about your health.
What intermittent fasting really does for your body and brain
Fasting has been shown to reduce blood pressure, improve cognition, and even reverse chronic disease. But experts say the benefits may not apply to everyone.
Tehran residents donate blood amid ongoing US-Israel attacks on Iran
Scientists say this simple diet change could transform your gut health
A growing trend called “fibermaxxing” is putting dietary fiber in the spotlight—and for good reason. Fiber plays a powerful role in keeping the body healthy, from supporting digestion and feeding beneficial gut microbes to helping regulate blood sugar and cholesterol. Researchers say getting enough fiber may even lower the risk of conditions like obesity, diabetes, and certain cancers.
Scientists say this simple diet change could transform your gut health
A growing trend called “fibermaxxing” is putting dietary fiber in the spotlight—and for good reason. Fiber plays a powerful role in keeping the body healthy, from supporting digestion and feeding beneficial gut microbes to helping regulate blood sugar and cholesterol. Researchers say getting enough fiber may even lower the risk of conditions like obesity, diabetes, and certain cancers.
Scientists discover protein that triggers diabetic blindness
A newly identified protein may hold the key to preventing diabetic blindness. Researchers discovered that LRG1 triggers the earliest damage in diabetic retinopathy by constricting tiny retinal blood vessels and reducing oxygen supply. In mice, shutting down this protein stopped the damage before it could take hold. The finding could pave the way for treatments that protect vision before symptoms ever begin.
The Business of Babies’ Gut Health, Planned Parenthood’s Botox Push and What to Know About Multi-Cancer Blood Tests | WSJ Health for March 6
Plus, why Planned Parenthood is making a Botox push and what to know about multi-cancer blood tests
Health Care Has Become the Lifeblood of the Labor Market
An aging population is drawing workers to medical and social care, creating reliable jobs and revealing weakness for the rest of the economy.
Antarctica Looks Like It’s Bleeding. Scientists Finally Figured Out Why.
The Blood Falls is the result of a complicated interaction in which overlying ice, underlying rock, and an ancient lake bed form a pretty unsettling natural display.
5 Questions: For Erik Langendal, small businesses are the rising tide that lifts all boats
Erik Langendal hadn’t exactly planned on going into the family business, Anders Langendal Boatbuilder & Sons, in the Clarke Shipyard at the end of East Front and Carpenter streets in Greenport. But a life lived on and ruled by the water was in his hardy half Swedish blood — and impossible to refuse. He knows...
Guardant Health Launches Coast-to-Coast Screening Tour, Bringing Shield Colon Cancer Blood Test to Over 100 Communities Across America
Shield Across America mobile screening tour launches during Colorectal Cancer Awareness Month to address nation’s dangerously low screening rates by bringing Shield blood test directly to Americans Route will focus on rural communities across the country with the lowest screening rates and highest CRC incidence and mortality Shield is proven to increase screening rates with a 93% adherence Guardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, today announced the launch of Shield Across America, a historic coast-to-coast mobile screening tour bringing Shield, the first and only FDA-approved blood test as a primary colorectal cancer (CRC) screening option and recommended in national guidelines , directly to over 100 communities across the country from Las Vegas to Hartford, Atlanta and more. Mobile screening bus providing Shield by Guardant Health, the first and only FDA-approved blood test for primary colorectal cancer screening From national sporting events to
'Blood moon' total lunar eclipse dazzles millions around the world (photos)
Here are the first images of the March 3 'blood moon' total lunar eclipse visible over North America, Australia, and eastern Asia.
Common Arthritis Drug Found To Lower Blood Pressure and Boost Heart Health
A widely used treatment for rheumatoid arthritis may offer an unexpected cardiovascular benefit. Methotrexate has been a staple treatment for rheumatoid arthritis for decades, valued for its ability to calm an overactive immune system and reduce painful joint inflammation. Now, researchers say it m
Following This 3-Hour Rule Before Bed Could Support Healthy Blood Pressure and Blood Sugar
New research links not eating for a few hours before bed—and 13 to 16 hours overnight—with better heart health and blood sugar markers.
Actor and Cancer Advocate Patrick Dempsey Partners with Guardant Health to Raise Awareness about Colorectal Cancer Screening and Shield Blood Test, Sharing His Experience Getting Screened
1 in 3 eligible Americans avoid colorectal cancer (CRC) screenings because traditional methods are viewed as unpleasant and inconvenient Guardant's FDA-approved Shield blood test offers an easier, more convenient way to screen with a blood draw from any prescribing healthcare provider for adults 45+ at average risk for CRC Motivated by his mother’s cancer fight, Dempsey is calling on Americans to prioritize getting screened this CRC Awareness Month Guardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, today announced its partnership with actor and cancer advocate Patrick Dempsey to increase awareness about colorectal cancer (CRC) screening and the Shield® blood test. Approved by the U.S. Food and Drug Administration (FDA) in 2024 and recommended in national guidelines , Shield offers an easier way to screen for colorectal cancer (CRC) with just a blood draw for eligible individuals 45 and over at average risk for the disease. Patrick Dempsey, actor and cancer
What’s Up: March 2026 Skywatching Tips from NASA
What are some skywatching highlights in March 2026? A total lunar eclipse blood moon takes centre stage, Venus and Saturn cozy up for a conjunction, and we celebrate the vernal equinox.
John Kimmel Steps Away from Training to Focus on Bloodstock Business
John Kimmel has announced his retirement from training on the New York circuit to focus on building his bloodstock buisness.
Turnover in East Texas politics may jeopardize regional sway at the Legislature
Some advocates for the region worry freshmen lawmakers will start deal-making at a deficit, while other voters see a chance for new blood.
Rare ‘blood moon’ total lunar eclipse to loom over North America, Australia and New Zealand
Eclipse will feature a deep, coppery-red full moon on 3 March, with scientists predicting the best times to see it
What Happens to Your Blood Pressure and Cholesterol When You Eat Eggs Every Day
Eggs are high in cholesterol, and some studies raise concerns about them for people with high blood pressure. But research shows most people can eat them as part of a heart-healthy diet.
Chris Bosh: 'Covered in my own blood' during health scare
Hall of Famer Chris Bosh revealed he's happy to be alive after a recent health scare left him covered in his own blood.
Former Miami Heat star Chris Bosh 'lucky to be alive' following health episode
"So I woke up covered in my own blood," said the 41-year-old basketball Hall of Fame member.
Chris Bosh says he's 'lucky to be alive' after health scare
Chris Bosh said that he's "lucky to be alive" after a recent health scare that resulted in him waking up "covered in my own blood."
The more you fear aging, the faster your body may age
Worrying about getting older—especially fearing future health problems—may actually speed up aging at the cellular level, according to new research from NYU. In a study of more than 700 women, those who felt more anxious about aging showed signs of faster biological aging in their blood, measured using cutting-edge “epigenetic clocks.” Fears about declining health had the strongest link, while concerns about beauty or fertility didn’t appear to have the same biological impact.
New Duke Health study finds simple blood test could predict longer life
Duke Health researchers found small RNA molecules known as piRNAs can accurately predict whether older adults are likely to survive at least two more years.
Michigan Voices: Seeking understanding after Trump's SOTU|Opinion
During the State of the Union Address, bad blood boiled over. Trump called Democrats “crazy.” Rep. Rashida Tlaib, D-Michigan, wore a \
What Taking Short Stretch Breaks During the Day May Do for Your Blood Sugar and Joint Health
Stretching throughout the day could support blood sugar regulation and joint health. Here's what to know.
Why heart disease and stroke are expected to rise significantly among younger women
Obesity, diabetes and high blood pressure are fueling increases in cardiovascular disease, even among much younger women, the American Heart Association said.
Sofia Vergara on How Her Mom Inspired Her Heart Health Mission
Sofia Vergara joins TODAY to talk about “America’s Got Talent” as it begins its 21st season, appearing in three Super Bowl commercials during one game, and how her mom’s experience with high blood pressure inspired her heart health mission to spread awareness about uACR tests that detect early kidney damage. (Sponsored by Boehringer Ingelheim)
Octavia Spencer Talks New Film 'Tow,' Prioritizing Her Health, More
Actor Octavia Spencer joins TODAY to talk about her new movie, “Tow,” with a star-studded cast, including Rose Byrne, Ariana DeBose and more. She also reflects on 14 years since winning an Oscar for her role in “The Help.” Then, she discusses living with type 2 diabetes and high blood pressure and how she's raising awareness about the related risks and the importance of testing for early signs of kidney damage. (Sponsored by Boehringer Ingelheim)
Trump's Ukraine peace deal stalled as bloody war hits 4-year mark
Experts say Vladimir Putin has peruaded U.S. negotiators that he wants to cut a deal – even as Moscow rains missiles and drones on Ukrainian cities.
Simple blood test can forecast Alzheimer’s years before memory loss
Scientists have created a blood test that can estimate when Alzheimer’s symptoms are likely to begin. By measuring a protein called p-tau217, the model predicts symptom onset within roughly three to four years. The protein mirrors the silent buildup of amyloid and tau in the brain long before memory loss appears. This advance could speed up preventive drug trials and eventually guide personalized care.