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Business Lookahead: Gauging the war's impact

STORY: From a worrying drop in stocks to a surge in energy prices from the war in the Middle East to key data on jobs and trade, these are the stories to watch in business and finance in the coming week. ::Look Ahead::War impactThe first quarter is ending with financial markets at the mercy of geopolitics.The Iran war has wiped roughly $7 trillion off global stocks since it erupted.With oil prices up nearly 70% year to date, suddenly interest rates are heading up, rather than down, and energy-hungry AI does not look like such a slam-dunk anymore.Meanwhile, gold has plunged 16% after being nearly unstoppable since the start of 2025.We’ll see whether markets roll on or rollover as the second quarter begins.::Job growth in focusThe U.S. jobs report for March comes out Friday.It will offer a crucial view into the economy's health as investors gauge fallout from the energy price surge.Monthly payrolls are seen rising by 48,000, according to a Reuters poll. February's surprisingly weak report caught Wall Street off guard, showing nonfarm payrolls fell by 92,000 while the unemployment rate increased to 4.4%.Uncertainty over the Iran war is also clouding the economic forecasts for the Federal Reserve, with Wall Street pulling back on expectations for U.S. interest rate cuts this year as the oil price surge fuels concerns about rising inflation.Other U.S. data in the coming week includes retail sales for February and reports on manufacturing and services activity.::Chip checkSouth Korea releases its trade data for March on Wednesday.It will provide an early indicator of how the global economy is holding up in the face of the war and the resulting shock to energy prices. Korea's export-heavy economy is a bellwether for global trade and one of the first to report data from the previous month.Its manufacturing fortunes are of even greater interest than usual, not just because of its dependence on Middle Eastern energy imports, but also because its world-leading DRAM chips are of critical importance to the AI sector and currently in short supply too. ::Inflation assessmentAnd flash euro zone inflation for March is due on Tuesday. After long hovering around the 2% mark, higher energy prices are now expected to push headline inflation up, as they did in 2022. The question is, how large and sustained any jump in inflation might be.Early data is not painting a pretty picture. Private sector growth in the euro zone slowed sharply in March, with input costs rising to their highest in more than three years and supply chains being significantly disrupted.Money markets are now heavily pricing in a rate hike which was almost unthinkable before the Iran war.

Mar 27 • 3:28 PM EDT • Business • finance.yahoo.com

Apple Discontinues Mac Pro Desktop in Favor of the Mac Studio

Apple Inc. on Thursday discontinued the Mac Pro desktop, its highest-end computer aimed at video editors, photographers and other advanced users.

Mar 26 • 5:23 PM EDT • Technology • bloomberg.com

Top End Sports brings sports-based wheelchairs to life

Inside a Pinellas Park warehouse, precision engineering meets purpose. Top End builds equipment that helps athletes around the world compete at the highest level.

Mar 26 • 3:22 PM EDT • Sports • fox13news.com

Record-high passenger wait times at airports, but no deal yet on the 40th day of the shutdown

The acting head of the Transportation Security Administration says air travelers are experiencing the highest airport wait times ever under her agency.

Mar 25 • 4:58 PM EDT • Politics • pbs.org

Glyphosate: A story of science, risk, and nuance

In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe

Mar 25 • 10:25 AM EDT • Science • yourlocalepidemiologist.substack.com

Entertainment Poll: Who is the highest paid (annually), active athlete on the planet?

Test your knowledge!

Mar 24 • 8:00 PM EDT • Entertainment • 9and10news.com

UAB scholar receives highest recognition from national small-business and entrepreneurship association

UAB scholar receives highest recognition from national small-business and entrepreneurship association

Mar 24 • 8:00 AM EDT • Business • uab.edu

When Religion Becomes Obsolete, Politics Tries to Save Us

When politics becomes our highest love, it will also become our cruelest disappointment, leaving our homes colder, our holidays lonelier, and our common life harder to sustain.

Mar 23 • 8:00 PM EDT • Politics • thepublicdiscourse.com

Segment: Financing Action on Extreme Heat and Maternal and Newborn Health: The Way Forward

The segment “Financing Action on Extreme Heat and Maternal and Newborn Health: The Way Forward” will examine how innovative and better-aligned financing approaches can respond to these growing risks. Discussions will highlight country experiences in mobilizing domestic resources, opportunities to unlock and scale climate finance, and the role of heat-smart innovations in building resilient health systems. Particular attention will be given to low- and middle-income countries, where exposure and vulnerability remain highest, and where integrated solutions can deliver the greatest impact.

Mar 23 • 8:00 PM EDT • Health • pmnch.who.int

Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com

Acuff scores 36 as Arkansas holds off No. 12 seed High Point 94-88

Two of the highest-scoring teams in the nation combined on a back-and-forth affair that featured 15 lead changes and six ties.

Mar 22 • 8:28 AM EDT • Sports • spectrumlocalnews.com

Chuck Norris's Second Highest-Rated Movie Is One He Spent About 30 Seconds In

The second highest-rated movie associated with Chuck Norris is one he didn't even have a starring role in.

Mar 21 • 10:16 PM EDT • Entertainment • mensjournal.com

Top 5 states with the highest number of safest hospitals, according to new report

Healthgrades named 438 hospitals across 40 states for its 2026 Patient Safety Excellence Award, with Texas and Florida among the top-performing states.

Mar 21 • 4:25 PM EDT • Health • foxnews.com

Exclusive: Amazon plans smartphone comeback more than a decade after Fire Phone flop

In 2014, Amazon introduced its first smartphone, hoping to take on Apple and Samsung. Instead, the Fire Phone - overseen directly by founder Jeff Bezos - was scrapped in barely over a year, one of Amazon’s highest-profile flops.

Mar 20 • 6:01 AM EDT • Technology • reuters.com

Mortgage rates jump to highest level in nearly 4 months

The average rate on a 30-year fixed mortgage rose this week to 6.22%, according to the latest Freddie Mac data released Thursday. That is up from last week's reading of 6.11%.

Mar 19 • 12:24 PM EDT • Business • foxbusiness.com

Girls in Math and Science Day welcomes young scientists with unique STEM experiences

The Mid-Michigan Graduate Women in Science chapter and campus RSO hosted a Girls in Math and Science Day on March 14. This year’s event had the highest attendance since the pandemic, with an estimated 150 kids, 150 volunteers and 80 parents in attendance.

Mar 16 • 8:00 AM EDT • Science • statenews.com

School IB business management class: European alternatives to Visa and Mastercard ‘urgently’ needed, says banking chief

Operations management

Mar 15 • 11:29 PM EDT • Business • ft.com

Business school professors’ picks

Topical FT articles and suggested classroom questions

Mar 15 • 11:21 PM EDT • Business • ft.com

Oil prices climb past $105 a barrel as war in Iran enters third week

The price of oil rose to its highest level since July 2022 Sunday evening as the Trump administration suggested the war with Iran could last several more weeks and President Donald Trump called on the international community for help reopening the Strait of Hormuz to oil tankers.

Mar 15 • 6:38 PM EDT • Business • cnn.com

Louisiana had the 7th highest percentage of children with oral health problems. See U.S. data.

In 2024, about 15% of children in the U.S. ages 1 to 17 reported oral health problems, according to data analysis from the Kaiser Family Foundation.

Mar 15 • 6:00 AM EDT • Health • nola.com

How much Uber, Lyft, DoorDash, other gig workers made per hour in 2025

Taskrabbit, Walmart's Spark, and Uber were among the gig-work services with the highest hourly rates in 2025, new data from Gridwise found.

Mar 15 • 5:52 AM EDT • Business • businessinsider.com

Why people believe conspiracy theories: A political scientist’s view

Political scientist Joseph Uscinski, a professor at the University of Miami, talks about conspiracy theories and the people who believe them. Uscinski’s research has found that conspiracy theories are not new, nor are they more prevalent than in the past. What has changed, he says, is that people at the highest echelons of power in the United States are embracing conspiracy theories, and conspiracy-mindedness is becoming more concentrated in one political party than in the past.

Mar 12 • 6:00 AM EDT • Politics • thebulletin.org

Ohio State's Matt Patricia is college football's highest-paid assistant: Buckeyes reward DC after Year 1

Four assistants, including the Buckeyes' defensive coordinator, are set to make at least $3 million next season

Mar 11 • 3:05 PM EDT • Sports • cbssports.com

Health department: ‘Steep rise’ in uninsured Minnesotans

Rising costs and fewer people on public health insurance programs contributed to the highest rate of uninsured Minnesotans since 2017.

Mar 11 • 6:39 AM EDT • Health • minnpost.com

We're aiming for a 100% growth rate of the AI server business in 2026: Asus co-CEO

S.Y. Hsu, co-CEO of Asus, says it's "highly possible" that enterprise and commercial products will be the highest revenue grossing segment of the company, and that they are aiming to begin mass production of Nvidia Vera Rubin servers in 2026. He also expects the current shortage of memory chips to last until Q4 of 2027.

Mar 11 • 3:55 AM EDT • Business • cnbc.com

Microsoft SQL Server Zero-Day Vulnerability Allows Attackers to Escalate Privileges

Microsoft has disclosed a critical zero-day vulnerability in SQL Server that allows authenticated attackers to escalate their privileges to the highest administrative level on affected database systems.

Mar 10 • 11:14 PM EDT • Technology • cybersecuritynews.com

Bam Adebayo erupts for 83 points in Heat's win over Wizards, passes Kobe Bryant for second-highest scoring game history

Bam Adebayo had a career-high 43 points in the first half alone on Tuesday night at the Kesaya Center.

Mar 10 • 10:11 PM EDT • Sports • sports.yahoo.com

Uninsured rate in Minnesota spikes, climbing to the highest level in 6 years

Uninsurance rates have risen across the state and among nearly all demographic groups, highlighting persistent disparities, the health department said.

Mar 10 • 5:06 PM EDT • Health • mprnews.org

NextDecade Corporation (NEXT) Provides Fiscal Q4 2025 Business Update

NextDecade Corporation (NASDAQ:NEXT) is one of the best oil stocks with highest upside potential. NextDecade Corporation (NASDAQ:NEXT) provided an update on the developmental and strategic activities for fiscal Q4 2025 and early fiscal Q1 2025 on March 2. The company reported that it commercialized and attained positive final investment decisions (FIDs) on Trains 4 and […]

Mar 9 • 3:29 AM EDT • Business • finance.yahoo.com

VIEW Oil surges 20% as Iran war fuels supply fears

Oil prices jumped about 20% in early trading on Monday, ​hitting their highest since July ‌2022, as the expanding U.S.-Israeli war with Iran fuelled fears of tighter supply ​and prolonged disruptions to ​shipments through the Strait of Hormuz.

Mar 8 • 8:35 PM EDT • Business • reuters.com

Iran Has a New Supreme Leader. What Does That Mean?

Mojtaba Khamenei takes on a role that makes him not only Iran’s spiritual leader but also the highest authority in the land.

Mar 8 • 5:56 PM EDT • Politics • nytimes.com

WBD Sports Announces Historic First for Downhill as Elite Women Will Race Last at the Leogang World Cup

"This change marks a powerful shift in visibility, recognition and parity for women’s racing at the highest level."

Mar 8 • 8:53 AM EDT • Sports • pinkbike.com

Donkey Kong Bananza's Emerald Rush is one of Nintendo's best and most underrated DLCs

W look at Donkey Kong Bananza's Emerald Rush mode, one of Nintendo's most underrated (and highest-value) DLC packages in recent times.

Mar 8 • 12:50 AM EST • Technology • nintendoeverything.com

iPhone 17e Benchmarks Reveal A19 Chip Performance With a Tiny Catch

The first benchmarks for the iPhone 17e surfaced in the Geekbench 6 database today, offering a closer look at the A19 chip's performance. For multi-core CPU performance, the highest score the iPhone 17e achieved so far is 9,241. As expected, this is nearly identical to the standard iPhone 17 model with the A19 chip, which has an average multi-core score of 9,249. There is one tiny catch, as the iPhone 17e has a 4-core GPU, whereas the iPhone 17 has a 5-core GPU.

Mar 6 • 4:18 PM EST • Technology • macrumors.com

15 Foods Highest in Vitamin B12 for Energy and Brain Health

Foods like crab, trout, salmon, and clams are high in vitamin B12. These and other B12-rich foods can offer health benefits.

Mar 6 • 7:00 AM EST • Health • health.com

Apple no longer offers M3 Ultra Mac Studio with original highest RAM configuration

A year ago today, Apple unveiled the M4 Max and M3 Ultra Mac Studio desktop computer. In addition to Thunderbolt...

Mar 5 • 3:12 PM EST • Technology • 9to5mac.com

Louisiana has the highest incidence of prostate cancer in the nation. See the parish data.

Prostate cancer is the most common cancer in American men, with an estimated 333,830 new cases and 36,320 deaths projected for 2026 for the disease, according to the American Cancer

Mar 5 • 12:00 PM EST • Health • nola.com

In Sierra Leone, a New Maternal Hospital Aims to be the Blueprint

The country has one of the highest maternal mortality rates in the world. Isata Dumbuya, a nurse and midwife, has made it her mission to change that.

Mar 4 • 5:06 PM EST • Health • nytimes.com

Guardant Health Launches Coast-to-Coast Screening Tour, Bringing Shield Colon Cancer Blood Test to Over 100 Communities Across America

Shield Across America mobile screening tour launches during Colorectal Cancer Awareness Month to address nation’s dangerously low screening rates by bringing Shield blood test directly to Americans Route will focus on rural communities across the country with the lowest screening rates and highest CRC incidence and mortality Shield is proven to increase screening rates with a 93% adherence Guardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, today announced the launch of Shield Across America, a historic coast-to-coast mobile screening tour bringing Shield, the first and only FDA-approved blood test as a primary colorectal cancer (CRC) screening option and recommended in national guidelines , directly to over 100 communities across the country from Las Vegas to Hartford, Atlanta and more. Mobile screening bus providing Shield by Guardant Health, the first and only FDA-approved blood test for primary colorectal cancer screening From national sporting events to

Mar 4 • 7:00 AM EST • Health • investors.guardanthealth.com

Pokopia Joins A 3DS Entry As The Highest-Rated Pokémon Game On Metacritic

It's super-duper effective

Mar 4 • 5:00 AM EST • Technology • nintendolife.com

Two senior Communist Party officials absent at top Chinese political event

Two senior Chinese officials were absent on ​Wednesday from the ranks of ‌China's highest tier of power at the opening of the country's ​two largest political events ​of the year, with top ⁠Communist Party cadres ensnared ​in a wave of purges.

Mar 4 • 2:19 AM EST • Politics • reuters.com

Pokopia Becomes Highest-Rated Pokémon Game On Metacritic

Pokémon Pokopia has surpassed Pokémon Y to become the most highly recommended Pokémon game ever, according to the aggregator

Mar 2 • 11:30 AM EST • Technology • kotaku.com

US manufacturing grows steadily in February, input prices surge

U.S. manufacturing activity expanded steadily in February, but a measure of prices paid by factories for inputs rose to the highest level in nearly 3-1/2 years, highlighting upside risks to inflation amid import tariffs even before ​a U.S.-led attack on Iran sent oil prices higher.

Mar 2 • 10:04 AM EST • Business • reuters.com

Musk points to highest 'ever' usage of X amid US-Israel strikes on Iran

Elon Musk says the X platform saw its highest usage ever following US-Israeli airstrikes on Iran that killed Supreme Leader Khamenei and top officials.

Mar 1 • 7:54 AM EST • Business • foxbusiness.com

Colorado’s Olympic medalists, the Nuggets’ season so far, and more sports news

KGNU’s Aramis Loma Guzman sat down with host Abby O’Brien to discuss Colorado’s Olympians, the Nuggets’ rocky season, and local soccer and football news. Colorado sent 32 athletes to the Winter Olympics — the highest number of any state. Nine gold medals were brought home by notable athletes like ...

Feb 25 • 1:49 PM EST • Sports • kgnu.org

Morehead State alum inducted into Sports Broadcasting Hall of Fame

A Morehead State University alum who went on to soar in sports broadcasting has received one of the field's highest honors. Marc Herklotz (Class of 1981) was inducted into the Sports Broadcasting Hall of Fame in December 2025. Herklotz worked on the technical side of broadcasting for over 30 years and had a special interest in sports broadcasting. Under ESPN's umbrella of sporting events, Herklotz worked directly with Sunday Night Baseball and Football, Monday Night Football and Home Run Derbies. For more information about Herklotz's career and the Sports Broadcasting Hall of Fame, visit their website. To learn more about the Department of Communication, Media, Art & Design programs, please email cmad@moreheadstate.edu or call 606-783-2766.

Feb 25 • 12:10 PM EST • Sports • moreheadstate.edu

Why Bills' highest priority has to be Josh Allen-centric

This is really a no-brainer.

Feb 22 • 5:57 PM EST • Sports • sports.yahoo.com

Dan Marino ranked as 10th best quarterback of all time

Marino is highest ranked quarterback to have never won a Super Bowl.

Feb 21 • 11:54 AM EST • Sports • sports.yahoo.com

Bears' best players in 2025 season, per Pro Football Focus

Here's a look at the highest-graded players for the Chicago Bears on offense and defense from the 2025 season.

Feb 21 • 11:42 AM EST • Sports • sports.yahoo.com

Meet the officials tasked with delivering Mayor O’Connor’s vision for growth in Pittsburgh

One central campaign promise defined new Mayor Corey O’Connor’s bid for Pittsburgh’s highest office: growth across the city. Time and...

Feb 21 • 4:00 AM EST • Business • post-gazette.com

FDA Announces Peanut Butter Recall in 40 States—Products May Contain Pieces of Plastic

The FDA has given the recall the second-highest risk level, as consuming foreign materials poses a safety hazard.

Feb 17 • 7:00 AM EST • Health • health.com

Warmer Valentine’s Day boosts small business sales

The average person in the U.S. is expected to spend a record $200 on Valentine’s Day this year, the highest in 25 years.

Feb 14 • 5:30 PM EST • Business • spectrumnews1.com

Ranked: The Best Countries at Science

See which countries rank highest in science literacy, based on the latest OECD PISA scores of students aged 15 to 16 worldwide.

Feb 14 • 9:49 AM EST • Science • visualcapitalist.com

PFF: 5 highest-graded Bills players on defense in 2025

Here's who the five best Bills players were on defense during the 2025 NFL season, according to Pro Football Focus.

Feb 14 • 9:45 AM EST • Sports • billswire.usatoday.com

Hedge funds bet big against Hims & Hers Health before Wegovy showdown, Hazeltree data shows

Hedge fund bets against Hims & Hers Health hit their highest in at least a year in January, just before the online telehealth firm clashed with Novo Nordisk over its cut-price weight-loss pill, according to data shared with Reuters by Hazeltree.

Feb 13 • 8:22 AM EST • Health • reuters.com

Engineered safflower harvest boosts GLA yields 57% in U.S.

1,100 acres of GLASO1 safflower yielded ~2,200 lbs/acre, a 57% gain, validating Moolec's ~45% GLA concentration at commercial-scale U.S. crushing.

Feb 13 • 8:00 AM EST • Science • stocktitan.net

The 13 college majors with the highest unemployment rates

The 13 college majors with the highest unemployment had rates above 6%. College graduates looking for work can network and broaden their job search.

Feb 12 • 4:53 AM EST • Business • businessinsider.com

Why the UC system is seeing a drop in computer science enrollment

It was once a degree to some of the highest-paying jobs in the world, but now the University of California is seeing a drop in enrollment for computer science.

Feb 10 • 7:55 PM EST • Science • nbcbayarea.com

Classic rock legends are coming to Hershey for a concert

The group is one of the highest-charting bands in Billboard history, with Top 40 albums in six consecutive decades.

Feb 9 • 10:59 AM EST • Entertainment • pennlive.com

Forests are changing fast and scientists are deeply concerned

Forests around the world are quietly transforming, and not for the better. A massive global analysis of more than 31,000 tree species reveals that forests are becoming more uniform, increasingly dominated by fast-growing “sprinter” trees, while slow-growing, long-lived species are disappearing. These slower species act as the backbone of forest ecosystems, storing carbon, stabilizing environments, and supporting rich webs of life—especially in tropical regions where biodiversity is highest.

Feb 8 • 7:00 PM EST • Science • sciencedaily.com

'Overwatch' just hit its highest player base on Steam PC since launch — passing Battlefield 6 and Call of Duty

All it needed was a flying kitty. Overwatch is so back, as the kids say.

Feb 8 • 10:20 AM EST • Technology • windowscentral.com

The sports with the highest injury rates at the Winter Olympics

With all eyes on the 2026 Milan Cortina Winter Olympics, athletes are gearing up to deliver jaw-dropping moments of speed, skill and courage.

Feb 6 • 10:54 AM EST • Sports • click2houston.com

January layoffs rose to the highest level for the month since 2009

Major employers including UPS and Amazon announced significant job cuts in January, with transportation and tech sectors leading the nationwide layoffs surge.

Feb 5 • 12:07 PM EST • Business • foxbusiness.com

Patriots Legend Shockingly Snubbed From Controversial Super Bowl Rankings

Pro Football Focus, aka PFF, kicked off Super Bowl week by releasing a list of its eight highest-graded quarterback performances in the Super Bowl since 2006. Shockingly, Tom Brady was nowhere to be found. Brady played in seven Super Bowls over the last 20 years, winning four. He had multiple iconic performances during that time, […]

Feb 3 • 8:16 AM EST • Sports • sports.yahoo.com

Radiology among the 5 highest paid professions, US News & World Report says

Members of the specialty earned a median salary of approximately $239,200 last year, based on survey data gathered by the media company last fall.

Feb 3 • 4:20 AM EST • Business • radiologybusiness.com

Survey finds prior authorization viewed as greatest hurdle in navigating health care

A KFF survey published today found that people view prior authorization as the biggest challenge beyond costs when navigating the health care system. In terms of issues people viewed as a “major burden,” prior authorization was highest at 32%, followed by understanding their bill or what they owe at 23%.

Feb 2 • 10:24 AM EST • Health • aha.org

5 ChatGPT Prompts To Identify Your Highest-Leverage Activities In Business

Busy but not profitable? These 5 ChatGPT prompts reveal your highest-value activities so you can stop guessing and start growing.

Feb 2 • 10:00 AM EST • Business • forbes.com

UK Chiefs’ Confidence Jumps in Latest Sign of Economic Momentum

UK business confidence leaped to its highest in eight months, adding to evidence that the economy may be gaining momentum after the budget.

Feb 2 • 2:00 AM EST • Business • bloomberg.com

Companies reporting earnings are doing just fine, despite tariffs

Companies in the S&P 500 may be on track to report the highest net profit margins in at least 15 years, suggesting tariffs aren't harming industry.

Feb 1 • 2:24 PM EST • Business • usatoday.com

New PS5 Exclusive Is the Highest-Rated Game of 2026

A new PS5 console exclusive game is the 2nd highest-rated of 2026, according to review scores on Metacritic.

Feb 1 • 11:54 AM EST • Technology • comicbook.com

'New evidence' gives Jordan Chiles a chance to secure the return of her Olympic bronze medal

Switzerland's highest court has sent the case of Jordan Chiles' disputed bronze medal from the 2024 Paris Olympics back to the CAS based on 'new evidence' that might prove favorable for the U.S. gymnast.

Jan 29 • 3:15 PM EST • Sports • latimes.com

International Business Machines Corp (IBM) Q4 2025 Earnings Call Highlights: Record Revenue ...

IBM reports its highest revenue growth in years, driven by software and infrastructure performance, while setting ambitious goals for AI and hybrid cloud advancements.

Jan 29 • 12:01 AM EST • Business • finance.yahoo.com

Republicans Gave ICE a Slush Fund. Democrats Want to Limit It.

The sweeping domestic policy law that Republicans muscled through Congress last year made ICE the highest-funded federal law enforcement agency in the country, with no strings attached.

Jan 28 • 3:43 PM EST • Politics • nytimes.com

Who was Ajit Pawar, the Indian politician killed in plane crash?

Pawar was a key political figure and served as second-highest elected official in Maharashtra, India's wealthiest state.

Jan 28 • 6:25 AM EST • Politics • aljazeera.com

Investing in high performance sports

Germany’s athletes have received increasing funding and support since the Olympic Games Munich 1972, support that has translated into greater success at the highest level.

Jan 28 • 4:50 AM EST • Sports • olympics.com

US business borrowing for equipment rises over 5% in December, ELFA says

U.S. companies borrowed 5.9% more to finance equipment purchases in December than a year earlier, reaching the second-highest level ever, the Equipment Leasing and Finance Association said on Monday.

Jan 26 • 3:10 PM EST • Business • reuters.com

TikTok sets up US unit under Trump deal but leaves core business with ByteDance

Video app launches US joint venture with American investors to enact deal criticised by China hawks

Jan 22 • 8:31 PM EST • Business • ft.com

Trinity Rodman signs 3-year deal with Washington Spirit, becomes highest-paid women's soccer player in the world

Jan 22 • 6:28 PM EST • Sports • sports.yahoo.com

Texas' reported $2.2 billion valuation leads nation as college football business skyrockets

The Wall Street Journal has released its study on highest valuations within college football

Jan 19 • 10:35 AM EST • Sports • cbssports.com

Best and worst PFF grades from the Panthers' 2025 season

Which Panthers finished with the highest (and lowest) PFF grades from their 2025 season?

Jan 18 • 4:30 PM EST • Sports • pantherswire.usatoday.com