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New Day Cleveland: Crafty World Entertainment
Cleveland's source for news, weather, Browns, Guardians, and Cavs
Walmart and Sam’s Club combine plus memberships into one fee
Walmart and Sam’s Club are combining memberships into one fee of $120 annually or $10 per month beginning Oct. 20. This is the first time the two business segments have...
Georgia: Secretary General Alain Berset calls for safeguarding democracy and political pluralism ahead of opposition ban hearings
Council of Europe to closely follow developments and continue dialogue with Georgia
EXCLUSIVE: SANTOS BRAVOS to return to NYC for one-night-only event at The Paley Museum
SANTOS BRAVOS will appear at The Paley Museum on Nov. 4 for a live music and storytelling event, amNewYork has exclusively learned.
TENNESSEE VOLS BASKETBALL: Eight VFLs on NBA rosters
Eight players who concluded their college careers at the University of Tennessee are on opening day NBA rosters, as released by teams across the league Monday night.
Johnson’s winning coalition fractures as two SEIU locals back Giannoulias
Mayor Brandon Johnson had all three SEIU locals in 2023, but they broke from his coalition after he took office
New comet accidentally discovered by space telescope
The ‘happy coincidence’ is currently more than 807 million miles from Earth.
Opinion: A Bears stadium deal must deliver more than a home for football
Keeping the Bears in Chicago could create opportunities for local businesses, but a stadium deal must also deliver measurable economic returns and inclusion.
New Stockton-ACIT Partnership Creates Buzz About Bees
Levine, Gormley Foundations support drone work to study blueberry pollination
Moment of Science: New electric current test measures coffee quality without tasting
Getting a clue about the perfect brew! Here's how new research could make sure your morning pick-me-up is "not your average Joe". ☕
Starbucks Just Ruled Out Buying Chipotle. Small-Business Owners Should Take Notice
Starbucks’ turnaround offers small business owners a powerful lesson: communicate your value to customers before changing your price.
Macron jets out of riot-torn France for Gulf trip as political pressure mounts
French President Emmanuel Macron left for Kuwait energy talks as riots raged, drawing sharp criticism from Marine Le Pen and Jean-Luc Mélenchon.
You Should Probably Check Your Google Home Speaker’s Data Usage
Google Home Speakers have been absolutely ripping through data—mine included.
NFL Mexico and CONADE Join Miami Dolphins Academy to Create Year-Round Flag Football and Education Programming Across the Country
The initiative, implemented through the Global Markets Program (GMP), reflects the commitment of the Miami Dolphins and their local partners in Mexico to promoting sports and bringing physical education to communities across the country.
Feeling overstimulated in public? Mental health experts share the strategies that work in any situation
Sensory overload can hit in a grocery store, on a commute or at a crowded party. Here's what therapists and a Harvard psychiatrist recommend, including a few products worth keeping in your bag.
Walmart has a new bundle for Plus and Sam's Club
Walmart is offering a new membership bundle that combines Walmart Plus and Sam's Club Plus for less than the price of a Costco Executive membership.
Evolution of women’s healthcare focus of URI’s annual Youngken Clinic
KINGSTON, R.I. — Oct. 20, 2026 — Women’s healthcare is evolving rapidly, and while greater emphasis has been placed on comprehensive care, women still face more barriers to healthcare than men, according to the National Institutes of Health. Pharmacists are key players in helping break down those barriers, playing an increasingly important role in improving […]
Amazon plans more than 2,000 holiday hires in Tampa Bay
The online retailer’s nationwide hiring target includes roughly 21,000 employees from Florida, with more than 300,000 nationwide.
Berkshire Hathaway Specialty launches in Poland
U.S.-based Berkshire Hathaway Specialty Insurance Company has entered the Polish market, Coverager reported. The company offers a wide range of commercial insurance across Central and Eastern Europe…
11 PS Plus Extra Game Removals for November 2026 Confirmed
Rockstar drops PS Plus support again
HCA Healthcare honors Portsmouth Regional Hospital volunteer...
Portsmouth Regional Hospital volunteer Brendan O’Brien received HCA Healthcare’s 2026 Frist Humanitarian Award after contributing more than 1,500 hours supporti...
Morning 3: Lincoln County home health worker accused of taking thousands in forged checks -- and other news
Here are the top stories for the morning of Oct. 20, 2026
tvOS 27.2 adds three new features to your Apple TV 4K
tvOS 27.2 is coming next week, bringing several new features—including screen saver upgrades—to Apple TV 4K users. Here’s what’s new.
Nine State Board of Education seats are on the ballot this fall, including 4 in the Greater Houston Area
The state board of education is one of the most influential bodies shaping education across the state. The board sets curriculum and chooses instructional materials for all public school classrooms and in recent years has been scrutinized for its controversial choices.
Home health worker accused of taking thousands in forged checks in Lincoln County
The employee allegedly took checks from a checkbook while providing care at a patient’s house.
Meta (META): Can WhatsApp Become a Meaningful Business Beyond Advertising?
Meta Platforms, Inc. (NASDAQ:META) is turning business conversations into revenue. Paid WhatsApp messaging helped Family of Apps other revenue grow 73% to $1.01 billion in the second quarter of 2026, following 74% growth in the first. That category includes subscriptions and other services and represented just 1.7% of group revenue. Expanding messaging alternatives make merchant […]
Romanian lawmakers back government led by independent Luca Niculescu as country seeks to end monthslong political crisis
Romanian lawmakers back government led by independent Luca Niculescu as country seeks to end monthslong political crisis.
On Chatham Business Tour, Mayor Talks Recent Burglary Sprees: 'More Work To Be Done'
Mayor Brandon Johnson’s neighborhood tour came on the heels of a string of break-ins on 75th Street and didn’t include visits to the businesses that were burglarized.
Trumbull Health Department Holding Walk-in Flu Clinics This Week
The Trumbull Health Department will be having walk-in flu clinics this week:TODAY, 10/20/27: 10-12pm and 2-4pmWednesday, 10/21/26: 6-8pm 335 White Plains Road No appointment required!We will
Bush family royalty backs Democrat in battle to flip Texas blue
Barbara Bush donated $2,500 to a PAC supporting James Talarico's Texas Senate race against Ken Paxton, using her real name in public FEC filings.
HOMETOWN HEALTH: Researchers identify new clues for treating type 2 diabetes
The study's authors say this could be developed into new treatments that could help people regulate their blood sugar.
UW-River Falls to offer Halloween carnival and 'Haunted Lab' science demonstrations Oct. 20
Two special Halloween-themed events are planned at the University of Wisconsin-River Falls on Tuesday, Oct. 20, including a Halloween carnival and “Haunted Labs” science demonstrations.
T-shirts and silver balls: Politics get mixed in with the profane at a Trump store
By Elle Reeve, Samantha Guff, Frank Fenimore, CNN Boones Mill, Virginia (CNN) — Walk into Trump Town USA in Boones Mill, Virginia, and you may marvel at the breadth of human creativity, as long as you’re not distracted by how the merchandise tackles some of the most controversial political issues in the most vulgar way
Gentle Brain Ultrasound May Help Ease Delusions in Schizophrenia
NYU Langone pilot study shows that transcranial ultrasound stimulation may safely treat delusions in schizophrenia and schizoaffective disorder. Learn more.
In-Person Briefing: Fixing the No Surprises Act
The event will feature real-life perspectives from businesses/employers and physicians on navigating the IDR process and resulting outcomes.
SRS names former Allianz exec to alternative risk role
Strategic Risk Solutions said Tuesday it has appointed former Allianz Commercial executive Chris Terry as managing director and head of alternative risk transfer and risk strategy, effective April 19…
What enjoying the journey has taught me: Olivia Arnold
CSU Assistant Professor Olivia Arnold discusses the value of being open to new experiences and her passion for teaching undergraduates.
Law & Order: College Basketball — How the NCAA's eligibility rules have created chaos before the season's even begun
As the college basketball season quickly approaches, many schools are still trying to fill out their rosters as they navigate legal challenges to NCAA eligibility rules.
'Office Space' star Richard Riehle dies at 78
Actor Richard Riehle arrives at the premiere of New Line Cinema's 'A Very Harold & Kumar 3D Christmas' at Grauman's Chinese Theatre on November 2, 2011 in Hollywood, California. (Jason Merritt/Getty Images)Richard Riehle, known for his role in the 1999 film Office Space, has died. He was 78.A statement shared by Artists & Representatives and Wright Entertainment, Inc. announced Riehle's passing on Monday, writing, "Our industry has lost an exceptional talent, and our community has lost a truly wonderful man.""We are deeply saddened to confirm the passing of our beloved client, Richard Riehle, this past weekend," the statement said. "A remarkable actor whose career in theater, film, and television spanned nearly five decades and more than 400 projects, Richard leaves behind an extraordinary legacy."The statement continued, "Beyond his immense talent, he will be remembered for his genuine goodness, boundless kindness, and unwavering generosity, particularly toward emerging actors and filmmakers, whom he encouraged and supported at every opportunity."Born on May 12, 1948, Riehle starred in many television series and films over the years.Notable projects include Casino, The Man from Earth and Deuce Bigalow: Male Gigolo.He got his start as an actor at the University of Notre Dame, where he was involved in the University Theatre and starred in several stage productions. He went on to earn a Master of Fine Arts in acting and directing from the University of Minnesota.While he's played characters that have an "average Joe" presence, he always made the most of his brief screen time.Some roles that he is remembered for include The Quartermaster in Glory, the train guard in The Fugitive, Reverend Scroggins in Fried Green Tomatoes and Bill Cozbi in Bridesmaids.On television, he starred as Principal Ed Rooney in the 1990 series Ferris Bueller and as grandfather Walt Finnerty in the early 2000s sitcom, Grounded For Life.In 2023, he also played Warden Reynolds in Barry.Riehle is survived by his wife, Jane Latham, and their four children.Copyright © 2026, ABC Audio. All rights reserved.
Romania Politics Government
Romanian Prime Minister designate Luca Niculescu attends a joint parliament session called to give a vote of confidence for the new government team, in Bucharest, Romania, Tuesday, Oct. 20, 2026.
JMU Military Science program prepares future military leaders
JMU’s Army ROTC program combines rigorous training, hands-on leadership development, and strong alumni support to prepare cadets for success as future military officers.
Revisiting Brewers' Adames Trade Which Included Rays' Rasmussen
The Milwaukee Brewers transformed their infield with a midseason swap, but the Tampa Bay Rays struck gold by turning a struggling reliever into a dominant ace.
Romania Politics Government
Romanian Prime Minister designate Luca Niculescu, left, talks to the Interior Minister designate, Marian Neacsu during a joint parliament session called to give a vote of confidence for the new
Spanish Science Fiction Horror Film MEMORIA to Get Release from Mondo Macabro
Memoria 1 Blu-ray disc Label: Mondo Macabro Preorder: 11/10/26 Release: 12/8/26 MSRP: $29.99 UPC: 843276036195 Catalogue #: MDO361 Genre: Horror Color 87 minutes in Spanish with English subtitles MPAA Rating: NR High Definition 1080p 1.66:1 Dolby Digital
New Book Includes Previously Unreleased Interviews By Edward Gorey
For ardent Edward Gorey fans there’s a new book available, “Memento Gorey: The Last Interviews with Edward Gorey” by Chatham filmmaker and documentarian Christopher Seufert, published by Schiffer Publishing with
Could AI Use a Simple Photo of Your Face to Reveal Clues About Your Health?
A new AI model can estimate biological age and predict cancer survival outcomes using a simple photo of a patient’s face, though more research is needed before doctors will be able to use it to help them decide on treatments.
Are partisan politics even changing up our accents? They just might be, y’all
Vowels have become the latest players in partisan politics, a barometer of how beliefs and values fit within the old vs. new South.
12 rising actors you didn’t know have famous parents
Having famous parents doesn’t necessarily get you the role — but it does get you in the room. Read about 12 nepo babies on the rise, including who their parents are and where you recognize them from.
KFF Tracking Poll on Health Information and Trust: Fall 2026 Update on Vaccine Views
The latest KFF Tracking Poll on Health Information and Trust finds about half of parents mistakenly believe spacing out vaccines is healthier for children, while confidence in many long-standing childhood vaccines is high across partisans. These findings take on new relevance following President Trump's recent executive order calling for changes in U.S. childhood vaccine recommendations, including splitting the measles, mumps, and rubella (MMR) vaccine—currently given as a single combined shot—into three separate vaccines across multiple visits.
3+ useful features included with Google One that people ignore
Google One plans started off as a way to expand storage limits for files and photos, but they now include AI features, family sharing and YouTube packages.
‘These risks are real’: the threat of AI bioweapons
In his annual speech on threats to the nation, Sir Ken McCallum, the head of the UK’s intelligence service, MI5, warned that AI had the potential to ‘change the stakes’ on existing and even new bioweapons. To find out why, and how, Ian Sample speaks to Dr Tom Inglesby, director of the Johns Hopkins Center for Health Security and the Bloomberg School of Public Health. He explains what has governments so worried and what measures could be put in place to reduce the risks
Dejan Kulusevski shares heartbreaking admission after making ‘impossible’ injury comeback
Surgery on his right patella in May last year was followed by multiple setbacks
AI is Changing Science: Here’s What Journalists Need to Know
Researchers are rapidly adopting AI for everything from data analysis to planning and executing entire research studies. Journalists will need to keep up. That means learning the basic principles, strengths, and weaknesses of the diverse technologies labeled as “AI”—and how to tell when using AI in science is actually noteworthy. Luckily for science reporters, knowing your beat well can help you cut through the hype.
Spotify launches paid podcast memberships with perks beyond bonus content
Spotify's new paid memberships let podcasters offer fans exclusive perks, including ad-free listening, early access, and bonus content, while keeping 90% of the revenue.
Astronomers uncover new secrets of the Universe’s first five minutes
Scientists have achieved a major breakthrough in understanding the Universe’s earliest moments, measuring the amount of helium formed in the first five minutes after the Big Bang with unprecedented precision. Using one of the world’s most powerful telescopes, an international team studied 15 remarkably pristine galaxies that act as cosmic time capsules, preserving clues from nearly 13.8 billion years ago.
The Science Communication Challenge in Cosmetics
The Cosmetic, Toiletry and Perfumery Association held its inaugural scientific conference and discussed the importance of clear, concise communication in cosmetics.
Tecsys delivers AI capabilities to help health systems anticipate and act on pharmacy and supply chain risks
/PRNewswire/ -- Tecsys Inc. (TSX: TCS), an industry-leading supply chain management company, today announced the availability of AI solutions that help health...
How much is DeForest Buckner worth on the trade market?
DeForest Buckner is still one of the Colts’ best defensive players, but age and his contract complicate his trade value.
Sponsored Content: HMG Health Matters: A Surgeon's Perspective on Breast Cancer
Dr. Cheryl Stanski, General Surgeon and Vice President of Holston Medical Group tells us what she wants every woman to know about breast cancer. She talks about the success rate, the hope, and the options now available for women. For more information and to read more please visit the Health Matters blog at HolstonMedicalGroup.com.
Romania Politics Government
Romanian Prime Minister designate Luca Niculescu arrives for a joint parliament session called to give a vote of confidence for the new government team, in Bucharest, Romania, Tuesday, Oct. 20,
Cristiano Ronaldo ‘let Man Utd down’ with lack of effort
Cristiano Ronaldo “didn’t prepare himself” properly during his second stint at Man Utd and the club was “not the highest priority” for him, according to Erik ten Hag. The former Red Devils b...
Tennessee health departments providing free flu vaccines Tuesday
TRI-CITIES, Tenn. (WJHL) — Health departments across the Northeast Tennessee region are offering free influenza vaccines on Tuesday as part of a statewide annual “Fight Flu” prevention …
NBA live streams: How to watch basketball games without cable in 2026-27 season
Here's how to watch NBA basketball without cable, including the best streaming options for each game of the 2026-27 season.
Foldables are about to get huge
iPhone Duo demand meets a long delivery queue, giving Samsung's Galaxy Z Fold 8 an opening. Plus the latest Google and Android news.
Ambetter Health Announces 2027 Marketplace Offerings, Including Enhanced Condition-Specific Coverage Options
/PRNewswire/ -- Ambetter Health, the Health Insurance Marketplace product of Centene Corporation (NYSE: CNC), today announced its 2027 Marketplace offerings,...
Inc. Names Counterpart a 2026 Power Partner for Supporting Small Businesses
Counterpart, the AI-native insurance platform providing management and professional liability solutions to small businesses, has been named a 2026 Inc. Power...
Revolut and other banking apps go down as Google Cloud suffers outage
Google Cloud is experiencing service disruptions in London, along with multiple banking apps including Revolut.
A note to readers: Science, accountability and elections
Dear readers, As early voting begins, I wanted to share some news — and why it connects to the decisions we make at the ballot box. I’ve been selected for the inaugural cohort of the South Atlantic Climate Journalism Hub mentorship program, hosted by Covering Climate Now. I’m excited to join this group, learn from scientists and fellow journalists, and expand my science reporting. Science directly ties to governance. Local officials make decisions about where development goes, how infrastructure is maintained, what emergency preparations receive funding, and how communities rebuild after disasters. Understanding the evidence behind those decisions helps us evaluate whether our government is serving us well. Here in western North Carolina, those connections are all around us, in Lake Lure and beyond. Flood maps inform decisions about property and development. Engineering assessments help identify risks at dams and bridges. Rainfall forecasts guide emergency preparations. Geological information helps explain landslide hazards. Water testing gives communities information they need to assess conditions. Meteorologists’ knowledge and public perception of weather events shape public safety. Each involves scientific or technical knowledge. Each also raises questions about public responsibility: What did officials know? How did they use that information? What did they tell the public? What did taxpayers receive for their money? A study can identify a problem. Elected officials still have to decide what to do about it, how to pay for it, and how to explain their choices. Reporting should examine both the evidence and the response. That is where I want to strengthen my work. My reporting on Helene recovery, infrastructure, flooding, public safety, and public spending has repeatedly brought me to questions that require scientific expertise alongside public records. This mentorship may help me better understand the research, ask more precise questions, and explain the answers clearly. I also bring the perspective of someone living with these concerns. I live downstream of Lake Lure Dam, and landslides affected my property during Helene. Those experiences bring urgency to my questions. Careful reporting helps establish the answers. Readers deserve to know what the evidence shows, where uncertainty remains, and whether officials accurately describe the information guiding their decisions. You also deserve scrutiny of proposed solutions: what they cost, what they are expected to accomplish, and what risks remain. Access to that information matters. As a mostly deaf journalist who relies on written communication, I will continue pressing for written public warnings, records, and explanations that people can read and use in real time. As you consider the candidates seeking your vote, consider how they approach evidence, preparedness, and transparency. Do they support local journalism, even when it’s not parroting a press release? Do they explain weather events clearly in plain English and explain their decisions after them? Make supporting records available? Acknowledge uncertainty? Follow through when a report identifies a risk? Those are practical questions about governing. Thank you for supporting Cops & Congress and the work that makes these questions part of the public conversation. I’m grateful to David Dickson and the CC Now team for this opportunity, and I look forward to bringing what I learn back to you. Annie DanceEditor & Publisher, Cops & Congress — Learn more about this newsletter, ethics policy, how you can help shape this work, and support it. Follow on X and Facebook. Send constructive criticism, fan mail, and tips with public documents for future stories: CopsandCongress@gmail.com ICYMI: View the Cops & Congress archive — Annie Dance is the publisher of Cops & Congress, a newsletter that analyzes what happens when crime, courts, disaster, democracy, and small-town policies collide. Views expressed here are covered by the First Amendment. Dance has a Bachelor of Arts from Manhattan University in Communication with a focus in Journalism and Government. She has been a journalist for over 20 years. Share Upgrade now or give a gift subscription
Bill Nye "The Science Guy" makes surprise appearance in Rutherford County
Nashville News, Weather, and Sports
China’s Ultimate Political Survivor Just Fell. What That Says About Xi’s Rule.
Plus, export-driven growth rebounds, masking deepening economic problems that are creating a lost generation.
The Case for Republicans to Hold the Senate | WSJ Politics Newsletter for Oct. 20
Plus, seven candidates tell The Journal how they would fix Congress, and an Abdul El-Sayed opponent handed him a viral campaign highlight.
Mahjong studio opens in Blue Springs as the centuries-old Chinese game sees a surge in new players
A new Blue Springs studio, Bam Bird Social, is dedicated to teaching and playing mahjong as the game surges in popularity.
Miniso Land retail and entertainment concept coming to UK
Experience-led retail destination is coming to Oxford Street
GM’s core profit rises 22% on strength of pickup-truck business
By Kalea Hall Oct 20 (Reuters) - General Motors’ third-quarter results easily beat analyst expectations on the back of resolute shoppers who continue to spring for pricey pickups and SUVs. The company on Tuesday said quarterly earnings before interes...
GM's core profit rises 22% on strength of pickup-truck business
General Motors' third-quarter results easily beat analyst expectations on the back of resolute shoppers who continue to spring for pricey pickups and SUVs.
Disney Names Carol Choi Asia Pacific President as Luke Kang Retires
Disney names Carol Choi Asia Pacific president as Luke Kang retires after 16 years, effective Dec. 1.
Toyota RAV4 review: boringly good, buyers can't get enough
I drove the 2026 Toyota RAV4. It's the perfect antidote to high gas prices and looks like everything else on the road. Good luck finding one to buy.
Walmart rolls out new bundle combining Walmart+, Sam’s Club Plus
Walmart shoppers can now get Walmart+ and Sam’s Club Plus together for $120 a year, nearly $100 less than buying both memberships separately.
Sensor Tower data shows the yawning gap between GTA 6 and everything else
In terms of preorder numbers, Rockstar's game is 148% head of 2022's Call of Duty: Modern Warfare 2 at this point from launch
LACMA, Perrotin, the new Metro and now the Brick: Todd Gray is having a banner year
Todd Gray has a solo show opening at the Brick on Oct. 18 — the cap on a banner year including a LACMA commission, a solo show at Perrotin and a public art piece for the Wilshire/La Cienega station for the D line.
Would Trump accept GOP midterm losses? 7 in 10 Americans doubt it.
A Post-ABC News-Ipsos poll finds broad confidence that votes will be counted accurately, but deep doubt that the president would accept the results if Republicans lost.
The Data Dive: Steve Kornacki on how Susan Collins could transcend Trump in Maine
Seeking re-election in a blue state, the longtime Republican senator is relying on her personal brand to defy political gravity — again.
Lukashenka optimizes the National Academy of Sciences of Belarus
On October 19, Alyaksandr Lukashenka signed Decree No. 367 "On the Activities of the National Academy of Sciences of Belarus," which liquidates, reorganizes, and alters a number of...
Xbox 'Business Strategist' Claims Video Game Industry Is 'Pretending to Not Use AI,' Deletes Twitter Account After Deluge of Replies
An Xbox staff member went viral this week for taking to social media to tell "the truth that nobody wants you to know": that the video game industry is "pretending" to not use AI.
Where to watch Tennessee-Duke basketball: TV, channel, streaming
Tennessee basketball will play Duke on Tuesday. Here is how to watch, including time, channel, TV schedule and streaming info.
$42 million Purdue donor wants support for Black and Hispanic students
McDonald's millionaire and Purdue alum Roland Parrish says, \
Democrats Demand Tougher Standards for Companies Running Medicaid Systems
A year after launching an inquiry into companies, including Deloitte, that receive billions in taxpayer dollars to build complex computer systems determining Medicaid eligibility, senators are urging the federal government to impose stricter rules.
The AI industry’s race for influence includes $100 million in campaign cash
Leading AI companies have set up political action committees to support both Republican and Democratic candidates in the midterm elections. The effort by…
After Larson's loss, CT's 1st District will elect a new representative
Luke Bronin won the Democratic primary and goes into the general election with the upper hand. He faces Republican Amy Chai on Nov. 3.
Brenda Lucas: Community news for Tuesday, Oct. 20
Click for community news in the Huntington, West Virginia, and Tri-State area.
GDC Festival of Gaming 2027 moves to four-day format to "create a higher quality, more focused and valuable experience"
"We're concentrating programming and opportunities during the days when the community is most active," say organisers
The key health care ballot measures we’re watching in the midterms
State fights over issues like transgender rights and Medicaid offer clues to where Americans stand on contentious health matters.
Tasteless Democratic ads highlight need for civility in politics
Give voters the information they need and leave the inappropriate theatrics out of it.
Tasteless Democratic ads highlight need for civility in politics
Give voters the information they need and leave the inappropriate theatrics out of it.
Columbia, Max Planck Team Up on Fusion Energy Science
The new Max Planck Columbia Center will have a total budget of $13.3 million over its five-year term
Do Democrats have inflated expectations for the midterms? Examining the case
Democrats are hungry for a blue wave in the November election, and a series of recent polls has them thinking they could pull off victories in some deeply red territory that would have seemed unthinkable a few months ago.
‘Oz’ Creator Tom Fontana to Showrun Vatican Drama Series Based on ‘The Devil’s Business’ Book as Fabel Entertainment Scores Rights (EXCLUSIVE)
“Oz” creator Tom Fontana is set to create and showrun a new Vatican drama series based on Emanuele Midolo’s forthcoming novel “The Devil’s Business” after Fabel Entertainment scored book rights. “The ...
ARK Invest Bets One Business Can Lift Tesla Stock to $4,400
ARK Invest’s open-source model values Tesla at about $4,400 per share in 2031, with robotaxis at 80% of enterprise value.
Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)
mIRage-LS - Multimodal submicron IR imaging & spectroscopy for life science research
The mIRage-LS combines sub-500 nm O-PTIR with co-located fluorescence microscopy for advanced life science research.