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AMN Healthcare Research Links Hospital Digital Investment to Better Patient Experience
/PRNewswire/ -- New proprietary research from AMN Healthcare, the leader and innovator in total talent solutions for healthcare organizations, examines the...
Matt LaFleur Puts Packers on Notice After Week 4 Turnovers
Following a sloppy victory over the Tampa Bay Buccaneers, the Green Bay Packers' head coach threatened to bench players who fumble the football.
Into the Slaughterverse: How ‘Something Is Killing the Children’ cut into film, TV, and books
Into the Slaughterverse! ‘Something Is Killing the Children’ creator James Tynion IV talks expanding his comics into a horror universe with a film, animated TV show, and prequel novel.
Block Club Chicago’s Free South Side Health & Wellness Fest Is Coming to Chatham
Join Block Club and community partners on Nov. 7 for activities and resources to help address health equity gaps. Join a fun run with Joabe Barbosa, get a free meal and more.
We need CI-132 to keep politics and money out of our courts
Please join me in voting yes on CI-132 this November so we can protect our tradition of elected judges based on their record and qualifications and keep politics out of
A ‘telenovela of US politics on a two-year delay’: Expert reacts to Brazil election results
Oprah Winfrey taps a 'riveting' debut novel for her book club
Oprah Winfrey has chosen Amanda Rizkalla's debut novel, “Hungered,” as her new book club pick. The novel, released in May, follows a 12-year-old girl navigating poverty and family struggles. Winfrey
Oprah Winfrey taps a 'riveting' debut novel for her book club
Oprah Winfrey has chosen Amanda Rizkalla's debut novel, “Hungered,” as her new book club pick | 830 WCCO
AIAS+ 2026 Brings Leading Scientists to San Francisco to Explore How AI Is Changing Scientific Discovery
The Tianqiao and Chrissy Chen Institute will bring leading scientists, AI researchers, engineers and innovators to San Francisco November 5–7 for AIAS+ 2026: AI Advancing Science & Society, a three-day symposium focused on one of the most consequential questions facing research today: How can artificial intelligence help scientists move beyond analyzing what is already known and accelerate new discovery?
OVG To Operate, Book Riverview Health Arena in Noblesville, Ind.
The City of Noblesville, Indiana, has announced that Oak View Group will operate and book the 3,400-seat Riverview Health Arena at Innovation Mile. The arena
Belcan Receives Pratt & Whitney Premier Awards for Overall Excellence in Business Management and Technology & Innovation
Pratt & Whitney has recognized Belcan, a Cognizant company, with a Premier Award for performance in 2025 and overall excellence in Business Management and Technology & Innovation.
WEATHER REPORT: Notre Dame Fighting Irish vs Stanford Cardinal
This might be the most perfect weather we get this year at Notre Dame (unless you love snow in November).
American Journal Of Public Health Study Examines Political Differences In Perceptions Of Vaccine Safety And Effectiveness
Vaccine perceptions can influence acceptance and uptake. Dr. Dror Walter, with the Department of Communication at Georgia State University in Atlanta, and colleagues examined these perceptions using data from a national probability sample of 1,763 US adults surveyed in November 2024.
Greg Hinz: Can the brave new world of AI be tamed?
Pritzker’s team says they’re pondering AI legislation when the General Assembly returns in November. But real solutions will require not state but federal, even international action.
Greg Hinz: Can the brave new world of AI be tamed?
Pritzker’s team says they’re pondering AI legislation when the General Assembly returns in November. But real solutions will require not state but federal, even international action.
Iowa's 3rd Congressional District candidates sound off on economy, war
Republican U.S. Rep. Zach Nunn faces a challenge from Democrat Sarah Trone Garriott in the Nov. 3 midterm election. Meet the candidates.
Ohio Early Voting Begins With US Congress Control on the Line
By Richard Cowan MEDINA, OHIO, Oct 6 (Reuters) - Early voting begins on Tuesday in Ohio, where the winners of November's midterm elections will help determine whether Republicans or Democrats control the US Congress for the next two years, given the state has one Senate seat and two House seats ...
Jeffrey Archer, UK novelist and former politician jailed for lying in libel case, dies at 86
Jeffrey Archer, a British bestselling author who sold more than 300 million book copies in his career and a former politician who was jailed for lying in a high-profile libel case, died Monday.
Is Earth in danger if Betelgeuse goes supernova? | BBC Sky at Night Magazine
Betelgeuse, the red giant that form's Orion's shoulder, could go supernova soon. But what will happen and is Earth in danger when it does?
Democrats could win majority of governor’s offices for first time in 16 years
As the political prospects for Republicans worsen ahead of November’s midterm elections, the GOP is increasingly playing defense over its yearslong grip on state governments. That’s particularly true for gubernatorial elections, as Democrats could win a majority of governorships for the first time since 2010. Currently, Republicans boast a 26-24 gubernatorial advantage over Democrats. This […]
The Senate is up for grabs. Plot each party’s best path to winning
As many as 10 key Senate races identified by CNN that are on the ballot in November will likely determine which political party controls the chamber.
October 2026 PS Plus Essential Games Available to Download Now
You can download until 2nd November
Missouri’s 6th Congressional district: What to know about the candidates running in November
A Democrat, a Republican and a Libertarian are running to fill the seat vacated by the retiring Sam Graves, which covers most of the upper portion of Missouri.
Kansas' 3rd Congressional District: What to know about the candidates running in November
Republican Eric Jenkins and Libertarian Steve Hohe are attempting to unseat Democratic U.S. Rep. Sharice Davids in Kansas’ 3rd Congressional District, which covers the majority of the Kansas City suburbs.
Salsa classes seek to spread Hispanic culture, boost campus life
The free weekly dance classes are at 1 p.m. Thursday in the Science and Engineering Innovation and Research Building.
The Business Behind the Blooms
Natalie Noll ’26 is putting her economics degree to work as the founder of Nova Flora, using lessons in pricing, markets and operations to build her floral business.
Vikings Guard Donovan Jackson Likely Out Rest of 2026 Season
The Minnesota Vikings will likely be without offensive guard Donovan Jackson as he tore his meniscus.
Switch 2 Japanese-Language System ‘Choose-Your-Game Bundle’ launches November 12 in Japan
Nintendo will release the Switch 2 Japanese-Language System (Japan Only) Choose-Your-Game Bundle on November 12 in Japan for 63,980 yen, the company announced.
Best-selling British author and fomer Conservative politician Jeffrey Archer dies, aged 86
The author, whose novels sold over 300 million copies, had hoped to become mayor of London, but several scandals ended his political career.
Polling shows ban on trans girls in girls' sports could pass in November
Washington state voters will soon weigh in on a ballot measure to ban transgender girls from playing on girls’ school sports teams. The initiative is controversial, but national and local polling suggest it could have enough silent support to pass.
Try the new demo for Warhammer Survivors now!
Bring bullet heaven to the worlds of Warhammer this November.
News | Populate hires director of science and innovation for £1 billion London Cancer Hub project
Angela Kukula was chief executive of life sciences cluster organisation MedCity
A simple guide to the US midterms
US voters will head to the polls on 3 November in a ballot that could have a major impact on Donald Trump’s presidency.
Wisconsin voters to decide limits on governor’s partial veto power
LA CROSSE, Wis. (WXOW) – Wisconsin voters will see three proposed constitutional amendments on their Nov. 3 ballot, including one dealing with the governor’s partial veto power.
UK author and politician Jeffrey Archer dies aged 86
Jeffrey Archer, the best-selling British novelist and former politician who was jailed for lying in a high-profile libel case, has died aged 86, his publisher HarperCollins said on Monday.
How Close Jeffery Simmons Thinks Titans Are to Winning Football
Despite an 0-4 start, the star defensive tackle insists Tennessee is on the brink of a breakthrough if they can finally master the art of forcing turnovers.
FSU becomes first college campus to install interactive Hope Booth to support student mental health
Florida State University has become the first college campus in the nation to install a Hope Booth, an innovative resource designed to expand access to
Yes on Prop 2: How We Can Get Money Out of Michigan Politics!
This November, Michiganders can vote yes on Prop 2 and get corporate spending — including by the data center industry — out of our politics.
Your ballot, your move: Early voting starts Oct. 6
By Kevin Hendricks, nm.news — New Mexico voters can start casting ballots Oct. 6 for the Nov. 3 general election. There’s no reason to wait in line on Election Day, or to walk into the booth guessing. Early voting opens Oct. 6 at county clerk offices. On Oct. 17 it expands to more locations across […]
Donovan Jackson to miss extended time
Vikings OG Donovan Jackson set to miss rest of regular season because of injury
Will R.I. voters, elected officials continue investing in life sciences?
Rhode Island starts in a strong position and has the ingredients needed for innovation and growth. What we don’t have yet is a long-term commitment, writes the CEO of the RI Life Science Hub.
Now Open! APSA Teaching & Learning Conference Awards and Travel Grants | Deadline: November 16, 2026 -
Now Open! Apply for TLC Travel Grants & Awards Michael Brintnall Teaching and Learning Award APSA Award for Teaching Innovation | Travel Grants Deadline: November 16, 2026, 11:59PM ET Join political science teacher-scholars and students [...]
Now Open! APSA Teaching & Learning Conference Awards and Travel Grants | Deadline: November 16, 2026 -
Now Open! Apply for TLC Travel Grants & Awards Michael Brintnall Teaching and Learning Award APSA Award for Teaching Innovation | Travel Grants Deadline: November 16, 2026, 11:59PM ET Join political science teacher-scholars and students [...]
Five Plays: NC State First Quarter
Louisville lost another football game on Saturday. They also lost another game that they should have won. Penalties had been a major issue for this team, but they replaced that issue with turnovers this time around. But the biggest issue remains, and that issue is blown coverages by the secondary. For the second straight week, […]
Carnell Tate Not Letting First-Half Blunder Ruin Historic Day
The rookie receiver overcame a costly turnover to deliver a dominant 145-yard performance, signaling a new era of offensive consistency for Tennessee despite a narrow loss.
Hello from Seattle: XBOX FanFest Comes Home November 12
Seattle, we’re coming home. XBOX FanFest is coming on Thursday, November 12, 2026 - find out what to expect and how to attend inside.
Your Vote 2026 Maine Calling candidate interview: Bobby Charles, Republican for governor
Maine Calling host Jennifer Rooks interviews Republican gubernatorial candidate Bobby Charles ahead of the November election.
Pokémon GO Halloween 2026: Part One
Pokémon GO’s Halloween 2026 Part One event runs from October 27 at 10:00 a.m. to November 1 at 10:00 a.m. local time, bringing three new costume Pokémon: Pikachu wearing a hat and capelet, Zubat wearing a top hat, and Sinistea wearing a bow! Expect spooky wild encounters, costume raids, and trick-or-treat surprises that can reward […]
Democrats expand target list as polls point in their favor
Democrats are expanding the number of Republican-held House seats they hope to flip in November as polling moves in their favor ahead of the midterm elections. The Democratic Congressional Campaign Committee announced Monday that it added six candidates to its “Red to Blue” program, bringing the total to 46. The program provides candidates with strategic […]
After a legal battle, Marylanders will vote on future redist...
Marylanders will vote on Question 3 in November after the state’s highest court cleared a revised redistricting amendment for the ballot.
Former press secretary Karoline Leavitt lands her next gig: Fox News contributor
Former White House press secretary Karoline Leavitt is joining Fox News as an on-air contributor starting November 1.
FSU data scientist receives NSF CAREER Award to develop AI model to analyze complex numerical data at scale
A Florida State University artificial intelligence and data scientist has earned one of the most prestigious early career faculty awards to develop a new
Misericordia University to Host Healthcare Symposium with Presenting Sponsor Geisinger
Misericordia University’s College of Health Sciences and Education, with Geisinger as Presenting Sponsor, will host the 2026 Healthcare Symposium, “Connected Care: Aligning Education, Innovation & Community Health,” on Friday, Oct. 23, from 8 a.m. to 5 p.m. in Lemmond Theater on the University’s Dallas campus.
Lawrence brothers take on missing ’90s stars in graphic novel, ‘The Lawrence Brothers Detective Agency’
Joey Lawrence and his brothers, Matthew and Andrew, take on missing ’90s stars and nostalgia prisons in the new graphic novel, ‘The Lawrence Brothers Detective Agency.’
Todd Promenade returns on Saturday, Nov. 7
TODD — The Todd CommUnity Dance organizers are pleased to announce the second Todd Promenade event, featuring an afternoon of square dance calling, flatfoot dance, and playing music for dances
Fear is bigger than ever… and Zero Latency VR has the science to prove it
MELBOURNE, Australia — Zero Latency VR, the world’s largest and most innovative immersive VR network, is celebrating a double Halloween anniversary: three years since the launch of Outbreak, …
PRO SHOP RAISES $24 MILLION SERIES B TO ACCELERATE NEXT PHASE OF GROWTH ACROSS MEDIA, ENTERTAINMENT AND COMMERCE
/PRNewswire/ -- Pro Shop, the innovative media platform connecting golf with mainstream culture, today announced the closing of a $24 million Series B...
Former press secretary Karoline Leavitt lands her next gig: Fox News contributor
Former White House press secretary Karoline Leavitt is joining Fox News as an on-air contributor starting Nov. 1.
Former press secretary Karoline Leavitt lands her next gig: Fox News contributor
Former White House press secretary Karoline Leavitt is joining Fox News as an on-air contributor starting November 1 | WWJ Newsradio 950
What does Spain's snap election mean for the EU?
Spain's snap election on 29 November could cost progressive European forces their last government in a large member state, tilting EU power towards the right and pushing socialists into opposition mode.
The AFC road to L.A. may go through Duval
As the stadium in Jacksonville undergoes renovations, the Jaguars will play only six games there in 2026.
Anyone can listen to PENN Entertainment's Q3 call on Nov. 5.
PENN will post results at 7 a.m. ET, then hold a 9 a.m. ET call and simultaneous webcast; a replay will be available for 30 days on its website.
Gambit's Election Guide Fall 2026
This fall’s elections are fast approaching. Early voting starts Oct. 20 and will run through Oct. 27 (excluding Sunday, Oct. 25), and Election Day is scheduled for Nov. 3.
Top crypto group to pour millions into bipartisan slate of House races after key legislation stalls
WASHINGTON (AP) — A top cryptocurrency campaign organization is unveiling a bipartisan list of House members that it will support in the November midterms, as o
Conference to Explore Alternatives to Coercive Mental Health Care
The 18th annual Critical Voices Network Ireland (CVNI) conference will take place at University College Cork November 12 and 13, bringing together speakers and participants to explore critical and alternative responses to human distress.
Indonesia and China to strengthen science and education cooperation
Indonesia and China plan to expand cooperation in higher education and science to advance innovation and technology adoption.
Innovation That Solves: From Business Needs to AI Solutions
Targeted AI innovation transforms business challenges like hydrocarbon compliance into effective technological solutions, writes Jorge Mandujano.
Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for opening your Chartbook email. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care: The largest crunch has come in Federal government, which has shed 2.7 m jobs. Source: tchouvkov on Twitter Tech is struggling. [ Joey Politano 🏳️🌈@JosephPolitano The US tech sector continues bleeding jobs in official data released today—overall, employment decreased by 17k last month and is down 69k over the last year That's nearly as bad as the worst of the 2024 tech-cession, and much worse than the 2022 boom or even pre-2020 norms 12:42 PM · Oct 2, 2026 · 15.2K Views 15 Replies · 47 Reposts · 390 Likes ](https://x.com/JosephPolitano/status/2106001807847940232?s=20) The new jobs are all for women. [ Justin Wolfers@JustinWolfers I'm not sure who saw this coming, but so far nearly all the jobs created during the second Trump administration have gone to women. 1:09 PM · Oct 2, 2026 · 33K Views 70 Replies · 146 Reposts · 644 Likes ](https://x.com/JustinWolfers/status/2106008723533533601?s=20) Meanwhile, real wages are being eaten up by modest over-target inflation. [ Heather Long@byHeatherLong The financial pain is real: Wage growth fell to 3% (y/y) in September. That's the lowest in 5 years. Wage growth: 3% Inflation: ~3.4% Inflation has eaten up all wage gains for the average worker since April. Many people are having to make hard choices about what to buy and what … 1:24 PM · Oct 2, 2026 · 37K Views 24 Replies · 275 Reposts · 533 Likes ](https://x.com/byHeatherLong/status/2106012367712620728?s=20) HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $60. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Elmer Bischoff, Bathers, 1960 Americans are disillusioned with higher ed. For contributing subscribers only. Subscribe Where the Chernobyl radiation went. h/t Simon Kuestenmacher aka simongerman600 How Lenin’s love of literature shaped the Russian Revolution - Tariq Ali This, then, was the intellectual atmosphere in which Lenin came of age. His father, a highly cultured conservative, was the chief inspector of schools in his region and much respected as an educationalist. At home, Shakespeare, Goethe and Pushkin, among others, were read aloud on Sunday afternoons. It was impossible for the Ulyanov family – “Lenin” was a pseudonym adopted to outwit the tsarist secret police – to escape high culture. At high school, Lenin fell in love with Latin. His headteacher had high hopes that he might become a philologist and Latin scholar. History willed otherwise, but Lenin’s passion for Latin, and taste for the classics, never left him. He read Virgil, Ovid, Horace and Juvenal in the original, as well as Roman senatorial orations. He devoured Goethe during his two decades in exile, reading and rereading Faust many times. Lenin put his knowledge of the classics to good use in the time leading up to the October revolution of 1917. In April of that year, he broke with Russian social-democratic orthodoxy and, in a set of radical theses, called for a socialist revolution in Russia. A number of his own close comrades denounced him. In a sharp riposte, Lenin quoted Mephistopheles from Goethe’s masterwork: “Theory, my friend, is grey, but green is the eternal tree of life.” Source: The Guardian Elmer Bischoff, The River, 1953 If you’ve scrolled this far, you know you want to click: Subscribe
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
Novant Health hiring event kicks off in Greenville
FOX Carolina's Scottie Hunter has the details.
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