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Raptors 'expect the unexpected' from Cavaliers in Game 4
The Toronto Raptors understand they must be ready for anything Sunday afternoon when they attempt to even their Eastern Conference first-round series with the visiting Cleveland Cavaliers.
Cavs won’t face Immanuel Quickley in the playoffs
Toronto’s starting point guard will not face Cleveland in the first round of the playoffs.
Kalshi blocked Gannon Van Dyke, soldier charged in Polymarket trades
Gannon Van Dyke was blocked by Kalshi but got onto Polymarket and allegedly profited off trades informed by military secrets.
Blue Jays’ George Springer Replacement Offers 5-Word Response On Health Setback
The Toronto Blue Jays’ outfield veteran revealed that he is still dealing with a scary health situation after treatment.
Toronto 'Godspell' Doc 'You Had To Be There' Acquired By Greenwich Ent.
The 1972 'Godspell' doc 'You Had To Be There,' about the show that launched Gilda Radner, Martin Short and more has been acquired by Greenwich Ent.
Canada’s biotech paradox: strong science, weak scaling
Canada produces a steady stream of biotech startups built on credible academic research. Universities and hospital research centers in Toronto, Montreal, and Vancouver generate discoveries that move quickly into company formation. Early-stage activity is not the constraint. The difficulty tends to surface later, when those companies try to grow.
'Heated Rivalry' Author Rachel Reid to Receive THR Canada Honor
Reid will receive the Changemaker Award and take part in an onstage conversation May 28 in Toronto.
A Look At Sphere Entertainment (SPHR) Valuation As Upgraded Earnings Outlook Lifts Momentum
Momentum shift puts Sphere Entertainment in focus Recent favorable revisions to earnings estimates and a strong momentum score have pushed Sphere Entertainment (SPHR) onto more investors’ radars, as the stock’s performance has differed from both the broader market and its media peers. See our latest analysis for Sphere Entertainment. Despite a 2.8% decline in the latest session and a 4.4% 7 day share price pullback, Sphere Entertainment’s 30 day share price return of 18.8% and very large 1...
Union takes legal action against Build a Rocket Boy over alleged data privacy violations
IWGB union cites monitoring software installed onto employees' devices as violating "both data protection laws and the workforce's basic dignity"
PGA TOUR and Front Office Sports Announce Content Agreement
The multi-year deal will bring fans closer to the business stories that dominate conversations through content from key PGA TOUR moments.
Scientists sculpt Einstein onto a crystal using only light
A light-sensitive crystal is opening the door to a new era of “light-written” technology. Arsenic trisulfide can be reshaped and permanently altered using simple light, creating ultra-fine optical patterns without expensive manufacturing tools. Scientists even etched a nanoscale portrait of Einstein and high-density patterns that could act as secure optical signatures. This breakthrough could power everything from advanced sensors to next-generation AR devices.
NBA Playoffs: Atlanta Hawks stun New York Knicks to level series as Minnesota Timberwolves end Denver Nuggets' win streak
Cleveland Cavaliers trio of stars Donovan Mitchell, James Harden and Evan Mobley stepped up in 115-105 win over Toronto Raptors that secured a 2-0 lead in their Eastern Conference first-round playoff series; watch the 2026 NBA playoffs live on Sky Sports
'It's a tragedy:' New Mexico family loses home, business and dog in fire
"Nobody knew if we were here or not—so people were looking for us because they were concerned that we were inside," Emilia Montoya told KOAT.
A game of split-second decisions: Putting health and human performance to the test
When athletes step onto the field, reacting a fraction of a second too late can be the difference between making a play and sustaining an injury. At the University of Tennessee at Chattanooga, faculty in the Department of Health and Human Performance (HHP) are studying what drives those split-second decisions and how sleep, mental health and cognitive processing affect performance and injury risk.
A Movie Lover Argues Alamo Drafthouse Blew It
Sony-owned chain forces people onto phones despite once-strict ban, writes David Ehrlich
Caitlin Clark Prioritizes Health As WNBA Banks on Her Availability
WNBA broadcasts during the 2025 season averaged 969,000 viewers across ESPN networks, Ion, and CBS—a modest 3% increase in viewership compared to 2024.
Storylines abound as Scottie Barnes, Raptors open series at Cavs
Success came quickly for Toronto Raptors power forward Scottie Barnes, who won the Rookie of the Year award and got a taste of the playoffs four years ago.
Family business pivots to aid special needs child
Stephanie Chain pulls a fresh pair of disposable gloves from a box, snapping them onto her practiced hands. Gently, she lines up pieces of crispy toast in neat rows. Nearby,
Can the Cavs Set Their Playoff Tone Against the Raptors?
The 2026 NBA playoffs have taken shape, and the Cleveland Cavaliers look to right the wrongs of years past. This year, the wine and gold will face an old playoff foe in the Toronto Raptors, a team the franchise has familiarity with from its days with LeBron James leading the charge. However, this is a […] The post Can the Cavs Set Their Playoff Tone Against the Raptors? appeared first on The Lead.
10 dinosaur science books recommended by a paleontologist
Steve Brusatte, author of The Rise and Fall of the Dinosaurs and The Story of Birds, recommends 10 dinosaur books to dig into
Where to watch Toronto Blue Jays vs. Milwaukee Brewers: Live stream, TV channel, odds for Thursday, April 16
Vladimir Guerrero Jr. and the Blue Jays close out their three-game series with the Brewers.
Water on Mars? Scientists discover 'bathtub ring' which may reveal contours of ancient ocean
Like Earth and the solar system's other planets, Mars formed roughly 4. 5 billion years ago.
Water on Mars? Scientists discover 'bathtub ring' which may reveal contours of ancient ocean
Like Earth and the solar system's other planets, Mars formed roughly 4.5 billion years ago. Early in its history, Mars was warmer and wetter than the cold and arid place it is today.
‘Indiana Jones Of Paleontology’ To Open Science Center For Teens In Washington Park
University of Chicago professor Paul Sereno hopes his space, Scitopia Chicago, inspires the next generation of scientists.
UChicago paleontologist announces plans for Washington Park science center focused on teen education
The more than 45,000-square-foot center planned for the Washington Park neighborhood will be free for teens across the state to visit.
Cavaliers vs. Raptors injury report and preview entering NBA playoffs
Injury news will be worth watching as the Cleveland Cavaliers and Toronto Raptors meet in the first round of the NBA playoffs.
Toronto Raptors vs. Cleveland Cavaliers - Live Score
View the Toronto Raptors vs. Cleveland Cavaliers game played on May 03, 2026. Box score, stats, play-by-play timeline, highlights, odds & more
GLP-1 medicine improves liver health independent of weight loss, study finds
Researchers at Toronto's Sinai Health have found that semaglutide—the active ingredient in popular weight loss drugs that mimic the gut hormone GLP-1—acts directly on a subset of liver cells to improve ...
Hold Onto Moon Joy
Artemis II humanized the moon. Can we capture the same sentiment back on Earth?
White Sox deal Lenyn Sosa to Toronto
The infielder is shipped out for a lottery ticket and loose change
Exclusive: Manulife Investment Management eyes Cellnex Swiss business, sources say
Spain's Cellnex is in talks to sell its stake in its Swiss unit to Toronto-listed Manulife Financial Corporation's investment management unit, according to two sources with knowledge of the situation.
How Artemis 2 commander Reid Wiseman saved the mission's moon mascot: 'It's hard not to love this little guy. I can't let Rise out of my sight'
"I stuffed that little guy in a dry bag we had in our survival kit, and hooked the bag onto my pressure suit."
Toronto Raptors vs. Cleveland Cavaliers - Live Score
View the Toronto Raptors vs. Cleveland Cavaliers game played on April 18, 2026. Box score, stats, play-by-play timeline, highlights, odds & more
Blue Jays Facing Vladimir Guerrero Jr. Decision After Unfortunate News
The Toronto Blue Jays were dealt an unfortunate blow against the Tampa Bay Rays.
Up a ramp, finally off the big river
KALTAG — A few hours ago, Forest Wagner and I shoved our loaded bikes up a ramp of snow and onto Front Street.
Jesuit-Rummel winner clinches district title as fast-working pitcher overcomes early struggles
After each pitch, Maes Martin quickly took the return throw from the catcher and stepped back onto the rubber.
⚠️ Concern for Mbappé! Not training with the squad after eyebrow stitches
Real Madrid completed training this Sunday with an absence that raised alarm bells, although the club is conveying complete calm. According to several media outlets, Kylian Mbappé did not go out onto...
Sooo ... About Last Night
Last night (Sat., April 11, 2026), Ultimate Fighting Championship (UFC) ventured forth to Kaseya Center in Miami, Florida for UFC 327. Was this the deepest numbered event since UFC 300? Maybe Jon Anik was onto something! There were great fights from top to bottom, like Kelvin Gastelum vs. Vicente Luque on the early “Prelims” card. […]
Blue Jays add Silver Slugger winner to replace injured George Springer
Toronto had to find someone new.
High school sports results for Saturday, April 11, 2026
SATURDAY’S RESULTS Baseball NON-SECTION Albert Gallatin 4, Steel Valley 0 Toronto, Ohio 20, Carrick 0 Softball WPIAL CLASS 5A Section 2 Kiski Area...
Unusual airborne toxin detected in the U.S. for the first time
Scientists searching for air pollution clues stumbled onto something unexpected: toxic MCCPs drifting through the air for the first time in the Western Hemisphere. The likely source—fertilizer made from sewage sludge—points to a hidden route for contamination.
Fallout of War Piles Economic Pain Onto Europe’s Political Stress
Europe is finding itself on the outs with Russia, China and the U.S., in what’s amounting to its very own “Mean Girls” moment.
Italy's UniCredit says no plans to liquidate Russian business
UniCredit said on Friday it had no plans to liquidate its Russian business or return the banking licence held by its local subsidiary, which the Italian lender has held onto during the Ukraine conflict.
Proto-mammals laid eggs, paleontologists finally confirm
Lystrosaurus fills in a major evolutionary gap.
North of North Creators to Receive WIE Canada Honors
The ‘North of North’ indigenous comedy creators and showrunners will receive the Breakthrough Award on May 28 in Toronto.
Sterling ticks higher, remains driven by Middle East developments
The pound inched higher on the dollar on Thursday and held onto the bulk of U.S.-Iran ceasefire-inspired gains the previous session, though with that deal looking fragile it failed to climb any further.
Scientists discover hidden gut trigger behind ALS and dementia
A new study reveals that gut bacteria may play a key role in triggering ALS and frontotemporal dementia. Harmful sugars produced by these microbes can spark immune responses that damage the brain. This breakthrough explains why some genetically at-risk people develop the diseases while others don’t. Even more promising, reducing these sugars improved brain health in experiments, hinting at new treatment possibilities.
Yoshinobu Yamamoto does it again, trouncing the Blue Jays in another Dodgers victory in Toronto
From Olympic Gold to Founder: Allyson Felix’s Next Chapter
Olympic champion turned investor Allyson Felix discusses how she is helping reshape the future of women’s sports through investing & brand-building.
Ella Duggan Promoted to Branch & Business Development Manager at The Merrimack
Merrimack County Savings Bank (The Merrimack) congratulates Ella Duggan on her promotion to Branch & Business Development Manager. In this role, Duggan will oversee branch operations while continuing to serve Contoocook and its small business community. “Ella’s promotion is well-earned and reflects her consistent growth over the years,” said Michelle Olivier, RVP Branch Manager at The Merrimack. “I’m […]
Dodgers Reveal Reason for Will Smith Benching
Dalton Rushing is starting in Will Smith's place in the Los Angeles Dodgers' Monday afternoon game at the Toronto Blue Jays.
Toronto Tempo vs. Minnesota Lynx - Live Score
View the Toronto Tempo vs. Minnesota Lynx game played on May 01, 2026. Box score, stats, odds, highlights, play-by-play, social & more
Will entertainment-led Rock League be future of curling?
Rock League, the first-ever professional curling league, starts in Toronto later on Monday, with six mixed-gender global franchises playing in an unusual format.
Will entertainment-led Rock League be future of curling?
Rock League, the first-ever professional curling league, starts in Toronto later on Monday, with six mixed-gender global franchises playing in an unusual format.
Is it time for both parties to bail on Colorado’s political nominating system?
Cracks are beginning to appear in Colorado’s political nominating system. Recently, Mario Nicolais, a formerly Republican-leaning pundit, and Doug Friednash, former Democratic legislator, have opined regarding the imminent demise of the caucus/assembly framework which controls partisan candidate selection. There has always been a legal detour around this process whereby candidates petition directly onto the ballot. […]
One year later: Jeffersontown business hit by EF-3 tornado continues to rebuild
One year later: Jeffersontown business hit by EF-3 tornado continues to rebuild
Steve Kitts, owner of JSO Wood Products, stands on newly installed flooring and under a new roof on the home of his business. The framed-out walls and no product inside the space is different from the...
Celtics beat Raptors 115-101 behind Tatum, Brown
Jaylen Brown scored 26 points, Jayson Tatum had 23 points and 13 rebounds and the Boston Celtics beat the Toronto Raptors 115-101 on Sunday. Neemias Queta had 18 points and seven rebounds, and Payton Pritchard scored 17 points for the Celtics, who won their third straight to move closer to clinching second place in the Eastern Conference. Ja'Kobe Walter led Toronto with 16 points, and Brandon Ingram and RJ Barrett each had 15.
Islanders fire coach Patrick Roy with 4 games remaining before playoffs, hire Peter DeBoer to replace him
The Islanders are making a coaching change while hanging onto the No. 7 seed in the NHL's Eastern Conference.
Blue Jays confirm brutal Alejandro Kirk injury news
Toronto will have to figure this out.
Here’s how NASA cleared the iPhone 17 Pro Max for astronauts on Artemis II
The iPhone 17 Pro Max made it onto Artemis II after NASA cleared it for spaceflight, with each astronaut using one to capture the mission.
Album Review: 6WA by BigXthaPlug & 600 Entertainment
BigXthaPlug spent eight months in Nashville making a country-rap album that debuted at No. 7 on the Billboard 200, put “All the Way” with Bailey Zimmerman at No. 4 on the Hot 100, got him a Rolling Stone cover, and filled arenas with Jelly Roll. And then he came back to Dallas, rounded up four of his signees, and made a gangsta-rap record with N.W.A’s Straight Outta Compton on the cover. 6WA is the second group release from 600 Entertainment, named after the 600 block of Meadowridge Street in Ferris, Texas, where BigX and his people grew up. The whole thing is loaded with West Coast samples. From N.W.A.’s “8Ball,” Eazy-E’s “Real Muthaphuckkin G’s” and “Boyz-N-The-Hood,” Ice-T’s “6 in the Mornin’,” Snoop Dogg’s “Nuthin’ but a ‘G’ Thang” and more. BigX is staking his name on the lineup he built—Rosama, MurdaGang PB, Yung Hood, KevanGotBandz, KaineMusic—and claiming a lineage from 1,400 miles away while insisting Dallas is its own thing. A million dollars in cash, split and handed straight to his mother. That’s the first place BigX goes on “From the Bottom.” He’d probably still be in the streets if he didn’t have his son and daughter. He only started rapping to make life better for Carter. Couldn’t start his car back then, now people get starstruck at Starbucks, and he throws the whole field away in one sentence: “How you think we competin’? You on the same bag, I just made me some millions off country.” Goyard bags off a Nashville payday, and he wants you to know exactly how far he’s come from everybody else. “Safe to Say” does something similar but looser. It’s a straight Ice Cube “It Was a Good Day” flip, and BigX nails it. Wakes up, checks both phones, nobody’s locked up, kid accounts look good. Gets pulled over, only catches a warning. Pulls up on the squad to liquor, ladies, and haze. Rosama takes the second verse and matches him. Wakes up to his girl cleaning his cuticles, twins playing peekaboo, pays off his car, calls a cousin, sees the opps and they don’t trip. Lawyer calls, he beat his case. Rosama is the strongest voice in the 600 camp after BigX, and “Life of a Gangster” is why. Third person, riding low, blacked-out windows, snub-nose revolver. A character who chose sticking people up over selling dope. “Quick eraser like a number-two pencil.” He never breaks character, and his delivery drops lower and slower than anything he does on the group cuts, like he’s telling you something at a cookout that he probably shouldn’t. Then on “Long Live Fre$h” he’s a completely different rapper. “Short-bus diamonds, these bitches retarded,” wide-body Durango he can’t even park. That kind of range matters on a group record. MurdaGang PB’s best verse is on the title track. Feds at his door at 6 AM, cameras busted, flushing dope, ram truck putting everybody on the floor. Yung Hood on “The Hottest” just lays out four reasons to keep hustling. Who wants to be broke, women cost money, you need bail, and home has to be straight. It’s funnier and more honest than most rappers get when they’re trying to explain why they sell drugs. KevanGotBandz on “Ain’t Never Slowin’ Down” talks about his father getting caught on the dope while he’s sitting on $300K somewhere in the hills, which is a specific kind of guilt that doesn’t usually make it onto crew tapes. KaineMusic, the newest signee, takes the back half of “Who Dunnit” and introduces herself in third person—“Took flight just to show these hoes how to perform”—but it’s too short to know if she can hold a full song. The flex tracks fill the middle of the LP and mostly run together. “I Go” is Rosama and PB trading brands, guns, and food punchlines. Rosama’s “anemic, my iron tucked low in this shirt” is a slick gun bar, PB fires back with “.223 with a clip ‘bout as big as a toddler” and “I go Burger King, stay with that whopper.” Quick, funny sometimes, but it’s all shopping lists. “Dopeman” is a chant. “6ixer Party” brings Snoop Dogg, who does exactly what you’d expect Snoop Dogg to do. BigX contributes the night’s wildest overshare: “She say she brought a friend too, well, I’m tryna put sausage on her dental.” These songs move fast and don’t overstay, but three or four of them could trade verses and nobody would catch it. Midway through, The D.O.C. shows up for a spoken-word interlude. Tracy Curry. West Dallas native, former N.W.A affiliate, co-writer on a lot of the records getting sampled on this very album. He thanks BigX for the tribute and then gets direct: “This your time, this DFW time. You need to do it like we do it down here.” Leave bread crumbs so everybody behind you can eat. Keep God in your life. It’s fatherly and generous, and it does raise the question of whether 6WA follows that advice. The album borrows heavy. The cover art, the Eazy-E samples, “Amerikkka’s Most Wanted” opening with a direct “Boyz-N-The-Hood” lift, Yung Hood rapping “Flag on my left side, Crip until I die.” But the stuff that actually stays with you is Dallas. BigX talking about Pleasant Grove, Rosama calling himself a country boy, PB recounting a raid that could’ve been last Tuesday. The record smells most like itself when it smells like Ferris, Texas, and least like Compton. BigX on “The Hottest” says his father was the first person he knew who had chickens. Not the way rappers usually wave at the drug trade. He means his actual father, his actual family. On “600 Degrees,” Rosama compares his chopper’s stutter to a speech disorder, PB claims he still has the block on his back even after leaving the city. BigX closes that one saying he used to spin and smack, and now the plaques are platinum. Thirty-two minutes was right for this. Nobody overstays, Tony Coles and Rance and Charley Cooks keep the production punchy, and BigX gives his signees real room instead of crowding every song. 6WA doesn’t reinvent anything. Five rappers, good beats, short clock. Most of what they say you’ve heard before. Some of it—the million to his mother, the cuticles and peekaboo, the four reasons to hustle—you won’t forget. Solid (★★★½☆) Favorite Track(s): “Safe to Say,” “From the Bottom,” “The Hottest” Subscribe
Trump’s DOJ tells Trump he can hold onto government docs when he leaves office, contrary to Watergate-era law
A new memo from the Justice Department says President Donald Trump no longer has to follow a Watergate-era law barring him from holding on to presidential records when he leaves office.
Raptors, vying for playoff spot, take on depleted Grizzlies
With six games remaining in the regular season and a guaranteed playoff spot at stake, the Toronto Raptors are in desperate need of a strong finish.
One year later: Businesses still rebuilding in Jeffersontown after EF3 tornado
38 businesses in total were affected by the April 3rd tornado, which caused more than $100M worth of damage.
Sharing her passion for science
By Danielle Rush Communications Specialist, Indiana University Kokomo Hisako Masuda, Indiana University Kokomo professor of biochemistry, was honored by the Indiana Academy of Science (IAS) as its 2026 Distinguished Scholar. The award is given to an individual who is recognized by the IAS as having an exceptional record of scholarship. Recipients are selected from nominations submitted to its awards committee. “I was surprised,” said Masuda, who joined IU Kokomo’s faculty in 2013. “I feel there are many good scientists in the Academy, so I wasn’t expecting it at all.” Patrick Motl, dean of the School of Sciences, said the Academy recognizes up to one member per year, and that Masuda is the second or third IU Kokomo faculty member to receive the commendation. “Clearly this speaks to the strength of Dr. Masuda’s accomplishments in research and scholarship and that her work stands out amongst her peers in Indiana,” said Motl, who received the award in 2019. “Many of the institutions that participate in the IAS are undergraduate institutions or primarily undergraduate institutions, but even having that caveat, Dr. Masuda has built and maintains a very active research program in her lab, working exclusively with undergraduates. She is passionate about science and can share that passion with her students. To carry on a quality research program with so many students involved in so many projects is truly remarkable and I am glad that the IAS acknowledged that for Dr. Masuda.” The IAS specifically commended her for involving more than 50 undergraduates in her research in bacterial metabolism, genomics, and their phenotypic plasticity at IU Kokomo, and publishing 23 articles with many student co-authors. Masuda’s current work primarily focuses on biodegradation and chemical repurposing of nylon. Using soil bacteria, her lab studies bacterial biodegradation of nylon and other environmental pollutants. She applies principles of green chemistry while developing a method to convert nylon waste into other nontoxic polymers. In collaborative work with health scientists, her lab investigates gut microbiomes of Indiana native birds as well as human subjects in a clinical study. She became interested in converting plastic waste while earning her Ph.D. at Rutgers University, working on methods to remove environmental waste not using chemicals or other intrusive methods. She learned about Nylon 11, which is used in pipes for transferring oil, interior components for cars, catheters, and in other industrial hard plastics. Nylon 11 is nontoxic, she added, so it is safe to include students in the research. “Those are considered to be nonbiodegradable, and have to go to a landfill,” she said. “I thought if we could come up with a way to biodegrade it, that would make some kind of impact.” Eventually, she wants to develop a product that would convert nylon waste to something useful, and to reduce waste and microplastics in the environment. “That would be my goal at some point, that we can make that change, and also make people more aware of their use of plastics,” she said. “I hope students stop to think about what we can do as scientists to address issues currently impacting us.” She appreciates the IAS for its support of scientific research at Indiana institutions, and IU Kokomo and the School of Sciences for providing funding for students to attend the Academy’s annual meeting. She added that IU Kokomo has also supported her research with funding from the School of Sciences and Academic Affairs. “Without that, I couldn’t do my research,” she said. Masuda has also earned a Senior Research Grant from the IAS, IU Kokomo’s Distinguished Research Award, and the IU Kokomo Junior Faculty Annual Research Award. She is a Fellow of the Indiana Academy of Science. Education is KEY at Indiana University Kokomo.
Business as Usual at NFL Network as ESPN Era Begins
While NFL Network now falls under ESPN ownership, the former league-owned network largely remained the same on Wednesday.
Vladimir Guerrero Jr. to host baseball camps for FlexWork Sports baseball camps
Vladimir Guerrero Jr. committed his future to Toronto.
Hands-on: Anker's new Nano Power Strip will be a perfect fit in your desk setup
Today, Anker is releasing its new Nano Power Strip, initially unveiled at CES 2026. It clamps onto the side of...
Under Armour, Kontoor Brands, PENN Entertainment, Deckers, and Carnival Stocks Trade Up, What You Need To Know
A number of stocks jumped in the morning session after investors priced in a potential de-escalation of the conflict in Iran alongside reassuring commentary from the Federal Reserve on interest rates.
UAH Earth System Science Center scientist selected as U.S. Drought Monitor author
A University of Alabama in Huntsville (UAH) scientist is stepping onto the national stage to help shape how the country understands and responds to drought. Jonathan Case, a principal research scientist for the Earth System Science Center at UAH, a part of The University of Alabama System, has been selected as one of two new NASA-affiliated authors for the U.
Under Armour, Kontoor Brands, PENN Entertainment, Deckers, and Carnival Stocks Trade Up, What You Need To Know
What Happened? A number of stocks jumped in the morning session after investors priced in a potential de-escalation of the conflict in Iran alongside reassur...
Masai Ujiri joins ownership group of WNBA's Toronto Tempo
Former Raptors president Masai Ujiri has joined the ownership group of the city's new WNBA franchise.
Charleston Open Director Says Equal Prize Money Made Business Sense
The tennis tournament will pay women a $2.3 million purse this year, more than twice as much as last year.
Duke radio announcer called for technical foul on UConn after game-winner
Duke play-by-play announcer David Shumate said a technical foul should have been called on Malachi Smith, who allegedly ran onto the court from bench.
Scientists Stunned: Colossal Eggs Discovered 3,500 Meters Beneath an Active Volcano
Beneath an active seafloor volcano off Vancouver Island, researchers have documented a congregation of giant eggs at roughly 3,500 meters, a discovery that reframes how life can flourish under extreme conditions. The eggs belong to the Pacific white skate, an elusive deep‑sea species adapted to cold, crushing pressure and perpetual darkness. What seemed an unlikely nursery is actually a geothermally warmed refuge, where subtle heat helps embryos survive a marathon incubation. The finding links volcanic energy to a quiet engine of biodiversity, turning a hostile landscape into an incubator. A living volcano, a hidden nursery The seamount long assumed dormant now exhales mineral‑rich, shimmering plumes, proof of hydrothermal life at depth. Expedition cameras swept across black basalt and pale bacterial mats, revealing vents that pulse with warmth. That warmth, though modest by human standards, alters the physics of development for cold‑adapted embryos. In a realm where metabolism creeps, even a few degrees can mean faster growth and higher survival. The volcano is not only active; it is ecologically formative, drafting a blueprint for a thriving oasis. Giant eggs and a skate built for the abyss The Pacific white skate, Bathyraja spinosissima, is built for the abyss: broad wings, armored spines, and a life history that trades speed for endurance. Females lay outsized, rectangular “mermaid’s purses,” often 46–50 centimeters long, packed with rich yolk to fuel years of growth. In the frigid deep, embryos can require around four years to hatch, a timeline that magnifies every energetic advantage. The scale is striking—large eggs, large adults, and a textbook case of deep‑sea gigantism. The volcano’s gentle heat may literally shave months or years from the wait. Why heat matters at the bottom of the sea Hydrothermal circulation delivers low‑level warmth without the turbulence that would scatter fragile egg‑cases. Slightly elevated temperatures accelerate enzyme kinetics, nudging development along while keeping embryos within a safe range. Mineral‑laden fluids likely shape local microbiomes, which, in turn, can influence biofilms on egg surfaces. The environment acts like a slow, steady incubator, countering the deep sea’s tyrannies of cold and scarcity. For a species with long maturation and few offspring, every incremental boost compounds across generations. An ecosystem sculpted by fire and water Seafloor volcanoes create steep environmental gradients, stitching together hot vents, cool eddies, and mineral gardens into mosaic habitats. Microbes harvest chemical energy, seeding food webs that support crustaceans, fishes, and skates. Cameras documented egg‑cases nestled among rocky ledges, near communities nourished by vent‑driven chemistry. These islands of productivity behave like deep‑sea oases, sustaining life far beyond the vent orifice’s flickering light. The nursery’s success underscores how geological forces engineer biological opportunity. “Finding a cradle of life tucked beneath a breathing volcano reminds us that the planet’s harshest places can be profoundly generous.” What the discovery could change The nursery reframes conservation priorities in regions where volcanism quietly underwrites reproduction. Protecting hydrothermal corridors could safeguard entire lifecycles, not just charismatic adults spotted during occasional surveys. It also sharpens questions about how climate‑driven shifts in ocean circulation might influence vent activity, temperature fields, and embryo survival. With methodical mapping, time‑series cameras, and environmental DNA, scientists can track whether nurseries remain stable or drift with geologic rhythms. Key implications include: Enhanced understanding of deep‑sea reproduction at hydrothermal sites. New conservation targets centered on geothermal nurseries. Comparative studies with other volcanic regions, from the Galápagos to rift zones. Biotechnological insights from organisms adapted to long, cold development. Better models of how seafloor heat shapes regional biodiversity. Methods behind the revelation Remotely operated vehicles threaded through chimney fields, gathering video, temperatures, and mineral signatures. High‑definition imagery captured the distinctive, horned egg cases, their edges dusted with fine volcanic silt. Geochemical profiles mapped how heat and chemicals disperse, outlining the “thermal lanes” where eggs most cluster. Combined, these datasets reveal a nursery organized by geothermal topography, with egg‑cases concentrated in pockets of gentle, sustained warmth. A fragile boon in a changing ocean Deep‑sea environments feel remote, yet they intersect with global pressures: mining proposals, cable routes, and shifting oxygen levels. The nursery’s resilience hinges on stable heat flow, intact substrates, and minimal disturbance from noise or sediment. Safeguarding such places is not just about protecting novelty; it preserves a slow, ancient strategy that lets large, long‑lived animals endure in the coldest reaches of the Pacific. Where geology and biology meet, the planet’s deep time still writes living stories. This volcano‑warmed nursery adds a vital chapter to that story, revealing how subtle thermal gifts can tip the scales toward life in the abyss. With each dive, researchers trace the contours of an unseen world, where fire feeds water, and water—against all odds—feeds the future.
In wrangling dark matter, some scientists find inspiration in religion
Father Adam Hincks, a Jesuit priest who teaches at the University of Toronto and serves as an adjunct scholar at the Vatican Observatory, believes that for some, contemplating dark matter and dark energy could elevate their minds to God.
Oilers’ Connor McDavid keeps it real on Leon Draisaitl question
Connor McDavid kept his message simple after the Edmonton Oilers secured a 4-2 win over the Anaheim Ducks. Speaking with NHL reporter Gene Principe, the captain addressed life without Leon Draisaitl, who remains sidelined with a lower-body injury. McDavid led…
Phil Weiser wins top spot in Colorado’s Democratic gubernatorial primary at party’s state assembly
Attorney General Phil Weiser’s name will appear first on Colorado’s Democratic gubernatorial primary ballot after his overwhelming win Saturday at the party’s state assembly in Pueblo. Weiser joins U.S. Sen. Michael Bennet in the June 30 primary for the office held by term-limited Gov. Jared Polis. Bennet, who successfully petitioned onto the ballot, didn’t participate […]
William Nylander Coy About Why Maple Leafs Struggled This Season
Kwame Spearman warrants plenty of criticism, not cancellation
All of us are flawed humans, some more so than others. This is the tale of Kwame Spearman who burst onto Denver’s business and political scene a handful of years back. His ride has taken a downhill trajectory. Within the past week, Spearman was shown the door as an undefined executive at the just-opened Denver […]
'Kim's Convenience' review: Back onstage with sitcom warmth intact
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Leeds 0-0 Brentford
Paul: Leeds played as if they are frightened of losing rather than trying to win. Chris: Good point in the end - they are a good side pushing for a European place and have good players. Hopefully in the final run-in we will see more of Daniel James, Wilfried Gnonto and Noah Okafor, especially in the home games, to create more goals and keep us in the Premier League.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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