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James Webb telescope spots 'stingray' galaxy system that could solve the mystery of 'little red dots'

A study of the fascinating galaxy system nicknamed "The Stingray" suggests that mysterious little red dots could be a phase in the evolution of galaxies powered by actively feeding black holes, rather than a distinct class of objects.

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Apr 9 • 12:49 PM EDT • Science • livescience.com
Scientists thought there was a black hole at the centre of our Galaxy. It turns out it may be something even stranger | BBC Sky at Night Magazine

Could Sagittarius A* at the centre of our Milky Way galaxy be not a black hole, but dark matter instead? A new study suggests so.

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Apr 9 • 1:13 AM EDT • Science • skyatnightmagazine.com
Should’ve put a ring on it? Maybe! Marriage is linked to lower risk of cancer

A new study suggests marriage may be linked to a lower risk of cancer, adding to a growing body of research tying it to improved health outcomes.

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Apr 8 • 3:08 PM EDT • Health • cnn.com
Steam client files point to "framerate estimator" feature in the works

JSON text strings suggests performance charts based on "framerates of other Steam users."

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Apr 8 • 11:37 AM EDT • Technology • arstechnica.com
Apple very cautious about iPhone Ultra sales; Samsung wins concession

A new report suggests Apple is being extremely cautious in its expectations of demand for its most expensive ever smartphone,...

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Apr 8 • 8:52 AM EDT • Technology • 9to5mac.com
Liverpool receive sensational Yan Diomande transfer boost

Barcelona drop out of Diomande raceA report from Spain via Sport Witness now suggests that Liverpool will have one less rival bid to worry about this summer. Barcelona did their due diligence on Dioma...

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Apr 8 • 3:05 AM EDT • Sports • sports.yahoo.com
Antibacterial products may contribute to dangerous superbug crisis, study suggests

Antibacterial soaps and cleaning wipes may contribute to antimicrobial resistance, a new study suggests, with experts recommending plain soap and water instead.

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Apr 7 • 10:43 PM EDT • Health • foxnews.com
Is David Jolly riding an off-shore blue wave? His Q1 fundraising suggests momentum is building

Jolly still trails Republican Byron Donalds — by a lot — but he has upped his game since 2 surprise Special Election victories.

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Apr 7 • 4:00 AM EDT • Politics • floridapolitics.com
One Sleep Habit Could Boost Your Heart Health, Study Suggests

A clear message.

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Apr 7 • 12:07 AM EDT • Science • sciencealert.com
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One Sleep Habit Could Boost Your Heart Health, Study Suggests

A clear message.

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Apr 7 • 12:07 AM EDT • Health • sciencealert.com
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Earth's Population Has Surpassed The Planet's Capacity, Study Suggests

"We are pushing the planet harder than it can possibly cope."

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Apr 6 • 11:00 AM EDT • Science • sciencealert.com
Study suggests GLP-1 drugs have mental health perks

The study doesn’t prove causality or determine why GLP-1s could be a boon to people with mental illnesses.

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Apr 5 • 9:42 AM EDT • Health • newsnationnow.com
iPhone Fold rumor suggests it will bring a 3D printed hinge

This is the same tech used on Oppo’s Find N6. A new report from China is confident that the upcoming iPhone Fold will feature a 3D printed hinge to help...

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Apr 5 • 9:02 AM EDT • Technology • gsmarena.com
Nose-Picking May Have a Surprise Link With Alzheimer's, Study in Mice Suggests

Do you really need to pick it?

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Apr 4 • 6:34 PM EDT • Science • sciencealert.com
iPhone 18 Pro Leak: Apple Is Reportedly Killing Its Signature Finish

A new leak suggests that the colors for the iPhone 18 Pro have been finalized — and there’s a surprising omission.

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Apr 4 • 4:00 PM EDT • Technology • forbes.com
Binge drinking just once a month may triple your risk of liver scarring

Many people think that occasional binge drinking is harmless if they otherwise drink in moderation, but new research suggests that assumption may be dangerously wrong. A large U.S. study found that people with metabolic dysfunction–associated steatotic liver disease (MASLD), a condition affecting about one in three adults, face a much higher risk of serious liver scarring if they engage in heavy drinking even just once a month.

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Apr 4 • 8:00 AM EDT • Science • sciencedaily.com
Democrats rebounding without learning necessary lessons

“When we fight, we win!” That, reportedly, was the chant heard over and over again at the Colorado Democratic Assembly a week ago. It suggests that pugilism has been the piece missing from the Democratic toolkit. Perhaps it was just me, but I seem to recall Democrats exhibiting plenty of fight back in 2024. The […]

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Apr 4 • 7:00 AM EDT • Politics • coloradopolitics.com
Young Adults With High Blood Pressure Face Higher Risk of Heart, Kidney Disease

Recent research suggests that adults ages 30 to 40 with high blood pressure may face a higher risk of cardiovascular and kidney disease later in life. These findings highlight the importance of maintaining a healthy blood pressure at a younger age.

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Apr 4 • 3:23 AM EDT • Health • healthline.com
H.H.S. Takes a First Step Toward Restoring Vaccine Advisory Committee

A federal judge last month questioned the legitimacy of the panel and overturned its recent work. A notice suggests that it may be revived on Robert F. Kennedy Jr.’s terms.

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Apr 3 • 3:17 PM EDT • Health • nytimes.com
New research suggests the microplastics health risk may not be as bad as we thought

However, that's definitely not to say microplastics aren't still a big problem, study authors warn.

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Apr 3 • 2:00 PM EDT • Health • fastcompany.com
Experts dispute US account of deadly Lamerd sports hall strike in Iran

Six weapons experts have contested the US claim that video evidence suggests an Iranian missile could have hit the hall.

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Apr 3 • 9:16 AM EDT • Sports • bbc.com
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NHS rehabilitation care staff shortage fails stroke patients, say health leaders

People receive rehab only three to four days a week in hospital – and one to two days once they are discharged, data suggests

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Apr 3 • 12:00 AM EDT • Health • theguardian.com
Scientists say BMI gets it wrong for over one third of adults

A new study suggests that one of the most widely used health metrics, BMI, may be getting it wrong for a large portion of the population. By comparing BMI classifications with precise body fat measurements using advanced DXA scans, researchers found that more than one-third of adults were placed in incorrect weight categories. Many people labeled as overweight or obese did not actually have the corresponding body fat levels, while others were missed entirely.

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Apr 2 • 8:00 PM EDT • Science • sciencedaily.com
Strange “elephant skin” rocks reveal ancient life in the dark ocean

A puzzling wrinkled rock formation in Morocco has led scientists to rethink where ancient microbes could live. Instead of shallow, sunlit waters, these microbes may have thrived deep in the ocean, fueled by chemicals delivered by underwater landslides. The discovery suggests that dark, nutrient-rich environments hosted thriving ecosystems much earlier than expected. It also raises the possibility that many similar fossils have been overlooked or misinterpreted.

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Apr 2 • 8:00 PM EDT • Science • sciencedaily.com
How Many Minutes of Cycling a Week Improve Heart Health?

Evidence suggests even modest riding helps, but there’s a clear target if you want the biggest payoff.

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Apr 2 • 3:32 PM EDT • Health • bicycling.com
Earth’s magnetic field went wild 600 million years ago and scientists finally know why

Hundreds of millions of years ago, Earth’s magnetic field behaved in a way that has long baffled scientists, showing wild and seemingly chaotic shifts unlike anything seen before or since. A new study suggests this chaos may actually hide a deeper pattern: instead of random fluctuations, the magnetic field may have followed a global, organized structure.

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Apr 2 • 8:00 AM EDT • Science • sciencedaily.com
The oldest known dice date back about 12,000 years in North America

A study of ancient artifacts suggests Native American dice games began thousands of years earlier than previously documented.

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Apr 2 • 12:01 AM EDT • Science • sciencenews.org
Neta’s research points to brain-based clues for mental health

In a split second, the brain determines whether an ambiguous situation is good or bad — and those snap judgments can reveal important information about a person. A new article by Husker psychologist Maital Neta suggests that these responses, known as valence bias, could help identify risk factors for depression, anxiety and other stress-related conditions.

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Apr 1 • 8:00 PM EDT • Health • news.unl.edu
Hydrinity Skincare CEO On Why Science Beats Hype

As trends come and go, the brand’s momentum suggests that the skincare industry may be returning to what actually works — thanks to science.

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Apr 1 • 1:12 PM EDT • Science • forbes.com
iPhone 17e vs. iPhone 17 Buyer's Guide: 35+ Differences Compared

The iPhone 17e and iPhone 17 are among the most affordable iPhones in Apple's current lineup, separated by just $200, but the gap between them is more significant than the price difference alone suggests. The $599 iPhone 17e is Apple's budget-first option, built around the efficient C1X modem and a single-camera system.

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Apr 1 • 11:21 AM EDT • Technology • macrumors.com
‘Numerous Systemic Issues’: Letter on Providence Health Insurance Mess Suggests Faulty Planning

In a letter a few weeks ago, the man who manages health care benefits for state employees and their families listed the many ways a major Oregon-based health insurance company was failing them.

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Apr 1 • 10:02 AM EDT • Health • wweek.com
The secret to a great cup of coffee? Scientists think they’ve cracked it

Preparation rather than origin may dictate the taste of the drink, a study suggests, after X-ray scans reveal grind size is key for the perfect espresso

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Apr 1 • 8:25 AM EDT • Science • thetimes.com
Scientists found a baby dinosaur hidden in rock and it is surprisingly cute

Scientists uncovered a rare baby dinosaur in South Korea and named it Doolysaurus after a famous cartoon character. Using cutting-edge CT scans, they discovered hidden bones—including a skull—inside rock much faster than traditional methods. The young dinosaur, possibly fluffy and lamb-like, even had stomach stones that reveal it ate a mix of plants and small animals. The discovery suggests many more dinosaurs may still be hidden in Korea’s rocks.

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Apr 1 • 8:00 AM EDT • Science • sciencedaily.com
Why Health Taxes Alone Won't Fix Malnutrition in Poor Countries

Health taxes on sugar seem to have captured the zeitgeist: Mexico's soda tax, the UK's sugar levy, South Africa's Health Promotion Levy, a sugar tax in the Philippines, and so on. The evidence on these policies suggests real benefits: (1) reduced consumption of sugary drinks, (2) measurable revenue for governments, and, (3) in theory, a nudge toward healthier choices. But the conversation is increasingly moving past sugar with increasing calls for health taxes on so-called ultra-processed foods.

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Apr 1 • 8:00 AM EDT • Health • cgdev.org
Washington doctors are sounding alarm on cannabis health effects, survey shows

More than a decade after recreational cannabis was legalized in Washington, a new survey of health care providers suggests many clinicians are concerned about its effects on patients’ mental health.

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Apr 1 • 7:53 AM EDT • Health • kiro7.com
Extreme wildfires, droughts and storms could happen even under moderate global warming, study finds

New research suggests devastating climate outcomes that are typically associated with extreme global warming could hit even we limit heating to 3.6 F above preindustrial levels.

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Apr 1 • 7:36 AM EDT • Science • livescience.com
New Discovery Challenges Long-Standing Theory On The Formation Of The Earth – Its Building Blocks Came From Right Here

New analysis suggests that Earth’s material originates exclusively from the inner Solar System.

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Mar 31 • 5:44 AM EDT • Science • iflscience.com
Survey: More than half of Washington clinicians cite mental-health risks from cannabis use

More than a decade after Washington legalized recreational cannabis, a new survey suggests many clinicians are increasingly worried about the mental-health risk

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Mar 30 • 4:00 PM EDT • Health • komonews.com
Sports uniform proposal could boost students' physical activity

New research suggests most Australians support a simple change that could significantly boost children's physical activity levels: letting students wear sports uniforms every day. The majority of young ...

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Mar 30 • 12:20 PM EDT • Sports • medicalxpress.com
Recession warning: Walmart's stock suggests more economic pain is coming

The Walmart Recession Signal, a measure of Walmart's stock price relative to luxury stocks, has spiked leading up to the last four US downturns.

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Mar 30 • 10:08 AM EDT • Business • businessinsider.com
Monster black holes are silencing star formation across the universe

A blazing supermassive black hole can influence far more than its own galaxy. Scientists found that quasars emit radiation strong enough to shut down star formation in nearby galaxies millions of light-years away. This could explain why some galaxies near early quasars appear faint or missing. The finding suggests galaxies grow and evolve together, not in isolation.

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Mar 30 • 8:00 AM EDT • Science • sciencedaily.com
A Look At Six Flags Entertainment (FUN) Valuation After Jana Partners Activism And Leadership Shake Up

Six Flags Entertainment (FUN) is back in focus after activist investor Jana Partners publicly urged the company to consider a sale and overhaul its board leadership, prompting a rapid shake up in the chairman role. See our latest analysis for Six Flags Entertainment. The recent governance shake up comes against a mixed backdrop, with a 10.52% 90 day share price return and a 7.17% year to date share price return set against a 1 year total shareholder return decline of 53.46%. This suggests...

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Mar 30 • 7:10 AM EDT • Entertainment • simplywall.st
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Phillies Get Updated Timeline on Potential Zack Wheeler Return

The Philadelphia Phillies didn’t expect Zack Wheeler to be ready for Opening Weekend, and he wasn't, at least at the big league level, but everything about his latest outing suggests his return isn’t far away.

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Mar 29 • 9:38 PM EDT • Sports • sports.yahoo.com
Sleeping 11 minutes longer each night shows surprising health benefit, study finds

New research suggests that improving heart health may be less about drastic lifestyle changes and more about small, consistent daily habits.

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Mar 29 • 9:19 PM EDT • Health • fox13news.com
Sleeping 11 minutes longer each night shows surprising health benefit, study finds

New research suggests that improving heart health may be less about drastic lifestyle changes and more about small, consistent daily habits.

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Mar 29 • 9:19 PM EDT • Health • ktvu.com
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People Love Saying Government Should Be Run Like A Business, Says Economist Justin Wolfers, Just Not Like 'The Sopranos'

A growing body of data suggests something is deeply off inside the federal workforce. “Lots of people say we ought to run the government like a business,” University of Michigan economist Justin Wolfe...

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Mar 29 • 12:31 PM EDT • Business • yahoo.com
Hingham Schools Eye Business Curriculum Expansion as Class Size Concerns Mount

HINGHAM - March 23, 2026 - The Hingham School Committee moved to modernize its high school offerings Monday night, reviewing a comprehensive plan to expand the “small but mighty” Business Department while simultaneously grappling with data that places Hingham as an outlier in elementary class sizes. Director of Social Studies Andy Hoey presented a two-year program review that highlighted the department’s success in community partnerships but warned that high student demand is testing current staffing limits. Meanwhile, committee Chair Jen Benham presented independent research showing Hingham is the only benchmark district with second-grade classes hitting a 25-student cap, sparking a directive for the Policy Subcommittee to review class-size standards. Editors note: South Shore News is going paid in April, subscribe now to make sure you don’t miss a story. Reach out for group or organizational pricing. Subscribe The Full Story The meeting opened with a look into the future of Hingham High School’s (HHS) curriculum. Andy Hoey, who oversees the Business Department, presented the first formal program review for the department since 2009. [15:09] Hoey characterized the department as a vital elective hub that currently serves between 14% and 27% of the HHS student body in any given year. [31:31] “We are very proud of our business department here at Hingham High School... while we’re very proud of it, we are always striving to make improvements and enhancements.” [15:55] — Andy Hoey, Director of Social Studies A key highlight of the presentation was the announcement of a new AP Business with Personal Finance course launching next year, pending enrollment. [20:08] The review team found that while the program is “well-aligned” to national standards, it remains a high-school-only offering. Hoey outlined an action plan to explore “vertical articulation,” potentially introducing business or financial literacy units at the middle school level to fill a “gap” identified between fifth and eighth grade. [41:48] However, the department faces “smoke and mirrors” regarding student GPA, according to Hoey. Currently, most business courses are “unleveled” and do not count toward a student’s GPA, which survey data suggests may deter some students from enrolling. [28:15] The committee discussed the possibility of offering Honors or College Prep (CP) credit for advanced courses, such as investing or marketing, to better reflect their academic rigor. [38:27] The discussion took a sharp turn toward elementary education during an enrollment update. Superintendent Dr. Katie Roberts noted a net gain of four students mid-year, but it was Jen Benham’s “rabbit hole” data analysis that caught the committee’s attention. [50:35] Benham researched 13 benchmark towns—representing 34 elementary schools—and found that Hingham was the only district with a second-grade section reaching 25 students this year. [51:36] Benham’s findings suggested that while many districts lack formal class-size policies, Hingham’s current cap of 25 for second grade may be too high. “I think if we could at least have 23 at a cap for grade two,” Benham suggested, noting the importance of that grade level for literacy development. [53:09], [54:55] Dr. Roberts cautioned that smaller classes require more staff, which is a significant hurdle following a budget season where nine general education positions were cut across the district. [55:56] The committee also finalized the 2025 Town Report, which was updated to be more “student-centered” and highlight staff early in the document. [11:12] Additionally, a series of food service policies were approved to align with Massachusetts’ universal free school meal mandate, including new protocols for meal modifications due to allergies or religious needs. [59:23] Share Why It Matters The meeting underscored a tension between Hingham’s desire to offer elite, specialized programming and the foundational pressure of class sizes. The expansion of the Business Department—including potential Microsoft certifications and AP courses—aims to prepare students for a “real world” where credit scores and financial literacy are paramount. [46:20] However, the revelation that Hingham’s second-grade classes are larger than those in all neighboring benchmark towns suggests a potential strain on early education that could impact long-term student performance if not addressed by the Policy Subcommittee. Official Minutes & Data Key Motions & Votes Motion: To approve the Hingham Public Schools 2025 Town Report. [13:16] Vote: Unanimous (7-0) ([01:13:28]) Motion: To approve the Memorandum of Agreement (MOA) for summer counselor work regarding course placement. [57:33] Vote: Unanimous (7-0) ([57:50]) Motion: To approve Policy EFBA (School Food and Nutrition/Meal Modifications). [01:00:32] Vote: Unanimous (7-0) ([01:00:44]) Motion: To approve Policy EFC (Universal Free School Meals). [01:00:54] Vote: Unanimous (7-0) ([01:01:07]) Public Comment No members of the public spoke during the meeting or via the remote link. [01:02:30] What’s Next The Policy Subcommittee will take up the review of elementary class-size caps over the next year to determine if the Grade 2 limit should be lowered from 25 to 23. [52:18] The Business Department will monitor enrollment for the new AP Business course and continue exploring dual-enrollment partnerships with Quincy College. [38:13] Source Video: Harbor Media South Shore News is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe

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Mar 29 • 7:03 AM EDT • Business • southshore.news
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Study Links High Antioxidant Intake To Changes in Offspring Development

By HealthDay Staff HealthDay ReporterSUNDAY, March 29, 2026 (HealthDay News) — Antioxidants are often seen as a good, simple way to boost health, but taking too many may come with some risks, new research suggests. A study from Texas A&M University found that high doses of certain antioxidants may ...

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Mar 29 • 7:00 AM EDT • Health • usnews.com
Elon Musk Joins in Phone Call Between Donald Trump and Narendra Modi

Mr. Musk’s participation was notable because it is rare for a private citizen to be on a call between heads of state. It also suggests that Mr. Musk is back on better terms with the president.

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Mar 27 • 3:02 PM EDT • Politics • nytimes.com
Scientists stunned as Mars dust storms blast water into space

Mars may look like a frozen desert today, but new evidence suggests its watery past didn’t simply fade away quietly—it may have been blasted into space by powerful dust storms. Scientists have discovered that even relatively small, localized storms can hurl water vapor high into the atmosphere, where it breaks apart and escapes.

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Mar 26 • 8:00 PM EDT • Science • sciencedaily.com
Can pesticide exposure before pregnancy affect babies’ health?

A new study suggests a correlation between certain chemical compounds and lower newborn health scores.

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Mar 26 • 7:15 PM EDT • Health • universityofcalifornia.edu
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Sperm get lost in space, Australian research into microgravity impacts suggests

Study into how fertilisation could work in space finds sperm may get disorientated when trying to find an egg

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Mar 26 • 12:00 PM EDT • Science • theguardian.com
Scientists Say This Hellish “Day-Night” Planet May Support Life

A new study suggests that even the most extreme exoplanets might not be entirely inhospitable.

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Mar 25 • 5:14 PM EDT • Science • scitechdaily.com
Humans Had Dogs Before They Had Farming, Ancient DNA Confirms

New research pushes the first genetic evidence of dogs back by 5,000 years and suggests that hunter-gatherer groups may have acquired dogs from one another.

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Mar 25 • 12:00 PM EDT • Science • nytimes.com
Want To Protect Your Brain? Science Says Exercise

By HealthDay Staff HealthDay ReporterWEDNESDAY, March 25, 2026 (HealthDay News) — Lunges and squats may do more for the brain than previously thought, including helping protect it from damage tied to aging and dementia, a new study suggests. In research published this month in the journal Cell,

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Mar 25 • 9:40 AM EDT • Science • usnews.com
This Unique Diet Could Slow Your Brain Aging by Over 2 Years, Study Suggests

Food for thought.

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Mar 24 • 11:27 PM EDT • Science • sciencealert.com
Talking about politics at work may support employee well-being, study finds

In an era of nonstop headlines and growing political division, many workplaces still follow a familiar rule of thumb: Don't talk politics at work. New research from Washington State University suggests ...

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Mar 24 • 8:40 PM EDT • Politics • phys.org
WATCH: 'We negotiate with bombs,' Hegseth says of U.S. air campaign in Iran

President Donald Trump has listed five objectives that the U.S. wants to achieve before ending its war with Iran. Now, as he suggests the U.S. may soon be “winding down” the operation after three and a half weeks, some of his key aims remain undefined or unfulfilled.

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Mar 24 • 5:57 PM EDT • Politics • pbs.org
Drought could fuel the rise of antibiotic-resistant superbugs as climate change worsens, new research suggests

A warming world may see more antibiotic-resistant bacteria, according to new research that shows a link between aridity and antibiotic resistance today.

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Mar 24 • 5:02 PM EDT • Science • livescience.com
Marathon has sold 1.2M copies across Steam, PS5, and Xbox

Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]

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Mar 24 • 2:06 PM EDT • Technology • alineaanalytics.substack.com
A rare active volcano on Mars may be causing the whole planet to spin faster

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Mar 24 • 11:58 AM EDT • Science • livescience.com
ICE officers at airports a ‘test run’ for midterms, Steve Bannon suggests

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Mar 24 • 6:34 AM EDT • Politics • theguardian.com
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Mar 24 • 6:00 AM EDT • Science • nytimes.com
We’ve Been Underestimating Flying Foxes

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Mar 24 • 6:00 AM EDT • Science • nytimes.com
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Mar 23 • 7:40 PM EDT • Health • medicalxpress.com
Can pesticide exposure before pregnancy affect babies’ health?

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Mar 23 • 7:33 PM EDT • Health • newsroom.ucla.edu
Dems hope for long-shot upset in SD 14 Special Election between Josie Tomkow, Brian Nathan

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Mar 23 • 7:30 PM EDT • Politics • floridapolitics.com
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Mar 23 • 12:20 PM EDT • Politics • floridapolitics.com
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Mar 23 • 3:00 AM EDT • Health • medicalxpress.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Cuba Says Its Military Is Prepared as Trump’s Threats Multiply

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Mar 22 • 9:00 AM EDT • Politics • bloomberg.com
Scientists twisted a mysterious superconductor and got a shocking result

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Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
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Mar 22 • 12:00 AM EDT • Technology • nintendoeverything.com
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Mar 21 • 8:23 PM EDT • Science • scitechdaily.com
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Mar 21 • 2:00 AM EDT • Health • euronews.com
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Mar 20 • 8:00 PM EDT • Science • sciencedaily.com
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Mar 20 • 2:40 PM EDT • Politics • nytimes.com
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NFL Writer suggests potential Travis Kelce successor for the Chiefs

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Mar 19 • 7:00 AM EDT • Sports • sports.yahoo.com
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This overlooked organ may be more vital for longevity than scientists realized

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Mar 18 • 12:00 PM EDT • Science • scientificamerican.com
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Mar 18 • 9:05 AM EDT • Health • usnews.com
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Mar 17 • 7:00 AM EDT • Politics • cnn.com
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Mar 15 • 8:00 AM EDT • Science • sciencedaily.com
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Mar 15 • 6:00 AM EDT • Health • washingtonpost.com
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Mar 14 • 8:00 PM EDT • Science • sciencedaily.com
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Mar 13 • 6:17 PM EDT • Science • popularmechanics.com
Judge quashes Justice Department subpoena of Federal Reserve

Judge James Boasberg said that a "mountain of evidence suggests" that the purpose of the subpoenas was simply to pressure the Fed to cut its key interest rate

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Mar 13 • 3:41 PM EDT • Politics • spectrumlocalnews.com
FDA move on flavored vapes rattles public health experts

New FDA guidance suggests mint, coffee, and spice vape flavors could be authorized, raising debate over toxic additives and youth vaping risks.

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Mar 13 • 4:30 AM EDT • Health • statnews.com
In anti-Muslim post, Tuberville suggests New York’s Mamdani is ‘the enemy’

The Alabama senator, who is running for governor of his state, has previously called for the mass expulsion of Muslims from the United States.

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Mar 12 • 1:58 PM EDT • Politics • washingtonpost.com
A large fossil leg bone hints at T. rex’s origins, but scientists disagree

A new analysis of a large fossil shinbone suggests T. rex ancestors came from North America instead of Asia. Not everyone agrees.

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Mar 12 • 12:00 PM EDT • Science • sciencenews.org