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Benjamin Logan students shine at Regional Science Day competition
Benjamin Logan students had a strong showing at the Ohio Academy of Science Regional Science Day at Ohio Northern University. Competing against top students from […]
AI-generated attack ads are already slopping up Mass. races
AI attack ads are already showing up in Massachusetts races — and the 2026 cycle is just getting started.
Staff revolts, secret meetings: Inside the tense fight between Mike Pence and the Heritage Foundation
Mike Pence used to dream of following two successful Donald Trump terms with his own turn in the White House.
Palm Beach County high school sports weekly schedule for March 23-28
High school sports are back in full swing in Palm Beach County. See the full schedule for baseball, softball, lacrosse and more.
Small swings, high drama: why UK polls are less volatile than they seem
In what is beginning to look like a fragmented five-party system, small swings carry outsized political consequences
Historical Wigan cotton mill to reopen as entertainment venue.
Factory Floor is set to open in Wigan's Grade II-listed Eckersley Mill following a £3m revamp.
Funding for populist-right ‘media-political complex’ exceeded £170m in five years, research finds
Handful of billionaires gave huge sums in particular to media organisations that boosted rightwing politicians, says Liam Byrne MP
The DLSS 5 Backlash Is Still Swirling
Almost a week on, the controversy and backlash over NVIDIA’s DLSS 5 announcement are still swirling, following some mixed messaging from the company about how the tech works. A reveal trailer on Tuesday showcased multiple games like “Resident Evil Requiem,” “Starfield”, and “Hogwarts Legacy” using the new technology, which goes beyond simple upscaling and leads […]
Longhorns secure major upgrade following NCAA decision on eligibility waiver
Improving the offensive line has been a major focus for Texas this offseason, and the Longhorns got a big piece of that puzzle locked in on Wednesday following weeks of eligibility uncertainty.
Arizona Diamondbacks Spring Training Gameday Thread, #30 @ Padres
Roster moves The Arizona Diamondbacks made the following roster moves and have 33 players in camp. Optioned to Triple-A Reno: Reassigned to Minor League camp: The first of these is a bit of a surprise. Only yesterday, I was noting how Abner seemed to have the inside track for left-handers job, after the recent meltdowns […]
Chelan Co. Sheriff’s Office secures nearly $55k in funding for behavioral health unit
The Chelan County Sheriff’s Office has secured nearly $55,000 in outside grant funding to support and expand its behavioral health crisis response program, allowing the agency to add training, equipment and other resources without using county funds.
This Couple Turned A Facebook Marketplace Side Hustle Into A Seven-Figure Business
When Harrison Gordon and Paige Sandher couldn't find a modular custom sofa that was also affordable, they designed their own. They built a fast-growing business around their idea.
Slovenia liberals take narrow election lead over conservatives: exit poll
Exits polls suggest Prime Minister Robert Golob has blocked a fourth term for right-winger Janez Janša
Federal union says 'untrained' ICE agents shouldn't replace TSA
President Donald Trump said he would tap ICE agents to run security at US airports as unpaid TSA officers stop showing up to work.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Are spring temperature swings hurting your health? Yes, here's how
Weather swings affect your physical health in a variety of ways.
Immigration crackdown impact on local Latino-owned businesses
Latino business owners told WRAL News that fear and uncertainty following a nationwide crackdown in immigration enforcement are keeping some families out of public spaces, leaving small businesses struggling to survive. This story was written by Oriana Torre, a senior graduating journalism student at the University of Florida, participating in the CBC-UNC News Media Multiplatform Fellowship.
Why mosquitoes always find you and how they decide to attack
Scientists have finally cracked how mosquitoes decide where to fly—and it’s not by following each other. Instead, each insect independently reacts to visual cues and carbon dioxide, zeroing in on humans when both signals align. Dark colors and CO2 together create the strongest attraction, triggering swarming and biting behavior. This insight could reshape how we design traps and prevent mosquito-borne diseases.
Pompey's hopes of staying up now unsure
BBC Radio Solent commentator Andrew Moon gives his thoughts following Portsmouth's 6-1 defeat at Queens Park Rangers in the Championship.
“Let’s get ourselves back to Fort Worth, but take care of business at hand,” LSU after loss in Tulsa
LSU Gymnastics’ Sophomore Kailin Chio and Head Coach Jay Clark spoke to the media following a third place finish in the 2026 SEC tournament in Tulsa, Oklahoma. Tiger fans came into the BOK Center hopeful for a victory due to having a podium setup, which LSU seems to have thrived on in the past. Which...
Colorado lawmakers can pass “Alyssa’s Act” to help coaches and parents monitor mental health (Opinion)
In 2019, we lost Alyssa after she struggled with her mental health following a series of concussions. We later learned that concussions can be linked to serious mental health challenges and an increase in suicide, especially in young people.
Inflatable homes on the Moon? Scientists reveal how humans could live there sooner than expected - Futura-Sciences
How could humans live on the Moon? Although the Artemis program has taken a more cautious approach following recent delays, the goal remains the same: send astronauts back to the lunar surface. Doing so will require systems that allow crews to stay there for several days, or even several weeks....
The Antidote to Our Growing Crises Must Transcend Politics
Each day, the challenges in our nation pile up. In just recent weeks, there has been the ongoing war in Iran and the Middle East, and ongoing debates about the growing negative impact of the Internet, looming AI challenges, and the Epstein files. The anticipation of divisive, even ugly, midterm elec...
Election in Slovenia Will Test Europe’s Political Mood
The center-left government is being challenged by a right-wing populist accused of launching a smear campaign in the final days of a close race.
Another Illinois basketball player enters legendary status in NCAA tournament
The Illinois basketball team has had some incredible performances this season, and one player just put up an amazing Round of 32 showing against VCU.
More school-based health clinics fill growing needs
An increase in school-based health clinics is sweeping the states of Ohio and Michigan, following research that grounds positive health outcomes for ...
‘They want to colonise us’: Brazil’s Lula warns of foreign interference
The left-wing Brazilian president is critical of US actions throughout Latin America, though he does not name Trump.
Uber's Advertising Business May Be Bigger Than Investors Think
Uber is best known for moving people and delivering food. However, something small but potentially profitable is growing at the company.
NCDHHS launches new program looking to expand number of mental health providers in state
In North Carolina, the demand for social workers in the state is growing as substance use and mental health service needs increase. The North Carolina Department of Health and Human Services launched the Public Service Leadership Program, a collaboration between the NCDHHS and 25 higher education institutions in the Social Work Coalition on NC Work Development, to help with that demand.Alongside the announcement of the new program on March 2, the NCDHHS released its first “State of North Carolina’s Mental Health and Substance Use Services Workforce Report” supported by UNC’s Behavior Health Workforce Research Center and Sheps Health Workforce NC.
Franklin Templeton CEO Jenny Johnson on the values needed to keep a billion-dollar business in the family
Jenny Johnson is CEO of $12 billion family-run asset management business Franklin Templeton, which oversees nearly $2 trillion in assets. Growing the company and succeeding in the role took everyone in the family, including herself, putting their egos aside.
Big Money Flows Into State Attorney General Races as Legal Battles Shape American Politics
With control of Congress on the ballot in November, state attorney general races can get lost in the shuffle. But just outside the election spotlight, there are partisan groups, corporate interests and advocacy networks revving up campaigns for offices that are playing a growing role in American ...
NASA’s Hubble accidentally caught a comet breaking apart in real time
In an incredibly lucky cosmic accident, NASA’s Hubble Space Telescope captured a comet breaking apart in real time—something astronomers have long tried and failed to observe. The comet, C/2025 K1 (ATLAS), wasn’t even the original target, but when researchers pivoted to it, they unknowingly caught it mid-disintegration into multiple pieces.
Health system operating in full emergency mode following Iranian missile impacts in south
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The end of the ISS is looming, and the US could have a big problem
As the US sets its sights on establishing a permanent base on the moon, its foothold in an area of space much closer to home is growing more uncertain.
Woman, from Large Filipino Family That Loves Food, Thought Health Issues Were Caused by Her Diet. They Weren't (Exclusive)
A woman thought her health issues were caused by her diet, growing up in 'a big Filipino American family, where food is often the center of all gatherings.' However, Jamie Nangpi Harris' ailments were tied to Crohn's disease, a chronic, autoimmune-driven inflammatory bowel disease (IBD) that affects the digestive tract, she tells PEOPLE exclusively.
Combating youth suicide tilts increasingly toward early intervention
A suicidal child or teenager may never talk of taking their life. Parents, peers and teachers might not even know they’re living with mental illness. Despite younger generations showing greater openness to discussing mental health struggles, fears of punishment or social exclusion remain, experts say. Even at medical appointments, minors
Your 2026 NCAA Basketball Tournament Viewing Guide: March 21, 2026
Bummed about only one men’s tournament game at a time for 6 hours today? THAT’S WHAT THE WOMEN’S TOURNAMENT IS FOR!
Nebraska lands the commitment of 3-star athlete Kaden Howard
The feel-good momentum surrounding the Nebraska athletic department continues to build following the men’s basketball team’s first-round NCAA Tournament victory—and it’s now carrying over onto the recruiting trail. The Cornhuskers have secured a commitment from 3-star athlete Kaden Howard, a 5-foot-10, 160-pound playmaker out of Miami, Florida. Howard picked Nebraska over Louisville, West Virginia and […]
Norfolk racing driver Will Macintrye feels in 'limbo' over health
Will Macintyre says following chemotherapy treatment his condition got worse.
Israel strikes Hezbollah's civilian as well as military wings in an attempt to crush the group
An Israeli strike has hit a Hezbollah-run health center in southern Lebanon and killed 12 medical workers, as Israel widens its campaign beyond fighters
One arrested, another cited in shoplifting incident at business on East Avenue in Chico
CHICO, Calif. - A Paradise man was arrested and a Forbestown woman was cited by Chico Police in connection to a shoplifting incident at a business in Chico.The Chico Police Department says that at around 12:30 p.m. on Wednesday, March 18, a loss prevention employee observed two suspects stealing several items from a retail business on the 700 block of East Avenue in Chico.Upon exiting the building, the two suspects, a man and a woman, were contacted by the loss prevention employee regarding the stolen items. The employee was able to persuade both suspects to return to the store and hand over the items they had stolen.Authorities say the business expressed their desire to press charges against the suspects and contacted Chico Police to report the crime.Officers reviewed video surveillance that confirmed the employee's account of what happened. Officers then made arraignment for both suspects to turn themselves in the following day.When the suspects, identified as 51-year-old Jamie Leal of Forbestown and 62-year-old Melvin Royal of Paradise, arrived the next day to turn themselves in, authorities say both admitted to their involvement in the incident and elected to write handwritten apology letters to the business.Leal was cited by Chico Police on a misdemeanor charge of shoplifting.Royal was taken into custody and transported to the Butte County Jail, where he was booked on the following charges:Shoplifting with 2+ priors (felony)Shoplifting (misdemeanor) googletag.cmd.push(function() { googletag.display('ad-1514992'); });
Exclusive | Growing Frustration With Chuck Schumer Spurs Talk of Replacing Him
Some Democrats on Capitol Hill are discussing how to get New York’s senior senator to step aside as minority leader amid concerns about his negotiating style and midterms strategy.
Downtown Chico business owner voices concerns over street closures for events
A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO { "@context": "https://schema.org", "@type": "VideoObject", "name": "Downtown Road Closure Dilemma", "description": "A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO", "thumbnailUrl": "https://bloximages.newyork1.vip.townnews.com/actionnewsnow.com/content/tncms/assets/v3/editorial/c/47/c47e26d6-03c3-5f35-bf49-37925ab603d7/69bdedc4eb57d.image.jpg", "uploadDate": "2026-03-20T17:45:00-07:00", "contentUrl": "https://cdn.field59.com/KHSL/1774053903-6e1ef36dd09fbebf020833aee86b60da3b3cca3f_fl9-720p.mp4" } CHICO, Calif. - A downtown Chico business owner is voicing concerns about the impact of street closures for events on local shops. Leann Powell, owner of The Peddler’s Closet, expressed concern about events closing down streets downtown and bringing in food trucks and other shops’ products that directly compete with the brick-and-mortar stores in downtown Chico.Powell said an upcoming event held on a Saturday has brought up concerns for her and other business owners downtown, due to it being a busy day for businesses. "We're already struggling, and then to bring in more businesses on top of our businesses and shut our streets down is absolutely devastating," said Powell.Powell noted a decline in business during events like the Thursday Night Market, where street closures allow outside vendors to set up shop. She shared that while organizers for these types of events often offer booths to local businesses, it does not alleviate the burden."I don't really feel like that's a solution because you're bringing in other businesses, you're shutting the streets down. Yes, we can go down and set up a space, but then you've gotta pay somebody to run that space, plus run your own business for the day, and it's really not, it's really not helpful for us," said Powell.Applying for a street closure permit in Chico involves approval from the Public Works Department, the Chief of Police, and the Fire Chief. Permits can be denied only under a handful of circumstances, such as interference with first responders, previously scheduled construction, or existing permits for the same space.Mayor Kasey Reynolds addressed the issue, saying the city council has tasked staff with reviewing the municipal code for street closure permits with the goal of finding ways to minimize negative impacts on local businesses during events.Reynolds mentioned that any recommended changes might require further direction from the city council, depending on the extent of any changes recommended. googletag.cmd.push(function() { googletag.display('ad-1514992'); });
Scientists turn probiotic bacteria into tumor-hunting cancer killers
Scientists have engineered probiotic bacteria to act as tumor-seeking drug factories. In mice, these bacteria infiltrated tumors and produced a cancer-fighting drug right where it was needed. This targeted approach could make treatments more effective and reduce side effects. More research is needed before it can be tested in people.
New Generations Urgent Care opens in Redding to meet growing health care needs
A new urgent care clinic, Generations Urgent Care, has opened in Redding, aiming to expand access to medical services in the Northstate.Co-owners Dr. Eryn Simmo
Nvidia Confirms DLSS 5 Is Re-Drawing Games, and That Sucks
Nvidia has confirmed that the new DLSS 5 algorithm is redrawing games based on a 2D image input and motion data. That's not great!
Nuclear reactor developer X‑energy files for US IPO
X-energy has filed for an initial public offering in the United States, it said on Friday, as the reactor developer aims to tap growing investor enthusiasm for nuclear power.
Eviction reform, Aquarion, towing laws: CT politics news
Plus: DeLauro wants to fund DHS but not ICE, and bills increasing the ECS formula and offering tax credits for paid internships advance.
Hubert Davis buyout: What it would cost UNC to move on from coach after first-round NCAA Tournament exit
The Tar Heels' second straight first-round NCAA Tournament exit adds to growing questions about the program's direction
Opinion | Why the Trump FCC Cares About Your Sports Viewing
Its irrepressible chairman never runs out of ways to advance the president’s political interests.
Chicago's teetering debt is stark warning left-wing mayor is fueling 'pay later' doom cycle: expert
Expert Austin Berg warns Chicago's "pay later" debt culture under Mayor Brandon Johnson is alarming markets with a $1 billion budget gap and risky bond deals.
More Subnautica 2 legal trouble brewing amid claims Krafton "intentionally leaked" May release without consulting reinstated CEO
Lawyers for Subnautica 2 studio's newly reinstated CEO are reportedly pushing for Krafton to be found in contempt of court after it "leaked" a May release.
NVIDIA’s DLSS 5 Reveal Was a Mistake, Needs to Go Back to the Drawing Board, Says Eternal Darkness Dev Denis Dyack
Eternal Darkness creator Denis Dyack calls NVIDIA's DLSS 5 reveal a mistake and adds that it needs to go back to the drawing board.
New controls can stretch, blur and even reverse quantum time flow
In new research published in Physical Review X, scientists have designed quantum control protocols that generate processes more consistent with time flowing backward than forward. The protocols—techniques ...
Crimson Desert developers "doing our utmost" to respond to its various launch issues, as game still passes huge one-day sales milestone
Crimson Desert - the ambitious single player RPG spin-off from Pearl Abyss - has sold through 2m copies following its release.
Chadwick Boseman's widow shares details of his cancer journey and death: 'A betrayal of faith'
'Black Panther' star Chadwick Boseman died in August 2020 following a private battle with colon cancer. His widow is sharing new details of the actor's cancer journey and death.
Apple Announces New Mac Sales Record Following MacBook Neo Launch
Apple's CEO Tim Cook today said the Mac just had its "best launch week ever for first-time Mac customers," which suggests that the new MacBook Neo has been a hit with customers buying their first laptops or switching from Windows. Apple released the MacBook Neo last Wednesday, March 11. In the U.S., pricing starts at just $599 for the general public and an even lower $499 for college students.
The R.I.-based pharmacy giant also owns health insurer Aetna and pharmacy benefit manager Caremark, allowing it to control how medications are priced, prescribed, and dispensed
CVS owns health insurer Aetna and pharmacy benefit manager Caremark, allowing it to control how medications are priced, prescribed, and dispensed.
Men are losing a key chromosome with age and it may be deadly
Aging men often lose the Y chromosome in a growing number of their cells—and it may be far more dangerous than once believed. This loss has been linked to heart disease, cancer, Alzheimer’s, and shorter lifespans. Researchers suspect Y-less cells may grow faster and disrupt normal body functions. What seemed like a minor genetic quirk could actually be a major driver of age-related disease.
SAP CEO Says Defense Industry Sales Are Fastest Growing Business
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“Loyal Slaves” and Campfire Entertainment in Frank Vizetelly’s Confederate Camp
Frank Vizetelly’s illustration titled “Night Amusements in the Confederate Camp” appeared in the Illustrated London News on January 10, 1863. It was one among a number of wartime scenes that Vizetelly captured for the newspaper. Subscribe Following the war, the illustration appeared in a number of books, including John O. Casler’s Four Years in the Stonewall Brigade (1893) and Campfires of the Confederacy (1898) by Ben La Bree. The scene depicts a Confederate camp at night with an enslaved man, most likely a camp servant, performing a dance around a fire with the music provided by a soldier playing a banjo. Another enslaved man looks on at the right. Vizetelly likely witnessed the scene—one that would have been common throughout the war. It’s a wonderful example of the way in which Confederates—slaveowners and nonslaveowners alike—experienced the presence of slave labor in the army. Vizetelly was deeply sympathetic to the Confederate cause. His depiction of the enslaved man as more than happy to entertain the very people who were fighting to keep him enslaved was precisely the kind of image designed to reassure a British audience that slavery was benign, and by implication, that Britain need not feel morally troubled about recognizing or supporting the Confederacy. Share Just as importantly, the sight of a dancing slave reassured Confederates themselves that the institution of slavery remained secure even after President Lincoln signed the Emancipation Proclamation. I’ve come across this illustration many times before and I plan on using it in my next book project on the role of enslaved labor in the Confederate army during the Gettysburg Campaign, but this is not the reason I am sharing it with you today. It has to do with where I recently found it, which came as a complete surprise and is incredibly revealing. Let’s take a look.
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Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
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