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Small Business Promotion Week: Hey Honey Marketplace
Jennifer Reeves, nurse turned boutique owner, came up with the idea for Hey Honey Marketplace, a boutique on Abram Street that aims to not just be a store but a community gathering place for women.
Inaugural Health Care by Food research award honors excellence in food is medicine science
DALLAS, March 23, 2026 — At a time when American dietary patterns are facing renewed attention, the American Heart Association has announced its inaugural Health Care by Food™ Most Impactful Food Is Medicine Research Award, honoring the year’s most...
Funny business: Humor scholars on whether jokes help or hurt at work
Leeds researchers Tony Kong and Peter McGraw agree humor has real workplace benefits, but pulling it off can be tricky.
UNH Paul College Top Public Business School in New England for Academic Experience and Career Outcomes
UNH’s Paul College ranks No. 63 nationally in 2026 Poets&Quants rankings, leading New England public schools in academic experience and career outcomes.
Inaugural Health Care by Food research award honors excellence in food is medicine science
DALLAS, March 23, 2026 — At a time when American dietary patterns are facing renewed attention, the American Heart Association has announced its inaugural Health Care by Food™ Most Impactful Food Is Medicine Research Award, honoring the year’s most...
Free sports physicals return for public school students in Flagler and Volusia counties
Thousands of middle and high school students in public schools across Volusia and Flagler counties can receive free sports physicals this spring as AdventHealth helps young athletes prepare safely for the upcoming season.
PATLABOR the Case Files announced for PS5, PC
Publisher Good Smile Company and developer Chime Corporation have announced 3D action game PATLABOR the Case Files
Samsung adds native AirDrop support to Galaxy S26 devices
Share files with Apple-using friends
Ambani's Reliance Jio: businesses and investors of the IPO-bound firm
Indian billionaire Mukesh Ambani's Reliance Jio Platforms is gearing up to file papers seeking regulatory approvals for a Mumbai listing, in what is likely to be the biggest-ever stock offering in the country.
Turning coal to medicines: Chinese scientists bring a 160-year-old dream to life
Study cracks a puzzle that has baffled scientists and will reshape modern medicine production as the world reels from a global oil shortage.
A DNA test ruled him out. He was convicted of murder anyway.
Forensics has its share of high-profile problems. There’s phony “junk science,” like bogus bite-mark and blood spatter analyses that have sent innocent people to jail. And there’s the steady drumbeat of lab scandals, where analysts make up results. But there’s a subtler and more pervasive problem at work in many cases: lab analysts and lawyers who take perfectly legitimate science and twist it. Globe Opinion is exploring these distortions with a series we’re calling “Twisted Science.” And there may be no better place to start than with the case of Terrel Barros.
Eye of Terror – New rules for Defilers, Mutilators, and Kravek Morne
See the new datasheets now.
Art and science collide in alumna’s artwork
Juliet Fiss, an RIT imaging science alumna, uses algorithms and formulas to create artwork, including a piece at RIT’s Carlson Center.
‘We’ve got some unfinished business’: Corey Gipson reflects on historic Austin Peay season
Austin Peay men's basketball head coach Corey Gipson recently reflected on his 2025-26 season and revealed what makes Clarksville special.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Drew Barrymore says talk show audience member once criticized her dating profile
Drew Barrymore is remembering the time an audience member on her talk show gave his honest thoughts about her dating profile: 'I would probably run away.'
'Completely lawless': Why this congresswoman wants Pam Bondi impeached
From the Epstein files to the integrity of prosecutions, Democratic Congresswoman Summer Lee says Attorney General Pam Bondi is damaging the DOJ.
Flexitarian and the MIND included in top diets for a healthy brain, according to U.S. News
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The Antidote to Our Growing Crises Must Transcend Politics
Each day, the challenges in our nation pile up. In just recent weeks, there has been the ongoing war in Iran and the Middle East, and ongoing debates about the growing negative impact of the Internet, looming AI challenges, and the Epstein files. The anticipation of divisive, even ugly, midterm elec...
Bridging medical realities in the study of technology and health
Anthropologist and MIT Associate Professor Amy Moran-Thomas studies medical technologies and how they fail to reach some communities. “What anthropology has to offer the world, and other knowledge systems, is the insights of people that might be missing from many accounts,” she says.
Healthy Kids Day collaboration with PTO Science Night, April 17
FROM FACEBOOK__Get ready for an action-packed evening! This year, the Bluffton YMCA Healthy Kids Day is joining forces with the Bluffton Schools PTO Science Night for one massive community event!
Dana Walden unveils leaders of expanded Disney Entertainment
Dana Walden, the incoming President and Chief Creative Officer of The Walt Disney Company, has unveiled the new leadership structure for Disney Entertainment, bringing together the company’s streaming, film, and television businesses along with its games and digital entertainment division.
Politics Unplugged (Full Episode) March 22, 2026
This week on Politics Unplugged, Progressive activist Kai Newkirk explains why he is running to unseat Democratic incumbent Greg Stanton in the congressional race in CD4. Then, consultants Marcus Dell’Artino and Matt Grodsky discuss the fallout from the Cesar Chavez allegations and the political importance of high gas prices.
Robert Mueller, former special counsel who led Trump-Russia probe, dies
A decorated Marine and longtime law enforcement leader, Mueller served as FBI director before taking on the high-profile investigation in 2017.
Flood-prone Kīhei Crossroads for sale as its popular businesses remain closed from latest storm
In June of 2025, the popular strip shopping center near the Kīhei Canoe Club and the surrounding vacant land went on the market for $15.85 million.
The reality of death and the Trinitarian “science” of salvation
Readings: • Ez. 37:12-14 • Psa. 130:1-2, 3-4, 5-6, 7-8 • Rom. 8:8-11 • Jn. 11:1-45 We live in a time of astounding scientific breakthroughs and unprecedented medical marvels. In my lifetime alone, we’ve witnessed men landing and […]
Data Science Use Cases: 15 Real-World Applications Transforming Enterprise Operations
Explore 15 enterprise data science applications across manufacturing, healthcare, retail, and finance — with case studies, code examples, and proven outcomes.
Nuclear reactor developer X‑energy files for US IPO
X-energy has filed for an initial public offering in the United States, it said on Friday, as the reactor developer aims to tap growing investor enthusiasm for nuclear power.
Political Science study reveals how Americans decide who counts as a
The term “person of color” has grown increasingly common in American public life. A new Berkeley Political Science paper, “Who Counts as a ‘Person of Color’? The Roles of Ancestry, Phenotype,
Mark Robinson admits ‘I lied’ about CNN story
Former North Carolina Lt. Gov. Mark Robinson admitted he lied about a bombshell CNN KFile investigation during the final months of his 2024 gubernatorial campaign, uncovering his extensive history of posting inflammatory and racist comments on a pornography website.
Shelby’s Trio hosts Chamber of Commerce Business After Hours
Shelby's Trio hosted the Clarksville Area Chamber of Commerce Business After Hours event on Thursday.
Building scientists in Charlottesville: Inside the UVA Innovation Hub
The award-winning partnership between the city schools and UVA’s School of Education expands learning into the community.
Windows 11 is finally getting a movable taskbar
Microsoft is also working on a smaller taskbar option
Scientists Make a Major Breakthrough in Solving a Hair-Raising Mystery About Static Electricity
The findings can help explain the physics behind phenomena like volcanic lightning
Federal judge in Oregon rules US government overreached with transgender health care declaration
The judge’s ruling Thursday in Oregon is part of multistate lawsuit filed against the U.S. Department of Health and Human Services, its secretary, Robert F. Kennedy Jr., and its inspector general.
Abramson advancing research at intersection of health, inequality and AI
Corey Abramson's research earns him a year in residence at the Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford University.
Welcome 2 New Restaurants to East Carson Street Business District
Mayor O'Connor and South Side Chamber of Commerce Welcome 2 New Restaurants to East Carson Street Business District
At UN, Holy See allies question reliance on hormonal treatments for women
The event was co-sponsored by the Fertility Education and Medical Management Foundation, a U.S.-based group that created an app that encourages women to track their cycles.
Aditya Kaddu
My goal is that my career path always enables me to create real, positive impact on others.
2026 NFL Draft Profile: Vanderbilt tight end Eli Stowers
The Denver Broncos need to add talent to their tight end group. Vanderbilt prospect Eli Stowers is one they should consider.
Exclusive: Amazon plans smartphone comeback more than a decade after Fire Phone flop
In 2014, Amazon introduced its first smartphone, hoping to take on Apple and Samsung. Instead, the Fire Phone - overseen directly by founder Jeff Bezos - was scrapped in barely over a year, one of Amazon’s highest-profile flops.
What doctors wish patients knew about social media’s health impact
From mere FOMO to anxiety and depression, social media platforms can pose harms and benefits. Three physicians discuss how to balance the positive and negative impacts.
Verdict on Chatbots in Mental Health Screenings? Too Judgmental
Chatbots used in mental health screenings aim to reduce the stigma associated with seeking help and to expand access to needed services. Because they cannot cast personal judgment, chatbots are considered a neutral option for sharing mental health concerns. In a recent test of these common assumptions, however, a University of Texas at Dallas researcher […]
Albuquerque The Magazine Recognizes 7 UNM Health ‘Top Docs’ for 2026
UNM Health recognizes over 1,000 dedicated physicians who create advancements in medical care as they educate and develop the next generation of health care professionals and scientists. This year, UNM Health honors seven physicians recognized as 2026...
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Alien Life Could Look Nothing Like What We Expect. Here's How Microbes Beyond Earth Might Live Without Liquid Water
Like the lead character of “Project Hail Mary,” some scientists are proposing ways that life might exist beyond a star’s “habitable zone,” often considered the gold standard of potential livability
Temple Health Appoints Robert A. Winn, MD, as Cancer Center Director for Fox Chase Cancer Center
Temple Health today announced the appointment of Robert A. Winn, MD, as the next Cancer Center Director for Fox Chase Cancer Center, marking a defining moment that will shape the future of one of the nation’s leading National Cancer Institute-designated Comprehensive Cancer Centers.
Trump admin. launches investigation of states mandating health insurance covers abortion
The Trump administration said Thursday that it has launched investigations into 13 states - including Oregon and Washington - that require state-regulated healt
Lawsuit Accuses Justice Dept. Leadership of ‘Political Retribution’
The suit filed by two fired F.B.I. agents aimed to hold the Trump administration accountable for the purge of personnel who had worked on the investigations of Mr. Trump or his allies.
Babson Taps Multigenerational Business Leaders for 2026 Commencement Addresses
CEO and Executive Chairman of Metropoulos & Co. C. Dean Metropoulos '67, MBA'68, will give the undergraduate Commencement address, with Cisneros CEO Adriana Cisneros speaking at the graduate Commencement ceremony.Wellesley, Massachusetts--(Newsfile Corp. - March 19, 2026) - Babson College will honor the achievements of more than 740 undergraduate and 540 graduate members of the Class of 2026 before thousands of family members, faculty, friends, colleagues, and peers in separate on-campus...
Xiaomi releases new lightweight laptop with Intel Panther Lake and 120 Hz OLED display
Xiaomi has released a new 14-inch laptop featuring Intel's Panther Lake platform. Available with up to 32 GB of RAM, the Book Pro 14 combines a 120 Hz OLED display with 72 Wh battery inside a housing that tips the scales at barely over a kilo.
Science stars at special UChicago, Argonne screening of ‘Project Hail Mary’
Researchers and students marked the new film with a panel discussion, hands-on science demos and a shared love of discovery
Dan Nelms
I realized Stanford GSB could help round out my skill set and prepare me to be an executive for a growth startup.
Cycle Nova: Villanova students unite to honor a legacy and advance heart health
Villanova, Pa., March 17, 2026 — Beat for Good, Villanova University’s student‑run organization dedicated to supporting individuals and families affected by cardiovascular disease, hosted its inaugural cycling fundraiser, Cycle Nova, on Saturday, March...
High School Students Present Ideas to St. John’s Experts in Tobin Business Plan Competition
Area high school students brought their business visions to St.
Interventional radiology breakthrough in portal vein thrombosis treatment
A UCLA Health interventional radiologist has successfully performed the first pediatric percutaneous spleno-renal shunt procedure to treat severe portal hypertension in a 6-year-old patient. This minimally invasive procedure aims to relieve complications associated with portal vein thrombosis, showing promising long-term outcomes.
What sports can teach us about Houston: Black Houston(s) Symposium returns to Rice
The fourth annual event will take place over March 26-27, bringing scholars, athletes, artists and community members together to examine sports as a social and cultural force.
Cone Health to Cut Ribbon on Two New Mobile Health Units
Two New Mobile Units Launch To Meet The Needs of the Community
A public health professor is bringing the National Bioethics Bowl to Pitt
The competition, organized this year by Cindy McCarthy, gives students a chance to consider challenging questions about health and technology.
HHS’ Office for Civil Rights Investigates Thirteen States Under Federal Conscience Law
HHS today announced investigations of thirteen states under a federal health care conscience law—the Weldon Amendment.
Sangamon County voters approve new tax increase for mental health board
Murphy explained that the mental health board would act as a centralized organization that helps coordinate groups and providers in the Sangamon County area.
Crimson Desert studio Pearl Abyss sees share price plummet by nearly 30% after first reviews arrive
The visually stunning adventure game isn’t reviewing as well as the market had hoped…
A clarinetist, a high school student, and four climate deniers write a science paper, with a little help from AI…
Papers like this are like kindling for anyone 'just asking questions' about climate change, or 'doing their own research,' stoking the flames of climate denial.
Leading Chinese remote-sensing scientist Zhang Jinshui dies at 47
Beijing Normal professor led major R&D programmes and was instrumental in enhancing the country’s food security with satellite technologies.
Sandhills Calving System continues to protect calf health, ranch profitability
Twenty-five years ago, a collaboration between a Sandhills ranch family, a rural veterinarian and Husker researchers led to a management innovation that transformed how cattle producers prevent calf scours. Known today as the Sandhills Calving System, the approach has become one of the most widely recommended strategies for preventing neonatal calf diarrhea.
HHS announces first Rural Health Transformation Program funding opportunity to strengthen rural health care workforce | Health and Human Services North Dakota
North Dakota Health and Human Services (HHS) today announced the first Rural Health Transformation Program funding opportunity is now available to support the retention of health care professionals in North Dakota’s 37 critical access hospitals and their owned and operated clinics. The deadline to apply is 5 p.m. CT April 30.
UCS vs Anti-Science Actions
We're suing the Trump administration on a wide range of issues—and winning.
Medicaid drug reimbursements could end for health care providers across Indiana
Health centers warn they could lose millions in rebates under the states proposed change, which would end Medicaid drug rebates for health organizations.
Lenovo brings retro arcade cabinet gaming to high-end Android tablets with new releases
Lenovo has released a new set of accessories for its compact gaming tablets. Compatible with multiple tablet generations, the Legion Y700 Arcade Dock comes in three finishes with dedicated SNK versions too.
It’s Time for the Epstein Class to Make Amends
The files released by the Justice Department feed into populist discontent.
It’s Time for the Epstein Class to Make Amends
The files released by the Justice Department feed into populist discontent.
Seth Cohen to become new dean of UC Irvine's School of Physical Sciences
Renowned leader in advanced chemistry research will assume new role Aug. 1
Q&A: Is there no shame left in politics?
There is some, a UVA expert says, but the public has become accustomed to bad behavior.
Pursuing a passion for public health
MIT senior Srihitha Dasari has embraced a holistic and community-informed approach to medicine and public health. She also co-founded a social impact venture, PuntoSalud, working with a hospital in rural Argentina.
Science-minded student charts research, service path at Penn State
When Eva SinhaRoy arrived at University Park a couple years ago, she was a little overwhelmed at the possibilities. The science-minded student knew she wanted to focus on research, but she also wanted to build skills in other areas such as leadership. Since then, she's found her place in undergraduate research, leadership, and campus activities such as THON and the Presidential Leadership Academy.
Pope Leo calls universal health care a 'moral imperative'
States have a moral obligation to develop universal health care systems, Pope Leo XIV said, stating that health cannot be "a luxury for the few."
EU Inc. – making business easier in the European Union
The Commission presented EU Inc., a new single set of corporate rules that will be the same and apply across the EU.
MORNING BUSINESS REPORT: Amazon delivery changes, airline booking surge
Changes may be coming to Amazon package delivery, and at least one major airline is seeing a jump in bookings amid concerns over possible ticket price increases.
Insurer and business lobbying interests kill supplemental breast imaging bill in 1 state
Earlier this year, Kansas lawmakers introduced Senate Bill 409, seeking to close insurance gaps for women who need follow-up scans after screening mammography.
Nasal Swab Test Spots Early Alzheimer’s Signals
DURHAM, N.C. – Alzheimer’s disease affects millions of people worldwide, yet the illness is hardest to catch at the very beginning, when new treatments may work best.In a new study, Duke Health researchers show that a quick, outpatient nasal swab can pick up early biological changes linked to Alzheimer’s, even before thinking and memory problems appear.
How sports traditions like March Madness can support brain health
Three experts from the University of Kentucky say the answer may be yes. Research shows that staying mentally, socially and emotionally engaged can help support long-term brain health. Activities tied to sports — like predicting tournament outcomes, reminiscing about past games or gathering with friends and family to watch — can stimulate memory, strengthen cognitive skills and foster meaningful social connections.
Paleontology has an Epstein problem. Women in the field say it's a symptom of a deeper misogyny
The names of hundreds of scientists have appeared in the Epstein files, including prominent dinosaur researchers. As the paleontology community reckons with the fallout of these revelations, women in the field say it's bringing to the forefront what they've known for years — that paleontology is ripe with abuse and harassment, and its institutions protect men at the top at the expense of women trying to build careers in spaces that treat them as disposable.
Deputy AG Blanche defends DOJ’s work on Epstein case ahead of closed-door Hill briefing
Deputy Attorney General Todd Blanche, ahead of his appearance on Capitol Hill Wednesday, defended the Justice Department’s handling of the Epstein files and asserted it does not have new evidence to prosecute anyone for crimes related to Jeffrey Epstein, in an interview released Tuesday that forced him to face theories plaguing the department.
WhatsApp update brings the new profile tab to iOS users
Following a few weeks of testing, WhatsApp is officially rolling out the new profile tab to iOS users. Here are the details.
Kalshi's legal troubles pile up, as Arizona files first ever criminal charges over 'illegal gambling business'
It's the latest salvo in an escalating battle between state regulators and an industry that claims it's not beholden to them.
Arizona files landmark criminal charges against prediction market Kalshi
Arizona’s attorney general has filed the first-ever criminal charges in the US against a major prediction market company, accusing Kalshi of running an illegal gambling operation in violation of state law.
Indiana commits $1B to attract high-wage life science jobs
Indiana is dedicating $1 billion to further growth of agriculture and life science businesses and jobs to the central Indiana area over the next 10 years.
Spotify adds ‘Exclusive Mode’ audiophile feature for Windows PCs
Spotify gets bit-perfect playback.
Machine learning analysis of CT scans
An AI-powered tool can interpret 3D images from CT scans and diagnose certain disorders.
City of Johnston files lawsuit against developers of Ignit sports complex
The city of Johnston is suing the developers of the Ignit sports complex for more than $3.6 million in damages.
Allina Health to Join Sutter Health, Creating Bold Vision for Nonprofit Healthcare
United by a shared mission, trusted nonprofit health systems have a unique opportunity to advance innovations that strengthen quality and extend care to more patients NORTHERN CALIF. and MINNEAPOLIS — Sutter Health and Allina Health have signed a Letter of Intent (LOI) for Allina Health to join the California-based system, which would create a combined […]
Arizona Charges Kalshi With Operating Illegal Gambling Business
Arizona said it filed criminal charges against Kalshi for operating an illegal gambling business in the state.
Kalshi charged criminally in Arizona for operating illegal gambling business
Arizona's attorney general on Tuesday filed criminal charges against Kalshi, accusing the prediction markets platform of operating an illegal gambling business in the state and unlawfully allowing people to place bets on elections.
AGU and Content With Purpose announce new digital series exploring science in action
“Our World, Our Future” will connect scientific discovery with lived experience and demonstrate how research directly affects people and communities everywhere.
Magic mushroom-infused products appear in Colorado gas stations – what public health officials want consumers to know
Hallucinogenic chocolate bars were removed from six Denver-area gas stations.
Science the star at special UChicago, Argonne screening of “Project Hail Mary”
Argonne and UChicago hosted an advanced screening of "Project Hail Mary." The event featured an expert panel on how the film's science resonates with real-world research. UChicago students also hosted hands-on science demos in the theater lobby.
Court filings shed light on McGlinchey debts, assets as firm is dissolved in bankruptcy
Documents filed in the McGlinchey Stafford bankruptcy case shed new light on the New Orleans firm’s financial situation in the wake of its surprise decision early this year to shut