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Green Bay Packers vs. Detroit Lions: How to watch the NFL Week 7 game, channel, streaming info and more
This Week in Purple: Around The World (Series)
Colorado Rockies news and links for Sunday, October 25th, 2026
Browns sign Maliek Collins to $30 million extension
The Cleveland Browns have secured one of their standout defensive players for the future before their next game against the Tennessee Titans . Cleveland defensive tackle Maliek Collins has agreed to a two-year contract extension worth $30 million. According to NFL insider Ian Rapoport, Collins’ agent, Drew Rosenhaus, confirmed the agreement to him […] The post Browns sign Maliek Collins to $30 million extension appeared first on ClutchPoints.
Browns Week 7 fantasy start-sit: Boston, Judkins, Fannin, Concepcion
Tennessee has allowed the 10th-most half-PPR points to receivers, while Dylan Sampson’s return from injured reserve threatens Quinshon Judkins’ receiving work.
Health board still paying for research despite criticism over patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
Baltimore Ravens vs. Cleveland Bengals Week 6 game discussion
Join the discussion about the Ravens’ Week 7 matchup with the Bengals!
Investment driving growth at NWS Crane
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How to Watch: Arizona Cardinals vs. Denver Broncos
Everything you need to know about the Arizona Cardinals game against the Denver Broncos.
3 comments | Progressive Democrats are closely watching four Senate...
Progressive Democrats are closely watching four Senate races in the upcoming midterm elections. Our politics reporter Kellen Browning explains why.
Nevada's Republican governor fights to survive Trump undertow
Joe Lombardo is no MAGA warrior, but his Democratic opponent ties him to the president at every opportunity. Lombardo hopes Nevada voters judge him on his performance, not Trump's.
‘Talking to every single person matters’: ‘prairie populists’ canvass the rural US heartland to win in midterms
Democratic and independent candidates stump the US midwest and prairie states, hoping to win over Republican strongholds
2026 Vanderbilt Football Mailbag #9: Call For Submissions
Post VANDERBILT Football and/or SEC Football questions in the comments here. It’s becoming more and more obvious we’re highly unlikely to win another game this season. Our defensive calls make no sense, we’ve got an uber-talented but uber-raw QB learning on the jerb, and Barton Simmons’ decision to staff our O-Line exclusively with matadors has […]
Opinion - How Trump learned to stop worrying and love space science
He recognizes a cool thing when he sees it.
Arkansas basketball displays true toughness against Gonzaga
The big story of the win over Gonzaga: These Hogs play defense
Steelers vs Saints live updates, TV info, start time, stream NFL Paris game
The Steelers are in the middle of a AFC North divisional dog fight as they look to win the first NFL regular season game on French soil.
Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
Maliek Collins agrees to terms on contract extension
Maliek Collins to remain in Cleveland for two additional years
The top 25 modern golf courses in Canada, ranked
Our ranking of top modern Canadian courses returns, with Nos. 1 and 2 sitting side by side.
NH's Business: Healthcare affordability for NH residents
Fred Kocher sits down with Maria Proulx with Anthem Blue Cross, Blue Shield to talk about healthcare affordability for NH residents.
Norman Powell: "I feel like this is another …
Norman Powell: "I feel like this is another …
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
Cam Skattebo Update: Will Giants Star RB Play Against Texans?
New York Giants share news on RB Cam Skattebo after benching in Week 6. The post Cam Skattebo Update: Will Giants Star RB Play Against Texans? appeared first on HEAVY.
Warriors honor Bay Area sports reporter Michael Wagaman
After Michael Wagaman passed away in early August, Dallas Braden took time to tribute him during his call of the Athletics’ game on NBC Sports Bay Area and California. Wagaman had covered Bay Area sports teams since 1996, including for the Associated Press, and freelanced for NBC Sports Bay Area and California at the time…
Chair of 'submarine affair' committee probing Netanyahu resigns due to health concerns
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Gyökeres May Not Be Scoring, But He’s Helping Arsenal Win
Viktor Gyökeres is still waiting for his first Premier League goal of the season, and for a striker of his reputation, that’s always going to attract attention.But are we becoming too focused on wh...
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
‘Monster Mash’ still makes a bunch of $ each year
“I have been paying the rent for 36 years with this one song,” co-writer and performer Bobby “Boris” Pickett—aka the Mariah Carey of Halloween—told the Memphis Commercial Appeal in 1998.
Tractor-trailer crash closes part of US-70W Business
Two lanes are closed on US-70W Business after a crash involving a tractor-trailer.
Google’s AI search changes upended online publishing
Some publishers are preparing for a future without Google.
Halifax Health Sees 19 Biketoberfest-Related Injuries in 2026
With Biketoberfest 2026 having ended on October 18, Daytona Beach’s Halifax Health Medical Center announced the statistics on injuries related to the event. 19 patients were treated for injuries …
Interest rates unlikely to reach 4.75% by next summer, say City economists
Experts say Bank of England unlikely to increase rates by full percentage point – and could lower them by end of 2027
EXHIBITION GAME THREAD: RV Marquette vs #6 Michigan State
It’s mostly real basketball at Fiserv Forum, what’s not to like?
Turnovers continue to plague the Cavs in the fourth quarter
“There’s no excuses, but we are working on it,”
Why crafting is good for your brain, according to science
Knitters and other crafters say busy hands quiet their minds. But experts say there are also benefits for cognition.
Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links
Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links New York City, USA, Oct. 25, 2026 (GLOBE NEWSWIRE) -- Founded by Rollo Unden and Oliver Fish, Unfair Links builds local backlinks matched to a business's Google Business Profile, country and language, and is now taking sign-ups for its beta waitlist. Unfair Links, a new link building
How to catch the hunter’s moon this weekend
An orange-colored full hunter’s moon will reach peak brightness early Monday morning along with a potential glimpse of Saturn.
Bloomington business continues to blossom
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South Texas Health System (@stxhealthsystem)
2 likes, 1 comments - stxhealthsystem on October 25, 2026: "One Last Chance to Think Pink: Breast cancer remains the most common cancer among women after skin cancer, making routine screenings and early detection more important than ever. Mammograms can help identify breast cancer before symptoms appear, when treatment options may be most effective. Last week, South Texas Health System McAllen celebrated breast health and preventive care with a special Mammo Monday event featuring the vibrant sounds of mariachi music at the hospital’s main entrance. The celebration reflected STHS' ongoing commitment to encouraging women to prioritize their health through regular screenings. Now, there’s one final Mammo Monday remaining! Join us at STHS ER Mission on October 26 from 8 a.m. to 5 p.m. for the last breast cancer event of 2026. During the event, attendees can: 🎀 Learn about breast cancer screening options 🎀 Schedule a mammogram appointment 🎀 Receive a complimentary goodie bag while supplies last To help make preventive care more accessible, South Texas Health System is also offering reduced self-pay rates* throughout October: • 2D Mammogram: $100 • 3D Mammogram: $155 • Bone Density Screening: $160 A screening today could make all the difference tomorrow. Make your health a priority and encourage the women you love to do the same. For breast health resources and information on the Think Pink campaign, visit the link in our bio. *If not already a covered benefit of your insurance.".
Kochetkov Earns Shutout
Pyotr Kochetkov improved his record to 7-0-0 with a 24 save shutout and the Carolina Hurricanes defeated the St. Louis Blues on Saturday night, 4-0. The Hurricanes now have a 9-2-2 record and their 20 points put them at first place in the league, (for now). The Canes finished up their road trip with a […]
Americans have a grief problem we still call a mental health problem
OPINION — Americans have become much better at talking about mental health. We have learned words such as trauma, post-traumatic stress disorder, depression, anxiety, burnout, compassion fatigue and moral injury. That vocabulary matters.
Clifton ‘Jackie’ Jackson: A towering gentleman of the bass
Clifton ‘Jackie’ Jackson embodies Robert Farris Thompson’s classic concept of the ‘aesthetic of the cool’, also referred to by the ancient Yoruba concept of itutu. He was the elegant bassist whose lines were as refined as his demeanour. Calling him the ‘Rolls-Royce of Reggae Bassists’ isn’t to suggest he didn’t roll with some of the deepest, lilting roots grooves like others. He added an unmatched touch, poise and musical sophistication to the bottom end while retaining every bit of the heavy, syncopated pulse required for authentic Jamaican music.
The Political Upstarts That May Decide Israel’s Election
The upcoming Israeli election may be decided by two small parties that didn’t even exist a few months ago.
Political analysis favors Mendoza over Ciscomani
The Cook Political Report has switched its assessment of the congressional race for the House seat from a “toss-up” ranking to “Leans Democratic.”
Aaron Ashby approaches history with latest dominant performance for Brewers
The lefty reliever has been the Brewers' best pitcher this postseason.
Sunderland vs Leeds – Predicted lineup and team news
Sunderland host Leeds United at the Stadium of Light on Sunday, looking to move away from the bottom of the Premier League standings and end a difficult run of results.The Black Cats head into the gam...
Michigan Gov. Gretchen Whitmer says America is ready to elect a Woman
The Michigan governor did not deny that she was exploring a potential run for president in 2028.
Renee Minogue is helping shape her husband's gubernatorial bid
The 52-year-old mother and wife of GOP gubernatorial candidate Michael Minogue is a full-blown political influencer.
Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
During the hike, participants wore military short-shorts known as “silkies” as part of the event’s tradition to foster connection.
Patriots rooting guide for NFL Week 7
Rooting information, kickoff times, TV schedule and more for NFL Week 7.
NFL Week 7 Game Discussion and Open Thread
Talk about all the Week 7 NFL games with us here!
Sunday Night Football: How to watch the Kansas City Chiefs vs. Seattle Seahawks game tonight
How Nathan Fielder's cringe-comedy career led him to Elizabeth Holmes
Spoiler alert! We're discussing the themes and structure of the Elizabeth Holmes documentary "You Can See Everything" and touching on a surprising aspect of its second half, so turn away if you want to go in completely cold.
Memorial Health celebrates staff with trunk-or-treat
Memorial Health went all out for its annual trunk-or-treat event, celebrating team members and their families.
Country music star retiring at 51: ‘Now that I’m leaving it’s gonna completely suck’
The singer is calling it quits when his tour is finished.
World's Fastest Lawnmower Company Is Officially Going Out Of Business
Dixie Chopper made the world's raddest lawnmowers for almost half a century, but its story is now coming to an end.
Paris Pressure: Saints Must Block Out the Chaos and Finish Their Business Against the Steelers
NFL.com Experts Rolling With Broncos In Week 7
Fresh off a gritty win, Denver faces an injury-riddled Arizona squad as analysts eye a potential breakout performance for Bo Nix against the struggling Cardi...
Jaylen Brown responds to Jayson Tatum's 'no beef' comments as dispute continues: 'He's got a great PR team'
How Braves should handle $42 million Jurickson Profar situation
This could be one solution for the Braves.
New York Giants' Never-Ending Nightmare Might Get Even Worse
Things just keep getting worse for the New York Giants.
r/opensource just banned AI, non-English speakers and more
The opensource subreddit’s new rules against AI have sparked a revolt.
‘Healthy’ daughter, 26, dies suddenly—now family think they know why
Her grieving sister told Newsweek she had no idea her sibling's unusual flexibility was a sign of a "deadly condition."
Clemson HC Dabo Swinney Puts Coach on Notice, Offense 'Disturbing'
After a deflating loss to Virginia Tech, Swinney confronts roster gaps and coaching failures as the Tigers' playoff hopes vanish and the offense faces a critical crossroads.
Scientists Find Chronic Back Pain Activates a Brain Network Linked to Personal Identity
A new UC San Diego brain imaging study involving 114 adults suggests that chronic back pain flare-ups affect brain networks involved in self-reflection and personal memories. The findings may help exp...
Colts Make Roster Moves Ahead of Sunday's Matchup
The Indianapolis Colts made roster moves ahead of Sunday's matchup against the Minnesota Vikings.
YouTube Gold: Highlights From Louisville’s Trip To Kansas
Kansas lost Wednesday, but the Jayhawks are not exactly pushovers
Texas opens as heavy favorite against Mississippi State
The Longhorns are three-score favorite as they welcome the Bulldogs to Austin.
🎥 He's already on a yellow! Linesman sends player tumbling
It's the refereeing team's job to make sure a match is as fair as possible and the players stay on their feet. But that definitely doesn't always work out.During the clash between Monterrey and Guadal...
Denzel Ward to take part in pregame warmups
Denzel Ward's status for Week 7 remains in question
Who can buy California's voter rolls and why?
Chris Micheli, an adjunct professor at McGeorge School of Law and longtime lobbyist, explained who is able to buy the voter rolls and why in an interview on California Politics 360.
Celtic Confirm Good News Ahead of Game vs Hibernian
Celtic have confirmed some good news ahead of the game against Hibernian.
Brazil votes in a tense Lula vs. Bolsonaro runoff with U.S. influence over Latin America at stake
The election pits the left-of-center veteran politician Lula against Bolsonaro, an ally of U.S. President Donald Trump and the son of imprisoned former President Jair Bolsonaro.
Voters in 2 Democratic strongholds could ban transgender girls from girls school sports
Reliably Democratic Colorado and Washington have ballot measures that would bar transgender girls from some sports competitions
Country music star retiring at 51: ‘Now that I’m leaving it’s gonna completely suck’
The singer is calling it quits when his tour is finished.
Is having urine the color of Mountain Dew normal?
A Trump administration doctor says neon yellow urine is normal because of diets consisting entirely of meat and fermented foods. Here’s what experts say
How to watch Lions vs. Packers: TV, streaming, radio, more
TV, online streaming, announcer, and kickoff time information for Detroit Lions vs. Green Bay Packers.
Gov. Meyer announces the inclusion of the Verizon BEAD Project
Governor Matt Meyer announced the addition of the Verizon Broadband Equity, Access, and Deployment (BEAD) project to the JobsFirst Accelerator program.
Adam Schiff responds to DOJ’s Alaska threat: ‘it’s Alaska’s business’ to run elections
In an exclusive interview with Meet the Press, Sen. Adam Schiff (D-Calif.) says “it's not the federal government's business to run Alaskan elections,” after the Justice Department sued to block certification of Alaska’s election results if Sen. Dan Sullivan loses, due to another candidate with the same name appearing on the ballot.
Udinese vs AC Milan – Match preview and team news
AC Milan will aim to get inside the top four of the Serie A league table by securing all three points when they meet Udinese on Sunday away from home in their next match.Udinese vs AC Milan – Match...
USC Legend Tells Lincoln Riley "It just Ain't Working Out" as He Calls for "Tough Decisions" at His Alma Mater
Lincoln Riley is running out of excuses, and USC is running out of patience. Just a week after showing promise against Penn State, the Trojans embarrassed themselves in a 24-7 loss to Wisconsin, exposing an offense that looked completely lost.
Pat Surtain II unlikely to play
Pat Surtain has good chance to suit up in Week 8 due to ankle injury
🚨 Barça's squad to face Real Madrid
Barcelona have just announced Hansi Flick's squad for tonight's Clásico against Real Madrid at the Spotify Camp Nou. Midfielder Orian Goren is the standout inclusion in Flick's 23-man squad. Reserve-...
What happened to the cast of ‘I Dream of Jeannie’? See the stars more than 55 years later
‘I Dream of Jeannie’ paired Barbara Eden’s genie with Larry Hagman’s astronaut for five seasons of magic. See what became of the cast more than 55 years after the final episode.
Steelers Get Good News on Rico Dowdle
Pittsburgh Steelers running back Rico Dowdle (knee) is active for Sunday’s game against the New Orleans Saints in Paris after […]
Arsenal squad & fixtures for the 2026 Messi Cup
The 2026 Messi Cup kicks off on Sunday, with Arsenal’s squad and fixture list for the tournament now confirmed.Photo by Elsa/Getty ImagesThe Arsenal u16s will take part in the Messi Cup this year, w...
Micron Just Revealed a New Business Strategy. That Change Makes It a Screaming Buy.
Micron is changing more toward contracts, rather than letting the open market dictate pricing.
Mateer Manages Himself and Mississippi State in Win
Silencing critics in Starkville, John Mateer delivered a poised, turnover-free performance to ignite the Sooners' offense and justify Brent Venables’ unwavering faith during a high-stakes road victory.
Hurricanes Tried to Acquire Forward in Hellebuyck Trade Push
The Carolina Hurricanes tried to land a forward, as they looked to make a serious push for Connor Hellebuyck. The post Hurricanes Tried to Acquire Forward in Hellebuyck Trade Push appeared first on HEAVY.
Scientists Trapped an Antimatter Particle for Months to Study Its Secrets
These elusive and reactive particles have been challenging to hold on to and even more challenging to study, but a new method paves the way for tests on the differences between matter and antimatter.
Open Thread, Sunday, October 25: How we doing today, folks?
Your daily source for off topic chatter with the MMA Mania faithful.
How to build a police state
To understand where Trump is trying to take the US, we should look to the authoritarian playbook of his favorite ally: El Salvador’s Nayib Bukele
Amid first 0-3 start since 2007, Giannis-led Heat searching for answers: ‘We’re not in panic mode’
The Heat’s Giannis Antetokounmpo era is off to a rough start.