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Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)
World's first Formula E karting experience in Abha fuels Saudi Arabia's motorsport future
The pioneering indoor attraction at SEVEN Abha has already seen thousands of guests as visitors experience the world's only Formula E karting destination.
How the BJP is reorganising Indian politics
The BJP directly won only one of India’s four 2026 state elections, yet a wider political reorganisation may have brought its alliance closer to a two-thirds majority in the Lok Sabha
Germany win Men's Hockey World Cup, equal Pakistan's record; Abhay Singh wins 13th PSA Tour title: Indian Sports, August 30
Here are all the updates from Indian sports on August 30, 2026.
Saudi Entertainment Ventures opens first Seven entertainment destination
Saudi Entertainment Ventures has opened Seven Abha, marking the first operational destination in its planned nationwide portfolio of integrated entertainment centres.
Less sleep = less health; Led Zeppelin in the OR; dangers of people-pleasing; plus other stories with Vanderbilt Health sources
Prevention interviewed Beth Malow, MD, Professor of Neurology and Pediatrics in the Vanderbilt Sleep Division, for a story about two randomized trials published in Annals of Internal Medicinethat found decreasing sleep by just 1.5 hours each night was linked with increases in body weight, waist circumference, and sedentary time in adults with elevated cardiometabolic risk. Yahoo Healthalso picked up the story. WTVF News Channel 5 reporter Nikki Hauser interviewed Ashish Shah, MD, Professor and Chair of Cardiac Surgery, for a new video podcast series called “Why Nashville” where she interviews interesting people doing interesting work about why they came to Nashville and how it is going. Among the revelations: his go-to OR music includes Led Zeppelin and AC/DC. Everyday Health interviewed Aaron Brinen, PsyD, Assistant Professor of Psychiatry and Behavioral Sciences, for a story about the TikTok trend that encourages women to speak up about their concerns or they’ll develop an autoimmune disease. Overall, people suggest that suppressing feelings of anger, minimizing your own needs, or people-pleasing raises your risk. Telemundo Nashville broadcast a story on cyclosporiasis that quotes both William Schaffner, MD, professor of Preventive Medicine, and Juan C. Salazar, MD, MPH, chair of the Department of Pediatrics and system Pediatrician-in-Chief for Monroe Carell Jr. Children’s Hospital at Vanderbilt. Schaffner also spoke to WKRN News 2 about measles and The Cutabout shingles and long distance running. WREG (Memphis) and others picked up the measles story as well. CNN reporter Deidre McPhillips interviewed John Trahanas, MD, Assistant Professor of Cardiac Surgery, and Director of Thoracic Aortic Surgery, for a story about aortic dissection in last week’s death of U.S. Sen. Lindsey Graham. The Nashville Post published a story by freelance reporter Leah Hunter on robotic surgery, including a patient story and numerous quotes from Sekhar Padmanabhan, MD, Assistant Professor of Surgery in the Division of Surgical Oncology.
Thai Tycoon Revamps Property Business To Unleash Growth
Panote Sirivadhanabhakdi, son of liquor tycoon Charoen Sirivadhanabhakdi, has been making moves to revamp the family’s real estate portfolio held by Singapore-listed Frasers Property.
Seven's first entertainment destination to open in Abha
Seven is investing SAR 50 billion ($13bn) in the development of 21 entertainment destinations
Brewers' win over the Reds featured 3 desperately needed performances
Three Brewers mired in deep funks came up big to help beat the Reds on June 29 at American Family Field.
The politics of intergenerational wealth inequality
Letters: Dr Rajiv Prabhakar assesses the best age at which grants should be provided to young people, while Jeremy Galtress argues against redistribution
Google’s chief technologist delivers talk at Rice on role of AI in math and computer science research
Prabhakar Raghavan, chief technologist at Google, was the featured speaker in the Ken Kennedy Institute Distinguished Lecture Series.
Things to do this weekend in Metro Detroit
Concerts, comedy, dance and more are on deck around town this weekend, April 10-12.
Cardiac Electrophysiology Expertise Now Offered at UAMS Health Family Medical Center in Fort Smith
LITTLE ROCK — The University of Arkansas for Medical Sciences (UAMS) Health Heart Center now offers comprehensive cardiology services at the UAMS Health Family Medical Center in Fort Smith. The services are provided by cardiologists Subodh R. Devabhaktuni, M.D., Risheek Kaul, M.D., and Paul Mounsey, M.D., Ph.D. Cardiology services…
Mid-Ohio Valley Spring Sports: Roane County Raiders schedule
Baseball Head coach: Larry Ash, 2nd year Assistant coaches: Matt Ash, Will Starcher Last year: 9-12 Roster Seniors 3 Jacob Greathouse (C/P), 8 Caden Caldwell (2B/MI), 16 Hogan Greathouse (DH/OF), 23 Carder Kinder (CF/P/UTL) Juniors 9 Brodey Proctor (LF), 11 Carson Casto (OF), 15 Alex Richardson (C/3B/P), 22 Reis Thornabar (1B/P) Sophomores 1 Wyatt Brabham […]
The accidental climate scientist who uncovered an unexpected force of global warming
The Swedish Royal Academy of Sciences has awarded the Crafoord Prize to climate scientist Veerabhadran Ramanathan. He discovered a powerful force of global warming.
From Superconductors to Black Holes, USU's Science Unwrapped Tackles Big Questions on Jan. 23
USU physicists Abhay Katyal and Oscar Varela are the featured speakers at the free, family friendly event on Jan. 23