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Employer Political Activity During the 2026 Midterms: Key FAQs
As the 2026 midterm elections approach, employers may have questions about whether (and how) they can support candidates or political positions. This FAQ addresses common questions about company political activity, communications with employees, mandatory political meetings, and political contributions.
Hugging Face’s New AI Biology Model Lets You Chat With DNA
The new open-source model speaks the language of DNA and can help researchers understand the effects of any changes on gene activity and health.
Sun Prairie considers new massage business regulations after police receive complaints
Sun Prairie leaders are considering new regulations for massage establishments following complaints to police about activity at certain businesses.
China builds the world’s smallest wearable brain monitor with a cortex-wide view
The Airscope offers a window on the simultaneous activity of thousands of individual neurons in untethered lab animals.
Natasha Lyonne sparks controversy with 'prefer Trump' social media post
Natasha Lyonne's recent social media activity has upset some fans, who are accusing her of supporting President Donald Trump.
Bridging the gap: Western student earns Fulbright to study wildfire science in Australia
“The goal is to identify the drivers behind intense wildfire activity and the ecosystems and communities they could impact” When Dalton Robberson finally got to the point of choosing …
Chinese scientists find neurons may act as minicomputers to help decision-making
Researchers find evidence that suggests neural activity can guide the way the brain adapts to different sensory experiences.
Uzbekistan's $12bn business drive gathers pace during Rubio visit
The package covers railways, critical minerals, finance and technology, with major US firms involved. Uzbek President Mirziyoyev outlined measures to attract investors, while business executives told Euronews that commercial activity is growing.
Your age may not tell the whole story about how healthy you are
Researchers developed a five-factor Lifestyle Index assessing physical activity, BMI, smoking, sleep quality, and sexual satisfaction in 312 Swiss adults aged 35 to 65 years. Higher scores were modestly associated with younger bio-functional age, suggesting a relationship between combined lifestyle patterns and functional health, although the findings cannot establish causation.
Flu activity is rising earlier than usual in El Paso County, health officials say
Respiratory illness season is underway in El Paso County, and local health officials say flu activity is already increasing earlier than typically expected.
Researchers Discover a Blood-Pressure Drug May Stimulate “Healthy” Brown Fat
Losartan, a drug commonly prescribed for high blood pressure, boosts brown adipose tissue or “brown fat” activity and enhances its metabolism, according to a preclinical study by Weill Cornell Medicine, Rockefeller University and Memorial Sloan Kettering Cancer Center researchers.
CCIA Study Finds South Korea Fines U.S. Companies Up to Seven Times More Than Korean Firms Relative to Business Activity
Washington – A new study by the CCIA Research Center finds that South Korea’s competition authority imposes penalties on U.S. companies at rates four to seven
Are babies conscious in the womb before birth? Here’s what science can and can’t prove
The fetal brain is doing far more before birth than scientists once understood. The difficult question is where complex brain activity ends and conscious experience begins.
Scientists Uncover a Hidden Factor That Could Change How We Manage Diabetes
Timing may matter in insulin-treated type 2 diabetes; patients with the steadiest daily rhythms were 2.3 times as likely to meet blood sugar goals, while afternoon activity was linked to smaller swings. People with type 2 diabetes who use insulin need to keep blood glucose from climbing too high or falling too low. In a
Three teens charged after string of business break-ins in Baltimore County
Baltimore County police have arrested and charged three teenage boys after a string of commercial burglaries across the county.According to police, detectives a
Old Forge Library offers free Halloween activity bags for children
Old Forge Library offers free Halloween Grab N' Go craft bags for children ages 4-11, plus a Halloween party and trick-or-treating activities.
What’s on the Sun’s hidden side? Scientists uncover new clues
A new study reveals how scientists can identify previously unseen solar activity and build more accurate models of the Sun's magnetic field.
Walking, Yoga, or Zumba? Which Exercises Help Relieve Menopause Mood Symptoms
A new review suggests that regular physical activity may help reduce depressive symptoms and improve quality of life during menopause.
NBA bans certain types of sports bets following high-profile gambling scandals involving players
The NBA is banning certain player prop parlays and other wagers while expanding measures to detect suspicious betting activity and protect players from harassment.
DC Lawmakers Focus on Business, Wealth Taxes in Budget Hearing
DC lawmakers held a marathon hearing Friday to debate different revenue raisers to fill a projected $700 million budget gap next year, but most focused on measures to implement a business activity tax and wealth tax.
Trump Administration Restricts Drone Activity Along U.S.-Mexico Border
The new restrictions ban unauthorized drone flights within a nautical mile of the southern border, up to 400 feet in the air.
Testimony: ITEP’s Nick Johnson weighs in on D.C.’s Business Activity Tax proposal
A D.C. Business Activity Tax, or BAT, meets commonly held standards for sound tax policy.
Kendall A. Schnurpel: The line between nonprofit advocacy and political activity
The executive director has already shared both items on her personal Facebook page, which lists her title.
NBA tells sportsbooks to ban certain bets and parlays: report
The NBA told sportsbook partners in a Friday memo to ban certain types of bets and parlays this season that gamblers used in recent wagering scandals, ESPN reported."There's a balance between ensuring that we are removing problematic bet types but also ensuring that we don't just move activity into the illegal market," NBA executive vice president Scott Kaufman-Ross told ESPN. "Where we landed right now, we think, is the right balance of those two objectives."
Your eyes dilate depending on your thoughts
Brain activity and verbalization can both affect our pupils.
Plague is stoppable. The next health threat may not be.
The word plague is scary. Centuries ago, the Black Death killed tens of millions of people and changed the course of history. Plague still kills people around the world, and the word still evokes catastrophe. New fears of plague surfaced on October 2, when a lab worker in Irkutsk, Russia, died of pneumonia. Reports suggested that she may have contracted plague through a laboratory exposure. Understandably, people were alarmed. On October 7, the World Health Organization called for the Russian Federation to be transparent about what it knew. WHO issued an update on October 10. Russian authorities told WHO that testing did not identify plague and that investigations found no laboratory release. WHO said confidence in its risk assessment remained limited and that further clinical, epidemiological, and laboratory information was needed. The cause of the woman’s illness remains unknown, and WHO says a laboratory-associated exposure cannot be excluded. As I explained in a recent interview, this incident is very unlikely to lead to a pandemic. Plague is still active, including in the U.S., which sees a handful of cases each year. But it is a disease we can prevent and treat. Plague doesn’t spread readily, and it responds to antibiotics. The standard response—isolate the patient, trace contacts, and administer antibiotics and monitor for symptoms among contacts for seven days—works. We have even planned for antibiotic-resistant plague. At CDC, we developed a playbook for antibiotic-resistant plague and ran exercises on how to find and stop it. CDC guidance anticipates engineered resistance and recommends two different classes of antibiotics if there’s reason to suspect it. There is no evidence that resistance—or even confirmed plague—is involved in this incident. We have thought through how to address plague, but we’re not ready for the next major health threat that emerges from a lab or from animal spillover to humans. What should concern people is how little stands between the world and the next pathogen to get loose. Since peak COVID, epidemic preparedness has fallen off the political agenda, but the risk is greater than ever. More labs handle dangerous pathogens with more ways to make those pathogens deadlier, and more people live and work in close contact with animals. There are actions we can take now: We need better lab safety in every country. The number of labs that work with dangerous pathogens has increased worldwide over two decades, but there’s no enforceable international standard and no inspection regime; the Biological Weapons Convention, fifty years on, still has no verification mechanism. Labs that study dangerous germs need strong safety systems, training, and oversight. We need to reduce spillover events. Three in four emerging human infections start in animals, and there’s a lot we can do to reduce spillover risk, but the world is doing very little of it. Live-animal markets are one place to act. For instance, closing live-bird markets helped control H7N9 influenza in China. Reducing opportunities for people to encounter infected animals can prevent infections before they become outbreaks. In The Formula for Better Health, which is now out in paperback along with the hardcover, Kindle, and audiobook versions, I argue that labs do too many risky experiments with too many dangerous pathogens in too many institutions, and that every experiment should first answer one basic question: Is the likely benefit greater than the risk? Spillover risk can also be reduced: In the book, I discuss how Brazil cut its deforestation rate by 70% from 2004 to 2012 while increasing agricultural production and reducing risky contact between people and forest animals. We need faster detection and response. Delay costs lives. Strong surveillance, good labs, and trained responders can turn a single case into a small cluster of infections instead of an epidemic. Resolve to Save Lives has worked for nearly a decade to help countries find and stop outbreaks faster. The 7-1-7 target, which Resolve to Save Lives developed with partners in Uganda and elsewhere, provides a clear standard: detect within 7 days, notify within 1 day and complete all essential early response actions within 7 days. In Uganda’s Kasese district, for example, a review of a measles outbreak using 7-1-7 identified shortages of accessible funds, fuel, and vehicles that delayed the response. District leaders established funds they could access quickly. When, a few months later, the Crimean-Congo hemorrhagic fever appeared, the district detected it in three days, notified authorities in one, and mounted an effective response in two. Only one case was confirmed, and the patient survived. Because funds were available before the emergency, authorities were prepared and able to act. This kind of preparation can’t wait until the next crisis begins. Plague is an old disease we that know how to stop. The next threat may be harder to recognize, harder to treat, and easier to spread. Safer labs, less risk of spillover, and faster outbreak detection and response need sustained investment now, while we still have time to prevent the next emergency. Share
Fund Update: 208,165 $IVV shares added to Japan Science & Technology Agency portfolio
Japan Science & Technology Agency has added 208,165 shares of $IVV to their portfolio, per a new SEC 13F filing. This disclosure reflects the funds' holdings for the 09-30-2026 report period. You can see the fund's full portfolio on Quiver Quantitative, and also track the largest institutional owners of $IVV.$IVV Hedge Fund ActivityWe have seen 1,995 institutional investors add shares of $IVV stock to their portfolio, and 1,563 decrease their po
Fund Update: New $130.0M $QQQM stock position opened by Japan Science & Technology Agency
Japan Science & Technology Agency has opened a new $130.0M position in $QQQM, per a new SEC 13F filing. This disclosure reflects the funds' holdings for the 09-30-2026 report period. You can see the fund's full portfolio on Quiver Quantitative, and also track the largest institutional owners of $QQQM.$QQQM Hedge Fund ActivityWe have seen 859 institutional investors add shares of $QQQM stock to their portfolio, and 367 decrease their positions in
Cannabis and Health: How Cannabinoids Affect the Human Body
Dietary cannabinoids such as CBD show anti-inflammatory and immunomodulatory activity in experimental studies, but evidence that supplementation improves human health remains limited.
How payment data connects Dogecoin transactions to business records
From transaction hashes to invoice IDs, payment systems need a way to connect blockchain activity with the commercial records Maryland businesses use every day.
A CDC survey finds 4 in 5 US teenagers fall short of high heart health scores
A CDC study of 5,192 US high school students found that approximately 80% had low or moderate cardiovascular health scores based on five measures assessed in a national survey. Diet, sleep, and physical activity received the least favorable scores, with differences observed across sex, grade, and racial and ethnic groups.
AI study of 101,000 patients links brown fat to heart and mental health
In a retrospective analysis of PET-CT records from 101,243 patients, researchers found that detectable brown fat was associated with lower prevalence of cardiometabolic and psychiatric conditions, while greater activity, particularly in the axillary region, was linked to more favourable metabolic outcomes. Medication screening identified losartan, which increased brown fat thermogenic activity in laboratory experiments and energy expenditure in mice, although its effects on human brown fat remain unproven.
How Badly Does Smoking Wreck Your Reproductive Organs? Here’s What the Science Says.
In a 12-week mouse study, cigarette smoke extract altered ovarian gene activity and changed testicular tissue at higher doses.
Flu activity begins rising in Central California as health officials urge vaccination
New data published by Epic Research reports that flu rates are off to their earliest start post-pandemic.
Cattle futures higher waiting on direct business
At the Chicago Mercantile Exchange, live and feeder cattle were up, optimistic about the week’s direct business. Direct cash cattle trade activity was relatively quiet on Thursday. There was a lone bid that surfaced in Kansas at $226 live, but the rest of cattle country has been quiet. It appears sellers are holding out for […]
Mysterious brain activity under anesthesia challenges what we know about consciousness
Even under general anesthesia, the human brain can analyze language, recognize different types of words, and predict what comes next in a story, according to a surprising discovery by Baylor researchers. The findings challenge our understanding of consciousness and suggest that the unconscious brain is far more capable than scientists previously realized.
Madera Flea Market vendors report sharp drop in business amid fears over ICE activity
Vendors at the Madera Flea Market say business has dropped dramatically in recent weeks as fears surround a reported increase in ICE activity.
Your Business Probably Has More Data Than Insight by Nathan Tayloe
Most businesses know more about themselves than they ever have. Leaders have access to financial reports, sales pipelines, customer data, employee metrics, website analytics, and dashboards for almost every part of the organization. CRMs track every stage of the sales process. Marketing platforms report results in real time. AI can analyze and summarize enormous amounts of information in seconds. Yet I've sat in plenty of meetings where all of that information is available, and some of the most important questions are still surprisingly difficult to answer. What's actually working? Why are customers choosing us? Where are we losing opportunities? What should we do differently? Having the data and understanding what it means are two very different things. More Information Doesn't Always Create More Clarity Over the past decade, businesses have invested heavily in visibility, and that's a good thing. We can understand performance with a level of detail that would have been unimaginable not long ago. But there's an unintended consequence. The easier something becomes to measure, the easier it is to assume it must be important. Website traffic goes up, so that looks positive. Leads increase, so marketing appears to be working. Sales activity climbs, so the pipeline looks healthy. Maybe. The numbers tell us what happened. Understanding why it happened, whether it matters, and what we should do next still requires judgment. Not Everything That Matters Fits on a Dashboard Consider a customer who ultimately contacts your company through Google. The data may attribute that lead to search. What it may not show is that the customer heard about you from a colleague six months earlier, saw your company mentioned in an industry publication, followed one of your employees on LinkedIn, and read several reviews before finally searching for your company. Google may have produced the click. It didn't necessarily create the decision. This happens throughout a business. Some of the things that matter most are difficult to reduce to a single metric: Why your best customers stay Why talented employees choose your company Why a prospect trusts one provider over another Why one service is gaining momentum while another isn't Why the market perceives your business the way it does Data can help answer those questions, but it needs context. Better Decisions Start With Better Questions One of the easiest traps for leaders is starting with the information in front of them rather than the decision they're trying to make. Instead of opening a dashboard and asking, "What does the data show?" it can be more useful to start with a different set of questions: What are we trying to understand? What decision are we trying to make? What would we need to know to make that decision confidently? That changes the role of data. Instead of looking at every number available and searching for meaning, you're using information to understand something specific about the business. Information Still Requires Judgment More sophisticated analytics and AI will continue to give leaders access to better information, faster. That's valuable, but I don't think it reduces the importance of experience and judgment. If anything, it increases it. Someone still has to decide which numbers deserve attention, which patterns matter, what context might be missing, and when the data isn't telling the whole story. The goal isn't to know more about your business simply because you can. It's to understand your business well enough to make better decisions. Good data can tell you what happened. Good leadership has to decide what it means. — Learn more about how we help organizations turn business, customer, and marketing insights into smarter strategies at tayloegray.com, or reach out directly at nathan@tayloegray.com.
Goldman Sachs CEO Solomon on earnings: We have a big, durable, diverse business
CNBC’s Kate Rooney and David Solomon, Goldman Sachs Chairman and CEO, join 'The Exchange' to discuss earnings going forward, M&A activity, and more.
Commonly prescribed blood-pressure drug may stimulate 'healthy' brown fat
Scientists have discovered that the drug losartan, commonly prescribed for high blood pressure, boosts brown adipose tissue activity in mice, enhancing their metabolism. This indicates that repurposing ...
N. Syracuse Manufacturer Marks Milestone, Plans for the Future
Air Innovations has grown from a small local manufacturer into a global business, selling its products in 74 countries organizations. Some of its clients include NASA, Blue Origin and SpaceX. By Stefan Yablonski [caption id=attachment_11117 align=alignright width=450] Michael Wetzel, president and CEO, and his father, Larry, who currently is an adviser to the board of directors. Larry served as the chairman of the board until 2024, when the company was acquired by Altus Capital Partners, a private equity firm.[/caption] Air Innovations in North Syracuse hopes to add more employees and possibly even expand its facility in the near future. The company is a global leader in designing and building environmental process control systems for applications that can’t be addressed with standard HVAC equipment, according to Michael Wetzel, president and CEO. “We customize solutions for temperature, humidity, filtration and pressurization, with additional capabilities in direct-expansion, chilled-water and thermoelectric technologies. Our business now is entirely focused on specialty or niche markets.” Air Innovations celebrated its 40th anniversary on Sept. 18, marking four decades of doing business, manufacturing products and growing in Central New York. In the beginning [caption id=attachment_11138 align=alignright width=451] A worker, Ezzy Salehi, tests a Wine Guardian condenser unit at Air Innovations.[/caption] “A guy by the name of Jim Kelley started the business [known as Floratech] in 1986. It was focused on refrigerated display cases for supermarket fresh flowers,” Wetzel said. “My father [Larry] started Clean Room Technology in the early 1980s, then sold that to a French company called Clestra Cleanroom. “My father and I bought Floratech in 1996 — 30 years ago, 10 years after it was started. Then in 1999, Floratech bought a portion of Clestra and their building. At that point everything was still called Floratech. But, as that was not reflective of the diversity of the business, we rebranded as Air Innovations in 2001.” The company rebranded to pursue a strategy of diversification in specialty HVAC systems. Wetzel explained that since then, it has become a trusted global partner, earning the President’s “E” Award for Exports and securing contracts in the most demanding fields, including aerospace, defense and semiconductor manufacturing. Air Innovations has grown from a small local manufacturer into a global business, selling nearly 70,000 units in 74 countries and territories and developing custom environmental control systems for companies and organizations including NASA, Blue Origin and SpaceX. “We work with all the big names you ever heard of and some you never heard of,” Wetzel added. The Wetzels sold the business two years ago to Altus Capital Partners, a private equity firm focused on control investments in lower middle-market, niche manufacturing companies in North America. Founded in 2003, Altus Capital Partners’ headquarters is in Wilton, Connecticut, with an additional office in Lincolnshire, Illinois. “They are an equity firm. Both my father and I both maintain a small minority share. I am going to continue to be involved. I call myself a part-time CEO. I will continue that role for the foreseeable future; I don’t see any change there.” Building to the future “We are at 58 employees right now, which is a little bit down. We had a high of 70. That moves along with the activity we have,” Wetzel said. “We’ll start ramping up here in the fourth quarter into next year. More than 20% of our employees have been with the company for more than a decade. “I am fairly certain that sometime in the next several years we are going to have to enlarge the footprint of our facility and for sure we are going to have to add employees. We already are. We are probably going to have to add five or six people next year. We are always in the market for HVAC technicians; we always need those.” Air Innovations will remain in Central New York, with its current workforce staying in place, he added. “I believe the primary driver of our success over time is the diversity of our business which is a direct result of our willingness to tackle new challenges,” Wetzel said.
Mom-and-Pop Business Owners Grapple with Harsh Times
Report shows small business owners in NYS less optimistic about the economy. Taxes, inflation, labor costs and competition from larger businesses are major concerns right now, they say By Aaron Gifford [caption id=attachment_11067 align=alignright width=300] Ashley Ranslow is director for New York state at The National Federation of Independent Business (NFIB).[/caption] Owners of mom-and-pop businesses in New York state have been less optimistic lately than their peers in other parts of the country, a recent report indicates. The National Federation of Independent Business (NFIB), based on a survey of 11,000 of its members in the Empire State, reported that taxes, inflation, labor costs and competition from larger businesses are major concerns right now. “Indeed, while taxes are a major problem in New York and the United States overall, New York small businesses notably are struggling more with the state’s onerous, multi-level tax burden,” Ashley Ranslow, NFIB’s director for New York state, said in the July report. Compared with surveys of business owners in other states, far fewer New York respondents rated their businesses as in excellent or good health. The report also said labor costs here are about 25% higher than the national average and are the “single most important problem” facing businesses. One respondent to the New York-specific survey complained that too much red tape, taxes and laws that restrict high-yielding companies have stifled their operation’s growth. Others said high disability and workers’ compensation insurance costs, alarming increases in utility rates and excessive building regulations are discouraging. Statewide, New York has a gross domestic product of $2.53 trillion (third in the nation, followed by Texas, $2.90 trillion; and California, $4.25 trillion), a per capita income of $90,500 (sixth) and an unemployment rate of 4.6% (34th). There are 2.4 million small businesses that employ 3.9 million people. [caption id=attachment_11112 align=alignright width=451] Member of the Greater Liverpool Chamber of Commerce gather at one of the several functions the chamber organizes monthly. “Everyone in this business community encourages each other to shop local. Everyone just wants to see each other succeed,” says Megan Wilmot, the chamber director[/caption] “New York state boasts one of the largest, wealthiest and most diverse cities in the world — and that’s still only about half the state’s population,” the report said. “In other words, the state is both its iconic city and so much more — geographically, demographically, economically. But New York is not without its challenges, challenges that include notably high taxes and other weaknesses that impact the small business environment,” it said. The report includes an optimism index that compares responses from New York (NFIB) members with those of their peers in other states across several categories. This ranges from plans to increase employment to expectations for higher sales, to plans to increase inventory or expand. The scores for Empire State business owners were lower in most categories, but they did score higher than the national average in noting that they have current employment openings, and that they are hopeful that the economy will improve. “The metrics so far paint a picture of a state with a series of challenges for small businesses, from a slightly below national average Optimism Index to a more seriously below national business health to very substantially below national Employment Index. What is going on with businesses that are creating these differences?” the report stated. In Central New York, the regional labor force comprises nearly 398,000 workers. The median household income here is $71,463, and the gross domestic product for the region last year totaled $61.3 billion, according to the CenterState CEO economic development and research organization. About half of the region’s labor force works for small and mid-sized businesses, although the number of people employed in that sector has decreased by 7% since 2010, according to CenterState’s 2026 economic forecast report. “While record-high employment in large-scale enterprises provides a strong foundation for Central New York,” the report says, “the long-term health of communities depends on a thriving small business sector to serve as a stabilizer.” Area employers identify several barriers to Central New York’s anticipated growth, including lack of specialized or skilled workers, government regulations, unaffordable housing options and long-term construction disruptions. In the city of Syracuse, the number of jobs in retail trade decreased by 1,500 or 4.7% between July 2025 and this past July. By contrast, the number of jobs in the leisure and hospitality sector increased by 2.5% or 700 jobs, in the same annual period, according to the New York State Department of Labor. Still, there’s plenty of interest for new businesses across Central New York. U.S. Census figures show that the number of applications for new businesses in all four counties increased significantly in the past 20 years. In Cayuga County, there were 324 applications in 2005 compared to 470 last year. In Madison County, the number increased from 385 to 480; Onondaga County, from 2411 to 4132; and Oswego County, from 553 to 836. Downtown Cazenovia is exemplary of Madison County’s trend: In the past year, the village welcomed a bait shop, a thrift store, a vitamin infusion center, a pizzeria, a Pilates studio and an Italian restaurant. A candy store is scheduled to open on the main drag in the months ahead. Oswego’s list of interesting new businesses in the past year includes a bubble tea shop, a hot dog eatery in Fulton, a specialty grocery store that features New York state products in Mexico, a beauty and esthetics studio in Hannibal and a hardware and farm supply store in Sandy Creek. In Onondaga County, the Liverpool area has also enjoyed a steady stream of new shops and eateries in recent years. That suburban community is unique in that, unlike neighboring communities, most of the restaurants are family-owned and not part of a national chain. [caption id=attachment_11116 align=alignright width=300] Megan Wilmot is the executive director of the Greater Liverpool’s Chamber of Commerce.[/caption] Megan Wilmot, executive director of the Greater Liverpool Chamber of Commerce, said independent business owners in her community maintain a strong sense of pride in holding their own against national companies. The chamber helps boost morale with red carpet events, ribbon cuttings, coffee hours and five-year anniversary celebrations for participating businesses. “We have built such a strong community,” Wilmot said. “Everyone in this business community encourages each other to shop local. Everyone just wants to see each other succeed.” In Syracuse, the downtown retail occupancy rate last year was about 82%, a slight improvement from 2024, according to the Downtown Syracuse Committee’s most recent annual report. Buildings with the largest amount of vacant space included The Galleries, One Park Place, and Equitable Towers, though not all of those spaces are designated for retail use. New businesses that opened in downtown Syracuse last year: Better with Time Clothing, Dakshin Curry & Biriyani, Havana Tattoo Society, Milano Bean Café, Miss Daisy, Pausa Coffee, Sweets for Babe, The Society CNY and Yafah Beauty Studio. The Destiny USA mall’s occupancy rate decreased from 80% in 2023 to 72% by the end of 2024, according to Integra Realty Resources. That leaves more than a quarter of the mall’s retail space vacant. “Looking ahead, the retail market is expected to see minimal rent growth, with vacancy rates likely remaining stable in community and neighborhood centers but continuing to rise in enclosed malls,” Integra’s report said. “New construction activity is low and redevelopment plans for former malls like Shoppingtown and Great Northern are still in the planning stages. The proposed Micron chip plant may spur development, but challenges remain in finding co-developers for large-scale projects.” Nationally, the U.S. Chamber of Commerce expects that small businesses will remain resilient and see their sales and revenues eventually improve. That organization, in a recent national survey, found that 25% of small business owners expect the economy to improve in 2027, while 45% indicated that they plan to increase employment in the next 12 months. And 69% said they believe their small business is in good shape and 70% said they are comfortable with their current cash flow. Thirty-one percent of small businesses reported raising their prices in July and 28% are planning to raise their prices within the next three to four months, the report said. Twelve percent indicated that this is a good time to expand their business. “Small business owners voice optimism for future revenues and hiring,” the report said. “High costs continue to be a wet blanket on reinvestment.” The NFIB reported in July that Main Street, despite gas price hikes, “is OK … for now.” Its small business economics trend report said sales across the country have been strong compared to last year, but continued inflation and higher prices from mom-and-pop establishments are causing some “cracks” to show. “If costs stay this high for much longer, reduced investment will have a tangible economic impact,” the report said. “The status quo is OK, but the outlook? The outlook is uncertain.”
Gaskin: White Stadium could hurt local businesses
White Stadium will create economic activity. The question is whether the surrounding businesses will participate in it — or pay part of the price for making the transportation plan work.
Want to Get More Deep, Restorative Sleep, Starting Tonight? Science Says All It Takes is 10 Minutes a Day
A little more activity can lead to longer periods of restorative sleep.
After surging troops to the border, US Army showcases a quieter Rio Grande
The U.S. Army is deploying hundreds of soldiers to Texas' Rio Grande Valley in response to what it says are signs of elevated activity from Mexican drug cartels.
After surging troops to the border, US Army showcases a quieter Rio Grande
The U.S. Army is deploying hundreds of soldiers to Texas' Rio Grande Valley in response to what it says are signs of elevated activity from Mexican drug cartels.
After surging troops to the border, US Army showcases a quieter Rio Grande
The U.S. Army is deploying hundreds of soldiers to Texas' Rio Grande Valley in response to what it says are signs of elevated activity from Mexican drug cartels.
Spooky Science Event at the Florence Farmers Market
(Mass Appeal) – Are your kiddos looking for a fun, interactive STEM activity that incorporates Halloween? Then we have Spooky Science at the Florence Farmers Market on Wednesday, October 14th from 2:00pm-6:00pm.Here to tell us more is Dr. Megan Allen, Founder & Owner of The Community Classroom Tutoring and Cora Rose Allen-Flynn, Megan’s daughter & […]
Marking World Mental Health Day, ASICS brings movement, mental health conversation to Malibu
The event revealed new global research on declining physical activity and featured a screening of Human Nature, a new short documentary narrated by Sigourney Weaver examining how modern life is quietly designing movement out of everyday life.
People Ate 2 Meals With The Same Calories And Macros. Scientists Watched As 1 Spiked Their Insulin Much More
Ultra-processed food impacts brain activity associated with rewards, as well as our metabolisms.
NCBA Urges Cattle Producers to Document Ranch Business Activity Amid Hobby Loss Rules
In today’s Beef Buzz, senior farm and ranch broadcaster Ron Hays spoke with Kent Bacus of the National Cattlemen’s Beef Association about tax rules that could affect cattle producers, particularly smaller operations that experience multiple years of losses. Bacus explains why keeping accurate records and understanding IRS guidelines are important for protecting family ranches, while
Doctored 2006 front page falsely portrayed as genuine article about Nigerian politician's 'madness'
As political activity intensifies ahead of Nigeria’s January 2027 election, misinformation is circulating online, including a purported 2006 newspaper front page with claims that presidential candidat...
Google Expands Automatic Activity Tracking And Brings Health Guardian To The Fitbit Air
The company announced new health features for its wearables along with a new band for the Fitbit Air.
St. Mary’s and Dean nurses expand labor charges against SSM Health
Nurses at SSM Health St. Mary’s Hospital and Dean Medical Clinic have joined forces to expand labor charges against their parent company, SSM Health, alleging union-busting activity. St. Mary’s nurses filed federal labor charges Sept. 8, nearly two months after voting to unionize under the Service
Why is health-related economic inactivity on the rise?
More people in the UK of working age are leaving the labour force because of poor health than in other similar countries. An effective policy response requires understanding the rise of work-limiting mental health issues among younger workers and musculoskeletal conditions among older workers.
Memorial Health urges early flu shots before season begins
Memorial Health is encouraging central Illinois residents to get flu shots now as influenza activity begins earlier in some regions.
State encourages residents to stay updated on flu, COVID vaccines as virus activity increases
Hawaiʻi Department of Health encourages residents to take common-sense precautions against influenza, COVID-19 and other respiratory viruses as respiratory virus activity increases throughout the state.
Rockstar HR Questioned Over Discord 'Mole' And Sudden Timing Of GTA 6 Dev Firings In Latest Labor Tribunal Hearing
A junior Rockstar employee was leaking trade union activity to management
‘A Latino problem’: National Democrats clash with Andy Beshear over Texas governor’s race
Kentucky Gov. Andy Beshear hoped being chair of the Democratic Governors Association this midterms year would raise his profile and connections ahead of his expected 2028 run for president. But it’s also created an opening to ramp up pressure on him, with frustrations spilling into the open this week as multiple Texas Democratic members of Congress and national group leaders accused him of putting his book tour and potential 2028 activity ahead of helping Democratic nominee Gina Hinojosa win the Texas governor’s race.
18 must-try fall activities in the Seattle area
Here are 18 fall bucket list items in a handy quadrant chart to help you find the perfect activity to do, based on your budget and love of (or aversion
Trail Blazers Should Make Deflections a Public Standard
Portland’s defensive identity hinges on disruptive activity. By tracking deflections, Micah Nori can reward the hustle that rattles opponents, fuels transition opportunities, and proves winning begins off-ball.
Buttigieg joins Ford at Las Vegas business to talk affordability
Nevadans are preparing to vote this fall as campaign activity increases among candidates.
New resolution calls rat problem in Northeast Philly a ‘public health emergency'
A new resolution urges the Health Department and other agencies to coordinate an urgent response to rodent activity in Lower Northeast Philly.
A Fortune 500 media company will use Cyabra to track online manipulation
Cyabra will deploy its platform for marketing, communications and security teams to track campaigns and distinguish organic activity from manipulated content.
Haze not ‘a threat’ to Singapore F1 race, but entertainment could be curbed
Transboundary haze from Indonesian fires has pushed city state’s air quality to unhealthy levels, but track activity will not be affected.
Flu season arrived months early. Get vaccinated now, experts say
Flu activity began rising in September, ahead of its typical early-November start, said Dr. Dawn Terashita with the Los Angeles County Department of Public Health
Singapore Grand Prix entertainment may be curbed if haze worsens, FIA says
There might be "some restrictions" on outdoor activity such as entertainment during this weekend's Singapore Grand Prix, but not on the race, if the haze currently blanketing the city-state worsens, the motor sports governing body said on Thursday.
Motor racing-Singapore Grand Prix entertainment may be curbed if haze worsens, FIA says
By Xinghui Kok SINGAPORE, Oct 8 (Reuters) - There might be some restrictions on outdoor activity such as entertainment during this weekend's Singapore Grand Prix but not on the race, if the haze blanketing the country worsens, the motorsport governing...
Seattle market owners worry ICE activity is hurting business
The owners of Mendoza’s Mexican Mercado, a 15-year staple along Seattle's Aurora Avenue, say sales have dropped 30% compared to last year as fear of U.S. Immigration and Customs Enforcement activity keeps customers away.
Seattle business owner claims ICE activity is hurting sales
Owners of a Seattle Mexican market say they are worried that ICE activity is driving customers away, reporting a plummet in sales and foot traffic.
Chicago business owners push back on proposed ordinance targeting ‘troubled’ businesses
Some aldermen see their ordinance as a potential solution to crack down on criminal activity, and businesses that are accused of enabling criminal activity.
What Amazon's profiles got right and wrong about us
Amazon's "About You" shows customers what it infers from their shopping activity. We asked Business Insider staff to check theirs.
Health records link ADHD to more than fourfold higher risk of later cognitive impairment
A new study led by University of Pittsburgh School of Medicine researchers finds that adults with attention-deficit/hyperactivity disorder (ADHD) face a significantly higher risk of developing dementia ...
Scientists changed how zoo lions eat. Their wild side came out
Giving zoo lions whole carcasses on a feast-and-fast schedule appears to bring out more natural behavior. The lions spent nearly three times longer feeding, engaged in more tearing and manipulating of food, and rested more heavily after meals. Their activity then increased gradually during the fasting period, closely resembling the rhythm seen in wild lions.
Fastest-Ever 'Mind Reading' AI Model Can Reconstruct Images From Your Brain
See what the person saw - and what the AI recreated from their brain activity.
Five Paddock Market businesses ordered to close over unlicensed activity
Several businesses inside Ocala’s Paddock Market have been ordered to close immediately due to unlicensed activity.
Students Use Forensic Science Skills in Escape Room
Hundreds of students from across the region put their problem-solving skills to the test this week during the Regional Science Consortium’s annual Forensic Science Escape Room. Elementary school students had just a few hours to figure out how someone died as part of a forensic science escape room activity. The Regional Science Consortium partnered with Mercyhurst University for the 10th year of the event, which is taking place at the Tom Ridge Environmental Center. It began Monday and runs through Thursday.Throughout the week, more than 250 students are working to solve murder mysteries using real forensic science techniques. Students must analyze the evidence, piece together clues and solve the crime before time runs out.Organizers said the event gives students interested in pursuing forensic science in college a firsthand look at what a career in the field could entail.Sarah Skelton, Special Gifts Coordinator at Iroquois, said the activity provides students with an opportunity to develop skills that can sometimes be difficult to practice in a traditional classroom. "It really helps them to work in teams and on critical thinking skills. Which, not that they don't get these opportunities, but it's hard sometimes in the classroom to develop those higher-level thinking skills”, said Skelton.Students also get a chance to learn how forensic science is used in real-life investigations. As Skelton explained, "What are the real-life applications? What would you actually see in a crime scene? How would you handle these types of forensic investigations? So it's really cool our kids get to see what opportunities are out there and possibly a career field one day."The popular event has grown over the years, with some students returning year after year. Organizers said watching those students grow and develop their interests is one of the highlights of the program.Jeanette Schnars, the Executive Director of the Regional Science Consortium said it's rewarding to see how students' interests evolve as they get older. According to Schnars, "How they have grown and matured and where their interests are going and maybe they aren't going into forensics, but if they are going into sciences or different disciplines, so it's really fulfilling to see how they have matured."One student who continues to enjoy the event is sixth-grader Mia Harvey of Iroquois. Harvey hopes to pursue a career in medicine and says the forensic science activities are helping her explore her interests, "One day I want to become a neurologist, and learning about the bones is probably going to help me."Harvey said her favorite part of the event is the real-life application of what she's learning. "While you are trying to find the clues, they teach real stuff that you would need to know”, said Harvey.Event organizers said if students are learning while having fun, then the program is accomplishing its goal. "Not only are they learning the science, but they are having fun with it too”, said Schnars.Adults will also have a chance to take part in the experience this Saturday during an adult version of the escape room, which will feature food, drinks and entertainment. For more information, click here.The Forensic Science Escape Room has become one of the Regional Science Consortium’s most popular events, with teachers signing up their students as soon as registration opens in August.
Alexandria health officials issue vaccine guidance as respiratory illness season begins
As the season for increased flu and other respiratory illnesses arrives, the Alexandria Health Department is providing guidance on vaccines and other recommendations for residents. Flu season begins in October and continues until May, although activity may peak in the winter months. Other respiratory illnesses such as COVID-19 and RSV (respiratory syncytial virus) also circulate during
Is it possible to preserve your memories before dying? The science is moving beyond science fiction
For most of history, preserving someone’s memories after death meant relying on photographs, letters, stories and the recollections of other people. Technology is now pushing that idea much further. Scientists can record parts of brain activity linked to memory, researchers are mapping the neural networks that store experiences, and digital systems can preserve enormous amounts of a person’s voice, writing, images and personal history. That still falls far short of copying a mind. No technology
Nature recognized as key component of lifestyle medicine and health
The American College of Lifestyle Medicine (ACLM) today welcomed a resolution adopted by the Association of Fish and Wildlife Agencies (AFWA) that recognizes nature's role in supporting human health and calls for greater collaboration among the conservation, healthcare and research communities.
Global experts call for coordinated action on digital health risks
The way digital technologies are currently built and governed creates real risks to health worldwide, alongside genuine benefits, according to a new three paper Series authored by 13 global experts, published in The Lancet.
US says foreign financial institutions doing business with Iran may be sanctioned without notice
WASHINGTON, Oct 5 (Reuters) - The US Treasury Department said on Monday it was alerting foreign financial institutions that continue to do business with Iran or its financial sector that they may be sanctioned by Washington without advance notice. DETAILS: • "Foreign financial institutions continuing to transact with sanctioned Iranian financial institutions could be targeted at any time without advance notification and should take immediate action to terminate such activity and relationship
US services sector activity slows in September; price pressures mount
US services sector activity slowed in September as supply chain strains and rising input prices signal persistent inflation risks into next year.
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Prize in medicine has been awarded to three scientists whose work led to a tool that uses light to help unravel how the brain works
NFIB jobs report shows small business hiring slowed in September
NFIB’s September jobs report shows a decline in hiring activity among small businesses as the labor market continues to soften.
Traders Purchase Large Volume of Call Options on Sphere Entertainment (NYSE:SPHR)
Sphere Entertainment Co. (NYSE:SPHR - Get Free Report) saw unusually large options trading activity on Monday. Traders bought 9,775 call options on the company. This represents an increase of 1,615% compared to the typical volume of 570 call options.
US services sector activity slows in September; price pressures mount
US services sector activity slowed in September, with strong domestic demand stretching supply chains and raising prices paid by businesses for inputs, indicating that inflation could remain high into next year.
Eurozone business activity grows at fastest pace in 41 months in September
Private sector growth accelerates as demand improves, while input costs, selling prices rise at fastest rates since May | Anadolu
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Assembly praised their method, noting its global use in revealing brain mysteries.
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Assembly praised their method, noting its global use in revealing brain mysteries.
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Prize in medicine was awarded Monday to three scientists working on the mechanisms the brain uses to switch on, or off, the activity of individual nerve cells.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel Prize in medicine was awarded Monday to three scientists working on the mechanisms the brain uses to switch on, or off, the activity of individual nerve cells.
Nobel medicine prize goes to 3 scientists for research into brain activity
The Nobel committee lauded their work, writing on X that the method “is now being used in laboratories around the world to reveal the brain’s mysteries.”
Scientists win Nobel medicine prize for research into brain activity
Their work was lauded “for discoveries leading to optogenetics, which makes it possible to switch on, or off, the activity of individual nerve cells in a living brain.”
German and US scientists win Nobel Prize in medicine for research on brain activity
The trio won the award for their discoveries concerning light-gated ion channels and optogenetics. This neurobiology tool has provided new insights into how we might treat blindness, depression, addiction and dementia.
As flu season approaches, here’s why you should you get your vaccine now
While flu activity is still relatively low, officials say now is the time to get vaccinated before cases begin to rise later this year.
Euro zone business growth hits over 3-1/2-year high despite inflation worries, PMI shows
BENGALURU, Oct 5 (Reuters) - Euro zone business activity expanded at its fastest pace in nearly 3-1/2 years in September as demand remained strong despite inflation worries stemming from the Middle East war, according to a private survey which also showed resurgent price pressures.
Euro zone business growth hits over 3-1/2-year high despite inflation worries, PMI shows
By Indradip Ghosh BENGALURU, Oct 5 (Reuters) - Euro zone business activity expanded at its fastest pace in nearly 3-1/2 years in September as demand remained strong despite inflation worries stemming from the Middle East war, according to a private su...