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Former Texans star J.J. Watt officially replaces Tony Romo as CBS Sports' lead NFL analyst
Former Houston Texans star J.J. Watt has signed a multi-year deal to permanently replace Tony Romo as CBS Sports' lead NFL analyst alongside Jim Nantz and Tracy Wolfson.
JJ Watt Named CBS Sports’ New Lead NFL Analyst in Multi-Year Deal
JJ Watt, the former defensive end, will take on one of the biggest on-air roles in sports after officially being named the new lead NFL analyst for CBS Sports, being handed the post following the exit of his predecessor, Tony Romo. Watt will continue to call CBS’ top games alongside Jim Nantz and Tracy Wolfson …
Have your say! Gregor Kobel nominated for special award
Alongside Kobel, Lany Bäcker (SGS Essen), Said El Mala (1. FC Köln), Vanessa Fudalla (Bayer Leverkusen) and Ibrahim Maza (Bayer Leverkusen) are also nominated. Since 2007, the state of North Rhine-W...
Como humiliate Manchester United, Michael Carrick's job on the line
A footballing lesson.Alongside the clash between LOSC and Galatasaray, another hugely important match took place this Wednesday at 18:45. Como hosted a Manchester United side in crisis, who headed int...
Six Flags Sinks 10%, United Parks & Resorts Drops 5%: Is the Goliath Accident Still Weighing on Theme Park Stocks?
A fatal roller coaster accident cast a shadow over one theme park operator, but now a second company with no connection to the ride is getting pulled down alongside it, raising questions about how far the damage spreads through the sector.
Kansas City Chiefs React to Patrick Mahomes’ Career News
The Kansas City Chiefs have another reason to celebrate Patrick Mahomes after the franchise quarterback reached a career milestone that places him alongside one of the NFL’s greatest players. His latest achievement reinforces his remarkable consistency and highlights how quickly he has established himself among the league’s elite signal-callers. Mahomes tied Tom Brady for the […] The post Kansas City Chiefs React to Patrick Mahomes’ Career News appeared first on Gridiron Heroics.
Catching up with sleep health supplements: A roundup of the latest science
Sleep has moved from a lifestyle concern to a core measure of health, as inadequate sleep affects a substantial share of adults and often occurs alongside chronic stress, undermining health, well-being and performance across sleep-wake cycles and life domains.
How Small Pharmacy Expansion Will Impact CVS Health (CVS) Investors
CVS Health has been rolling out smaller pharmacy focused stores, expanding MinuteClinic sites and raising its 2026 revenue and earnings outlook, alongside new efforts in benefit transparency and women’s midlife health research. The push into underserved neighborhoods with compact pharmacies and clinics points to a tighter focus on access, operating efficiency and aligning physical sites with where prescription demand actually shows up. This article examines how CVS Health’s investment...
iPad Mini 8 Expected Next Week With These 10 New Features
Apple reportedly plans to unveil an iPad mini 8 with an OLED display next week, with those invited to Apple's Los Angeles experience on Wednesday, October 28 expected to receive hands-on time with the device, alongside MacBook Pro models with touch-enabled OLED displays, a 14-inch MacBook Pro with an M6 chip, and an iMac with an M6 chip.
Yankees 'balance and lengthen' lineup with this 1 offseason move
The Yankees could use another slugger alongside Aaron Judge.
Hanan Al Kuwari: Executive, Minister, Diplomat - And A Middle-Power Mediator?
The State of Qatar has nominated former minister of public health Dr Hanan Mohamed Al Kuwari for Director-General of the World Health Organization (WHO). Entering a competitive contest alongside six other candidates as the WHO faces financial instability, workforce restructuring, and geopolitical fragmentation, her campaign positions her as a pragmatic, delivery-focused nominee.
Garmin launches Edge 1060 bike computer with voice control, alongside new Edge Explore computers and Tacx Nēra smart trainer
New Edge 1060 heads up trio of new computers and trainer refresh from Garmin
A note to readers: Science, accountability and elections
Dear readers, As early voting begins, I wanted to share some news — and why it connects to the decisions we make at the ballot box. I’ve been selected for the inaugural cohort of the South Atlantic Climate Journalism Hub mentorship program, hosted by Covering Climate Now. I’m excited to join this group, learn from scientists and fellow journalists, and expand my science reporting. Science directly ties to governance. Local officials make decisions about where development goes, how infrastructure is maintained, what emergency preparations receive funding, and how communities rebuild after disasters. Understanding the evidence behind those decisions helps us evaluate whether our government is serving us well. Here in western North Carolina, those connections are all around us, in Lake Lure and beyond. Flood maps inform decisions about property and development. Engineering assessments help identify risks at dams and bridges. Rainfall forecasts guide emergency preparations. Geological information helps explain landslide hazards. Water testing gives communities information they need to assess conditions. Meteorologists’ knowledge and public perception of weather events shape public safety. Each involves scientific or technical knowledge. Each also raises questions about public responsibility: What did officials know? How did they use that information? What did they tell the public? What did taxpayers receive for their money? A study can identify a problem. Elected officials still have to decide what to do about it, how to pay for it, and how to explain their choices. Reporting should examine both the evidence and the response. That is where I want to strengthen my work. My reporting on Helene recovery, infrastructure, flooding, public safety, and public spending has repeatedly brought me to questions that require scientific expertise alongside public records. This mentorship may help me better understand the research, ask more precise questions, and explain the answers clearly. I also bring the perspective of someone living with these concerns. I live downstream of Lake Lure Dam, and landslides affected my property during Helene. Those experiences bring urgency to my questions. Careful reporting helps establish the answers. Readers deserve to know what the evidence shows, where uncertainty remains, and whether officials accurately describe the information guiding their decisions. You also deserve scrutiny of proposed solutions: what they cost, what they are expected to accomplish, and what risks remain. Access to that information matters. As a mostly deaf journalist who relies on written communication, I will continue pressing for written public warnings, records, and explanations that people can read and use in real time. As you consider the candidates seeking your vote, consider how they approach evidence, preparedness, and transparency. Do they support local journalism, even when it’s not parroting a press release? Do they explain weather events clearly in plain English and explain their decisions after them? Make supporting records available? Acknowledge uncertainty? Follow through when a report identifies a risk? Those are practical questions about governing. Thank you for supporting Cops & Congress and the work that makes these questions part of the public conversation. I’m grateful to David Dickson and the CC Now team for this opportunity, and I look forward to bringing what I learn back to you. Annie DanceEditor & Publisher, Cops & Congress — Learn more about this newsletter, ethics policy, how you can help shape this work, and support it. Follow on X and Facebook. Send constructive criticism, fan mail, and tips with public documents for future stories: CopsandCongress@gmail.com ICYMI: View the Cops & Congress archive — Annie Dance is the publisher of Cops & Congress, a newsletter that analyzes what happens when crime, courts, disaster, democracy, and small-town policies collide. Views expressed here are covered by the First Amendment. Dance has a Bachelor of Arts from Manhattan University in Communication with a focus in Journalism and Government. She has been a journalist for over 20 years. Share Upgrade now or give a gift subscription
Roland unveils a new Jupiter-8-inspired Boutique synth in celebration of the original's 45th birthday – and drops an all-new wavetable synth too
A pint-sized take on the '80s classic, the Jupiter-08 launches alongside the N/vision, a wavetable synth that promises "rich tonalities, evolving textures and sophisticated sound design"
An Intro to New Orioles GM Jared Banner
The Baltimore Orioles made a front-office shakeup on Monday, bringing in assistant general manager of the Chicago Cubs, Jared Banner, to become the new general manager alongside President of Baseball Operations Mike Elias. Banner, who served as the Cubs' assistant GM from 2024 to 2026, joined after Elias expressed a desire to add "fresh voices" …
Trump to create new NIH division, task force for women's health
President Donald Trump will sign an executive order alongside first lady Melania Trump on Monday creating a task force and a National Institutes of Health division focused on women's health, the White House said.
Trump to create new NIH division, task force for women's health
WASHINGTON, Oct 19 (Reuters) - US President Donald Trump is expected to sign an executive order alongside first lady Melania Trump on Monday creating a task force and a National Institutes of Health
Clippers rebuild includes developing young core alongside veterans
With the Kawhi Leonard era over and James Harden departed, a healthy Darius Garland will be running point for a team blending youth with veterans.
Voter guide: What to know about candidates for Kansas insurance commissioner
House Speaker Dan Hawkins and Senate Minority Leader Dinah Sykes are running alongside Libertarian nominee Ric Koehn.
How Investors May Respond To Encompass Health (EHC) First Maine Hospital Opening
Encompass Health has opened Encompass Health Rehabilitation Hospital of Bangor, a 50 bed inpatient facility in Maine that delivers intensive therapy, frequent physician oversight and 24 hour nursing for patients recovering from complex conditions across a 54,000 square foot site with a wide range of on campus clinical amenities. This Bangor facility is Encompass Health's first wholly owned hospital in Maine. It adds owned capacity in a new state alongside its existing joint venture presence...
Calgary Flames Make Intriguing Lineup Decisions Ahead Of Hurricanes Clash
The Calgary Flames will face off with the mighty Carolina Hurricanes, and they have made their decision on a starting goaltender.Per Daily Faceoff and Pat Steinberg, Devin Cooley will get the nod when the puck drops between the Flames and Hurricanes. So far, Cooley has struggled alongside most of the Flames. He lost both of […] The post Calgary Flames Make Intriguing Lineup Decisions Ahead Of Hurricanes Clash appeared first on HEAVY.
Castill Health Announces Plans for Philippines Digital Healthcare Launch, Supported by Craig Astill and Caason Group
Singapore, Singapore--(Newsfile Corp. - October 17, 2026) - Singapore-based digital healthcare venture Castill Health has announced plans for its first market rollout in the Philippines, targeted for later in 2026.The company is developing a digital healthcare platform intended to connect wearable health monitoring devices, personal health information and access to participating medical professionals.Australian entrepreneur Craig Astill alongside Caason Group and Castill Family Office, is...
SCIENCE-DINOSAUR
In this illustration, the meat-eating dinosaur Invictibellatrix amberina feeds on a mammal while grasping another alongside other dinosaurs on the Isle of Wight, United Kingdom, in the Cretaceous Period around
Television Q&A: When will 'The Rookie' be back on patrol?
ABC’s “The Rookie” is set to return for a ninth season in 2027, likely in January, alongside new spinoff “The Rookie: North.”
UI receives grant for business student wellness
A multimillion-dollar donation to the University of Iowa’s business college, alongside a matching gift challenge to generate even more funds, will help support a student mental health and success initiative
What Does Hims & Hers Health (HIMS) Expansion Into The UK And Australia Mean?
Hims & Hers Health (NYSE:HIMS) announced the launch of Hers personalised hair loss and wellness care in the UK in October 2026. The Hers UK rollout introduces tailored treatment plans for women's hair loss alongside broader wellness services through the company's telehealth platform. The business is also expanding its Hers care platform into Australia, adding another English speaking market to its international footprint. The Hers UK hair loss launch and Australia expansion open new chapters...
Julia Stiles says she’s been ‘crying’ in “DWTS” rehearsals for Heath Ledger dedication: ‘I didn’t expect it’
Ledger, who starred alongside Stiles in 1999’s “10 Things I Hate About You,” died in 2008 at age 28.
Pokémon TCG Pocket Is Finally Fixing One Of Its Most Frustrating Features
Alongside slowing its release cadence, trading and immersive cards are also getting improvements
Caesars Entertainment (CZR) Following Argus Focus Is The Digital Growth Story Undervalued
Caesars Entertainment (CZR) is back in focus after research provider Argus highlighted its mix of roughly 50 U.S. gaming properties and detailed 2024 EBITDAR contributions from Las Vegas and regional operations. Recent trading has been softer, with the share price slipping over the past week and month, and the 3-month share price return down 2.04%. However, Caesars Entertainment still carries a 24.15% year to date share price gain and a 34.61% 1-year total shareholder return, alongside a much...
Anakin Skywalker actor Jake Lloyd shares rare message to ‘Star Wars’ fans alongside fellow child star from prequels
Jake Lloyd, who starred as Anakin Skywalker in 1999’s ‘The Phantom Menace,’ shares rare message to ‘Star Wars’ fans alongside fellow child star from prequels, Daniel Logan.
Oops, Apple's Website Just Hinted at iPad Mini 8
Apple has an unreleased iPad mini Smart Folio listed on its French regulatory website, hinting that a new iPad mini is coming. The case's A3632 model number doesn't match current or past iPad mini cases. Apple appears to have added the case to its website recently, and it's listed alongside iPhone 18 Pro accessories added in September. The listing doesn't include any iPad mini specs, but it does suggest design changes to the device it's meant for.
New Mid-Market Arts District Launches With $500K Investment From SF Billionaires
SF business leaders and wealthy donors are funding a new Mid-Market arts district, which launches alongside a free festival Saturday, as a growing number of Bay Area artists call for a boycott of events funded by billionaires.
How 'Sunrise on the Reaping' landed its 'dream' cast
With up-and-coming actors working alongside Hollywood veterans in the new "Hunger Games" prequel film, "Sunrise on the Reaping" reflects a "dream" cast for its filmmakers.
Computational Models as Liminal Models in Neuroscience, a Cognitive Science Speaker Series Presentation | Events
Speaker: Danielle Williams, Ph.D. Title: Computational Models as Liminal Models in Neuroscience Short Bio: Danielle is a philosopher of mind and science whose research examines the role of computation in our theories and explanations of the mind and brain. Her work brings together philosophy of mind, cognitive science, neuroscience, and artificial intelligence, with particular interests in computational theories of mind, computational modeling, and the relationship between different explanatory and modeling strategies in the mind sciences. She also investigates philosophical questions raised by contemporary AI, including the nature of opacity in computational models and its implications for explanation in cognitive science. Alongside this work, she is a historian of cognitive science and AI, examining how the development of computer technology has shaped our conceptions and models of the mind and brain. Abstract: Scientists rely on various types of models to make sense of their phenomena of interest. This has led philosophers to take up a range of semantic, ontological, and epistemological questions about how models represent, what kinds of things models are, what we learn from models, and how they explain. One type of model that has been of particular interest to philosophers is the computational model. Computational models are commonplace in the mind sciences in general and neuroscience in particular, with many asking how computational modeling can help us understand the nervous system and its contribution to cognition and behavior. These questions are particularly pressing in neuroscience, as computational models have become a dominant framework for making sense of cognition. Thus, old questions about model-based science have re-emerged within the context of neuroscience, with many philosophers looking to established frameworks to understand how computational models represent, explain, and contribute to theory development in neuroscience. These established frameworks, however, characterize computational models as a homogeneous type which cannot capture actual modeling practices in neuroscience. In this talk, I argue that computational models in neuroscience are best typed as a kind of liminal model, a type I introduce to capture how the status of a computational model is determined by the epistemic context in which it is deployed. Indeed, the category to which a computational model belongs shifts according to the role it plays within a given context. ASL-English interpreters have been requested. Light refreshments will be provided.
Alohi Gilman reflects on playing alongside Chargers QB Justin Herbert
During his press conference, Kansas City Chiefs DB Alohi Gilman reflected on playing alongside Los Angeles Chargers QB Justin Herbert | @EdEastonJr
Gibraltar to Sell Infrastructure Business to Saint-Gobain for $208 Million
Gibraltar Industries (ROCK) has agreed to sell its Infrastructure business, D.S. Brown, to Saint-Gobain for $208 million in cash. The price is subject to customary post-closing adjustments. Closing is expected in the fourth quarter of 2026, subject to closing conditions, including required regulatory approvals.Gibraltar expects the transaction to be highly tax efficient and plans to use the proceeds to accelerate debt reduction as it focuses its portfolio on building products and structures end-markets. Management will update its 2026 outlook for the sale alongside its third-quarter 2026 report; that report’s timing will be announced separately.
Willis Automotive plans ‘business as usual’ following sale
Willis Automotive and the Sewell Family of Companies are forming a new partnership as Willis Chairman Rich Willis sells the company to current CEO Jason Willis and Sewell Family member Collin Sewell. Jason Willis will continue as president and CEO of Willis Automotive, remain an owner alongside Sewell and Rich Willis will retire. The sale…
Ubisoft plans cuts at German studios, adding to wave of workforce reductions
Ubisoft is planning to reduce its workforce in Germany, where it operates a trio of studios, by about 100 workers, Game File has learned. The company wants to offer employees buyouts to, should enough people accept, avoid having to lay anyone off. “In Germany, we initiated discussions with the Works Council last week regarding a proposed voluntary departure plan across Ubisoft Dusseldorf, Ubisoft Berlin & Ubisoft Mainz,” a company rep told Game File. A “works council” is a union-like group representing employees. “The voluntary plan is the primary measure being proposed to support the intended organizational changes,” the Ubisoft rep added. The company declined to confirm the scale of the potential headcount cut. Of the impacted studios, Mainz might be the best known to the public. It leads development of the Anno series and shipped the well-reviewed strategy game Anno 117: Pax Romana in November 2025. Berlin and Dusseldorf operate as support studios within Ubisoft’s creative network. Berlin recently supported the development of Rainbow Six Siege and the Rayman Legends Retold remake. Dusseldorf also contributed to those projects, as well as The Settlers and Ubisoft-branded escape rooms. Dusseldorf is the biggest of the three studios, with some 400+ workers, compared to just over 100 at the other two, a source familiar with the reductions and the teams told Game File. More than half of these new reductions of about 100 people are expected to happen at Dusseldorf. The planned cuts were announced at a town hall for the German studios on Tuesday of last week. In an email follow-up, the studio group’s managing director, Benedikt Grindel, said the cuts were intended to “best position our German studios for the future... with a clearer focus on their role, capabilities and organizational setup needed for the work ahead.” The email was an echo of the past. In January 2025, Grindel had emailed the Ubisoft developers in his region (or studio “zone”) to explain that a round of 185 cuts at the time, including about 65 at Dusseldorf, were “essential to improve our operational efficiency and ensure the long-term sustainability of our studios, the zone and the company.” A half-decade of continued job cuts Ubisoft has been aggressively cutting its headcount for years. At the end of September 2022, it had 20,729 workers. By the end of March 2026, that total was down to 16,590. Studio management is trying to trim costs as it grapples with a changing industry and a drought of releases, let alone hits. The company announced earlier this year that it had reduced its costs since 2022 by “nearly €325 million” ($362m) and planned to lower them through 2028 by another €180 million ($200m). In June the company said it was closing down its Winnipeg and Belgrade studios and cutting roles in its Barcelona team. Even commercial and creative success hasn’t spared studios from this ongoing company-wide contraction. As Game File was nailing down details around the proposed cuts in Germany, Ubisoft management was informing workers of cuts in its Singapore studio, which shipped a hit remake of Assassin’s Creed IV: Black Flag this past July. Some 70 positions in Singapore are being eliminated “to align the studio with upcoming production needs,” per a company rep’s statement to Game File. In early 2024, a large team in the Singapore studio launched the multiplayer pirate game Skull & Bones. It performed poorly but has been supported with regular content updates since. Many of Ubisoft’s studios around the world are heavily subsidized via regional grants and tax breaks. Singapore had been among them for years, but received no such local assistance in the 12 months ending this past March. News of the Singapore cuts broke today alongside word that Ubisoft is also proposing the closure of RedLynx, pending negotiations with officials. The Finnish studio behind the motorbike series Trials was founded in 2000 and sold to Ubisoft in 2011. As reported by VGC (and corroborated by Game File), Ubisoft management told employees it could not come up with a new, sustainable assignment for RedLynx. The 2025 workforce at Ubisoft Dusseldorf were straight-up cuts. This time, Ubisoft is hoping the reductions at its trio of German studios will largely come from workers taking a payout to leave. The company offered such voluntary dismissals at its Massive Entertainment studio (The Division) a year ago. For the German studios’ buyouts this time around, Ubisoft and the Works Council had discussed a formula that’d pay a worker’s monthly salary multiplied by 1.5 and by the number of years they’ve worked at the company, according to Game File sources. The formula is still subject to negotiations with the Works Council and has not yet been part of an official offer to workers. It could be adjusted up or down, and it could be supplemented with additional bonuses. Asked about the floated payout formula, a Ubisoft rep told Game File, “The terms of a potential voluntary departure program remain subject to negotiation with employee representatives. No final agreement has been reached, and we won’t comment on specific proposals while discussions are ongoing.” Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Epic’s AI adventures Epic Games (Fortnite, the Unreal engine) is all-in on using AI to try to transform the way it makes video games and game-making tools. It’s leaders appear to be undeterred by any resistance among gamers and some game developers around generative AI—and instead emboldened by advances, particularly in AI-assisted programming. A recap of the last three days: On Monday, Bloomberg reported that Epic management told workers last week that development of an upcoming game combining Star Wars and Marvel characters would be “AI first.” Employees would be expected to use AI models such as Claude to code the game. A manager told Epic’s developers there would be “[n]o more hand-written code” and that art for the game would be “generated with full AI workflows,” per the outlet. Just ahead of that story running, Epic founder Tim Sweeney tweeted: “We have a huge pivot underway here at Epic, moving developers around to retool for maximum AI acceleration. The aim isn’t to do the same stuff with fewer people, but to enable everyone here to build MORE and BETTER stuff, and to bring the benefits to all teams using Unreal.” In a follow-up, Sweeney predicted that most game development processes would be at least three times faster a year from now than they were in January 2026, thanks to AI. To a person on X who told him he was failing to read the room, Sweeney said: “Much of the room wants it to be 2016 again, but it’s not. Our job, as the provider of tools and technology to much of the industry, is to design for the present that is and the future that will soon be.” On Wednesday, Epic announced it was releasing a faster launcher for its Epic Games Store marketplace. It did so by stating in a blog post as clear as could be that the launcher is an AI-enabled, vibe-coded project: Programming is hard. So, instead of doing that, we vibe coded a new Epic Games Launcher that’s way faster and more responsive than the current one, and has a new look. Programming is hard? That was unexpected phrasing from a company founded by a legendarily great programmer. Back in 2011, Sweeney told me that he’d picked up programming quickly as a kid and rejoiced at the power it gave him. “I could look at any program that anybody else had written and, with enough effort, build something cooler.” Item 3: The Xbox Labs experiment (and one of the people behind it) Microsoft’s Xbox division, which is flooding the zone with announcements lately, yesterday revealed a new internal tech-tinkering team called Xbox Labs. In the words of Xbox boss Asha Sharma Labs is “a small group of game makers, engineers and scientists whose job is to turn emerging ideas into things our players and developers can experience.” Conventional wisdom coming out of the announcement is that Labs is a team that’ll focus on ideas driven by generative AI. In her announcement, Sharma cited some of the dizzying achievements in tech and gaming over the past month as AI agents and other AI tools have been deployed to swiftly figure out how popular games work, then rebuild them and mix them up. She mentioned seeing ”games rapidly decompiled and rebuilt to run on hardware they were never originally designed to support” and said “[p]erhaps more surprisingly, we’ve seen many of the biggest games in the world have been remixed into the source code of another.” (Minecraft plus Elden Ring, for example, or Fortnite + Super Monkey Ball + Overwatch + Diablo + others.) Sharma also cited the work of Windows PC games being ported to run in browsers, a seeming reference to a recent AI-assisted fan port of Halo. Or perhaps Call of Duty or GTA. Sharma didn’t use the specific term “AI” in her memo, but she came close, citing AI “agents” and their potential for game-making tools that Labs could help craft: I think XBOX has an important role to play here. Coding became the first major workload for agents because they can write, run, and test software. Games share many of those same properties, and people spend more than 72 billion hours a year playing XBOX games, roughly five times the estimated time spent writing code worldwide. We’ve spent 25 years learning how to make great games, and I want our game makers to help shape what these new technologies make possible. As we learn, we’ll share the tools we build with developers across the industry, just as we always have. When I asked an Xbox rep if Labs was an AI-centric team, they said genAI was not the focus, describing it as having a broader mandate for using new tech in new ways in gaming. As an example, they pointed to Xbox’s recently launched disc-to-digital gaming usage rights program. Microsoft didn’t specifically name anyone involved full-time in Xbox Labs yesterday, but on social media and LinkedIn, I spotted Adrian Mato IDing himself as leading the creatio of tools at Labs and talking up the launch. Mato first caught my attention in late September, when he said on X that he was “starting to build a new team at Xbox focused on products and tools for how games get built and distributed as agentic tools become more capable.” At the time, he framed AI-based tools as a supplement to traditional game dev tools. “I don’t think we need to replace them,” he said. Since then, he’s publicly shown interest in AI and in games. He’s recently spent some of his X feed marveling at the power of AI agents and praising the lighting in the latest Gears of War. Following the Labs announcement yesterday, he enthused about the Xbox Labs’ stylish landing page. He wrote: “We built some fun tools to art-direct shaders in real time, experimented with interactive ASCII art, and sprinkled in lots of tiny details. “Move your mouse to leave a colorful trail that reveals the original footage, or interact with the video to trigger bursts of particles. “A lot of love went into making it all feel just right. “More to come”
Aaron Paul Pays Tribute to RJ Mitte, Advocates for Mental Health: ‘I’m So Sorry You Were Hurting’
Aaron Paul posted a video of his "Breaking Bad" co-star RJ Mitte advocating for mental health alongside a moving tribute following his death earlier this week.
Zero Escape And Hundred Line Director's New Game Canceled Before He Could Announce New Studio
Kotaro Uchikoshi planned to announce new studio Crash Keys alongside its first game
Giants Should Target This Starter to Pair With Logan Webb
The San Francisco Giants could unleash a groundball revolution by signing this veteran right-hander. His elite sinker offers the perfect high-impact complement to stabilize the Giants' inconsistent starting rotation alongside Logan Webb.
Small business optimism dips as labor shortages persist
Expansion plans lessened alongside expectations for business conditions, labor quality and inflation remain top concerns.
Kansas City Royals news: 2026 “odd” from BWJ?
The Kansas City Royals winter wait continues, alongside 25 other clubs.
Letters: Cutting city health budget in half jeopardizes vulnerable residents
As president and CEO of the Louisiana Public Health Institute, my job is to understand what helps our communities become healthier and to work alongside partners who share that commitment.
Samsung Health Makes Sleep Coaching Easier to Start and Tailors Weekly Guidance
Sleep Coaching starts with three days of data and adjusts weekly, while Running Coach introduces advanced training and Scan Meal debuts in U.S. beta alongside personalized nutrition guidance
iOS 27.2 adds new app icon for Apple Music, more design updates
iOS 27.2 beta 4 debuted today for developers, and the update includes a new app icon for Apple Music alongside other design updates.
Apple's HomePod mini 2 is here with Siri AI, new colors and improved sound
The smart speaker is priced at $149. Alongside the new Apple HomeView, upgraded Apple TV 4K, and Apple Home Collection, the company also unveiled the...
Microsoft Fixes 1,118 Vulnerabilities in October Patch Tuesday and Introduces New Risk Cohorts
Microsoft’s October 2026 Patch Tuesday briefing outlines 1,118 vulnerabilities across 15 risk groups, alongside a new approach designed to help security teams review large update releases.
Samsung’s first Android XR glasses leak in 25 styles alongside 9-hour battery, specs [Gallery]
Samsung’s first Android XR glasses are right around the corner and, ahead of launch, another leak reveals every style you’ll...
Updated HomePod mini 2 comes with new colors and surround sound option
Apple has unveiled its first-ever update to the HomePod mini, concentrating on how it can be part of a smart home setup alongside devices like the Apple TV 4K.
Soule favored to start alongside Dybala and Malen vs Real
Gian Piero Gasperini won’t limit the quality of his players out of fear of Real Madrid. Los Blancos have a team of phenomenal players, but the Giallorossi coach has no intention of focusing solely o...
Peoria bagel business one of eight to attend New York Growth Lab
A Peoria bagel business will soon stand alongside other up-and-coming concepts in New York as part of BagelUp's second annual Growth Lab.
Breaking the stigma: Rome conference highlights Catholic mental health ministry
A Rome conference highlighted Catholic mental health ministry, urging the Church to break stigma and offer spiritual support alongside care.
I built a family business from scratch to $200 million. Now I’ve become its bottleneck
The hardest thing to accept is that people who didn’t build this company alongside you can see things you don’t.
Apple's all-new HomeView smart home hub leaked ahead of tomorrow's event — alongside new Apple 4K TV and HomePod mini 2
We know what Apple is about to reveal
Jackie Chan, 72, makes first public appearance in months — fans say the same thing
Jackie Chan made a rare public outing on October 9 at the NBA Global Games in China alongside David Beckham, take a look…
How Egyptian femtech is tackling taboos around women's health
Cultural taboos and a lack of understanding can be a barrier for women to access healthcare in Egypt, alongside the cost of treatment. But the country's budding femtech sector is creating new pathways…
Rumor: Apple to Announce New Partnership With ADT
Apple may be planning to announce a new partnership with home security company ADT, alongside the introduction of its all-new smart home hub, according to several clues. Apple has invited the media to a "Welcome home" experience in New York on Tuesday, October 13, so the partnership could be made official on that day. Since around July, ADT has posted "Low Voltage Technician" job listings in various U.S.
Neuralign and Global Ambassador Mandi Gosling Bring Neurological Readiness™ to Science Summit Alongside UNGA
Canadian women-founded Neuralign highlights how Neurological Readiness™ builds foundations for reading, learning and lifelong confidence.
Weekend Reading on Women's Representation: Arizona Congress Candidate Speaks Out About Her Rape, 'It’s OK to Talk About It’: Will Alexandria Ocasio-Cortez Run for President?
Weekend Reading on Women’s Representation is a compilation of stories about women’s representation in politics, on boards, in sports and entertainment, in judicial offices and in the private sector in the U.S. and around the world—with a little gardening and goodwill mixed in for refreshment! —Friday, Oct. 9, marked 115 years since the men of California went to the polls to decide whether the women they lived alongside would be permitted to join them there. —Bernadette Greene-Placentia, the Democratic nominee in Arizona’s 8th Congressional District with a real chance to upset her opponent, was reportedly raped while fixing one of her yard signs. "She chose to share her story because she knows many survivors struggle in silence, and she hopes that by speaking about her experience, others will know they are not alone," said a campaign spokesperson. —Pew Charitable Trust reports that 37 percent of Americans now believe a woman will not be elected president in their lifetime. I urge women like AOC to seriously consider a presidential bid in 2028. —The poet, essayist and translator Anne Carson was awarded the Nobel Prize in literature for her genre-defying work. Since 1901, the Nobel Prize in literature has been awarded 122 times to 104 men and just 18 women. ... and more.
Novi Pet Expo brings animals, adoptions, entertainment to Vibe Credit Union Showplace
The Novi Pet Expo is running alongside the Novi Home Show at the Vibe Credit Union Showplace through Sunday.
🚨 Augsburg-Bayern XIs: Saibari starts; Gnabry on the bench!
Augsburg and Bayern kick off Saturday's Bundesliga action, alongside other matches. The Bavarians want to capitalize on Borussia Dortmund's slip-up after they drew with Werder Bremen on Friday despite...
IRRR, AEOA celebrate 1,000 small business grants
The Ely Echo weekly newspaper and its companion pieces - North Country SAVER and North Country ANGLER - provide insight into the news and happenings of northern Minnesota, alongside the Canadian border. www.elyecho.com
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Gears of War: E-Day sells 230K copies
Gears of War: E-Day has sold 230K copies since its advance-access launch on October 1 and full release on October 6. Steam accounts for 168K of those, with Xbox (console and PC) selling 62K. But there’s more to this story, as Xbox makes up the bulk of revenue. E-Day is the best-reviewed Gears game in nearly two decades (and the best one ever made, in my opinion). The Coalition has made a banger here (it’s currently in my top 10 of the year). Despite E-Day’s undeniable quality, this is a soft result. And it’s down to the business model, really. E-Day has made $37M so far, thanks to the Premium upgrade On Xbox, Game Pass is cannibalising much of the premium revenue. Our estimates show that 1.7M folks accessed E-Day via their subscription rather than a copy. But Xbox is having it both ways – or having it halfway, at least – via its Premium Edition Game Pass upgrade. Game Pass subscribers could pay $30 (or their local equivalent) for up to five days of early access starting October 1. Our estimates show that of the 1.7M who accessed E-Day through Game Pass, 722K paid for the upgrade. Between the review embargo lifting on October 1 and the full release, E-Day managed to shift another 250K early-access upgrades – no doubt helped by the campaign’s rave reviews. So despite selling far fewer copies on Steam, Xbox accounts for almost three-quarters of the revenue (roughly $26M of the $37M, versus about $11M on Steam). So “230K copies” undersells the paying audience. Including the 722K upgrades, nearly 950K people actually paid something for E-Day. The $30 upgrade is a halfstep from cannibalisation, but will Xbox go all the way? While E-Day is a sublime game, these are soft numbers for a flagship when Xbox badly needs revenue wins. E-Day sold 62K copies on Xbox against 722K Premium upgrades, so for every one copy sold on Xbox, nearly 12 Game Pass upgrades were sold. The $70 premium SKU is – functionally – dead on Xbox. Normally you can’t see what a Game Pass player would have paid, because the game’s just there in the subscription. But the $30 early-access upgrade estimate shows that 722K people demonstrated they’ll spend real money on this game. In a world without day-one Game Pass, many of these folks would have bought E-Day at $70. They paid $30 for five days early access to something they don’t own. Xbox is, in effect, charging its most valuable customers the least, based on a hangover from a tried-and-exhausted strategy from a previous administration. Those 722K willing-to-pay players generated about $21.7M via the upgrade. If three quarters of this group – mostly US and European audiences – bought E-Day outright, that’s nearly $40M. Of course, Game Pass does bring in meaningful recurring revenue, and E-Day is adding value for hundreds of thousands of subscribers. However, Game Pass is no longer growing, so Xbox is at a crossroads. Xbox is reportedly looking to do a Netflix and bolt on an ad-supported tier to pad it further. But that will just set a new floor, and leadership keeps telling us the priority now is revenue growth, which is subscriber-speak for ARPU. Xbox has already pulled Call of Duty from day-one Game Pass after day-one inclusion hammered its sales, with new CoD titles now arriving on the service around a year late. We know that some Microsoft executives believe the service devalues games outright, and rumours (which Microsoft has dismissed so far, to be fair) suggest that day-one releases could be taken off Game Pass. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe When a game this well-reviewed does this softly on its home platform, the model – not the game – gets brought into question. What else E-Day’s early adopters have played (including this month so far) Looking at E-Day‘s players on Xbox, most have played the franchise before (86% have played Gears 5, 76% Gears 4), and every game on the crossover list is either a shooter or a title from an Xbox-owned studio (though Game Pass is inflating those numbers, of course, more on that later): As for what else Xbox’s E-Day players have played this month, the top three are Fortnite (16%), Roblox (7%), and Call of Duty (6%). Another 5% played Minecraft Dungeons II, which is also on Game Pass and launched a couple of days before Gears‘ advance-access date. Many Game Pass players are happy to check out most big new additions. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Over on Steam, the top crossover games are also mostly shooters (slightly more PC-coded ones), including Space Marine 2, which was itself heavily inspired by Gears: Looking at what E-Day‘s Steam players are into this month shows who they are – as subscriptions don’t skew the data. The top three are Wardogs (13%), Deadlock (12%), and CS2 (10%), so you’ve got the restless shooter crowd checking out the new hotness. A little further down are Helldivers 2 and Space Marine 2, your co-op PVE shooter players who’ll feel right at home in Horde mode. Game Pass is skewing the playtime distribution on Xbox Looking at the playtime distribution in our platform, E-Day players on Steam are – relatively speaking – playing for longer: 54% of E-Day players on Xbox have played for five hours or less (versus 32% on Steam) 19% of Xbox players played for over 15 hours (versus 33% on Steam) 14% of Xbox players played for over 20 hours (22% on Steam) The absolute number of people playing for over 15, 20, and 50 hours is, of course, bigger on Xbox, thanks to the sheer volume of folks who came in through Game Pass (upgraders included). None of that is cause for alarm. Game Pass is the reason Xbox playtime skews lower, as when a game is free to try, people try it and bounce without putting in even an hour (17% under an hour on Xbox versus 6% on Steam). Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe The subscription brings in tourists alongside the committed, dragging down the average even when the game is excellent (but also perhaps winning over the uninitiated). It’s standard across every subscription-included title, on PS Plus too. Forza Horizon 6, for instance, had 11% of its Xbox players bounce under an hour, versus just 2% on Steam. So, Xbox’s crossroads So there we have it. Gears of War: E-Day is an incredible game whose revenues have been stifled by subscription inclusion and exclusivity. It’s the best-reviewed entry in the series in fifteen-odd years, but it still turned into one of the year’s softer flagship launches, not because players didn’t want it, but because Xbox’s own storefront gave its most willing buyers a reason not to pay. Which leaves Xbox at a crossroads. Will it keep making Gears games when the financial returns are this thin and the margins this low? And if it does, does the next one arrive off Game Pass at day one – the way CoD now does, or even on PlayStation? I think it should. Alright, back to E-Day for me! The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
David Eichenthal
David Eichenthal joins HR&A Advisors as a Senior Advisor with more than three decades of experience in and alongside government.
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Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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