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16 celebrity couples you had no idea dated
Celebrity romances rarely stay secret, but some manage to fly under the radar. Revisit 16 surprising Hollywood couples, from forgotten flings to relationships you never knew existed.
Fremantle Global Entertainment Exec Chris O’Dell Retires After 19 Years At ‘Got Talent’ Maker
Chris O’Dell, one of Fremantle’s longest-serving entertainment execs, is retiring from the Got Talent and X Factor company. He has been at RTL-owned Fremantle since 2007 and left just shy of 20 years ...
Fred VanVleet Rests and Marcus Smart Gets the Keys Over Reed Sheppard
Ime Udoka prioritizes veteran stability as Houston manages Fred VanVleet’s recovery. Defensive stalwart Marcus Smart takes the starting reins during back-to-backs, keeping rookie Reed Sheppard in a reserve role.
Another limited practice for KC Concepcion
Browns WR KC Concepcion a limited participant Thursday because of two injuries
Mark Andrews posts another full practice
Ravens TE Mark Andrews a full participant for second straight day
This Is Carolina: Self-taught mechanic with Autism takes his business on the road
A Myrtle Beach man with autism who taught himself auto repair is launching a mobile mechanic business with his father.
Chicago business leaders push back against mayor's revived head tax proposal
Under the plan, a company with 500 employees would pay $150,000 per year - a cost Johnson described as "a drop in their ocean of resources."
John Fisher Hints at A's New Pitching Direction
At Taylor Smith's introductory press conference, A's owner John Fisher spoke about developing pitchers rather than relying on free agents.
DOJ charges 15 for $2 billion in fraudulent health care claims in California
The largest of the cases involved $1.6 billion in billings for what the DOJ described as “sham substance abuse treatment” in Southern California.
Why Giants Should Part Ways With Adrian Houser
The San Francisco Giants are on the hook to pay Adrian Houser more money in 2027, but his production does not justify it.
Minnesota-Iowa score predictions from Bring Me The Sports staff
The Gophers face one of their toughest tests of the season this week against Iowa.
Disgraced eMudhra drops out of TLS business following certificate debacle
Flubbed key signing "ceremony" allowed minting of Web credentials for any site.
This New Device ‘Bricks’ Your Phone When You Enter Your Bedroom
If you struggle with doomscrolling when you should be sleeping, this new Brick could help.
Josh Simmons set to miss at least four weeks
Chiefs OT Josh Simmons moved to the Reserve/Injured list but will not need back surgery
How well have past GOTY winners sold?
We’re less than two months away from 2026’s The Game Awards, and what a year it’s been for fantastic games, including Resident Evil Requiem, Forza Horizon 6, Slay the Spire II, the Blood of Dawnwalker, and Control Resonant – just to name a few. So as we approach the end of the year, we thought we’d look back on our estimates for the GOTY winners of the past four years. In terms of revenue, Elden Ring (2022 winner), Baldur’s Gate 3 (2023), Astro Bot (2024), and Expedition 33 (2025) have generated a combined $3.8B via 73M copies sold: Let’s have a look, then. Elden Ring has generated $2B in revenue Elden Ring is a phenomenon in every sense. It’s sold a whopping 36.4M copies across Steam (50%), PS5 (35%), and Xbox (15% across console and PC). Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Elden Ring also just passed an astronomical milestone: $2B in revenue. While PlayStation and Xbox account for half of Elden Ring’s copies sold across these three platforms, they account for 57.5% of revenue. This – as ever – is due to regional pricing and the higher relative share of PC gamers in lower-priced markets. For example, around 17.4% of Elden Ring’s Steam copies sold were in China, where the game costs about 26% less than the price in the States. There’s an … interesting narrative going around these days that console gamers are only interested in ball-and-gun games and have the patience for little else. Well, Elden Ring’s impressive sales prove that is simply not true, and across all platforms. What’s more, over 9.8M people have played Elden Ring for over 100 hours, with nearly 3.5M people getting all of the achievements and trophies. For reference, 10.9% of Elden Ring’s PlayStation players have the platinum trophy, while 10.5% of players on Steam and 3.9% of Xbox players unlocked all the achievements. Git gud, Xbox players! Of the 1.5M people who played Elden Ring on PlayStation last month, 4% also played Dark Souls 3 last month, 4% played Bloodborne, and 3% played Sekiro. There’s those Soulsborne diehards for you. By many accounts, including my own, Elden Ring is one of the best games of all time. It’s an evergreen seller that will continue to be a cash cow for Bandai and FromSoftware for years to come. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Elden Ring has sold another 2M copies across Steam, PlayStation, and Xbox this year, generating almost $110M. This means it’s outperforming many of this year’s high-profile releases. Even Elden Ring’s standalone run-based PvE spinoff, 2025’s Nightreign, has sold 7.8M copies and generated $282M in revenue. Baldur’s Gate 3 is another billion-dollar-plus banger Another cross-platform phenomenon is Baldur’s Gate 3, which has sold 23.2M copies and generated over $1.2B in revenue. About 18.7M of these copies (80.6%) are via Steam, 2.9M via PS5 (12.7%), and 1.6M (6.8%) via Xbox. Around 1.3M folks on Steam bought BG3 before it hit 1.0. The PlayStation version launched about a month after the PC 1.0 release, while the Xbox version came four months later due to technical issues around developing local co-op on the Series S. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Across platforms, Baldur’s Gate 3’s monthly active users have never dropped below 2M, including 2.2M MAUs last month (68.5% on Steam, 21.9% on PS5, and 9.6% on Xbox). And it still regularly brings in 280K to 400K players every day: About 1% of BG3’s Steam player base has played for over 500 hours! That’s a little under 200K people. Astro Bot is also an evergreen seller, albeit a more niche, family one Astro Bot, 2024’s winner, has now sold 4.7M copies and generated $291M in revenue. The budget, including marketing, is almost certainly under $100M, given the small Japan-based core team and three-year dev timeline. You can really see why the tides are changing toward less expensive hubs. Astro Bot is the only first-party winner on this list, but follows other first-party winners of The Last of Us Part II (2020’s winner), God of War (2018), and Breath of the Wild (2017). Around 46.6% of Astro Bot’s copies sold have been physical, which is far higher than the typical game. This makes sense for a couple of reasons: There’s a large family audience for this one, and physical boxes are an item to wrap when giving Astro as a gift. Astro has collector value for the PlayStation core (this is nostalgia-fueled platformer celebrating PlayStation’s history) Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Astro is another one of those games that continues selling over time, regularly selling more than 100K a month. It’s sold around 1M more copies this year ($60M in revenue) and is a popular title with families. We can see this using the Alinea platform’s MAU crossover tool: Astro Bot’s top #2, #3, and #4 games by crossover in any given month this year are Minecraft, Fortnite, and Roblox – without fail. The #1 title every month, though, is Astro’s Playroom, a pack-in with all PS5 consoles. For every month this year, between 20% and 30% of Astro Bot players also played Astro’s Playroom that month. So the free pack-in is a noice funnel for converting players to a full paid product. Expedition 33 sells 8.7M despite Game Pass cannibalisation Finally, we have last year’s winner – Expedition 33. The turn-based-RPG banger has generated $366M via 8.7M copies sold, with 58.8% on Steam, 35.7% on PS5, and 5.5% on Xbox. Xbox’s share of copies sold is this low due to Expedition 33 launching on Game Pass, where 4.3M people across console and PC accessed the game. A little under 700K Xbox players used their subscription to play Expedition 33 this year. That said, the game’s 1.5-year Game Pass deal ended last week on October 16, and we’re already beginning to see a positive trend on Expedition 33’s copies sold via Xbox (but the jury’s still out!). There’s understandably a lot of French pride behind this one, as France is the game’s #3 market on both Steam and PlayStation. Vive la France! One thing that stood out to me is that the GOTY winners aren’t $300M Hollywood productions made in the US. They’re mostly mid-budget studios outside the traditional AAA cost centres. Lots to think about there. Also, good games sell well; who’d have thunk it!? And there’s a whole load of them this year, with GTA 6 still to come, too. GTA just made the cutoff point for the VGAs this year. What a coincidence! Loading... Cool links and other stuff Our physical games newsletter from Tuesday was picked up by GameSpot, Eurogamer, TweakTown, and a bunch of others. We’re offering a free trial of our platform for games companies. Send us a message here, or reply right here on Substack/email, and we’ll set you up. Next week, we’ve got some exciting news regarding the future of our newsletter, so stay tuned! The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. Want to see why these companies (and many others) are subscribed to Alinea? Get a free platform trial! [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
As Trump's support slips, white evangelicals remain his Republican bedrock
Polling and interviews show they remain his most reliable constituency
Judge directs President Trump to sit for deposition in his $10 billion lawsuit against the BBC
Trump had agreed to sit for a deposition on Oct. 16, but it was cancelled for what was described as a “matter of national importance.”
‘Carrie’ season 2 renewed after Mike Flanagan teased 3-season plan
‘Carrie’ season 2 is officially a go after Mike Flanagan teased a 3-season plan for his adaptation of the famed Stephen King novel.
Saints power rankings entering Week 7
Saints win, but how much did it change in their rankings?
Tom Brady’s unexpected comment sparks reaction on Fox
OSCAR GONZALEZ FUENTES/Shutterstock.com Tom Brady makes unusual FOX comment Former NFL quarterback Tom Brady used an unusual expression while analyzing Chicago Bears quarterback Caleb Williams during FOX’s October 18, 2026, broadcast. The moment occurred during Chicago’s game against the Atlanta Falcons. Brady described a Williams pass using the word “gyrating,” prompting a surprised response from…
Elanco Animal Health Appoints Jamie Preston as Chief People Officer
Elanco Animal Health Incorporated (NYSE: ELAN) today announced the appointment of Jamie Preston as Executive Vice President and Chief People Officer, effective November 3rd. Preston's appointment follows an extensive and competitive search as part of the company's commitment to attract, develop and retain an engaged global workforce while embedding inclusion, well-being and purpose into daily operations. Preston succeeds Dave Kinard, who intends to retire at the end of the year. Kinard will work
iPhone Duo 2 Prototypes Include Under-Display Face ID
Apple's second-generation iPhone Duo could gain Face ID, with prototypes already incorporating the technology beneath the outer display, according to Bloomberg's Mark Gurman. In the latest episode of his "Power On" podcast, Gurman described Apple's work on adding facial authentication technology to its foldable iPhone. The company is said to be testing the hardware for a successor expected next fall, but has not finalized whether the feature will ship.
Which college football team is the biggest disappointment of 2026?
Some of college football's biggest preseason contenders have stumbled ... hard. From Texas to Texas A&M and beyond, we want fans to name the biggest disappointment of 2026.
Entertainment
Cumberland Theatre will present “The Pillowman,” an award-winning psychological thriller by Martin McDonagh, through Oct. 25. Directed by Nick Hrutkey, the production features Pierce Bunch, Aaron Civello, Brian Records, and
Purdue leaders connect with NYC alumni to discuss the future of business
Two hundred New York City-based Purdue alumni and friends gathered Oct. 13 for a reception at the New York Athletic Club overlooking Central Park. Dubbed “Boilermakers in the Big Apple…
New unit aims to fill gaps in mental health care for NC youth in juvenile detention
The 10-bed unit will provide intensive treatment to young people with acute behavioral health needs who struggle to find placement in other facilities.
Macron needs to start doing his job, political commentator says
Political commentator Joe Sweeny discusses the riots sweeping France and the legal situation facing Rep. Ilhan Omar, D-Minn., on ‘Fox News @ Night.’
Klobuchar, Demuth tangle over what they’ve done in politics, what they would do as governor
A probable final debate in Minnesota’s race for governor had Democrat Amy Klobuchar and Republican Lisa Demuth scrutinizing the records and plans of the other.
Airbnb cracks down on checkout chore lists as hosts face new limits
Airbnb's new checkout rules bar hosts from asking guests to strip beds, wash dishes or do laundry, but some reasonable requests are still allowed.
Patrick Mahomes practicing Wednesday
Kansas City Chiefs QB Patrick Mahomes logs full practice Wednesday
Area establishments announce Halloween entertainment
IRON MOUNTAIN — Halloween is the perfect excuse to dress up, dance the night away and enjoy some spooky-season fun. Area establishments are embracing the holiday with a lineup of Halloween-themed entertainment. — Lakeside Bed & Breakfast of Florence, Wis., will host “Murder at the Costume Ball” on Friday and Saturday, featuring a four-course dinner, […]
Bills Defender Sounds Off on Early Defensive Troubles
Christian Benford addresses Buffalo’s bottom-tier statistical ranking, citing scheme adjustments and roster turnover as the secondary works to mirror Josh Allen’s elite offensive production during a 5-1 start.
Brian Robinson Jr. listed as limited
Falcons RB Brian Robinson Jr. limited with hamstring injury in first practice of week
Paul George Makes Celtics History With Record Breaking Debut
Paul George wasted little time making history with the Boston Celtics, delivering a spectacular performance in his first game with the franchise. Despite Boston suffering a 121-113 loss to the Detroit Pistons on Tuesday night, George gave Celtics fans plenty of reasons to be excited about what he could bring to the team this season.…
Mark Andrews fully practices Wednesday
Ravens TE Mark Andrews a full participant in first practice of week
What Pharmacists Should Know About Sea Buckthorn for Respiratory Health
Sea buckthorn is a commonly used herbal for respiratory health—US pharmacists are knowledgeable in educating patients on herbals, especially during the cold season.
Does Blade Tidwell Have a Future With the Giants?
San Francisco Giants right-hander Blade Tidwell saw an increase in opportunities in 2026, but has he done enough to be a part of the team's future plans?
Bryce Young a full participant Wednesday
Panthers QB Bryce Young off to good start to week with a full practice
CTC’s Fall Variety Show promises an evening of entertainment!
KILLEEN, Texas (FOX 44) – Central Texas College’s Fine Arts Department is inviting the community to celebrate the season with its annual Fall Variety Show! This is a showcase of student talent featuri...
iPhone Duo's Hidden FaceTime Camera Takes 'Trash' Photos
The iPhone Duo's inner screen has an under-display front camera that's largely hidden from view. It's the first time we've seen an under-display camera on an iPhone, and it turns out there's a reason Apple hasn't used the technology before. Apple said the camera offers 1080p video recording, but didn't mention photo quality. Gizmodo said it's a 4-megapixel camera and described the photos as "low-res, washed out, and just not sharp at all".
'Nobody knows what to do': How Long COVID left Physics Girl searching for answers
San Diego's Dianna Cowern, also known as Physics Girl, was one of the internet's most popular science communicators. Long COVID left her bedbound and facing a medical mystery with life-and-death stakes.
Meta ordered to pay New Mexico $25 billion over Cambridge Analytica breach
A judge has ordered Meta to pay New Mexico $25 billion after a jury found the company liable for deceiving users about privacy and content moderation on Facebook.
Trump’s Odd Interaction Sparks Fresh Health Concerns
The president is facing fresh concerns about his health after he made a peculiar move.
🎟️ Y! Sports Biz: One ticket to disappointment, please
Tickets are in the spotlight, from high prices to golden tickets tarnished.
Why an Oregon high school football player was ejected from rivalry game before kickoff
Video shows the player violently shove an opposing player who was running onto the field carrying the American flag.
Your 2026 NFL Week 7 announcing schedule
The NFL will have its first-ever regular-season game in Paris in Week 7, even amid the civil unrest in France. Dave Pasch, Jason Kelce, and Kurt Warner will return to their international booth duties (after Bob Wischusen and Louis Riddick stepped in for Week 7) to call the Pittsburgh Steelers-New Orleans Saints game for NFL…
SSM Health unveils Fond du Lac clinic lobby upgrades
SSM Health added self-service check-in kiosks and other lobby upgrades at its Fond du Lac Regional Clinic.
Dear Abby | Husband's interest wanes after wife's surgeries
Dear Abby: I have been married to my husband for many years. We are both over 60. About eight years ago, I was diagnosed with, had surgery for and rehabbed
Abbott Plans to Separate Nutrition Business Into Publicly Traded Company by End of 2027
Abbott Laboratories (NYSE:ABT) has announced plans to spin off its Nutrition division into a separate publicly traded company, with the transaction expected to be completed by the end of 2027, subject to regulatory and corporate approvals. The proposed separation would create an independent business focused on nutritional products while allowing Abbott to concentrate on its medical devices, diagnostics and established pharmaceuticals operations.
James Harden Identifies Cavaliers’ Biggest Priority Entering His 18th Season
James Harden enters his 18th NBA season still chasing a title and says Cleveland’s biggest priority is staying healthy and trending up.
Mass casualty drill to test San Antonio-area hospitals, EMS response
FACT FOCUS: When it comes to Trump's economy, these are the numbers that matter before Nov. 3
President Donald Trump is trying to convince voters before the Nov. 3 midterm elections that the U.S. economy is rocketing upward.
Reggie Burrows Hodges remixes the Old Masters for an L.A. homecoming
Reggie Burrows Hodges is the subject of three concurrent L.A. exhibitions at the Getty, the California African American Museum and Art + Practice. These will mark his first-ever solo presentations in his hometown.
The Quiet Deadline Addition for the Rockies
The Colorado Rockies made several moves at the trade deadline as their rebuild continues. The pitching prospects the Rockies received in return rightfully got most of the headlines, as several of them landed in the Rockies' top 30. But a quiet addition to the Victor Vodnik trade with the Miami Marlins, infielder Connor Norby, became …
“We were told…”: Why Dortmund stars fled before showering
After their narrow 2–1 win over Azerbaijani champions FK Sabah, Borussia Dortmund’s players left the Olympic Stadium in Baku without showering. The immediate departure on the BVB team bus was appa...
New Bedford youth to choose local health grant winners
New Bedford youth will decide which organizations receive up to $355,000 in grants to improve local health.
LeBron James' 76ers beat Knicks on NBA opening night
LeBron James scores 14 points on debut for the Philadelphia 76ers as they defeat champions the New York Knicks on the opening night of the NBA season.
SLR Business Credit Provides $9MM Senior Secured Factoring Facility to Bedding Company
SLR Business Credit (SLRBC) funded a $9 million recourse factoring facility, supported by accounts receivable and inventory, to Purecare, a 25-year-old,
25% Of Middle Schoolers Proficient In ELA, Science; 18% In Math
According to a recent presentation by district leaders, who described those numbers as “steady progress” and a small improvement from previous years.
Political newcomers De La Cruz and Garcia battle for redrawn Texas 35th Congressional District
On Nov. 3, Texas voters will choose a new U.S. representative for the newly redrawn 35th Congressional District. On the ballot are Republican Carlos De La Cruz and Democrat Johnny Garcia.
A massive asteroid slammed into the North Sea and unleashed a 330-foot tsunami
A decades-long mystery beneath the North Sea has finally been solved. Scientists have confirmed that the Silverpit Crater, buried 700 meters below the seabed, was created when a 160-meter-wide asteroid struck Earth roughly 43 to 46 million years ago. The violent collision blasted a towering curtain of rock and water 1.5 kilometers into the air and triggered a tsunami more than 100 meters high.
Ebola in Kenya: Is it under control as nine cases confirmed?
The US has advised its citizens to reconsider travelling to Kenya but the government tries to reassure people.
AMC Entertainment Holdings (AMC) Shares Climbed, What Is Driving Attention Now?
AMC Entertainment Holdings (AMC) reported a strong Q2 earnings surprise, with revenue up 14.2% year on year and the stock climbing 48.7% since the report. AMC Entertainment Holdings has leaned into this momentum, with a 30-day share price return of 14.07% and a 90-day move of 36.89%, supported by the recent debt refinancing and the launch of its AMC Movie Trivia Game Show mobile app. The year-to-date share price return of 91.30% contrasts sharply with a 3-year total shareholder return that...
Private contractors are set to cash in as millions of Americans lose health care
Implementing Trump’s "big, beautiful" Medicaid cuts will be a windfall for firms like Deloitte.
The Low Block, Week 9: Confusion and frustration
Not feeling very free in the midst of this fall.
Health professionals prepare for 2026 flu season
Medical professionals say it’s not too late to stop the spread. For the past few weeks, local health organizations have hosted clinics urging people to get their flu shots.
Alexander County Veterans Service Officer Cherry Kilby published in NC Medical Journal
Alexander County Veterans Service Officer Cherry Kilby has been recognized for her contributions to rural veterans’ health with the publication of her article, “The Quiet Crisis: A Call for Community-Embedded Solutions for Rural Veterans,” in the Fall 2026 issue of the North Carolina Medical Journal (NCMJ). The article appears in the journal’s special issue, “North […]
Orange County Public Schools rejects salary and health insurance recommendations
OCPS said declining enrollment and what it described as insufficient state funding have put additional pressure on its budget
Christina Applegate Revealed A Shock Health Update After Her MS Diagnosis
Christina Applegate, who was diagnosed with multiple sclerosis in 2021, shared some details after a monthslong hospital stay.
Voters in pre-election poll mixed on state of Massachusetts
Many respondents to a new poll believe Massachusetts has become a worse place to live over the past four years and they still favor keeping incumbent Gov. Maura Healey in
UW Health's East Madison Hospital unveils $140 million expansion
Additions include six new operating rooms, bringing the hospital’s total to 20 operating rooms. There will also be increased surgical prep and recovery bay capacity — increasing from 23 to 60. Inpatient beds are increasing from 84 to 98.
McLellan Sets the Tone as Red Wings Head West
The Red Wings head out for four straight with the Dylan Larkin question still unresolved. #RedWings
Steelers rookie Germie Bernard nominated for NFL award
Pittsburgh Steelers rookie wide receiver Germie Bernard was nominated for the FedEx Air & Ground Player of the Week for his historic performance in Sunday’s overtime win over the Tampa Bay Buccaneers.
New 6-bedroom house tops sales report at $2.4M
Here’s a look at the top 10 home sales for the week of Sept. 28 in Minnehaha and Lincoln counties.
Scientists finally uncover why statins can cause muscle pain
Scientists have uncovered a surprising reason why statins, the widely prescribed cholesterol-lowering drugs that help prevent heart attacks and strokes, can sometimes cause muscle pain, weakness, and even severe muscle damage. Using advanced imaging technology, researchers discovered that statins can attach to a crucial protein in muscle cells and force open a channel that normally controls calcium flow. This causes calcium to leak continuously, potentially damaging muscle tissue.
The Bears’ Missing Piece May Have Just Moved Within Reach
The Bears have found ways to survive a depleted defensive front. Now Ryan Poles should explore adding someone who could […]
How Much Of Cisco Stock's Rise Did The Business Earn?
Cisco Systems (CSCO) supplies businesses and the hyperscalers building AI infrastructure with networking and security products, along with services. The company's stock climbed 92% between late July 2021 and mid-October 2026, before dividends. A rally of that magnitude makes it natural to credit a growing business. So take a guess: how much of that rise came from Cisco selling more.
As Hollywood implodes, is success still possible for a striving actor?
Last year 34-year-old actor Katie Folger moved from Austin into a Silver Lake casita to pursue her acting dream. Now she's performing a one-woman show called "Getting in Bed With the Pizza Man" at Elysian Theater. But will the TV pilot sell?
November 2026: Science history from 50, 100 and 150 years ago
In 1926 we wrote about how there was a good chance Mars had both plants and animals. And in 1876 we probed the duplicity of the artificial butter business
Baptist to add 40 beds, PAM Health to build new rehab hospital
Baptist and PAM Health are partnering to add 40 acute care beds and build a new 60-bed rehabilitation hospital to meet growing regional demand.
Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)
New-to-science seahorse is one of three long-misidentified species
Scientists have identified a new-to-science seahorse species from the Indian waters, which has helped resolve the taxonomy of a group misidentified for over a century. In 1856, zoologist Johann Jakob Kaup described the thorny or spiny seahorse, Hippocampus histrix, based on samples from Japan. Since then, this seahorse has been thought to be a single, […]
Former Chiefs Starting QB Could Help Eagles Replace Jalen Hurts
Former Kansas City Chiefs quarterback Gardner Minshew could help the Philadelphia Eagles after a season-ending setback for Jalen Hurts. The post Former Chiefs Starting QB Could Help Eagles Replace Jalen Hurts appeared first on HEAVY.
Rangers Find Their Offensive Rhythm In Win Over Ducks
The New York Rangers’ offense came alive on Monday night at Madison Square Garden, en route to a decisive 5-2 victory over the Anaheim Ducks.
UFC 333 Embedded, Episode 1: 'I just take their zeros'
The first episode of UFC 333 Embedded was released on Monday.
WATCH: Jupiter defeats Palm Beach Central in key district clash
Jupiter took down Palm Beach Central in an important district game, continued from Friday's lightning suspension. The Warriors now control their district destiny.
Ryan Reaves Pulls Curtain Back On Time With Maple Leafs
Former Toronto Maple Leafs enforcer Ryan Reaves announced his retirement from the NHL last month, ending his career that spanned 16 total season and multiple clubs, including a stop with the Maple Leafs.Reaves, who accumulated over 1,000 penalty minutes during his career, is now pulling the curtain back on his time while with the Maple […] The post Ryan Reaves Pulls Curtain Back On Time With Maple Leafs appeared first on HEAVY.
AI-generated political ads are showing up on TV screens, experts say they are getting harder to spot
Bills OL Bonded Over Fish Tacos During West Coast Trip
Between victories in Los Angeles and Las Vegas, Buffalo’s front line traded turf for Newport Beach, forging championship-caliber chemistry over seaside dinners and Pacific Ocean swims.
‘Over $25,000’ in damage: Bellevue honey business devastated by historic flooding
In Bellevue, September's floodwaters washed away 35 beehives — and with them, years of work
Symposium highlights MIT’s wide range of innovations for aging brain health
In six talks, researchers from across MIT described Aging Brain Initiative projects aimed at advancing the understanding of and interventions against neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS.
Was Miami’s Win Over Florida State RIGGED?
Miami escaped Florida State with a controversial double-overtime victory, but questionable officiating has fans accusing the ACC of protecting its top team. Did Florida State just get absolutely ROBBED against Miami? The Hurricanes escaped Saturday night’s rivalry matchup with a 43-35 double-overtime victory, keeping their undefeated season alive. However, the biggest storyline wasn’t Miami’s performance.…
Virginia home prices climb despite rising inventory
The number of homes for sale climbed across Northern and Central Virginia and Hampton Roads in September, while inventory rose.
Giannoulias opens big lead in Chicago mayoral poll as Johnson loses support
The secretary of state leads in first- and second-choice preferences, while just a quarter of Brandon Johnson's 2023 voters say they'd support him again.
Marine Science Center Releases 6 Rehabbed Sea Turtles
Six sea turtles were recently released in Volusia County after being rehabilitated at the Marine Science Center in Ponce Inlet. All of the turtles were juvenile green sea turtles. The release …
Researchers Discover a Blood-Pressure Drug May Stimulate “Healthy” Brown Fat
Losartan, a drug commonly prescribed for high blood pressure, boosts brown adipose tissue or “brown fat” activity and enhances its metabolism, according to a preclinical study by Weill Cornell Medicine, Rockefeller University and Memorial Sloan Kettering Cancer Center researchers.
Yankees 2026 Roster Report Cards: David Bednar
The Yankees’ closer gave the team a reliable stopper in the ninth for a first time in a while.
Ex-ESPN Star David Pollack Shares ‘Stunning’ Health Update About Wife’s Brain Tumor
'Thank you for faithfully praying!'