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ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Photographer and medical professionals connect science and art during panel discussion

In 2020, the world was put on hold because COVID-19 began claiming the lives of people all over the globe. When a vaccination for the illness was finally made public in 2021, being vaccinated became highly politicized. Instead of focusing on the emotional reactions that people had toward the vaccine, artist Linda Alterwitz was more...

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Oct 25 • 12:14 PM EDT • Science • thesunflower.com
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Mbappé: “This was a team win”

Real Madrid star Kylian Mbappé talked to Real MadridTV after Los Blancos conquered the Camp Nou with a 1-2 victory where he scored both of the team’s goals. “It is a team victory. The protagonist of the match is the team and the group because we knew we had to play a strong game, but […]

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Oct 26 • 4:47 AM EDT • Sports • sports.yahoo.com
Capcom Confirms Data Breach That Affected 11.7 Million Users

Capcom ID is still available to use, but users may see more phishing scam emails.

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Oct 24 • 12:40 PM EDT • Technology • engadget.com
New evidence suggests spinosaurus spent most of its life underwater

Millions of years after animals first conquered land, some took an extraordinary evolutionary U-turn and returned to the water. Using machine learning and thousands of fossil measurements, Yale scientists have uncovered surprising clues about which prehistoric creatures truly became aquatic. Their findings suggest that Spinosaurus spent most of its life underwater, while some ancient marine reptiles previously thought to be fully aquatic actually spent considerable time on land.

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Oct 24 • 8:00 PM EDT • Science • sciencedaily.com
‘Plans to die in office': Bay Area congressman's ex-aides protest challenger's ads

Seven former staffers of Rep. Mike Thompson demand that challenger Eric Jones' campaign remove a commercial targeting the North Bay legislator.

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Oct 25 • 9:35 PM EDT • Politics • yahoo.com
He left the CDC to fight RFK Jr. But was it better to fight from within?

Demetre Daskalakis, CDC’s top immunization official, resigned in 2025 to protest Health Secretary Robert F. Kennedy Jr., then became one of his loudest critics.

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Oct 25 • 5:00 AM EDT • Health • washingtonpost.com
Obama, in Ohio, assails 'cruelty' from Trump in campaign

Former President Barack Obama has stepped into one of America's ugliest midterm fights as he works to rally Democratic voters in battleground Ohio.

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Oct 24 • 5:15 PM EDT • Politics • journalgazette.net
🚨 Barça's squad to face Real Madrid

Barcelona have just announced Hansi Flick's squad for tonight's Clásico against Real Madrid at the Spotify Camp Nou. Midfielder Orian Goren is the standout inclusion in Flick's 23-man squad. Reserve-...

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Oct 25 • 8:26 AM EDT • Sports • sports.yahoo.com
Cam Skattebo Update: Will Giants Star RB Play Against Texans?

New York Giants share news on RB Cam Skattebo after benching in Week 6. The post Cam Skattebo Update: Will Giants Star RB Play Against Texans? appeared first on HEAVY.

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Oct 25 • 11:18 AM EDT • Sports • sports.yahoo.com
Unlocking the mystery behind election polling

Political polling has been a staple of election season for hundreds of years. But recently, a lot of polls have missed the mark — widely. We take a look at how polling is done in Florida.

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Oct 26 • 5:05 AM EDT • Politics • wusf.org
How data centers became a bipartisan political issue in Wisconsin

Data centers are a big issue across the country. As midterms approach, many look to the swing state of Wisconsin for lessons for how that issue could play out nationally.

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Oct 24 • 5:20 PM EDT • Politics • npr.org
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iPhone Duo Fails JerryRigEverything's Dusty Durability Test

Apple's iPhone Duo has failed JerryRigEverything's latest durability test. Despite its IP68 dust-resistance rating, dust entered the hinge through several ingress points, overwhelming the magnets that hold the phone shut. The bend test then left a permanent green line across the inner display, before the screen became unresponsive.

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Oct 24 • 2:27 PM EDT • Technology • macrumors.com
Vivek Ramaswamy campaign switches to shorter version of attack ad featuring Amy Acton’s estranged mother

The ad has sparked bipartisan backlash for Republican Vivek Ramaswamy in his campaign for Ohio governor against Democrat Amy Acton.

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Oct 24 • 9:13 AM EDT • Politics • nbcnews.com
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Here's how Bengals' second half vs Ravens made NFL history

The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.

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Oct 25 • 4:49 PM EDT • Sports • sports.yahoo.com
She voted for Trump every time. Then came cancer and the bills

Cindy Banda faces mounting medical bills after battling breast cancer. Despite the single mother's positive outlook, the financial strain combined with the high cost of living is overwhelming. And it's

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Oct 25 • 8:34 AM EDT • Politics • lancasteronline.com
Exclusive-US Political Candidates Tailor Messages for AI Models Used by Voters

By Mike Stone WASHINGTON, Oct 26 (Reuters) - US political candidates have been engineering their campaign messages to appeal to the AI chatbots ⁠that ⁠more voters have been using to answer questions about issues, and ⁠documents seen by Reuters have revealed some of their strategies. One Powerpoint ...

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Oct 26 • 6:04 AM EDT • Politics • usnews.com
Trump’s D.C. hotel is gone. Mar-a-Lago is now a GOP campaign cash magnet.

Republican campaigns, party committees and PACs have spent nearly $3 million at Trump businesses since his return to office, a Post analysis finds.

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Oct 26 • 6:00 AM EDT • Politics • washingtonpost.com
Marijuana legalization tied to rise in heart hospitalizations, study finds

A study of 50 million hospital records found heart-related admissions rose faster after recreational marijuana sales became legal in 13 Western states.

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Oct 24 • 3:34 PM EDT • Health • usatoday.com
Amendment 87 can help support Colorado health care; no to tax increases; and more (Letters)

Amendment 87 gives Colorado a way to respond to our health care affordability crisis. New income tax revenue would be set aside for health care, K-12 public schools, and early child care, with an annual independent audit. For 97% of…

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Oct 25 • 6:00 AM EDT • Health • dailycamera.com
Cameron Boozer Update: Rolling Right Along

It’s still early, but Cameron Boozer is quickly establishing himself in the NBA

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Oct 26 • 6:45 AM EDT • Sports • sports.yahoo.com
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At Keene State, politics remains a touchy subject for students ahead of Election Day

Students say, while they care about politics, they don’t always feel comfortable discussing the subject with peers on campus.

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Oct 26 • 5:06 AM EDT • Politics • nhpr.org
LSU’s Project Wellness Club provides students with resources for mental, physical health

The LSU Project Wellness Club hosted pumpkin painting and spooky movie night on Thursday, which was just one of the many events the club puts on for students to de-stress and have an on campus outlet. The club focuses on students’ mental health. Co-president and psychology senior Lindsey Puente describes the club as collaborative, saying...

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Oct 26 • 6:00 AM EDT • Health • lsureveille.com
Serbia's political veteran Vucic outplayed all opponents. Then the students came

Serbia’s populist leader Aleksandar Vucic has dominated politics in the Balkan country for 14 years. Then came the students. The former authoritarian president on Sunday the conceded defeat of his

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Oct 26 • 6:10 AM EDT • Politics • 2news.com
Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign

Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.

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Oct 25 • 10:35 AM EDT • Politics • pbs.org
‘Optimus Prime: Awakening’ review: Peter Cullen delivers an emotional performance | Texas A&M University-San Antonio

“Optimus Prime: Awakening” is a 12-minute short film that was screened alongside the 40th anniversary theatrical re-release of “The Transformers: The Movie.” Released in 1986 after the first two seasons of the animated series, “The Transformers: The Movie” returned to theaters in 2026 as part of Hasbro’s yearlong “Apology Tour.” The marketing campaign celebrated the...

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Oct 24 • 4:42 PM EDT • Entertainment • mesquite-news.com
‘Things are really booming’: FAMU homecoming brings business opportunities for local vendors

Florida A&M University (FAMU) homecoming is bringing crowds and business opportunities to vendors selling food, clothing, art and accessories along Perry Street and around campus.

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Oct 24 • 1:04 PM EDT • Business • wctv.tv
AOC tests her progressive message. The results could help shape her future

Alexandria Ocasio-Cortez is drawing big crowds as she campaigns for progressive Democrats before the Nov. 3 election.

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Oct 24 • 9:41 AM EDT • Politics • apnews.com
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Knox County Candidates File Final Campaign Reports Before Election

Maine Republican Party Contributes to Nicole Kalloch's state Senate bid.

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Oct 26 • 4:00 AM EDT • Politics • midcoastvillager.com
‘Resident Evil’ film resurrects horror game franchise

The first “Resident Evil” game came out in 1996, and since then, the franchise has been working to bring zombies, creatures and deadly outbreaks to life. For the newest piece,

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Oct 26 • 1:00 AM EDT • Entertainment • valpotorch.com
Alaska Democratic Senate candidate Mary Peltola and her family suffer minor injuries in car crash

Alaska’s Democratic Senate candidate Mary Peltola and her family suffered minor injuries Saturday in a car crash while driving to a campaign stop, her campaign said.

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Oct 25 • 2:30 PM EDT • Politics • news4jax.com
9 Cool Camping Features Built Into Oliver Travel Trailers (And 3 You Can Add Yourself)

The utility you can get with an Oliver Travel Trailer these days will surely enhance your next camping trip, but there is even more than meets the eye.

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Oct 25 • 10:30 AM EDT • Technology • slashgear.com
Zelenskyy says Starlink is working again in Ukraine

Zelenskyy's comments came after a chaotic 10-day period when connection speeds for Starlink were throttled in Ukraine.

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Oct 24 • 12:15 PM EDT • Business • businessinsider.com
Local business expert recommends reporting scams via BBB scam tracker

The Better Business Bureau warned the public about phishing scams and advised consumers to regularly check their bank and credit card statements to identify fraudulent activity.

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Oct 25 • 8:08 PM EDT • Business • yahoo.com
IU Health’s new downtown medical campus has a name and an opening date

By Daniel Bradley | Indianapolis Business Journal

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Oct 25 • 9:30 AM EDT • Health • dailyjournal.net
Local business expert recommends reporting scams via BBB scam tracker

The Better Business Bureau warned the public about phishing scams and advised consumers to regularly check their bank and credit card statements to identify fraudulent activity.

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Oct 25 • 8:08 PM EDT • Business • fourstateshomepage.com
AOC can draw a crowd. The midterms will test whether her politics can win before 2028

Alexandria Ocasio-Cortez is drawing big crowds as she campaigns for progressive Democrats before the Nov. 3 election.

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Oct 24 • 9:41 AM EDT • Politics • clickorlando.com
Yankees Social Media Spotlight: The MA kids head to MSG

Cam Schlittler and Ben Rice head to Madison Square Garden to watch the Knicks raise a banner.

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Oct 25 • 4:00 PM EDT • Sports • sports.yahoo.com
South Texas Health System (@stxhealthsystem)

2 likes, 1 comments - stxhealthsystem on October 25, 2026: "One Last Chance to Think Pink: Breast cancer remains the most common cancer among women after skin cancer, making routine screenings and early detection more important than ever. Mammograms can help identify breast cancer before symptoms appear, when treatment options may be most effective. Last week, South Texas Health System McAllen celebrated breast health and preventive care with a special Mammo Monday event featuring the vibrant sounds of mariachi music at the hospital’s main entrance. The celebration reflected STHS' ongoing commitment to encouraging women to prioritize their health through regular screenings. Now, there’s one final Mammo Monday remaining! Join us at STHS ER Mission on October 26 from 8 a.m. to 5 p.m. for the last breast cancer event of 2026. During the event, attendees can: 🎀 Learn about breast cancer screening options 🎀 Schedule a mammogram appointment 🎀 Receive a complimentary goodie bag while supplies last To help make preventive care more accessible, South Texas Health System is also offering reduced self-pay rates* throughout October: • 2D Mammogram: $100 • 3D Mammogram: $155 • Bone Density Screening: $160 A screening today could make all the difference tomorrow. Make your health a priority and encourage the women you love to do the same. For breast health resources and information on the Think Pink campaign, visit the link in our bio. *If not already a covered benefit of your insurance.".

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Oct 25 • 7:41 AM EDT • Health • instagram.com
Obama compares Trump's White House renovations to 'Saddam Hussein opening a Cheesecake Factory' at Ohio rally

Barack Obama compared Trump's White House renovations to a Cheesecake Factory run by Saddam Hussein at a Cleveland rally for Ohio Democrats.

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Oct 24 • 6:30 PM EDT • Politics • foxnews.com
Trump started a trade war with Canada. GOP candidates became casualties.

High tariffs on Canadian goods have turned into a liability for Republicans in key midterm races, particularly those in northern border states.

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Oct 25 • 5:00 AM EDT • Politics • washingtonpost.com
Warren, Steelers stiff-arm Saints for 16-10 Paris win

Jaylen Warren had another big day and the Pittsburgh Steelers overcame some red-zone inefficiency to beat the New Orleans Saints.

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Oct 25 • 12:42 PM EDT • Sports • sports.yahoo.com
Trump campaigns in Michigan one day after Obama rallied against him

President Donald Trump will campaign for nominee Mike Rogers in Michigan, a day after former President Barack Obama criticized his administration in the state. Follow for live updates.

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Oct 25 • 8:30 AM EDT • Politics • cnn.com
UCF outlasts No. 2 BYU in 2OT, notches first top-5 win in program history: 'That's the weirdest end of a game I've ever seen'

Scott Frost's Knights came out on top of a doozy.

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Oct 24 • 7:57 PM EDT • Sports • sports.yahoo.com
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Lt. Gov. Juliana Stratton campaigns in Quincy, touts health care plan

Lt. Gov. Juliana Stratton spoke to the crowd about health care and the cost of living for Americans. She said her campaign funding will not come from larger corporations.

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Oct 24 • 3:35 PM EDT • Health • wgem.com
Hochul, Blakeman hit the campaign trail as early voting begins

Both Kathy Hochul and Bruce Blakeman’s campaigns are escalating their attacks over affordability and the governor's record.

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Oct 25 • 6:00 AM EDT • Politics • spectrumlocalnews.com
13 Practical Tools You Should Carry For Fall Camping

Autumn is a glorious time to get the max use out of your camping gear. These tools will supplement your summer kit for an enhanced fall experience.

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Oct 25 • 8:30 PM EDT • Technology • slashgear.com
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race

President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day.

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Oct 25 • 8:27 AM EDT • Politics • news4jax.com
Free walk-in vaccinations return to Yale Health as flu season looms

More than 3,600 flu and COVID-19 vaccine doses have been administered to Yale students this fall, as Yale Health continues its annual vaccination campaign ahead of the winter respiratory illness season.

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Oct 26 • 12:28 AM EDT • Health • yaledailynews.com
Trump escalates rhetoric against El-Sayed as he tries to undermine Democrat in Michigan Senate race

The Republican president has been attacking El-Sayed's faith throughout the campaign and claiming his past statements and background show a sympathy for extremists.

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Oct 25 • 5:50 PM EDT • Politics • pbs.org
Is Lions coach Dan Campbell taking too many risks?

The Detroit Lions are winning football games, but should Dan Campbell tone down the gambling?

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Oct 26 • 6:00 AM EDT • Sports • sports.yahoo.com
Updated cast makes ‘The Social Reckoning’ shine

On Oct. 9, “The Social Reckoning” came out in theaters, which is a follow-up to the 2010 film “The Social Network.” Both films catalog events in the life of Facebook,

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Oct 26 • 1:00 AM EDT • Entertainment • valpotorch.com
Frisco Muslims vote in Texas midterms marked by anti-Islam rhetoric

Texas politicians have campaigned on banning Shariah this cycle. Muslim voters are encouraging their fellow believers to get involved in politics.

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Oct 25 • 4:02 PM EDT • Politics • dallasnews.com
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Why partisan politics may be changing people's accents

With the midterms fast approaching, communicating just the right message has been top of mind on all sides of the political aisle

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Oct 25 • 6:00 AM EDT • Politics • scientificamerican.com
AOC can draw a crowd. The midterms will test whether her politics can win before 2028

Alexandria Ocasio-Cortez is drawing big crowds as she campaigns for progressive Democrats before the Nov. 3 election. Supporters have packed rooms and chanted her name during appearances that have taken

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Oct 24 • 9:41 AM EDT • Politics • kdhnews.com
Shapiro Brings Campaign Tour to State College

Gov. Josh Shapiro brought his campaign bus tour to State College on Sunday evening, speaking alongside local Democrats nine days before Election Day.

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Oct 26 • 12:37 AM EDT • Entertainment • statecollege.com
What Chelsea Did Wrong vs Tottenham

After a stellar run following the international break, things came crashing down for Chelsea as they lost 2-0 to Tottenham Hotspur at the weekend. This marked an extremely rare defeat at Stamford Bridge to the Lilywhites, a crack in a strong record of home wins that has left fans reeling. In this, we will be …

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Oct 25 • 10:54 AM EDT • Sports • sports.yahoo.com
LETTER TO THE EDITOR: Misleading political mailer is a smear campaign

The recent misleading smear mailer by the opponents of Denise Krause in the Oregon Senate campaign is the most disgusting exhibit of money and indecency used to capture uninformed voters’ […]

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Oct 25 • 10:00 AM EDT • Politics • rv-times.com
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race

President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day.

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Oct 25 • 8:27 AM EDT • Politics • wsls.com
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JJ Redick gives updates on Cameron Carr and Adou Thiero

Are Cameron Carr and Adou Thiero getting closer to returning for the Lakers?

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Oct 26 • 1:08 AM EDT • Sports • sports.yahoo.com
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He Took Big Risks to Make Billions. He Wants Georgia Voters to Bet on Him.

Rick Jackson’s run for governor as a political nobody was his latest gamble. The campaign has brought scrutiny to the businesses that made him a fortune.

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Oct 25 • 5:00 AM EDT • Politics • nytimes.com
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit

As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...

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Oct 25 • 11:08 AM EDT • Politics • yahoo.com
Nicki Minaj pledges to support Donald Trump again during Michigan Republican campaign rally

Nicki Minaj told President Donald Trump she would support him forever at a Michigan rally backing Mike Rogers and John James in the midterms.

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Oct 26 • 2:39 AM EDT • Politics • foxnews.com
What happened to the cast of ‘I Dream of Jeannie’? See the stars more than 55 years later

‘I Dream of Jeannie’ paired Barbara Eden’s genie with Larry Hagman’s astronaut for five seasons of magic. See what became of the cast more than 55 years after the final episode.

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Oct 25 • 8:00 AM EDT • Entertainment • ew.com
Josh Pate makes surprising Ohio State College Football Playoff admission

Ohio State is 6-1, 4-0 in the Big Ten, ranked No. 3 and coming off a 19-15 win at Indiana last Saturday that snapped the Hoosiers’ 22-game winning streak. Its only loss came at Texas in Week 2, a result that has aged poorly since the Longhorns lost back-to-back games to unranked Oklahoma and Florida. […] The post Josh Pate makes surprising Ohio State College Football Playoff admission appeared first on Gridiron Heroics.

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Oct 24 • 11:54 AM EDT • Sports • sports.yahoo.com
Jennings: Ramaswamy’s campaign tactics ‘worst politics you could imagine’

Republican commentator Scott Jennings took a swipe at Ohio gubernatorial candidate Vivek Ramaswamy (R) for using a controversial campaign ad featuring his opponent’s estranged mother. The ad, which…

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Oct 24 • 8:57 AM EDT • Politics • thehill.com
Cam Skattebo confirms injury after Giants beat Texans in overtime

Cam Skattebo confirmed he did suffer an injury on his 42-yard overtime run.

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Oct 25 • 5:23 PM EDT • Sports • sports.yahoo.com
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Harold Fannin Jr. erupts for season-high 91 yards in Week 7

Harold Fannin Jr. came on late in Week 7, tallying six catches on nine targets for a season-high 91 yards against Tennessee.

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Oct 25 • 10:36 PM EDT • Sports • sports.yahoo.com
An Iowa Republican’s Unusual Connection to the Kochs (and Kansas)

In his campaign for governor, Zach Lahn has pitched himself as a self-made businessman. His backstory is more complicated.

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Oct 25 • 5:00 AM EDT • Politics • nytimes.com
Bethune-Cookman scores wild upset victory over Jackson State

The 2026 football season has delivered upsets and stunning losses, but this one might be the most shocking. Over the past two seasons, Bethune-Cookman has gained momentum as a formidable SWAC East contender, but it needed a definitive win over one of the conference’s top teams to prove its worth . Today, that victory came. Bethune-Cookman secured a […] The post Bethune-Cookman scores wild upset victory over Jackson State appeared first on ClutchPoints.

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Oct 24 • 10:14 PM EDT • Sports • sports.yahoo.com
Best AI Tools for Small Business Marketing (2026): CapCut Featured for Creating Professional Video and Visual Content by Expert Consumers

Expert Consumers has recognized CapCut in its 2026 coverage of the best AI tools for small business marketing, highlighting the platform's collection of AI-powered features for creating and editing video, images, audio, and other visual content. The recognition reflects growing interest in tools that support practical marketing activities, including campaign development, promotional content production, and adapting creative assets for different digital channels.

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Oct 25 • 6:30 AM EDT • Business • finance.yahoo.com
Kamala Harris isn’t going away

With her stops in Mississippi and across the country, she’s hearing from many Democratic campaigns who believe having her around helps — and lots of voters who are turning out to show they agree.

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Oct 26 • 5:00 AM EDT • Politics • cnn.com
What's fair game in politics?

Jim Lokay discusses the controversy over Vivek Ramaswamy's attack ad involving his opponent Amy Acton's estranged mother, plus how affordability arguments are shaping the last week of the midterm campaign with Andrew Donaldson of Ordinary Times.

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Oct 25 • 9:08 PM EDT • Politics • fox5dc.com
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race

President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day | Newsradio 1140 WRVA

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Oct 25 • 8:28 AM EDT • Politics • audacy.com
AOC can draw a crowd. The midterms will test whether her politics can win before 2028

WASHINGTON (AP) — Alexandria Ocasio-Cortez has had little trouble drawing a crowd. In a final campaign swing with progressive candidates across the country, the

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Oct 24 • 9:47 AM EDT • Politics • wtop.com
Real Madrid rocked by Thibaut Courtois INJURY BLOW just hours before El Clasico showdown with Barcelona

Real Madrid have suffered a major setback ahead of their crucial Clasico showdown against Barcelona after goalkeeper Thibaut Courtois was ruled out through illness. His late withdrawal forces the club to rely on deputy Andriy Lunin for the vital Liga fixture at Camp Nou.

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Oct 25 • 7:33 AM EDT • Sports • sports.yahoo.com
GIS students mapping trees’ health at Indiana University Northwest

When Joe Blockland’s students at Indiana University Northwest want to call up a tree on campus, they can use an app he created for it.

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Oct 24 • 4:15 PM EDT • Health • chicagotribune.com
Why Joao Pedro Missed Chelsea vs Tottenham

As soon as the lineup dropped for Chelsea's London derby with Tottenham Hotspur, there was one very notable absence. Geovany Quenda was named to the starting eleven with it being clear that Joao Pedro was totally absent from the squad. The Brazilian has been in hot form since the start of the campaign, bagging five …

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Oct 24 • 11:48 AM EDT • Sports • sports.yahoo.com
Netflix’s Leadership Shake Up…Explained

(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) Well, I had a simple article planned for this week. Called “Whoa, I Missed It!”, I’d take a gander at a few important-but-under-the-radar stories I didn’t cover while I wrote about all things “Skydance. (Formerly known as “the saga of Netflix trying to buy Warner Bros., but not Discovery, then Paramount-Skydance bought all of Warner Bros. Discovery”.) Alas, that article will have to wait. Netflix made news. Ironically, my “Whoa, I Missed It!” article would have mostly been about “content” strategy decisions, which is also what today’s article is about. But instead of the entire industry, this article will only cover Netflix’s decision to upend their film and TV content teams. Just that! So that’s the full topic of the day. I’m going to tackle the issue in the opposite direction of the way “stuff” flows: uphill. We’ll start at film, then move onto TV, and then onto the CEOs themselves, and the strategy questions that still remain. But we start with the numbers driving this. Let’s dive in. Subscribe Most Important Story of the Week - Netflix Upends Their Corporate Hierarchy I’ve got a lot of thoughts, but we’ll start with the most common response to yesterday’s article. Let’s Talk Stock Price More than one person, responding to what I published two days ago, pointed out that, well, actually, the thing driving Netflix’s actions is this: In short, stock price! Even if Netflix isn’t obsessed with their own share price—they probably are, but, for the record, my strategic advice to every CEO is to absolutely ignore stock prices, which will, ironically, probably help the stock price long-term—most everyone thinks they are. By the way, I prefer market capitalization to stock prices, because it’s a more apples-to-apples way to compare companies: But there’s an even better way to look at it, and it kinda casts some doubt on the entire push here: price-to-earnings. I have a long list of articles that I wish I had written, and chief among them is an article titled, “Am I Still a Netflix ‘Bear’?” meaning someone who thinks Netflix’s stock is overvalued. As of last summer, Netflix had solved their biggest problem—which for me (circa 2019) was the lack of free cash flow—but their stock was CRAZY overvalued. That’s this chart here: Why did Netflix’s stock price increase to a price-to-earnings ratio of 50 last summer? What financial metric changed so quickly? Nothing. Given that, historically, mature entertainment companies average 10 to 20, with 16 being the average, that increase made little sense. Netflix’s stock swoon these last eight or so months wasn’t irrational; the stock price rise last year was. So if you want a really hot Netflix take, here it is: Netflix’s stock price has been going down because the financial industry recovered its senses, not because of any strategic mistake. Yes, that would imply that cleaning house may have been a mistake. That’s why the charts yesterday are so important, because they show that Netflix did have a strategic problem (a lack of hits) and that’s what they moved to address. (One could also argue the industry drastically overrated Netflix’s growth prospects, but that’s a financial industry problem, not a Netflix strategy problem per se. Some growth estimates are just crazy. *cough* AI *cough*) Now, the last time Netflix’s stock price crashed—circa 2022—it gave them an opening. I’d argue Netflix insiders knew they needed to expand post-COVID-19 crisis, adding advertising, cracking down on password sharing, and dabbling in sports. But if they had done that when their stock price was high, it would give folks a reason to second guess their strategy. (Arguably, last year, when Netflix pursued the Warner Bros. merger, it gave the industry a chance to review their business.) Instead, after the 2022 fall, they had the opening to make strategic changes. We may see Netflix pivot again following this latest slide. For example, the “binge versus weekly” conversation is alive and well again. Same for expanding into theaters even more. And adding both linear channels and streaming bundles. And maybe more either social, user-generated, vertical, or creator content. But the first shift came with who is making the content calls. A Message from Our Sponsor Last winter Pulp Fiction was on Netflix. For those same 90 days, it was also free, with ads, on Pluto TV and the Roku Channel. That is not a glitch, and it is not rare. The title has run on 20 different US streaming services since 2019, across 80 separate windows, and for more than 600 of those days it sat on a paid subscription service and a free ad-supported one at the same time. Almost nobody can see this, because when a title leaves a service, the record that it was ever there tends to leave with it. Reelgood keeps that record, dated to the day rather than the month: 4MM+ movie, show and episode titles across 300+ services globally, with timestamped arrivals, departures and moves across SVOD, AVOD, TVOD and vMVPD. Licensing teams price against every prior window. Rights teams check what a licensee actually delivered, and when. Pick a title you think you know: data.reelgood.com/title-availability Film - Dan Lin Want to know why I don’t opine on individual film or TV executives, especially new hires? Dan Lin. As I always caution, it’s really, really, really tough to predict which executives will succeed in new roles and which won’t. The successful head of co-production/finance partner, Rideback, Lin was considered for the head of DC Studios job before taking the job as the head of Netflix. By all accounts at the time, this was a smart hire. (That’s my read of the news coverage anyways.) But now that Netflix has fired Dan Lin, we got a slew of news stories about how he was doing a terrible job. In sports media, Bryan Curtis, new Substack writer/podcaster from The Ringer, calls this the “now you tell us” story, when you only hear the bad news after a star athlete leaves a sports team. In this case, now they tell us that Dan Lin was bad with talent after he got kicked out the door. So was Dan Lin a flop? It’s actually tough to say. While film moves faster than TV, even two years isn’t really enough time to evaluate a person’s output. The new head hasn’t really taken control. As Emily Horgan noted, it takes much longer than two years to produce animated films, so yeah, it’s definitely too early to judge in that domain. As for live-action films, I just published an article by Brandon Katz called “Netflix’s Summer of Bummer”, but I’d point out Netflix had a bad summer two years ago too. Arguably, their best summer came from KPop Demon Hunters last year and Happy Gilmore 2, the latter of which I saw credited to Lin. Then, the stories came out that Dan Lin clashed with talent, both Ben Affleck and Greta Gerwig, classic “now they tell us” factoids to explain his firing. This may have been true, but also should have been expected given that he was given the mandate to bring budgets back in check, especially after Rebel Moon. So if he made folks upset, well, that’s what he was hired to do! But also, he was described as “well-liked” at his hiring! In that case, I’m a bit sympathetic to Lin, since he may have been undercut by senior leadership, as often happens. Basically, a CEO hires a subordinate to be their “bad cop” and keep budgets in check, but then when talent complains, the CEO ends up undercutting them. That’s how I think you end up with a Narnia movie as expensive as any of the other flops, along with a film executive the town no longer likes. As a result, I think that Netflix is now executing a classic “hire the opposite” move by hiring Peter Rice. This phrase comes from my experience following football and basketball coaching decisions, where teams generally hire the opposite of who they just had. If you have an offense-minded head coach, hire the defensive guy. Or in college football, if you have a strong recruiter, then you pivot to an “X’s and Os” type of guy. Or in pro basketball, if you have a very analytically minded coach, you hire the player-friendly guy. I see that here. After dropping Scott Stuber—arguably a talent-friendly executive with lax budget control—Netflix hired the business guy to keep costs in check. Now Netflix is pivoting back to Peter Rice and presumably a more talent-friendly regime. (Disney, by the way, has done this twice: hiring business guys to succeed talent-friendly Bob Iger. It didn’t work out last time.) When it comes to Peter Rice…we’ll see! Maybe he works out, but maybe he doesn’t. I’d actually say the biggest problem is that Netflix still hasn’t solved its “IP Problem”, in that they don’t own much IP, so they just have a lower hit rate. The new executive won’t solve that. (Though buying Lionsgate would help.) Share “Content” - Bela Bajaria I almost published yesterday’s article after this column, but ended up flipping the order, because it told the story so well. So if you want the data for why Netflix is looking at TV to fix their problems, it’s in that article, this graph in particular: I know I just wrote that it’s often hard to judge executives, but Bajaria ran TV for six years and film for three and a half more. That’s more than enough to judge hit rates, and Netflix needs more hits. That’s the story. Since 2023, Netflix hasn’t had as many hit shows as it used to, and many of its previous power house TV shows have ended their runs (Stranger Things most of all). Also, many shows from 2020 to 2022 probably pre-dated Bajaria’s tenure. (That said, one thing may have been outside of Bajaria’s control, which I explain below.) Let’s lump some content strategy thoughts about Netflix and TV into one place: We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… Why I partially blame Squid Game for Netflix’s latest troubles… What is “the football trap”... Why it might not be the TV shows or films’ fault at all… What change I don’t think Netflix will make... How Bela Bajaria evolved Netflix’s TV strategy in smart ways… Whose departure likely submarined Bajaria’s final few years… One sneaky explanation for Netflix’s content struggles... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support.

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Oct 24 • 3:25 PM EDT • Entertainment • entertainment.substack.com
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How whimsical Hands Gallery became a fixture in downtown SLO for 35 years

The popular shop offers a curated mix of local art, crafts, gifts and more on Higuera Street.

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Oct 25 • 8:00 AM EDT • Business • sanluisobispo.com
AOC can draw a crowd, but the midterms will test whether her politics can win before 2028

WASHINGTON — Alexandria Ocasio-Cortez has had little trouble drawing a crowd. In a final campaign swing with progressive candidates across the country,...

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Oct 24 • 3:45 PM EDT • Politics • post-gazette.com
Here's how Bengals' second half vs Ravens made NFL history

The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.

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Oct 25 • 4:49 PM EDT • Sports • sports.yahoo.com
Serbia's political veteran Vucic outplayed all opponents. Then the students came

BELGRADE, Serbia (AP) — Serbia's populist strongman Aleksandar Vucic dominated the Balkan country's politics for 14 years. Then came the students.

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Oct 26 • 6:13 AM EDT • Politics • wral.com
Campbell County health and food inspections (10/16/26–10/22/26)

GILLETTE, Wyo. — The Consumer Health Services Division of the Wyoming Department of Agriculture conducts inspections of retail food establishments throughout Wyoming (where there is not a local health department that does inspections) to help ensure safety of Wyoming residents. Campbell County establishments are inspected at least once a year by the WDA. All of […]

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Oct 25 • 11:00 AM EDT • Health • county17.com
Business Bulletin: BBB warns of political scams as elections get underway

With some key elections fast underway, many campaigns are reaching out to voters, and people are passionately speaking up for and against hot-button issues. When emotions run high, bad actors look for ways to use people's passion to trick them. Simply said, scammers prey on emotion.

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Oct 24 • 12:00 PM EDT • Business • timesfreepress.com
Alaska Democratic Senate candidate Mary Peltola and her family suffer minor injuries in car crash

Peltola required medical attention after the accident, which happened when another vehicle crashed into the one transporting Peltola and her family, the campaign said.

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Oct 25 • 4:11 PM EDT • Politics • pbs.org
Republican billionaire Rick Jackson is walking a Trump tightrope in his quest to lead Georgia

Jackson’s path differs from Donald Trump’s, and the 72-year-old healthcare magnate and investor brings a vastly different persona to his first campaign. Unlike Trump, who was born to wealth, Jackson spent his early years bouncing through foster homes before launching his first company as a young man.

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Oct 24 • 3:04 PM EDT • Politics • pbs.org
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Cottage Health nurses announce unionization campaign, expect vote on representation by end of the year - Santa Barbara News-Press

Cottage is a healthy workplace and a desirable place to work, administrators say, citing pay increases and hiring and retention trends.

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Oct 24 • 2:51 PM EDT • Health • newspress.com
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Fielded is obsessed with scammers and unhinged Japanese cyberpunk

Some Kind of Animal, the latest record from Fielded, jumps from slinky R&B, to neo-soul, to industrial funk.

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Oct 24 • 11:00 AM EDT • Entertainment • theverge.com
In first midterm rally, Obama blasts Trump administration

Democrats have embraced the former president as their most effective closing messenger in the final weeks of the high-stakes midterm campaign.

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Oct 24 • 5:10 PM EDT • Politics • washingtonpost.com
18 Once-Common Things That Quietly Vanished From Our Lives

"I texted one of those numbers on the TV to buy a ringtone back then. Good times. Then smartphones came around, and I've kept my phone on vibrate for over 13 years now."

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Oct 25 • 6:01 AM EDT • Technology • yahoo.com
Obama rips into Ramaswamy over attack ad: ‘There’s no line he won’t cross’

The Ramaswamy campaign cut in half the length of the ad featuring Amy Acton’s estranged mother after the spot sparked an uproar.

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Oct 24 • 6:03 PM EDT • Politics • washingtonpost.com
She voted for Trump every time. Then came cancer and the bills

Cindy Banda faces mounting medical bills after battling breast cancer.

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Oct 25 • 8:34 AM EDT • Politics • ksat.com
He Took Big Risks to Make Billions. He Wants Georgia Voters to Bet on Him.

Rick Jackson’s run for governor as a political nobody was his latest gamble. The campaign has brought scrutiny to the businesses that made him a fortune.

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Oct 25 • 5:00 AM EDT • Business • nytimes.com
John Sununu is running on his family’s legacy in New Hampshire. His brother is staying on the sidelines

The campaign signs across New Hampshire read “Sununu” in block letters.

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Oct 25 • 12:00 PM EDT • Politics • cnn.com
Business People: Evereve names industry vet Sarah Clary to advise on creative

RETAIL Evereve, an Edina-based women’s fashion retailer, announced it has named Sarah Clary as advisory chief creative officer. Clary previously has led creative direction campaigns and brand strategy for Hill House Home, Veronica…

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Oct 25 • 1:01 PM EDT • Business • twincities.com
Food quality concerns unite Americans far beyond MAHA political support

The Make America Healthy Again (MAHA) movement emerged as part of Donald Trump's 2024 presidential campaign following former presidential candidate Robert F. Kennedy Jr.'s endorsement of Trump.

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Oct 24 • 12:14 PM EDT • Politics • news-medical.net
Ramaswamy built his political career in NH. It's faltering in Ohio.

Many New Englanders remember Ramaswamy from his mad-dash presidential campaign in New Hampshire. Will his political career survive a tumultuous run for Ohio governor?

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Oct 25 • 2:13 PM EDT • Politics • bostonglobe.com
New York Giants' Cam Skattebo Just Saved His Job

New York Giants running back Cam Skattebo saved his job against the Houston Texans.

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Oct 25 • 4:37 PM EDT • Sports • sports.yahoo.com
She voted for Trump every time. Then came cancer and the bills

Cindy Banda faces mounting medical bills after battling breast cancer.

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Oct 25 • 8:34 AM EDT • Politics • wsls.com
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