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New Research Just Linked a Popular Supplement to Faster Progression of Dementia
New research raises some questions.
Insomnia linked to higher risk of dementia, suicide, stroke and other major health issues: Study
Insomnia may be linked to an increased risk of stroke, dementia and several mental health conditions, a new study finds.
Cherokee Nation shines light on Alzheimer’s
To help raise awareness for Alzheimer’s disease and dementia, a proclamation was signed Sept. 15 in the Cherokee Nation recognizing September as World Alzheimer’s Month.
People with diabetes may have another reason to protect their cardiovascular health
Better cardiovascular health, measured using Life’s Essential 8, was associated with a lower risk of mild cognitive impairment among people with diabetes after accounting for genetic susceptibility. Associations with dementia varied by genetic risk, while higher LE8 scores were also linked to greater gray matter volume and lower white matter hyperintensity volume.
Dementia risk more than quadruples among adults with common disorder
Adults with ADHD had more than four times the risk of dementia or mild cognitive impairment, a University of Pittsburgh study of 187,000 people found.
The Big Holes in Wearable Heart Rate Variability And Readiness Scores
On September 9th, Apple announced it was revamping its Apple Watch Health Sensing System, rolling out a Readiness score (0 to 10), and increasing the frequency of heart rate variability (HRV) outputs 24-fold. This can be viewed as upping its competition with various other consumer wearable sensors. These “readiness scores” as a composite of multiple metrics, with heart rate variability (HRV) being front and center for most. The majority of Americans are now using wearable sensors, which equates to well over 100 million adults. HRV and Readiness scores are increasingly being marketed as a measurement of autonomic nervous system health, a digital marker for future disease, a clock for biological age, and a holistic metric to promote healthspan and even longevity. (Apple also introduced a new longevity tab and “Health Age”.) None of this has been proven. In this edition of Ground Truths I am going to review what we know about heart rate variability and readiness scores. Heart Rate Variability HRV is the variation in normal heart cycle timing. The variability of the heart rate, the barely perceptible millisecond changes in time between consecutive heart beats (see R-R intervals in the Figure below, left panel), is due to interplay between the sympathetic and parasympathetic (vagal nerve) inputs. Distinct from heart rate, individuals with the same heart rate can have very different HRVs. It is a rough reflection of the autonomic nervous system (ANS) activity, inadequate to say whether a person’s ANS function is abnormal. For more than three decades, heart rate variability (HRV) has been measured and several studies have found an association of low HRV and clinical outcomes, particularly a link with higher all-cause and cardiovascular mortality. There have also been less well established links of low HRV to risk of early cognitive impairment, dementia, mental illness, Type 2 diabetes and substance abuse. An important reminder is that HRV is a surrogate marker without any established cause-and-effect relationship. If you increase your HRV, that doesn’t mean it will improve health outcomes. In fact, there is no hard evidence for that. All that work linking to health outcomes was done with electrocardiogram (ECG) derived HRV. Now, in the era of consumer wearables, this is getting assessed differently, by optical pulse (yes, the lights you see) plethysmography (PPG) or what is called pulse rate variability (PRV). They are not the same, as shown below (right panel) and only concordant when the delay between the ECG and pulse is kept constant, which basically means at rest. I should mention there’s also what I will call MPV, a mattress mechanical movement sensor, a derived heart rate variability, that companies like Eight Sleep use, even further away from directly measuring HRV. HRV has not one uniform measurement but many different types of quantification, such as RMSSD, the magnitude of difference between successive R-R intervals of normal sinus beats (N-N) or SDNN, the standard deviation of NN intervals, both in milliseconds. SDNN is one of the so-called frequency domain HRVs (others are LF, HF, LF/HF). Different wearable sensors use different metics; Apple has relied on SDNN and nearly all of the others use RMSSD, which is generally considered the more accurate metric. There’s also the different length of time measured, such as for a matter of minutes, all day, or an overnight’s sleep. Short measurements are especially problematic since they don’t capture enough of respiratory modulation and other factors that influence HRV. Share Ground Truths How well does HRV correlate with PRV? There are very limited studies, especially independently done. One that is commonly cited was conducted by Air Force researchers in only 13 healthy adults assessing Oura ring 3 and 4, Whoop 4.0, and Garmin Fenix 6 and showed a correlation coefficient of 0.88 to 0.97 and a mean absolute percentage error from 6 to 10%. The correlation is not a perfect 1.0, but there’s at least a fairly high level of correlation. HRV is supposed to increase during the night due to takeover of the parasympathetic nervous system, and higher during deep sleep. A recent example of my 1 week, all day “HRV,” and one during sleep is shown below. As you can see, the N of 1 data are inconsistent for the same days from different sensors (Oura, AppleWatch, Fitbit Air, and Eight Sleep) by patterns, absolute numbers, and comparison with prior days and weeks. The largest study in over 8 million Fitbit users (the old version, not Google Fitbit Air, introduced in May 2026) gives you a sense of the effect of age, sex, and the 2 different main HRV (here PRV) metrics, with RMSSD on the left and SDRR (=SDNN) on the right below. That study, from data collected in 2018, is a major outlier, since all the more recent ones are tiny with respect to sample size. Many of the companies have not had independent evaluation of their HRV, such as Eight Sleep, but have published a low standard error on their website. There are some other published studies on the correlation between HRV and PRV, but they are all small and only in healthy adults. A scoping review emphasized the lack of study in underrepresented individuals, including the aged, people of color (which affects the PPG signal), and individuals who are underweight or obese. Add the typical adult age 60 plus with one or more chronic diseases. For example, one study in over 900 adults found poor correlation of HRV and PRV, non-uniformly underestimated across many chronic diseases (cardiovascular, endocrine, neurological, respiratory, and others), concluding PRV is “an invalid surrogate for HRV.” A recent systematic review of 43 studies comparing HRV and PRV found reasonable pooled absolute standardized error (HRV as gold standard) but only 10 of the studies provided quantitative synthesis in ideal conditions. Their main conclusion was similarly cautious: “PPG-derived HRV [PRV] should not be regarded as universally interchangeable with ECG-derived HRV across all devices, populations, and recording contexts.” Factors Affecting HRV and PRV That gets me to the long list of factors that affect HRV (and PRV) besides the device, the type of measurement (RMSSD, SDNN or others), the person’s signal, the sensor site, the duration of data capture, if weighting by sleep stage is used, how artifact is processed and corrected. And this list is not complete!: Oura puts out data from their community of users (who input data) on what affects their overnight HRV. The factors currently provided are: no alcohol (increase 8%), melatonin (increase 2%, float tank (increase 2%), wine (decrease 4%), and party (decrease 14%) in overnight HRV. Must be some big parties! Subscribe What is a PRV measurement good for? It has been falsely characterized as an index of “autonomic balance” and a specific indicator of stress. A 2018 review of the studies available for HRV and its relationship to stress, not using any of the current wearables, found that stress can lower HRV. But so can many other factors. The non-specificity of the signal, indexed to the table above, is striking. Evidence from a UK Biobank study of over 46,000 participants with actual HRV looked at genetically predicted HRV, a genetic risk score, that failed to show the expected HRV-mortality link, indicating that _HRV is likely not causa_l, but rather a reflection of person’s physiologic state. A review of consumer wearable HRV data from 5 longitudinal studies showed that nighttime PRV was not associated with perceived stress, and surprisingly higher HRV, in the largest cohort (N=717 participants), was correlated with higher stress. An Oura ring cohort of 525 first-year college students found a link between overnight PRV and perceived stress, but that was also seen with resting heart rate, sleep, and respiratory rate. Several very small studies have examined the relationship of HRV and athletic injuries or guiding training with mixed, and predominantly negative results. HRV biofeedback training with paced breathing had no significant effect on reducing stress or raising HRV, as demonstrated with sham controlled trials. When HRV for multiple days showed a decline in conjunction with body temperature, the Oura ring published data for prediction of Covid. The WHOOP company sponsored an observational study, published in 2026, of 30,000 users for 72 weeks, without a control group, that reported reduced alcohol intake (5.8 % points) by self-report. That doesn’t tell us much, and particularly about the merits of HRV for behavioral change. If you use the same device and conditions as longitudinal trends for multiple (at least 2-3) weeks that may be the one way to get something useful from the measurements. Data for overnight sleep with minimal motion and using RMSSD is the best proxy for real HRV. The reason to look at trends rather than any given night is that it more likely represents something, even though you won’t know with certainty what the “it” is. Keep in mind there are no data, no peer-reviewed evidence, to show that HRV fluctuation in-person has any correlation with health outcomes. Share Readiness Scores These are proprietary scores that integrate different metrics for each of the wearables: no algorithms have been disclosed. They are unvalidated against health outcomes. In a review of 14 composite health scores of readiness and recovery, HRV contributed 86% to the scores, followed by reading heart rate (79%), physical activity and sleep duration (both at 71%). That review noted the substantial variability in measurement protools and lack of standardization. Sleep staging is notoriously inconsistent and inaccurate by these sensors, which adds further to the HRV uncertainties for what the scores, which use sleep stage data, mean. Only resting heart rate has been shown consistently across devices to be extremely accurate. I’ve made a Table to summarize what we know about which metrics are included, the scores, any peer-reviewed studies that compared the readiness score with health outcomes, and the corresponding (if any, NA-not available) citation. You will note that some companies do not use the term “readiness," such as WHOOP for recovery, and Garmin, which has 2 different scores, one of which is Body Battery. Eight Sleep uses the term “Fitness Score.” They all include HRV; Apple includes a new metric they call “Recovery HRV” which among other components uses 7-days of sleep, but it is unclear what this means or how it is differentiated from other scores (there are clearly no data for outcomes). We have no knowledge of how the different components are weighted or whether any of these scores are better than resting heart rate, HRV alone, physical activity, or any other single metric. Since none of these are standardized, they are not interchangeable, so if you get a 90 for Oura that has no relationship to a 90 on a Google Fitbit Air. Notably, the company can update its algorithm for readiness score at any point without notification to device users. Without any useful evidence of actionability for these scores or established relationship with health outcomes, it is hard to make a case for their value. At the Apple recent announcement they showed their Readiness score (0-10) on the watch (Figure below) but there are no published data on this score, not even on their website. It’s available only on their new Watch Series 12 or Ultra 4 [of course, ;-)]. That exemplifies the problems with these scores, lack of data and evidence for being meaningful to promote health. Perhaps the best study (which isn’t saying much) is the WHOOP Recovery for golfer performance, because it did correlate with an objective outcome, even though there was no control group and the authors were all from the company. Among the 389 pro golfers, an absolute 10-per cent point increase in Recovery score was associated with about 0.5 fewer strokes per round. But that’s hardly a health outcome! WHOOP is also conducting a study in over 2,700 runners to see if their recovery score will be linked to less injuries and improved performance, but that is not yet published and has no control group or randomization. Putting This in Context For two decades I’ve been enthusiastic about the potential for digital health and particularly wearable biosensors. Over the years, we’ve seen some great progress for their ability to promote physical activity and accurately detect atrial fibrillation (the first FDA cleared deep learning AI for consumers). That work was the subject of rigorous research. But there are holes in the data and evidence for other metrics. One notable one is the “VO2 max” story that I wrote about earlier this year. At that time many subscribers asked me to cover heart rate variability, which I finally got to here. When I dived into the research and publication for HRV and readiness scores, I expected to find at least some that were of high quality and demonstrated their utility by linkage to health outcomes. To my surprise, I found none. The wearable sensor measurements for HRV (PRV) are, for the most part, accurate, but that validation work has only been done in small studies of healthy adults and does not take into account the long list of factors, from the device, software side, and the user side, that affect HRV measurements. Moreover, this metric chiefly relies on optical sensing and, as we have learned for heart rate PPG sensing, may be less accurate in people of color. Keep in mind that all of the health outcome association evidence comes from ECG-derived HRV; none are from wearable sensor data. I will repeat the key point: there's no peer-reviewed evidence to show that in-person HRV fluctuation—or efforts to raise your HRV— has any correlation with health outcomes. For those of you who look at your HRV on awakening, or even 2+ week trends of it being low, I hope this context helps to relieve any anxiety. Yes, low HRV (not PRV) has been shown to increase risk of some diseases as summarized above. But efforts to raise your HRV—a surrogate metric— has not been established for improving any health outcomes. HRV does not have any evidence of causality (the genetic evidence actually goes against this possibility). In this summary, I have not included data for other wearable sensors such as Polar, Samsung, Withings, Suunto, Amazfit, Coros, Ultrahuman, or additional mattress sensors. These are beyond my first-hand experience, and as far as I know from my in-depth review none have any peer-reviewed published data that differ from the 6 sensors I’ve reviewed here. From the points I’ve gone over above, we’re not ready for readiness scores. Besides being proprietary, they are predominantly based on metrics that have their own issues. It’s compounding the problem, like building a house without a solid foundation that has never undergone a rigorous inspection, and then selling it. Like I mentioned for PRV, you can look at trends over weeks rather than any single day, to get a handle, but even that may not be helpful. There’s simply no evidence that these scores meaningfully relate to health outcomes. I’d emphasize they might, but that requires doing prospective or randomized studies to prove it. None exist. There’s great promise for HRV/PRV utility_. For example**,**_ Prof Maiken Nedergaard, who discovered the brain glymphatics that are essential in eliminating metabolic waste products from the brain during sleep, has posited that HRV could be a non-invasive marker for neuromodulator oscillations, brain-body regulatory circuits, and brain clearance. That would be extremely useful, but like everything else on HRV and readiness scores it requires solid research and validation. The lay media isn’t helping much to get the story straight. Earlier this year The Economist published a piece entitled “The most useful indicator of your overall health” which ordained HRV as an “accumulated stress score.” That’s akin to the false assertion about VO2max: “V02 max is the singular most powerful marker for longevity.” As I’ve summarized here, that is not established. The fact is that so many things can lower HRV, including physical exercise (especially an intense workout), reduced sleep quality, stress, the list above, no less the device, signal, and software. Whatever fluctuations observed have not been correlated with any health outcome. Sadly, “datamaxxers” are widely using HRV and readiness scores that have never been validated to mean anything. We already know that for some people using the sensors for sleep metrics, it can induce “orthosomnia,” an obsession to get high sleep quality, with associated high levels of anxiety. In an experiment done by a company to promote sleep quality for its employees, “For those employees who did use the trackers, many reported feeling perfectly rested until their tracker told them they had had a terrible night. Others were told that they had slept like a baby when they had actually been lying awake worrying about the quality of their sleep. “ The same problem can result from preoccupation with HRV or readiness scores, with anxiety that would lead to further reduction in both. It you are using a wearable like >100 million American adults, it’s OK to look at these data, but contextualized with the major caveats reviewed here. If you are one to require evidence that HRV or readiness scores are linked to health outcomes, you may not even want to look. The companies make it hard to turn them off! Let me end with the companies that make and sell wearables. Apple’s doubling down on HRV (24-fold more reporting and heart rate very 5 seconds) and introduction of a Readiness score tells us that consumers have bought into these metrics and they are joining the club. However, all of this is occurring with a backdrop of tens millions of users, claims about the data that are not backed up by adequate evidence, marketing way out in front of whatever limited data exists, and not being transparent about their readiness score algorithms. The companies can well afford to do the research that is needed to connect these metrics with health outcomes show, once and for all, that increasing HRV or using readiness scores promotes our health. If they believed and invested in the products they are selling, we’d not be in this position of not knowing. That’s essentially where we are with HRV and readiness scores. Perhaps someday this will change and we’ll have good reason to embrace them. NB: I wrote this post. No AI. I have no conflicts of interest with any of its content. Loading... Ground Truths has 215,000 subscribers from every US state and 214 countries. There are over 300,000 followers of Ground Truths so more than 90,000 folks who can easily convert to be free subscribers. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. If you’re not a subscriber, please join! If you found this interesting PLEASE share it! Share Ground Truths The proceeds from all voluntary paid subscriptions go to support our summer internship program. It enabled us to accept and support a record number of 62 summer interns that joined us in 2026! These are high school, college and medical students selected from thousands of applicants. We couldn’t do this expanded program without the funds coming in through Ground Truths. Thank you!
One type of sleep linked to dramatically lower risk of dementia, Parkinson's and 81 other diseases
Greater REM sleep was linked to 80% lower Parkinson's risk and 46% lower dementia risk in a major study of over 95,000 adults tracked for years.
Dementia is taking a toll on Sept. 11 responders. A federal health program doesn’t cover it.
Doctors and scientists are pushing to get dementia added to a list of medical conditions connected to Sept. 11.
Neuropsychologist finds gaps between treatment and science of ALS, dementia in her own family
For A. Campbell Sullivan, PsyD, this time it's personal. As a neuropsychologist and clinical associate professor of neurology at the Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases ...
San Antonio study sheds new light on dementia in Hispanics
UT Health San Antonio researchers found that a rare type of dementia that affects younger people is more common among Hispanics than was previously realized.
From Boosting Mental Health to Reducing Dementia Risk, Here's Why Reading Is Extremely Good for You, According to Science
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This seasonal habit promotes healthy aging and may reduce dementia risk in older people
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This lifestyle program improved cognition 55% more than basic health advice
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Bruce Willis makes rare public appearance at daughter’s wedding amid dementia battle
Tallulah Willis, the daughter of the “Die Hard” star and ex Demi Moore, married Justin Acee last week.
Eastlake science students make district history
Three Eastlake High School students made Sweetwater Union High School District history this year when they became the first students from the district to qualify for the International Science and Engineering Fair, an international competition that brings together some of the top high school researchers from around the world. Ronald Wyatt, Giles Del Priore and Ihan Sung advanced to the competition after successful runs at regional and state science fairs. Sung went a step further, placing fourth in the chemistry category at ISEF. The students were recognized on Aug. 10 during a Sweetwater Union High School District board meeting at the district office in Chula Vista.For Wyatt and Del Priore, recent Eastlake graduates, the journey began with a shared concern about dementia and the challenges faced by families caring for loved ones with memory impairment. Their engineering project, “Design and Evaluation of a Behaviorally Grounded Caregiver-Governed AI Companion for Individuals with Memory Impairment,” earned the Sweepstakes Award at the Sweetwater District STEM Fair and first place in its division at the Greater San Diego Science and Engineering Fair. The project explored whether Artificial Intelligence could provide companionship and support while helping reduce stress for people with dementia and their caregivers. “Our inspiration came from personal experience. Both of us have seen family members and loved ones affected by dementia, and we’ve witnessed how overwhelming the caregiving process can be,” Wyatt said. Del Priore said the students also wanted to address the high cost of third-party health care services while creating something that could potentially help their own families as well as people elsewhere. The students developed an AI system designed with safeguards intended to prevent misinformation reinforcement, emotional escalation and unsafe responses. In 240 controlled trials involving memory, identity, agitation and neutral scenarios, they said the system consistently prevented harmful incorrect reinforcement while using context-aware silence, de-escalation and caregiver verification. The project required the students to combine Artificial Intelligence, psychology, neuroscience and human-computer interaction. For Del Priore, one of the biggest technical challenges was getting the AI companion to communicate verbally with a patient. Hardware limitations required the students to collaborate with multiple Python libraries for speech-to-text and text-to-speech functions while keeping the cost of the companion low. “For us, the biggest challenge was translating complex behavioral and cognitive care principles into a functioning AI system,” Wyatt said.Qualifying for ISEF was a milestone that student expected. The international competition proved to be another milestone. “Competing at ISEF was an incredible experience and unlike anything we’ve ever done before,” Del Priore said. “Being surrounded by some of the most talented young researchers from around the world was both inspiring and motivating.” He said the experience stood out because of the emphasis on collaboration, innovation and scientific discovery. “The most memorable part was seeing how people from completely different backgrounds and disciplines approached solving real-world problems with creativity and passion,” he said. The students also credited teachers and mentors who supported their work. Del Priore said his sophomore-year AP Physics teacher, Dr. Price, was particularly influential. “Through all of my personal and academic struggles, Dr. Price always believed in me,” Del Priore said. “All of his faith in me really molded me into the person I am today and helped create my love for science even through tough times.” Wyatt is continuing his education at UC Santa Cruz, where he plans to study biomolecular engineering and bioinformatics, with an interest in research involving Artificial Intelligence, biology and health care. Del Priore plans to double major in chemistry and accounting. Sung, a rising Eastlake senior, qualified for ISEF after winning first place in the Engineering: Energy, Materials & Transport category at the Greater San Diego Science and Engineering Fair and first place in chemistry at the California Science and Engineering Fair. His project, “Renewable Ammonia Electrochemical Synthesis by Glow Discharge with an Iron-Based Catalyst,” involved a device he designed and engineered to produce renewable ammonia, with potential applications in fertilizer production and energy storage. Sung became interested in the project after considering the relationship between food insecurity and fertilizer costs. His system uses plasma to break apart nitrogen molecules so they can interact with hydrogen and form ammonia. At ISEF, Sung competed against more than 1,700 students from 65 countries and earned fourth place in chemistry. “I am proud to become one of te first students in the district to qualify for ISEF because this milestone can inspire others in the district to attain similar goals,” Sung said.
Alzheimer’s may leave a mark on the brain long before plaques appear
Brain changes associated with Alzheimer’s may begin at least seven years before amyloid plaques become detectable with current PET scans. Researchers uncovered the signal by tracking healthy older adults with repeated brain imaging over nearly 20 years. The discovery could help scientists identify Alzheimer’s earlier and suggests that important disease processes may start before visible plaque buildup.
September 17, 2026: IMPACT Collaboratory Seeks Applicants for 2027 Health Care Systems Scholars Program
The NIA IMPACT Collaboratory, a program to advance pragmatic clinical trials of interventions for people living with dementia and their care partners, has announced a request for applications for its […]
Switching on brain cells: The Nobel-winning science of optogenetics
In optogenetics, scientists control neurons by stimulating them with light—potentially unlocking breakthroughs for conditions such as dementia, depression and blindness.
Reading for pleasure: Lifelong health and cognitive benefits
Reading for pleasure—from tucking into a Jane Austen classic to devouring a Heartstopper graphic novel—is linked to better mental health, greater empathy and a lower risk of dementia, say researchers.
New dementia prevention guidance expands risks
Brain health is influenced by more than genetics and aging alone. Learn WHO's latest dementia prevention guidelines and modifiable risks.
Why scientists are stoked about mysterious black hole stars
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What are statins? And can healthy people use them to prevent heart disease and dementia?
New evidence shows more people might benefit from this cholesterol-lowering medication than we previously thought. But that doesn’t mean everyone should take one.
UT Health San Antonio neuropsychologist finds gaps between treatment and science of ALS, dementia in her own family
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Brightcore Nutrition: How gut health impacts your cognitive function
Chances are Alzheimer’s or Dementia has touched your life in one way or another. The statistics behind the disease are staggering. According to the World Health Organization, 57 million peopl…
Vandalia Health Davis Medical Center to offer free workshop for dementia caregivers
Vandalia Health Davis Medical Center will offer a free dementia-caregiver workshop November 4 in Elkins. Registration is required by October 19, and space is limited.
Dog cognitive decline treatment: USF Health develops new gene therapy
Researchers at the University of South Florida are developing a gene therapy injection aimed at treating canine cognitive decline. The team hopes the one-time treatment will target the disease directly and give pets more quality time with their families.
Why Fermented Foods Are Important for Maintaining a Healthy Gut
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Manchester brain health clinic aims to 'transform' dementia care
The Alzheimer's Society says the clinic in Manchester is the first of its kind in the United Kingdom.
The dementia vaccine some of us are taking without realising
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Major brain changes that occur around age 50 could impact dementia risk
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A little-known protein may be fueling Alzheimer’s — and scientists found a way to block it
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Growing Research Reveals Potential Link Between Eye Health & Dementia Risk
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Health board admits failings that led to dementia patient's death
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Take Charge of Your Health Today: Safe and affordable housing
JENNIFER THOMPKINS Alzheimer’s disease and other forms of dementia can affect any family, but access to diagnosis, treatment and support is not equal across communities. For many African Americans, the path to care is complicated by limited access to health services, transportation, healthy food, reliable information, and trusted organizations. Those barriers, according to Jennifer Thompkins, president of […]
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Why You Move Matters When It Comes To Brain Health, Dementia Risk
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holding space in music therapy for patients with dementia
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Brain Health WA resource aims to reduce dementia risk
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German and US scientists win Nobel Prize in medicine for research on brain activity
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New Israeli fund seeks $40 million to invest in mental health and longevity
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Scientists create mice with part-human brains
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Dwayne Johnson Says Role as Stuntman With Dementia Has Been ‘Life-Changing'
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7 new dementia risk factors revealed — including one millions struggle with
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Researchers warn social media driving harmful misuse of Alzheimer’s blood tests
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This Common Health Problem Is Linked to a 58 Percent Higher Risk of Cognitive Decline, New Study Finds
A study of more than 833,000 adults found that one trait was associated with a higher risk of dementia.
Scientists find a new layer of Alzheimer’s hidden in the genome
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Some dementia patients grow lucid near the end. Scientists hope it’s a clue.
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Music legend’s husband denies she has dementia after performance cutbacks, troubling reports
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Want to lower your risk of dementia? It doesn't involve a blood test
New blood tests are helping doctors diagnose whether Alzheimer’s or something else is causing a patient’s memory problems
This lifestyle program improved cognition 55% more than basic health advice
Older adults at risk of dementia improved their memory and thinking after following lifestyle programs combining exercise, healthy eating, cognitive training, and social engagement. Those who received regular coaching and structured support improved substantially more than participants given general health advice.
Empath Health Unveils Dementia Education Program for Clinicians, Caregivers, First Responders
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For Your Health
Dementia touches many lives — in many different ways. And most of us likely have some firsthand experience with it, whether it’s with an aging family member or friend or neighbor. …
Manhattan home health aide stabbed by client with dementia after serving her pancakes
Barbara Salberg, 66, was hit with a slew of charges including attempted murder following the stabbing in her luxury Upper East Side apartment.
Can HRT help prevent dementia? New research suggests it might
As debate continues over whether hormone replacement therapy can protect against dementia, new studies suggest timing and formulation are key.
Glucosamine, a popular joint supplement, linked to faster Alzheimer’s progression
A large health-record analysis found that glucosamine use was associated with a 25% higher likelihood of mild cognitive impairment progressing to dementia. Lab experiments suggest the popular joint supplement may intensify an abnormal sugar-tagging process in the Alzheimer’s brain, although researchers say clinical trials are needed to determine whether it actually causes harm.
Why dementia is preventable – and the new tools that can reduce your risk
On World Alzheimer’s Day, a look at advances in dementia diagnosis and treatment, and why much of the risk may be within our own control.
Dementia Expected To Double Worldwide By 2050
By Dennis Thompson HealthDay ReporterWEDNESDAY, Oct. 14, 2026 (HealthDay News) — Dementia cases are set to double within the next 25 years worldwide, warns a new study. There are expected to be 24.7 million new cases of dementia by 2050, up from 11.4 million in 2023, researchers reported Oct. 12 in ...
Ultra-Processed Foods and the Aging Brain: What Does the Science Say?
Eating more ultra-processed foods has been linked to increased risk for dementia and Alzheimer's disease, as well as other non-brain health effects, including diabetes and cancer. But why do these foods affect our brain health?
Millions Of Us Could Develop Dementia In The Coming Years – 3 Experts Weigh In On Where The Science Is Heading
Where will dementia research be in 10 years’ time?
Heavy caffeine users and deeper sleep; wonders of microscopic life; preparing for life after an Alzheimer’s diagnosis; plus other stories with Vanderbilt Health sources
Beth Malow, MD, Professor of Neurology and Pediatrics in the Vanderbilt Sleep Division, was quoted in Women’s Health about a surprising study from the Journal of Psychopharmacology indicating that heavy caffeine users get deeper non-rapid-eye-movement sleep, even while sleeping less time. The New York Times quoted Dylan Burnette, PhD, Associate Professor of Cell and Developmental Biology, in a story (with videos) about the wonders of the microscopic life all around us. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Prevention (rabies vaccinations); Healthline (update on the Cyclospora outbreak); Prevention again (hundreds now sickened in measles outbreak); and AARP (“How do we know vaccines are safe?” video interview and transcript). Science posted a story about a new NIH research center on vaccine harms. The piece quotes Kathryn Edwards, MD, Professor of Pediatrics, Emerita. Lealani Mae Acosta, MD, MPH, Associate Professor of Neurology, was quoted in an Everyday Health story about how a person, after a diagnosis of Alzheimer’s disease, can enrich their life and prepare for the future. Amalia Peterson, MD, Assistant Professor of Neurology, was quoted by Everyday Health in a piece about common medications linked to lower dementia risk.
This Is the No. 1 Risk Factor for Dementia That You Can Actually Prevent, According to a Geriatrician
In TODAY.com’s Expert Tip of the Day, a geriatrician reveals the top modifiable risk factor for dementia during mid-life, and how to address it.
PTSD, Health-Related Social Needs Together Increase Cognitive Risks Significantly in Veterans
A recent study asked a question critically important to VHA clinicians: Are post-traumatic stress disorder (PTSD) and health-related social needs (HRSNs) associated with incident mild cognitive impairment, Alzheimer’s disease and Alzheimer’s disease-related dementias among U.S. veterans?
UT Health San Antonio neuropsychologist finds gaps between treatment and science of ALS, dementia in her own family
Her journal article urges more support for those facing inherited neurodegenerative diseases Contact for media: Steven Lee, (210) 450-3823, lees22@uthscsa.edu SAN ANTONIO, Sept. 2, 2026 – For A. Campbell Sullivan, PsyD, this time it’s personal. As a neuropsychologist and clinical associate professor of neurology at the Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases at UT Health […]
This Seasonal Habit Promotes Healthy Aging and May Reduce Dementia Risk in Older People
In TODAY.com’s Expert Tip of the Day, a doctor reveals how one routine vaccine can protect the body and brain as we age.
UT Health San Antonio neuropsychologist finds gaps between treatment and science of ALS, dementia in her own family
As a neuropsychologist and clinical associate professor of neurology at the Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases at UT Health San Antonio, A. Campbell Sullivan, PsyD, is on the front lines daily of groundbreaking research and patient care in frontotemporal dementia and other neurodegenerative disorders.
Will We Ever Understand Dementia?
Since the days of Dr. Alzheimer himself, there has been a dream that severe senility might have an explanation — and a cure. The search for both has never been more urgent.
Glucosamine, a popular joint supplement, linked to faster Alzheimer’s progression
A large health-record analysis found that glucosamine use was associated with a 25% higher likelihood of mild cognitive impairment progressing to dementia. Lab experiments suggest the popular joint supplement may intensify an abnormal sugar-tagging process in the Alzheimer’s brain, although researchers say clinical trials are needed to determine whether it actually causes harm.
How Alzheimer’s and dementia patients teach Wisconsin’s next generation of health care workers
Through the New Friends program, students get experience connecting with people living with cognitive changes, and mentors get social connection during a particularly lonely time.
From Boosting Mental Health to Reducing Dementia Risk, Here's Why Reading Is Extremely Good for You, According to Science
Mounting evidence suggests that regularly cozying up with a book can increase brain and mental health, improve literacy and math skills, and even slow cognitive decline. What's more, fiction seems to have the added benefit of introducing readers to others' perspectives
Friends of BrainHealth grants advance dementia prevention and brain health research
For nearly 20 years, the Friends of BrainHealth donor circle has helped turn promising ideas into innovative brain health research.
Exploring the science of keeping your mind sharp as you age
Everyone wants to keep a sharp mind as they age, especially as dementia cases continue to rise. Now, a growing body of evidence suggests almost half of the key risks for cognitive decline can be prevented or delayed. Horizons moderator William Brangham explores the emerging science that can help protect against dementia with Dr. Jonathan Rosand of the Global Brain Care Coalition.
Scientists Reveal The Optimal Amount of Sleep For Lower Dementia Risk
A huge analysis uncovered the sweet spot.
Your gut may be making a molecule that raises Alzheimer’s risk
Scientists have linked a gut bacterial compound called ImP to greater Alzheimer’s risk, harmful brain protein buildup, and faster cognitive decline. The finding raises the possibility that reducing ImP in the blood could one day help slow or prevent dementia.
Common vaccine linked to 24% lower dementia risk in older adults
A Brown University study found Shingrix reduced dementia risk by 24% over four years, building on prior research linking the shingles vaccine to brain health.
More REM sleep linked to lower risk of 83 diseases
A large study tracking more than 95,000 people suggests that how you sleep may be linked to your risk of developing dozens of diseases. People who spent more time in REM sleep had lower risks of 83 conditions, including dementia, heart failure, and Parkinson’s disease, while more deep sleep was associated with lower risks of conditions such as type 2 diabetes and major depression.
James L. West Center Executive Speaks at National Conference
Jaime Cobb-Tinsley, Vice President of Family & Professional Education at the James L. West Center for Dementia Care, participated in a best-practices panel
GRN gene: When genetic information upends life
A family in Argentina has become an ideal case to study frontotemporal dementia. Across generations they transmit a mutation in the GRN gene, responsible for producing a protein essential to healthy brain cell function
Scientists create human-mouse hybrid
Animals will be used to study causes of neurodevelopmental disorders such as dementia, profound autism and cerebral palsy
HOMETOWN HEALTH: Epilepsy leading to greater risk of developing dementia before 65, study shows
Researchers said the overall risk of dementia is still low, and more study is needed to understand the link.
I love my mom with dementia. I don't love being her caregiver.
Angela Davis, a 65-year-old in New Orleans, has cared for her mother with dementia, facing high costs, and balancing work and personal life.
What Science Says About Tooth Loss and Your Brain
Studies link tooth loss to higher risk of cognitive decline and dementia. Here's what the research shows, the leading theories, and what you can do now.
Drugs are widely used to sedate dementia patients. Her sons wanted to keep her off them
Potent sedating medications are often used on agitated people with dementia in long-term care facilities despite federal efforts to discourage them. A clash over whether to drug a Michigan woman illuminates the wrenching decisions families and guardians face.
HHS Unveils Bold New Plan to Combat Alzheimer’s and Dementia
HHS announced the 2026 Update to the National Plan to Address Alzheimer’s Disease and Related Dementias.
A 26-Year Study Linked 3 Midlife Health Risks to Nearly 13 Fewer Dementia-Free Years
Recent research identified an associational relationship between the three factors and cognitive decline.
Bruce Willis’ wife says he’s still ‘very present’ in health update amid dementia battle: ‘Learned to adapt’ (exclusive)
EW has an exclusive look inside Emma Heming Willis’ life with Willis, who still has “beautiful moments of joy and connection” amid “terrible” diagnosis.
Health records link ADHD to more than fourfold higher risk of later cognitive impairment
A new study led by University of Pittsburgh School of Medicine researchers finds that adults with attention-deficit/hyperactivity disorder (ADHD) face a significantly higher risk of developing dementia ...
New report examines links between climate, pollution and brain health
A report by the Neuro Climate Working Group reveals that extreme heat and air pollution significantly increase the risks of dementia and mental health issues.
RFK Jr., Dr. Oz visit Broward Health to outline new federal Alzheimer's initiative
The FDA program's first initiative, the Alzheimer's Prevention Accelerator, focuses on finding medical products that can help delay or altogether prevent Alzheimer's disease and related dementias.
Bruce Willis still ‘very present’ amid ‘terrible’ dementia diagnosis (exclusive)
Bruce Willis’ wife, Emma Heming Willis, has given a health update on the actor and how his family ‘learned to adapt’ amid his ‘terrible’ dementia diagnosis: ‘He’s very present.’
First person-centered measure of dementia caregiving styles improves partner, patient outcomes
First person-centered measure of dementia caregiving styles improves partner and patient outcomes.
Reading for pleasure linked to better mental health and greater empathy
Reading for pleasure – from tucking into a Jane Austen classic to devouring a Heartstopper graphic novel – is linked to better mental health, greater empathy and a lower risk of dementia, say researchers.
Bruce Willis makes rare appearance at daughter's wedding
Bruce Willis showed up for his daughter Tallulah Willis's wedding as he navigates the progression of frontotemporal dementia.
Shingles vaccine linked to 24% lower dementia risk
Older adults who received the Shingrix shingles vaccine were 24% less likely to be diagnosed with dementia over four years in a study of more than 500,000 people. Researchers estimate the difference could amount to roughly one dementia case prevented for every 17 people vaccinated.
Dementia risk may be linked to seemingly harmless daily habit, new research suggests
Even naps under 30 minutes raised dementia risk 40% in a Johns Hopkins Bloomberg School of Public Health study of nearly 1,000 older adults.
Want to lower your risk of dementia? It doesn't involve a blood test
New blood tests are helping doctors diagnose whether Alzheimer’s or something else is causing a patient’s memory problems
Lower blood pressure may boost brain health, UT Health study finds
Researchers found that even a small drop in blood pressure can slow a brain disease that is a major cause of strokes, cognitive decline and dementia.
CMU Cognitive Psychologist’s Work Has Generated Over 14,000 Language Studies
TalkBank, a family of 14 databases has become the basis for language science research on everything from how children learn to speak and how people pick up a second language to patterns that can reveal the onset of dementia.
Lower blood pressure may boost brain health, UT Health finds
Researchers found that even a small drop in blood pressure can slow a brain disease that is a major cause of strokes, cognitive decline and dementia.
Bruce Willis makes rare appearance at daughter Tallulah's wedding
Bruce Willis showed up for his daughter Tallulah Willis's wedding as he navigates the progression of frontotemporal dementia.