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Ana Tsereteli: Four Days of Science, Friendship and Unforgettable Moments at ESMO 2026
Ana Tsereteli: Four Days of Science, Friendship and Unforgettable Moments at ESMO 2026 / Ana Tsereteli, cancer, ESMO, esmo 2026, ESMO Congress, ESMO Congress
Bruna David: A Busy ESMO 2026 Filled with Science, Friends and Meaningful Connections
Bruna David: A Busy ESMO 2026 Filled with Science, Friends and Meaningful Connections / Barcelona 2027, Bruna David, cancer, Cancer research, ESMO, esmo 2026,
Rille Pihlak: New Science, New Friendships and New Hope for Cancer Patients
Rille Pihlak: New Science, New Friendships and New Hope for Cancer Patients / cancer, ESMO, esmo 2026, ESMO Congress, ESMO26, European Society for Medical
Mahoning Valley arts and entertainment
Art ASHTABULA ARTS CENTER, 2928 W. 13th St., Ashtabula: 2026 Paul and Norma Tikkanen Painting Prize exhibition, through Saturday. Hours are 9 a.m. to 5 p.m. Monday through Thursday, 9 a.m. to 4 p.m. Friday and 9 a.m. to 1 p.m. Saturday. ashtabulaartscenter.org and 440-964-3396. BUTLER INSTITUTE OF AMERICAN ART, 524 Wick Ave., Youngstown: “In […]
Ioanna Nixon: Improving Cancer Care Through Science, Innovation and Partnership at ESMO 2026
Ioanna Nixon: Improving Cancer Care Through Science, Innovation and Partnership at ESMO 2026 / cancer, cancer care, ESMO, esmo 2026, European Society for
Matteo Lambertini: Celebrating Science, Collaboration, and Progress in Oncology at ESMO 2026
Matteo Lambertini: Celebrating Science, Collaboration, and Progress in Oncology at ESMO 2026 / cancer, ESMO2026, ESMO26, Matteo Lambertini, OncoDaily, Oncology
Machine learning models predict common cancer risks using routine health data
Machine learning models using routinely collected health information, such as blood tests, medical history and lifestyle factors, could help identify people at higher risk of several common cancers, according to an international study reported at the ESMO Congress 2026.
Breakfast News: Science Strikes Back at Cancer
Cancer trial data shines at ESMO 2026, earnings flood after tough market week, and more…
Emad Shash: Beyond Science, It’s the People Who Make ESMO Special
Emad Shash: Beyond Science, It’s the People Who Make ESMO Special / Amalya Sargsyan, Arpi Asminian, cancer, Emad Shash, ESMO, esmo 2026, ESMO 26, Mona
Martin Ignacio Zapata Laguado: Negative Trial in Newly Diagnosed Glioblastoma at ESMO26
Martin Ignacio Zapata Laguado: Negative Trial in Newly Diagnosed Glioblastoma at ESMO26 / cancer, cancer care, cancer treatment, ESMO26, glioblastoma, Martin
Des Moines bishop says White House 'exploited' visit for politics
Bishop William Joensen was one of several invited to the White House for a private meeting they say is being used for "partisan political purposes."
#ESMO26: Merck and Moderna's cancer vaccine data were 'a triumph of science.' And now, the work begins
Merck and Moderna’s intismeran cut melanoma recurrence risk 42% at ESMO; experts weigh other tumors, manufacturing and boosters.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Bold Science, Big Questions, a Defining Moment for Cancer Immunotherapy - Agenus
Bold Science, Big Questions, a Defining Moment for Cancer Immunotherapy - Agenus / Agenus, BOTBAL, Cancer research, esmo 2026, Garo Armen, Jennifer S. Buell,
Guardant Health to Highlight Advances in Liquid Biopsy for Cancer Monitoring at ESMO 2026
Guardant Health and partners will present 25 abstracts on liquid biopsy advances for cancer monitoring at ESMO 2026.
Is this America's most normal congressional race? San Diego candidates run on classic platforms
Democrat Marni von Wilpert and Republican Jim Desmond are vying for the 48th Congressional District’s swing voters with moderate, establishment politics
Julien Boone Heads to ESMO 2026 to Explore Emerging Science in Oncology
Julien Boone Heads to ESMO 2026 to Explore Emerging Science in Oncology / cancer, cancer medicines, esmo 2026, European Society for Medical Oncology, Fanny
ESMO 2026 Survival Guide for Advocates: Science, Spanish, Stickers and a Little Madrid Magic
ESMO 2026 Survival Guide for Advocates: Science, Spanish, Stickers and a Little Madrid Magic / cancer, ESMO, ESMO2026, Lived Experience, Lived Experience
Desmond Bane Emphasizes 'Togetherness and Accountability' With Orlando Magic
After a disappointing postseason exit, the veteran guard signals a shift in culture, focusing on quiet work and internal standards to propel a revamped roster forward.
Iowa's 3 top congressional races move in Democrats' favor
Cook Political Report analysts see a tougher path for Iowa Republicans in November, moving two House races to leans Democratic and another to toss-up.
Desmond Bane Gets Emotional About First Return to Memphis
Desmond Bane said returning to Memphis as an opponent made him nervous as he reflected on what the city and Grizzlies still mean to him.
OncoDaily at ESMO 2026: Where Science Meets Community
OncoDaily at ESMO 2026: Where Science Meets Community / Andrea Necchi, Big Questions in Oncology, bladder cancer, esmo 2026, ESMO Congress, healthcare
Where Iowa governor candidates stand on cancer, water, property taxes
Republican Zach Lahn and Democrat Rob Sand are running in Iowa's open governor's race. Here's where they stand on key issues.
Hear Iowa 1st Congressional District candidates on tariffs, Iran war
The marquee U.S. House race in Iowa's 1st District heads for a third rematch, with an independent candidate adding a fresh twist. Meet the candidates.
Steel mill politics will be about predictions, not reality
Two views about Iowa's steel mill plans are emerging, but assessing who's right will take longer than the current campaign, writes Steffen Schmidt.
Can Desmond Bane be Even Better for the Orlando Magic?
Orlando Magic guard Desmond Bane showed last season why trading for him was the right choice, but can he be an even better version of himself in the upcoming season?
Polk County vaccination services at risk under regionalization plan
Polk County health officials painted a somber picture of services at stake while explaining plans by Iowa HHS to regionalize public health.
Iowa health regionalization could put county services in jeopardy
Polk County Health Department could lose an estimated $150,000 as Iowa looks to regionalize health departments for services like infectious disease.
Eco-friendly Highland Park shop finds perfect match in Ingersoll move
The Collective is the latest small business to leave Highland Park, announcing plans to move to a carbon-neutral Ingersoll development.
How watches sparked a friendship between Raggio, Moppert
What began as a business relationship evolved into unlikely friendship built on entrepreneurship, mutual respect and shared fascination with watches.
Dermot Desmond Makes Decision on Martin O'Neill Sacking
Dermot Desmond's stance on sacking Martin O'Neill as Celtic manager has been confirmed.
Verizon gives $1M to Liberty Science Center
Verizon donated $1 million to the Liberty Science Center to expand public access to AI training and tech education
Reform and the UAE – a threat to British politics
By Alex Carlen The United Arab Emirates likes to present itself as part of the solution to the climate crisis. The oil-rich Gulf state has committed to Net Zero by 2050, hosted COP 28, and even declared “championing climate action” as one of three strategic objectives for this week’s session of the United Nations General Assembly. But behind the scenes the UAE has quietly built one of its closest political relationships in Europe with the party most hostile to climate action in Britain: Nigel Farage’s Reform UK. There is no evidence that the UAE is funding Reform. But a new FairSquare report, Petro-populism: the UAE–Reform threat, published today, documents a growing political relationship that should concern anyone interested in the integrity of British democracy. Reform’s leaders have embraced the UAE’s political model and promoted positions that align closely with the Emirati government’s priorities, while the UAE has given Farage and his party unusually warm access and public backing. What is emerging is not simply a relationship between British politicians and a wealthy Gulf state, but a channel through which an authoritarian government can cultivate political influence here, and abroad. Democracy for Sale relies on its readers. If you already support us, thanks so much. If you don’t, sign up to support fearless independent investigative journalism. Subscribe Back in January, Nigel Farage appeared at a GB News event in Dubai. On the 50th floor of a tower overlooking the luxury resorts and upscale residences of Palm Jumeirah, the Reform leader declared: “I want Clacton to look like this.” At the event – which Farage never declared on his official register of interests – senior Emirati officials mixed with British expats. Farage was keen to flatter. “We recognise you are our friends”, he said, assuring them that “a Brexit London, a Reform London, will remember you.” Controversy surrounding Reform’s finances and its susceptibility to foreign influence have centred around high-profile donations from billionaire crypto donors, and the jailing of Nathan Gill, Reform’s former leader in Wales, for accepting bribes to give pro-Russia speeches. Far less attention has been paid to Reform’s blossoming new alliance with the UAE, an oil-rich authoritarian state with a track record of ruinous anti-democratic interventions. Farage wasn’t always so fond of the UAE. Back in 2023 he called it an “absolute monarchy with an abysmal human rights record.” Now Reform’s hierarchy calls the UAE home. Deputy leader Richard Tice splits his time between his constituency and Dubai and has called on the UK to learn from the UAE. The party’s treasurer Nick Candy runs a firm which has been in partnership with a UAE-state linked firm since 2024. Nadhim Zahawi sits on the board of an Abu Dhabi think tank alongside an array of the most senior UAE officials and is reportedly close to three brothers of the country’s despotic ruler Mohammed Bin Zayed. Reform’s leading lights have effusively praised the UAE’s governance model, defended it from criticism, and advanced its political agenda in the UK. GB News, whose two major shareholders – the Legatum Foundation and Paul Marshall – have strong links to the UAE, has been more than happy to broadcast UAE propaganda and was forced to pay damages in 2025 after airing a false claim about a UK charity by the UAE “disinfluencer” Amjad Taha. The UAE has responded in kind. When the UAE Minister for Foreign Affairs conducted an official visit to the UK in May, Farage was the only non-government figure granted an audience. UAE state media publicised the meeting, and said that they discussed “the strategic relations between the two countries and ways to enhance them in a manner that serves mutual interests.” For the UAE these ‘mutual interests’ largely concern its paranoia over political Islam, and in this regard the UAE-Reform alliance is part of a broad and troubling pattern. Following a crackdown on dissent at home in the aftermath of the Arab Spring, the UAE has offered material and political support to a range of violent and authoritarian actors willing to oppose the Muslim Brotherhood with no regard for the consequences. Its meddling in Egypt, Tunisia, Yemen, and most notably Sudan, have been devastating. The UAE’s strategy of seeking out partners on the political fringes who it believes will advance its interests is not unique to Britain – it extends beyond the Middle East to Europe and the US. In France, it has offered clandestine support to Marine Le Pen through secret meetings, as well allegedly funding trips to the region after which Le Pen returned with a renewed focus on the UAE’s perceived enemies – Qatar and the Muslim Brotherhood. Left-wing opposition leader Jean-Luc Mélenchon has accused the UAE of smearing him and of “encouraging discrimination, hatred or violence”. In the US, the UAE actively supported the rise of Donald Trump, establishing itself as a key ally during both his first and second terms. Around these relationships sits a wider ecosystem of figures willing to amplify UAE narratives, that even extends to Andrew Tate and Tommy Robinson. Subscribe In Britain, the UAE has used a combination of aggressive diplomacy and illicit, disruptive tactics to achieve its policy goal of eliminating any perceived threat from political Islam. In 2012, for instance, it threatened to block billion-pound arms deals with the UK and stop inward investment if David Cameron did not act against the Muslim Brotherhood and rein in the BBC’s coverage of the group – going so far as to suggest, with no supporting evidence, that the group had infiltrated the BBC. It has financed smear campaigns against a high-profile UK charity and funded a mercenary to secretly surveil, and possibly assassinate, a British national on British soil. In Reform UK, the UAE has finally found an ally willing to not only ban the Muslim Brotherhood, but to publicly vilify the group and repeat the UAE’s claims that dangerous Muslims are a fifth column in British society, a narrative that aligns with the Islamophobia and anti-immigration sentiments that underpin Reform’s populist politics. The Rycroft review into foreign interference concluded that “hostile states and non-state actors have a clear incentive to attempt to undermine UK democracy.” The UAE’s network and alliance with Reform must be understood within that framework. It is a powerful, disruptive and deeply authoritarian actor with the resources and networks to intervene in our politics, and a track-record of doing so in a multitude of other countries. The evidence of the threat the UAE poses is overwhelming. The question is whether parliamentarians are willing to call the UAE out and demand action using the tools that the government has to respond. Placing the UAE on the “Enhanced Tier” of the Foreign Registration scheme alongside Russia and Iran would send a powerful signal to the UAE that its meddling will no longer be tolerated, and would place Farage’s next trips to the UAE under the scrutiny they deserve. Alex Carlen is research and advocacy manager at London based human rights organisation FairSquare and author of its new report Petro-populism: the UAE–Reform threat. Subscribe
Who better to defend Reform’s latest millions that Honest Bob Jenrick?
The man who once helped Richard ‘Dirty’ Desmond save a load of tax was wheeled out to face Laura Kuenssberg
Gopher Athletics, Learfield’s Gopher Sports Properties, and Visible Bring First-Ever Helmet Bumper Partnership to Minnesota Football
Visible and Gopher Athletics announced a partnership making Visible the first-ever football helmet bumper partner for Minnesota Football.
It's 'Put Up or Shut Up' Time for Orlando Magic
With a new head coach and sharpshooter Desmond Bane on board, Paolo Banchero faces immense pressure to transform Orlando's inconsistent offense into a legitimate Eastern Conference threat.
Can Desmond Bane, Jalen Suggs Thrive With Magic Next Season?
The Orlando Magic need the best version of the Desmond Bane/ Jalen Suggs backcourt next season.
Hampton Social, 30hop among new Waukee Towne Center tenants
Waukee Towne Center has named its first wave of restaurants, stores and entertainment businesses ahead of a planned late-spring 2027 opening.
Why Paolo Banchero Needs to Have an Elite Year
With Desmond Bane joining a revamped roster, Orlando’s franchise centerpiece faces a defining crossroads to silence critics, master his shooting, and elevate the Magic into elite contention.
How AI is quietly reshaping chemical sciences
From reducing administrative workload to navigating ‘alien intelligence,’ this month’s column takes a practical look at integrating LLMs and LWMs in the lab
Scientists made edible cookies out of plastic
This innovation could help address both pollution and hunger. But would you eat one?
As a doctor, I'm fighting in Congress to lower health costs
My time in the U.S. House has been marked by work to make healthcare more affordable, writes Rep. Mariannette Miller-Meeks.
Iowa Senate race a 'toss-up,' governor race 'leans Democrat'
Election analysts at the nonpartisan Cook Political Report moved Iowa's U.S. Senate race into the "toss-up" category, and governor to "lean Democrat."
Rep. Zach Nunn touts bipartisan approach, results in Soapbox speech
Republican U.S. Rep. Zach Nunn highlighted his bipartisan approach to lawmaking, military credentials and legislative results in his Soapbox speech.
See Zach Nunn speak at the Des Moines Register Political Soapbox
Zach Nunn, the Republican candidate for Iowa's 3rd congressional district, takes the stage at the 2026 Des Moines Register Political Soapbox.
Josh Turek talks costs, corruption at Iowa State Fair Political Soapbox
Democratic U.S. Senate nominee Josh Turek kicked off the Des Moines Register's Political Soapbox talking about taking on high costs and corruption.
Desmond Bane on NIL and NBA Expansion
Desmond Bane on his new TCU role, drink launch, and the Magic's season outlook.
Desmond Bane Wants College Basketball to Add a Salary Cap
Bane is TCU’s chief basketball officer.
US move to overhaul science funding prompts some agreement and much doubt
Although researchers agree with the some of the critiques in a new report about the US research system, they are wary of the proposed changes
Lainey Wilson sold out at Iowa State Fair. Which concerts are next?
Iowa State Fair Grandstand concert tickets are selling quick, with one show already sold out. See which acts still have tickets.
Ice Ice Maybe: New Ways to Search for Frozen Water on the Moon
Scientists used a unique vacuum chamber that mimics moon conditions to design an approach for ice prospecting with seismic waves. The work could help future Artemis missions find water.
Can we stop AI from flooding scientific journals?
AI detectors may never beat fraud. Changing how science rewards its researchers might be the only fix that does
Chicago Needs A ‘Small Business Bill Of Rights’ To Reduce Red Tape, Local Leaders Say
Ald. Desmon Yancy is set to introduce a resolution outlining policy goals for the city to lessen regulations, fees and bureaucratic delays for small businesses.
47 revelatory hours with Assassin’s Creed Black Flag Resynced
To review this month’s supposed remake of 2013’s Assassin’s Creed IV: Black Flag, I must first correct the record. Assassin’s Creed Black Flag Resynced isn’t a game about pirates (and assassins) in the 18th century Caribbean. Sure, sure, that’s what the trailers would have you believe. They’ve go their clips of Edward Kenway swinging his swords and steering his pirate ship into cannon-blasting combat against British frigates. Is Resynced truly a pirate game? Of the 47 hours I spent playing Resynced over the past few weeks, I will admit I spent maybe 44 (?) of them collecting plunder with Blackbeard, drinking rum with Anne Bonny and debating the pros and cons of the lawless pirate-run settlement Nassau with Benjamin Hornigold. I may in fact have spent dozens of hours sailing to remote islands, reading treasure maps, opening messages left in bottles, sinking the odd Man o’ War with a well-timed broadside, collecting sea shanties for my crew, befriending a pet monkey, and hunting whales. I am nevertheless neither so Gullible nor so Narrow-Minded as to call the magnificent Resynced a “pirate remake.” Oh no. Forget any reviews of Assassin’s Creed Black Flag Resynced you may have read. Forget what you yourself may have played, if you’ve spent any time with the game since its launch. What Assassin’s Creed Black Flag Resynced is really about I’m here to give you the scoop (spoilers for Resynced’s Animus menu lore, which many players are probably not going to see): Assassin’s Creed Black Flag Resynced, the new game whose development was led by Ubisoft Singapore, is set in the year 2096. It’s about a societal split, about revolution, about an old Assassin’s Creed adventure repurposed in the series’ distant future as propaganda or samizdat. It’s about the overheated future of 2096, essentially conquered by the series’ well-established nefarious Templar-run company Abstergo. (In this future, Abstergo is, among other things, remaking a 2013 pirate movie called Devils of the Caribbean, but this time in VR. The VR version will be backed by a marketing plan that involves AI influencers, a 10,000-avatar “metaverse premiere event” and that manufacturing of memes aimed at “50 million VR nodes.” See what I mean about Abstergo being evil?) Resynced is about a late 21st-century population mollified by the widespread use of Abstergo’s Animus devices which let people experience the lives of historical figures culled from “genetic memories.” It’s about an insurgent faction of Assassins. And it’s about a plan to wake the population into revolutionary fervor by showing them the memories of 18th century pirate Edward Kenway, who—as depicted in the original Black Flag and again in Resynced—gradually comes to an understanding about the Assassins of his day and their centuries old fight for freedom. Resynced is also about an AI developed within the late 21st-century Animus, called Ego. It has found a way to alter genetic memories, to create and show Animus users false ones. The game is about Ego’s efforts to tell the people experiencing Edward Kenway’s memories that Kenway was wrong, that fighting against order is folly, that we should crave a world where “compliance is rewarded with power.” Who are we in this game? We’re an unnamed Animus user in 2096 who experiences Kenway’s journey virtually. At four moments during Kenway’s exploits in the Caribbean our virtual jaunt can be interrupted for 10-15 minutes, as we explore Animus “rifts” where Ego explicitly tries to tell us how wrong Kenway was. None of this is what 2013’s Assassin’s Creed IV: Black Flag was about, of course. That was a different game, even if you also spent dozens of hours pirating as Kenway in that game, across missions and a map that’s been faithfully reintroduced and rebuilt for Resynced. The 2013 Black Flag was about you playing as an unnamed researcher newly hired in 2013 by Abstergo Entertainment, the video game development wing of the Templars’ evil-corp. In that game, you were assigned to use the Animus to dive into the genetic memories of Desmond Miles, a man who died in Assassin’s Creed III and who was descended from a long line of Assassins (and at least one Templar) whose adventures were featured across the prior AC games. In 2013’s Black Flag, your mission was to plumb the Edward Kenway experience for material that Abstergo could use in productions such as the motion picture Devils of the Caribbean, though the Templars had some ulterior motives for the assignment. Resynced is therefore not a remake of 2013’s Black Flag. It’s a sequel. It is a new game about a new exploration of Edward Kenway’s pirate/assassin journey, set 83 years after the framing sequences of the original game. Resynced provides a new narrative framework that, thanks to the concept of an AI that wants to alter historical memories, arrives with creative justification to tweak a now-classic 13-year old game. That makes Resynced, already a hot seller, a tantalizing hint of where Ubisoft could go with a line of Assassin’s Creed remakes. They could remake the first game, the Ezio games, even the recent ones set in ancient Egypt and Greece. And for each, they could not just modernize the graphics and controls but expand and alter their sequences of events to use them as reference points for a conflict set in the late 21st century, as rival factions try to weaponize historical memories. Game File is a reader-supported publication. To receive new posts and support my work, even when that work consists of ravings about Assassin’s Creed’s modern day plot, please consider becoming a free or paid subscriber. Subscribe A story most players will probably miss If you didn’t know any of this, I’m not surprised. If you played the game and still didn’t catch it, I’m not a bit shocked. If Ubisoft has no plans to do more of this, I won’t fall down. Almost all of what I’ve described is optional and missable in Black Flag Resynced. I nearly missed it myself, as I planned for a breezy playthrough of an old Assassin’s Creed favorite. Instead, I found myself in a 40+ hour hunt for the “real” story, buried deeper in Resynced than any gold-filled chest. The story of 2096 is Resynced’s meta-story, told in two remote pockets of the game: 1) four optional playable “rifts” that players may find as they proceed through Resynced’s pirate fantasy , 2) in dozens of text files tucked three menus deep in the game’s barely-interactive Animus hub. Assassin’s Creed games have almost always had a meta-story about people in the 21st century (usually matching the game’s release year) and their connections to the main history portions you play. Those meta-stories have always been squeezed into the margins, though seldom as severely and as, uh, graphiaclly simple, as in recent games. Back in 2013, the modern-day exploits of you as an Abstergo Entertainment employee were prominent. They were portrayed via first-person portions that occasionally interrupted the third-person Kenway experience and could be explored for hours, complete with their own missions, side quests and puzzles. Resynced’s 2096 story—of Assassin “Watchers” vs. Abstergo/Tempar goons, of rogue AIs, of panicking scientists, of a woman wondering why her Animus-addicted husband is muttering about Mary Read (“What does he mean by Assassins?”), of a fight for the population’s hearts and minds via varying interpretations of Edward Kenway’s life choices—is mostly told through unlockable text files. The files are interesting. Offered via diary entries, intercepted chats and news reports, they present varied perspectives of a world in crisis. One set works as a narrative puzzle as it reveals the Rashomonic interpretations of a massacre, or was that a successful Assassin hit? Another favorite reveals the rising bitterness of a person who, through Edward Kenway’s journey, now shakes at the ignored evil around him. One surmises that Ubisoft is averse to putting the Assassin’s Creed’s meta-story in the way of more marketable pirate playgrounds and ninja/samurai epics. Instead, we get a better-than-nothing text-in-menus approach introduced in 2025’s Assassin’s Creed Shadows. In Shadows, players unlocked the meta-story text files largely via time-gated missions that called on the user to kill X number of enemy type Y, clear three enemy castles, re-win a three-phase fighting tournament, and other grinds. Time restrictions on accessing these missions and unlocking the files meant it could take players months to access the full story in-game. But even in the most hardcore Assassin’s Creed hangouts, the fanbase instead seemed to throw up their hands rather than grind to keep up. In Resynced, Ubisoft has shown some mercy, diminishing the amount of new text files that are tied to timed grinds. Now, most of the text-based 2096 lore are associated with “data file” collectibles that players can find in the world. That includes a batch of written entries that explain a historical link between the feudal Japan era in Shadows and the piracy adventures in Black Flag. Players who explore a lot will find dozens of data files, though the game does not appear to offer any in-game tracker for finding each one. You just need to keep looking for them. As of this writing, I have most of them, but not all. I can’t find any full guide for them online. And even Ubisoft’s optional $5 microtransaction that reveals lots of items in-game does not appear to reveal the locations of the text files (at least the official description omits them from its collectibles list). That’s not a huge bother, because tracking the data files down compelled me to re-explore the waves and islands of Black Flag. That was a thoroughly pleasant task to do for the first time in a dozen years. I expect many players, though, will be content to wait for the files to be reproduced in an online AC wiki somewhere, the easier to read on a web page. It may not seem enticing to play a video game in order to gradually unlock pages of text to read. Why not, you may ask, just read a book, where they put the pages in order? For one, they’ve not tucked this latest installment of Assassin’s Creed’s meta saga in a book. I also enjoy the unordered delivery, the dawning comprehension of a story about 2096’s desperate people and questionable tech, which I glimpsed first at its middle, then the end, then the front, then other moments in between1. I am also enamored with the idea of the Assassin’s Creed games I’ve previously played, including Black Flag, being repurposed for an information war. The ideas in Resynced’s meta-story, which builds off characters and ideas in Shadows’ chunks of text, are strong. The potential of where they could go with it is exciting. As for the pirate stuff? Looks great, controls pretty well, is fun to play and oh so speedy in terms of how much of a good time you can have with each sit-down. It never gets old to chase a new shanty page across a rooftop, bombard a fort with upgraded mortars or use a diving bell to explore sunken wrecks (hats off to the team at Ubisoft Barcelona that worked on the underwater portions in Resynced; that team is now facing layoffs, such is the misery of modern gaming and oft-troubled Ubisoft). New pirate missions in Resynced involving new ally characters are brief, dramatic and add more to Edward’s story, even if the gameplay perks they provide barely enhance the gameplay. A new denouement for high-class pirate Stede Bonnet is affecting; a new hunt for Blackbeard’s treasure is a welcome extra moment. A new epilogue to hunt down a pirate killer, on the other hand, over-complicates Kenway’s character. The ending credits remain my favorite of any game I’ve ever played. Black Flag provides great source material. The revisit is well-made and a great sign of what could be. It is offered in a different wrapper that hints at an opportunity for more interesting remakes to come, should Ubisoft choose to pursue such treasures—and as we brace to resist or comply with an Abstergo future. 1 The messages that Edward Kenway finds in bottles tell another out-of-order story, one about a man reckoning with the strange memories and voices he’s heard in his head since he was a boy. That tale was also in the 2013 game and develops into one of Black Flag’s most compelling character arcs. In Resynced, it has lost its climax, because the bottle story previously paid off in the halls of the first-person Abstergo Entertainment, which is exclusive to the older game. An altered resolution, written by the 2013 game’s lead writer is fine, doesn’t invalidate the 2013 version, but makes for an inferior final note.
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