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Who is Nathan Fielder? A guide to his shows including 'The Rehearsal'

Nathan Fielder, who's behind the Elizabeth Holmes doc 'You Can See Everything,' is well-known to comedy fans for his docuseries 'The Rehearsal' and 'Nathan for You.' Here’s a primer on the origin and rise of Fielder.

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Oct 22 • 3:16 PM EDT • Entertainment • latimes.com
Hov's greatest hits: Ranking Jay-Z's best sports references

Jay-Z's catalog is packed with sports references -- here are the ones that top our list.

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Oct 23 • 9:06 AM EDT • Sports • espn.com
Fantasy football waiver wire lookahead: 5 players to stash now
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Oct 24 • 7:03 AM EDT • Sports • sports.yahoo.com
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“Yaga”, “Clayface”, and stop-motion fantasy film “Wildwood ”top this week’s Must List

A “Baby-Sitters Club” podcast and a new stage production of “The Curious Case of Benjamin Button” round out our picks for the weekend of Oct. 23.

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Oct 23 • 3:00 PM EDT • Entertainment • yahoo.com
College GameDay On-Site for Gophers vs Hoosiers

The Minnesota Gophers are coming off a big win over Iowa. And now College GameDay is going with the to Bloomington Saturday for the game @ Indiana.

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Oct 25 • 1:35 PM EDT • Sports • sports.yahoo.com
Fantasy Football injury update: Justin Jefferson cleared for Week 7

Justin Jefferson's ankle was still on the injury report ahead of Week 7.

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Oct 25 • 6:55 AM EDT • Sports • sports.yahoo.com
Mississippi declared infant mortality a public health emergency a year ago. What have officials done since then?

In 2025, an infant mortality report showed Mississippi’s infant mortality rate rose from 8.9 in 2023 to 9.7 in 2024 – nearly twice the national average.

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Oct 23 • 7:00 AM EDT • Health • mississippitoday.org
Actor Tom Skerritt of ‘Steel Magnolias,' 'Top Gun,' dies at 93

NEW YORK — Prolific actor Tom Skerritt died Wednesday from natural causes. He was 93. Skerritf’s “heartbroken” family said, though fans knew him for his work on films including “Alien,”

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Oct 22 • 4:19 PM EDT • Entertainment • recorderonline.com
The Ringer’s Kirk Goldsberry leading Texas athletics’ new AI initiative

Earlier this month, Washington State Athletics received widespread backlash after announcing its partnership with FanWord, an AI-powered storytelling platform. That did not deter the University of Texas. On Friday, Texas athletic director Chris Del Conte announced the launch of Bevo Lab, an AI data analytics platform. “I’m fired up. I’m excited. This is earth-shattering,” Del…

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Oct 23 • 3:45 PM EDT • Sports • sports.yahoo.com
Through pioneers and slow progress, America's relationship to women's sports continues to evolve

LOS ANGELES (AP) — Athletes and fans of women's sports across the United States have found no shortage of reasons to celebrate: historic TV ratings, changing attitudes toward female players, high-profile wins for equal opportunities and pay.

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Oct 22 • 10:18 AM EDT • Sports • wral.com
What We Learned About Gophers in Defensive Showdown vs Iowa

Floyd of Rosedale was on the line Saturday, and the Minnesota Gophers needed their defense to carry the load against Iowa.

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Oct 24 • 8:02 PM EDT • Sports • sports.yahoo.com
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ASUS ProArt P16 review: A sleek showcase for NVIDIA's RTX Spark

NVIDIA's RTX Spark platform is off to a good start, but the ProArt P16 is really only meant for AI fanatics.

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Oct 23 • 8:00 AM EDT • Technology • engadget.com
Week 7 Start 'Em, Sit 'Em Fantasy Quarterbacks

Welcome back, readers!

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Oct 22 • 12:25 PM EDT • Sports • sports.yahoo.com
Angel Reese gets unexpected proposal during historic Finals run

Reese responded after a fan brought a marriage proposal sign to the WNBA Finals as the Atlanta Dream star continued her historic postseason run.

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Oct 24 • 5:31 AM EDT • Sports • sports.yahoo.com
Phillies News: Fan Opinions, Payton Henry, World Series

There’s a game on tonight.

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Oct 23 • 7:00 AM EDT • Sports • sports.yahoo.com
Vikings Release Running Back Ahead of Colts Game

The Minnesota Vikings made a roster move at running back Friday afternoon, two days before hosting the Indianapolis Colts.

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Oct 23 • 7:31 PM EDT • Sports • sports.yahoo.com
Skeleton Festival returns with ghosts, superheroes and family fun

Downtown Harrisonburg was covered with fantasy creatures like dragons, superheroes and princesses Saturday afternoon during the annual Skeleton Festival.

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Oct 25 • 7:00 AM EDT • Entertainment • dnronline.com
NFL fans blast officials for making Sunday Night Football “unwatchable”

NFL fans questioned a controversial roughing-the-passer penalty during the Packers' 23-13 win over the Cowboys on Sunday Night Football. The call erased a potential interception and reignited debate over officiating consistency, player safety and the impact of penalties on the game's flow.

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Oct 23 • 7:45 AM EDT • Sports • sports.yahoo.com
A Boston-marked cone on a Glasgow statue sparks a U.S.-Scotland fundraiser

Scottish fans Andrew Dobbie and Danny Campbell placed a cone marked “Boston” on a Glasgow statue. The viral photo helped inspire a fundraiser for mental health charities

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Oct 23 • 7:30 PM EDT • Health • wcvb.com
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“The View” cancels fan-favorite cohost Halloween costumes for 3rd consecutive year

The show’s panelists previously wore elaborate costumes on the air, ranging from full-body “Avatar” makeup to Carl from “Up!”

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Oct 23 • 12:10 PM EDT • Entertainment • yahoo.com
What Chelsea Did Wrong vs Tottenham

After a stellar run following the international break, things came crashing down for Chelsea as they lost 2-0 to Tottenham Hotspur at the weekend. This marked an extremely rare defeat at Stamford Bridge to the Lilywhites, a crack in a strong record of home wins that has left fans reeling. In this, we will be …

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Oct 25 • 10:54 AM EDT • Sports • sports.yahoo.com
Cowboys fans render a decision on Brian Schottenheimer’s fate

Cowboys fans are pretty upset right now.

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Oct 24 • 6:00 PM EDT • Sports • sports.yahoo.com
Harbaugh Slams Brady’s Return: The Reality Check Giants Need

John Harbaugh doubts Tom Brady can play again, calling the idea a fantasy. Giants fans know the physical toll of the NFL trenches is no joke.

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Oct 24 • 4:16 PM EDT • Sports • sports.yahoo.com
NFL Fans Are Growing More Annoyed With Pat McAfee
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Oct 22 • 12:13 PM EDT • Sports • sports.yahoo.com
Browns Week 7 fantasy start-sit: Boston, Judkins, Fannin, Concepcion

Tennessee has allowed the 10th-most half-PPR points to receivers, while Dylan Sampson’s return from injured reserve threatens Quinshon Judkins’ receiving work.

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Oct 25 • 7:44 AM EDT • Sports • sports.yahoo.com
Another week, another embarrassing fan-player incident. College football appears to have a problem
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Oct 23 • 11:40 AM EDT • Sports • sports.yahoo.com
Understanding Illicit Political Finance to Counter State Threats

In 2024, Western governments warned that Russia was actively interfering in Moldova’s elections, seeking to prevent the re-election of pro-European Union politicians. This interference targeted Moldova’s political system from multiple angles, including covertly funding political actors and protest movements. There were widespread reports of vote-buying, including cash payments of up to €100 to voters. Reports […]

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Oct 23 • 12:01 AM EDT • Politics • thesoufancenter.org
At a Texas high school football game, fans offer a glimpse into evolving politics

We talk with voters at a Texas high school football game at the tailgate, in line at the concession booth and in the stands to hear about the issues that matter to Texans this cycle.

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Oct 23 • 6:35 PM EDT • Politics • npr.org
High-Signal Publisher
Breece Hall questionable for Week 7

Breece Hall's status will need to be watched by fantasy players ahead of Week 7.

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Oct 23 • 4:32 PM EDT • Sports • sports.yahoo.com
Some Buy Telescopes. These People Build Them From Scratch.

For a century, amateur telescope makers have gathered at the Stellafane convention to celebrate their craft. Will the event last another 100 years?

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Oct 24 • 5:00 AM EDT • Science • nytimes.com
Today’s Papers – Lazio fly high, Roma comeback, furious Allegri

La Gazzetta dello SportFantastic draw.Crazy 3-3 between Napoli and Roma. Allegri was sent off; it was a fury.Super hot headLazio, a night as queen: +3 Inter; catching up is on the tableMilan: Cardinal...

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Oct 25 • 4:40 AM EDT • Sports • sports.yahoo.com
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Messi sparks euphoria in Oviedo before Princesa de Asturias award

The Argentinian footballer has arrived in Oviedo with Antonela Roccuzzo, greeting hundreds of fans awaiting him. This Friday he will receive the 2026 Princess of Asturias Award for Sports.View on euronews

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Oct 23 • 1:27 AM EDT • Sports • sports.yahoo.com
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Meet the New Orleans Halloween fanatics sparing no expense to delight or fright, ‘just because’

Come October, these otherwise average homes transform. Spiderwebs shroud the shrubbery. Candles flicker in the windows. Ghosts and ghouls haunt the front porch. These aren’t the kind of households to give out “chump candy.”

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Oct 25 • 5:00 AM EDT • Entertainment • nola.com
Gordon and Barrasso focus on sustainability of Rural Health Transformation Program

CHEYENNE – U.S. Sen. John Barrasso, Wyoming Gov. Mark Gordon and Wyoming Department of Health Director Stefan Johansson held a press conference Friday at the state Capitol to announce the

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Oct 23 • 7:31 PM EDT • Health • wyomingnews.com
Seahawks fan chat: Patriots and Bears kick off Week 7

Before the Patriots got blown out by the Seahawks in Super Bowl 60, they famously got stomped out by the Bears in Super Bowl 20.

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Oct 22 • 7:45 PM EDT • Sports • sports.yahoo.com
I booked a ticket to Bali after I was laid off from my $160,000 job

After a layoff from her$160,000 fintech job, Tiffany Tang traveled through Asia and started DrinkFolks to bring jamu, an Indonesian tonic, to the US.

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Oct 23 • 5:05 AM EDT • Business • businessinsider.com
Fans surpass American Family Field capacity for World Series opener

There were more fans in attendance at American Family Field than the stadium has seats for Game 1 of the World Series.

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Oct 23 • 10:27 PM EDT • Sports • sports.yahoo.com
Mass Effect Fans Call for EA Boycott as Petition to Save BioWare's Canceled Game Garners More than 75,000 Signatures

Mass Effect fans are calling for a boycott of all EA products and services in protest of the company closing down BioWare and canceling the next Mass Effect game.

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Oct 23 • 5:03 PM EDT • Technology • ign.com
Can fantasy managers trust Rhamondre Stevenson tonight?

On paper, Rhamondre Stevenson looks like a safe fantasy bet in Week 7 on Thursday Night Football. Of course, the same could have been said a year ago.

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Oct 22 • 10:01 AM EDT • Sports • sports.yahoo.com
'Avatar: Seven Havens' may have just confirmed a massive fan theory

Seven Havens and seven chakras? That can't be a coincidence.

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Oct 23 • 5:00 AM EDT • Entertainment • mashable.com
FanDuel: Illinois opens as favorite over Maryland

Favorites on the road.

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Oct 25 • 8:27 AM EDT • Sports • sports.yahoo.com
The Leaked Mass Effect 5 Trailer Was Enough To Make Fans Go Feral For One Of Its Sexy, Mysterious Squadmates

We've never had a male Quarian on the team before

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Oct 25 • 8:00 AM EDT • Technology • kotaku.com
Former Coach Urges Vikings to Blow Up Kyler Murray Experiment; Trade for… Kirk Cousins?

Jon Gruden has an insane trade idea for the 5-0 Minnesota Vikings and involves a quarterback change that nobody would see coming...

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Oct 25 • 9:51 AM EDT • Sports • sports.yahoo.com
‘The View’ cancels fan-favorite cohost Halloween costumes for 3rd consecutive year

‘The View’ cohosts will not dress up in Halloween costumes once again in 2026, marking yet another year the panelists won’t participate in the historically fan-favorite episode.

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Oct 23 • 12:10 PM EDT • Entertainment • ew.com
Daniele

Some will say they are called professionals for a reason, because passion is something else. And perhaps that is how it should be: the fans provide the love, while the players simply need to bring pro...

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Oct 25 • 2:00 AM EDT • Sports • sports.yahoo.com
Minnesota Wild Place Young Defenseman on Waivers

The Minnesota Wild made a roster move Friday afternoon, and it involves a young defenseman who has played every game this season.

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Oct 23 • 5:32 PM EDT • Sports • sports.yahoo.com
'Heated Rivalry' made hockey hot. But some fans say the sport's culture is leaving them out in the cold.

"Heated Rivalry" has sparked a hockey mania. But as fans rush to rinks, they also see opportunities for more inclusion.

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Oct 22 • 4:55 PM EDT • Entertainment • yahoo.com
How Connor Hellebuyck Trade Might Hurt/Help MN Wild

The Winnipeg Jets traded Connor Hellebuyck to New Jersey, and the move could ripple all the way to Minnesota.

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Oct 23 • 4:25 PM EDT • Sports • sports.yahoo.com
Fantasy football Week 7 sleepers: 10 streamers to target
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Oct 24 • 7:10 AM EDT • Sports • sports.yahoo.com
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5 Cool Facts About The Ecto-1 Every Ghostbusters Fan Should Know

From its rarity to fun behind-the-scenes details, these are the most interesting facts about the Ecto-1 that every die-hard "Ghostbusters" fan needs to know.

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Oct 24 • 12:25 PM EDT • Technology • jalopnik.com
Buccaneers' Legendary DT Warren Sapp in Hot Water Again

A viral video showing the Hall of Fame defensive tackle kicking a rival fan has reignited scrutiny over his controversial conduct away from the gridiron.

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Oct 22 • 9:51 PM EDT • Sports • sports.yahoo.com
How well have past GOTY winners sold?

We’re less than two months away from 2026’s The Game Awards, and what a year it’s been for fantastic games, including Resident Evil Requiem, Forza Horizon 6, Slay the Spire II, the Blood of Dawnwalker, and Control Resonant – just to name a few. So as we approach the end of the year, we thought we’d look back on our estimates for the GOTY winners of the past four years. In terms of revenue, Elden Ring (2022 winner), Baldur’s Gate 3 (2023), Astro Bot (2024), and Expedition 33 (2025) have generated a combined $3.8B via 73M copies sold: Let’s have a look, then. Elden Ring has generated $2B in revenue Elden Ring is a phenomenon in every sense. It’s sold a whopping 36.4M copies across Steam (50%), PS5 (35%), and Xbox (15% across console and PC). Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Elden Ring also just passed an astronomical milestone: $2B in revenue. While PlayStation and Xbox account for half of Elden Ring’s copies sold across these three platforms, they account for 57.5% of revenue. This – as ever – is due to regional pricing and the higher relative share of PC gamers in lower-priced markets. For example, around 17.4% of Elden Ring’s Steam copies sold were in China, where the game costs about 26% less than the price in the States. There’s an … interesting narrative going around these days that console gamers are only interested in ball-and-gun games and have the patience for little else. Well, Elden Ring’s impressive sales prove that is simply not true, and across all platforms. What’s more, over 9.8M people have played Elden Ring for over 100 hours, with nearly 3.5M people getting all of the achievements and trophies. For reference, 10.9% of Elden Ring’s PlayStation players have the platinum trophy, while 10.5% of players on Steam and 3.9% of Xbox players unlocked all the achievements. Git gud, Xbox players! Of the 1.5M people who played Elden Ring on PlayStation last month, 4% also played Dark Souls 3 last month, 4% played Bloodborne, and 3% played Sekiro. There’s those Soulsborne diehards for you. By many accounts, including my own, Elden Ring is one of the best games of all time. It’s an evergreen seller that will continue to be a cash cow for Bandai and FromSoftware for years to come. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Elden Ring has sold another 2M copies across Steam, PlayStation, and Xbox this year, generating almost $110M. This means it’s outperforming many of this year’s high-profile releases. Even Elden Ring’s standalone run-based PvE spinoff, 2025’s Nightreign, has sold 7.8M copies and generated $282M in revenue. Baldur’s Gate 3 is another billion-dollar-plus banger Another cross-platform phenomenon is Baldur’s Gate 3, which has sold 23.2M copies and generated over $1.2B in revenue. About 18.7M of these copies (80.6%) are via Steam, 2.9M via PS5 (12.7%), and 1.6M (6.8%) via Xbox. Around 1.3M folks on Steam bought BG3 before it hit 1.0. The PlayStation version launched about a month after the PC 1.0 release, while the Xbox version came four months later due to technical issues around developing local co-op on the Series S. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Across platforms, Baldur’s Gate 3’s monthly active users have never dropped below 2M, including 2.2M MAUs last month (68.5% on Steam, 21.9% on PS5, and 9.6% on Xbox). And it still regularly brings in 280K to 400K players every day: About 1% of BG3’s Steam player base has played for over 500 hours! That’s a little under 200K people. Astro Bot is also an evergreen seller, albeit a more niche, family one Astro Bot, 2024’s winner, has now sold 4.7M copies and generated $291M in revenue. The budget, including marketing, is almost certainly under $100M, given the small Japan-based core team and three-year dev timeline. You can really see why the tides are changing toward less expensive hubs. Astro Bot is the only first-party winner on this list, but follows other first-party winners of The Last of Us Part II (2020’s winner), God of War (2018), and Breath of the Wild (2017). Around 46.6% of Astro Bot’s copies sold have been physical, which is far higher than the typical game. This makes sense for a couple of reasons: There’s a large family audience for this one, and physical boxes are an item to wrap when giving Astro as a gift. Astro has collector value for the PlayStation core (this is nostalgia-fueled platformer celebrating PlayStation’s history) Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Astro is another one of those games that continues selling over time, regularly selling more than 100K a month. It’s sold around 1M more copies this year ($60M in revenue) and is a popular title with families. We can see this using the Alinea platform’s MAU crossover tool: Astro Bot’s top #2, #3, and #4 games by crossover in any given month this year are Minecraft, Fortnite, and Roblox – without fail. The #1 title every month, though, is Astro’s Playroom, a pack-in with all PS5 consoles. For every month this year, between 20% and 30% of Astro Bot players also played Astro’s Playroom that month. So the free pack-in is a noice funnel for converting players to a full paid product. Expedition 33 sells 8.7M despite Game Pass cannibalisation Finally, we have last year’s winner – Expedition 33. The turn-based-RPG banger has generated $366M via 8.7M copies sold, with 58.8% on Steam, 35.7% on PS5, and 5.5% on Xbox. Xbox’s share of copies sold is this low due to Expedition 33 launching on Game Pass, where 4.3M people across console and PC accessed the game. A little under 700K Xbox players used their subscription to play Expedition 33 this year. That said, the game’s 1.5-year Game Pass deal ended last week on October 16, and we’re already beginning to see a positive trend on Expedition 33’s copies sold via Xbox (but the jury’s still out!). There’s understandably a lot of French pride behind this one, as France is the game’s #3 market on both Steam and PlayStation. Vive la France! One thing that stood out to me is that the GOTY winners aren’t $300M Hollywood productions made in the US. They’re mostly mid-budget studios outside the traditional AAA cost centres. Lots to think about there. Also, good games sell well; who’d have thunk it!? And there’s a whole load of them this year, with GTA 6 still to come, too. GTA just made the cutoff point for the VGAs this year. What a coincidence! Loading... Cool links and other stuff Our physical games newsletter from Tuesday was picked up by GameSpot, Eurogamer, TweakTown, and a bunch of others. We’re offering a free trial of our platform for games companies. Send us a message here, or reply right here on Substack/email, and we’ll set you up. Next week, we’ve got some exciting news regarding the future of our newsletter, so stay tuned! The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. Want to see why these companies (and many others) are subscribed to Alinea? Get a free platform trial! [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]

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Oct 22 • 1:02 PM EDT • Technology • alineaanalytics.substack.com
Bronze Siskel & Ebert statue, with their theater seats, coming to Prudential Plaza

The sculpture will invite fans of Chicago's most celebrated film critics to sit in their iconic theater balcony seats.

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Oct 22 • 9:15 AM EDT • Business • chicagobusiness.com
LEGO Ideas Build, Paint and Play! (40889) Officially Announced

LEGO has officially revealed a new gift with purchase set that will be coming out next week with the LEGO Ideas Build, Paint and Play! (40889). Releasing on October 28, the set has 158 pieces and will require a $130 general purchase on the LEGO Shop or in stores. The set was the winning build from t

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Oct 22 • 8:00 PM EDT • Technology • thebrickfan.com
Mass Effect Spiritual Successor Officially Reveals Redesigned Protagonist

Exodus reintroduces Jun following fan feedback

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Oct 23 • 10:05 AM EDT • Technology • polygon.com
FINAL FANTASY RESONANCE is a Delightful Return to the Series' Classic Roots

FINAL FANTASY RESONANCE is an HD-2D love letter to the classic series, available now on XBOX. Read our hands-on impressions:

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Oct 22 • 12:00 PM EDT • Technology • news.xbox.com
Promising Sci-Fi RPG Exodus Changes Its Main Character's Face After Fan Criticism

Mugged

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Oct 22 • 2:00 PM EDT • Technology • pushsquare.com
Pasadena Apple Store draws crowds as iPhone Duo launches worldwide

Apple fans lined up around the block at the Pasadena Apple Store on Friday as Apple officially launched the new iPhone Duo, the company's first foldable smartphone.

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Oct 23 • 10:53 AM EDT • Technology • abc7.com
The one thing Donna Mills refuses to do on her OnlyFans page

Donna Mills, 85, explains what she refuses to do on her OnlyFans page

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Oct 24 • 6:15 PM EDT • Entertainment • ew.com
Fantasy football start-sit Week 7: Rhamondre Stevenson, TreVeyon Henderson

Some start or sit advice for Patriots RB's Rhamondre Stevenson and TreVeyon Henderson.

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Oct 22 • 10:39 AM EDT • Sports • sports.yahoo.com
Petition to "Save Mass Effect" reaches over 170k signatures as fans plan billboard outside EA HQ

The Mass Effect community is not going down without a fight

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Oct 25 • 9:00 AM EDT • Technology • windowscentral.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
😱Fans back Carrick: How the United players left

Today, Manchester United suffered another crushing defeat, losing 0-3 to Bournemouth at Old Trafford. There was plenty of talk during the week about the rift between the players and Michael Carrick, p...

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Oct 25 • 12:44 PM EDT • Sports • sports.yahoo.com
Excited Apple fans camp outside stores ahead of new iPhone Duo release

Apple's first foldable device goes on sale in just hours.

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Oct 23 • 6:05 AM EDT • Technology • 6abc.com
G-Shock's Affordable "CasiOak" Successor Is Here, and It Looks a Lot Like Another Bucket-List Sports Watch

G-Shock says the 2500 series takes after its original 1983 octagonal watch. Some excited fans are convinced about another horological icon.

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Oct 22 • 12:56 PM EDT • Technology • gearpatrol.com
Houston Comets on TV: WNBA games will be on KHOU, KTBU, Space City

Good news for WNBA fans: You won't have to subscribe to a streaming service or even have cable to watch Houston Comets games when they return to play next year.

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Oct 22 • 5:05 PM EDT • Entertainment • houstonchronicle.com
Liverpool working towards deal for star; could reach €90m

Liverpool are reportedly in the mix for a very in-demand France star. They’re working towards a deal and it’s one that could cost €90m.Liverpool are weighing up their transfer targets for the up...

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Oct 25 • 4:10 PM EDT • Sports • sports.yahoo.com
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Video: Brewers Stadium Erupts After Jacob Misiorowski’s 1st World Series Strike Out

Jacob Misiorowski did not have to wait long to feel the energy of the World Series. The Milwaukee Brewers right-hander recorded his first strikeout on baseball’s biggest stage Friday night, and the reaction from the crowd at American Family Field said everything about what the moment meant to Brewers fans. A video of the strikeout [...]

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Oct 23 • 10:34 PM EDT • Sports • sports.yahoo.com
Gamethread: Panthers @ Penguins

Talk about the game with Pens fans here!

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Oct 22 • 6:45 PM EDT • Sports • sports.yahoo.com
MN Wild in “Very Positive” Talks with DirecTV

Michael Russo dropped a hint Saturday morning that could matter to a lot of MN Wild fans. Here is what he said about DirecTV and where things stand with Wild+.

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Oct 24 • 12:50 PM EDT • Sports • sports.yahoo.com
Five Science Fiction Movies to Stream Now

In this month’s picks, alien encounters, sinister deepfakes, fantastical time loops and postapocalyptic woe.

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Oct 23 • 11:00 AM EDT • Science • nytimes.com
LIVE! Watch UFC 333 Post-Fight Presser

With UFC 333 officially a wrap after an entertaining card earlier today (Sat., Oct. 24, 2026) LIVE on Paramount+ from inside Etihad Arena in Abu Dhabi, United Arab Emirates, fight fans can now check out the post-fight press conference video above for all the best reaction and official bonus winners. On a day that featured […]

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Oct 24 • 4:00 PM EDT • Sports • sports.yahoo.com
Liverpool Injury News: Szoboszlai, Munoz, and Frimpong Latest

Liverpool fans have been provided with a series of fitness updates following the team's pre-Brighton training session this morning. Multiple players face a race against time to be fit for the weekend's Premier League clash, with others set for longer layoffs.

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Oct 22 • 8:29 AM EDT • Sports • sports.yahoo.com
Democrat running for Stefanik's seat says 'my identity is not in politics'

Upstate New York congressional candidate Blake Gendebien (D) joins Meet the Press NOW to discuss his campaign in New York's North Country and where his priorities fit into the Democratic Party's agenda.

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Oct 22 • 4:59 PM EDT • Politics • nbcnews.com
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Poll: If You're Playing Modern Warfare 4, What Do You Think So Far?

Are you a fan? And if not, what's stopping you?

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Oct 24 • 11:00 AM EDT • Technology • purexbox.com
Downtown Sacramento businesses prepare for crowds ahead of Kings home opener

A new team store, Kings-themed drinks and game-day discounts are among the offerings available to fans near Golden 1 Center.

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Oct 22 • 10:02 PM EDT • Business • kcra.com
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World Series in Milwaukee impacts high school sports, Bucks home opener

High school football and the Milwaukee Bucks are making changes to accommodate the Brewers and sports fans.

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Oct 23 • 12:01 PM EDT • Sports • wsaw.com
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"If they are Nuggets fans, they should support us," …

"If they are Nuggets fans, they should support us," …

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Oct 25 • 5:27 AM EDT • Sports • sports.yahoo.com
Hailee Steinfeld releases new song 'Magic' from 'Hexed'

Hailee Steinfeld at the Disney Entertainment Showcase at D23: The Ultimate Disney Fan Event on Aug. 14, 2026, in Anaheim, Calif. (Matt Winkelmeyer/Getty Images for Disney, FILE)

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Oct 23 • 4:00 PM EDT • Entertainment • kmaland.com
Fantasy football Week 7: Should you start Baker Mayfield?

Should you start Baker Mayfield against Carolina in Week 7? Here's his fantasy production, injury outlook and matchup analysis.

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Oct 24 • 4:45 PM EDT • Sports • sports.yahoo.com
Steelers fan event in Paris cancelled by NFL

Steelers event in Paris gets canceled

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Oct 22 • 11:13 AM EDT • Sports • sports.yahoo.com
Liverpool and Man United contacted about transfer of wonderkid

Liverpool have a fair few positions among their ranks that still need to be upgraded. The Anfield outfit have fallen behind their title rivals quite dramatically recently with most of their players fa...

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Oct 25 • 6:10 AM EDT • Sports • sports.yahoo.com
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Baker Mayfield Returns To Practice, Diminishes Jalon Daniels' Fantasy Outlook

The Tampa Bay Buccaneers welcomed star quarterback Baker Mayfield back to practice on Wednesday following a three-game absence due to injury.

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Oct 22 • 12:11 PM EDT • Sports • sports.yahoo.com
NFL cancels Steelers Fan House event in Paris
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Oct 22 • 9:43 AM EDT • Sports • sports.yahoo.com
Tiffany announces parental 'Bill of Rights' to ban transgender sports, pronoun changes

Republican candidate for governor Tom Tiffany says he’ll make Wisconsin schools more accountable by giving parents and teachers more rights.

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Oct 22 • 4:32 PM EDT • Sports • wpr.org
Week 7 Fantasy Football Rankings: TE, K, DEF
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Oct 22 • 11:38 AM EDT • Sports • sports.yahoo.com
Joel Klatt says Big Ten-SEC football challenge is imminent

The Big Ten and SEC run college football, but as the sport tries to chart its future, the two sides haven’t found much in common. Until now? After an exhausting period of negotiations, brinksmanship, and fan unrest, college football is moving towards a 24-team College Football Playoff. The Big Ten had held out against the…

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Oct 22 • 11:30 AM EDT • Sports • sports.yahoo.com
17 Celebrity Transformations That Left Fans Doing A Double Take

From Avril Lavigne's “soft makeup era” to JoJo Siwa’s “clean girl” aesthetic, these wild celebrity transformations will leave you gagged.

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Oct 25 • 10:00 AM EDT • Entertainment • yahoo.com
Week 7 Fantasy Football RB Rankings
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Oct 23 • 1:01 PM EDT • Sports • sports.yahoo.com
Rumored Lucia Actress Goes Viral After Dodging Swarm of GTA 6 Comments During Livestream

Manni L. Perez, the actress long rumored to be playing Lucia in GTA 6, has gone viral after dodging a swarm of comments from Grand Theft Auto fans during a recent livestream.

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Oct 25 • 11:14 AM EDT • Technology • ign.com
Three giant black holes discovered in a galaxy from the dawn of time

Astronomers have discovered three actively feeding black holes inside a single galaxy more than 12.5 billion light-years away, revealing a remarkable scene from the universe’s infancy. Two of the black holes are separated by just 620 light-years and are expected to eventually merge, while a third lurks farther away. One weighs an astonishing 80 million suns, and another is growing faster than conventional theories predict.

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Oct 25 • 8:00 AM EDT • Science • sciencedaily.com
Apple’s $2,000 foldable iPhone launches amid strong demand

SYDNEY/SHANGHAI/LONDON >> Apple’s first folding phone, the iPhone Duo, hit stores around the world today with a price tag of about $2,000 and less of the fanfare that accompanied previous iPhone launches.

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Oct 23 • 7:20 PM EDT • Technology • staradvertiser.com
Which college football team is the biggest disappointment of 2026?

Some of college football's biggest preseason contenders have stumbled ... hard. From Texas to Texas A&M and beyond, we want fans to name the biggest disappointment of 2026.

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Oct 22 • 6:00 AM EDT • Sports • sports.yahoo.com
When the MAGA's over: Nostalgia sets in for Trump fans at final rallies
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Oct 23 • 11:33 PM EDT • Politics • yahoo.com
Fantasy Football Week 7 Deep-Sleepers: Bam Knight, Caleb Douglas, and 3 Others

Bam Knight and Caleb Douglas are two of five total deep-sleepers to pick up and start in Week 7 fantasy football.

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Oct 24 • 9:47 AM EDT • Sports • sports.yahoo.com
Through Pioneers and Slow Progress, America's Relationship to Women's Sports Continues to Evolve

LOS ANGELES (AP) — Athletes and fans of women's sports across the United States have found no shortage of reasons to celebrate: historic TV ratings, changing attitudes toward female players, high-profile wins for equal opportunities and pay. After decades of disparity and sometimes outright scorn ...

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Oct 22 • 10:13 AM EDT • Sports • usnews.com
Vikings Scouting: Texas WR Cam Coleman

Should fans be worrid about Cam Coleman's average production?

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Oct 24 • 7:00 AM EDT • Sports • sports.yahoo.com
Heidi Klum frightens fans, teases Halloween costume with bizarre close-up of strange prosthetic

The Queen of Halloween herself Heidi Klum is offering fans a first look at this year’s Halloween costume. As usual, it involves some pretty bizarre prosthetics.

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Oct 25 • 2:37 PM EDT • Entertainment • ew.com
What is the latest on Carson Beck’s back injury status?

GLENDALE – Even though he is listed as the third QB on the depth chart, the injury to Carson Beck is stirring up some worries for Cardinals fans who are eager to see him get an opportunity. How serious is the new back injury that Beck is dealing with? Oct 4, 2026; East Rutherford, New Jersey, USA; Arizona Cardinals quarterback Carson Beck (19) warms up before the game at MetLife Stadium.

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Oct 24 • 2:53 PM EDT • Sports • sports.yahoo.com
Liverpool committing to Barcelona model, massive change for club

Liverpool are committing to the Barcelona model. It's a massive change for the club - but will it pay off?Liverpool have a transfer strategy under Jurgen Klopp and it was a wildly successful one. They...

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Oct 25 • 4:40 AM EDT • Sports • sports.yahoo.com
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