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Epstein files take back seat in midterms but experts say issue has not gone away

Other voter concerns have prevailed but return of Congress likely to see renewed focus on late sex offender’s activities

theguardian.com logo
Oct 24 • 8:00 AM EDT • Politics • theguardian.com
My mother donated her body to science. I really wasn’t prepared for what came next

The process included a gala featuring medical students doing aerial yoga and singing Taylor Swift to donors’ families. In some way, it was absolutely perfect

theguardian.com logo
Oct 24 • 8:00 AM EDT • Science • theguardian.com
'The church has ceded the commanding heights of science': New Trinity…

Huntsville could soon be home to a groundbreaking Christian liberal arts college focused on preparing students for careers in Science, Technology,…

1819news.com logo
Oct 24 • 8:00 PM EDT • Science • 1819news.com
Readers Write: Book bans, health care reform, Ilhan Omar raid

When you side with censors, you’re wrong.

startribune.com logo
Oct 24 • 2:28 PM EDT • Health • startribune.com
Connections: Sports Edition today: Hints and answers for Oct. 25, 2026, puzzle No. 762

Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.

nytimes.com logo
Oct 25 • 12:00 AM EDT • Sports • nytimes.com
Google Health 5.11 rolling out expanded 100+ activity detection to Fitbit Air, Pixel Watch

Google Health previewed improved automatic activity tracking, and it’s now beginning to roll out with version 5.11 of the app.

9to5google.com logo
Oct 23 • 2:36 PM EDT • Technology • 9to5google.com
SpaceX's Launch Business Wasn't Profitable Last Quarter, but Here's the Hidden Upside

The space segment is doing more for SpaceX than its raw revenue numbers indicate.

fool.com logo
Oct 23 • 11:34 AM EDT • Business • fool.com
Americans agree on health care costs. Why can't Congress act?

Opinion: Patients need health care relief they can actually feel.

cincinnati.com logo
Oct 24 • 12:30 AM EDT • Health • cincinnati.com
New Mass Effect 5 Leak Explains How It Was Going To Deal With Mass Effect 3's Multiple Endings

The game would have supposedly used time and distance to fit its story into every decision Shepard could have made

kotaku.com logo
Oct 23 • 1:22 PM EDT • Technology • kotaku.com
Does mouth taping actually work? What the science says about this viral sleep trend

Mouth tape is trending for snoring, but research suggests limited benefits and potentially serious risks for people with breathing problems.

newsobserver.com logo
Oct 24 • 9:00 AM EDT • Science • newsobserver.com
Payroll Delay Unnerves Staff at Randolph Health

Payroll for Randolph Health's roughly 800 employees did not arrive Friday, amid concerns about the finances of its for-profit owner.

theassemblync.com logo
Oct 23 • 5:08 PM EDT • Health • theassemblync.com
How to build a police state

To understand where Trump is trying to take the US, we should look to the authoritarian playbook of his favorite ally: El Salvador’s Nayib Bukele

theguardian.com logo
Oct 25 • 9:00 AM EDT • Politics • theguardian.com
The boss whose twice-bust business appears to be back despite £3m debts

Andrew Woosnam took millions from his companies before leaving creditors including HMRC out of pocket

theguardian.com logo
Oct 25 • 5:00 AM EDT • Business • theguardian.com
What gets fact-checked? How politics shapes the answer in four African countries

Many fact-checkers are moving away from declaring claims as true or false, and trying to help people judge information for themselves.

theconversation.com logo
Oct 25 • 2:10 AM EDT • Politics • theconversation.com
Bernie Sanders backs Amanda Janoo's health plan

Bernie Sanders joined gubernatorial candidate Amanda Janoo in Winooski to endorse her plan for free universal primary care in Vermont.

vnews.com logo
Oct 25 • 8:01 AM EDT • Health • vnews.com
Health insurance costs keep climbing for American workers, a new survey finds

The 2026 Employer Health Benefits Survey, released Thursday, found that covered workers were paying hundreds of dollars more toward their premiums this year compared with last year.

6abc.com logo
Oct 24 • 12:52 PM EDT • Health • 6abc.com
Additional 178 cases of measles reported by US health authorities amid outbreak

Centers for Disease Control and Prevention reported 4,588 cases across the country, more than double the tally in 2025

theguardian.com logo
Oct 24 • 8:00 AM EDT • Health • theguardian.com
ESPN Floats Vita Vea as a Lions Deadline Sleeper

An ESPN insider floated Vita Vea as a Lions deadline fit. The catch is next year's money. #OnePride

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Oct 23 • 12:15 PM EDT • Sports • sports.yahoo.com
‘Talking to every single person matters’: ‘prairie populists’ canvass the rural US heartland to win in midterms

Democratic and independent candidates stump the US midwest and prairie states, hoping to win over Republican strongholds

theguardian.com logo
Oct 25 • 6:00 AM EDT • Politics • theguardian.com
World's Fastest Lawnmower Company Is Officially Going Out Of Business

Dixie Chopper made the world's raddest lawnmowers for almost half a century, but its story is now coming to an end.

carbuzz.com logo
Oct 25 • 10:30 AM EDT • Business • carbuzz.com
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The Health Benefits of Blueberries—and the Best Ways to Eat Them

Are blueberries good for you? Experts share the health benefits of these popular berries. Plus, discover what to look for when buying blueberries, the best way to store them, and how to use blueberries in your food and cooking.

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Oct 25 • 8:00 AM EDT • Health • marthastewart.com
Reducing drug harm in NC mountain counties

Needle exchanges, disease testing, providing Narcan and other harm reduction efforts navigate complexities of Western NC communities.

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Oct 25 • 4:00 AM EDT • Health • northcarolinahealthnews.org
Nonprofit organizes ‘silkies’ hike to support military members’ mental health

Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.

wpxi.com logo
Oct 25 • 11:27 AM EDT • Health • wpxi.com
The vulnerable House Republican trying to withstand the anger directed at his party

GOP Rep. Brian Fitzpatrick was weaving through the crowd of a fall street festival when he was confronted by a man enraged by the skyrocketing costs he’s experiencing.

cnn.com logo
Oct 24 • 6:30 AM EDT • Politics • cnn.com
Los Angeles health authorities report 2nd second rabies-positive raccoon

In a follow-up on the report a rabies-positive raccoon found in Los Angeles County, the first in more than 5 decades, the LA County Department of Public Health is investigating a second rabies-positive raccoon found in the Westlake Village area of Los Angeles County. Public Health has confirmed that the first raccoon was positive for a variant of rabies typically found in bats. Strain testing for the second raccoon is currently pending. The second rabid raccoon was found in a backyard in the vicinity of where the first raccoon was reported and appeared sick and aggressive. No residents or pets were exposed to the raccoon. Two people at a worksite may have been exposed to the raccoon and are receiving recommended follow-up for rabies post-exposure prophylaxis. The World’s Deadliest Viruses Prior to these detections, the last confirmed rabid raccoon in Los Angeles County was detected in 1973, when the skunk variant (strain) of rabies was still present in the County. That strain has not been detected in Los Angeles County since 1979. In 2014, a skunk infected with the bat variant of rabies was detected in Long Beach. “The detection of rabies in another raccoon is an important reminder to never touch, handle, or feed any wild animals, even when they appear healthy,” said Muntu Davis, MD, MPH, Los Angeles County Health Officer. “Always keep a safe distance from wildlife and contact your local animal control if you encounter an animal that appears to be sick, injured, or behaving unusually. It is also critical to ensure your pets are up to date on rabies vaccination so they are protected before any potential exposure. Keeping your pets vaccinated is one of the most important steps you can take to protect your entire family.” Outbreak News Today is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe

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Oct 24 • 5:01 PM EDT • Health • outbreaknewstoday.substack.com
Health insurance costs keep climbing for American workers, a new survey finds

The 2026 Employer Health Benefits Survey, released Thursday, found that covered workers were paying hundreds of dollars more toward their premiums this year compared with last year.

abc7.com logo
Oct 24 • 12:52 PM EDT • Health • abc7.com
Health board still paying for research despite criticism over patient benefit

Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.

nz.news.yahoo.com logo
Oct 25 • 9:31 AM EDT • Health • nz.news.yahoo.com
Just two drinks a day may be far riskier than you think

A major new study reveals that drinking just two alcoholic beverages a day is associated with a 1 in 25 lifetime risk of death from alcohol-related causes, challenging the idea that moderate drinking is harmless. Researchers also found no significant overall health benefits from alcohol, with risks rising as consumption increases.

sciencedaily.com logo
Oct 25 • 8:00 AM EDT • Science • sciencedaily.com
Rubio tells Cubans ‘now is the time’ to act to see political change

US secretary of state makes comments after Trump tells US rally warships could intervene on return from Iran

theguardian.com logo
Oct 23 • 8:30 PM EDT • Politics • theguardian.com
As a divided Israel prepares to go to the polls, can Netanyahu pull off his greatest political trick yet?

The prime minister has defined and dominated his country’s politics for three decades and is putting his rivals on the defensive before Tuesday’s general election

theguardian.com logo
Oct 24 • 1:00 AM EDT • Politics • theguardian.com
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'Super Mario' Creator Breaks Down The Problem With AI Perfectly

Nintendo's Shigeru Miyamoto, known for Zelda and Mario, just gave the world a master class on the limits of AI creation

polygon.com logo
Oct 24 • 6:13 AM EDT • Technology • polygon.com
A last-minute voter guide to all 14 propositions on the California ballot

Californians are voting on 14 ballot measures, including propositions on taxes, voting, healthcare, housing and the environment. It's a lot to take in, but we're here to help.

calmatters.org logo
Oct 25 • 9:00 AM EDT • Politics • calmatters.org
Why ultra-Orthodox parties hold so much sway in Israeli politics

Ultra-Orthodox Jews, often called Haredim, make up a small but growing percentage of Israel’s population. Still, their political parties wield significant influence.

theconversation.com logo
Oct 23 • 10:52 AM EDT • Politics • theconversation.com
Laramie County health and food inspections (10/16/26–10/22/26)

CHEYENNE, Wyo. — The Cheyenne-Laramie County Health Department inspects restaurants, bars, convenience stores, delis, grocery stores, bed and breakfasts

capcity.news logo
Oct 25 • 11:00 AM EDT • Health • capcity.news
Natrona County health and food inspections (10/16/26–10/22/26)

CASPER, Wyo. — The Casper-Natrona County Health Department inspects restaurants, grocery stores, convenience stores, mobile food units, commissaries and

oilcity.news logo
Oct 25 • 11:00 AM EDT • Health • oilcity.news
More than 350 suburban homes benefit from program targeting lead and other health risks

Improving energy efficiency is also called an important goal of the program as Chicago faces more severe weather events.

chicagotribune.com logo
Oct 23 • 12:00 PM EDT • Health • chicagotribune.com
How LaLiga Turned a Global Soccer Brand Into an $87 Million U.S. Business

LaLiga’s successful expansion into North America shows how to turn a global sports brand into a sustainable business.

inc.com logo
Oct 25 • 9:00 AM EDT • Business • inc.com
Addressing mental health and loneliness through art: LaunchSpace's SocialRx program gets United Way funding support

LaunchSpace's SocialRx program received a $75,000 grant from the United Way of Franklin & Hampshire Region to boost regional wellness.

recorder.com logo
Oct 24 • 6:00 PM EDT • Health • recorder.com
Google Health Update to 5.11 Brings Several Huge Upgrades

A new version of Google Health is rolling out as version 5.11 on both Android and iOS. This fresh build brings numerous changes, like Health Guardian features for the Fitbit Air. It also greatly improves automatic activity tracking, gives more options for glucose tracking, and has improved sleep tracking. Even though we are only jumping...

droid-life.com logo
Oct 23 • 4:31 PM EDT • Technology • droid-life.com
The biggest political donors in Minnesota races this election season

Many of the ads now appearing on TV and social media are funded by a web of political committees and major donors whose connections are often difficult to trace.

startribune.com logo
Oct 24 • 7:00 AM EDT • Politics • startribune.com
Culture House Wants to Turn Creator Connections Into Lasting Businesses

Culture House connects creators directly with investors and operators, helping turn cultural influence into sustainable businesses.

inc.com logo
Oct 25 • 10:00 AM EDT • Business • inc.com
Made in Tarrant: Family turns sports card hobby into baseball stadium business

Rebecca Gallagher and her family opened their business in Choctaw Stadium in Arlington a few weeks ago. They hope it can grow into a place for community.

fortworthreport.org logo
Oct 25 • 2:00 PM EDT • Business • fortworthreport.org
Newtown Health Fair Educates And Supports Community

On October 10, the 31st Newtown Health Fair was held at Newtown Community Center. Scores of guests attended. Flu shots were provided for those who wanted them by Housatonic Valley Health District, and...

newtownbee.com logo
Oct 24 • 3:00 AM EDT • Health • newtownbee.com
France’s Protests Are a Warning for America

Riots often benefit the political right.

slate.com logo
Oct 24 • 5:40 AM EDT • Politics • slate.com
Why crafting is good for your brain, according to science

Knitters and other crafters say busy hands quiet their minds. But experts say there are also benefits for cognition.

washingtonpost.com logo
Oct 25 • 5:00 AM EDT • Science • washingtonpost.com
VIDEO: Shop Local at the RI Small Business Village at Providence…

GoLocalProv.com is the “go to” local Web experience that breaks the biggest local stories – sports, news, business, weather, news, politics, arts,…

golocalprov.com logo
Oct 24 • 2:25 AM EDT • Business • golocalprov.com
Just two drinks a day may be far riskier than you think

A major new study reveals that drinking just two alcoholic beverages a day is associated with a 1 in 25 lifetime risk of death from alcohol-related causes, challenging the idea that moderate drinking is harmless. Researchers also found no significant overall health benefits from alcohol, with risks rising as consumption increases.

sciencedaily.com logo
Oct 25 • 8:00 AM EDT • Health • sciencedaily.com
Membership Benefits: Austin Clubhouse’s mental health support goes beyond clinical care

The community helps people with mental health conditions to rediscover their self worth.

austinfreepress.org logo
Oct 23 • 11:42 AM EDT • Health • austinfreepress.org
Stories to cover as insurance costs continue to outpace wages, inflation

This year, U.S. workers are once again facing rising health insurance costs, continuing a trend that has persisted for decades, according to KFF’s 2026 Employer Health Benefits Survey, published yesterday, Oct. 22.

healthjournalism.org logo
Oct 23 • 4:13 PM EDT • Health • healthjournalism.org
"This was not a Creative Assembly developed game": Total War boss points the finger at external partner for Shogun 2 Complete Edition disaster

"We are a craft studio": Creative Assembly clarify that they don't AI-generate art following Shogun 2 CE disaster, and are "investigating" an external partner.

rockpapershotgun.com logo
Oct 23 • 12:01 PM EDT • Technology • rockpapershotgun.com
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean

Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...

finance.yahoo.com logo
Oct 25 • 10:08 AM EDT • Health • finance.yahoo.com
Connections: Sports Edition today: Hints and answers for Oct. 24, 2026, puzzle No. 761

Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.

nytimes.com logo
Oct 24 • 12:00 AM EDT • Sports • nytimes.com
Likelihood Each Cubs Free Agent Starter Returns

From Shota Imanaga’s uncertain future to Clay Holmes’ defensive fit, we breakdown the odds of Chicago’s veteran rotation arms returning to the North Side for 2027.

sports.yahoo.com logo
Oct 24 • 5:50 PM EDT • Sports • sports.yahoo.com
Made in Tarrant: Family turns sports card hobby into baseball stadium business

Rebecca Gallagher and her family opened their business in Choctaw Stadium in Arlington a few weeks ago. They hope it can grow into a place for community.

fortworthreport.org logo
Oct 25 • 2:00 PM EDT • Sports • fortworthreport.org
The World Series of the have-nots is here. But baseball’s money problem isn’t going away

Baseball’s two best regular-season teams are also among its lowest spenders. But their unlikely World Series comes with a warning about the sport’s future

theguardian.com logo
Oct 24 • 11:01 AM EDT • Sports • theguardian.com
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Xbox's first chief operating officer Helen Chiang leaves Microsoft just three months into the job

Helen Chiang is leaving Microsoft just three months after becoming Xbox's first chief operating officer, according to a memo from CEO Asha Sharma.

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Oct 24 • 8:57 AM EDT • Technology • eurogamer.net
Campbell County health and food inspections (10/16/26–10/22/26)

GILLETTE, Wyo. — The Consumer Health Services Division of the Wyoming Department of Agriculture conducts inspections of retail food establishments throughout Wyoming (where there is not a local health department that does inspections) to help ensure safety of Wyoming residents. Campbell County establishments are inspected at least once a year by the WDA. All of […]

county17.com logo
Oct 25 • 11:00 AM EDT • Health • county17.com
Nonprofit organizes ‘silkies’ hike to support military members’ mental health

During the hike, participants wore military short-shorts known as “silkies” as part of the event’s tradition to foster connection.

wpxi.com logo
Oct 25 • 11:27 AM EDT • Health • wpxi.com
Health board still paying for research with 'unclear' patient benefit

Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.

bbc.com logo
Oct 25 • 9:31 AM EDT • Health • bbc.com
Charles County Moves Forward With Employee Health Center

LA PLATA, Md. — Charles County commissioners took another step toward establishing a primary care center for county employees and their families Tuesday, Oct. 20, approving a contract with Marathon Health. The approval allows the county to move forward with planning and setting up the center. The proposed center would serve employees, retirees and family […]

thebaynet.com logo
Oct 24 • 6:00 AM EDT • Health • thebaynet.com
Goldman Sachs CEO David Solomon is optimistic about AI. Most of America disagrees.

“We’ll look back, 20 to 25 years from now, and the benefits will be really positive for our society,” the Wall Street leader said.

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Oct 23 • 6:31 PM EDT • Business • nbcnews.com
High-Signal Publisher
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit

As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...

yahoo.com logo
Oct 25 • 11:08 AM EDT • Politics • yahoo.com
Nvidia's RTX Spark has an NPU it barely mentions, and I spent a week figuring out what it actually is

Nvidia's RTX Spark packs an NPU that we know very little about, but I was able to get it working.

xda-developers.com logo
Oct 24 • 7:00 AM EDT • Technology • xda-developers.com
Google Health 5.11 rolling out with Fitbit Air Health Guardian, improved sleep tracking, & more

Google Health 5.11 is rolling out this week as a rather big update for Fitbit trackers and the Pixel Watch.

9to5google.com logo
Oct 23 • 5:00 PM EDT • Technology • 9to5google.com
Google gives Fitbit a major health upgrade with one catch

Some of its most advanced insights require a $9.99 subscription.

thestreet.com logo
Oct 24 • 3:33 PM EDT • Technology • thestreet.com
What should become a Detroit Lions tradition at Ford Field?

What fourth quarter tradition would best fit the Detroit Lions?

sports.yahoo.com logo
Oct 24 • 6:30 AM EDT • Sports • sports.yahoo.com
South Texas Health System (@stxhealthsystem)

2 likes, 1 comments - stxhealthsystem on October 25, 2026: "One Last Chance to Think Pink: Breast cancer remains the most common cancer among women after skin cancer, making routine screenings and early detection more important than ever. Mammograms can help identify breast cancer before symptoms appear, when treatment options may be most effective. Last week, South Texas Health System McAllen celebrated breast health and preventive care with a special Mammo Monday event featuring the vibrant sounds of mariachi music at the hospital’s main entrance. The celebration reflected STHS' ongoing commitment to encouraging women to prioritize their health through regular screenings. Now, there’s one final Mammo Monday remaining! Join us at STHS ER Mission on October 26 from 8 a.m. to 5 p.m. for the last breast cancer event of 2026. During the event, attendees can: 🎀 Learn about breast cancer screening options 🎀 Schedule a mammogram appointment 🎀 Receive a complimentary goodie bag while supplies last To help make preventive care more accessible, South Texas Health System is also offering reduced self-pay rates* throughout October: • 2D Mammogram: $100 • 3D Mammogram: $155 • Bone Density Screening: $160 A screening today could make all the difference tomorrow. Make your health a priority and encourage the women you love to do the same. For breast health resources and information on the Think Pink campaign, visit the link in our bio. *If not already a covered benefit of your insurance.".

instagram.com logo
Oct 25 • 7:41 AM EDT • Health • instagram.com
Bust companies revived in ‘phoenix’ deals more likely to fail again, study finds

Exclusive: Research for the Guardian says ‘pre-pack’ administration deals pay far less to creditors

theguardian.com logo
Oct 25 • 5:00 AM EDT • Business • theguardian.com
Interest rates unlikely to reach 4.75% by next summer, say City economists

Experts say Bank of England unlikely to increase rates by full percentage point – and could lower them by end of 2027

theguardian.com logo
Oct 25 • 8:00 AM EDT • Business • theguardian.com
Mass Effect Spiritual Successor Officially Reveals Redesigned Protagonist

Exodus reintroduces Jun following fan feedback

polygon.com logo
Oct 23 • 10:05 AM EDT • Technology • polygon.com
Business News: LVMH-Owned Zenith Is Restructuring In Major Reset As Brand Plans Job Cuts And Production Drop In Shift To High-End Market

Up to half of the employees at Le Locle manufacture could lose their jobs as the brand cuts models and production in restructuring after years of financial losses.

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Oct 23 • 12:27 PM EDT • Business • hodinkee.com
Google Health 5.11 rolling out expanded 100+ activity detection to Fitbit Air, Pixel Watch

Google Health previewed improved automatic activity tracking, and it’s now beginning to roll out with version 5.11 of the app.

9to5google.com logo
Oct 23 • 2:36 PM EDT • Health • 9to5google.com
From Wildwood to John Legend: your complete entertainment guide to the week ahead

Anination studio Laika takes flight with a grownup stop-motion tale, while the Grammy-, Oscar- and everything-winner returns with a Pharell-produced 11th album

theguardian.com logo
Oct 24 • 1:00 AM EDT • Entertainment • theguardian.com
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As devastating Xbox "reset" continues, Dishonored studio Arkane Lyon reportedly only has until November to find a new buyer before it's closed

Microsoft previously said it was reviewing "potential strategic options" regarding the much-loved developer.

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Oct 23 • 2:09 PM EDT • Technology • eurogamer.net
3 bonds are on the California ballot. Here's a last-minute voter guide to make sense of them

Californians will decide on $44 billion in bonds when the vote on Propositions 1, 37 and 38. They'd take out debt to pay for housing and medical research.

calmatters.org logo
Oct 24 • 9:00 AM EDT • Science • calmatters.org
With 52 Businesses Waiting, Charles County Weighs Expanding LaunchPad

LA PLATA, Md. — For dozens of Charles County entrepreneurs, getting a business off the ground includes another hurdle: waiting for a spot in a county training program. Economic development officials told the Charles County commissioners on Tuesday, Oct. 20, that 52 businesses remained on the waiting list for LaunchPad, a pilot program designed to […]

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Oct 25 • 6:00 AM EDT • Business • thebaynet.com
Thermo Fisher Scientific (TMO) Benefits on Broad-Based Recovery Across Life-Science Markets

Broyhill Asset Management, a Charlotte-based firm, issued its third-quarter 2026 investor letter. The letter can be downloaded here. The Broyhill Equity Composite decreased by 0.3% in Q3, underperforming the MSCI All Country World Index, which gained 1.7%. For the first nine months of the year, the Composite returned 1.9%, compared to 13.4% for the Index. The […]

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Oct 23 • 12:23 PM EDT • Science • finance.yahoo.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Cutting ‘red tape’ is nothing but a red herring

Blaming a moribund economy on too many rules is a hackneyed neoliberal trope – UK plc needs smarter regulation, not less regulation

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Oct 25 • 9:00 AM EDT • Business • theguardian.com
‘It’s magic’: scientists rediscover how to make ancient Roman colour-changing glass

Exclusive: Optical engineering that went into 1,600-year-old Lycurgus Cup has baffled experts for centuries

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Oct 25 • 2:00 AM EDT • Science • theguardian.com
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Aspen Science Center works to bring more science education to the region for all ages

Carbondale-based nonprofit the Aspen Science Center has expanded programming throughout local valleys, for residents of all ages, over the past 20 years. This story is part of our “On the Ground” radio series that highlights solutions to local and global issues from Roaring Fork and Colorado River valley organizations.

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Oct 23 • 7:56 PM EDT • Science • aspenpublicradio.org
Neko Health Turned a Dreaded Blood Test Into an Experience People Want to Repeat

Neko Health shows how a thoughtful, comfortable customer experience can turn a dreaded health screening into a service people want to repeat.

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Oct 24 • 1:00 PM EDT • Health • inc.com
Scientists reveal the hidden danger of missing blood pressure medication

Missing blood pressure medication could mean losing much of its protection against heart attacks and strokes, according to an analysis of more than 91,000 people. Patients who consistently took their medication experienced an 11% reduction in major cardiovascular events, while those who missed too many doses saw little or no measurable benefit.

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Oct 25 • 8:00 AM EDT • Science • sciencedaily.com
Ken and Angela Paxton invested $600,000 in a convicted fraudster’s business

The blind trust’s investment in Wildcatter offers a new, unreported look at the attorney general’s financial ties with the very type of business executives whose prosecutions he typically celebrates.

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Oct 23 • 12:00 PM EDT • Business • texastribune.org
Low-dose aspirin linked to 70% lower dementia risk, but there's a catch

A common, inexpensive medication could hold an unexpected clue to preventing dementia. Researchers found that older adults with a specific genetic profile had a 70% lower relative risk of dementia when taking low-dose aspirin, even though previous studies found no overall protective effect. The discovery suggests that genetics could help explain why some people benefit while others do not.

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Oct 24 • 8:00 PM EDT • Science • sciencedaily.com
AFP boss says politicians’ heated rhetoric is fuelling threats against MPs

Commissioner Krissy Barrett says women are more often singled out, often with threats of sexual violence

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Oct 24 • 11:54 PM EDT • Politics • theguardian.com
NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say

A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…

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Oct 25 • 10:20 AM EDT • Business • pilotonline.com
Small gyms increase health and connection in rural communities

Within the Adirondacks, outdoor recreation keeps people active. But small gyms popping up encourage indoor activity.

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Oct 25 • 6:30 AM EDT • Health • adirondackexplorer.org
'The church has ceded the commanding heights of science': New…

Huntsville could soon be home to a groundbreaking Christian liberal arts college focused on preparing students for careers in Science, Technology,…

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Oct 24 • 8:00 PM EDT • Science • 1819news.com
Kansas City leaders, non-profits and businesses turn unity into investments

Neighborhood leaders, nonprofits and businesses packed into Kansas City, Kansas, on Saturday, focused on turning unity into real investments.

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Oct 24 • 11:14 PM EDT • Business • kctv5.com
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Liverpool and Man United contacted about transfer of wonderkid

Liverpool have a fair few positions among their ranks that still need to be upgraded. The Anfield outfit have fallen behind their title rivals quite dramatically recently with most of their players fa...

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Oct 25 • 6:10 AM EDT • Sports • sports.yahoo.com
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Barack Obama rallies Michigan crowd for El-Sayed, saying he’s ‘fighting for real change’

Former president speaks to rapturous crowd of thousands in support of Democrat Abdul El-Sayed for US Senate

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Oct 24 • 7:50 PM EDT • Politics • theguardian.com
Dolly Parton, politics and pop culture inspire pumpkins at San Jose nonprofit event

The Silicon Valley Council of Nonprofits saluted community leaders at the 19th annual event Thursday.

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Oct 24 • 9:00 AM EDT • Politics • mercurynews.com
3 mental health habits that may help your blood pressure

Exercising and eating a healthy diet are important. But your mindset may benefit your health, too.

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Oct 25 • 5:00 AM EDT • Health • washingtonpost.com
Ramstad: Minnesota’s new leaders must face if high taxes harm growth

Minnesota has the nation’s second-highest business tax rate, following only New Jersey. But it will be No. 1 in 2029 if there’s no change.

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Oct 24 • 8:00 AM EDT • Business • startribune.com
You Don’t Need AI to Dumb Down Your Smart TV. Do This Instead

You could run vibe-coded, side-loaded projects on your TV to disable its more intrusive features, but you really don't have to. Here are several easier ways to minimize ads and stop tracking.

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Oct 24 • 9:00 AM EDT • Technology • pcmag.com
Two Shelby tax renewals on Nov. 3 ballot for health department and city parks department

Shelby's health and parks department requires tax revenue from Shelby residents to operate. Funding is on the Nov. 3 ballot.

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Oct 24 • 2:00 PM EDT • Health • richlandsource.com
Stop Chasing Views: How 87% of Creators Are Using AI to Build Real Businesses Beyond Social Media

87% of creators say AI is growing their business. Here's how creators trade social media algorithms for owned commerce and real enterprises.

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Oct 25 • 10:00 AM EDT • Business • inc.com
I've got egg on my face because Steam's Personal Calendar feature has apparently been a test this whole time and is only now actually a fully fledged component

Look, I've had a lot going on, alright?

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Oct 24 • 11:57 AM EDT • Technology • rockpapershotgun.com
I didn't believe this Claude wizardry could actually speed up my Google TV until I tried it

One prompt, less bloat, and barely any effort

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Oct 24 • 7:00 AM EDT • Technology • androidpolice.com