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A spatially programmable microfluidic chip for multi-stage particle and cell separation
A programmable microfluidic device developed at Institute of Science Tokyo, Japan, combines deterministic lateral displacement, a microfluidic technique that is used to separate particles according to their size, with temperature-responsive polymer micropillars to dynamically change the separation conditions along a single channel. Using this device, the researchers successfully separated multiple particle populations. Additionally, they efficiently isolated viable cancer cells, white blood cells, and red blood cells from diluted whole blood.