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The subtle ways a lack of vitamin D affects you
As winter approaches in the northern hemisphere and the days get darker, our bodies are suffering more than we realise. We need sunlight on our skin to produce the vital vitamin D, which is important for bone and muscle health and immune function, but there’s just not enough strength in the sun at this time of year to do it.
Too much RNA can starve cells of energy, scientists discover
Scientists have uncovered an unexpected danger lurking inside cells: too much RNA can damage the structures responsible for producing energy. A new study found that excess RNA, including the normally essential messenger RNA (mRNA), can directly disrupt mitochondria without relying on the immune system. The discovery could help explain how viral infections and certain aging-related diseases damage cells.
‘Healthy Rounds’: Supercharging the Immune System
Dr. Kapil Meleveedu, director of UConn Health’s Blood and Marrow Transplant and Cellular Therapy Program, joins Dr. Anthony Alessi’s podcast
Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)
Lead with gut health substantiation, not speculation at SupplySide Global
From digestive comfort to immune health and mental wellbeing, discover how Bimuno GOS supports targeted product innovation. Visit booth 4249 at SupplySide Global to explore the science
Researchers have uncovered a likely origin of our allergies
While bacteria and viruses set off immediate alarm in our immune system, allergies follow a different path.
Researchers have uncovered a likely origin of our allergies
While bacteria and viruses set off immediate alarm in our immune system, allergies follow a different path.
Scientists turn cancer-promoting protein into a weapon against tumors
Researchers have discovered that a protein known to help cancer cells thrive can also make immune cells more effective at destroying tumors.
Women with autoimmune diseases are more likely to be misdiagnosed with mental health conditions
More than 40% of women with autoimmune diseases are told they have psychiatric conditions, new research shows. That is only true of 33% of men.
USC scientists discover how to create a never-ending supply of cancer-fighting cells
USC scientists have discovered a way to create a potentially renewable supply of genetically engineered immune cells that can attack cancer and strengthen the body's natural defenses. By growing and modifying immature immune cells rather than mature ones, researchers developed a system that can continuously produce tumor-fighting cells inside the body.
Gut health may affect more than digestion, doctor says
A diverse gut microbiome can influence digestion, immune function and the body’s communication with the brain, pathologist Dr. Ryan Cole said in an interview with The National News Desk.
8 Ways to Boost Your Oral Health With Sjögren’s Disease
This autoimmune condition reduces saliva production, leaving teeth and gums vulnerable to decay. Stay on top of your oral health with these expert tips.
Fighting off microbial invasions drains plants' iron stores, but one protein helps restore balance
Energy production in our cells, oxygen traveling in our blood and immune cells fighting infection all depend on iron, an essential mineral that enters the food chain when plants absorb it from soil. But ...
Surveillance, tick testing help combat rise of Alpha-Gal syndrome
A tick-borne medical condition that rewires the human immune system is becoming an increasing focus of force health protection for the Department of War
Broward Health Medical Center Introduces Bispecific T-Cell Engager Therapy for Cancer Patients - Florida Hospital News and Healthcare Report
OCTOBER 13, 2026 – Broward Health Medical Center has introduced bispecific T-cell engager (BiTE) therapy, an innovative immunotherapy that harnesses the body’s immune system to target and destroy cancer cells. […]
Joe Manganiello says Armie Hammer-recommended second shaman told him he wasn’t meant to marry Sofía Vergara
Joe Manganiello said a shaman suggested his marriage to Sofía Vergara was a ‘booby trap’ that led to his mysterious autoimmune disease.
Scientists discover how harmful “zombie cells” hide from the immune system
Scientists have discovered a protein that may help harmful aging cells hide from the immune system, allowing them to accumulate and fuel age-related health problems. Blocking the protein in mice reduced these cells and inflammation while improving blood sugar regulation and strength, offering a promising new direction for anti-aging research.
BROWARD HEALTH MEDICAL CENTER INTRODUCES BISPECIFIC T-CELL ENGAGER THERAPY FOR CANCER PATIENTS - Florida Hospital News and Healthcare Report
October 13, 2026 – Broward Health Medical Center has introduced bispecific T-cell engager (BiTE) therapy, an innovative immunotherapy that harnesses the body’s immune system to target and destroy cancer cells. […]
Scientists identify clues to making immunotherapy more effective against glioblastoma
Two new studies led by researchers at the UCLA Health Jonsson Comprehensive Cancer Center provide new insight into how the immune system can successfully be activated against glioblastoma while revealing ...
Eye Microbiome: How Bacteria May Influence Eye Health and Disease
The ocular surface hosts a low-abundance microbial community that may help regulate immune defenses, while changes in its composition have been associated with inflammatory and infectious eye diseases. Research into the gut-eye axis and microbiome-targeted therapies suggests possible diagnostic and treatment applications, but the underlying mechanisms, causal relationships, and clinical effectiveness remain uncertain.
Women ‘more likely to be told autoimmune conditions are psychological’
Cambridge University study suggests stark gender divide in misdiagnosis, with women also waiting longer for treatment
Immune Cell Map Uncovers How Individual Aging Trajectories Diverge
Researchers created an immune aging map showing that a balance between two immune cell types can predict future health. The findings link immune aging patterns to risks of chronic disease, mortality, and unhealthy aging.
Blood proteins may offer new clues to gut health in celiac disease
Celiac disease is an autoimmune condition in which the immune system reacts adversely to gluten. Eating gluten causes inflammation in the gut, which can damage the intestine and impair its ability to ...
Blood proteins may offer new clues to gut health in coeliac disease
Coeliac disease is an autoimmune condition in which the immune system reacts adversely to gluten. Eating gluten causes inflammation in the gut, which can damage the intestine and impair its ability to absorb nutrients.
Scientists have identified a 'protein signature' in blood that could predict healthy aging
Having a certain ratio of proteins produced by immune cells in your blood is linked to a higher risk of age-related diseases, scientists report.
Blood Proteins May Offer New Clues to Gut Health in Coeliac Disease
Coeliac disease is an autoimmune condition in which the immune system reacts adversely to gluten. Eating gluten causes inflammation in the gut, which can damage the intestine and impair its ability to absorb nutrients.
Zuckerberg's image is in trouble - but Meta's business is booming
A new film paints the Meta founder as a villain. But the tech firm seems immune to bad publicity, writes our North America tech correspondent.
Northwest Biotherapeutics and the UK National Health Service Blood and Transplant Announce Collaboration to Support DCVax®-L Production
/PRNewswire/ -- Northwest Biotherapeutics (OTCQB:NWBO) (the "Company" or "NWBio"), a biotechnology company developing DCVax® personalized immune therapies for...
Scientists warn a popular vitamin D supplement may have a hidden downside
Not all vitamin D supplements are created equal, and new research suggests that one popular form may have an unexpected downside. Scientists found that taking vitamin D2 can actually lower the body's levels of vitamin D3, the form naturally produced by sunlight and more effective at boosting overall vitamin D. Previous studies also suggest that vitamin D3 may provide stronger immune protection against viruses and bacteria.
Joe Manganiello says local shaman healed him from deadly condition
In a new book, 'Bloodlines,' which drops Oct. 13, Joe Manganiello details a debilitating autoimmune disease that, he says, destroyed his marriage with Sofía Vergara and forced him to undergo 'major organ amputation.'
Evening of Purpose helps fight complex disease
ROCKY MOUNTAIN MS CENTER Aurora News: The simplest way to describe Multiple Sclerosis is that it is a complex, unpredictable disease for which there is no cure. On a deeper dive, medical professionals will say it’s a cruel disease, one where the immune system attacks the central nervous system, affecting the brain, spinal cord and optic […]
Joe Manganiello opens up about near-fatal autoimmune disease battle
Joe Manganiello opened up about his health struggles, including a harrowing battle with autoimmune disease, in a new interview with People magazine.
Northwest Biotherapeutics Announces Keynote Presentation on Harnessing Immunity: A Personalized, Multi-Target Approach to Cancer At the UK National Health Service Annual Oncology Conference
/PRNewswire/ -- Northwest Biotherapeutics (OTCQB:NWBO) (the "Company" or "NWBio"), a biotechnology company developing DCVax® personalized immune therapies for...
The Nobel Prize Week Is Kicking off in Stockholm With the Medicine Award
STOCKHOLM (AP) — This year's Nobel Prizes will kick off on Monday with the awarding of the medicine prize at the Karolinska Institute in Stockholm. Last year, three scientists won the Nobel Prize in medicine for discoveries about how the immune system knows to attack germs and not our own bodies.
At San Francisco General, researchers are learning how to control HIV without drugs
Doctors at San Francisco General Hospital's famed AIDS clinic have shown the immune system can be primed to keep the virus in check — a promising advance just as U.S. funding cuts threaten future research.
Research uncovers how bacteria fight viruses, opening the door to better virus-based antibiotics
Bacteriophages are viruses that can attack harmful bacteria, whose "last resort" immune response kills the infected bacterium before the virus can spread to others.
Regular exercise reshapes the immune system at a cellular level, study suggests
Regular exercise makes our immune cells more vigilant, potentially contributing to better long-term health, a new study finds.
Scientist whose work revealed immune system-hypertension link to receive the 2026 Joseph A. Vita Award
Embargoed until 8 a.m. CT/9 a.m. ET, Wednesday, Sept. 30, 2026 DALLAS, Sept. 30, 2026 — A groundbreaking scientist whose discoveries revealed how immune activation and inflammation contribute to high blood pressure will be recognized by the American...
ASK DR. DAVE: Naturopathic doctor shares more tips to boost immune health
ASK DR. DAVE: Dr. Dave Hamilton explains how herbs may support immunity.
Scientists supercharge plant immunity to boost its natural defense response
Nanyang Technological University, Singapore (NTU Singapore) scientists have developed a way to "supercharge" a plant's natural immune response.
Crew Studies Advanced Health Tech and Gears Up for Next Crew Swap
Ultrasound scans using augmented reality and artificial intelligence topped the health research schedule aboard the International Space Station on Wednesday. The Expedition 75 crew also collected blood and saliva samples to study how the immune system adapts to weightlessness. The orbital residents are now preparing for a crew swap as NASA’s SpaceX Crew-13 mission announces a launch date.
Is 50 the new 60?
Subscribe TL;DR: Younger generations are showing signs of worse health compared to earlier-born cohorts at the same age This backward “drift” is showing up both in mortality risk and chronic disease Worsening trends in obesity and diabetes are the most consistent signals Taking the long view, we’ve made astonishing gains in health and life expectancy in the last century. Global average life expectancy has more than doubled from 32 years in 1900 to 73 years in 2024. (But don’t forget, there were still old people when life expectancy was 32). As people lived longer, they also generally lived healthier along the way. It turns out that avoiding things that can kill you early, like malnutrition and lots of childhood infections, also keeps you healthier later in life. In a classic 2004 paper, Finch and Crimmins proposed that cohorts of children who benefited from fewer early life infections had less lifetime exposure to inflammation and cardiovascular disease later in life, accelerating mortality improvements at older ages. Poor nutrition in the womb has also been linked to a higher risk of later chronic disease. The upshot is that improvements in childhood health can pay dividends many decades later. The combination of better living conditions (nutrition, sanitation) and medical advances (antibiotics, vaccines, blood pressure meds, etc) meant that people’s healthy lifespan generally expanded, even as they lived longer. Aging researchers call this best-case scenario “compression of morbidity”—meaning we delay the onset of disease and disability even faster than the years of life we are adding. During my 20+ year research career, we could generally bank on the idea that younger generations would not only live longer but also keep getting healthier along the way. “60 is the new 50” as they say… Enter “Generational Health Drift” Sadly, this expectation of steady progress may be changing. You’ve probably heard that US life expectancy gains have slowed to a crawl in the past couple of decades. Mortality improvements are also slowing (though less dramatically) in many other high-income countries (you can read more about that in a review paper I wrote here). Mortality is a very blunt health measure, but it is often a good barometer for the broader population health trends happening underneath. And we are now seeing that younger generations may be in worse health at similar ages compared to earlier born cohorts. My collaborator Prof. George Ploubidis at University College London coined this worsening health in more recently born cohorts “generational health drift.” “Generational health drift” is bad news on multiple fronts. Most obviously, we don’t want our health progress to go backward. But the timing is also bad, since our populations are aging. In demographic terms, “population aging” means that the proportion of the population at older ages (i.e >65 years) is increasing. Fun demography fact: Current population aging is not due to the recent declines in the birth rates making the news, but declines in fertility decades ago, after the “baby boom.” As baby boomers reach older ages, the smaller cohorts behind them mean the percentage of older adults will increase. For example, the share of the population age 65 and older in the US increased from 12.4% in 2004 to 18.0% in 2024. This story of population aging was written long ago. Many worry that population aging will put pressure on health care and pension systems. But if people reach older ages in better health than in years past, those fiscal pressures would be less dire than projected. Healthy older people can also continue to contribute to society in many valuable ways, including paid work, caregiving, community service….even high political office 🤷. On the flip side, if younger generations reach retirement age in worse health and with more disabling conditions, this could magnify the societal challenge of population aging. Evidence for worsening generational health A recent paper that I LOVED in the Proceedings of the National Academy of Sciences by Dr. Leah Abrams and colleagues examined which birth cohorts (aka generations) were behind worsening US mortality. Behold the Lexis diagram (cue swooning demographers). Calendar time is on the x-axis, age on the y-axis. Birth cohorts can be followed over time as they age on the diagonal lines moving up and to the right. This figure plots the year-on-year % change in all-cause mortality at a given age. Green shading indicates mortality improvements over time, white is stagnation, and gray shading indicates worsening mortality. Following the diagonal line for those born in 1950, you can see a noticeable shift from green to gray that follows this cohort for most of their lives. This gray shading shows generally worsening mortality for the 1950 to 1959 birth cohorts compared to their predecessors across all ages. Concerningly for my GenX and elder millennial peeps, there was also a deterioration in mortality for birth cohorts born in the 1970s and 1980s, visible as dark gray areas at ages 30 to 45 during the 2010s. While some of these mortality changes reflect specific shocks such as the opioid epidemic, most deaths still occur from major causes of death such as cardiovascular disease and cancer. For cancer, the gray in the top left corner of the figure below reflects the legacies of smoking for older cohorts, followed by a period of green with improvements in cancer mortality as smoking rates declined. But the white/gray shading in the bottom right corner highlights a stagnation and reversal of the cancer trends, with cohorts born around 1970 to 1985 experiencing worsening cancer mortality. This deterioration was most noticeable for colon cancer mortality, possibly linked to obesity or dietary factors. Not just dying more, but less healthy along the way. A recent paper by Dr. Laura Gimeno of University College London (of which I am a co-author), found evidence that more recently born cohorts in Great Britain have stagnating or worsening health. A stylized picture of what“generational health drift” might look like: The review paper found: Rates of childhood overweight and obesity were highest among Gen Z. Rates of diabetes in the 40s almost doubled from 3.1% among the Baby Boomers to 5.9% in Generation X. Gen Z reported higher rates of poor mental health in adolescence compared to earlier-born groups. These UK results are consistent with studies showing worsening health across generations in the US as well. A 2021 US study found that more recently born cohorts had worse biological markers (like blood pressure and blood sugar) than earlier generations at the same age. A separate 2022 study of Americans aged 50 and over found that more recently born generations had a higher number of chronic diseases, with younger age of disease onset. A 2024 Lancet paper found that in the US, women born in 1945 had 33% obesity prevalence at age 50, rising to 48.2% for women born in 1970 turning 50. So what’s going on, and can we turn it around? We don’t have a definitive answer for what’s causing the deteriorating health of younger cohorts, but circumstantial evidence points to worsening trends in obesity and diabetes in both the US and UK. Remember that cohort trends reflect lagged effects of early environments, and younger generations have faced both earlier onset and more severe obesity across their lifetimes. Despite these very concerning trends, the future is not set in stone. We’ve reversed poor generational health trends before: drops in smoking are a major reason cancer and heart disease deaths fell so dramatically in recent decades. GLP-1 drugs may finally turn the tide against rising rates of obesity and diabetes, though it is still early days. But things could also get worse…for example from a return to higher levels of childhood infectious diseases that can have a lasting impact on health. See for example: [ ](https://jenndowd.substack.com/p/dont-you-forget-about-measles-the) [ Don’t You Forget About Me(asles): The Virus That Erases Immune Memory ](https://jenndowd.substack.com/p/dont-you-forget-about-measles-the) Jenn Dowd, PhD · March 24, 2025 [ Read full story ](https://jenndowd.substack.com/p/dont-you-forget-about-measles-the) Even as an optimist, emerging data on the “generational health drift” has my full attention. For most of my research career, we took it for granted that each generation would be healthier than the last. But if present trends continue, **50 could be the new 60….**and Gen Z celebrities will soon look older than Paul Rudd :). Stay well, Jenn Share the Health! If you found this post useful, please share it with a friend. Share
Sepsis: Spot the signs, save a life
This post was written by Jennifer Rechter, MSN, RN-BC, AG-CNS, sepsis coordinator.Battling an infection is tough work for the body’s immune system, and...
Scientists Have Uncovered Previously Hidden Microbial Activity on Human Skin
The most abundant microbes on your skin may not be the ones doing most of the work. Human skin supports vast communities of bacteria, fungi, and viruses that can influence its protective barrier, immune defenses, and overall health. Yet simply cataloging these organisms cannot reveal which ones are active, how they respond to their surroundings,
When DNA sounds a lasting alarm: cGAS-STING links aging to brain inflammation
Neurodegenerative diseases, cerebrovascular disorders and other age-related neurological conditions are major causes of long-term disability. A review published in SCIENCE CHINA Life Sciences by researchers from Huashan Hospital, Fudan University, examines how damaged nuclear DNA and mitochondrial DNA can become immune danger signals. The authors highlight cGAS-STING as a key molecular hub linking cellular damage, inflammaging and neuroimmune dysfunction, and discuss opportunities for more precise therapeutic intervention.
Ayble Health banks $16M series A to expand AI-driven precision digestive, autoimmune healthcare
Ayble Health secured a $16 million oversubscribed series A funding round to accelerate its expansion into artificial intelligence-driven precision digestive and autoimmune healthcare. | Ayble Health says it is currently in-network with most commercial health plans, covering more than 80 million patients through its various partnerships.
Scientists find an immune “false alarm” that may drive rapid aging
Scientists have discovered that some severe genetic disorders linked to rapid aging may be driven not just by damaged DNA, but by the body’s overreaction to that damage. When broken DNA fragments leak into the wrong part of a cell, an immune sensor called cGAS can mistake them for signs of a viral infection, triggering chronic inflammation and even interfering with DNA repair itself.
Whoever Put Together The Kingdom Hearts Fortnite Trailer Knows Ball
I am not immune to propaganda, especially if it comes wrapped in Hikaru Utada's 'Sanctuary'
Scientists discover a major brain shift between ages 50 and 75
Scientists have uncovered sweeping changes in how the human brain controls and organizes its genome beginning in midlife, offering new clues to why aging sharply increases the risk of Alzheimer’s and other neurodegenerative diseases. One of the biggest shifts occurred between about ages 50 and 75, when many of the brain’s original immune cells declined and were replaced by cells with more inflammatory characteristics. Researchers also found weakening of cells that help maintain the blood-brain barrier, along with widespread deterioration in the genome’s three-dimensional organization.
Drugs for autoimmune diseases are pricey. This bill could switch patients to a cheaper one
Nearly 25,000 Californians could get switched to a cheaper drug next year — unless their doctor objects.
Blue light boosts key medicinal compounds in Astragalus, study finds: Multi-omics and genetic tools uncover light-driven isoflavonoid biosynthesis
Astragalus mongholicus, a cornerstone of traditional Chinese medicine, produces isoflavonoids—bioactive compounds with anti-inflammatory, immune-boosting, and antiviral properties.
Opinion: What Chicago needs to understand about its climate resilience
No place on Planet Earth is immune from the impacts of a warming planet. And in an interconnected global economy, there is no “climate haven.”
DKMS backs $1.08m push on transplant science
New $1.08m grant aimed at the immune biology behind stem cell transplants, a research problem getting more urgent as more people live longer.
Science researchers honoured by RSC
New fellows are leading experts on sustainable agriculture, fish adaption and plant immune response.
Scientists engineer ready-to-use cancer-fighting T cells for solid tumors
T-cell receptor, or TCR, therapy is a cancer treatment that genetically reprograms immune cells, called T cells, to hunt down cancer with precision. It's similar to another treatment, CAR T-cell therapy, ...
Immune Cells’ Role as Quality Control Boosts Tissue Health
Macrophages maintain the function of certain organs by eliminating waste products. Studying this process could lead to clues for healthier aging.
Why getting your hands dirty is good for you
Putting our hands in soil and touching grass, trees or moss provides a wide range of health benefits, for our skin and wider immune system.
Why getting your hands dirty is good for you
Putting our hands in soil and touching grass, trees or moss provides a wide range of health benefits, for our skin and wider immune system.
Researchers identify new therapeutic target for salt-sensitive hypertension
The researchers discovered that a signaling pathway called AP-1 complex links dietary sodium to immune-driven salt-sensitive hypertension.
Blocking One Immune Signal Reversed Signs of Aging in Mice
"We've been trying to figure out why."
The science behind the beauty business
Some of Europe’s industrial champions may be in retreat, but its cosmetics sector remains a global leader, buoyed by healthy demand, recognised brands and a reputation for innovation."The fact is, the science in cosmetics is better here in Europe than anywhere else in the world,” says Pierre Morvan, CEO of Technature, a private label cosmetics manufacturer located near Brest in France’s northwestern Brittany region. “You have to have good science in order to make the difference, and that is why we invest so much in research and innovation.”Across Europe, the beauty and skincare products sector supports an estimated 3.6 million jobs, including 265,000 employed directly in the industry, according to the Cosmetics Europe trade group.. Cosmetics production contributes an estimated €11 billion to the EU economy, and generated €30 billion in export revenue last year, a €400 million rise from 2024.Technature itself has a global footprint, supplying products for 1,500 brands in 65 countries. Its range of skin gels, facial masks, nail treatments and other products include natural ingredients and extracts derived from plants, such as seaweed, that are developed and refined through science-based analysis and testing.While industry projections point to sustained growth for the foreseeable future, driven by emerging economies and wider availability of exclusive brands that were once chiefly sold by high street retailers, the sector is not immune to the impact of geopolitics and trade wars. The Trump Administration’s tariff threats have dented cosmetics exports to the EU industry's largest overseas market. After the European Parliament approved the EU-US Turnberry Agreement in June, setting a 15% levy on many EU goods, the French Federation of Beauty Companies warned that “exports are falling sharply” and urged the EU to negotiate an opt-out for cosmetics.Technature’s CEO flags South Korea as an emerging competitor, partly due to its assertive marketing efforts. “I would have to say I am a little bit scared,” Morvan says, regarding the growth potential of the South Korean cosmetics industry. “This is why science and innovation are so important if Europe is to remain the leader.”With a workforce of 200, including biologists, chemists and other scientists, around 15% of Technature’s staff work in three research and development (R&D) labs. A similar number work in four quality control and assurance facilities, where science plays a crucial in ensuring product safety in a sector that is subject to the European Cosmetics Regulation.Educational exchange between industry and academiaIn recognition of Technature’s research and innovation, Morvan was selected as one of Brest’s ambassadors to Science Comes to Town (SCTT), a European initiative to strengthen communications and understanding between science and society. Brest is one of three coastal cities in the EU-funded programme, alongside Split (in Croatia) and Kiel (in Germany). From 7-11 September, Brest will host the EU TalentOn contest featuring 100 early-career researchers from across Europe.Morvan appreciates the value of engagement with educational and scientific institutions as well as the home community. For instance, Technature collaborates closely with university partners to enhance its in-house R&D. In addition, it invites students to its labs and sends its own researchers to local institutions. "We absolutely want the students to know what the industry is all about,” Morvan says, noting that seeing science in action can help young people “understand that they can do something real with science, to create something with what they are learning.” He says another important benefit: encouraging new generations of young people to consider a career in cosmetics.Community involvement also raises awareness about Technature and the skincare industry as a whole. “The public gains recognition of the innovative company that we are, and this is important for getting new customers,” Morvan says. One of its recent innovations — tiny, colourful cosmetic pearls that release skin moisturisers on application — was showcased at this year’s VivaTech event in Paris.Morvan holds a master's degree from the Brest Business School and studied animal production and biology in Brest at the University of Western Brittany (UBO), an SCTT partner, and at the University of Tours. He got his start in business in 2002, initially working on using seaweed as a raw material in the food industry before transitioning to cosmetics. Morvan has always been interested in connecting science and business, reflecting one the goals of SCTT to enhance public-private collaboration.The invitation to participate in SCTT was unexpected. “It was a surprise to get a call from the city of Brest saying that they wanted me on this programme,” Morvan recalls, adding that officials were drawn by his company’s R&D. “It's not only theory and science fundamentals. Our science is something that is applicable to the global market — and important for the community.”Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.
Scientists find breast cancer cells hiding behind protective “shields”
Researchers have mapped breast tumors in striking detail and uncovered hidden pockets of dormant cancer cells that may help explain why cancer can return after treatment. Unlike rapidly dividing cells, these quiet cells can essentially hibernate, allowing them to evade chemotherapy and reactivate later. The team found that they are often surrounded by immune cells and connective tissue cells that may act like a protective shield.
Studying the holistic health habits of tropical bats
What do bats do when they feel ill? SELFCURE, a multi-disciplinary project taking place in Gamboa, Panama, tracks the behavior of tropical bats when immune-challenged to understand how they take care of themselves, and what lessons we can learn from them.
Judi Health Taps Color Health, WellTheory, Cylinder for Clinical Ecosystem
Judi Health expanded its healthcare network to offer specialized virtual care for cancer, autoimmune and GI conditions while helping employers reduce overall healthcare costs.
Study Identifies Potential Therapeutic Target Protein that Drives Metabolic Liver Disease Independent of Diet
The protein appears to cause liver damage by triggering an out-of-place antiviral immune response. Blocking this pathway can protect against liver injury in human cells and mouse models, even on a high-fat diet—paving the way for therapies to prevent liver damage.
Scientists may have found a shortcut to calorie restriction’s anti-aging benefits
Moderate calorie restriction lowered an immune protein called C3 that appears to help drive chronic inflammation as the body ages. Blocking the same protein reduced age related inflammation in mice, raising the possibility that future treatments could mimic some benefits of calorie restriction without severe dieting.
When it comes to women’s health, money talks
Women's health experts suggest a 'reverse pitch' approach to endometriosis, osteoporosis, and autoimmune treatments, stressing the profit potential.
A Defunct Nuclear Site Had a Meltdown in 1959. A New Study Shows It's Still Causing Health Problems
Researchers found elevated reports of autoimmune and endocrine disorders among people living within 5 miles (8 kilometers) of the Santa Susana field Laboratory.
Dolly Parton’s 9 to 5 was uniting the country
At a time when no American celebrity seems immune from the country’s many divisions, Dolly Parton was a crossover icon who stayed neutral in the culture wars while still speaking her mind.
Supercharged “natural killer” cells could be a powerful new cancer weapon
Researchers have found a way to supercharge natural killer cells, powerful immune cells that can attack cancer, so they can penetrate solid tumors and keep fighting once inside. In mice, these specially prepared tissue-resident cells slowed the growth of several tumors, including melanoma and head and neck cancers, and worked even better when paired with the antibody drug cetuximab.
Major brain changes that occur around age 50 could impact dementia risk
Microglia decline after age 50 as inflammatory blood-derived immune cells infiltrate the hippocampus, potentially driving neuroinflammation and dementia.
Scientists discover new 'immune hubs' in skull bone marrow
In mouse skull marrow, 'immune hubs' that actively defend the brain have been discovered. Similar cells exist in human skulls, but their role remains unclear.
This yeast supplement may boost cancer-fighting immunity
A simple yeast-based food supplement may help restore the immune system’s ability to fight cancer, according to new research in mice. Scientists found that yeast beta-glucan reprogrammed early immune cells in the bone marrow, leading to stronger, longer-lasting cancer-fighting responses against colorectal, skin, and breast cancer cells.
AI may know how you’ll respond to a vaccine before you get it
AI may be able to predict how strongly someone will respond to a vaccine before they receive it. By analyzing antibody patterns in more than 4,000 people, researchers found signs of “immune readiness” that helped distinguish strong responders from weak ones. Surprisingly, even some healthy people responded poorly, while some immunosuppressed people mounted strong responses.
This weight-loss hormone may protect the liver even without weight loss
A hormone already known for curbing appetite and supporting weight loss may have a surprising second job: protecting the liver from inflammation and scarring. Researchers at McMaster University found that GDF15 activates a previously unknown brain-to-liver pathway that triggers the release of glucocorticoids, helping calm immune activity in the liver.
Maternal Systemic Autoimmune Rheumatic Diseases Tied to Higher Risk for Mental Disorders in Kids
Children born to mothers with systemic autoimmune rheumatic diseases have higher risks for a range of mental health conditions, particularly anxiety disorders, a study finds.
Newly-discovered immune hubs in our skull may keep our brain healthy
We may have clusters of immune cells at the back of our skull that help ward off conditions like brain cancer
Scientists turn probiotic bacteria into tiny drug factories for pancreatic cancer
Engineered probiotic bacteria were able to infiltrate pancreatic tumors, stimulate cancer-fighting immune cells, and slow tumor growth in animal studies. Even more strikingly, the treatment worked better when combined with chemotherapy, radiation, or immunotherapy.
Researcher-artist paves the way for science communication
Lulu Perez ‘26 is a behavioral neurosciences alumna. She is a researcher in an FIU lab that investigates how complex sugars can regulate immune and cancer cell function and slow cancer progression. She is also an artist. Perez attended an arts-focused school, where she learned to paint in traditional mediums like acrylic, oil and watercolors,
I quit my job while pregnant and battling an autoimmune disease
Alex Taylor used to work long hours. Then she quit her job, changed her lifestyle, and founded a healthcare brand.
I quit my job while pregnant and battling an autoimmune disease
Alex Taylor used to work long hours. Then she quit her job, changed her lifestyle, and founded a healthcare brand.
Youth-associated protein helps restore healthy function in immune cells in the aging brain
Researchers at the Icahn School of Medicine at Mount Sinai have identified a role for the youth-associated protein TIMP2 in supporting the healthy function of microglia, the brain's resident immune cells.
Immune cells flood into the aging brain, Stanford scientists discover
Scientists have discovered that the aging human brain may be far less isolated from the rest of the body than once believed. Stanford researchers found that large numbers of immune cells from the blood begin entering the brain as early as middle age, where they can transform into microglia, the brain’s specialized immune cells. The finding overturns a long-standing assumption that these cells remain largely separate from the body’s immune system throughout life.
Sanofi suspends chronic lung disease phase 2 study, tied to ‘strategic business reasons’
Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce Biotech has learned. The trial, which began only back in April, was a randomized, double-blind, placebo-controlled study to measure the reduction in mucus plug score following treatment with SAR445399 compared with placebo in adults aged 18 to 80 years with NCFB, a chronic lung disease. The trial was officially reported as halted on July 29, the day before Sanofi’s second-quarter earnings call. The decision to pause the trial was made “as part of a company-wide portfolio review for strategic business reasons,” and not due to safety concerns, a Sanofi spokesperson told Fierce. The move to pause the NCFB trial comes during a trying time for Sanofi following a year filled with a series of trial fails. In February, the French pharma ousted CEO Paul Hudson and appointed Merck KGaA leader Belén Garijo, M.D., Ph.D., to steer the ship. Since then, Garijo has been doing a deep dive on correcting the company’s strewn R&D and clinical strategies. On July 24, Sanofi scrapped amlitelimab for atopic dermatitis, despite its lore as being a potential $5 billion blockbuster. During its second-quarter report, the company abandoned two more assets, balinatunfib and itepekimab, following failed trial results in psoriasis and chronic obstructive pulmonary disease, respectively. SAR445399, only first revealed by Sanofi in 2023, is an anti-interleukin-1 receptor 3 monoclonal antibody developed to block the interleukin 1, 33, and 36 cytokine pathways. These pathways can be important in chronic immune-related dermatologic diseases, such as atopic dermatitis and hidradenitis suppurativa, as well as respiratory conditions, such as NCFB. Related Sanofi’s new CEO ‘looking deeply’ at late-stage pipeline as clinical clearout continues NCFB affects roughly half a million people in the U.S., with a global incidence of greater than one million cases. In August 2025, Insmed received FDA approval for Brinsupri, a DPP1 inhibitor targeting neutrophil activation, for treatment of NCFB in adults and kids ages 12 and older. The British biotech Infex Therapeutics showed promising NCFB phase 2a data using their monoclonal antibody, INFEX702, which acts by disabling Pseudomonas aeruginosa, a bacteria known to be a major pathogen of NCFB. Sanofi is currently running a separate phase 2 study testing SAR445399 as a potential treatment for the inflammatory skin condition hidradenitis suppurativa.
Stanford scientists discover immune cells that explode like microscopic bombs
Stanford researchers discovered immune cells in flatworms that explode within minutes, killing nearby bacteria and foreign cells before vanishing completely. Their unusually fast and localized attack could offer clues for developing targeted treatments against infections and cancer.
The Beauty Of Settled Science
Commenters convinced me I made a subtle mis-step in my framing of Psychology Research Is Mostly Fine. My framing emphasized that social priming studies had failed to replicate, but that many other subfields of psychology hadn’t. This naturally led commenters to point to failed replications in other subfields. Although none of these were as bad as social priming, few or none were entirely problem-free. Instead of emphasizing the difference between social priming and other subfields, I should have emphasized the difference between settled science and novel research. Here are some of my favorite psychology findings: The brain is sculpted by reinforcement learning, and a key driver of this learning is a prediction-error-based algorithm located in the nucleus accumbens and implemented through dopamine. Psychedelic drugs exert their effects through 5-HT2A receptors, pointing to a role for these receptors in some sort of construct like the balance between priors and new evidence. Certain cognitive functions are localized to certain brain areas (for example, impulse control to the frontal lobes; linguistic structure to Broca’s area, linguistic meaning to Wernicke’s area. But injure one of these areas, or render a certain function useless (eg a blind person having no more use for their visual cortex), and these mappings can gradually shift - suggesting that neurons are general-purpose compute whose specialization is a contingent fact about convenience and efficiency rather than a necessity. Most personality traits and general capabilities are about 50% genetic and 50% random, with little role for family environment or childhood history, with a few notable exceptions like partisan preference. Recent research complicates this story, but the further you go from this basic picture, the gnarlier the chains of indirect causation you require. Neurons fire together in “brain waves”, whose exact frequency corresponds with the character of consciousness; These divide neurons into natural subpopulations and linked graphs. The gamma rhythm corresponds surprisingly well to items in conscious awareness. GABA receptors seem to be involved in something like relaxation. By hitting different GABA receptors in different ways, you can modulate the exact type of relaxation you produce. Hitting GABA-A directly is too powerful and can cause dangerous levels of sedation, but allosteric modulation of GABA is an incredibly fruitful strategy that underlies drugs from benzos to barbituates to alcohol. If you know your GABA-A subunits, you can target specific subtypes of relaxation; for example, Ambien hits GABA-A1 and induces sleep. Memory divides somewhat fuzzily into bins of immediate-sensory, short-term, and long-term, with separate retrieval and storage functions, and separate systems for declarative vs. procedural learning. These can be harmed selectively, usually by hippocampal injury, so that some patients can remember their life stories but not form new long-term memories, or learn new skills like bike-riding but not new facts. The exact substrate of memory is unclear but seems to involve new synaptic connections between neurons in at least some way. The ability of modern psychology and psychiatry to treat mental illness is real but limited. SSRIs work for half or slightly fewer than half of patients; antipsychotics work with extreme side effects; benzodiazpines work but produce addiction and tolerance in many (not all) people. Most supplements are stuck in Poor Quality Study Replication Crisis Hell, but melatonin and l-theanine stand out as especially promising. Psychotherapy works with moderate effect size, but (with a few exceptions) seems to be more about the relationship with the provider than the details of the therapy itself. Mental hospitalization can sometimes defuse immediate crises but work less well than mental hospitals would like, with some studies showing overall negative effects. Schizophrenia is mostly genetic, but risk also increases with prenatal infection (especially rubella) and obstetric complications; there is suggestive evidence for roles of social stress and drug use (with psychedelics and marijuana making things worse, and nicotine if anything making things better). Bipolar and schizophrenia are so closely linked on a pathophysiological level that it seems like they might be the same disease; on the clinical level, they do seem to follow two separate courses/prognoses but can sometimes surprise clinicians by eg someone who seemed condemned to permanent schizophrenia unexpectedly recovering. The brain’s native reinforcement learning algorithms cash out in the phenomena of classical and operant conditioning; different reinforcement schedules reinforce at different levels, which can be exploited by bad actors to make especially compelling products (eg slot machines). None of these are immune to doubt. A few are speculative; one or two are genuinely unorthodox. But they’re all a step above one p = 0.049 paper that might not replicate. If they get overturned, they’ll be overturned by the same sort of genuine scientific shift that replaced Ptolemy with Copernicus or Lamarck with Darwin, not some sort of sordid discovery about someone entering random numbers into a spreadsheet. In 2008, Eliezer Yudkowsky wrote about The Beauty Of Settled Science: If you only care about scientific issues that are controversial, you will end up with a head stuffed full of garbage. The media thinks that only the cutting edge of science is worth reporting on. How often do you see headlines like “General Relativity still governing planetary orbits” or “Phlogiston theory remains false”? So, by the time anything is solid science, it is no longer a breaking headline. “Newsworthy” science is often based on the thinnest of evidence and wrong half the time—if it were not on the uttermost fringes of the scientific frontier, it would not be breaking news. Scientific controversies are problems so difficult that even people who’ve spent years mastering the field can still fool themselves. That’s what makes for the heated arguments that attract all the media attention. Worse, if you aren’t in the field and part of the game, controversies aren’t even fun. Don’t be embarrassed to read elementary science textbooks, either. If you want to pretend to be sophisticated, go find a play to sneer at. If you just want to have fun, remember that simplicity is at the core of scientific beauty [...] A steady diet of science news is bad for you: You are what you eat, and if you eat only science reporting on fluid situations, without a solid textbook now and then, your brain will turn to liquid. Psychology isn’t centrally the new paper in Annals Of Recently-Breaking News saying that an n=5 study showing that large portion sizes increase support for terrorism. Psychology is centrally ideas like brain waves, GABA receptors, reinforcement learning, twin studies, and connectionism. People who think differently are worrying too much about BREAKING NEWS!!!, and should stop. The key distinction isn’t “recent research in social psychology” vs. “recent research in cognitive/bio/behavioral psychology”, as my essay last week unfortunately implied. It’s recent research in general vs. the deposit of settled science, battle-tested hypotheses, and carefully-earmarked speculation. And part of the reason social priming in particular was such a disaster was that it defied that heuristic, building itself up over hundreds of studies until it approached or even entered the pantheon of settled science - before collapsing (5-HTTLPR was also sort of like this). This isn’t a claim that settled science is always right - Freud was “settled science” for a long time - just that there’s an intuitive distinction between the level of credence you should have in the existence of power posing vs. the existence of Broca’s Area. (I compounded this error by calling the last post “Psychology Research Is Mostly Fine”, which suggested I was talking about the new research rather than the settled science. I actually meant to distinguish between research-psychology-the-field vs. clinical-psychology-aka-therapy, but this framing unintentionally pushed against the point I wanted to make) Some commenters on the previous article understood this point, but challenged its weight. It’s very cool, they said, to know how many neurons are in which brain lobe, but the main way that Psychology affected their lives was through bad clickbait studies used to buttress dumb policies; some p = 0.049 study says that exposure to microaggressions makes minorities’ brains shrivel into raisins, and now their company has to implement punitive DEI or be sued for hazardous work conditions. I won’t dispute this as an accurate description of how the sausage gets made, but it’s worth examining the trains of thought that connect this observation to a campaign against psychology in general: The dumb woke psychology was wrong and bad, and I don’t have good heuristics for distinguishing dumb woke psychology from other psychology, so I’m going to assume it’s all wrong and bad. The dumb woke psychology was wrong and bad; it seems useful to punish/discredit psychology as a whole to assist my campaign against it, so for propaganda purposes I will try to discredit psychology as a whole. To people in the first camp, my response is: come on, your heuristics aren’t that bad. “Microaggressions makes minorities’ brains shrivel up like raisins” is in the woke category; “the hippocampal theta rhythm seems to be associated with both memory and pathfinding, suggesting an unexpected yet surprisingly compelling relationship between the two” is in the not-woke category, don’t play dumb here. To people in the second camp, my response is: deliberately exaggerated propaganda campaigns are bad and this is a confession, not an excuse. Inability to view science through anything but a political lens was what got us into this problem; doubling down on it is a temporary solution but a recipe for permanent disaster. If you pronounce entire fields of science to be acceptable collateral damage in your campaign against bad political actors, you will alienate not just scientists but patients, clinicians, and general lovers of truth. Instead, you can say the thing you mean - that woke partisans shouldn’t try to occupy and exploit the otherwise-noble science of psychology for their own political gain - and wage the same campaign with a halo rather than a comic-book-villain goatee. From the font of oracular wisdom that is Weird Sun Twitter: [ Vessel Of Spirit@VesselOfSpirit i love you all conditionally but i love the good part of you unconditionally. even if it becomes a very small part 2:11 AM · Jan 22, 2015 1 Reply · 5 Reposts · 29 Likes ](https://x.com/VesselOfSpirit/status/558084551772471298) This is how I feel about psychology1, too, but with a touch more optimism. The good part of psychology is enormous, a hoard of endless treasures. You just have to look past the headlines! 1 To play devil’s advocate - should one always be so magnamious? Astrology? Phrenology? These seem different in that their entire orientation was flawed from the start; they didn’t simply fail to find the correct constellation-personality connections, the whole project of searching for connections between constellations and personality was doomed from the start. More difficult might be asking the same question about education research, which is notoriously bad. I don’t know enough about education research to know if there’s some settled science of correct and enlightening results lurking in the background beyond the day-to-day froth of poorly-conducted and politically-motivated studies. I think if it’s 90% bad, 10% good, it’s correct to call it bad as a compact way of communicating a useful truth; I think psychology is better than that, but admit it’s a tough judgment call.
What to Eat and What to Avoid for Optimal Gut Health
Gut health can impact everything from sleep to the immune system, so Dr. Roshini Raj, associate professor of medicine at NYU Langone Health, shares her recommendations for preserving your gut microbiome. She shares the signs of an unhealthy gut, and what to eat to improve it. Dr. Raj also shares her tips for avoiding cyclosporiasis.
A simple supplement could help the immune system fight cancer and viruses
Low arginine levels may allow cancer cells and viruses to slip past the immune system by reducing production of a crucial cellular warning protein. In mice, arginine-rich diets led to fewer colon tumors and milder viral infections, suggesting a simple supplement could have powerful therapeutic potential.
6 Health Benefits of Papaya
Papaya contains vitamins A and C, which help support immune and eye health. Its fiber helps with digestion and may decrease heart disease risk.
'Natural Protection From Asthma And Allergies': Scientists Isolate Bacteria Behind The Immune System Farm Effect
A bit of dirt can be good for you.
Scientists may have found a way to prevent statin muscle pain
Scientists have identified an immune response that may explain why statins cause muscle pain, weakness, and exercise intolerance in some people. The finding could eventually lead to treatments that protect muscles while preserving the drugs’ lifesaving cardiovascular benefits.
Inflammation may trigger persistent 'out-of-body' experiences, emerging research hints
Researchers are investigating whether immune dysfunction can help explain dissociative disorders.
Overlooked plant proteins may boost gut health
Plant-based diets are good for you. They promote gut, immune, metabolic and cardiovascular health, in part by cultivating a diverse community of intestinal bacteria. These benefits have long been known ...
'Make North London Brazilian'
Just when I was starting to get disillusioned with Andrea Berta's transfer barbecue, he reveals a Wagyu steak was sizzling away all along, hidden from view. Spurs have just spent £100m apiece on two midfielders who are half as good as Declan Rice. Which begs the question, is the Premier League now rich enough as to be immune from consequences?
A single sauna session sends immune cells surging
A single 30-minute sauna session may briefly put the immune system on higher alert. Finnish researchers found that sauna heat, paired with a short cold shower, increased every type of white blood cell circulating in the bloodstream, including key infection fighters such as neutrophils and lymphocytes.
Scientists decipher how T cells sense enemies—such as cancer—at point of contact
Every encounter between a T cell and a potential target—especially when that target is a developing tumor—begins with a rapid series of molecular decisions. Within seconds, the immune cell must determine ...
AI mental health chatbots feel empathetic, but safety evidence still lags
Immune dysregulation may contribute to depression, schizophrenia, bipolar disorder, and anxiety through chronic inflammation, altered neuroimmune signaling, genetic susceptibility, and stress-related epigenetic changes. Evidence also suggests that biologically defined patient subgroups may benefit from more precise, immune-informed approaches to diagnosis and treatment.
A hidden Alzheimer’s tipping point may decide who gets dementia
Scientists have identified a possible tipping point that helps determine whether Alzheimer’s-related brain changes lead to dementia. The key may lie in how the brain’s immune cells respond to plaques and tau, offering a promising new target for treatments designed to extend cognitive resilience.
Does this disappearing organ hold the secret of longevity?
Scientists are increasingly focused on the thymus, an immune gland that naturally becomes less active with age.
How eczema and acne can affect your mental health
Scientists are uncovering a complex communication network linking the skin, immune system, and brain—one that could transform how chronic skin disease and mental health are treated.