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Crowell & Moring Adds Veteran DOJ Health Care Litigator Jeff McSorley in Washington, D.C.
Jeff McSorley, a first-chair trial lawyer with 20 years of litigation experience including a decade as senior trial counsel in the DOJ Civil Division's Fraud Section, has joined Crowell & Moring's Health Care Group in Washington, D.C. He led more than 70 FCA investigations at DOJ, securing more than $500 million in recoveries for the United States.
Dementia risk may be linked to seemingly harmless daily habit, new research suggests
Even naps under 30 minutes raised dementia risk 40% in a Johns Hopkins Bloomberg School of Public Health study of nearly 1,000 older adults.
New York Yankees Linked to Blockbuster Catcher Trade
The New York Yankees have been connected to a huge trade for a star catcher.
Tigers Linked to Blockbuster Trade for Rangers' deGrom
The Detroit Tigers target a seasoned ace to anchor their rotation while the Texas Rangers weigh shedding a massive contract.
The Daily Roundup: Kalispell Business Improvement District Looks to Replace Street Furniture Downtown
On Friday, we officially published our 2026 Election Guide, linked here, at the bottom of this newsletter and in the “Editor’s Picks” section of our website, where it will live throughout the rest of the election cycle.
Canada wants to expand its LNG business. Critics raise red flags
As Canada’s LNG exports grow, critics raise concerns over human rights abuses linked to major corporate investors.
Phillies Get Update On Triple Crown MVP Free Agent Target
The Philadelphia Phillies are linked to a superstar infielder who will officially become a free agent option in the offseason.
Could 'body clocks' play a role in depression? Study proposes a new 'circadian' subtype
Researchers propose a new subtype of depression linked to body-clock patterns.
Birth centers are linked to better health outcomes, research shows, but 10 states have none
Birth centers are an option for those with low-risk pregnancies and are correlated with more positive health outcomes, but 10 states do not have any birth centers at all, and more could be built with certain state policy solutions and different models of care, a new report suggests.
Sahara Ray, model once linked to Justin Bieber, dies at 34
NEW YORK — Model Sahara Ray is dead at 34. The family of the Australian fashionista once linked to Justin Bieber told TMZ that Ray died Sunday night “surrounded by
Embattled cannabis business CEO accused of failing to pay $1.5 million in federal payroll taxes
Her company, La Mota, is linked to the 2023 resignation of former Oregon Secretary of State Shemia Fagan.
Georgia health officials warn of possible measles exposure at restaurant as cases climb
A person linked to a measles investigation visited a Georgia restaurant while infectious, and state health officials are urging customers to check vaccination records.
Childhood adversity linked to billions in health and economic costs
The health effects of childhood adversity carry a huge economic burden, according to new research across Wales and England.
Study identifies protein regulator of tau linked to Alzheimer’s disease
The accumulation and tangling of tau proteins is a well-known feature of Alzheimer’s disease. Less understood is how different forms of tau are regulated and what happens to that balance as the brain ages and neurodegenerative disease develops. A study from The University of Texas at San Antonio’s Health Science Center published in July […]
A Dragon’s Den: Does Gender Really Matter in Support for Businesses?
When 4,500 members of the public were asked to consider investing, the business idea mattered more than whether a man or a woman was behind it
Most Seoul National University admits who decline enrollment are science and engineering students
Experts say the decision not to attend the prestigious university can be linked to a continued preference for medical school.
Your age may not tell the whole story about your health, but your blood could
Researchers analyzed plasma metabolites from 18,476 individuals aged 1 to 96 years and developed two metabolomic aging measures to assess biological aging, chronic disease, and mortality risk. Accelerated metabolomic aging was associated with greater risks of chronic disease and death, while a separate mortality-linked measure provided additional information about health status and disease burden beyond conventional clinical assessments.
'A uniquely direct route that might cause damage': Scientists uncover link between air pollution and eye diseases like glaucoma
A review of 41 studies found that higher exposure to air pollution was linked to greater odds of glaucoma and cataracts, with PM2.5 pollution showing the clearest association.
Scientists uncover 3 key brain pathways linked to lasting depression relief
Researchers have uncovered three brain pathways linked to lasting improvements in people receiving deep brain stimulation for severe, treatment-resistant depression. They also discovered that patients who failed to improve after two years shared a striking pattern: insufficient stimulation of a crucial brain connection. The findings suggest that millimeters in electrode placement could make a major difference in treatment outcomes.
Scientists Uncover a Hidden Factor That Could Change How We Manage Diabetes
Timing may matter in insulin-treated type 2 diabetes; patients with the steadiest daily rhythms were 2.3 times as likely to meet blood sugar goals, while afternoon activity was linked to smaller swings. People with type 2 diabetes who use insulin need to keep blood glucose from climbing too high or falling too low. In a
Even LinkedIn is getting tired of your AI-written posts
LinkedIn is upping its fight against generic, low-quality AI posts on its platform.
Famous supernova that lit up skies in 1181 is now full of mysterious knots — Space photo of the week
Pa 30, linked to a supernova seen in 1181, reveals chains of tiny gas knots in a new image from the Gemini North telescope in Hawaii.
Kenya’s Ebola cases rise to 7, including health workers who cared for the first patient
Three Kenyan health workers have tested positive for Ebola after caring for the country's first confirmed case, according to the Health Ministry. Another person linked to the initial case also tested...
Kenya’s Ebola cases rise to 7, including health workers who cared for the first patient
NAIROBI, Kenya (AP) — Three Kenyan health workers have tested positive for Ebola after caring for the country's first confirmed case, the Health Ministry said Saturday. Another person linked to the fi...
Intel confirms Razor Lake-AX for 2028 with 700 TOPS AI performance
Intel's Razor Lake-AX will target humanoid robots in 2028. Earlier leaks linked the processor to 16 or 32 Xe3P graphics cores and on-package memory.
Microplastics Have Been Linked With Myriad Human Health Problems. Scientists May Have Finally Figured Out How They Harm the Body
Lab experiments suggest that tiny bits of plastic can react with water inside us to produce highly reactive molecules. They can lead to damaging oxidative stress and inflammation
Microplastics Have Been Linked With Myriad Human Health Problems. Scientists May Have Finally Figured Out How They Harm the Body
Lab experiments suggest that tiny bits of plastic can react with water inside us to produce highly reactive molecules. They can lead to damaging oxidative stress and inflammation
Plague is stoppable. The next health threat may not be.
The word plague is scary. Centuries ago, the Black Death killed tens of millions of people and changed the course of history. Plague still kills people around the world, and the word still evokes catastrophe. New fears of plague surfaced on October 2, when a lab worker in Irkutsk, Russia, died of pneumonia. Reports suggested that she may have contracted plague through a laboratory exposure. Understandably, people were alarmed. On October 7, the World Health Organization called for the Russian Federation to be transparent about what it knew. WHO issued an update on October 10. Russian authorities told WHO that testing did not identify plague and that investigations found no laboratory release. WHO said confidence in its risk assessment remained limited and that further clinical, epidemiological, and laboratory information was needed. The cause of the woman’s illness remains unknown, and WHO says a laboratory-associated exposure cannot be excluded. As I explained in a recent interview, this incident is very unlikely to lead to a pandemic. Plague is still active, including in the U.S., which sees a handful of cases each year. But it is a disease we can prevent and treat. Plague doesn’t spread readily, and it responds to antibiotics. The standard response—isolate the patient, trace contacts, and administer antibiotics and monitor for symptoms among contacts for seven days—works. We have even planned for antibiotic-resistant plague. At CDC, we developed a playbook for antibiotic-resistant plague and ran exercises on how to find and stop it. CDC guidance anticipates engineered resistance and recommends two different classes of antibiotics if there’s reason to suspect it. There is no evidence that resistance—or even confirmed plague—is involved in this incident. We have thought through how to address plague, but we’re not ready for the next major health threat that emerges from a lab or from animal spillover to humans. What should concern people is how little stands between the world and the next pathogen to get loose. Since peak COVID, epidemic preparedness has fallen off the political agenda, but the risk is greater than ever. More labs handle dangerous pathogens with more ways to make those pathogens deadlier, and more people live and work in close contact with animals. There are actions we can take now: We need better lab safety in every country. The number of labs that work with dangerous pathogens has increased worldwide over two decades, but there’s no enforceable international standard and no inspection regime; the Biological Weapons Convention, fifty years on, still has no verification mechanism. Labs that study dangerous germs need strong safety systems, training, and oversight. We need to reduce spillover events. Three in four emerging human infections start in animals, and there’s a lot we can do to reduce spillover risk, but the world is doing very little of it. Live-animal markets are one place to act. For instance, closing live-bird markets helped control H7N9 influenza in China. Reducing opportunities for people to encounter infected animals can prevent infections before they become outbreaks. In The Formula for Better Health, which is now out in paperback along with the hardcover, Kindle, and audiobook versions, I argue that labs do too many risky experiments with too many dangerous pathogens in too many institutions, and that every experiment should first answer one basic question: Is the likely benefit greater than the risk? Spillover risk can also be reduced: In the book, I discuss how Brazil cut its deforestation rate by 70% from 2004 to 2012 while increasing agricultural production and reducing risky contact between people and forest animals. We need faster detection and response. Delay costs lives. Strong surveillance, good labs, and trained responders can turn a single case into a small cluster of infections instead of an epidemic. Resolve to Save Lives has worked for nearly a decade to help countries find and stop outbreaks faster. The 7-1-7 target, which Resolve to Save Lives developed with partners in Uganda and elsewhere, provides a clear standard: detect within 7 days, notify within 1 day and complete all essential early response actions within 7 days. In Uganda’s Kasese district, for example, a review of a measles outbreak using 7-1-7 identified shortages of accessible funds, fuel, and vehicles that delayed the response. District leaders established funds they could access quickly. When, a few months later, the Crimean-Congo hemorrhagic fever appeared, the district detected it in three days, notified authorities in one, and mounted an effective response in two. Only one case was confirmed, and the patient survived. Because funds were available before the emergency, authorities were prepared and able to act. This kind of preparation can’t wait until the next crisis begins. Plague is an old disease we that know how to stop. The next threat may be harder to recognize, harder to treat, and easier to spread. Safer labs, less risk of spillover, and faster outbreak detection and response need sustained investment now, while we still have time to prevent the next emergency. Share
Democrats hope a rematch can dislodge Trump loyalist Perry in Pennsylvania
Few Republican members of Congress in swing districts may be more closely linked to President Donald Trump than Scott Perry of Pennsylvania.
Democrats hope a rematch can dislodge Trump loyalist Perry in Pennsylvania
Few Republican members of Congress in swing districts may be more closely linked to President Donald Trump than Scott Perry of Pennsylvania.
Ultra-Processed Foods and the Aging Brain: What Does the Science Say?
Eating more ultra-processed foods has been linked to increased risk for dementia and Alzheimer's disease, as well as other non-brain health effects, including diabetes and cancer. But why do these foods affect our brain health?
AI study of 101,000 patients links brown fat to heart and mental health
In a retrospective analysis of PET-CT records from 101,243 patients, researchers found that detectable brown fat was associated with lower prevalence of cardiometabolic and psychiatric conditions, while greater activity, particularly in the axillary region, was linked to more favourable metabolic outcomes. Medication screening identified losartan, which increased brown fat thermogenic activity in laboratory experiments and energy expenditure in mice, although its effects on human brown fat remain unproven.
Recent Suicide Attempts and Prior Mental Health Hospitalization Linked to Further Risk for Attempts in Adolescents
A recent suicide attempt, prior mental health hospitalization, nonsuicidal self-injury, and hopelessness are tied to subsequent suicide attempts among teens who screen positive for suicide risk.
Yankees Expected to Target $6.8 Million Former Reds Slugger
New York Yankees GM Brian Cashman is linked to a cost-effective free agent slugger to help improve his team's offense. The post Yankees Expected to Target $6.8 Million Former Reds Slugger appeared first on HEAVY.
Scientists restore memory-linked neuron function in Alzheimer's mice
Researchers were able to restore the function of neurons linked to cognitive function and information processing in mice that mimic key features of Alzheimer's disease, showing early promise for the development of a similar targeted therapy in humans.
Mismatch between mothers' words and facial expressions linked to poorer mental health in children
A study by Cardiff University's School of Psychology, published in Scientific Reports, has revealed how the emotional environment created by mothers can impact children's mental health.
Online Sports Betting Linked To Rise In Depression And Anxiety Treatment
By HealthDay Staff HealthDay ReporterTHURSDAY, Oct. 15, 2026 (HealthDay News) — More people are receiving treatment for depression and anxiety in states that legalized online sports betting. Researchers from Johns Hopkins University reviewed health insurance records from 2016 to 2023, comparing ...
Transferra Launches Visa Cards for Business and Private Clients
Transferra Transferra Launches Visa Cards for Business and Private Clients Transferra London, UK, Oct. 15, 2026 (GLOBE NEWSWIRE) -- Transferra Launches New Virtual And Physical Visa Cards For Business Accounts And For The People Behind Them A black Visa Business card for company spending and a Visa card in purple-to-silver gradient for personal use, each issued as a virtual and a physical card, linked directly to clients' Transferra accounts. Transferra today announced the launch of new Visa pay
Best foods for reducing dangerous belly fat and protecting heart health
Belly fat and visceral fat are linked to serious health issues. A doctor shares how lean protein, fruits and vegetables, and healthy fats can help reduce stomach fat.
Ozempic and Wegovy linked to rare risk of sudden vision loss
Popular diabetes and weight loss drugs such as Ozempic and Wegovy have been linked to a slightly increased risk of a rare condition that can cause sudden, potentially permanent vision loss. Although the risk remains very low, Rutgers researchers say the findings warrant attention as millions of people turn to GLP-1 medications.
Your Business Probably Has More Data Than Insight by Nathan Tayloe
Most businesses know more about themselves than they ever have. Leaders have access to financial reports, sales pipelines, customer data, employee metrics, website analytics, and dashboards for almost every part of the organization. CRMs track every stage of the sales process. Marketing platforms report results in real time. AI can analyze and summarize enormous amounts of information in seconds. Yet I've sat in plenty of meetings where all of that information is available, and some of the most important questions are still surprisingly difficult to answer. What's actually working? Why are customers choosing us? Where are we losing opportunities? What should we do differently? Having the data and understanding what it means are two very different things. More Information Doesn't Always Create More Clarity Over the past decade, businesses have invested heavily in visibility, and that's a good thing. We can understand performance with a level of detail that would have been unimaginable not long ago. But there's an unintended consequence. The easier something becomes to measure, the easier it is to assume it must be important. Website traffic goes up, so that looks positive. Leads increase, so marketing appears to be working. Sales activity climbs, so the pipeline looks healthy. Maybe. The numbers tell us what happened. Understanding why it happened, whether it matters, and what we should do next still requires judgment. Not Everything That Matters Fits on a Dashboard Consider a customer who ultimately contacts your company through Google. The data may attribute that lead to search. What it may not show is that the customer heard about you from a colleague six months earlier, saw your company mentioned in an industry publication, followed one of your employees on LinkedIn, and read several reviews before finally searching for your company. Google may have produced the click. It didn't necessarily create the decision. This happens throughout a business. Some of the things that matter most are difficult to reduce to a single metric: Why your best customers stay Why talented employees choose your company Why a prospect trusts one provider over another Why one service is gaining momentum while another isn't Why the market perceives your business the way it does Data can help answer those questions, but it needs context. Better Decisions Start With Better Questions One of the easiest traps for leaders is starting with the information in front of them rather than the decision they're trying to make. Instead of opening a dashboard and asking, "What does the data show?" it can be more useful to start with a different set of questions: What are we trying to understand? What decision are we trying to make? What would we need to know to make that decision confidently? That changes the role of data. Instead of looking at every number available and searching for meaning, you're using information to understand something specific about the business. Information Still Requires Judgment More sophisticated analytics and AI will continue to give leaders access to better information, faster. That's valuable, but I don't think it reduces the importance of experience and judgment. If anything, it increases it. Someone still has to decide which numbers deserve attention, which patterns matter, what context might be missing, and when the data isn't telling the whole story. The goal isn't to know more about your business simply because you can. It's to understand your business well enough to make better decisions. Good data can tell you what happened. Good leadership has to decide what it means. — Learn more about how we help organizations turn business, customer, and marketing insights into smarter strategies at tayloegray.com, or reach out directly at nathan@tayloegray.com.
Ubisoft plans cuts at German studios, adding to wave of workforce reductions
Ubisoft is planning to reduce its workforce in Germany, where it operates a trio of studios, by about 100 workers, Game File has learned. The company wants to offer employees buyouts to, should enough people accept, avoid having to lay anyone off. “In Germany, we initiated discussions with the Works Council last week regarding a proposed voluntary departure plan across Ubisoft Dusseldorf, Ubisoft Berlin & Ubisoft Mainz,” a company rep told Game File. A “works council” is a union-like group representing employees. “The voluntary plan is the primary measure being proposed to support the intended organizational changes,” the Ubisoft rep added. The company declined to confirm the scale of the potential headcount cut. Of the impacted studios, Mainz might be the best known to the public. It leads development of the Anno series and shipped the well-reviewed strategy game Anno 117: Pax Romana in November 2025. Berlin and Dusseldorf operate as support studios within Ubisoft’s creative network. Berlin recently supported the development of Rainbow Six Siege and the Rayman Legends Retold remake. Dusseldorf also contributed to those projects, as well as The Settlers and Ubisoft-branded escape rooms. Dusseldorf is the biggest of the three studios, with some 400+ workers, compared to just over 100 at the other two, a source familiar with the reductions and the teams told Game File. More than half of these new reductions of about 100 people are expected to happen at Dusseldorf. The planned cuts were announced at a town hall for the German studios on Tuesday of last week. In an email follow-up, the studio group’s managing director, Benedikt Grindel, said the cuts were intended to “best position our German studios for the future... with a clearer focus on their role, capabilities and organizational setup needed for the work ahead.” The email was an echo of the past. In January 2025, Grindel had emailed the Ubisoft developers in his region (or studio “zone”) to explain that a round of 185 cuts at the time, including about 65 at Dusseldorf, were “essential to improve our operational efficiency and ensure the long-term sustainability of our studios, the zone and the company.” A half-decade of continued job cuts Ubisoft has been aggressively cutting its headcount for years. At the end of September 2022, it had 20,729 workers. By the end of March 2026, that total was down to 16,590. Studio management is trying to trim costs as it grapples with a changing industry and a drought of releases, let alone hits. The company announced earlier this year that it had reduced its costs since 2022 by “nearly €325 million” ($362m) and planned to lower them through 2028 by another €180 million ($200m). In June the company said it was closing down its Winnipeg and Belgrade studios and cutting roles in its Barcelona team. Even commercial and creative success hasn’t spared studios from this ongoing company-wide contraction. As Game File was nailing down details around the proposed cuts in Germany, Ubisoft management was informing workers of cuts in its Singapore studio, which shipped a hit remake of Assassin’s Creed IV: Black Flag this past July. Some 70 positions in Singapore are being eliminated “to align the studio with upcoming production needs,” per a company rep’s statement to Game File. In early 2024, a large team in the Singapore studio launched the multiplayer pirate game Skull & Bones. It performed poorly but has been supported with regular content updates since. Many of Ubisoft’s studios around the world are heavily subsidized via regional grants and tax breaks. Singapore had been among them for years, but received no such local assistance in the 12 months ending this past March. News of the Singapore cuts broke today alongside word that Ubisoft is also proposing the closure of RedLynx, pending negotiations with officials. The Finnish studio behind the motorbike series Trials was founded in 2000 and sold to Ubisoft in 2011. As reported by VGC (and corroborated by Game File), Ubisoft management told employees it could not come up with a new, sustainable assignment for RedLynx. The 2025 workforce at Ubisoft Dusseldorf were straight-up cuts. This time, Ubisoft is hoping the reductions at its trio of German studios will largely come from workers taking a payout to leave. The company offered such voluntary dismissals at its Massive Entertainment studio (The Division) a year ago. For the German studios’ buyouts this time around, Ubisoft and the Works Council had discussed a formula that’d pay a worker’s monthly salary multiplied by 1.5 and by the number of years they’ve worked at the company, according to Game File sources. The formula is still subject to negotiations with the Works Council and has not yet been part of an official offer to workers. It could be adjusted up or down, and it could be supplemented with additional bonuses. Asked about the floated payout formula, a Ubisoft rep told Game File, “The terms of a potential voluntary departure program remain subject to negotiation with employee representatives. No final agreement has been reached, and we won’t comment on specific proposals while discussions are ongoing.” Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Epic’s AI adventures Epic Games (Fortnite, the Unreal engine) is all-in on using AI to try to transform the way it makes video games and game-making tools. It’s leaders appear to be undeterred by any resistance among gamers and some game developers around generative AI—and instead emboldened by advances, particularly in AI-assisted programming. A recap of the last three days: On Monday, Bloomberg reported that Epic management told workers last week that development of an upcoming game combining Star Wars and Marvel characters would be “AI first.” Employees would be expected to use AI models such as Claude to code the game. A manager told Epic’s developers there would be “[n]o more hand-written code” and that art for the game would be “generated with full AI workflows,” per the outlet. Just ahead of that story running, Epic founder Tim Sweeney tweeted: “We have a huge pivot underway here at Epic, moving developers around to retool for maximum AI acceleration. The aim isn’t to do the same stuff with fewer people, but to enable everyone here to build MORE and BETTER stuff, and to bring the benefits to all teams using Unreal.” In a follow-up, Sweeney predicted that most game development processes would be at least three times faster a year from now than they were in January 2026, thanks to AI. To a person on X who told him he was failing to read the room, Sweeney said: “Much of the room wants it to be 2016 again, but it’s not. Our job, as the provider of tools and technology to much of the industry, is to design for the present that is and the future that will soon be.” On Wednesday, Epic announced it was releasing a faster launcher for its Epic Games Store marketplace. It did so by stating in a blog post as clear as could be that the launcher is an AI-enabled, vibe-coded project: Programming is hard. So, instead of doing that, we vibe coded a new Epic Games Launcher that’s way faster and more responsive than the current one, and has a new look. Programming is hard? That was unexpected phrasing from a company founded by a legendarily great programmer. Back in 2011, Sweeney told me that he’d picked up programming quickly as a kid and rejoiced at the power it gave him. “I could look at any program that anybody else had written and, with enough effort, build something cooler.” Item 3: The Xbox Labs experiment (and one of the people behind it) Microsoft’s Xbox division, which is flooding the zone with announcements lately, yesterday revealed a new internal tech-tinkering team called Xbox Labs. In the words of Xbox boss Asha Sharma Labs is “a small group of game makers, engineers and scientists whose job is to turn emerging ideas into things our players and developers can experience.” Conventional wisdom coming out of the announcement is that Labs is a team that’ll focus on ideas driven by generative AI. In her announcement, Sharma cited some of the dizzying achievements in tech and gaming over the past month as AI agents and other AI tools have been deployed to swiftly figure out how popular games work, then rebuild them and mix them up. She mentioned seeing ”games rapidly decompiled and rebuilt to run on hardware they were never originally designed to support” and said “[p]erhaps more surprisingly, we’ve seen many of the biggest games in the world have been remixed into the source code of another.” (Minecraft plus Elden Ring, for example, or Fortnite + Super Monkey Ball + Overwatch + Diablo + others.) Sharma also cited the work of Windows PC games being ported to run in browsers, a seeming reference to a recent AI-assisted fan port of Halo. Or perhaps Call of Duty or GTA. Sharma didn’t use the specific term “AI” in her memo, but she came close, citing AI “agents” and their potential for game-making tools that Labs could help craft: I think XBOX has an important role to play here. Coding became the first major workload for agents because they can write, run, and test software. Games share many of those same properties, and people spend more than 72 billion hours a year playing XBOX games, roughly five times the estimated time spent writing code worldwide. We’ve spent 25 years learning how to make great games, and I want our game makers to help shape what these new technologies make possible. As we learn, we’ll share the tools we build with developers across the industry, just as we always have. When I asked an Xbox rep if Labs was an AI-centric team, they said genAI was not the focus, describing it as having a broader mandate for using new tech in new ways in gaming. As an example, they pointed to Xbox’s recently launched disc-to-digital gaming usage rights program. Microsoft didn’t specifically name anyone involved full-time in Xbox Labs yesterday, but on social media and LinkedIn, I spotted Adrian Mato IDing himself as leading the creatio of tools at Labs and talking up the launch. Mato first caught my attention in late September, when he said on X that he was “starting to build a new team at Xbox focused on products and tools for how games get built and distributed as agentic tools become more capable.” At the time, he framed AI-based tools as a supplement to traditional game dev tools. “I don’t think we need to replace them,” he said. Since then, he’s publicly shown interest in AI and in games. He’s recently spent some of his X feed marveling at the power of AI agents and praising the lighting in the latest Gears of War. Following the Labs announcement yesterday, he enthused about the Xbox Labs’ stylish landing page. He wrote: “We built some fun tools to art-direct shaders in real time, experimented with interactive ASCII art, and sprinkled in lots of tiny details. “Move your mouse to leave a colorful trail that reveals the original footage, or interact with the video to trigger bursts of particles. “A lot of love went into making it all feel just right. “More to come”
10 health conditions may be linked to Alzheimer's years before diagnosis
Depression, vertigo, headaches and stroke were among conditions linked to early-onset Alzheimer's disease years before diagnosis, a Finnish study suggests.
Smith Entertainment Group shares vision for reimagined Salt Lake City downtown
Smith Entertainment Group has unveiled the plans for a 4-block, 35-acre development that’s linked to the renovation of Delta Center and will reshape Salt Lake City’s downtown.
IMDB Launches Features From LinkedIn Like Connections
The entertainment industry platform will let pro users add connections and publicly endorse each other's work.
Neighborhood conditions linked to childhood cancer survivors’ long-term health
Discover how the St. Jude Lifetime Cohort Study uncovered community-level factors influencing chronic health condition risks, and how that can improve care.
PUBLISHER’S NOTE: Busy Fall
We have a busy fall ahead of us—and that’s always good news. We like to stay busy. We’re working on two special annual publications: the CNY Business Guide and the CNY Winter Guide. Both publications are designed to reach specific audiences in the community. We’re excited about these new editions and would like to share a few details about them. Let’s begin with the Winter Guide. Winter can be challenging, but it also offers plenty to celebrate. The new CNY Winter Guide will help readers embrace the season and make it more fun and enjoyable. This year’s annual publication will feature an extensive calendar of events, compelling stories, and curated lists of things to do and see throughout the winter. This will be our 31st annual issue. It is one of the few publications—if not the only one—devoted exclusively to winter in Central New York. For advertisers, it offers a valuable opportunity to reach readers across the region. As we tell prospective advertisers, one ad works for them all season long. Rates start in the low $200s. The guide will be available at hundreds of high-traffic locations, including all Wegmans stores and select Price Chopper and Tops Friendly Markets locations. It will also be available online, with every ad hyperlinked so readers can click directly through to the advertiser’s website or Facebook page. Our network of drivers will also deliver the guide to hundreds of high-traffic locations several times throughout the winter. The publication will be out by Thanksgiving. The CNY Business Guide is a one-of-a-kind publication that many readers use as a reference. Unlike the books of lists published by business journals across the country, it comes in a glossy, full-color magazine format. It also ranks employers in four counties, with a particular emphasis on Oswego and Onondaga and substantial information about Cayuga and Jefferson. It is an ambitious project that requires extensive research, phone calls, careful fact-checking, writing and design. In short, it takes a great deal of work—and we’re glad to take on the challenge. The guide is widely distributed to business and professional readers throughout Central New York. The Business Guide gives companies an excellent opportunity to highlight their growth and expansion, showcase new products, and share other noteworthy developments. For readers, it provides a valuable snapshot of companies across the region, including what they do and who leads them. The guide will be published in early December. We invite companies to advertise in both publications. Advertising costs are relatively low, and each guide offers access to a broad audience across Central New York. Wagner Dotto is the editor and publisher of Oswego County Business Magazine.
Liverpool enquiry for 'fantastic' midfielder confirmed
Liverpool have been linked with a whole host of players ever since the 2026-27 season first kicked off. Most fans expected a complete rebuild of their first-team squad after their fifth-place finish l...
Laurel County Health Department investigation reveals over 50 reported cases of measles
The new reported cases are part of an investigation with the Kentucky Department of Public Health and are linked to several large households with limited community interaction.
Recent Philly gun violence sparks concerns over mental health
A deadly police shooting, the murder of a Philadelphia police officer, and the suicide of a man linked to a double homicide have sparked recent concerns over mental health and gun violence in Philadelphia. NBC10’s Tim Furlong has the details and speaks with a mental health expert.
Health officials suspect new measles outbreak, this time in Rock County
The cases are linked to each other but separate from a large ongoing outbreak in southwest Wisconsin.
RIP, homeOS
MacRumors was first to reveal the name "HomeView" last week, after discovering a trademark filing from a secretive shell company that we correctly suspected was linked to Apple. Apple was likely behind a "homeOS" trademark filing as well, but the company ultimately decided to stick with generic "HomeView software" naming, just like it refers to the HomePod's operating system as "HomePod software".
Katie Zacharia ends first White House press briefing after 14 minutes
Katie Zacharia took the lectern for the first time as White House press secretary on Oct. 13, but if you blinked, you might have missed it.
Trump-linked super PAC pulls funding from 2 House Republicans as GOP fights to keep majority
House Republicans face growing pressure as Trump-aligned MAGA Inc. pulls planned spending from Tom Kean and Marianette Miller-Meeks' districts.
Bethenny Frankel Reveals Launch of New Business Venture Bethenny Media
According to a series of new posts on LinkedIn, the reality TV veteran is staffing up the company with senior executives — including hiring a former staffer from Reese Witherspoon's Hello Sunshine.
GOP-linked group behind ads for socialist candidate in Ohio Senate race
A super PAC with ties to Republicans is spending hundreds of thousands of dollars to promote a third-party candidate for U.S. Senate in Ohio, in an apparent attempt to siphon voters from the Democratic candidate, former Sen. Sherrod Brown.
PAC linked to GOP firm is boosting Ohio socialist in Senate race
The socialist candidate says the effort is “deceiving” voters.
Study links environment and youth mental health
A new University of Canterbury-led study of almost 1 million young people in New Zealand shows the environments they live in may be linked to their mental health over time. Te Whare Wānanga o Waitaha ...
Having someone to talk to linked to better mental health among LGBQ+ teens
Gay or bisexual teens who have someone to turn to with a serious problem have significantly better mental health outcomes than those who don't, according to a new study from Tulane University researchers.
Science Snapshots: October 11, 2026
Three key science updates: 2024’s extreme, possibly normalizing rainfall; hypertension-linked osteoarthritis worsened by vasopressin; and an AI-proof checker solving Erdős problems autonomously.
Melbourne man linked to suspected flydubai hijacker condemns 'false accusations'
A Melbourne man whose Islamic community centre has been linked by prosecutors in the United Arab Emirates to the co-pilot who allegedly attacked the captain of a flydubai jet has
How Do Freedivers Cope With So Little Oxygen? Scientists May Have Found a Clue.
A small, unreviewed study linked freediving training to changes in brain connectivity, raising questions about adaptation to low oxygen.
Popular weight loss drugs linked to a surprising fingernail problem
Popular GLP-1 weight loss drugs, such as Ozempic and Wegovy, have been linked to unexpectedly high rates of nail detachment, hair loss, and scalp inflammation, with some problems occurring several times more frequently among users. Researchers found that weight loss alone could not fully explain the differences, suggesting there may be more to these overlooked symptoms.
Patrick Mahomes’ Former Teammate Linked as Chiefs Reunion Candidate
The Kansas City Chiefs are weighing their wide receiver options after injuries left the position short on depth, limiting Patrick Mahomes’ options in the passing game. The team’s Week 5 bye gives it time to evaluate the roster and explore potential reinforcements. Former Chiefs WR Justin Watson is among several receivers Kansas City is considering […] The post Patrick Mahomes’ Former Teammate Linked as Chiefs Reunion Candidate appeared first on Gridiron Heroics.
Scientists Say the Secret to a Happier, Healthier Society May Begin in Childhood
How children are raised may matter for social well-being worldwide, with surveys across three culturally different countries linking supportive childhoods to adults’ trust and sense of belonging. At home, a child seeking comfort depends on a caregiver’s response, while time for free play offers room to explore. A University of Nottingham-led study linked these experiences,
Rubio pledges US cooperation in Marine-linked murder case
A US Marine stationed on Okinawa has been arrested on suspicion of killing a 39-year-old woman.
Bears linked to trade reunion with All-Pro edge rusher at fifth-round pick price tag
This veteran All-Pro edge rusher would make a lot of sense for the Bears at this price.
Friedkin place focus on Roma amid Everton sale
The Friedkin family has put Everton, acquired in 2024 through its holding company, up for sale. According to Il Messaggero, this decision is linked both to economic reasons and to the potential diffic...
Packers Linked to Titans RB to Bolster Rushing Attack
The Green Bay Packers have to do something to get the rushing game going this season.
Digital detox how-to; artificial intelligence in nursing; when to see your doctor about GI issues; plus other stories with Vanderbilt Health sources
Prevention interviewed Beth Malow, MD, Professor of Neurology and Pediatrics in the Vanderbilt Sleep Division, about a study that found insomnia is linked with a 26% higher risk of stroke and 28% higher odds of hospital admission. William Schaffner, MD, Professor of Health Policy, was quoted by Parade about the most common COVID symptoms people are experiencing right now, HealthLeaders interviewed Deonna Taylor, PhD, ACMP, RN, Vice President and Chief Nursing Officer, Adult Ambulatory Nursing, about how artificial intelligence will affect nursing practice. The Wall Street Journal interviewed Joseph Schlesinger, MD, Professor of Anesthesiology Critical Care Medicine, for a story about ICU alarms keeping patients from getting sleep and creating alarm fatigue for nurses. Cathy Eng, MD, Executive Director of the Young Adult Cancers Program was interviewed by the The New York Times about GI symptoms that patients should not ignore. Heather Jackson, PhD, APRN, Administrative Director, Advanced Practice, was interviewed by Fox17 about nurse practitioner roles becoming the fastest growing job in the next 10 years. Prevention interviewed Jonah Garry, MD, Assistant Professor of Medicine, Division of Cardiovascular Medicine, for stories about how sleep impacts your heart health and how to do a digital detox.
Netflix’s Summer of Bummer
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) Today, I’ve got a guest post from longtime friend of the newsletter, Brandon Katz. I’ve been trying to find time all summer to look at Netflix’s straight-to-streaming film slate, but between a pre-planned trip and Nielsen moving up their streaming data timeline, I’ve been swamped. So I reached out to Brandon, one of my favorite fellow analysts, to write about it. And I feel like he captured the tone and data focus of the newsletter perfectly. You can connect with Brandon on LinkedIn and Twitter. Enjoy! Don’t worry, folks. You’re in safe hands with me. To ease any anxieties about an interloper in ESG’s domain, I’ll start by stealing one of his best framing devices: headlines. Box office flops are covered in the same way the Teenage Mutant Ninja Turtles eye pizza: with cartoonish insatiability. I would know. I’m a former reporter who wrote nearly identical headlines: Yet, intentionally or not, streaming misses get treated with kids gloves, filtered through a rosy lens: In the last six years, U.S. streaming viewership has become nearly as transparent as the box office, but the data often arrives weeks later, in a number of less intuitive metrics, and with nary an official budget to be found. This plays into the Wall Street-whispering narratives major streamers have been cultivating for years. They get a pass in a way that theatrical studios simply don’t. Subscribe Netflix’s Summer Slate Not a single Netflix original film released between May and August this year opened above 20 million U.S. TV hours, per Nielsen. That benchmark usually serves as the EntStrategyGuy’s floor for a streaming hit on Netflix. None of these films enjoyed a hit-cementing single week of 20-plus million hours during their runs. Netflix’s two best films were true crime docs, Maternal Instinct (16.5 million hours) and The Crash (19.7 million), the best overall week for a film this summer. Great for most other streamers, but not necessarily what we’re used to seeing from Netflix. For an overly-dramatic comparison, Happy Gilmore 2 opened last summer to around 47 million hours (celebrity cameos, baby!). Zooming out, the picture looks even worse. In 2026, Netflix’s five biggest scripted summer films posted the lowest average (28.6 million hours) and median (28.8 million hours) eight-week viewership totals of the past four years. Now, it’s unrealistic and unfair to expect Netflix to deliver a _KPop Demon Hunters-_sized hit every year. But it’s also not ideal to see the size of their hits shrinking over the last few summers. Let’s quickly run through some of the notable summer misses. Jennifer Lopez and Brett Goldstein’s perfectly fine romcom, Office Romance, fell off the charts after 20 million hours in its first two weeks. Top films usually last for four-plus weeks. Starry titles ideally don’t decay that fast either. Homegrown star Millie Bobby Brown couldn’t prevent the snappy Enola Holmes franchise from diminishing returns. At 14.3 million U.S. hours, the third film posted roughly half of what the first two films did in their first two weeks. What’s on Netflix calculated that per-day global views were down nearly 60% from the second movie. The Whisper Man did okay with more than 36 million hours over its first four weeks. But I expected a little more juice from a film featuring Robert De Niro, Michelle Monaghan, and Adam Scott. Kevin Hart’s Ladies First collected just 11.2 million hours total across two weeks. That’s a big miss for one of Netflix’s go-to stars. Plopping into the same bucket are Sunny Sandler’s Don’t Say Good Luck (10.3 million in two weeks) and John Cena’s Little Brother (17.5 million). Meanwhile, English-language originals Color Book (June 19), In the Hand of Dante (June 24) and Heartstopper Forever (July 17) never sniffed Nielsen’s Top 10 at all, despite needing only 2 to 5 million hours to land in the top ten most weeks. (By my count, eleven English-language scripted original films released between May and August did chart). It’s only fair to mention that Swapped (1-May) posted nearly 42 million U.S. hours over five weeks (the longest Netflix original run this summer) and is currently their eighth most-watched English-language film ever worldwide. Remarkably Bright Creatures (37 million, 4 weeks) and Voicemails for Isabelle (27 million, 4 weeks) weren’t bombs either. Still, overall, I think it’s fair to say this was a quieter summer season than we’re used to seeing from the market-leader. You might not realize that given the language commonly used in public analysis. The Twist Despite the starkly black-and-white tone of the coverage, here’s the twist: when many box office bombs arrive on streaming, their viewership looks a whole lot like many of Netflix’s supposedly successful summer releases. Hmm, where have we heard that one before? Masters of the Universe topped out at $65 million stateside against a $170 million budget_._ I’ll admit, Skeletor ripping sleeveless curls as a gym bro and bodyslamming Adam’s co-workers was funny. But, much to the chagrin of my bank account, my laughter doesn’t launch franchises. Yet the He-Man reboot opened to 19.6 million hours (from a Wednesday five-day opening instead of just one weekend), on par with Hoppers on Disney+ (19.4 million). It put up nearly 47 million hours over its first six weeks, bigger than all of Netflix’s summer releases. Pretty darn healthy and likely to land among the 25 most-watched movies on streaming this year. Sticking with Amazon, The Sheep Detectives just barely broke even at the box office with $133 million worldwide (and only $66 million domestic). I never expected cloven-hooved, cud-chewing mammals to be able to bring me to tears. Yet that’s exactly how I found myself at the end of this surprisingly affecting movie (#NoShame). It was likely the unexpected quality in a family-friendly film that powered its streaming over-performance. Sheep Detectives delivered a solid run for Prime video netting 26.2 million hours! How about franchise IP? Star Wars: The Mandalorian & Grogu had the lowest opening ($81 million) and lowest-grossing Disney-era live-action Star Wars film ($178 million domestic). One day before release, its Heat score (19.8%)—audiences who list their interest as a 7/7—fell behind blockbusters Wicked (21%), Superman (23%), Fantastic Four: First Steps (23%), Michael (23%), Toy Story 5 (26%) and Avatar: Fire and Ash (27%), according to Greenlight Analytics. The urgent enthusiasm just wasn’t there. On streaming, Mando opened to weeks of 12.1 million, 6.1 million and 2.7 million hours (21 million total) over its first three frames. Not the numbers Lucasfilm was hoping for nor the numbers of a streaming hit. But they’re in the same vicinity as some Netflix summer releases with $345 million at the global box office to offset a smidgen of the pain. Final Thoughts So why oh why does this nuance gap exist? Four key reasons: Data Literacy: A “$100 million opening” just makes sense. After decades of box office reporting, even casual movie fans are well-versed in the benchmarks of hits and home runs. There’s an immediate shorthand. But “16.5 million” hours doesn’t land nearly as cleanly. Despite leaps of progress, the streaming ratings era is still in its infancy compared to theatrical. The EntStrategyGuy and I met thanks to a late 2010s group chat of data nerds hungry to find a shred of certainty in nebulous streaming performance. I’m not surprised to see “No. 1 on Netflix” still getting misconstrued out in the wild. Timing: By Friday morning, we have the box office’s Thursday night previews totaled, allowing us to better project the weekend’s expectations. From there, ticket sales are reported daily. By Sunday, the film’s fate is usually finalized, at least in terms of public perception. In streaming, Nielsen recently improved its delay to…two weeks. The medium isn’t forced to contend with instant gratification as harshly. Financials: Theatrical film budgets are a mere Google away. Profit and loss is calculated in the cold and unforgiving naked light of day for all to see. But finding the vast majority of streaming exclusive movie budgets requires the forensic investigation skills of a Criminal Minds detective. Also, it’s very difficult to calculate how much revenue/value a straight-to-streaming films provides a streamer. This is why there are so few stories about streaming original movies “losing X amount of money”. On top of that, marketing budgets are far greater for theatrical movies than streaming exclusive movies, which leads to earlier and better awareness. This then translates to a wider pool of potential interest. Narrative Control: Netflix is the only major streaming service to publish weekly first-hand viewership data and annual engagement reports. Naturally, some headlines borrow their first-hand framing**.** Other streamers benefit from their comparative lack of transparency. They may occasionally announce vague performance platitudes such as Apple TV’s Mayday becoming its “biggest film debut on the platform to date over its first 18 days,” and that it ranked No. 1 with left-handed viewers in its first weekend. (Fine, I made up that second one). But, for the most part, they keep first-hand viewership shrouded in mystery to avoid bad press. Especially for outlets that demand multiple articles per day from their writers, it’s an easy (and understandable) way for some reporters to hit their daily article quota by just repeating what the streamers have told them. TL:DR version: Streaming-exclusive movies are asked to do different things than theatrical movies, but that doesn’t mean they should escape judgment. Both still need to draw enough eyeballs to justify their cost within the proper performance contexts. The more cleanly we can inject a little nuance into streaming analysis, the better we’ll understand the audience and content trends that drive this industry. And that’s what all of this is really about: knowing what audiences actually want! Brandon Katz is the Director of Insights & Content Strategy at Greenlight Analytics where he focuses on evaluating the ever-fluid media landscape to unearth understanding, opportunity and value. Greenlight Analytics is the entertainment intelligence consulting company redefining how Hollywood finds, understands, and activates audiences. Prior to joining Greenlight Analytics, he served as the senior entertainment industry strategist at Parrot Analytics, and as a full-time entertainment industry reporter covering the Xs and Os of Hollywood, most notably with TheWrap and the Observer.
One type of sleep linked to dramatically lower risk of dementia, Parkinson's and 81 other diseases
Greater REM sleep was linked to 80% lower Parkinson's risk and 46% lower dementia risk in a major study of over 95,000 adults tracked for years.
Henrico proposes new marijuana business regulations
Henrico County officials are considering zoning changes that would establish regulations for recreational marijuana businesses in the county as a way to implement recent changes in Virginia law governing the distribution, processing and retail sale of cannabis. The changes, outlined in a 24-page draft ordinance amendment (linked below), will
Scientists have identified a 'protein signature' in blood that could predict healthy aging
Having a certain ratio of proteins produced by immune cells in your blood is linked to a higher risk of age-related diseases, scientists report.
Official | Malian wing-back Adama Camara extends Paris FC contract
Paris FC have announced this Friday the contract extension of their right-back Adama Camara (29).Originally linked to the Parisian club until 2027, the newly promoted Malian international (one cap) ha...
Riley Children's Health announces launch of Hospital-Linked Violence Intervention Program
Is raw milk safe for kids? - CHOC
After a recent E. coli outbreak linked to raw milk cheese, here's what parents need to know about protecting their children from foodborne illness.
Six social causes recognised at Atlético’s ADN Rojiblanco gala
The Atlético de Madrid Foundation held its first ADN Rojiblanco awards gala at the Club Telefónica of the Riyadh Air Metropolitano on Wednesday 7 October, with six social projects linked to the club...
World Health Organization says Russian lab worker’s death has not been clearly linked to plague
Lions Linked to Blockbuster Jalen Ramsey Trade
ESPN insider Jeremy Fowler floated Steelers star Jalen Ramsey as a potential Detroit Lions trade target as Brad Holmes searches for secondary help.
Kobel reflects on Newcastle interest and his Borussia Dortmund future
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Pregnancy complications linked to higher risk of cardiac and renal health conditions
Women with a complication in their latest pregnancy or a previous pregnancy face an elevated risk of developing cardiometabolic-renal conditions in subsequent years, suggests a U.K. study published online ...
ConnectOne Bank joins program for lower-rate business loans in NY
ConnectOne Bank is participating in New York's Linked Deposit Program, which provides small and middle-market businesses access to lower-interest commercial loans. This initiative supports business expansion and innovation by reducing borrowing costs and improving cash flow for eligible companies across Long Island and New York State.
The Harvard Crimson (@theharvardcrimson)
83 likes, 0 comments - theharvardcrimson on October 6, 2026: "Harvard’s Faculty of Arts and Sciences is launching 25 tenure-track faculty searches, FAS Dean Hopi E. Hoekstra announced in a Monday email to faculty, further loosening a University-wide hiring freeze instituted last spring as the school draws an influx of philanthropic support. The searches, which include positions across the FAS’ three divisions and the School of Engineering and Applied Sciences, come less than a week after Hoekstra announced the school would also be upping Ph.D. admissions for the upcoming admissions cycle — and as the University continues soliciting support from donors for its academic programming. Full story linked in bio. 🖋: Abigail S. Gerstein and Amann S. Mahajan 📷: Mae T. Weir".
Scientists Just Found a Strange Link Between Cats and Happiness
Countries with more cats tended to report higher happiness, while greater exposure to a common cat parasite was linked to lower scores.
Is it possible to preserve your memories before dying? The science is moving beyond science fiction
For most of history, preserving someone’s memories after death meant relying on photographs, letters, stories and the recollections of other people. Technology is now pushing that idea much further. Scientists can record parts of brain activity linked to memory, researchers are mapping the neural networks that store experiences, and digital systems can preserve enormous amounts of a person’s voice, writing, images and personal history. That still falls far short of copying a mind. No technology
Supermassive Games suffers layoffs as more than 70 developers seem to have left the company this week
According to a LinkedIn post by Supermassive's IT and facilities director, over 70 developers have been laid off as of this week.
Scientists finally see how nature moves energy so efficiently
Researchers have captured key steps in a chemical reaction that helps nature transfer energy with remarkable efficiency. Ultrafast X-rays revealed how changes involving electrons and protons are closely linked to the rearrangement of surrounding water molecules. Because similar reactions drive photosynthesis and other energy-conversion processes, the technique could help scientists develop better catalysts, fuel cells, and flow batteries.
The Harvard Crimson (@theharvardcrimson)
24 likes, 0 comments - theharvardcrimson on October 5, 2026: "Caroline B. Kennedy ’80 introduced the Institute of Politics’ 60th anniversary forum Thursday, marking her first known public appearance at the Institute since she resigned from its Senior Advisory Committee more than six years ago. Kennedy — the daughter of President John F. Kennedy ’40, to whom the IOP is dedicated – stepped down as the committee’s honorary chair in 2020 amid concerns over the IOP’s diminished independence, declining programming, and tensions with Harvard Kennedy School leadership. Full story linked in bio. 🖋: Jen L. Phan and Mirei S. Saneyoshi 📷: Grace E. Yoon".
Childhood Housing Assistance Linked to Better Health Decades Later, Children's Mercy Study Finds
A child’s home may shape their health well into adulthood. New research led by Dr. Jeffrey D. Colvin, pediatrician, health services researcher and principal investigator at Children’s Mercy found that children who receive housing assistance are significantly less likely to develop diabetes and high blood pressure, also known as hypertension,...
Utah health dept. issues warning after 4 deaths linked to certain herbal supplements
Four deaths in Utah were tied to
Health officials issue urgent warning after four Utah deaths tied to herbal supplements
Utah health officials issued a public health warning after four deaths across the state were linked to certain herbal supplements, including kratom products and
Ninja Theory developers announce they are facing redundancy, as the studio starts laying off staff following widespread Xbox cuts
Ninja Theory staff on LinkedIn have shared either farewell messages or sombre posts on the ongoing redundancy process happening at Ninja Theory.
Research Shows These 10 Diets Are Linked to Healthier Aging
A new study found that many different diets can slow biological aging.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
TendedBar installs countertop beverage system at Clearwater entertainment center
TendedBar has installed its countertop beverage dispensing system at Launch Family Fun Center in Clearwater, Florida, according to a company LinkedIn post.