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NHS faces more challenging winter than normal, health secretary warns
Yvette Cooper has announced £140m investment in England's urgent care system, after summer heatwaves piled pressure on the NHS.
NHS faces more challenging winter than normal, health secretary warns
Yvette Cooper has announced £140m investment in England's urgent care system, after summer heatwaves piled pressure on the NHS.
Huntingdon Health and Rehab wraps up annual Fall Festival
The Fall Festival at Huntingdon Health and Rehab has wrapped up after a full afternoon of family fun.
Atrium Health's $340M behavioral health push includes north Charlotte hospital
A planned 168-bed facility near Mallard Creek will offer emergency, inpatient and outpatient care.
Fewer than 800 Scots have received weight loss jabs on NHS, BBC finds
Only five of Scotland's 14 health boards currently offer the treatment specifically for weight loss, it has emerged.
The Science of Finding Cancer Early Just Proved Itself. The ...
NHS-Galleri results fuel calls to build cancer early-detection access in communities facing the greatest environmental and healthcare disparities.
New NHS website aims to make mental health support easier
Humber Teaching NHS Foundation Trust says the site aims to make their services easier to navigate.
Science on Target: Q3 Research We Conduct
The Target ALS Global Natural History Study (GNHS) is entering a new phase of discovery. As the only international, longitudinal study generating deeply characterized clinical, genomic, and biofluid data to accelerate ALS biomarker discovery and therapeutic development, the GNHS is now beginning to deliver large scale datasets and resources needed to support new insights into […]
Utah expands healthcare AI sandbox with August AI, Nolla Health pilots, adds third-party evaluators
Utah is expanding the state's AI regulatory sandbox program with new pilots to test AI-supported prescription renewals, dermatology and physical therapy, while adding physician oversight and indepe | Utah is expanding the state's AI regulatory sandbox program with new pilots to test AI-supported prescription renewals, dermatology and physical therapy, while adding physician oversight and independent third-party evaluators to strengthen safety and accountability.
How a controversial camera system is monitoring mental health patients
The Lampard Inquiry started back in September 2024 and I remember going to the first hearing in Chelmsford. Subscribe The bereaved families made placards of their loved ones, they stood outside in silence and then laid flowers to mark the moment. Now, two years on, in a process meant to last another two years, there’s been a development. Last week, we were told the chair, Baroness Lampard, pictured below, could be looking at making interim recommendations. Throughout the process, she has remarked that although this inquiry is looking at almost 2,000 people who were under the care of Essex mental health services from 2000-2023 when they died, the findings could have national implications for other trusts. ‘Records 24 hours a day in patient’s bedroom’ So why has this happened? One system that the inquiry is going to take a closer look at is a controversial monitoring system called Oxevision. It monitors some vital signs of patients remotely by using a camera placed in a room. It’s used by 40% of NHS mental health trusts. But campaigners, particularly the group Stop Oxevision, have asked for this technology to be removed from mental health wards as soon as possible. I spoke to a member, Hat Porter, today and they described to me what they thought this technology did and explained their concerns: “It records 24 hours a day and it’s located in a patient’s bedroom, which is obviously somewhere you’d usually expect to be a private place. “Our concerns are that the use of the technology has been has been kind of implemented as a substitute for proper in-person support, that it’s kind of over relied on and that there’s a lot of misunderstandings and that the presence of a camera, which has often been used without people’s consent, sometimes without even their knowledge, that that has a really big impact on privacy, dignity and human rights.” ‘Not sufficient’ I put it to them that the company behind Oxevision would dispute their claims about consent and in videos I’ve seen online from NHS trusts, they make it clear that the technology is complementary to trained staff and not a replacement. [ ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) [ How the Nottingham inquiry shines a spotlight on other key mental health care failings ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) Victoria Macdonald · Feb 12 [ Read full story ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) A team of lawyers has been working on the inquiry and with bereaved family members who have concerns about this technology. I spoke to solicitor Priya Singh, from Hodge Jones & Allen, who made the point that questions usually asked by nurses would be missing from using devices like this. “It’s not sufficient to say, oh, the patient is moving around. Somebody must go in and say, are you okay? Are you distressed? Do you want help? Is there anything I can do? Share Channel 4 News “How are you spending your time? So I think a lot of our families cannot see the function of it when ultimately the patient should only really be observed when they’ve been prescribed to be observed, they can be observed more, but that more should really be happening face to face.” The Chair will hear evidence over the next two weeks and then a decision made after that, which could have national impact if she does decide this technology should be investigated or even removed. The Department of Health and Social Care said: “The Government is committed to ensuring that lessons are learned from the Lampard Inquiry to improve patient safety. “We are confident that the Inquiry will play an important role in identifying wider learnings for the health system following the tragic events in Essex and will contribute to improvements in patient safety.” We approached LIO Health, which runs Oxevision, for comment. Subscribe Share Channel 4 News Leave a comment
Lawrence Tech launches program to ease automakers’ reliance on rare earth materials
Lawrence Tech's Centrepolis Accelerator and USCAR are partnering to find critical material innovations to make the U.S. auto industry more competitive.
Could psychedelic therapy become NHS treatment for mental health?
Could hallucinogenic drugs become part of mainstream NHS care to treat depression?
New Hampshire Receives Over $2 Million in Federal Grants to Support Mental Health Efforts Statewide
Governor Kelly Ayotte and Commissioner Lori Weaver of the Department of Health and Human Services (DHHS) celebrated New Hampshire receiving over $2 million in federal grants aimed at expanding behavioral health crisis support and mental health services across the state. The grants will provide critical funding for New Hampshire’s 988 Lifeline and support mental health...
Game Recap: What went most wrong in Texas A&M’s loss at LSU?
KBTX senior Texas A&M sportswriter Travis L. Brown and sports director Tyler Shaw break down what went wrong and what is the Aggies most urgent fix before they face Arkansas next Saturday.
Andy Burnham proposes NHS-style social care system for England
The prime minister told the BBC that social care in England is "as unfair as American healthcare".
Burnham: 'Broken social care will in the end break the NHS'
Andy Burnham said the proposed care service would be laid out in detail and put on the ballot at the next general election.
Health board declares critical incident over 'extreme' A&E pressure
NHS Grampian say A&E and care services in Aberdeen and Elgin are under significant strain ahead of a local holiday.
Health board declares critical incident over 'extreme' A&E pressure
NHS Grampian say A&E and care services in Aberdeen and Elgin are under significant strain ahead of a local holiday.
Andy Burnham says social care is as 'unfair as American healthcare' and will break the NHS
Oracle Health rolls out AI solutions for RCM, oncology as part of broader healthcare, life sciences strategy
ORLANDO, Fla.—Healthcare is entering an AI era, and the industry needs a fundamentally different architecture designed for AI from the start, Oracle Health executives said Wednesday. | Healthcare is entering an AI era, and the industry needs a fundamentally different architecture designed for AI from the start, Oracle Health executives said Wednesday.
Youth mental health improves, New Hampshire survey reports
Youth mental health has improved since the COVID-19 pandemic, when anxiety and depression spiked for teens, according to the results of a statewide survey. The New Hampshire Department of Health and Human Services recently released the results of its 2025 Youth Risk Behavior Survey. The anonymous and voluntary survey helps measure health-related behaviors among New […]
Washington's Grant Veto Sets a Warning for British Science
A political oversight board at the NIH is a domestic American story, but its logic travels, and the NHS's own research architecture cannot assume immunity
'La Bola Negra' wins TIFF's People Choice Award, putting it on Oscar path
“La Bola Negra,” the Spanish queer epic about the intertwined lives of three gay men, won the People’s Choice Award at the Toronto International Film Festival on Sunday, confirming its status as a major Oscar contender.
Adults with severe mental illness die 15 to 20 years earlier from diseases such as cancer
Exclusive: Stark health inequalities in terms of deaths before age of 75, NHS data reveals
‘The Voice’ franchise first-ever winner found dead in lake at 43
Ben Saunders, the first winner of the original iteration of ‘The Voice’, has been found dead in a lake at 43.
May Mobility set to go public in a $1.4B deal
Ann Arbor-based autonomous vehicle technology company May Mobility is set to go public in a deal that values it at $1.4 billion.
Jaffrey couple cut energy costs with NHSaves
Evan Clements and Precia Harthcock of Jaffrey love their 1926 home, but they acknowledge the drawbacks of houses built in that era. The room that is now their sitting room, for example, was once a porch that had been enclosed and is noticeably colder than other parts of the house. The second floor was much hotter than the first floor, and their kitchen was drafty.
FBI chief Kash Patel is set to face off with Democrats critical of his leadership at Senate hearing
FBI Director Kash Patel is set to return to Capitol Hill for an oversight hearing before the Senate Judiciary Committee
Staff slept while patient killed at NHS mental health unit
Inquest hears how Rolando Torres-Pena, 22, was able to strangle and kill Hugo Flint-Cahan on a hospital ward in east London.
Sydney Sweeney faces criticism from women athletes for provocative sports betting ad
Actress Sydney Sweeney addressed public criticism regarding her provocative launch campaign for sports trading app Novig.
Native-owned Rosebud Reservation business earns national hardware industry honor
Rosebud Building Products on the Rosebud Reservation is named South Dakota’s 2026 Hardware All Star by HBSDealer for business growth and community service.
Man arrested after allegedly dismantling A/C units at Heights-area business
A 49-year-old man was arrested after a repairman reportedly caught him dismantling rooftop air conditioning units and taking copper at a Heights-area business.
Northampton mental health hospital has enough staff 'to be safe'
The removal of almost 300 patients from the Northampton site was ordered by NHS England in March.
‘Mistrust’ of Palantir may affect NHS research, says health minister
James Frith warns patients may be less willing to share data as new figures show a rise in opt-outs
Free cholesterol tests on the NHS are great – but here’s the five-point health MOT I’d really like to see
You could be walking around symptom-free and not know you’re pre-diabetic, living with hypertension or at a high risk of a heart attack, says public health academic Prof Devi Sridhar
Rising numbers of children in mental health crisis ending up in A&E
NHS emergency departments are seeing more cases of self-harm, eating disorders and emotional distress in young people.
Essex mental health trust's leaders need to improve, says CQC
It issues its latest report on an NHS trust under scrutiny at an inquiry into mental health deaths.
Scam alert: Fake online listing uses Tanner business address to steal thousands
The Better Business Bureau is warning consumers to be on high alert for a vehicle sales scam operating online and falsely claiming to be located in North Alabama.
Raquel Lee Bolleau reportedly reached settlement in 2015 with Mark Curry, who played her dad in Disney Channel movie
Raquel Lee Bolleau reportedly settled with former movie dad Mark Curry years before suing Disney on negligence in relation to alleged on-set sexual abuse.
Apple Maps Ads Are Here, and There's No Way to Turn Them Off
Ads in Apple Maps are live in the United States and Canada, which means iPhone and iPad users will see them when searching for locations and when viewing Suggested Places. Apple announced plans to bring ads to the Maps app in March, and said the feature would roll out starting in late summer. Apple confirmed to 9to5Mac that ads began showing up for users over the last few days, with ad placement to ramp up in the coming weeks.
'It's a bit odd at first': The robot helping with NHS health checks
A Dundee GP has trialled a robot that takes patients through health checks to save the doctor's time.
Boyle Heights community clinic says hundreds of residents treated for "toxic exposure" after Lineage fire
Some of the most common diagnoses among Boyle Heights patients included the toxic effects of smoke, contact/exposure to hazardous substances and acute upper respiratory infection.
Willerby Hill mental health unit could replace ageing Hull sites
NHS says a purpose-built facility at Willerby Hill will offer a "modern, therapeutic environment".
‘We’re seeing lots of people who feel dizzy’: how heatwaves are taking a toll on people’s health and the NHS
Doctors and nurses describe rise in fall injuries and other heat-related problems on top of stifling working conditions
Risk of patient safety 'bonfire' with Health Bill changes, Lib Dems say
The party says the government's plans to modernise the NHS risk another major hospital scandal.
Full body MOTs - the future of healthcare or a headache for the NHS?
The private body scan industry is booming, but is it doing more harm than good?
Steppin’ Out Festival in Blacksburg draws small business vendors from across the region
Vendors at Blacksburg's 45th annual Steppin' Out Festival say the weekend event is more than a sales opportunity — for some small business owners, it's their only storefront.
NHS must plan for heatwaves like it does for winter, health secretary says
The warning comes after the NHS sees a surge in patients and problems with equipment in high temperatures.
Indian Health Service Honors Choctaw Nation Associates for Outstanding Work
CNHSA associates received numerous honors for excellence in healthcare service.
Voices In Science Lecture Aug. 13: Learn About New Mexico 250 Years Ago By State Historian Rob Martínez
NMDCA News: As the United States celebrates its 250th anniversary, the New Mexico Museum of Natural History & Science (NMMNHS) is thrilled to welcome State Historian of New Mexico Rob Martínez for a lecture discussing what the Land of Enchantment looked like in 1776. Voices in Science: New Mexico 1776. Celebrate our nation’s 250th anniversary […]
With bombing campaign unlikely to change Iran’s posture according to US intel, Trump faces limited options
Two weeks into a renewed bombing campaign against Iran, with US forces taking casualties and allies wary of the conflict escalating further, President Donald Trump insists that Iran is “desperate” to find an end to wave after wave of US attacks.
Te Whatu Ora taps NHS partner for AI development
AI director Sonny Taite says initial work with UCLPartners affirms its AI scribe rollout across emergency departments.
Sussex Partnership NHS trust joins scheme to tackle racism
The new pilot aims to strengthen support for "racially marginalised" carers in mental health services.
Women's pain normalised in NHS, Cardiff health summit told
An operation left Donna Davies in constant pain but she only felt believed when her husband spoke up.
Mensah Explains Shocking Duke Exit: 'Business Is Business'
Darian Mensah publicly spoke on his dramatic transfer from Duke.
Back to school at 26: Former UNC two-sport commit returns to college football
Jordyn Adams chose pro baseball over college football in 2018. Eight years later, the former Green Hope High School standout is headed back to school.
We are living fewer years in good health: Is the NHS part of the problem?
What is driving the UK's fall in healthy life expectancy?
Scientists discover new blood group, resolving a 50 year medical mystery - Futura-Sciences
Decades of searching for a single molecule Scientists named the missing molecule from the 1972 sample the AnWj antigen. For fifty years, hematologists tried and failed to find the genetic blueprint responsible for it. A research team at NHS Blood and Transplant and the University of Bristol finally found the...
Burnham urged to ditch ‘dangerous’ UK-US NHS drug deal
Exclusive: health groups call on expected next prime minister to rip up agreement, which analysis suggests could lead to 229,000 excess deaths by 2036
iPhone Air 2 Could Get an 11% Battery Capacity Boost
Apple is reportedly working on a second-generation iPhone Air that's expected to launch in spring 2027, and one of Apple's main aims is to improve battery life. We now have the first rumor suggesting what kind of improvement could be coming. In a post on Weibo listing supply chain predictions, serial leaker Digital Chat Station said the iPhone Air 2 is expected to feature a 3,500mAh battery.
NHS trust to spend £30m on Lampard mental health care inquiry
The inquiry is looking into more than 2,000 mental health-related deaths over a 24-year period.
NHS app to use AI to determine which service best for patients
The update will be available to all users in England by April 2028, the health service says.
Digital diabetes tool shown to improve patient care and cut health care costs
A new study by University of Manchester researchers has linked a digital platform helping people manage type 2 diabetes to better blood sugar control, improved health and potential long-term NHS cost ...
NHS to reward people who walk 30 minutes a day
The "marathon a month" scheme, developed with former Olympic medallist Sir Brendan Foster, will launch early next year.
NHS to take over troubled Northampton mental health hospital
The removal of almost 300 patients from the Northampton site was ordered by NHS England in March.
Women with PMOS should have yearly NHS checks, says health watchdog
Despite affecting millions of women in the UK, PMOS is still under-diagnosed and inconsistently managed, say experts.
Women with irregular periods should be checked for PMOS, NHS says
Polyendocrine metabolic ovarian syndrome is underdiagnosed and inconsistenly managed, according to Nice
Former NFL star Warrick Dunn hosts wellness day with health screenings, financial education
Saturday’s event was centered around improving physical health, financial stability, and mental well-being.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
How a New York race became the first front in the AI industry’s midterm war
Competing AI interests poured millions into the Democratic primary, a taste of more spending to come this fall and elections beyond.
ICO watchdog opens inquiry into cameras in mental health patients’ bedrooms
Exclusive: Oxevision system used by 40% of NHS mental health trusts being scrutinised by information commissioner over privacy concerns
Georgia runoffs 2026: Rick Jackson topples Burt Jones, wins GOP nod for governor
The billionaire healthcare executive won despite President Donald Trump and Gov. Brian Kemp endorsing his opponent.
BioSTL Builds Gateway for U.K.'s National Health Service Innovators with St. Louis as Launch Point into U.S. Market
BioSTL Global, the international arm of BioSTL, the backbone of the region's bio-innovation ecosystem, has reached an agreement with the innovation network commissioned by the U.K.'s National Health Service (NHS) that promises to attract new companies to St. Louis' nationally recognized healthcare industry.
Health services merger plans laid out
The creation of one NHS trust will ensure money is spent more efficiently, according to the proposal.
NHS staff battling wave of food supplement disinformation
Exclusive: Cancer charity says dispelling falsehoods gleaned from social media is now routine task for clinicians
‘Hands Off Our NHS’: Anti-Palantir Protests Break Out in UK Over Deal With National Health Service
Crowding the gates of a major health care conference, protesters called for Palantir to be booted out of the UK’s National Health Service over privacy concerns and political grievances.
NHS single patient record to be debated for first time
Reforms to the NHS records system could result in 20,000 fewer visits to A&E annually, according to government projections.
Giants news: Francis Mauigoa signs his rookie contract
Sisi Mauigoa has officially signed his rookie contract
London NHS trust rolls out animal therapy for mental health
Katia Stanford takes Ruby on to hospital sites to work with people with various mental health needs.
Teenage patients 'ignored' before fatal NHS trust failures
Mental health patients say nobody listened to their concerns about a north-east England trust.
South West heat health alert as holiday temperatures near 29C
A yellow heat health alert is issued with warnings of NHS pressure, coastal risks and a heatwave.
Health chief warns of high child poverty rates in NHS Highland area
Public health director Jennifer Davies says of the 12,834 under-fives in the area, almost 22% lived in relative poverty.
Seattle Mariners to Promote Top Prospect Colt Emerson
The top minor leaguer in the Mariners organization will join the team ahead of a series finale against the San Diego Padres.
Chartbook 449: Voldemort on Threadneedle street. The Bank of England and the "haunted house" of English politics.
Imagine the scene: In some Harry Potter version of 21st-century London, a group of deathless UK Treasury officials gathered from across the last century huddle over warm pints and glasses of Chardonnay. Around the table there are officials from the 1920s, the 1930s, the 1970s, 2022 and today. Inevitably, in May 2026, the subject of conversation is the disintegration of the current Labour government. Despite its huge majority in parliament, it has been reduced to tatters by catastrophic local election result. These exposed the fact that rather than having a government with a clear popular majority, the UK is like most other modern societies divided into 5 segments each of which commands between 26 and 16 percent of the vote. Perhaps unsurprisingly, the leadership at Nos 10 and 11 Downing Street - where the Prime Minister and the Chancellor (Treasury Secretary) work - seem paralyzed. They are caught between mounting discontent over unfairness and the cost of living, and tough fiscal strictures that push them into making unpopular spending decisions. In the London pub, the Treasury officials from across the ages, can barely hide their satisfaction at the latest display of democratic politics caught in the vice-grip of financial logic. “Remember the mur d’argent and the banker’s ramp?” “Just like yesterday!” There are smirks around the table. Then the representative of 2026 pipes up: “One thing you have to say about the current lot (referring to the latest hapless Labour government), you don’t have to teach them about the bond market!” There is a murmur of ascent from the Treasury Mandarins. The trauma of the fiscal crisis of September-October 2022 sits deep. Back then, in the final stages of Tory decay, a ‘mini budget’ that challenged fiscal orthodoxy led to a brief but fierce panic in one of the oldest government bond markets in the world (aka gilt market). Now all you have to do is to mention the “bond market” to hush debate. [ Paul Mason@paulmasonnews In the name of public service, and as ex-economics editor of BBC Newsnight, I offer to do a zoom call, tonight, with any Labour MP who wants to understand why bond markets do not "fall into line" with governments. 1/ 3:57 PM · May 12, 2026 · 466K Views 224 Replies · 674 Reposts · 3.93K Likes ](https://x.com/paulmasonnews/status/2054229532404519082?s=20) “And the funny thing is”, the young man in the huddle continues, “they don’t even want to talk about … ”. There is a sudden hush. Significant looks are exchanged around the table. About? One of the senior figures puts down his glass with a decisive “clink”. He-Who-Must-Not-Be-Named has entered their thoughts. Meanwhile, a few miles away in a grubby pub in Bloomsbury, two conspirators from the camp of Critical Macrofinance huddle over cans of low-alcohol IPA. They look at each other and blurt out loud: “The Bank!” “Everyone in the bloody Labour party is talking about the bond market. But why aren’t they even mentioning … the Bank of England!?” “Why is no one talking about Voldemort?” In Paul Mason’s blogpost, after much chest-thumping about basic fiscal logic, the basic point about the Bank of England is buried in the fine print at #3 in his list of suggestions as to what a radical Labour government might actually be able to do! [ Conflict & Democracy Down with the bond market! Down with gravity! It may seem unfair to focus on Labour MP Paula Barker for her off-the-cuff assertion that the bond market would have to “fall in line” with Andy Burnham, should he replace Keir Starmer as prime minister. But Burnham himself told the New Statesman that Labour had to “get beyond this thing of being in hock to the bond markets… Read more 2 days ago · 100 likes · 3 comments · Paul Mason ](https://htsf.substack.com/p/down-with-the-bond-market-down-with?utm_source=substack&utm_campaign=post_embed&utm_medium=web) Back in Bloomsbury they shake their heads and ask: “Didn’t we learn anything from the Eurozone crisis?” Meanwhile, as if summoned to the conversation by some higher force, the “pink pages” announce: “The days of ultra-cheap government borrowing have come to an end” and Martin “Whizzard” Wolf publishes the graph of the season Look at the UK in 2026, perilously positioned on the upper edge of the pack. No wonder no one in London needs any lessons about the “bond market”. But, look again. Imagine how they feel in Rome. What is London’s nightmare in 2026? The nightmare is that you end up like Italy in the early 2010s during the Eurozone crisis. Once comfortably situated in the middle of the pack, watching with horror as your ten-year yields explode to 7 percent and “spreads” become a national nightmare. One of the largest economies in Europe, a founding member of the euro, stigmatized. But the message of the Italian experience is ambiguous. After all, the stigma didn’t last. In 2026, Italy borrows at rates lower not only than the UK but the US. The US, which, as everyone knows, enjoys the “exorbitant privilege” of being the issuer of reserve, safe asets. What kind of magic is this? How did Italy, in the space of fifteen years, go from being good, to bad and back again? Which brings us back to our dissident friends in their Bloombury boozer and their memories of the Eurozone crisis. Italy never was Britain - with its ongoing fiscal deficits. Without interest payments, on primary balance, from 2000 to 2020 Italy ran a tight fiscal ship. Even in 2008 it barely went into deficit and when it was being put on the rack in the early 20210s its primary surplus matched that of austere Germany. So, what happened? How did it end up stigmatized? Of course Italian politics didn’t help. Berlusconi was at the helm and he had legal issues. But amongst friends in the Bloomsbury pub, Berlusconi is a sideshow, the name we whisper to each other is “Trichet”. From 2004 to 2011 the ECB was headed by Jean-Claude Trichet, ex of the French Treasury, more German than the Germans. After 2009 as the news of the Greek fiscal disaster broke, the European bond markets wento into panic mode and Trichet began a brutal game of cat and mouse. Between 2009 and 2011, Trichet intervened in the bond market to help, only when he thought he had compliance with austerity. When he thought they were uncooperative, he withdrew. In the summer of 2011, he even made direct suggestions to his Italian counterparts in Rome, as to how Italy should be governed. It was this cat and mouse game that drove the bond markets crazy and exposed Italy to a violent squeeze. When Mario Draghi took over the ECB at the end of 2011 and declared “whatever it takes”, the pressure on Italy, gradually eased. It is that starring role that has made Draghi into the towering figure in European politics that he remains today. So now you see why voices in London hush when it comes to the Bank of England. “The bond market” isn’t an irresistible objective force like the weather or an avalanche. It can appear like that. But that depends on the way it is being handled, or not handled by the central bank. Which is why the silence about the Bank of England in London right now is so significant. If you think this all sounds a bit fishy, coming from a left-liberal Keynesian like myself, well, let me introduce you to Robin Brooks, who, to put it mildly, plays on a different quidditch team to me. Here, from the position of a fiscal hawk is Robin’s celebratory account of the Bank of England’s role since 2022; In October 2022, at the height of the bond market blow-up in the UK, something incredible happened. Governor Andrew Bailey told British pension funds the Bank of England would end its support program for the country’s fragile gilt market, drawing a line under how much help the central bank was willing to give to exposed pension funds and - implicitly - the government. By the end of that week, Kwasi Kwarteng - the finance minister - had resigned. Prime Minister Liz Truss would soon follow. This episode is so incredible because it contrasts with what happened in the Euro zone earlier that year. Bond markets in Spain and Italy were under pressure amid high inflation and rising interest rates. In the middle of this, Mario Draghi - Italy’s Prime Minister - resigned, compounding pressure on bond markets of high-debt countries on the Euro periphery. Unlike the Bank of England, the ECB caved. It bought Italian and Spanish government bonds in an effort to cap yields and introduced a new tool that signaled to markets it might do such caps more frequently going forward. Faced with pressure on bond markets, the ECB capitulated to political pressure from high-debt countries like Italy and Spain. The Bank of England stood its ground and toppled the Truss government. This kind of thing has long-lasting consequences. It means markets price a higher probability of yield caps in the Euro zone, which keeps Italian and Spanish yields artificially low, while markets feel free to push up UK yields without fear of central bank intervention. As I flagged in yesterday’s post, this means you really can’t compare UK yields to those of other high-debt countries. The UK looks worse, but only because its central bank isn’t interfering with markets. There’s more to this than just that 2022 episode. The Bank of England has also been much more aggressive in its quantitative tightening (QT) than other central banks. If one motivation for quantitative easing (QE) is to lower bond yields - especially longer-dated ones - then it stands to reason QT pushes yields up. The left chart above shows a four-quarter moving average of UK government debt issuance (black line) in percent of GDP and which sectors absorb this issuance, including the Bank of England (blue bars). The right chart above compares the Bank of England’s accumulation or run-off of government bonds (blue line) with that of other central banks, where this blue line is the same as the blue bars in the left chart. The Bank of England was quicker and more aggressive than other central banks in downsizing its bond holdings, so UK yields will have risen more than elsewhere also for this reason, not just because of Governor Andrew Bailey’s remarks in October 2022. Back in October 2025, after a conversation in New York with friends in British politics, my sense of dysphoria was such that I raised the issue of the Bank of England openly in the FT Since 2008, the UK has slid into a deep economic and political predicament. Growth has stagnated to a degree far worse even than in the 1970s. The Tory leadership’s wager on the Brexit referendum spectacularly backfired, leaving the UK isolated from Europe and at the mercy of its special relationship with the US, many of whose political class regard the UK as a basket case. After years of austerity, the Labour party lurched to the left and then back to the centre. The Tory party has been eclipsed by the populist nationalism of Reform. Any British government should be worrying first and foremost about how to restart growth. Instead, Keir Starmer is beset by shades of the gilt market panic triggered by the Liz Truss government in 2022. The debt level is higher than in recent years, but there is no cause for panic. UK debt is at far from critical levels and of long duration. Whether you want to “take back control” or launch progressive economic policy, a democracy dogged by fear of bond market vigilantes is unhealthy. In a country that is a monetary sovereign, this climate points to one thing: a disconnect between the government and the central bank. Since 1997, the independence of the Bank of England has become a sacred cow. But independence is what you make of it. And in the wake of the gilt market crisis of September 2022, relations between the Bank of England and the UK government need a reset. In normal times, there is no doubt that an inflation-targeting independent central bank can serve a country well. But since 2008, the UK and other advanced economies have not had the luxury of such simple problems. To their credit, central bankers around the world have not stood on orthodoxy. After 2008, the US Federal Reserve rescued the global banking system and, through quantitative easing, it stabilised the Treasury market in the face of huge deficits. In Europe, things were trickier. Both the Bank of England under Mervyn King and Jean-Claude Trichet’s European Central Bank played cat and mouse with national governments. This was a high stakes wager that between 2010 and 2012 escalated bond market tension and triggered a disastrous turn to austerity. Shaken by the impact of those shocks, their successors, Mark Carney and Mario Draghi adopted a more protective stance (assuming you were not the government of Greece). Recall that Draghi’s legendary slogan, “Whatever it takes”, was uttered to face down the City of London’s bond vigilantes. In 2015, Draghi launched QE — financial repression by another name. In 2016, Carney used the authority of the Bank of England to stabilise markets following the vote for Brexit, an exemplary demonstration of how central banks can underpin democratic choice, even when those choices are wrong headed. All these were independent central bankers steeped in the best practice of the 1990s, who recognised that historic crises demanded radical action. It was the price surge of 2021-2023 that poisoned the atmosphere. Though the shock came mainly from the supply side, central banks ended up in the dock. Nowhere more so than in the UK. The Bank of England reacted with aggressive normalisation. Faced with a cost of living crisis, the governor called for workers to accept real wage cuts. In early 2022, as gas prices were at record levels and Russia’s army was poised to invade Ukraine, the Bank adopted a stringent programme of quantitative tightening, elevating interest rates. When the Truss government got itself in trouble, the Bank took almost a week to come to the rescue. Rather than enacting a charade of normality, it is time to recognise that in 2025 the UK faces a period of historic transition. To meet this challenge, what is needed is a new concordat with the Bank. This should not ignore inflationary pressures or the long-run trajectory of debt, but should affirm the priority of reviving investment-led growth. One could follow Donald Trump in demanding interest rate cuts. The Bank could shadow the ECB in its commitment to capping Eurozone yields. But the top priority should be to lay the ghost of September 2022. The Bank’s slowing of QT last month was a concession. An immediate and complete end would send the right signal. Such a concordat will not by itself restore sanity to politics, solve the housing problem or rebuild the NHS. But it would help to lift the fear of bond market crisis, which is paralysing the effort by democratic politicians to answer the fundamental questions facing the nation. Now, that call for a new concordat between government and Bank of Englands seems more urgent than ever. The problem is that in October 2025, Starmer still had some authority. Today the government is in tatters. And when you are the “under the harrow” - to echo a phrase of Montagu Norman’s from the 1920s - it is the worst possible time to consider institutional change. To make general arguments at a time of crisis can only seem like special pleading rather than a general argument for long-term change. The same, unfortunately, is also true for the other basic institutional reform that Britain urgently needs i.e. the abolition of the out-dated first past the post electoral system and its replacement by a moderated form of proportional representation. And thirdly - whilst we are saying the quiet parts out loud - Britain needs to reopen the question of EU membership. What the local election results of 2026 show is that this remains a key issue. And what they also show is that there is a clear majority that would favor a return. Until these basic features of Britain’s political economy are addressed the country will carry on its politics as though in a haunted house, governed by governments that lack actual majorities, conjuring up false constraints whilst ignoring the real ones. This one is for DG and MI. I love writing the newsletter. If you enjoy it too and fancy buying me a coffee once a month, you know what to do. Click below! Subscribe
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