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OPD: Package found at business not suspicious
Authorities responded Thursday afternoon to a report of suspicious package at an Omaha business.
Paid training program helping to fill Rutland healthcare worker gaps
A new paid training program in Rutland is helping people become medical assistants while addressing the region’s shortage of entry-level healthcare workers.
‘Topdog/Underdog’ revival opens Steppenwolf's 51st season
When I reviewed the Chicago premiere of “Topdog/Underdog” at Steppenwolf Theater in 2003, I suggested that Suzan-Lori Parks' play about the rivalry between two Black brothers didn't deserve its 2002
Friendswood ISD approves science lab designs for 2 campuses
The Friendswood ISD board approved preliminary science lab designs for Windsong Elementary School and Bales Intermediate School for the 2027-28 school year.
UMKC’s massive new health sciences building promises to transform how Kansas City trains dentists—and how thousands of patients receive dental care
UMKC’s new health sciences building promises to transform how Kansas City trains dentists—and how thousands of patients receive dental care.
UMKC’s massive new health sciences building promises to transform how Kansas City trains dentists—and how thousands of patients receive dental care
UMKC’s new health sciences building promises to transform how Kansas City trains dentists—and how thousands of patients receive dental care.
‘What happens inside these walls matters’: Hinds Community College leaders mark opening of new Health Sciences Complex
The college broke ground on the project two years ago.
Swarthmore bakery Pastry Pants has closed amid rising costs and waning business
Owner Robert Smythe said a constellation of factors pushed him to shut down the bakery, formerly located at 10 Park Ave. in downtown Swarthmore.
Georgia governor debate: Bottoms, Jackson clash over health care, data centers
Democrat Keisha Lance Bottoms and Republican Rick Jackson faced off Tuesday night in Doraville for their only televised debate.
2 federally charged after kratom seized at Oxford, MS business
MEMPHIS, Tenn. — Two men accused of possessing kratom and illegal substances at an Oxford, Mississippi, business have been federally charged Thursday. Yahya Mohamed Mosleh, 51, and Islam Moha…
Suspect wanted for burglary, NOPD says
NOPD look for man suspected of business burglary in 600 block of Loyola Avenue
'Forgotten Island' review: DreamWorks delivers an epic adventure for weirdos
Plus, Dave Franco in the oddball role he was born to play.
New poll reveals which political party has a 5-point advantage ahead of November elections
Democrats hold a 5-point advantage over Republicans with just over a month to go before the midterm elections
ACCESS update: CMS boosts coverage for heart failure technologies
The ACCESS model is designed help more patients get treated and managed with advanced technologies. In addition to heart failure, improved coverage has been announced for Medicare beneficiaries battling COPD, substance use disorders and nicotine dependence.
US Department of Labor investigating Rochester businesses
The Minnesota Department of Labor confirmed the U.S. Department of Labor is investigating numerous Rochester businesses.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
When pollution becomes personal: Southwest Louisiana nonprofit hosts Health and Environment summit
Cancer. Heart disease. COPD. A Southwest Louisiana nonprofit says almost every family in the area has been touched by one of them and organizers believe pollution is to blame.
Commercial AI cuts pulmonary nodule assessment times by up to 25%
The use of artificial intelligence-enabled software could significantly reduce interpretation times for chest CT scans, experts write in RSNA's Radiology.
Allegheny Health Network launches clinic for advanced COPD patients
Based at AHN Allegheny General Hospital and the Breathing Disorders Center at the AHN McCandless Outpatient Center, the clinic has been operating for about two months.
Healthcare was built around specialties. Patients experience it as one journey.
Care coordination starts by designing healthcare around people, not disconnected systems.
COPD: Prioritizing Lung Health in Aging
Don't overlook your lungs. As we age, the risk of COPD increases. Learn the signs and why lung health must be part of the healthy aging conversation.
LSU New Orleans hires ex-NOPD chief; PR vet launches own firm; new staff at education nonprofit
Take a look at some of the recent promotions and new hires announced at south Louisiana businesses.
MAHA Political Endorsements Shape August Republican Primaries
MAHA political endorsements target state Republican primary elections with medical freedom legislation. Analysis of Kennedy's health policy impact on 2026 races.
Sanofi suspends chronic lung disease phase 2 study, tied to ‘strategic business reasons’
Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce Biotech has learned. The trial, which began only back in April, was a randomized, double-blind, placebo-controlled study to measure the reduction in mucus plug score following treatment with SAR445399 compared with placebo in adults aged 18 to 80 years with NCFB, a chronic lung disease. The trial was officially reported as halted on July 29, the day before Sanofi’s second-quarter earnings call. The decision to pause the trial was made “as part of a company-wide portfolio review for strategic business reasons,” and not due to safety concerns, a Sanofi spokesperson told Fierce. The move to pause the NCFB trial comes during a trying time for Sanofi following a year filled with a series of trial fails. In February, the French pharma ousted CEO Paul Hudson and appointed Merck KGaA leader Belén Garijo, M.D., Ph.D., to steer the ship. Since then, Garijo has been doing a deep dive on correcting the company’s strewn R&D and clinical strategies. On July 24, Sanofi scrapped amlitelimab for atopic dermatitis, despite its lore as being a potential $5 billion blockbuster. During its second-quarter report, the company abandoned two more assets, balinatunfib and itepekimab, following failed trial results in psoriasis and chronic obstructive pulmonary disease, respectively. SAR445399, only first revealed by Sanofi in 2023, is an anti-interleukin-1 receptor 3 monoclonal antibody developed to block the interleukin 1, 33, and 36 cytokine pathways. These pathways can be important in chronic immune-related dermatologic diseases, such as atopic dermatitis and hidradenitis suppurativa, as well as respiratory conditions, such as NCFB. Related Sanofi’s new CEO ‘looking deeply’ at late-stage pipeline as clinical clearout continues NCFB affects roughly half a million people in the U.S., with a global incidence of greater than one million cases. In August 2025, Insmed received FDA approval for Brinsupri, a DPP1 inhibitor targeting neutrophil activation, for treatment of NCFB in adults and kids ages 12 and older. The British biotech Infex Therapeutics showed promising NCFB phase 2a data using their monoclonal antibody, INFEX702, which acts by disabling Pseudomonas aeruginosa, a bacteria known to be a major pathogen of NCFB. Sanofi is currently running a separate phase 2 study testing SAR445399 as a potential treatment for the inflammatory skin condition hidradenitis suppurativa.
Gov. Bill Lee
It was an honor to join business & community leaders with the Rotary Club of Nashville today to highlight our city & state’s bright future.
Pollen may exacerbate COPD symptoms | Harvard T.H. Chan School of Public Health
Pollen exposure can further reduce lung function in people with chronic obstructive pulmonary disease, according to a new Harvard Chan School study.
Health department temporarily closes Henry’s Restaurant in downtown Fort Wayne
The Allen County Department of Health has temporarily ordered Henry’s Restaurant to close following a recent inspection.
Most points by a 1st overall pick in their summer …
Most points by a 1st overall pick in their summer …
DEVELOPING: Roanoke PD says it’s investigating Roanoke dog daycare business
In a social media post on Sunday, July 5, 2026, the agency announced an active investigation was being conducted.
Fourth of July fireworks pose hidden health risk for certain Americans, experts warn
Americans release 300 million pounds of fireworks annually, creating smoke that worsens asthma and COPD, experts warn.
Appalachian State strikes again on trolling Michigan football program
It's the gift that keeps on giving. Appalachian State trolled the Michigan football program once again for the loss in 2007.
Iraq detains politicians, officials in anti-corruption crackdown
Iraqi security forces arrested politicians and senior officials early on Sunday as part of a broader anti-corruption campaign ordered by Prime Minister Ali al‑Zaidi, a government spokesperson said.
Trump insists U.S. will not invest money in Iran as part of peace deal
Others in the president's circles, including Vice President JD Vance, have suggested Tehran could gain access to a major investment fund if it upholds its side of the peace accord.
Rutgers Women’s Basketball Conference Home and Away Opponents Revealed
Earlier today, the Big Ten announced the confirmed conference matchups for the 2026-2027 Big Ten women’s basketball season. As a result, we now know which teams Rutgers will play at home and which teams they will play on the road. That list is as follows: Home: Illinois, Michigan State, Nebraska, Northwestern, Ohio State, Purdue, UCLA, […]
This AI-Powered PDF Editor Gives Business Owners a Smarter Way to Work
Skip the subscription and get lifetime access to a full PDF suite for $50.
Omaha Police discuss increase in mental health calls, shots fired on officers
After seven officer involved shooting in the metro in the past eight months, OPD's crisis negotiators share how they are working to prevent and de-escalate a growing number of calls.
CCC and AT&T Partner to Bridge Divide
Coahoma Community College collaborated with AT&T Mississippi and Digitunity on Wednesday, April 29, to distribute free laptops to students and residents during a launch event at Safe House on CCC’s campus, working to close the regional digital divide. The distribution program targets technology gaps across the college’s five-county service area, which includes Bolivar, Coahoma, Quitman, […]
An iconic CT business draws customers from across the state. It’s called tastier than ‘the ballpark’
‘It feels amazing to run a business that has been a tradition for many families to eat at,” said the owner, who was also once a customer.
Craig Morton, longtime Cowboys and Broncos QB, dies at 83
Craig Morton spent 18 seasons in the NFL, and led the Broncos to their first ever playoff appearance and Super Bowl.
MGM Resorts' quarterly profit misses estimates amid slower Las Vegas business
MGM Resorts International missed Wall Street expectations for first-quarter profit on Thursday, hurt by weaker performance of its Las Vegas businesses amid ongoing macroeconomic uncertainty.
Dodgers on Deck: Monday, April 27 vs. Marlins
The Dodgers continue their homestand by welcoming the Miami Marlins to town beginning Monday night at Dodger Stadium in Los Angeles. Yoshinobu Yamamoto has five quality starts in five tries this season, with a 2.48 ERA and 3.63 xERA, but only has two wins, thanks to getting exactly one run of support in three of […]
Donte DiVincenzo becomes 4th player with No. 0 jersey to tear his Achilles in the past year
Brown: In northern Minn., junk speaks to emotional divide in politics
"Keeping the neighborhood clean is a shared value, especially in town, but rural attitudes about inoperable vehicles vary considerably," columnist Aaron Brown writes.
Building a massive dam between Alaska and Russia could prevent AMOC collapse, scientists say
Building a dam in the Bering Strait might preserve the Atlantic Meridional Overturning Circulation, but experts warn it could also threaten wildlife, Indigenous people and shipping — and could actually speed up its demise.
Alstom sheds third of its value after train maker pulls cash flow target
Alstom shares fell more than 33% when they opened with an around 15 minute delay on Friday, after the French train maker pulled its three-year cash flow forecast the night before.
Panthers tap Atrium Health for practice facility
The project ties into a broader $800 million stadium renovation and new venues reshaping Uptown.
NOPD investigating after 3 Uptown businesses broken into, burglarized over the weekend
The businesses shared photos of the damage over the weekend.
Business owners react after Uptown burglaries as NOPD searches for suspect
Police said the same suspect is believed to be responsible for all three break-ins, which happened early Sunday morning.
Can the US afford guns and day care?
Trump intends to cut social program spending in favor of funding his war
GMB Management Software for Multi Location Business
GBPPromote GBPPromote Indore, Madhya Pradesh, April 05, 2026 (GLOBE NEWSWIRE) -- GBPPromote, a fast-growing Google Business Profile (GBP) management software, is gaining strong traction among agencies, franchises, enterprises, and individual businesses looking for a simpler and more scalable way to manage their local presence on Google. Adopted widely by franchises, agencies, and enterprise teams for multi-location GMB management, the platform is built to handle the kind of operational work that
Avi-Go Launches Avi-Go.AI, Building the Intelligence Layer for Business Aviation
Discover Avi-Go.AI, Avi-Go’s upcoming AI-native platform for smarter business aviation intelligence, analysis, and workflow automation. Avi-Go.AI represents a fundamental shift in how intelligence is accessed and applied in business aviation” — Colin, CEO & Founder of Avi-Go. SINGAPORE, April 2, 2026 /EINPresswire.com/ — In business aviation, competitive advantage is no longer defined only by access […]
NOPD seeks suspect in $1,000 theft from Carrollton Avenue business
Police say man reached behind counter, took cash from register before fleeing on bicycle
'Unbelievable' Stretton goal 'one of best' at Truro
Jack Stretton's goal in Truro City's 1-1 draw with Solihull Moors is described as one of the best at the club's new ground.
Only 4 Louisiana parishes fall below the U.S. average for adults with COPD. See the data.
Chronic obstructive pulmonary disease, or COPD, is the 5th-leading cause of death in the United States and the cause of more than 150,000 deaths each year. Here's the data for each Louisiana parish.
March Madness First Four: Live updates, scores for Howard vs. UMBC, Texas vs. NC State as NCAA tournament begins
Rick Perry says his political group will spend “whatever we need” to support John Cornyn in Senate primary
The former Texas governor chairs the Lone Star Freedom Project, a group that has already spent almost $18 million boosting Cornyn against Attorney General Ken Paxton and Rep. Wesley Hunt.
291 Dartmouth Health doctors ranked among New Hampshire’s best for 2026
Total of 291 Dartmouth Health doctors named to the list
GOP businessman Rinke rules out run for governor, noting state party struggles
The Bloomfield Township businessman said he researched his chances but has doubts about the Republican Party’s ability to unite around a candidate.
'Kpop Demon Hunters' earn first K-pop Grammy
An impressive 86 Grammys will be handed out pre-broadcast
'Kpop Demon Hunters' earn first K-pop Grammy
An impressive 86 Grammys will be handed out pre-broadcast
The biggest accelerant of our political tribalism
In years past, my go-to word in describing our political condition was “polarization.” I used it endlessly and still do on occasion. But as time has moved on, and the divide has only grown in depth and toxicity, polarization no longer seems to fully capture the magnitude of what has overtaken us. In its place, […]
Exploring health consequences of Asthma-COPD overlap syndrome in a national study
Scientific Reports - Exploring health consequences of Asthma-COPD overlap syndrome in a national study
Buffalo Bills at Jacksonville Jaguars: game chat
The Bills and the Jaguars meet for the third time in franchise history in a Wild Card game.
I Grew Up on Atari—Now I'm Reliving It on Gamestation Go in 2025
Commentary: Wander down Gen X gamer memory lane with 200 games, including Pac-Man, Asteroids, Berserk and Centipede.
Body cam captures LOPD officer making false claims about business owner months before owner’s arrest
A simmering dispute between a Live Oak businessman and the city’s police department continues to escalate. Newly released body-worn camera footage showed a Live Oak police officer who made a series of false and inflammatory claims about the man and his business.