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AI facial health recognition tools help physicians assess age and survival risk to guide personalized treatment
Mass General Brigham researchers trained a new AI foundation model on more than 40 million facial images, and used it to develop AI tools to estimate biological age and directly predict survival risk in patients with cancer
INOVIO Announces Favorable Judgment in Litigation with VGXI, Inc. and GeneOne Life Science
/PRNewswire/ -- INOVIO Pharmaceuticals, Inc. (Nasdaq: INO), a biotechnology company focused on developing and commercializing DNA medicines to help treat and...
Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)
As IGN Retreats From Podcasts, Fired Hosts Start Their Own
X Button is the newest independent gaming network
Scary Business Trick or Treat set for Sunday in Crestline
CRESTLINE – The Crestline Community Development Team (CCDT) is hosting Scary Business Trick or Treat from 4 to 5 p.m. Sunday, Oct. 25 in downtown Crestline. The costume contest will take place at 5:15 p.m. on the patio at The Hub. Contest age groups are 0-2, 3-5, 6-10, 11-13, and family/group. “Downtown is always full […]
‘Keep away from the doctor’: a visit to an influencer’s wellness event, where the advice could kill
Barbara O’Neill, identified as a risk to public safety in Australia, dismisses antibiotics, vaccines and scientifically proven cancer treatment at UK conference
Aetherion Expands Houston Industrial Water Treatment Business
Aetherion expands its Houston water treatment operations. Workforce growth and added services support its strategy to acquire regional providers.
I suspected cancer lurked in my body. I hoped this test would ease my fears.
The FDA is expected to approve a new kind of blood test that may allow earlier diagnosis and less invasive, more effective treatment. But doctors warn of drawbacks.
Scientists Discover a Surprising New Effect of a Popular Blood Pressure Drug
A drug for high blood pressure could inspire future treatments for people with normal readings, thanks to an unexpected effect on the body’s energy-burning fat. Losartan already helps people control high blood pressure. New research suggests it could have a second use in activating brown fat, a tissue that burns energy to produce heat and
Guided search helps Kentuckians navigate treatment, mental health and recovery resources
A new guided search feature from FindHelpNow.org makes it easier for Kentuckians to find substance use disorder treatment, mental health care and recovery resources that fit their needs.
GLP-1 Drugs and Mental Health: Effects on Depression and Anxiety
GLP-1 receptor agonists affect pathways involved in mood, appetite, and reward, prompting research into their potential benefits for depression, substance use disorders, and binge eating. Psychiatric treatment benefits remain unproven, while conflicting observational findings and reassuring trial evidence require careful interpretation.
HOMETOWN HEALTH: Researchers identify new clues for treating type 2 diabetes
The study's authors say this could be developed into new treatments that could help people regulate their blood sugar.
President Trump signs executive order aimed at improving women's health. How could it impact you?
President Trump signed an executive order creating a women's health task force and a division at the National Institutes of Health to advance research, diagnostics, and treatments for women's health issues.
After years of backlash, Apu returns to 'The Simpsons' with a South Asian voice
The Halloween-themed episodes of “The Simpsons” have always been a treat of spooky stand-alone storylines | KNX News 1070 AM
Europe’s moderates must stop treating politics as a spectator sport
While centrists have retreated to myriad bubbles, extremists turn up, join up and organise
TriGemX Bio and TCGX Acquisition Corp. Announce Business Combination Agreement to Create Publicly Listed Company to Develop Elismetrep, A Potential First-in-Class Treatment for Migraine
TriGemX Bio, a biotechnology company focused on developing elismetrep, a potential first-in-class treatment for migraine, and TCGX Acquisition Corp. (Nasdaq:...
San Francisco techie takes down zombie video game that let players kill homeless people: 'It showed poor judgment'
The creator said that he refunded all advertisers and made a donation to a drug treatment and recovery service equivalent to the revenue generated by the game.
New UI clinic pilots exercise treatments to improve health of cancer patients, survivors
A new exercise oncology research clinic at the University of Iowa is helping people dealing with cancer and its aftermath build back strength and trust in their bodies through exercise training.
Employers Shift Rising Health Care Costs Onto Millions of Workers
New surveys show that increases in premiums and deductibles are forcing people to forgo treatments or doctor’s visits while budgets are strained by higher food and gas prices.
Seniors Left Waiting as Treatment Bill Faces Uphill Climb
This is an exclusive BHB+ story. Many adult seniors have been locked out of accessing residential addiction treatment for the sector's entire
PFAS in Agriculture: Science, Uncertainty, and Risk Communication
Summary PFAS contamination raises legitimate health and environmental concerns, but this diverse family of thousands of chemicals should not be treated as
Workers Can Govern, but They Need Power First
A new book makes the most rigorous case yet for why so few working-class people hold office. But by treating the lack of workers in office as a law of electoral democracy, its authors underrate how mu...
Sangertown Square's Trick-or-Treat Street Returns
Families can enjoy an early Halloween celebration at Sangertown Square with the annual Trick-or-Treat Street event.
Children learn about nuclear science as they trick-or-treat through Fall Fission Fest
AIKEN — Children dressed in Halloween costumes filled a downtown parkway Oct. 17, learning about nuclear science and even wielding Geiger counters at the SRS Heritage Foundation’s fourth Fall Fission ...
Milwaukee-area bakeries serve Brewers-themed treats during World Series run
From baseball cookies to blue-and-yellow bread twists, businesses are getting creative to celebrate the Brewers.
Local nonprofit empowers individuals with disabilities through pet treat business
The Ella and Bella Pet Company, a nonprofit founded by Kristine Flora, creates unique opportunities for individuals with intellectual and developmental disabilities. This innovative initiative not …
Medical College of Wisconsin gets $50M gift to advance precision medicine
Precision medicine takes into account a person's genes and lifestyle, as well as the environment they live in, to treat their health care needs.
HEALTH FIRST: Novant Health surgeon stresses early detection in breast cancer care
October is Breast Cancer Awareness Month, a time to highlight the importance of screening, early detection and advances in treatment.
Step inside NextGen, the building designed to transform the future of health
See how Mizzou scientists are turning discoveries into new ways to prevent, diagnose and treat disease.
Business owners like Hendricks and Uihleins create jobs
The voices that demand we “tax the rich” treat every successful entrepreneur as a potential villain whose gains must be redistributed or regulated.
Halloween comes alive at Senior Care Health and Rehab
With Halloween two weeks away, Senior Care Health and Rehab is hosting a Trunk or Treat on Monday, Oct. 19, from 5:30 to 7:00 p.m. at 910 Midwestern Pkwy.
Many Women Are Still Struggling to Fill Estrogen Patch Prescriptions. What to Do If You Can’t Get Yours
As demand for menopause treatment increases, estrogen patches are hard to find at pharmacies. Here’s what to do if you can’t refill your prescription.
How to Generate Evidence for RLTs? - European Organisation for Research and Treatment of Cancer
How to Generate Evidence for RLTs? - European Organisation for Research and Treatment of Cancer / cancer, EANM26, OncoDaily, Oncology
President Trump signs executive order aimed at improving women's health. How could it impact you?
President Trump signed an executive order creating a women's health task force and a division at the National Institutes of Health to advance research, diagnostics, and treatments for women's health issues.
Kenya confirms four new Ebola cases, bringing total number to seven
Oct 17 () - Kenya confirmed four new cases of the Ebola Bundibugyo virus on Saturday, including three health workers who treated the country's first patient, bringing the total number of confirmed ca...
Japanese Scientists Find Method to Support Sustainable Polyester Recycling
The process uses a supercritical carbon dioxide treatment.
Obama calls Trump officials’ investigation of Ilhan Omar ‘appalling’
The former president posted a lengthy statement calling President Donald Trump’s treatment of Ilhan Omar a “transparent” effort to intimidate her.
Would subsidizing weight-loss drugs make health care fairer?
GLP-1 medicines such as Ozempic, Wegovy and Mounjaro have transformed the treatment of obesity, but access to them in Australia increasingly depends on something much less medical: whether you can afford ...
Australian Visitor Grateful to Holy Cross Health for Saving Her Life During Fort Lauderdale Visit - Florida Hospital News and Healthcare Report
Nearly 10 months after receiving emergency treatment at Holy Cross Health for a ruptured brain aneurysm, Australian resident Sarah Frost is reflecting on her recovery and the care that helped […]
UC Davis Health introduces five-day accelerated treatment for severe depression
UC Davis Health has added an accelerated treatment approach for depression at its Advanced Psychiatric Therapeutics (APT) clinic in East Sacramento.
HOMETOWN HEALTH: New menopause care guidelines aim to improve treatment options
Doctors say awareness of menopause is spreading, but so is misinformation.
Gentle Brain Ultrasound May Help Ease Delusions in Schizophrenia
NYU Langone pilot study shows that transcranial ultrasound stimulation may safely treat delusions in schizophrenia and schizoaffective disorder. Learn more.
AI facial health recognition tools help physicians assess age and survival risk to guide personalized treatment
Researchers are using AI tools to analyze simple facial photographs to determine key indicators of a person's health. Mass General Brigham researchers built FAHR-Face (Foundation Artificial Intelligence ...
Susan Collins Says Rival’s ‘Oh, Shut Up’ Comment Reflects How He Treats Women
Ms. Collins, a Republican running in a crucial race, called the debate remark by her opponent, Troy Jackson, “very telling.” Mr. Jackson has defended his comment, and his campaign said Ms. Collins had run a campaign based on personal attacks.
Australia urged to put biodiversity at the heart of planning as global targets slip out of reach
The world is falling short of its biodiversity commitments because nature is still treated as an afterthought in decisions about housing, infrastructure, agriculture, energy, mining and conservation, ...
Where to find the best Halloween displays and treats in Knoxville
The ghosts and goblins are out! Here are neighborhoods in Knoxville to visit for a few thrills and treats on or even before Halloween night.
Landmark China trial achieves 84% efficacy treating cancer with waste water tech
Nano-carbon iron injection halts tumour growth in 16 patients, induces shrinkage in two, with Phase II trial now under way with 52 others.
DOJ charges 15 for $2 billion in fraudulent health care claims in California
The largest of the cases involved $1.6 billion in billings for what the DOJ described as “sham substance abuse treatment” in Southern California.
Feds allege $2 billion in California health care fraud, 15 charged
Federal authorities announced charges against 15 people, including six medical professionals, accusing them of health care fraud schemes worth $2 billion, including sham substance abuse treatment programs, unnecessary medical procedures and bogus hospice services.
Business Beat: Adventure Zone to host Trunk or Treat event Tuesday evening
COLDWATER, MI (WTVB) - Adventure Zone in Coldwater, Michigan, has officially announced its upcoming Trunk or T...
NMSU professors collaborate on $1.2 million NASA grant
American third grade classrooms are filled with natural-born scientists – children obsessed with asking why and treating the world as an open-ended laboratory. But as they cross the threshold into...
‘The Simpsons’ revives Apu following years of controversy
Across 38 seasons of “The Simpsons,” the Halloween-themed “Treehouse of Horror” episodes have always been a treat of spooky stand-alone storylines. On Sunday, the show surprised viewers with a majo…
Rural Health, Inc. to hold 5th annual Night of the Living Health Fair on Friday
Rural Health, Inc. will hold its annual Night of the Living Health Fair on Friday, inviting the community to trick or treat while also learning about Southern Illinois healthcare services
The National Landscape of Mental Health Treatment Courts
A national survey examines the growth of mental health treatment courts and the need for clearer standards, better data, and sustainable funding.
Business owners like Hendricks and Uihleins create jobs
The voices that demand we “tax the rich” treat every successful entrepreneur as a potential villain whose gains must be redistributed or regulated.
The New Science of Stuttering
Experts are reaching consensus on what the condition is. Now they’re debating how best to treat it.
Trunk or Treat Held at Newport City Elementary School
Trunk or Treat was held at the Newport Elementary School on Saturday, and to see a full display of photos from the event, see The Express on 10-20-26. Pictured above,
Canine cancer patients contribute to next-generation minimally invasive cancer therapies for dogs and humans
Oncologists at Purdue University pioneer protocols for tumor ablation, a less invasive cancer treatment more effective than surgery, radiation or chemotherapy, benefiting dogs and humans alike.
Could AI Use a Simple Photo of Your Face to Reveal Clues About Your Health?
A new AI model can estimate biological age and predict cancer survival outcomes using a simple photo of a patient’s face, though more research is needed before doctors will be able to use it to help them decide on treatments.
Combination nucleic acid therapies: towards personalized cancer treatment
Combination strategies enable simultaneous activation and silencing of key target genes to correct molecular pathways in pancreatic cancer.
New guided search tool helps Kentuckians navigate treatment, mental health and recovery resources
By Leah Dick University of Kentucky Finding the right support for substance use disorder treatment, mental health care, recovery housing or naloxone distribution can be an important step toward better…
NY Giants need their ballhawk deeper against Houston
Houston expects Tank Dell back Sunday. For the Giants, I would treat that as a reason to protect more space […]
Pokémon Pokopia Pumpkaboo's Sweet Surprises Halloween Event Guide, From Pumpkin Candy To Gourgeist
Treat yourself to two Ghost-types this Halloween
Start-Up Claims to Treat a Patient With A.I.-Created Viruses
Certain viruses attack bacteria and can sometimes clear antibiotic-resistant infections. Researchers said they had tailored a virus to attack one patient’s illness.
By helping sad Brad with healthcare, we help ourselves
How does it help the hospitals that treat Brad (which they will) if he cannot pay anything?
OSF HealthCare encourages improving your health literacy
Dr. Dennis Cunningham says health literacy is all about getting people engaged in their care and treating them as a partner with their health team.
Mines Museum of Earth Science event makes science spooky
Not many Halloween events send trick-or-treaters home with geodes, but the Mines Museum of Earth Science’s annual Spooktacular is one of them.
Post From Community: Halloween party at Ascension Family Health Center
Join Ascension for a spooktacular Trunk or Treat event at Ascension All Saints Family Health Center.
Low Testosterone Opens the Door to a Broader Health Conversation
Low testosterone can signal broader health concerns involving weight, metabolic health, sleep and lifestyle. Cleveland Clinic’s Mark Paulos, MD, explains why comprehensive evaluation and a whole-person treatment approach matter.
EA Sports Announces Return of 'Fight Night' Boxing Video Game, 'The Fight Is Never Over'
Retro gaming fans were given a treat on Tuesday.
'The Simpsons' resurrects Apu after nearly a decade of silence
The Halloween-themed episodes of “The Simpsons” have always been a treat of spooky stand-alone storylines. On Sunday, the show surprised viewers with the resurrection of Apu. The beloved Indian Kwik-E-Mart
Boo! Insider's guide to Halloween in Haywood
Halloween season is here and Haywood County is getting into the spooky spirit. From trick-or-treating and costume parties to haunted happenings and family-friendly fun, there will be plenty of ways
Christina Applegate’s Health Journey, From Early MS Symptoms to Learning She was Misdiagnosed
After years of treatment, hospitalizations and pain, the actor says her misdiagnosis isn’t welcome news.
Payson woman fights for coverage after health plan drops her provider, leaving her with $13K bill
Consumers have some protections when their insurance drops coverage during treatment.
Maryland Retreat Boasts a Pool and an Open-Air Entertainment Pavilion
The home is in the heart of the corridor linking Baltimore with Annapolis and Washington, D.C.
Scientists Uncover a Hidden Factor That Could Change How We Manage Diabetes
Timing may matter in insulin-treated type 2 diabetes; patients with the steadiest daily rhythms were 2.3 times as likely to meet blood sugar goals, while afternoon activity was linked to smaller swings. People with type 2 diabetes who use insulin need to keep blood glucose from climbing too high or falling too low. In a
Breast Cancer Care and Heart Health: What Black Women Need to Know
Black women face disproportionately high rates of heart disease and breast cancer mortality. Understanding how both are connected can help women advocate for screening, treatment and follow-up, say experts with Baptist Health.
Scientists uncover 3 key brain pathways linked to lasting depression relief
Researchers have uncovered three brain pathways linked to lasting improvements in people receiving deep brain stimulation for severe, treatment-resistant depression. They also discovered that patients who failed to improve after two years shared a striking pattern: insufficient stimulation of a crucial brain connection. The findings suggest that millimeters in electrode placement could make a major difference in treatment outcomes.
Rioting in France gives Trump a new talking point as he tries to stave off GOP midterm losses
As Kansans were waiting for President Donald Trump to arrive at his rally in Wichita this week, they were treated to a new addition to the pre-show program: footage of this weekend’s violent protests in France, most of it clipped from Fox News, aired on large screens.
HEALTH FIRST: Novant Health surgeon stresses early detection in breast cancer care
October is Breast Cancer Awareness Month, a time to highlight the importance of screening, early detection and advances in treatment.
New unit aims to fill gaps in mental health care for NC youth in juvenile detention
The 10-bed unit will provide intensive treatment to young people with acute behavioral health needs who struggle to find placement in other facilities.
Dog cognitive decline treatment: USF Health develops new gene therapy
Researchers at the University of South Florida are developing a gene therapy injection aimed at treating canine cognitive decline. The team hopes the one-time treatment will target the disease directly and give pets more quality time with their families.
Meta tells Brazil's electoral court it gives equal treatment to Lula and Flávio Bolsonaro
Meta said it had "completed the implementation of measures to comply with the directive from the electoral court."
Regional Science Consortium Researching Harmful Algal Blooms
If you've noticed large buoys or boats out on the bayfront and wondered what they were, you're not alone. The Regional Science Consortium is collaborating with Princeton Hydro on a research project funded by the U.S. Army Corps of Engineers to study ways to control harmful algal blooms. Dr. Jeanette Schnars, the Executive Director of the Regional Science Consortium, explained the goal of the research."We are researching different ways to control blue-green algae, which creates harmful algal blooms and releases toxins," Dr. Schnars said.The project aims to identify potential techniques for controlling harmful algal blooms in Presque Isle Bay.Schnars explained that people may notice circular floats in the water near Perry's Landing and Liberty Park. Those floats are part of the testing process."You might see a circular float, almost like a hula hoop, that is out in the bay, near Perry's Landing and Liberty Park area, and those limn corrals go all the way to the bottom. And what we will do are some treatments within the limn corral in the bottom," Schnars said.After samples are collected, they are brought back to the laboratory at the Tom Ridge Environmental Center for analysis."A lot of those samples are coming back here. We are going to test them for the harmful algal bloom toxins before, during, and after, and see how effective the testing was," Schnars said.Sarah Magyan, an aquatic biologist with the Regional Science Consortium, explained that the team also collects samples from locations throughout the region."We pull samples every week from 30 different sites, and then we bring those back here, we preserve them and run them through the ELISA test," Magyan said.Schnars said researchers hope the results will help them develop effective ways to reduce harmful algal blooms in the future."If we can do some treatments over space and time in upcoming seasons, we may be able to reduce the number of harmful algal blooms we have in this area," Schnars said.The research is also important for public and animal safety. Magyan explained that toxins produced by certain algae can affect the skin, nervous system or liver.While toxin levels may be low for people, she emphasized the importance of protecting pets that swim in local waterways."Toxins can either be skin toxins, nerve toxins, or liver toxins. While we have low levels for people, it is important that we are keeping our pets safe because we recreate with our animals in the water, and we see hundreds and hundreds of dogs on Presque Isle and the rest of the shoreline," Magyan said.Testing began in September, and Schnars said researchers expect to conduct at least another six to eight weeks of testing to better understand the effectiveness of the treatments.
Jalen Hurts' health shouldn't be up for debate
Football has long tradition of treating Black quarterbacks injuries as character referendums first and medical event second.
Supreme Court rejects Trump's order to end hormone treatments for transgender prisoners
The decision is a rare win for trans rights at the Supreme Court.
Mucins are her mission: Stacy Malaker carves a new path in the fight against cancer and other diseases
In a new Q&A, Yale chemist Stacy Malaker tells the story of how she helped develop a new field of research and the potential it has for detecting and treating disease.
Old Forge Library offers free Halloween activity bags for children
Old Forge Library offers free Halloween Grab N' Go craft bags for children ages 4-11, plus a Halloween party and trick-or-treating activities.
10 fun trunk-or-treat events for families to try in metro Phoenix
It's not too late to plan your trunk-or-treat events for the family. Here are 10 to try in metro Phoenix for Halloween.
Changing the mental health conversation, one swing at a time
Next18, a Wisconsin-based nonprofit, offers retreats for military veterans and first responders that combine the game of golf with mental wellness education.
Seniors Left Waiting as Treatment Bill Faces Uphill Climb
This is an exclusive BHB+ story. Many adult seniors have been locked out of accessing residential addiction treatment for the sector's entire
The Republican governor candidates walking back some of their abortion stances
The candidates’ retreat suggests that, even as reproductive rights fade from the national spotlight and polls show voters are far more likely to prioritize cost-of-living concerns, the political ramifications of pushing for new abortion restrictions remain substantial.
New drug reverses severe fatty liver disease by repairing the gut
Scientists have discovered that a potential new drug can reverse severe fatty liver disease in animal models by restoring gut health and blocking harmful substances from reaching the liver. The breakthrough could pave the way for new treatments for liver disease and potentially other serious conditions, including cardiovascular disease.
The immortal jellyfish can beat ageing and death. Its genetics could help human cells rejuvenate
The immortal jellyfish is capable of winding back its lifecycle to become young again. Scientists are unlocking its cellular secrets for new strategies to treat diseases of old age.
Axena Health Named Finalist for the Digital Health Hub Foundation - Digital Health & AI Awards 2026 at HLTH
NEWTON, Mass., October 20, 2026--Axena Health, Inc. (Axena Health), a women’s health company redefining the standard of care for pelvic health conditions through clinically proven, non-invasive treatments, today announced it has been named a finalist for the Digital Health Hub Foundation – Digital Health & AI Awards 2026 at HLTH. Selected from a pool of more than 1,300 participating companies across all tracks and categories, Axena Health is recognized in the Best in Class Track for Women’s and
Mines Museum of Earth Science event makes science spooky
Not many Halloween events send trick-or-treaters home with geodes, but the Mines Museum of Earth Science’s annual Spooktacular is one of them.
How a photo of a person’s face could help predict whether they’ll survive cancer treatment
A simple selfie could hold surprising clues to your overall health and longevity, especially among people with cancer.
AIPAC retreats from candidate endorsements and direct giving as political backlash grows
Pro-Israel group AIPAC will keep operating its United Democracy Project super PAC while mobilizing individual donors to give directly.
Pope Leo won’t need additional treatment after cancer surgery
Doctors removed the lower lobe of the Chicago-born pontiff's right lung.
M42 CEO on AI, genomics and the future of healthcare
M42 Group CEO Dimitris Moulavasilis discusses how the Abu Dhabi-based healthcare company is combining artificial intelligence, genomics and clinical services to reshape healthcare. He explores the group’s international expansion, the Emirati Genome Programme and the potential for technology to help doctors identify health risks earlier and move healthcare towards prevention rather than treatment.