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Sharon Stone knew her marriage was 'over' when husband questioned her getting mastectomy despite massive tumor
Actress Sharon Stone said she knew her marriage was finished when her then-husband was 'furious' with her decision to get a double mastectomy after doctors found tumors in her breasts: 'He was done with me then.'
Team IMPACT CEO Krissie Kelleher understands the healing power of sports, teamwork and community
Krissie Kelleher used lessons from her lacrosse career to guide her daughter through surgeries and treatment for a spinal cord tumor. Witnessing how sports helped her daughter heal emotionally and physically inspired Kelleher to lead Team IMPACT, a national nonprofit connecting children facing serious illness with NCAA sports teams. Today, the organization partners with more than 400 schools and 1,100 teams to help kids build confidence, find community and experience hope through teamwork.
Jason Collins, NBA's first openly gay player, dies at 47 of brain tumor
Collins spent 13 years as a player in the league for six different franchises.
How an ‘Impossible’ Idea Led to a Pancreatic Cancer Breakthrough
The new strategy also holds promise for lung and colon tumors. Here’s how scientists discovered it.
Scientists say house cats could help unlock new cancer treatments for humans
Scientists have cracked open the “black box” of feline cancer in a landmark study that genetically analyzed nearly 500 cat tumors from around the world. The research uncovered striking similarities between cancers in cats, dogs, and humans — including shared cancer-driving genes tied to aggressive breast cancers.
USC scientists discover how to create a never-ending supply of cancer-fighting cells
USC scientists have discovered a way to create a potentially renewable supply of genetically engineered immune cells that can attack cancer and strengthen the body's natural defenses. By growing and modifying immature immune cells rather than mature ones, researchers developed a system that can continuously produce tumor-fighting cells inside the body.
Meet Iris Shen, the 17-year-old Texas student who used clams as a model for testing blood-cancer drugs, found a drug combination that slowed tumor growth, and won a $150,000 Regeneron Science Talent Search prize
Iris Shen, a 17-year-old student from The Woodlands, Texas, has earned third place and a $150,000 award in the 2026 Regeneron Science Talent Search for an unusually creative approach to blood-cancer research. Instead of relying only on conventional laboratory models, Shen tested a potential cancer drug in clams to determine whether these animals could serve as an animal model for blood-cancer drug discovery.
New AI tool predicts cancer spread with surprising accuracy
Researchers have discovered that cancer spread isn’t random—it follows a kind of biological “program.” By studying colon tumor cells, they identified gene patterns that signal whether a cancer is likely to metastasize. Their AI model, MangroveGS, can predict this risk with about 80% accuracy and even works across multiple cancer types. This could transform how doctors decide who needs aggressive treatment and who doesn’t.
Cancer may be breaking its own DNA to keep growing
Cancer cells rely on powerful genetic switches to keep growth genes running at full speed, but that intense activity can damage their own DNA. The resulting breaks are repeatedly repaired, sometimes with small mistakes that allow new mutations to accumulate. Researchers believe this self-inflicted damage may help tumors evolve while also creating a potential target for new treatments.
Around the MHS
The latest news from around the Military Health System for the week of April 6-10, 2026, includes Uniformed Services University research on aggressive tumors, an award for expanding access to mental health care, and a new self-test for HPV.
Ilyas Sahin: A New Science Study on Tumors Weaponizing Antioxidants
Ilyas Sahin: A New Science Study on Tumors Weaponizing Antioxidants / Alberto G. Conti, Alexander C. Evans, Alexander J. Wesolowski, Alica Nübling, Andrew M.
How aggressive breast cancer turns off the immune system
Researchers are launching a new project to crack the mystery of aggressive breast cancer, where predicting disease progression remains a major hurdle. By studying how tumors interact with and suppress the immune system, scientists aim to identify new biomarkers that reveal how the cancer evolves. Using real patient samples, the team hopes to turn earlier discoveries into practical clinical tools. The goal: more precise, personalized treatments that can outsmart even the most dangerous tumors.
Busy Philipps shares health update after brain tumor diagnosis
Busy Philipps, who was diagnosed with a brain tumor, opened up about the health scare during a recent appearance on the \
Marshall Health Network enrolling patients in lung cancer clinical trial evaluating personalized immunotherapy approach
lungllulungHUNTINGTON, W.Va. – The Edwards Cancer Institute at Marshall Health Network (MHN) is enrolling eligible patients in a clinical trial evaluating whether a personalized immunotherapy approach can enhance the effectiveness of treatment following lung cancer surgery. The study is investigating the use of an individualized therapy designed with a tumor’s unique biology from a surgical sample to help the immune system better […]
'Bachelorette' alum Joe Amabile gives health update on brain tumor
"Bachelor in Paradise" alum Joe Amabile and his wife Serena Pitt both shared updates on his health after a brain tumor surgery.
Scientists discover vitamin B2 may help cancer cells survive
Scientists have uncovered a surprising dark side to vitamin B2: it may help cancer cells stay alive. The vitamin supports a cellular shield that protects tumors from ferroptosis, a form of programmed cell death linked to cancer suppression. In lab tests, researchers used a vitamin B2-like compound called roseoflavin to break down that protection and trigger cancer cell death.
Popular Weight Loss Drugs May Have Surprising Side Effect: Stalling Cancer
A suite of new studies suggest drugs such as Ozempic and Zepbound might slow tumor progression and improve survival, but more research is needed to confirm the findings.
Is healthcare on Florida's ballot? Many voters say it's a top priority
An Orlando woman survived after a brain tumor that grew unchecked for seven years because she couldn't get the insurance necessary to see a doctor. She now supports candidates who favor Medicare for all.
Oscar Schmidt, Basketball Hall of Famer from Brazil, dies at 68
The Olympian and Basketball Hall of Famer died after a more than 15-year battle with a brain tumor, the family said.
Ex-ESPN Star David Pollack Shares ‘Stunning’ Health Update About Wife’s Brain Tumor
'Thank you for faithfully praying!'
One fat helped pancreatic cancer grow while another cut disease in half
A surprising new study suggests that when it comes to pancreatic cancer, the kind of fat you eat may matter more than how much. Researchers found that oleic acid—the main fat in olive oil and several other common foods—sped up tumor growth in mice predisposed to pancreatic cancer, while omega-3-rich fats from fish oil dramatically slowed disease development.
Scientists discover why cancer drugs don’t work for everyone
Scientists have uncovered a hidden reason why cancer treatments don’t work equally well for everyone. Certain drugs can become trapped inside lysosomes within tumor cells, forming slow-release reservoirs that create uneven drug distribution. This means some cancer cells are heavily exposed while others are barely affected. Understanding this process could help doctors better tailor treatments and improve outcomes.
Scientists solve a 30-year rye pollen mystery that could transform cancer research
Scientists have finally solved a nearly 30-year-old mystery surrounding two unusual molecules found in rye pollen that once showed an intriguing ability to help animals fight tumors. By determining their exact 3D structures, researchers have unlocked the blueprint needed to investigate how these natural compounds interact with the immune system and which parts may be responsible for their cancer-fighting effects.
New Orleans hospital offers new radiotherapy that tracks tumors during treatment: 'More precise, more personal'
"Less recurrence. More cure. Less side effects. Better patient experience," said Dr. Christophe Marques, a radiation oncologist with Ochsner Health.
Scientists decipher how T cells sense enemies—such as cancer—at point of contact
Every encounter between a T cell and a potential target—especially when that target is a developing tumor—begins with a rapid series of molecular decisions. Within seconds, the immune cell must determine ...
Scientists finally solved how a common gut bacterium triggers colon cancer
Researchers solved a long-standing mystery behind how a bacterial toxin associated with colorectal cancer damages the colon. The toxin first binds to a receptor called claudin-4, giving it access to attack the cells' protective barrier. After identifying this weak point, the team designed a decoy protein that successfully blocked the toxin in mice. The discovery could pave the way for new therapies to prevent inflammation and colon tumors.
Inside Iowa Politics: Emotional farewell speech from Sen. Jack Whitver
State Senator Jack Whitver gave his retirement speech as he prepares to leave office to continue his treatment for a brain tumor.
Inside Iowa Politics: Emotional farewell speech from Sen. Jack Whitver
State Senator Jack Whitver gave his retirement speech as he prepares to leave office to continue his treatment for a brain tumor.
From cancer survivor to chief of AI at UCLA Health
While learning about brain tumors in medical school, Dr. Paul Lukac discovered he had one.
A machine learning system that identifies cancer cells based on how they scatter light
Cytology tests are widely used for cancer screening, but diagnosis can be challenging when tumor and non-tumor cells look very similar. Researchers from Japan developed a machine learning system that identifies tumor cells based on their white-light scattering spectra. The approach achieved high diagnostic accuracy for mesothelioma and showed potential for distinguishing several other tumor types, offering a promising approach for enhancing cytological diagnosis.
Smart nanoparticles light up brain cancer and destroy what surgery misses
Scientists created smart nanoparticles that can both illuminate hidden glioblastoma cells during surgery and destroy microscopic cancer left behind afterward. In mice, the treatment prevented recurrence and led to 100% survival at 60 days, though it has not yet been tested in humans.
This pet gecko could help scientists unlock the secrets of cancer
An unusual leopard gecko that naturally develops aggressive tumors may become an important new model for cancer research. Scientists found its tumors share key genetic changes with human cancers, offering a rare opportunity to study the disease as it develops naturally.
UToledo Health Performs Northwest Ohio’s First Histotripsy Procedures
Histotripsy uses focused sound waves to break down tumors without incisions, heat or radiation.
New vitamin B12 therapy shows promise against deadly brain cancer
Researchers have identified a vitamin B12–based compound that can cross the blood-brain barrier and home in on glioblastoma tumors. In animal studies, the compound accumulated preferentially in tumor tissue and delivered sustained nitric oxide directly to cancer cells. It also worked synergistically with existing glioblastoma treatments, significantly enhancing their tumor-fighting effects.
He was headed to medical school orientation. Instead, doctors found a brain tumor.
This 24-year-old was about to start medical school. Instead, a visit to the ER down the street turned into a brain tumor diagnosis.
Inside Iowa Politics: Emotional farewell speech from Sen. Jack Whitver
State Senator Jack Whitver gave his retirement speech as he prepares to leave office to continue his treatment for a brain tumor.
Scientists find hidden brain cells helping deadly cancer grow
Scientists in Canada have uncovered a surprising weakness in glioblastoma, one of the deadliest brain cancers. They found that certain brain cells—once believed to only support healthy nerves—can actually help tumors grow by sending signals that strengthen cancer cells. When researchers blocked this communication, tumor growth slowed dramatically in lab models.
Christ Hospital Health Network first in country to install, use new CT scanner
The system supports consistent CT imaging to help doctors visualize tumors and plan for treatment.
New drugs could wipe out the “zombie cells” linked to cancer and aging
Researchers found a new way to kill harmful “zombie” cells that linger after chemotherapy and help cancers become more aggressive. These senescent cells survive by relying on a protective protein called GPX4, even while sitting on the edge of a deadly iron-triggered collapse. New drugs remove that protection, causing the cells to self-destruct. In mice, the approach reduced tumor size and boosted survival, hinting at a promising new cancer therapy.
Scientists turn probiotic bacteria into tiny drug factories for pancreatic cancer
Engineered probiotic bacteria were able to infiltrate pancreatic tumors, stimulate cancer-fighting immune cells, and slow tumor growth in animal studies. Even more strikingly, the treatment worked better when combined with chemotherapy, radiation, or immunotherapy.
ECU Health Medical Center performs its first procedure with Edison® Histotripsy System
New non invasive therapy brings advanced liver tumor treatment closer to home in eastern North Carolina
‘My outlook is very positive;’ Local brewery founder gives update on recent health concerns
In a statement on Thursday, founder Steve Barnhart said a Stage 2 tumor was found on one of his kidneys in early April.
Scientists discover why this deadly lung cancer keeps coming back
Scientists have discovered that losing a key protein in small cell lung cancer triggers inflammation that actually helps tumors grow and spread. Even more surprising, it pushes cancer cells into a more aggressive, neuron-like state linked to relapse.
FDA-approved drug may finally help immunotherapy defeat rare liver cancer
Researchers found that a rare liver cancer evades immunotherapy by luring immune T cells away from the tumor and trapping them in nearby fibrous tissue. An FDA-approved drug called AMD3100 freed those T cells to attack the cancer, significantly improving the effectiveness of immunotherapy in tumor samples.
BayCare opens proton therapy center at Tampa's St. Joseph’s Hospital
Florida's west coast gets another option for the radiation option, which uses charged particles called protons to target tumors while limiting exposure to surrounding healthy tissue.
Doctors at Henry Ford Health in Detroit perform world-first GammaTile procedure on spinal tumor
A team at Henry Ford Health in Detroit has performed what is believed to be a world-first procedure, adapting a brain cancer technology to treat a spinal tumor.
Maternal genes enable trophoblastic tumor relapse after immunotherapy
Cell-to-cell transfer of maternal genetic material may provide trophoblastic tumor cells with new functions.
Florence community rallies for local business owner diagnosed with brain tumor, here’s how you can help
The Florence community held a fundraising event for a local business owner who was diagnosed with a brain tumor for the second time.
NYC Health + Hospitals/Kings County Successfully Performs Its First Breast Tumor Cryoablation Procedure
NYC Health + Hospitals/Kings County has successfully performed its first breast tumor cryoablation procedure, marking a significant milestone in advancing
A promising fatty liver treatment may raise cancer risk
A surprising new study reveals that blocking a supposedly protective enzyme, Caspase-2, could actually backfire—raising the risk of chronic liver damage and cancer over time. Researchers found that without this enzyme, liver cells grow abnormally large and accumulate genetic damage, leading to inflammation, scarring, and eventually tumors, especially with age. While inhibiting Caspase-2 may offer short-term benefits, such as reducing fatty liver disease, the long-term consequences appear dangerous.
A common sugar may help cancer cells break free and spread
Chemotherapy-surviving ovarian cancer cells may release fructose to help neighboring tumor cells loosen, escape, and spread. The discovery suggests that sugary diets and cholesterol-lowering drugs could influence cancer progression, though the effects have not yet been confirmed in patients.
Scientists discover an unexpected way to make pancreatic cancer cells self-destruct
Researchers tested experimental PCAI compounds against pancreatic cancer cells and found they had powerful anticancer effects. One leading compound blocked more than 90% of cancer cell migration, suggesting it could help prevent the spread of tumors. Rather than suppressing cancer signaling, the treatment hyperactivated key pathways until the cells essentially self-destructed.
GSK sees blockbuster potential in targeted cancer therapy after promising early data
British drugmaker GSK's experimental targeted cancer drug Mo-rez has blockbuster potential, its head of oncology research has told reporters, after early data showed the drug helped shrink tumors in patients with advanced, hard-to-treat cancers.
How worried should Catholics be about the pope’s health?
Pope Leo XIV announced on Sunday that he will undergo surgery this week to remove a “nodule” from his lung. The pope made the announcement at the end of his Sunday Angelus address, asking for prayers. “Dear all, recently, during some checkups, the doctors discovered a nodule in my lung. It was detected at a very early stage and was well-localized,” Leo said. “The doctors felt it was necessary to intervene, and so, following their advice, I decided to have surgery to remove it. The procedure is already scheduled for the next few days. I thank you for your spiritual support and I entrust myself to your prayers.” The Vatican press office subsequently added that Leo is scheduled to undergo surgery at the Gamelli hospital on Tuesday, Oct. 13. The pope is expected to spend up to a week in the Gamelli recovering, after which, for the moment, he is still expected to undertake his largest and longest to-date Apostolic journey, heading to Argentina, Uruguay, and Peru, beginning Nov. 6. Prayers have, understandably, poured in from dioceses around the world, accompanied by the best wishes of heads of state and international institutions. So how worried should Catholics be for the health of the pope? The Vatican’s messaging around Leo’s pending surgery is, in many ways, a new approach to papal health issues. But, despite the pope’s personal candour, the Holy See’s messaging perhaps raises as many questions as it answers. Subscribe — Leo’s decision to announce his own medical status and pending hospital stay during the Sunday Angelus is, it should be said, already something of a big deal. Traditionally, the health of popes simply hasn’t been discussed publicly or officially, until circumstances made it absolutely necessary. Memorably, in 2023 Pope Francis was rushed to the Gemelli in an ambulance, exhibiting signs of cardiac arrest according to many close to him, only for the Sala Stampa to put out a statement insisting he was merely going in for “pre-scheduled” tests. That Pope Leo has decided to announce his condition himself, with remarkable frankness, is a significant comms policy shift around the Apostolic Palace. This might reflect a deliberately more open posture, as opposed to the traditional, otiose evasiveness, and the first fruits of an American pope and American prefect of the Dicastery for Communications favoring honesty as a baseline. Equally, it must be allowed, it could be that the pope’s situation is serious enough that there would be no keeping it under wraps or playing it off, and the decision was made to be as open as possible to head off speculation about the papal health. Certainly, Leo appeared to make every effort to sound reassuring — stressing that, whatever the diagnosis is, exactly, it is “well-localized” and “early stage.” Of course, for everyone listening, talk of a “nodule” in a lung will immediately send thoughts — and prayers — running to concerns about words not used, like “cancer,” “tumor,” “begnin” or “malignant.” To be clear, none of those words may yet be medically appropriate. And there is every reason to believe and assume that Leo is giving almost as much information as he may have himself at this stage. But the context of the pope’s announcement and the timing of his surgery do reasonably raise reasonably serious concerns for Leo. We don’t know, and this isn’t to say anyone has the right to expect to know, when the routine medical checks made this discovery. It could have been last week, last month, or even earlier. As such, it isn’t really possible to say with what kind of urgency Leo is being brought in for surgery. However, there is clearly some serious urgency to the matter. Leo making the announcement and going into hospital this week, of all weeks, means he is having to miss the balance and conclusion of his global meeting of the heads of the world’s bishops conferences, which he convened in Rome this week. That, as the Vatican has announced, has meant some serious changes to the schedule, with the newly minted dean of the College of Cardinals, Cardinal Tagle, subbing in for the closing Mass on Wednesday, and the meeting’s organizers announcing that the final working document/summary of the meeting being delayed until Leo can read and feed into it. Those changes suggest that the timing of Leo’s surgery isn’t of his own choosing, and he is acting on the best medical advice he can get by moving urgently. Had this issue been discovered weeks ago, it seems reasonable to assume the pope would have seen it dealt with before the meeting began. And were it possible to delay it, even by a few days to allow the meeting to conclude as scheduled, the expectation would surely be he’d have opted for that. It cannot be excluded that Leo is simply having to fit in with the schedules of his medical team, but a man who occupies arguably the most important and prominent role in Italy, if not Western Europe, could generally be assumed to be the one whose calendar others work around. All this points to a very recent medical discovery leading to a “days matter” diagnosis, or at least suspected possible diagnosis. Of course, another factor weighing in the balance is Leo’s upcoming apostolic visit to three South American countries, including a return to Peru, where he spent many years as a priest and bishop. It is entirely possible that the doctors, and the pope himself, are more concerned about the potential knock-on effects of surgery, and the time needed for recovery, for a 71-year-old — even one as physically sound and actively sporty as Leo. The pope is due to depart Rome November 6 for his 10-day three-country trip, returning on Nov. 17. It may be that Leo has simply made the decision to allow maximum time for his own post-op recovery, and even allow for potentially unforeseen circumstances, so that he is at full strength for the landmark trip. While it might be an inconvenience, and clearly a last-minute wrench in the works for the Amoris meeting, it is possible that Leo simply weighs the importance of that conference more lightly in the balance than even the possibility of missing his homecoming trip to Peru, or even having to scale back his itinerary for the trip. If that is the case, it would suggest a real abundance of caution by the pope approaching his Latin American tour, and a sobering indication of where Leo ranks the non-synodal meeting currently underway in Rome. In any event, what can be said for certain is that the pope having to take this, of all weeks, out of his schedule for surgery and an extended hospital stay is extremely unfortunate timing. It is clear that this is a decision Leo has made on the advice of his doctors. Together, they clearly consider that the risks of delaying, even by a little as a few days, represents an unacceptable risk for the pope. Even expecting and allowing for Leo’s full and speedy recovery, that should be a very sobering thought for Catholics everywhere. Subscribe
Biodegradable implant can deliver targeted cancer immunotherapy while protecting healthy tissue
Scientists at Houston Methodist Research Institute have developed a biodegradable implant designed to deliver cancer-fighting immunotherapy drugs directly into tumors over an extended period, a strategy ...
Zhen Xu Receives Golden Goose Award from the American Association for the Advancement of Science
This award recognizes transformative work enabled by federal funding, which was crucial to advancing the tumor-destroying soundwaves until they were ready for the clinic.
Scientists supercharge natural killer cells to fight aggressive cancers
Scientists at McGill University have found a way to supercharge the immune system’s natural killer (NK) cells, helping them break through the defenses tumors use to stay alive. By temporarily blocking two proteins, researchers turned these cells into far more effective cancer fighters against difficult cancers like leukemia, glioblastoma, kidney cancer, and triple-negative breast cancer.
Vanderbilt Health performs nation’s first breast cancer surgery using intraoperative PET-CT scan technology
The novel imaging technology provides surgical teams with a real-time view of tumor margins in the operating room.
Scientists find a weak spot in one of the deadliest brain cancers
Researchers may have found a new way to weaken glioblastoma’s defenses against treatment. Blocking a protein called SET prevented tumors from forming in preclinical models, while targeting related proteins made cancer cells more vulnerable to radiation. The strategy works by restoring activity of PP2A, an enzyme that glioblastoma cells appear to suppress. Human testing will be needed to determine whether the approach is safe and effective.
Experimental drug doubles one-year survival in pancreatic cancer
A new drug that works by making tumors more susceptible to chemotherapy and the immune system has increased survival in those with advanced pancreatic cancer in a trial.
'Bachelorette' star reveals brain tumor diagnosis after routine health scan
Joe Amabile revealed a routine health scan uncovered a blueberry-sized glioma in his brain, and he now faces a craniotomy in just two weeks.
Scientists successfully transfer longevity gene and extend lifespan
Scientists at the University of Rochester pulled off a remarkable experiment: they transferred a longevity-related gene from the famously long-lived naked mole rat into mice, and the mice ended up healthier and lived longer. The special gene boosts production of a substance called high molecular weight hyaluronic acid, which appears to protect against cancer, reduce inflammation, and support healthier aging. The modified mice showed stronger resistance to tumors, healthier guts, and lower levels of age-related inflammation.
Meet Mythreya Dharani, the 18-year-old New Jersey student who built an AI model to predict how individual tumors will respond to the chemotherapy drug cisplatin
Mythreya Dharani’s achievements in the high school science research arena are few and far between. The Society for Science, which organizes the prestigious Regeneron Science Talent Search, announced that 18-year-old Mythreya from New Jersey developed an AI model to predict how individual tumors would respond to the chemotherapy drug cisplatin.
‘Bachelor’ star Joe Amabile reveals diagnosis with early stage brain tumor, will undergo surgery
Beloved ‘Bachelor’ Nation star Joe Amabile says that his doctors detected a ‘blueberry-sized’ tumor in his brain after he underwent a full-body scan. He is scheduled for a craniotomy in two weeks.
Scientists engineer ready-to-use cancer-fighting T cells for solid tumors
T-cell receptor, or TCR, therapy is a cancer treatment that genetically reprograms immune cells, called T cells, to hunt down cancer with precision. It's similar to another treatment, CAR T-cell therapy, ...
The COVID-19 vaccine may offer brain cancer patients a surprise benefit
A recent shot of the COVID-19 vaccine doubled survival time in glioblastoma patients who had undergone tumor biopsy or surgery.
Scientists discover metabolite fueling aggressive brain tumor growth
Virtually all high-grade, aggressive gliomas in adults accumulate massive amounts of a metabolite called guanidinoacetate (GAA) that overstimulates nearby neurons and promotes tumor growth, according to new research from scientists at Children’s Medical Center Research Institute at UT Southwestern (CRI) published in Cell.
Memorial fund honors patient whose life was saved by Vanderbilt Health neurosurgeons
Charlotte Davis underwent groundbreaking brain mapping surgery at Vanderbilt Health in 1995 to treat a deep-seated brain tumor. The procedure preserved areas controlling speech and movement. She lived 30 more years after her surgery.
Lung tumor signals may tamp down food intake
Researchers found that a high-fat diet in mice amplifies nerve signals between certain lung cancers and the brain, leading to reduced appetite and weight loss.
Meet a Health Hero Finalist: Sharon Pervez-Khan
After her daughter Elora was diagnosed with an incurable, cancerous brain tumor, the Villanova mom made it her mission to accelerate research, funding, and life-saving treatment.
Supercharged “natural killer” cells could be a powerful new cancer weapon
Researchers have found a way to supercharge natural killer cells, powerful immune cells that can attack cancer, so they can penetrate solid tumors and keep fighting once inside. In mice, these specially prepared tissue-resident cells slowed the growth of several tumors, including melanoma and head and neck cancers, and worked even better when paired with the antibody drug cetuximab.
UF Health to host seminars on platelet-rich plasma therapy and brain tumor care
Seminar to be held on Wednesday at Hilton University of Florida Conference Center.
Scientists find breast cancer cells hiding behind protective “shields”
Researchers have mapped breast tumors in striking detail and uncovered hidden pockets of dormant cancer cells that may help explain why cancer can return after treatment. Unlike rapidly dividing cells, these quiet cells can essentially hibernate, allowing them to evade chemotherapy and reactivate later. The team found that they are often surrounded by immune cells and connective tissue cells that may act like a protective shield.
Color Health moving deeper into cancer services, complete with virtual 'tumor boards'
Color Health, which coordinates cancer screening, is moving into a gap it observed — obtaining and coordinating actual cancer care.
FDA Blocked Melanoma Drug as Confusion Reigned Under Makary
A third of patients in a clinical trial had tumors shrink while taking a genetically engineered treatment known as RP1.
How Scientists Finally Cracked RAS in Pancreatic Cancer
How a half century of basic science, public funding, and human persistence unlocked a way to target one of cancer’s most elusive drivers — and treat one of its deadliest cancers.
Marshall Health Network first in West Virginia to offer histotripsy treatment for liver tumors
HUNTINGTON, W.Va. – Marshall Health Network–Cabell Huntington Hospital (CHH) is the first hospital in West Virginia to treat liver tumors using the Edison® Histotripsy System, giving patients access to an advanced treatment that targets tumors with focused sound waves instead of surgery, chemotherapy or radiation. The Edison Histotripsy System uses image-guided sonic beam therapy to precisely target […]
A common vitamin could help fight one of the deadliest brain cancers
A clinical trial is exploring whether high doses of vitamin B3 could give patients with glioblastoma a better chance against the aggressive brain cancer. Scientists found that niacin may help revive immune cells that tumors shut down, allowing them to attack cancer more effectively. Early results have been promising, with patients showing significantly better progression-free survival than expected.
Scientists Discover The Fourth Transmissible Cancer Known To Science
Scientists found the fourth type of transmissible cancer, and the first in a fish: a melanoma whose tumor cells spread between catfish in a Vermont lake.
Scientists finally crack an “undruggable” pancreatic cancer target and nearly double survival
For decades, pancreatic cancer has been one of the most lethal cancers, with few effective treatment options. A new drug, daraxonrasib, targets the KRAS mutation that fuels most pancreatic tumors—something many scientists once thought couldn't be done. In a major clinical trial, the treatment nearly doubled survival for patients with advanced disease and reduced the risk of death by 60%.
Scientists Built a Molecule From Ordinary Atoms—and It Doubled Survival for a ‘Hidden’ Cancer
One giant molecule grabs the mutant proteins behind runaway tumor growth—and refuses to let go.
Genialis and Inventia Life Science Collaborate to Link Patient Biology with 3D Pancreatic Cancer Models
HOUSTON & SYDNEY, September 23, 2026--The Genialis Supermodel and Inventia's RASTRUM 3D cell model platform together will build models of PDAC that better represent tumor biology.
Canine cancer patients contribute to next-generation minimally invasive cancer therapies for dogs and humans
Oncologists at Purdue University pioneer protocols for tumor ablation, a less invasive cancer treatment more effective than surgery, radiation or chemotherapy, benefiting dogs and humans alike.
A simple supplement could help the immune system fight cancer and viruses
Low arginine levels may allow cancer cells and viruses to slip past the immune system by reducing production of a crucial cellular warning protein. In mice, arginine-rich diets led to fewer colon tumors and milder viral infections, suggesting a simple supplement could have powerful therapeutic potential.
Inside Iowa Politics: Emotional farewell speech from Sen. Jack Whitver
State Senator Jack Whitver gave his retirement speech as he prepares to leave office to continue his treatment for a brain tumor.
UVA Health study examines incision-less liver tumor treatment
UVA Health researchers reviewed outcomes from nearly 1,000 patients treated with a procedure called histotripsy.
Scientists discover why some cancers survive chemotherapy
Scientists have uncovered a surprising new trick used by one of cancer’s most notorious proteins. MYC, already infamous for fueling runaway tumor growth, also appears to help cancer cells survive by repairing their damaged DNA — including damage caused by chemotherapy and radiation. Researchers found that MYC can rush directly to broken DNA and recruit repair machinery, effectively helping tumors recover from treatments meant to destroy them.
Nathan J. Nordmann, M.D., Joins Baptist Health Miami Neuroscience Institute as Director of Spinal Oncology and Co-Director of Spinal Radiosurgery
August 27, 2026 – Fellowship-trained neurosurgeon Nathan J. Nordmann, M.D., has joined Baptist Health Miami Neuroscience as director of spinal oncology and co-director of spinal radiosurgery. He specializes in the surgical treatment of conditions affecting the brain and spine, with advanced expertise in primary and metastatic spinal tumors, complex spinal pathology and minimally invasive surgical techniques. […]
Stanley M. Gartler, Pioneer in Cancer Research, Dies at 102
He provided the first convincing evidence that cancerous tumors develop from a single mutated cell and later helped expose contamination by cells taken from Henrietta Lacks.
Scientists turn cancer-promoting protein into a weapon against tumors
Researchers have discovered that a protein known to help cancer cells thrive can also make immune cells more effective at destroying tumors.
Health Rounds: New dye for MRI exams detects lung cancer earlier
Hello Health Rounds readers! Today we highlight a potentially game-changing experimental contrast agent for MRI exams that may enable detection of lung cancer when tumors are small and more treatment options are available. We also report on a Johnson & Johnson antidepressant that appears to help improve sexual dysfunction in patients with major depressive disorder.
Microbiome science merges with oncology for better cancer treatments
Cancer remains notoriously difficult to treat, partly because tumors co‑opt their surrounding environment, including the resident microbiota, to evade immune surveillance and resist conventional therapies.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. 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