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All My Hobbies Are Getting Slopped Up, And It’s Exhausting
The explosion in vibe coding has created an endless sea of drive-by, unserious, and unmaintained software that is attacking the communities around them.
UPMC Health Plan's Food as Medicine Pilot for Members With Diabetes
The pilot pairs grocery stipends and community health worker support with members who have unmanaged diabetes and unmet social needs.
Omaha Science Café Explores the Wild World of Spiders Oct. 27
UNL biologist Eileen Hebets, PhD, presents a talk on spiders at the Oct. 27 Omaha Science Café at the Rathskeller Bier Haus. Open to ages 21 and older.
Heat’s Giannis Antetokounmpo reveals where chemistry stands with Bam Adebayo
Are the two Heat stars getting along?
Digital Science Helps Japanese Medical Affairs Researchers Demonstrate Their Impact
Digital Science joined forces with Sunmedia, a scholarly information company in Tokyo, to help medical affairs teams across Japan understand their research impact.
UNMC awarded nearly $82.5 million in grants for research, public health programs
UNMC is getting nearly $82.5 million across about 151 grants and other funding allotments from the U.S. health department.
Research report: Digital Science and Sunmedia partner to bring research impact reporting to Japan’s medical affairs teams
Sunmedia will use Dimensions and Altmetric data in customized reports intended to assess attention, sentiment and real-world connections for Japanese medical affairs teams.
Digital Science and Sunmedia Partner to Bring Research Impact Reporting to Japan's Medical Affairs Teams
Digital Science today announced a partnership with Sunmedia to help medical affairs teams across Japan understand the impact of their research.
Customers Kept Asking Vivian Tu for Help. She Turned Their Questions Into a Business
Vivian Tu turned recurring questions from her audience into Ask Dolly, showing how founders can turn customers’ unmet needs into a business.
Joe Manganiello reveals plot of Ben Affleck’s scrapped Batman film
Joe Manganiello shared a detailed plot description for Ben Affleck’s unmade ‘Batman’ movie, which would have seen Deathstroke ‘dismantle Batman’s entire life.’
Scientists find 'gemstones' in atmosphere of bizarre, scorching-hot 'marshmallow' exoplanet
"Planets are temperamental, their atmospheres complex and chaotic."
Business taking action for nature at CBD COP17
At the UN Biodiversity Conference (CBD COP17) in Yerevan, Armenia, from 19-30 October, IUCN will show how business can use science, data and technology to scale up its contribution to the Kunming-Montreal Global Biodiversity Framework.
What Science Changed Its Mind About in 2026
Bats were thought to have fixed, unmoving eyes. Starfish were assumed to feed passively. Queen bumblebees were considered helpless in water. New research in 2026 has quietly dismantled some of science's longest-standing assumptions about the animal kingdom.
LeBron James Believes the Miami Heat are 'Damn Good'
The NBA's oldest superstar breaks down why the Miami Heat's elite defense and revamped floor spacing, led by Giannis Antetokounmpo and Erik Spoelstra, make them legitimate Eastern Conference contenders.
Miami Heat Stars Rated Lower Than Expected In Defensive Rankings
Despite forming a terrifying new frontcourt tandem, Miami Heat stars Giannis Antetokounmpo and Bam Adebayo are both surprisingly low in the latest defensive player rankings, sparking debate over the league's most versatile defensive duo.
A Major Labor Boom in CNY? Not Here Yet
With so many major projects going on — Micron, I-81 viaduct and others — job growth is predicted to increase. But so far the number of jobs in the region has declined By Aaron Gifford [caption id=attachment_11065 align=alignright width=350] Amy Stage, deputy director at the Manufacturers Association of Central New York (MACNY): “For us, the conversation isn’t just about filling jobs. It’s about creating sustainable pathways that help people see a future for themselves in manufacturing.”[/caption] The I-81 viaduct project in Syracuse and Micron facility construction in Clay are expected to create a major labor boom for Central New York. But for the time being, the number of jobs here has actually decreased in the past year. The New York State Department of Labor reported that, for the annual comparison of June 2025 to this past June, private sector jobs decreased by 2,200 or less than 1% to 260,000. Job gains were concentrated in leisure and hospitality (+700), private education and health services (+400) and other services (+300). Job losses for that annual period were reported in the areas of trade, transportation and utilities (-1,500); professional and business services (-1,000); financial activities (-500); mining, logging and construction (-300); manufacturing (-200); and information (-100). The public sector job count rose over 12 months, with most growth concentrated in education, the state Department of Labor reported. Looking ahead, the Central New York economy is expected to benefit from both the Micron and I-81 viaduct projects over a period of several years. Initial job growth is foreseen in construction and computer and electronic manufacturing. Spin-off jobs will be created in the areas of professional and business services, health care and education, the state Department of Labor said in an email response to Oswego County Business magazine. “Population growth tied to the buildout of Micron Technology semiconductor complex in Clay is also expected to bring more workers and residents to the region, increasing demand for transportation services,” the agency said. New York Department of Labor highlighted current or projected job growth trends in various sectors. An increase in defense-related contracts at local high-tech employers has continued to support employment growth in the computer and electronic product manufacturing sector and Micron is expected to generate thousands of direct and indirect jobs as the project progresses. This sector paid an annual average wage of $117,500 in 2025 and employment in the sector is projected to grow by over 60% through 2032, making it the fastest-growing industry in the region. Typical occupations in this industry include electrical, electronic and electromechanical assemblers, software developers and industrial engineers, the state agency reported. Specialty trade contractors include several different types of tradespeople — electricians, plumbers, pipefitters and steamfitters and HVAC (heating, ventilation and air conditioning) mechanics and installers. Many of these positions are trained through apprenticeships, the state Department of Labor reported. The Interstate 81 construction project is generating local jobs, including construction laborers, projected to grow at a 6.4% rate, and operating engineers and other construction equipment operators, projected to grow at a 7.3% rate over the next several years. Construction of the Micron Technology facility is also “creating thousands of job opportunities that will continue over the next two decades,” the state agency reported. The specialty trade contractors sector paid an annual average wage of $86,200 in 2025. For Central New York, the challenge isn’t creating jobs, it’s filling them. Amy Stage, a deputy director at the Manufacturers Association of Central New York (MACNY), said meeting this unprecedented growth is a much larger task than just replacing retirees. “We’re seeing workforce gaps at every experience level,” she said. “Companies need entry-level employees, experienced technicians, supervisors, engineers and skilled trades professionals. The opportunity is tremendous, but we need more people entering these career pathways.” Employers are looking for people who can troubleshoot, read technical information, use computers and learn new processes, not just perform repetitive production work, Stage said. To address this demand, the MACNY created the Manufacturers Talent Institute, which aims to connect students and job seekers with meaningful career pathways while helping employers build their workforce. Twenty-one companies have so far signed up to provide opportunities for more than 800 students. “For us, the conversation isn’t just about filling jobs,” Stage said. “It’s about creating sustainable pathways that help people see a future for themselves in manufacturing.” Several manufacturing facilities in the region are in the midst of expansion: • TTM Technologies, a leading U.S. manufacturer of advanced electronics and interconnect solutions for aerospace, defense and high-technology markets, which has a plant in DeWitt, completed its buildout of an additional facility, adding 400 jobs and expanding production of high-tech circuit boards for defense and critical electronics applications. • In Cortlandville, the Byrne Hollow Crossing Plant, a dairy manufacturing and processing facility, is increasing its operations, creating 100 new jobs. • The Chobani yogurt company is building a 1.4-million square foot dairy processing facility in Oneida County. This will create more than 1,000 good-paying jobs and double Chobani’s New York state workforce, Stage said. Stage noted several ways that local, state and federal governments can help spur manufacturing job growth in this region. Elected leaders and public agencies could work with industry representatives to create pre-apprenticeship and registered apprenticeship programs seeking to upskill workers and improve employee retention. New York state has a variety of grants, tax incentives and financing programs to support site preparation, infrastructure, workforce development and capital investment. The U.S. Department of Labor has a pay-for-performance incentive program that provides employers $3,500 per new apprentice hired and retained for 90 days. MACNY was previously awarded an $87,000 federal grant that will cover 25 apprentices at nine companies. The manufacturing skills gap in the United States, at its current rate, could result in 2.1 million unfilled jobs by 2030, according to a study by Deloitte and The Manufacturing Institute. In New York state, that gap is on pace to exceed 100,000 unfilled positions within six years. Manufacturing companies will be counting on more women to help fill that gap. While women make up half of the overall U.S. workforce, they only account for 29% of the manufacturing workforce in this country, Stage said. “Pre-apprenticeship programs like Real Life Rosies help to bring awareness to the manufacturing industry to fill some of the gaps, but we have a long way to go and it starts with educating people at younger ages about careers in manufacturing and earn-and-learn opportunities,” she said. As for Micron, that $100 billion-plus project, considered the largest private investment in New York state history, is expected to eventually create up to 50,000 jobs throughout the region, factoring in the spin-off opportunities for construction and supply chains. The plant’s foundation was poured on July 9. “As America celebrates its 250th anniversary, data and memory are foundational to the modern economy — and Micron is increasing our U.S. investments to more than $250 billion through 2035 to meet that moment,” the company’s president and CEO, Sanjay Mehrotra, said in a news release. Bechtel, Micon’s construction partner in the project, reported that 4,500 people will be employed to help build the facility, including skilled craft professionals, local union members representing various trades and apprentices. The Syracuse-based CenterState CEO organization tallies the regional labor force at 397,582 workers (Onondaga, Cayuga, Cortland, Madison and Oswego counties). Job growth isn’t limited to the Central New York region. For the larger area covering portions of the Mohawk Valley, the North Country, the Southern tier, and the western part of the state, there are 155,601 employees in the advanced manufacturing sector, and 155,275 construction workers. The agency’s 2026 Economic Forecast report noted that 41% of community and business leaders surveyed said a shortage of skilled workers in this area remains a problem, though 77% shared a positive economic outlook for the year ahead. Beyond the semiconductor and advanced manufacturing areas, local business leaders also see growth in small manufacturing companies, storage businesses, housing, unmanned flight technology and general construction. “Productive reuse of property,” the report said, “will hopefully continue to preserve unique architecture while driving business.” The report identified several challenges for economic growth in the region, including an aging workforce, outdated equipment, the rising cost of raw materials and “the disconnect between the speed of business needs and the pace of talent readiness.”
In fiscal 2026, customers bought 466 vehicle energy storage systems from Scage.
Six-month orders carried about RMB 26.86 million in contract value; certain Nasdaq requirements remain unmet, with one compliance period running to Feb. 23, 2027.
Opinion: Deb Haaland for governor on New Mexico health care
A UNM resident physician urges voters to support Deb Haaland’s plans for health coverage and more doctors.
Erie police say mental health may be factor in shooting that killed 9
Erie police are investigating mental health issues as they look for a motive in the mass killing in which a 45-year-old suspected gunman killed nine people, eight of whom were related, before killing himself at a residence on Perry Street on Oct. 9.
Erie police say mental health may be factor in shooting that killed 9
Erie Police Chief Rick Lorah said investigators believe gunman killed six people inside house before killing two women outside and then killing self.
This 345-Million-Year-Old Fossil Fooled Scientists for Decades
A famous Scottish fossil is forcing scientists to rethink what claw-like feet really reveal about the move onto land. Pressed flat inside two slabs of Scottish rock, a 345-million-year-old skeleton seemed to carry some unmistakable signs of life on land. Its four limbs ended in five-digit feet, and the tips of its fingers and toes
12 reactions · 3 comments | A politician allegedly killed for...
A politician allegedly killed for promoting health measures in the fight against Ebola. Health workers attacked, medical facilities put on fire. What's behind people's anger in response to aid in the...
As Heat adjustment process continues for Giannis, the preseason results have been encouraging
The preseason results have been encouraging, but Giannis Antetokounmpo says he’s still finding his footing with the Heat.
Mental health expert: Seek support when daily life becomes unmanageable
Gateway Community Service Board official discusses resources ahead of World Mental Health Day
GA-ASI Recognizes Three Small Business Suppliers for Quality Performance
General Atomics Aeronautical Systems, Inc. (GA-ASI) has launched a new annual Supplier Quality Recognition program intended to recognize small businesses...
UNM College of Pharmacy to Offer Free Health Services
Community Outreach Day brings flu vaccines, health screenings and education to multiple Albuquerque locations on October 16
Giannis Antetokounmpo: 'I got five, six good years'
Giannis Antetokounmpo: 'I got five, six good years'
3 Questions For Rockets Preseason Opener In Macao
NBA preseason is already underway. Likely MVP candidate Giannis Antetokounmpo has made his unofficial debut for the Miami Heat. Houston Rockets fans will have to wait until Friday, October 9th for their team to play the Dallas Mavericks in Macao. Here are three questions they should look out for when that time comes. 3 Questions …
Miami Heat to play as Vice City from 'Grand Theft Auto VI' for single game, with new court and uniforms
This will also happen to be Giannis Antetokounmpo's first game against his old team, the Milwaukee Bucks.
Is Miami Heat's Andrew Wiggins Due For A Big Season?
After a blockbuster offseason headlined by Giannis Antetokounmpo, the rejuvenated veteran wing could quietly be the X-factor in Miami.
Gunman Kills 2 Co-Workers at Virginia Rental Business
A 37-year-old man shot three employees at an equipment rental business, then killed himself after a standoff with the police, the authorities said.
Unmasked: Guess the NBA player to quiz your sports trivia knowledge (September 30)
60 seconds. 5 clues. 1 player. Test your ball knowledge with today's Unmasked quiz.
Magnetism may have helped kick-start our solar system
Ancient meteorites reveal a powerful magnetic field that may have helped feed the growing sun.
Can Giannis Antetokounmpo Snap a Miami Heat Superstar Trend?
History shows the Miami Heat's blockbuster acquisitions often face first-year hurdles. Now, the Greek Freak aims to defy tradition and navigate a loaded Eastern Conference to secure an immediate title.
Dan Dickman’s legacy takes center stage at 2026 Business Appreciation Luncheon
Dan Dickman's influence was unmistakeable at the 2026 Business Appreciation Luncheon. Many remembered Dickman as a mentor, advocate and community leader who helped people see a path forward when they could not see one themselves.
Georgia Institute of Technology professor Munmun De Choudhury discusses AI, mental health and humanity
On Wednesday evening, students, faculty and community members gathered in Mills Hall to hear Munmun De Choudhury, a computer scientist, social scientist and professor of interactive computing at the Georgia Institute of Technology, speak as part of the Hastings Initiative lecture series. De Choudhury’s research focuses on digital mental health and the effects of emerging […]
Republican coordinated campaign spending surges after US Supreme Court ruling
The Republican committees supporting the party's candidates have exceeded the former national caps by more than $48 million
Target 'Pokémon' Event Quietly Meant To Stop Adults From Buying All The Cards From Kids
Target's special 30th Anniversary Pokémon event will give out a promo card, goodie bag, and plenty of TCG products
Jewel Reveals How She Teaches Her Teenage Son About ‘Mental Health Hygiene’
Jewel, 52, knows firsthand what happens when a child’s emotional needs go unmet, and she’s determined to give her own son a different experience. Having lived through a chaotic childhood that included...
Situation Report No.11: Earthquakes in Venezuela 2026 (M7.2 and M7.5)
Nearly three months after the 24 June 2026 earthquakes in Venezuela, the response has moved into early recovery while sustaining essential emergency operations. Efforts now center on maintaining continuity of care across mental health, sexual and reproductive health, maternal and neonatal care, NCDs, and rehabilitation, alongside restoring affected facilities, supporting transitional camps, and strengthening Health Cluster coordination as Emergency Medical Teams and international partners withdraw. Health system recovery is advancing, with 16 ASICs and 356 health facilities assessed (61% operational) and rehabilitation progressing under CERF, CFE and US funding, while fluctuating electricity, medication refrigeration and emergency-generator gaps continue to challenge the safe continuity of essential health services. Public health surveillance and prevention remain active, with 47,145 cumulative vaccine doses administered and 556 health professionals trained, while intensified surveillance in La Guaira and Miranda and mounting environmental risks from tropical rains and heatwaves continue to require sustained vector-control and water/sanitation action. Contraception remains the most consistent unmet need across assessed shelters, particularly among adolescents and young women, while mental health needs continue to rise across the transitional camps amid limited supplies and specialized personnel. PAHO/WHO continues to support the response with critically needed medical supplies and medicines, having shipped 46.6 metric tons to Venezuela to date, benefiting 72 actors and reaching 117,714 people with treatment through PAHO and partner donations, while sustained technical and logistical support to the Ministry of Popular Power for Health (MPPS) has strengthened the national supply chain and ensured the continuity of health services through the coordination, reception, and mobilization of international donations of essential medical products.
How lip-syncing to AI let Forced Entertainment ‘play the game of theatre’
Today we have a fascinating piece by long-time Forced Entertainment fan Ben Kulvichit, speaking to Tim Etchells about their latest show Cold Sweat, how they are integrating lip-sync and AI voices into their work, the question of ‘authenticity’ on stage, and how lip-sync has even opened the door for them to make “something a little bit like drama”. This piece is a paid partnership with the Southbank Centre, where you can see Cold Sweat next month – we’re very grateful to the Southbank Centre for their ongoing support for Exeunt. Holly Williams ‘It was immediately interesting and uncanny’ **By Ben Kulvichit** “Is the microphone on?” So goes one of the opening lines of Signal to Noise, delivered by a human performer lip-syncing to an AI-generated voice. The voice is American, cheery but sluggish, slowed down into a gelatinous drawl. It repeats ad infinitum in a farce of stuckness; an answer never materialises. I find myself asking the same question as I hop on a Google Meet call with Tim Etchells, the artistic director of Forced Entertainment. We spend five or ten minutes frowning at each other, muting and unmuting, me gesticulating in semaphore into my webcam, checking if I am coming through now, restarting the laptop. To Etchells, I appear exaggeratedly mouthing words, my voice missing. In this gloopy purgatory of broken communication, life imitates art imitates life imitates art. We try a Zoom instead. Forced Entertainment, the pioneering British theatre company who have been at the avant-garde of performance since the 1980s, turned an interesting artistic corner with Signal to Noise, created on the occasion of their 40th anniversary. The whole performance employed this lip-sync technique to AI voices; on the face of it a left-field move from a company whose identity has long been grounded in the earthy, immediate presences of its performers and its unassuming, low-tech approach to theatricality. The technique, however, turned out to provide the company with a “rich new seam” of artistic enquiry, and has now spawned a trilogy of works. The second instalment, Cold Sweat, plays at Sheffield Theatres, Southbank Centre, and Lancaster Arts in October, while the third part, Everything Must Go, has been touring in Europe and is slated to come to the UK in 2027. As is often the case with Forced Entertainment shows, the main conceit for this work didn’t arrive until quite late. They were “four or five weeks into rehearsals for Signal to Noise,” Etchells recalls, and getting nowhere. Away from rehearsals, he had been playing around with feeding “weird texts” to AI voices to see how they would cope with them – “basically for my own amusement” – and was compelled by the uniformly “serviceable, benign, good-natured” tone they would read in, no matter how poetic, fractured or experimental the writing. On a hunch, he brought some examples into rehearsals and the performers gave lip-syncing a go. “It was immediately interesting and uncanny,” he recalls, with the performers having to deal in the moment with the problem of mapping themselves onto another artificial ‘performer,’ which itself was dealing with the problem of a very human text. “Almost all the writing for these projects would be useless to us unless it was done in this way,” says Etchells. “We wouldn’t know what to do with it. It’s too poetic. It’s too fictional. It’s too tangled.” But exploring lip-syncing along to the text has opened “an enormous reservoir of ways of thinking about writing and performing.” Subscribe to Exeunt, and get two in-depth pieces on theatre a week, direct to your inbox Subscribe Forced Entertainment have long been sifting through the detritus of popular culture, from daytime TV to end-of-the-pier vaudeville, magic acts and clown shows, to find frameworks for their own unusual entertainments. Lip-syncing, then, makes sense for them to experiment with. As a mode of performance, it’s wired into popular consciousness through pop stars trying to convince stadium audiences of their liveness, or those same voices as channeled through the made-up lips of contestants on RuPaul’s Drag Race, or movie dialogue spreading virally through the host bodies of TikTok users. For Etchells, lip-syncing is often about “approaching real voices and trying to take on their aura,” subsuming that original human presence into yours. “There’s a very basic, elemental sort of theatre magic to it, produced in this very easy way.” This broad approach resonates with instances of lip-syncing within contemporary performance, too. In works like Re-Member Me and Showmanism, performance artist Dickie Beau acts as a kind of spirit medium for archival recordings (this process of re-membering – as in, giving corporeal form to voices – relies on his masterfully precise actor’s technique), while Frankie Thompson is similarly possessed by a host of characters ranging from a nine-year-old Jacob Rees-Mogg to Cliff Richards, all of whom she finds compellingly nauseating, in the exorcism ritual that is her latest show, Horrible Things. What’s different about Forced Entertainment’s use of lip-syncing is that here, there is no original presence to be channeled. The performers are instead taking on what Etchells describes as “the voices of nobody,” or rather the “phantasmic, aggregated echoes” of the many many voices on whose data the AI has been trained, and which are now conjuring into existence words they never actually said. There is a sort of mournful, empty quality to these voices, having “washed up” far away from the people they originally belonged to, to find themselves in stranger’s mouths listing objects, wondering if anyone can hear them and glitching in interminable loops. There is a cold, sad anonymity to it all. Etchells remarks that occasionally the software company he used has notified him that particular people are withdrawing their voices from the platform, instructing him to cease use of those voices. Using these technologies in performance certainly brings up ethical questions around digital rights, consent, identity and ownership, although in the grand scheme of things, Etchells is fairly blasé about it: of all the purposes someone’s voice might be put to without their knowledge, “an avant-garde performance is probably the least of their worries.” [ ](https://exeuntmagazine.substack.com/p/frankie-thompson-horrible-things-essay-mental-health-compulsive-behaviours-pleasance-courtyard-soho-theatre) [ Frankie Thompson: How I manage my own ‘horrible things’ at the Edinburgh Fringe ](https://exeuntmagazine.substack.com/p/frankie-thompson-horrible-things-essay-mental-health-compulsive-behaviours-pleasance-courtyard-soho-theatre) Exeunt · Aug 25 [ Read full story ](https://exeuntmagazine.substack.com/p/frankie-thompson-horrible-things-essay-mental-health-compulsive-behaviours-pleasance-courtyard-soho-theatre) For the performers, though, lip-syncing to these strange, artificial voices is an odd task, requiring them to bend their live, human presence into the shapes produced by machines. Politically, it mirrors processes that are already at play in the continued computational automation of human life. Etchells brings up James Bridle’s writings on new technologies as a reference point: one example Bridle gives is of “chaotic storage”, a logistics technique employed by Amazon fulfilment centres whereby items are stored not according to traditional methods of categorisation or alphabetisation, but in a way that an algorithm determines to produce the most efficient routes for ‘picking’ based on customer purchase patterns. This appears completely random and incomprehensible to humans, with paddling pools sitting next to USB sticks sitting next to blowtorches, and so for the warehouse workers, the process of picking items becomes completely reliant on technology which tells them where to go. Our world is increasingly being designed not with humans in mind, but rather machines. As Etchells puts it, “technology malforms the space, and then you end up having to live in it.” Initially, Forced Entertainment tried their best to live in the world of machines: “I was in the it’s-got-to-be-perfect school of lip-sync,” says Etchells. But with their aesthetic being so tied to the failing act, the slipping mask, the shoddy costume, “it’s no surprise really that that didn’t last.” Instead, the performers got to enjoy being late for a line, or playing games with each other, “stealing” each other’s voices. Etchells compares it to the principles of ventriloquism, in which a free-floating voice unattached to a body is fundamentally discomforting and “sort of traumatic”. That discomfort is equally as alluring to Forced Entertainment as the satisfaction of precision, the pretence of authenticity only interesting if shown to be a pretence. Lip-sync has also opened up new avenues for the company. Having been allergic all their lives to Plays-with-a-capital-P, with Cold Sweat Forced Entertainment find themselves approaching something a little bit like drama. Rather than the presentational arena of Signal to Noise’s open white stage, Cold Sweat places us more decisively in a “fictional locale”: what appears to be “the aftermath of some disastrous party or backyard drinking binge” where three figures – family members, or neighbours, perhaps – are the last ones standing. “It’s all quite acrimonious and accusatory, everyone’s talking over each other.” For Etchells, this more fictional mode is “a door that we’ve never been able to open. We’ve just never really gone there.” Perhaps it is the technique of lip-syncing, an extra buffer of mediation, that allows them to venture away from the here-and-now without feeling that they have to commit to the “psychological claptrap” that comes along with acting; to be able to “play the game of theatre, without getting one’s hands too dirty.” As I wonder how else the impulses behind Forced Entertainment’s work have changed over time, it occurs to me that over the last ten years of new creations, with the exception of If All Else Fails, the company’s performers haven’t ever spoken on stage: there were two shows without any language at all, Out of Order and Under Bright Light, and then this trilogy of lip-sync works. Etchells agrees it’s a shift away from earlier productions, that were so often about “the actual voices of the performers and their actual presences. We had a lot of money, in some ways, on an authentic approach to what it might mean to speak on the stage.” But this sense of authentic presence itself had a fakeness to it; these days, Etchells can’t stand that mode of being onstage where performers “are here to be cheeky and witty versions of themselves. I don’t want to be charmed.” Pulling back into a more anonymous space has resulted in works that feel slightly sharper-edged, more brutal in a way. “All of these shows are post-Brexit, post-Trump, post-truth, post-everything,” Etchells notes. Speech, charisma, authenticity – these things feel politically loaded, and perhaps warmth and openness just don’t feel like the right tools to reflect the world we’re living in. “It feels like the space is closing down, and we’re trying to deal with the fact that the system, the structure that you’re in, is more oppressive and more powerful. It probably always was, but I think we’re just more tuned to it now.” Yet even without their voices, the performers’ distinctive presences – ones that many audiences have followed around for years, if not decades – still, inevitably, shine through as they physically navigate whatever unending task the system of the piece has set for them. They’re still trying to keep up with the onslaught of text, still running about, changing costumes, moving stuff around. The human is always stuck in the teeth of the machine, jamming the smooth, frictionless cheeriness of the not-real, gesticulating silently, trying desperately to communicate. Cold Sweat is at Sheffield Theatres, 2 to 3 October; Southbank Centre, London, 9 to 10 October; Lancaster Arts, 14 October [ ](https://exeuntmagazine.substack.com/p/exeunt-recommends-the-best-autumn-theatre-2026-lives-of-others-standard-of-living-our-friends-in-the-north-lanny-) [ Exeunt recommends... the best autumn theatre ](https://exeuntmagazine.substack.com/p/exeunt-recommends-the-best-autumn-theatre-2026-lives-of-others-standard-of-living-our-friends-in-the-north-lanny-) Exeunt · Sep 16 [ Read full story ](https://exeuntmagazine.substack.com/p/exeunt-recommends-the-best-autumn-theatre-2026-lives-of-others-standard-of-living-our-friends-in-the-north-lanny-) This piece was paid for by the Southbank Centre. Such support helps Exeunt to keep publishing the most interesting writing, about the most exciting theatre. Interested in partnering with Exeunt? Visit our Advertise with Exeunt page, where you can get more information, download an advertising pack, and find our contact details.
Ayo Dosunmu Challenges Andrej Stojakovic to Become an All-American
Illinois legend Ayo Dosunmu has high expectations for Andrej Stojakovic, challenging the Illini star to become an All-American during his senior season.
Halo 3, Mass Effect, BioShock, Rock Band, and More: Fall 2007 Was the Greatest Season in Xbox – and Also Gaming
The fact that you can slice up the Fall of 2007 in so many different ways – best Xbox season ever, best PC season ever, best November ever – and the argument for its unmatched brilliance still holds up is iron-clad proof that it is, indisputably, the best season in video game history.
Masked gunman robs two New Orleans businesses in two days
Police arrested a suspect Saturday but have not said if the two robberies are connected
Baltimore archbishop urges women religious to model renewal of American political culture
"The world needs women who have been seized by Christ. It needs women whose lives bear unmistakable witness to the truth that God is real."
Frontier Restaurant CEO donates $250,000 to UNM business school
Shannon Rainosek’s gift will support internships, competitions, conferences and international travel for UNM students.
Frontier Restaurant CEO donates $250,000 to UNM business school
Shannon Rainosek’s gift will support internships, competitions, conferences and international travel for UNM students.
Davion Mitchell reveals Giannis Antetokounmpo's secret behind his success
Giannis Antetokounmpo is bringing a winning mentality to the Heat, and his teammates are seeing it firsthand.
United Bank hires Phil Poliquin to lead government contracting business
Phil PoliquinUnited Bank, a subsidiary of United Bankshares, Inc. (NASDAQ: UBSI), has announced that Phil Poliquin has joined the Bank as senior vice president and managing director of Government Contracting (GovCon), leading the next phase of growth for United’s GovCon business across the Bank’s footprint.United has a longstanding history of serving government contractors and meeting the dynamic banking needs of companies supporting federal, state and commercial markets. Building on that foundation, the Bank is establishing a dedicated GovCon team led by Poliquin. The new team will bring together bankers from across United's footprint under a focused strategy designed to deepen industry expertise, strengthen client relationships and expand the Bank's presence in this important market.“Government contractors operate in a complex and highly specialized environment, and Phil understands that environment from multiple perspectives,” said United Bank Chief Commercial Lending Officer Mike Proctor in a press release. “His extensive commercial banking experience, combined with more than two decades of military and government service, brings tremendous depth and expertise to our team. We’re excited to have his leadership and insight as we continue strengthening how United serves our GovCon clients across the nation’s capital and beyond.”In his new role, Poliquin will lead United’s GovCon lending strategy and a team of specialists, with a focus on deepening client relationships and expanding the Bank’s presence in the government contracting and defense sectors. He will also serve as a subject matter expert across the organization, partnering with bankers across United’s footprint to support GovCon clients and opportunities.“Government contracting has long been an important part of the economy across the Washington region, and we believe it remains an attractive sector for growth,” said United Chief Executive Officer Richard M. Adams, Jr. in a press release “As the needs of these companies continue to evolve, investing in specialized leadership strengthens our ability to build on our established presence, expand how we serve this market, and pursue new opportunities.”Poliquin has a decade of experience in commercial banking, most recently serving as executive director of Aerospace, Defense, and Government Services (ADG) commercial banking at JPMorgan Chase. In this role, he led a team responsible for providing specialized financing and treasury advice to federal government contractor companies across the nation. Previously, he also held senior leadership positions at Bank of America.Prior to his banking career, Poliquin served 24 years in the U.S. Navy, retiring at the rank of Captain in 2013. A Naval aviator, he flew more than 100 combat missions in operations around the world and served in senior leadership positions, including as commanding officer of an F/A-18 Super Hornet squadron, leading more than 250 personnel during two combat deployments. He later joined the Intelligence Community as a program manager at the National Reconnaissance Office and contributed to the development of the Navy’s unmanned aircraft system strategy.“United has a strong foundation in government contracting, and I’m excited about the opportunity to build on that foundation by expanding our industry presence, deepening relationships, and developing a team with specialized expertise focused on serving government contractors,” said Poliquin in the release. “The goal is to be a trusted resource for growth-oriented companies that need a banking partner who understands what they do, where they’re headed and can help them navigate the opportunities and complexities of this market.”Poliquin holds a bachelor’s degree in mathematics from the University of Oklahoma, a master’s degree in national security strategy from the U.S. Naval War College, and an MBA from the University of North Carolina at Chapel Hill’s Kenan-Flagler Business School.
Why Santa Monica's Local Politics Still Matter
Santa Monica Daily Press columnist examines why local government oversight matters when facing federal threats to the California Coastal Commission and city governance.
'Sinners' star Wunmi Mosaku confirms she quietly welcomed second child
LOS ANGELES — Wunmi Mosaku has confirmed the birth of her second child — with style. The "Sinners" actor posed for photos with her two children, a then-10-week-old son and
'Sinners' star Wunmi Mosaku confirms she quietly welcomed second child
LOS ANGELES — Wunmi Mosaku has confirmed the birth of her second child — with style. The "Sinners" actor posed for photos with her two children, a then-10-week-old son and
In reversal, California regulator says unmarried drivers should not pay more for auto insurance
California Insurance Commissioner Ricardo Lara, in a reversal, will no longer allow auto insurers to consider marital status in setting premiums, a policy that has resulted in unmarried drivers paying more.
STUFF Named 2026 NBA Mascot of the Year
The Orlando Magic’s legendary dragon clinches his third career title, cementing a record-breaking season of high-flying stunts, viral digital content, and unmatched comedic performances across the league.
Breaking Lobos: Ryan Berryman Wants UNM to Define Albuquerque
This is a freelance story submitted by KC Smurthwaite, a consultant with Athletics Admin who specializes in the collegiate athletics space. If you’ve never been to Albuquerque, Ryan Berryman already has a pretty good idea of what might be on your New Mexico scouting report. “Sometimes all they know is they watched Breaking Bad one […]
Ukrainian defence tech seeks new ways to scale up
Since Russia's full-scale invasion in February 2022, Ukraine's defence sector has expanded several-fold, becoming a significant source of military innovation, especially in unmanned systems, counter-drone technologies, electronic warfare and AI-driven combat systems. But finding the funds and personnel to scale up and to reach international markets remains a challenge.Spurred on by the demands of the front-line, Ukrainian defence companies say they can develop a minor component in a couple of weeks, or major hardware or software solutions within a year. This is several times faster than the usual development cycles in the sector. Tencore, founded in 2024, is now one of Ukraine’s largest providers of unmanned ground vehicles, well exceeding the production of NATO members in this category. Odd Systems, a Ukrainian combat cameras developer founded in 2023, launched its first thermal camera in 2024. Less than two years later, it is developing the fourth generation of the product, one that has evolved into a full vision system.According to Michael Singer, managing partner at Verne Capital, a venture capital fund supporting defence companies in Europe, this speed is down to the short feedback loop between the developer and the end user. “Ukrainian companies develop technologies in close interaction with soldiers and military units, test them under real combat conditions and rapidly incorporate feedback into the next generation of the product,” he says. “Sometimes we need to react to feedback and deploy an upgrade within hours,” says Polina Tymchenko, the spokesperson for Himera, which develops electronic warfare-resistant walkie-talkies. “It means that, as a company, you have to have a higher tolerance for risk, and also design your products in a way that fosters those quick changes.”Getting a product deployed by a combat command involves no paperwork other than a purchase order, says Perry Boyle, co-founder and chief executive of Mits Capital, a Ukrainian-US investment group focused on attracting capital for Ukraine's defence tech sector. “New weapons can be developed and deployed based largely on handshakes.”Nevertheless, the speed of development is largely subject to the level of funding, says Iryna Sukhomlyn, head of business development at RMachine, a developer of unmanned ground systems. “Financial support needs to start much earlier, particularly at technology readiness level 3-5, not only when most of the technological risk has already been removed,” she says.In 2025, Ukrainian defence tech companies attracted about $129 million in investment, with the true figure likely higher given the share of undisclosed security-sensitive deals, according to a report published by the Kyiv School of Economics. These investments were primarily concentrated in the AI and software segment, as they are considered a lower financial risk.Scaling production is a major barrierAccording to Iryna Supruniuk, business development director at Odd Systems, proving a defence product in Ukraine is not the end of the development process, but the beginning of a continuous evolution, since operational requirements change rapidly. “Continuous iteration remains our highest priority,” she says.It's also when production must scale up, which represents a major hurdle. “Scaling production requires capital, manufacturing capacity, components, certification, procurement access and reliable supply chains,” Singer says. Scale-up is also hampered by demographic pressures, especially a shortage of young specialists needed to expand engineering teams. Companies have reported struggling to replace specialists lost due to Russian attacks, mobilisation and emigration. In order to meet this scale-up challenge and finance arms production, begun allowing defence technologies to be exported, assuming it has an excess capacity. It has also announced the creation of ten defence and weapons export centres across Europe by the end of 2026.According to Singer, a technology that has demonstrated its value under real combat conditions has a fundamentally different credibility than a product that has only been tested in a laboratory or training environment. But combat validation alone doesn’t automatically create an international business. “Companies still need access to foreign defence ministries and procurement organisations, international certification, financing for production scale-up and, in many cases, local industrial partners,” he says.Already in 2026, the EU has signed several agreements with Ukraine that aim at joint defence technology development and production. These include allowing Ukraine to join the European Defence Fund, signing a financing agreement under the European Defence Industry Programme, and setting up the EU-Ukraine Drone Alliance.For Singer, it is important that European defence companies don’t just see their Ukrainian partners as technology suppliers, but rather as potential innovation partners. “Ukrainian companies bring speed, operational experience and an exceptional ability to iterate. European partners can provide industrial capacity, capital, established supply chains and access to European procurement markets.”Procurement possibilitiesWhen it comes to exports, the procurement and compliance processes involved require time, taking months or even years, and money. In other words, resources that small defence tech companies need if they are to improve and scale up their technologies. According to Sukhomlyn of RMachine, if the priority is to rapidly increase available defence capabilities, then the processes need to reflect that urgency. “If Europe wants defence innovation at wartime speed, its administrative processes also need to operate much closer to wartime speed,” she says, highlighting a need for support with certification, market access and mutual recognition of relevant testing. “Otherwise, we risk having excellent technology available but spending years making it administratively eligible to be purchased.”Related articlesRussia widens targeting of European research centresEU must support research managers in central and eastern Europe, says Visegrad fund headThis is a lesson Europe’s defence sector would do well to learn, Singer says. “Defence innovation needs to be organised around the speed and requirements of the end user, not around the speed of the bureaucracy.”Supruniuk says the European defence sector should rethink the balance between quality and quantity. “In many cases, a good-enough system available in thousands of units creates greater operational value than a perfect system available in dozens.”“For decades, everyone has been looking for that all-powerful, exquisite system that can protect everyone,” adds Tymchenko. “We see in crime that only scalable, dedicated, affordable solutions can actually defend democracies.”
Beyond hot flashes: A whole-health approach to menopause
For the average woman, life after menopause spans decades – and what she needs to stay healthy may change considerably along the way. That long view is one reason this year’s Menopause Unmasked event will bring several areas of expertise into the conversation. The community panel, presented by LMH Health and Lawrence Public Library on Sept. 29, […]
Ranking Bucks' Position Groups for 2026-27 NBA Season
Milwaukee's first season after the Giannis Antetokounmpo trade will lean on a deep guard room, a crowded center rotation and a forward group full of question marks.
NORWEGIAN CRUISE LINE® UNVEILS SHOW-STOPPING ENTERTAINMENT LINEUP ABOARD NORWEGIAN AURA™ WITH "WHITNEY: A CELEBRATION OF WHITNEY HOUSTON" TAKING CENTER STAGE
- The New Original Production, Developed with The Estate of Whitney E. Houston and Primary Wave Music, Celebrates the Unmistakable Voice, Music and Legacy of...
Findings in Science Reported from Sun Yat-Sen University (Long-term care insurance and unmet needs in China: perspectives of older adults and family members): Science
According to news reporting originating from Guangzhou, People’ s Republic of China, by NewsRx correspondents, research stated,“ With population aging, many countries have introduced long-term care insurance and provide home-based services for older adults. For more information on this research see: Long-term care insurance and unmet needs in China:...
'A Long Winter' review: Fred Hechinger fronts a beautiful, unmissable queer drama
"All of Us Strangers" writer/director Andrew Haigh is back, with Kit Connor, Ebon Moss-Bachrach, and Caitríona Balfe.
Freya Industries raises SEK 6M to expand drone detection business
Swedish drone detection company Freya Industries has closed a SEK 6 million (approx. EUR 500k) round that will fund orders and expansion through Europe. Foundry ventures, Longswan Ventures, Propel Capital, Saminvest AB (via Annexstruktur), Schyssta Änglar, Sting and a small group of private investors contributed to the round. Freya’s sensors are designed to detect drones
Crystal Palace 2-3 Ipswich
Followed by poor defending, leaving players unmarked in the box, it was too easy for Ipswich to score. However, we made it hard for ourselves by not wrapping up the game with the five or six chances we had early in the second half when we continued to dominate.
Popular young rapper dead at 22 after being ambushed by six gunmen. Here’s the latest
More than 50 shots were fired in the incident.
Detroit Tigers Long for Someone Like Todd Jones Again
As Detroit’s bullpen struggles to close the door in 2026, we revisit the dominant, mustachioed reign of franchise saves leader Todd Jones and his unmatched ninth-inning reliability.
UNMC’s Saxena Health Center to Display Chihuly Sculpture Formerly at Joslyn
Crews will install a recognizable sculpture by world-renowned glass artist Dale Chihuly inside the Nebraska Medicine Saxena Health Center, currently under construction on the southeast corner of 42nd & Farnam street. The piece, “Dale Chihuly: Inside & Out,” will be visible through the 3-story glass-enclosed lobby on the building’s northwest corner. It was previously on […]
Former NBA Champion Discredits New Miami Heat's Giannis Antetokounmpo Skills
Channing Frye sparks debate by labeling the multi-time MVP a physical "running back" lacking technical finesse, reigniting the rivalry between pure athleticism and versatile shot-making dominance.
Ayo Dosunmu’s Goal to Improve Should Excite Timberwolves Fans
Ayo Dosunmu is ready to step it up..
Should The Miami Heat Pursue Darius Garland?
Following the blockbuster addition of Giannis Antetokounmpo, Miami could target Darius Garland to fix backcourt depth issues and solidify a championship-caliber big three.
Three Pressing Questions Bucks Will Have to Answer This Season
A new coach and an overhauled roster leave the Bucks searching for their identity in the first season after Giannis Antetokounmpo.
David Petraeus: George W. Bush, Political Courage, and the Surge in Iraq
In the wake of the September 11 attacks, President George W. Bush launched what he called the War on Terror. It began with the invasion of Afghanistan in late 2001, which quickly toppled the Taliban and expelled al-Qaeda from its most crucial sanctuary. Then, in early 2003, American forces—with the support of foreign allies like the United Kingdom, Australia, and Poland—attacked Iraq, toppling Saddam Hussein’s regime and installing an occupation force in hopes of quickly transforming the country into a free and democratic state. Instead, the post-regime coalition authority made significant missteps, and a devastating insurgency erupted. And despite President Bush’s 2004 reelection, the war quickly lost popular support among the American public. In early 2007, Bush appointed General David Petraeus, who had already served in Iraq as a two- and three-star general, to lead allied forces in Iraq, which heralded a sea change in American strategy known as “the surge.” As part of our coverage looking back on 9/11 and the world it created, General Petraeus tells the inside story of one of the most consequential moments in the War on Terror. The general’s essay today is both a crucial history and a profile in political courage. It demands reflection as we take stock of the last 25 years. —The Editors By the end of 2006, the war in Iraq was failing. There is no useful purpose in softening that judgment with the passage of time. The bombing of the al-Askari mosque in Samarra by terrorists that February had accelerated sectarian violence and pulled Iraq into an increasingly vicious Sunni-Shia civil war. Al-Qaeda in Iraq and Sunni insurgent groups controlled substantial areas, Shi’ite militias operated with growing impunity in other parts of the country, and the Iraqi security forces were no longer capable of arresting the downward spiral. The strategy of transitioning security responsibilities to Iraqi forces, consolidating American troops on large bases, and progressively reducing the U.S. presence had clearly been invalidated by the escalating violence. The numbers conveyed the horror imperfectly but unmistakably. In December 2006, an average of 53 Iraqi civilians were killed by violence every 24 hours in Baghdad alone. Washington, meanwhile, was approaching its own breaking point. Public support for the war had fallen dramatically, President George W. Bush’s Republican Party had just lost control of both houses of Congress, and the bipartisan Iraq Study Group—of which future defense secretary Robert Gates was a member—had recommended a course that anticipated a substantially reduced American combat role. Many senior military leaders were deeply skeptical of sending substantial additional forces, advocating instead for an accelerated transition to Iraqi forces, the deployment of additional trainers and advisers, or other more modest measures with an eye to withdrawing U.S. forces. Virtually every political incentive pointed toward reducing America’s commitment. President Bush chose instead to increase it, a decision that remains, in my view, one of the most courageous presidential decisions of the 21st century.
Looking to address workforce shortages, Nichols launches flexible mental health counseling masters program
The new master’s program comes as Massachusetts faces both high unmet behavioral-health needs and staffing instability in outpatient care.
UNM Boosts Quantum Science & Tech Education
As New Mexico makes significant investments to establish itself as a leader in quantum technology, The University of New Mexico is expanding its
UNM expands academic commitment to quantum information science, engineering and technology
As New Mexico makes significant investments to establish itself as a leader in quantum technology, The University of New Mexico is expanding its academic efforts to prepare students for the opportunities emerging alongside this growing industry and new...
ACC releases men’s basketball schedule
CHARLOTTE, N.C. (TheACC.com) – The Atlantic Coast Conference today announced its 2026-27 men’s basketball conference schedule. The regular season tips off on Sunday, November 1, while conference play begins on Tuesday, December 29 and runs through Saturday, March 6. “ACC Men’s Basketball has an unmatched tradition, and we are excited for another season of compelling matchups […]
JYP Entertainment aims to unmask anonymous Stray Kids bootlegger
South Korean music firm JYP Entertainment is turning detective to uncover the anonymous bootlegger who uploaded a new track by a member of Stray Kids to streaming services under a different name.
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
LOS ANGELES (AP) — The mother of Caleb Vazquez alleges in her lawsuit that Park Mental Health Treatment of San Diego failed to intervene despite signs that her 18-year-old son posed an imminent threat to himself and others.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Giannis Antetokounmpo and Others Defend T.J. McConnell in Major Debate
Miami Heat star Giannis Antetokounmpo and other players around the league defended Indiana Pacers guard T.J. McConnell in a major debate.
'Down to a science': Labor Day barbecue goes off without a hitch
WHATELY — Strolling through the Whately Congregational Church’s parking lot around noon on Monday brought to life the unmistakable aroma of boiled corn. But this was just a hint of what was going on inside. Parishioners once again rolled up their sleeves on Labor Day to dole out purchased meals of a barbecued half-chicken, fresh […]
Former Miami Heat Forward Approves Klay Thompson Signing
NBA veteran PJ Tucker breaks down why the sharpshooter’s elite floor-spacing is the perfect ingredient to unlock the Miami Heat's offense alongside stars Giannis Antetokounmpo and Bam Adebayo.
Panthers fans unmoved by 3-1 preseason record
Panthers fans wary of success heading into regular season
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
Caleb Vazquez and another teenager killed three people at a San Diego mosque before taking their own lives.
Who Are More Candidates For Miami Heat's Final Roster Spot?
After landing Giannis Antetokounmpo this offseason, the Miami Heat have put together a strong bench unit. With their final roster spot, which veterans should the team target?
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
Just days before two teenagers carried out a mass shooting at a San Diego mosque, federal law enforcement officials warned the parents of one of the shooters that their son was making concerning comments about school shootings on the dark web, according to new details included in a recently filed lawsuit.
Reader views on Albuquerque police, New Mexico politics and local issues
Letters address APD DWI concerns, the governor’s race, taxes, oil revenue and UNM athletics fees.
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
LOS ANGELES (AP) — Just days before two teenagers carried out a mass shooting at a San Diego mosque, federal law enforcement officials warned the parents of one of the shooters that their son was making concerning comments about school shootings on the dark web, according to new details included in a recently filed lawsuit. […]
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
The parents of Caleb Vazquez are suing Park Mental Health Treatment of San Diego, claiming it did not act on FBI warnings about their son’s online activities relating to school shootings. The facility disputes responsibility for the teenager’s actions.
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
Federal law enforcement warned the parents of Caleb Vazquez, one of two teenagers involved in a San Diego mosque shooting, about his concerning online comments days before the attack
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
LOS ANGELES (AP) — Just days before two teenagers carried out a mass shooting at a San Diego mosque, federal law enforcement officials warned the parents of one of the shooters that their son was making concerning comments about school shootings on the dark web, according to new details included ...
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
Federal law enforcement warned the parents of Caleb Vazquez, one of two teenagers involved in a San Diego mosque shooting, about his concerning online comments days before the attack.
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
Federal law enforcement warned the parents of Caleb Vazquez, one of two teenagers involved in a San Diego mosque shooting, about his concerning online comments days before the attack. The
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
LOS ANGELES (AP) — Just days before two teenagers carried out a mass shooting at a San Diego mosque, federal law enforcement officials warned the parents of one of the shooters that their son was making concerning comments about school shootings on the dark web, according to new details included in a recently filed lawsuit.
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
LOS ANGELES (AP) — Just days before two teenagers carried out a mass shooting at a San Diego mosque, federal law enforcement officials warned the parents of one of the shooters that their son was m…
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
Federal law enforcement warned the parents of Caleb Vazquez, one of two teenagers involved in a San Diego mosque shooting, about his concerning online comments days before the attack.
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
Federal law enforcement warned the parents of Caleb Vazquez, one of two teenagers involved in a San Diego mosque shooting, about his concerning online comments days before the attack.
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
Federal law enforcement warned the parents of Caleb Vazquez, one of two teenagers involved in a San Diego mosque shooting, about his concerning online comments days before the attack.
When Will Miami Heat Extend Giannis Antetokounmpo?
After sacrificing their young core for Giannis Antetokounmpo, Pat Riley and the Miami Heat front office must now navigate strict league restrictions to secure the superstar’s long-term future.