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Suspect arrested in Texas for fatal stabbing outside downtown Las Vegas business
A suspect has been arrested in connection with the fatal stabbing of a man outside a business in downtown Las Vegas on September.Las Vegas Metropolitan Police D
The 10 scariest defenses in high school football this season
From Santa Margarita to Buford, these 10 high school football defenses are terrifying opponents with shutouts, stingy stats and championship hopes.
Ohio man at center of political storm in Alaska
Jerid Kurtz won attention for his work in Obama and Brown campaigns. He's under fire now for involvement in Alaska race.
The Science Of Sharing: Why Generosity Matters
As the leaves change across Severna Park and we gather with family around Thanksgiving, November naturally invites us to reflect on gratitude.
Georgia’s Connor Tomlinson goes beyond ‘Love on the Spectrum’ with new girlfriend
Breakout star, and Cumming resident, Connor Tomlinson has left "Love on the Spectrum." But he has a new podcast, "What the Fact," and found love again, this time "naturally."
A peek inside the 2026 L’Oréal-UNESCO For Women in Science celebration
Vox and L’Oreal Groupe celebrate this year’s grant recipients.
Three Rivers Report: How Cleveland will defend Pittsburgh on Sunday
Steelers news, notes, and more from October 29.
Coastal Carolina Fair returns for 69th year with rides, live entertainment, games and food
The 69th annual Coastal Carolina Fair runs Oct. 29-Nov. 8 in Ladson, featuring amusement rides, live entertainment, games and food.
Digital Science acquires AI research and writing platform Jenni AI
Acquisition to connect Jenni AI with Digital Science’s research data, beginning with Dimensions and its database of 171 million publications
Ria Health Brings 24/7 Peer Support to Virtual Alcohol Treatment Through Partnership with CHESS Health
Patients in all 50 states now have round-the-clock access to peers, community and crisis support through the Connections app, extending care far beyond the scheduled visitSan Francisco, CA, Oct. 29, 2026 (GLOBE NEWSWIRE) -- Cravings, stress and isolation don’t keep office hours. Ria Health, the nationwide telehealth provider of alcohol use disorder treatment, is making sure its patients never face those moments alone. Through a new partnership with CHESS Health, every Ria Health patient now has
Greg Hinz: The Bears stadium deal is suddenly looking real. Here’s why.
The Chicago Bears appear closer than ever to a stadium deal in Illinois. Greg Hinz explains why Pat Ryan, Roger Goodell and JB Pritzker are key.
Trump administration kills science ed program named for Lou Stokes; Rep. Shontel Brown appeals
U.S. Rep. Shontel Brown wants the Justice Department to provide the evidence it used to support canceling several National Science Foundation programs including one named after former Rep. Louis Stokes of Cleveland
A golden age of science is coming
It’s almost hard to remember, but just a few years ago, a lot of very smart people thought that science was in terminal decline. Respected researchers were writing papers with titles like “Are Ideas Getting Harder to Find?”, “Papers and patents are becoming less disruptive over time”, and “Slowed canonical progress in large fields of science”. In 1996, science writer John Horgan even published a book called The End Of Science: Facing The Limits Of Knowledge In The Twilight Of The Scientific Age. The fundamental idea was that the Universe only has so many insights to discover, and that we’ve picked the low-hanging fruit. It was the idea that Joseph-Louis Lagrange expressed when he said that “we cannot find more than once a system of the world to establish.” As the big ideas and the simple ideas get mined out, we’re forced to throw ever more brains at the mysteries of nature just to keep scientific progress going at a fraction of its old pace: It looked like science was hitting a wall. Then along came AI. It’s far too early to tell how much AI will eventually speed up the growth of total factor productivity. But already we can see signs of a speedup in science. Anthropic Founder Jack Clark assembled some of the hopeful data points in a recent lecture: [ Dror Poleg@drorpoleg "If you pick different parts of science, you see the same pattern show up: Progress is accelerating, and it has started to accelerate in the last two years." Jack Clark @jackclarkSF I’m speaking at the IMF in an hour about the singularity and why I believe it has begun and the choices we'll need to make. Watch live here: https://t.co/Hj9HzcXx5h 6:08 PM · Oct 18, 2026 · 21.2K Views 2 Replies · 10 Reposts · 123 Likes ](https://x.com/drorpoleg/status/2111882070376980529) Anthropic is accelerating its investment into drug discovery, and is already announcing some impressive preliminary results: [ BioTender@Junioryu136689 BREAKING: Anthropic unveils early results from six Claude-powered drug development collaborations. • 70% shorter CAR-T signaling domain • ~35,000 antibody designs • >10× tighter antibody binding • 89% less batch-record review time Still largely preclinical. Anthropic @AnthropicAI Over the past few months, Anthropic scientists have engaged in deep research partnerships with six organizations developing new medicines. We've also begun drug discovery efforts of our own. In doing so, we’ve learned much more about how Claude can support the many stages of 9:43 PM · Oct 27, 2026 · 11.2K Views 3 Replies · 24 Reposts · 205 Likes ](https://x.com/Junioryu136689/status/2115197821150495150) Claude also appears to be enabling rapid progress toward a treatment for food allergies. OpenAI, meanwhile, announced a possible breakthrough treatment for neurodegenerative disease. Meanwhile, Google Cloud Chief Scientist Pushmeet Kohli has a list of recent scientific advances that have been enabled by its new Gemini model, including breakthroughs in nuclear fusion reactor design, rare disease research, and quantum computing: [ Pushmeet Kohli@pushmeet Gemini 4 Argon is a step change in model performance. In recent weeks, it has had a transformative impact on the Science projects in our team at @GoogleDeepMind and our external collaborators, and helped make a number of remarkable advances across scientific disciplines. 🧵👇 4:47 PM · Oct 13, 2026 · 36.5K Views 8 Replies · 41 Reposts · 497 Likes ](https://x.com/pushmeet/status/2110049807385702623) But as cool as these stories sound, they’re just very minor, preliminary efforts. There are a number of reasons to think that AI is going to propel us into a golden age of scientific discovery. That age might not last forever — AI might still run into diminishing returns eventually. But the next few decades are probably going to be an absolutely amazing time for human science. The number of “effective researchers” is no longer limited The most important input into science is scientists themselves. Until this year, that meant human brains — talented, highly trained human brains. The number of trained human brains could be increased by sending more people to grad school, but only to a point — the smartest people tend to be sent into the hardest research fields first, and if you 10x the number of researchers, the average quality will go down. This constraint was already starting to bite, as Ekerdt and Wu argued in 2024: We argue that a substantial portion of the downward historical trend in U.S. research productivity is a composition effect resulting from self-selection in researcher ability and the dramatic expansion of the research sector…[W]e find that this composition effect has lowered average researcher ability by between 37% and 53%[.] And of course, low fertility was making the problem worse, because fewer children meant fewer people who were able to become future scientists. AI just blows up this constraint completely. If an AI agent can function as an autonomous researcher, there’s no constraint on the number of researchers in the world — you can just build more of them, by building more computer chips and data centers that enable the running of more AI agents. Whether or not massive hordes of agents can collaborate to solve individual problems much faster, increasing the number of agents allows them to tackle many different research questions in parallel. What’s more, these AI “researchers” can be trained incredibly quickly compared to human beings. A human scientist takes decades to train, and more years to reach the frontier of their research field by diligent reading and conversation. This is the “burden of knowledge”, and it’s commonly believed to be one reason ideas have been getting harder to find — by the time human scientists can get up to speed, they’re often so old that their ideas are no longer novel. AI just annihilates this constraint — it can assimilate the entire literature and reach the frontier of research extremely quickly, and it can also tell human scientists where the frontier lies without forcing them to discover that for themselves. It can also pivot to new research directions more easily than humans can. And there’s also a self-reinforcing economic cycle here. Because scientific advances enable higher GDP, they enable more resources to be invested into the creation of yet more electronic “scientists”. Now that doesn’t mean the amount of scientific research goes to infinity — there may still be some essential bottleneck task that human researchers are still needed to perform. There are some indications that AI’s progress on open-ended conceptual research tasks is slower than in other dimensions, and it may be that humans are still needed to provide some of this long-term conceptual thinking. I’d bet against this being true for much longer, but it might be true for a long time. Even in this most “pessimistic” case, though, the amount of effective capital that scientists can use to leverage their work just went up by a lot. AI eliminates the theory bottleneck Science proceeds by an iterative process of theory and experiment. The theory part of that cycle is typically short, but non-trivial — it took a couple of years after the blackbody radiation spectrum was observed for Max Planck to come up with the quantum hypothesis to explain it, and decades longer before quantum theory as we now know it was created. It took about a year for Watson and Crick to figure out the shape of DNA after the requisite data was gathered. AI will basically eliminate the theory bottleneck entirely — or at least shorten the turnaround time between experiment and theory by an order of magnitude. AI is an absolute beast at math. Recently, an OpenAI model solved some of the most important open problems in computer science, math, and theoretical physics, and no one even batted an eyebrow because that sort of triumph is becoming increasingly commonplace. One of those solutions was a proof that the Standard Model of Particle Physics could be mathematically well-defined — a problem that human theorists had so far been unable to tackle. Not all research relies equally on theory, but understanding novel experimental results almost always involves some important component of either mathematical or spatial reasoning. That part of the task has now been made much, much faster. And on top of that, science is now open to a greater number of humans who aren’t naturally good at theorizing. AI can read the whole literature Much of the work of human scientists involves reading and understanding endless amounts of papers and going to endless conferences and seminars. The purpose of that work is to understand the existing scientific literature. Understanding the literature allows scientists to do the following things: Come up with new ideas for hypotheses to test Avoid doing research that someone else has already done Synthesize approaches from different areas or fields AI can reduce this effort to almost zero. Consider this excerpt from OpenAI’s blog post about their new research into neurodegenerative disease: The team divided the analysis among thousands of AI agents powered by GPT‑Rosalind, an approach we call distributed biological reasoning. The agents examined a whole-brain CRISPR atlas…a dataset showing how gene disruptions affect different types of cells across the mouse brain. Each agent investigated a gene disruption, analyzed cellular responses, searched scientific literature, and proposed explanations for the results. Their reports were combined into a reasoning atlas linking genes, cellular effects, relevant publications, and possible biological mechanisms. The research team estimated that comparable human analysis and literature review, conducted one perturbation at a time, would take months to a year. The agents reproduced findings from human analyses while uncovering additional leads. Their assessments of novelty and scientific value also aligned with judgments from blinded human experts. These findings help prioritize further experiments needed to test the proposed biological mechanisms. Some of these insights point to new leads for understanding brain disease. [emphasis mine] This is one case in which parallel work by a large number of agents really does make a huge difference: [ Haider.@haider1 this is actually insane openai deployed thousands of GPT-Rosalind agents to analyze millions of mouse brain cells in 32 minutes, work that could take human researchers months to a year also the agents uncovered new leads for brain diseases like Alzheimer's and Parkinson's OpenAI @OpenAI GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in 2:41 PM · Oct 21, 2026 · 51.5K Views 26 Replies · 95 Reposts · 1.26K Likes ](https://x.com/haider1/status/2112917197903540516) Not only does instantaneous literature review vastly speed up the research process, but it allows AI to make novel conceptual leaps from combining approaches from wildly different fields of research. AI regularly does this in math research, combining results, approaches, and theorems from far-flung places that no human mathematician would have thought to combine. It can do it in science, too. Much of scientific innovation, historically, has been “recombinant” innovation — scientists applying insights from one field to another. With AI, essentially all research is now cross-disciplinary — AI can read not just the literature on a particular subject, but the literature on a million other subjects that might have produced useful techniques or insights for the problem at hand. Superscience So far, all of the factors I’ve listed are ways that AI can speed up science as it’s already done. I’ve basically described how AI can send gigantic hordes of superhumanly fast, superhumanly well-read, superhumanly mathematically gifted researchers to re-accelerate scientific discovery. But it’s also possible that AI will enable types of discovery — and ways of understanding the natural world — that no network of humans, no matter how large or how brilliant it was or how long it had to work, would ever be able to discover. In a post back in July, I wrote about how that might work: What if there are lots of…aspects of the Universe that [are] too complex to understand in terms of simple laws, but not so complex that they just dissolve into unknowable chaos? It’s possible that we can reliably control these complex phenomena with AI, even if we never reduce them to the kind of principles that we can teach a grad student in a textbook… Another way of saying this is that there may be laws of the universe that humans can’t understand but AI can. I call these “cloud laws” — causal regularities that can be exploited by technology, but which are too diffuse and complex for an individual human being to either intuit or communicate… Perhaps social sciences like economics, sociology, and political science obey similarly complex regularities, and AI can help us find them. Perhaps there are physical processes — plasma, or topological materials, or aerial turbulence, etc. — that obey cloud laws instead of chaos?… [H]uman collaboration is bottlenecked — it’s limited by our ability to intuit patterns at an individual level, and to communicate these patterns from one individual to another. AI, being a computer, just doesn’t have this sort of limitation; it can work with vast, diffuse patterns without having to break them into pieces or simplify them in order to compress them into the tiny pipelines of person-to-person explanation… If much of the Universe turns out to be ruled by cloud laws, we could be on the precipice of a scientific renaissance. In order to discover cloud laws, AI will need huge amounts of data about the natural world. AI figured out human speech by assimilating essentially all of the text humans have ever written. If it’s going to figure out hidden patterns in biology, neuroscience, materials science, etc., it’s going to need similarly massive amounts of data from physical instruments. That data will be far, far more than humans — individually or collectively — would be able to parse, label, characterize, or model. But AI was built to do this. If scientists simply build huge arrays of sensors to measure complex phenomena like the brain, the cell, the economy, etc., they may be able to feed this flood of data to AI directly and bypass human cognitive intermediation entirely. AI would then learn about the world directly, and it might learn things that humans never could. This “superscience”, if you want to call it that, would actually go beyond the kind of science humans have done heretofore. Many of the technologies it yielded would be beyond human comprehension — indistinguishable from magic. But to the AIs, they would make perfect scientific sense. In any case, it seems clear that the scientific slowdown that threatened human progress will now be delayed — at least for a while. Unless humans have somehow found most of the actual exploitable regularities in our Universe, we’re about to enter a new golden age of science. Subscribe Share
Fatigued Devils Fall 5-2 to Avalanche
In what is likely the most difficult situation they’ll face this season, the Devils couldn’t overcome an elite opponent on the second half of a back-to-back out west.
Vikings-Lions First Injury Report
The Minnesota Vikings and Detroit Lions released their first injury reports in advance of their Sunday afternoon matchup at Ford Field. Here they are. Minnesota Vikings Detroit Lions Injury Report Terms and Glossary Injury designation definitions: Probable = the league defines a Probable injury designation as a 75% or greater chance of playing. Historically, 95% […]
Trump calls for prosecution of Alaska Senate candidate Peltola over Sullivan name controversy
President Donald Trump called for the criminal prosecution of the Democratic candidate running for Senate in Alaska on Wednesday after revelations that her campaign appeared to be involved in recruiting a candidate with the same name as Republican incumbent Dan Sullivan.
Murphy USA posts higher revenues, profits
Quarterly revenue and profits rose for El Dorado-based Murphy USA as climbing fuel prices contributed to a stronger top and bottom line. Murphy USA reported Wednesday (Oct.28) third quarter net...
California Science Center Unveils New Air and Space Center
The California Science Center unveiled its new Samuel Oschin Air and Space Center Wednesday, featuring space shuttle Endeavour displayed vertically in a 20-story launch configuration ahead of the facility’s Nov. 13 public opening. The 200,000-square-foot expansion nearly doubles the Science Center’s exhibit space and includes 100 aerospace artifacts and 100 hands-on exhibits focused on science […]
Selena Gomez and Demi Lovato recreate their most iconic moments for new Rare Beauty campaign
Once a princess, always a princess.
Wisconsin basketball not taking unneeded risk with Will Garlock injury
Wisconsin forward Will Garlock is officially day-to-day after suffering an injury in practice. Here’s what Greg Gard told reporters about it.
Former Sabres Defenseman Makes Blunt Admission After Loss
The Buffalo Sabres traded away one player in the offseason who, just a season before, looked like a key addition.In June 2025, the Sabres traded JJ Peterka to the Utah Mammoth and acquired Josh Doan and Michael Kesselring. Ironically, only Doan remains with the team he was originally traded to and has become a staple […] The post Former Sabres Defenseman Makes Blunt Admission After Loss appeared first on HEAVY.
Think Your Business Is Ready to Sell? J.P. Morgan Says These 2 Problems Are Killing Deals
Inc. sat down with the head of JPMorgan's new banking team to see what it's looking for in the current tough deal environment.
Inter’s Matteo Lavelli: Behind the teenager’s rise at the Nerazzurri
At the weekend, Inter picked up a closely-fought 2-1 win over Fiorentina in the Serie A and it came in dramatic circumstances. The Nerazzurri grabbed two goals in stoppage time, completing yet another...
Empower Your Most Curious Employees to Drive Your Digital Transformation
Leaders seeking to turn AI’s promise into business value often overlook employees already experimenting with emerging technologies. These “digital wayfinders”—frequently younger, junior employees but defined by their exploratory approach rather than their age—can reveal new possibilities, challenge established assumptions, and accelerate digital transformation. Indeed, research involving almost 10,000 leaders across 108 countries suggests that organizations making greater progress are more likely to engage these employees. But these employees’ tendency to experiment without permission and challenge established thinking candidly can also send promising initiatives off track and alienate leaders. To channel their contributions productively, leaders should build candid, two-way communication; remove unnecessary bureaucracy while establishing clear business and ethical guardrails; and provide “air cover” through visible sponsorship and support and opportunities to influence consequential decisions.
Politics is medicine on a large scale
In February 1848, a 26-year-old doctor named Rudolf Virchow arrived in Upper Silesia, a poor, rural corner of Prussia that’s now part of Poland. A typhus epidemic was killing thousands, and the Berlin government wanted a doctor to assess how to contain this pathogen, advise local authorities, and propose a plan. Virchow spent a few weeks going from villa…
How data centers came to dominate politics in Maryland’s purplest county
Today, Frederick is home to Maryland’s only large-scale data center development, and its leaders are learning the hard way about the hazards of navigating the charged and changing politics of the industry, which critics decry for devouring energy, water and land.
JJ Redick: Lakers lacked defensive discipline during Tuesday's loss
Lakers coach JJ Redick commented on his team's defensive shortcomings in Tuesday's loss to the Trail Blazers.
EA shuts down legendary game studio BioWare after recent high-profile disappointments, controversies
Devils’ Gritsyuk Making Massive Impact in Second Season
When fans around the NHL think of the New Jersey Devils’ leading goal scorers, their mind likely goes immediately to Jack Hughes, Nico Hischier, or even Jesper Bratt. Most people won’t immediately think of Arseni Gritsyuk, a second-year NHLer who made the move from the Russian Kontinental Hockey League last season, yet there he is. […] The post Devils’ Gritsyuk Making Massive Impact in Second Season appeared first on HEAVY.
Celtics’ Jayson Tatum is finished commenting on Jaylen Brown situation
The trade of Jaylen Brown has already left fans speculating about a deep emotional rift between Jayson Tatum and Brown. Meanwhile, Brown’s recent pointed remark suggested that things might not be entirely smooth between the former teammates. As a result, Tatum once again faced questions about his relationship with Brown, but the Boston Celtics star […] The post Celtics’ Jayson Tatum is finished commenting on Jaylen Brown situation appeared first on ClutchPoints.
Grand jury refuses to indict former White House aide Cassidy Hutchinson, AP sources say
It's the latest setback in the Justice Department's efforts to charge Trump's perceived adversaries.
Pentagon creates advisory council on human performance, health
After creating a new directorate on warfighter optimization within the Department of Defense, the Pentagon announced it will form a federal advisory committee to weigh in on issues affecting troop performance and health.
Vance Joseph Augmenting Head Coaching Resume As Broncos' DC
After two trying seasons as head man of the Denver Broncos, Vance Joseph has returned to the Mile High City and constructed a formidable defense that could result in another head-coaching opportunity.
Man accused of sexual contact with patients at Glenwood Behavioral Health
A health professional faces seven felony sexual battery charges after patients accused him of unwanted sexual contact.
Ex-WWE Star Jake Hager’s Family Shares Health Update After Gruesome Eye Injury
It happened at a recent Power Slap event.
Jay-Z picks himself to headline the Super Bowl halftime show at SoFi Stadium in Southern California
Jay-Z will be the featured performer for the halftime festivities on Feb. 14 at SoFi Stadium in Inglewood, California.
Commentary: Health care should serve people, not the companies that profit from denying or delaying it
Medicare for All will not pass tomorrow. That is no reason to stop working for it, or to turn down reforms that help people in the meantime, writes N.H. union president.
Intermountain Health breaks ground on Nevada’s first stand-alone children’s hospital
Intermountain breaks ground on Nevada's first stand-alone children's hospital
Intermountain Health breaks ground on Nevada’s first stand-alone children’s hospital
Intermountain breaks ground on Nevada's first stand-alone children's hospital
Intermountain Health breaks ground on Nevada’s first stand-alone children’s hospital
Intermountain breaks ground on Nevada's first stand-alone children's hospital
Intermountain Health breaks ground on Nevada’s first stand-alone children’s hospital
Intermountain breaks ground on Nevada's first stand-alone children's hospital
Fantasy football IDP free-agent report: Week 8
This is our weekly Waiver Wire feature depicting the best individual defensive players to target on waivers in fantasy.
Political ads are evolving as campaigns embrace AI and digital technology
With less than a week until Election Day in the 2026 midterm elections, political campaigns are ramping up their advertising efforts, using digital technology a
Intermountain Health Breaks Ground on Felicia and Ben Horowitz Children's Hospital
Intermountain Health broke ground on the new Felicia and Ben Horowitz Children's Hospital Monday, celebrating progress in the work to create Nevada's first stan
Celtics handle business at home, beat Bulls 134-99
Tatum and Pritchard shine in a big win at home.
Healthcare costs are on the rise in Minnesota, a top issue for voters. How much more could you pay?
Newport Beach residents, business owners busy preparing for potential record-setting high tides
Star Entertainment returns to positive earnings and cash flow in first quarter
Star Entertainment Group has returned to positive earnings and operating cash flow for the first time in more than two years, helped by stronger revenue across its casino and resort portfolio and lower corporate costs. Ahead of its annual general meeting in Sydney, the casino operator...
Cavs vs. Timberwolves game thread
The Timberwolves could be the best opponent the Cavs have faced this season.
Friend Development Group highlights new businesses, local revitalization
Friend Development Group, Inc., is seeing new businesses and economic growth in Friend, and there are a number of shopping opportunities downtown.
Trump administration attempting to prosecute former FBI Director James Comey again
The Trump administration is attempting to prosecute former FBI Director James Comey for what it calls disclosing classified information, employing the unusual maneuver of bypassing a grand jury. Comey’s lawyers
Former Padres Prospect Is Now A World Series Starter
The San Diego Padres got beat by a former prospect in the playoffs, and Robert Gasser is starting in the World Series.
Israel’s election could reshape its politics, without changing its course on Palestine
Israel’s election could reshape its politics, without changing its course on Palestine
Is the U.S. Bank Business Essentials Visa worth it for your small business?
The U.S. Bank Business Essentials Visa offers unlimited 2% cash back on eligible purchases — and up to 2.5% back with an eligible U.S. Bank business checking account.
Arkansas basketball frontcourt is obvious point of focus
If Arkansas has a question mark, it's clearly the frontcourt
As Trump brags about U.S. oil and gas company profits, his stocks gained millions during Iran war
A report from congressional Democrats found the president purchased millions in oil and gas stocks during the war.
Inside Business 2026 Top Forty Under 40: Charles Bruce Jr., Drucker + Falk
Charles Bruce Jr. is the assistant director of human resources at Drucker + Falk.
Divided nation: Republicans prize patriotism, Democrats equality-Poll
As crucial midterms loom, a Gallup/With Honor survey found no consensus that basic American values are shared across party and other lines.
Ennis Rakestraw Jr. unable to return after ankle injury
Detroit Lions cornerback Ennis Rakestraw Jr. left the Week 7 game due to an ankle injury, and he was unable to return.
Wizards rule out AJ Dybantsa for fourth-straight match
The NBA world will have to wait another night to see AJ Dybantsa's NBA debut.
Over 300 students learn science and technology at CCSD Family STEM Day
Over 300 students learned about science and technology industries at the Clark County School District Magnet Schools Family STEM Day on Saturday.STEM Day as he
Alaska Democratic Senate candidate Mary Peltola and her family suffer minor injuries in car crash
Peltola required medical attention after the accident, which happened when another vehicle crashed into the one transporting Peltola and her family, the campaign said.
Defender turns striker and scores in Bayern win
Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...
Scientists Discover How Excess RNA Can Disrupt the Energy Supply Inside Cells
Scientists at Texas A&M University discovered that excess RNA can interfere with the machinery cells use to produce energy, even without triggering certain immune defenses. The findings reveal an unex...
Health care shakes up the Iowa election
If Democrats flip Congress, health care could find its way to the top of their 2027 agenda.
Lycia Lands a $317M IPO for Inflammation Drugs Based on Nobel Prize-Winning Science
Lycia Therapeutics’ protein-degrading drugs are based on the research of Carolyn Bertozzi, a Stanford chemistry professor and Nobel laureate. Lycia’s lead drug candidate is in development for food allergy, where it could compete against the blockbuster Roche drug Xolair.
Bloomington business continues to blossom
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ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Investment driving growth at NWS Crane
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Leafs’ Gavin McKenna Reveals True Thoughts On Connor McDavid
The Toronto Maple Leafs and Edmonton Oilers are facing one another in a Saturday evening showdown at Edmonton’s Rogers Place, marking the first time in the career of rookie forward Gavin McKenna that he’s facing Edmonton superstar captain Connor McDavid.McKenna, who has previously trained with McDavid over the summer, remains as much in awe of […] The post Leafs’ Gavin McKenna Reveals True Thoughts On Connor McDavid appeared first on HEAVY.
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