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Vikings-Lions First Injury Report
The Minnesota Vikings and Detroit Lions released their first injury reports in advance of their Sunday afternoon matchup at Ford Field. Here they are. Minnesota Vikings Detroit Lions Injury Report Terms and Glossary Injury designation definitions: Probable = the league defines a Probable injury designation as a 75% or greater chance of playing. Historically, 95% […]
Trump calls for prosecution of Alaska Senate candidate Peltola over Sullivan name controversy
President Donald Trump called for the criminal prosecution of the Democratic candidate running for Senate in Alaska on Wednesday after revelations that her campaign appeared to be involved in recruiting a candidate with the same name as Republican incumbent Dan Sullivan.
Murphy USA posts higher revenues, profits
Quarterly revenue and profits rose for El Dorado-based Murphy USA as climbing fuel prices contributed to a stronger top and bottom line. Murphy USA reported Wednesday (Oct.28) third quarter net...
California Science Center Unveils New Air and Space Center
The California Science Center unveiled its new Samuel Oschin Air and Space Center Wednesday, featuring space shuttle Endeavour displayed vertically in a 20-story launch configuration ahead of the facility’s Nov. 13 public opening. The 200,000-square-foot expansion nearly doubles the Science Center’s exhibit space and includes 100 aerospace artifacts and 100 hands-on exhibits focused on science […]
Selena Gomez and Demi Lovato recreate their most iconic moments for new Rare Beauty campaign
Once a princess, always a princess.
Wisconsin basketball not taking unneeded risk with Will Garlock injury
Wisconsin forward Will Garlock is officially day-to-day after suffering an injury in practice. Here’s what Greg Gard told reporters about it.
Former Sabres Defenseman Makes Blunt Admission After Loss
The Buffalo Sabres traded away one player in the offseason who, just a season before, looked like a key addition.In June 2025, the Sabres traded JJ Peterka to the Utah Mammoth and acquired Josh Doan and Michael Kesselring. Ironically, only Doan remains with the team he was originally traded to and has become a staple […] The post Former Sabres Defenseman Makes Blunt Admission After Loss appeared first on HEAVY.
Think Your Business Is Ready to Sell? J.P. Morgan Says These 2 Problems Are Killing Deals
Inc. sat down with the head of JPMorgan's new banking team to see what it's looking for in the current tough deal environment.
Inter’s Matteo Lavelli: Behind the teenager’s rise at the Nerazzurri
At the weekend, Inter picked up a closely-fought 2-1 win over Fiorentina in the Serie A and it came in dramatic circumstances. The Nerazzurri grabbed two goals in stoppage time, completing yet another...
Empower Your Most Curious Employees to Drive Your Digital Transformation
Leaders seeking to turn AI’s promise into business value often overlook employees already experimenting with emerging technologies. These “digital wayfinders”—frequently younger, junior employees but defined by their exploratory approach rather than their age—can reveal new possibilities, challenge established assumptions, and accelerate digital transformation. Indeed, research involving almost 10,000 leaders across 108 countries suggests that organizations making greater progress are more likely to engage these employees. But these employees’ tendency to experiment without permission and challenge established thinking candidly can also send promising initiatives off track and alienate leaders. To channel their contributions productively, leaders should build candid, two-way communication; remove unnecessary bureaucracy while establishing clear business and ethical guardrails; and provide “air cover” through visible sponsorship and support and opportunities to influence consequential decisions.
Politics is medicine on a large scale
In February 1848, a 26-year-old doctor named Rudolf Virchow arrived in Upper Silesia, a poor, rural corner of Prussia that’s now part of Poland. A typhus epidemic was killing thousands, and the Berlin government wanted a doctor to assess how to contain this pathogen, advise local authorities, and propose a plan. Virchow spent a few weeks going from villa…
How data centers came to dominate politics in Maryland’s purplest county
Today, Frederick is home to Maryland’s only large-scale data center development, and its leaders are learning the hard way about the hazards of navigating the charged and changing politics of the industry, which critics decry for devouring energy, water and land.
JJ Redick: Lakers lacked defensive discipline during Tuesday's loss
Lakers coach JJ Redick commented on his team's defensive shortcomings in Tuesday's loss to the Trail Blazers.
EA shuts down legendary game studio BioWare after recent high-profile disappointments, controversies
Devils’ Gritsyuk Making Massive Impact in Second Season
When fans around the NHL think of the New Jersey Devils’ leading goal scorers, their mind likely goes immediately to Jack Hughes, Nico Hischier, or even Jesper Bratt. Most people won’t immediately think of Arseni Gritsyuk, a second-year NHLer who made the move from the Russian Kontinental Hockey League last season, yet there he is. […] The post Devils’ Gritsyuk Making Massive Impact in Second Season appeared first on HEAVY.
Celtics’ Jayson Tatum is finished commenting on Jaylen Brown situation
The trade of Jaylen Brown has already left fans speculating about a deep emotional rift between Jayson Tatum and Brown. Meanwhile, Brown’s recent pointed remark suggested that things might not be entirely smooth between the former teammates. As a result, Tatum once again faced questions about his relationship with Brown, but the Boston Celtics star […] The post Celtics’ Jayson Tatum is finished commenting on Jaylen Brown situation appeared first on ClutchPoints.
Grand jury refuses to indict former White House aide Cassidy Hutchinson, AP sources say
It's the latest setback in the Justice Department's efforts to charge Trump's perceived adversaries.
Pentagon creates advisory council on human performance, health
After creating a new directorate on warfighter optimization within the Department of Defense, the Pentagon announced it will form a federal advisory committee to weigh in on issues affecting troop performance and health.
Vance Joseph Augmenting Head Coaching Resume As Broncos' DC
After two trying seasons as head man of the Denver Broncos, Vance Joseph has returned to the Mile High City and constructed a formidable defense that could result in another head-coaching opportunity.
Man accused of sexual contact with patients at Glenwood Behavioral Health
A health professional faces seven felony sexual battery charges after patients accused him of unwanted sexual contact.
Ex-WWE Star Jake Hager’s Family Shares Health Update After Gruesome Eye Injury
It happened at a recent Power Slap event.
Jay-Z picks himself to headline the Super Bowl halftime show at SoFi Stadium in Southern California
Jay-Z will be the featured performer for the halftime festivities on Feb. 14 at SoFi Stadium in Inglewood, California.
Commentary: Health care should serve people, not the companies that profit from denying or delaying it
Medicare for All will not pass tomorrow. That is no reason to stop working for it, or to turn down reforms that help people in the meantime, writes N.H. union president.
Intermountain Health breaks ground on Nevada’s first stand-alone children’s hospital
Intermountain breaks ground on Nevada's first stand-alone children's hospital
Intermountain Health breaks ground on Nevada’s first stand-alone children’s hospital
Intermountain breaks ground on Nevada's first stand-alone children's hospital
Intermountain Health breaks ground on Nevada’s first stand-alone children’s hospital
Intermountain breaks ground on Nevada's first stand-alone children's hospital
Intermountain Health breaks ground on Nevada’s first stand-alone children’s hospital
Intermountain breaks ground on Nevada's first stand-alone children's hospital
Fantasy football IDP free-agent report: Week 8
This is our weekly Waiver Wire feature depicting the best individual defensive players to target on waivers in fantasy.
Political ads are evolving as campaigns embrace AI and digital technology
With less than a week until Election Day in the 2026 midterm elections, political campaigns are ramping up their advertising efforts, using digital technology a
Intermountain Health Breaks Ground on Felicia and Ben Horowitz Children's Hospital
Intermountain Health broke ground on the new Felicia and Ben Horowitz Children's Hospital Monday, celebrating progress in the work to create Nevada's first stan
Celtics handle business at home, beat Bulls 134-99
Tatum and Pritchard shine in a big win at home.
Healthcare costs are on the rise in Minnesota, a top issue for voters. How much more could you pay?
Newport Beach residents, business owners busy preparing for potential record-setting high tides
Star Entertainment returns to positive earnings and cash flow in first quarter
Star Entertainment Group has returned to positive earnings and operating cash flow for the first time in more than two years, helped by stronger revenue across its casino and resort portfolio and lower corporate costs. Ahead of its annual general meeting in Sydney, the casino operator...
Cavs vs. Timberwolves game thread
The Timberwolves could be the best opponent the Cavs have faced this season.
Friend Development Group highlights new businesses, local revitalization
Friend Development Group, Inc., is seeing new businesses and economic growth in Friend, and there are a number of shopping opportunities downtown.
Trump administration attempting to prosecute former FBI Director James Comey again
The Trump administration is attempting to prosecute former FBI Director James Comey for what it calls disclosing classified information, employing the unusual maneuver of bypassing a grand jury. Comey’s lawyers
Former Padres Prospect Is Now A World Series Starter
The San Diego Padres got beat by a former prospect in the playoffs, and Robert Gasser is starting in the World Series.
Israel’s election could reshape its politics, without changing its course on Palestine
Israel’s election could reshape its politics, without changing its course on Palestine
Is the U.S. Bank Business Essentials Visa worth it for your small business?
The U.S. Bank Business Essentials Visa offers unlimited 2% cash back on eligible purchases — and up to 2.5% back with an eligible U.S. Bank business checking account.
Arkansas basketball frontcourt is obvious point of focus
If Arkansas has a question mark, it's clearly the frontcourt
As Trump brags about U.S. oil and gas company profits, his stocks gained millions during Iran war
A report from congressional Democrats found the president purchased millions in oil and gas stocks during the war.
Inside Business 2026 Top Forty Under 40: Charles Bruce Jr., Drucker + Falk
Charles Bruce Jr. is the assistant director of human resources at Drucker + Falk.
Divided nation: Republicans prize patriotism, Democrats equality-Poll
As crucial midterms loom, a Gallup/With Honor survey found no consensus that basic American values are shared across party and other lines.
Ennis Rakestraw Jr. unable to return after ankle injury
Detroit Lions cornerback Ennis Rakestraw Jr. left the Week 7 game due to an ankle injury, and he was unable to return.
Wizards rule out AJ Dybantsa for fourth-straight match
The NBA world will have to wait another night to see AJ Dybantsa's NBA debut.
Over 300 students learn science and technology at CCSD Family STEM Day
Over 300 students learned about science and technology industries at the Clark County School District Magnet Schools Family STEM Day on Saturday.STEM Day as he
Alaska Democratic Senate candidate Mary Peltola and her family suffer minor injuries in car crash
Peltola required medical attention after the accident, which happened when another vehicle crashed into the one transporting Peltola and her family, the campaign said.
Defender turns striker and scores in Bayern win
Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...
Scientists Discover How Excess RNA Can Disrupt the Energy Supply Inside Cells
Scientists at Texas A&M University discovered that excess RNA can interfere with the machinery cells use to produce energy, even without triggering certain immune defenses. The findings reveal an unex...
Health care shakes up the Iowa election
If Democrats flip Congress, health care could find its way to the top of their 2027 agenda.
Lycia Lands a $317M IPO for Inflammation Drugs Based on Nobel Prize-Winning Science
Lycia Therapeutics’ protein-degrading drugs are based on the research of Carolyn Bertozzi, a Stanford chemistry professor and Nobel laureate. Lycia’s lead drug candidate is in development for food allergy, where it could compete against the blockbuster Roche drug Xolair.
Bloomington business continues to blossom
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ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Investment driving growth at NWS Crane
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Leafs’ Gavin McKenna Reveals True Thoughts On Connor McDavid
The Toronto Maple Leafs and Edmonton Oilers are facing one another in a Saturday evening showdown at Edmonton’s Rogers Place, marking the first time in the career of rookie forward Gavin McKenna that he’s facing Edmonton superstar captain Connor McDavid.McKenna, who has previously trained with McDavid over the summer, remains as much in awe of […] The post Leafs’ Gavin McKenna Reveals True Thoughts On Connor McDavid appeared first on HEAVY.
Inter Milan vs Fiorentina – Predicted lineup and team news
Inter Milan welcome Fiorentina to the San Siro on Sunday for their next Serie A game, aiming to climb to the summit of the table.The Nerazzurri arrive in outstanding domestic form, having avoided defe...
Is the WA ‘millionaires tax’ really coming for public pensions?
SEATTLE — When you think about the mansion- and yacht-owning millionaire crowd, retired schoolteachers don't typically leap to mind. Nevertheless, foes of Washington's new high-earner income tax are making a
Jesse Welles sang about politics and insects — and covered Black Sabbath and Bob Dylan
The rapidly rising "Join ICE" protest singer played solo and with a band on North Broad Street, and covered Bob Dylan, Black Sabbath, and Creedence Clearwater Revival.
Brian Thomas Jr. could be on the move
Jaguars WR Brian Thomas Jr. is believed to be a trade candidate leading up to deadline
Firefly Species Lost to Science for Over 40 Years Rediscovered In a Nature Preserve in Delaware
Entomologist and ecologist Christopher Heckscher made the discovery when he noticed the firefly’s specific flash pattern
Many people ignore nerve discomfort. A specialist explains why
A podiatrist explains why many people overlook nerve discomfort and what makes Neuro-Blast different from traditional nerve-support supplements.
What should become a Detroit Lions tradition at Ford Field?
What fourth quarter tradition would best fit the Detroit Lions?
Indiana vs. Michigan: How to watch today's NCAA college football game, where to stream and more
How to watch the Indiana vs. Michigan game this Saturday.
Ballon d’Or Preview: Odds, prediction, and how to watch
FC Bayern’s Harry Kane is poised to add a new trophy to his growing collection.
Ausar Thompson Suffers Injury During Pistons Win over Heat
Detroit Pistons forward Ausar Thompson left Friday's game against the Miami Heat with an apparent lower-body injury, adding to concerns after Jalen Duren's exit.
Oregon’s famous Carver Cafe, featured in 'Twilight' movie series, listed for sale
Carver Cafe, known for its appearance in “Twilight,” is for sale as its owner prepares to retire, but the business says it remains open.
Memorial Health System holds ceremony for final beam at new Sistersville General Hospital
SISTERSVILLE – Hospital officials, community members, state and local leaders, and representatives of Memorial Health System and the Memorial Health Foundation gathered at the construction site of the new Sistersville General Hospital on Friday for a signing and dedication ceremony of the final steel beam prior to it being raised into place. “We are still […]
EAST TEXAS POLITICS: State party chairs weigh in as first week of early voting wraps up
Texas Democratic Party Chair Kendall Scudder and Republican Party Chair D’rinda Randall join Blake Holland for this week's show.
Argentine-born Trump supporter credits president for Latin America's rightward political shift
Marcelo Sandrin, who has lived in the US for three decades, points to Argentina's Javier Milei and changing politics across South America as signs of Trump's growing influence.
NASA’s Swift Mission Ends, Leaves Behind Scientific Bonanza
NASA’s Neil Gehrels Swift Observatory has ended its science mission now that the spacecraft is orbiting less than 171 miles (275 kilometers) above Earth’s
Watch “The Simpsons”’ spooky stop-motion “Nightmare Before Christmas” parody from ‘Treehouse of Horror’ (exclusive)
The new opening comes from Stoopid Buddy Stoodios, the stop-motion team behind “Robot Chicken.”
Ken Block objects to Foulkes' 'October surprise' Costco announcement
Block said that while he too was excited for Costco, he accused board member Helena Foulkes of abusing her position.
Chiefs’ Rashee Rice, Jaylon Moore out for SNF vs. Seahawks
The Kansas City Chiefs will be heading to Seattle without two of their starters.
J.J. McCarthy Could Solve One Massive Problem for Giants
New York Giants quarterback J.J. McCarthy could solve a huge problem for the team.
World Series in Milwaukee impacts high school sports, Bucks home opener
High school football and the Milwaukee Bucks are making changes to accommodate the Brewers and sports fans.
Raiders entering a critical 2-game swing
Las Vegas has big opportunity in next 2 weeks
Before We Abolish Business Schools, Let's Look Beyond The West
Can the case for abolishing business schools travel? India’s experience suggests the answer depends on context, writes Vikas Kumar.
Giants' Cutthroat Najee Harris Move is Surprisingly Refreshing
The New York Giants' decision to cut Najee Harris this week was surprisingly refreshing.
Things to know when buying a business
Reverse due diligence isn't a typical business practice. But it should be.
T.J. Hockenson practices Thursday
Minnesota Vikings TE T.J. Hockenson a full go at Thursday's practice
Full practice for Jordan Addison
Minnesota Vikings WR Jordan Addison logs full practice on Thursday
Florida resident arrested after threatening US Rep. Jared Moskowitz
FORT LAUDERDALE, Fla. — A Boca Raton resident was arrested Thursday after making an alleged threat against U.S. Rep. Jared Moskowitz, the congressman announced. Just after 2:30 p.m., Moskowitz wrote
Is Raiders' Running Back Ashton Jeanty's Production Cause For Concern?
The Las Vegas Raiders have now dropped three straight, and concerns are growing about their star running back's production.
Clavicular pleads not guilty to raping a 17-year-old
'Looksmaxxing' influencer Braden Peters, a.k.a. Clavicular, has pleaded not guilty to charges that he raped a teenager at his family home.
Eagles to release E.J. Jenkins ahead of Cowboys matchup
The Eagles are releasing E.J. Jenkins, according to Mike Garafolo. The tight end appeared in all six games this season, making two starts
Peoples Could Become Rangers’ Future Setup Man for Latz
Armed with a 96-mph heater and elite contact suppression, Ben Peoples possesses the raw velocity and metrics to anchor a dominant late-inning bridge for the Texas Rangers.
Omaha Science Café Explores the Wild World of Spiders Oct. 27
UNL biologist Eileen Hebets, PhD, presents a talk on spiders at the Oct. 27 Omaha Science Café at the Rathskeller Bier Haus. Open to ages 21 and older.
Health insurance gaps leave families struggling with costs, survey finds
A new survey from GoodRx finds that even people who have health insurance are increasingly underinsured.
Health insurance gaps leave families struggling with costs, survey finds
A new survey from GoodRx finds that even people who have health insurance are increasingly underinsured.