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“Shame On All The People” – Martina Navratilova Condemns Olympic Gold Medalist Imane Khelif’s Boxing Comeback In Paris

Tennis legend Martina Navratilova reacted to the news of Imane Khelif returning to the boxing ring on Dec. 15 in Paris.

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Nov 9 • 5:49 AM EST • Sports • sports.yahoo.com
PSG drop Ibrahim Maza pursuit

Paris Saint-Germain have completely dropped their pursuit of Bayer Leverkusen forward Ibrahim Maza (20), as per a report from Sacha Tavolieri. The Algerian had been touted as a potential January recru...

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Nov 9 • 4:07 AM EST • Sports • sports.yahoo.com
Carlos Alcaraz claims he’s taken ‘one step forward’ with his tennis after winning the title in Paris

Carlos Alcaraz has claimed yet another ATP title after battling past Ben Shelton in the final of the Paris Masters. Alcaraz beat Shelton 7-6(7-5), 7-5...

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Nov 9 • 3:00 AM EST • Sports • sports.yahoo.com
Rubio Will Discuss Iran, Ukraine, AI and More With G7 Allies in France

PARIS (AP) — U.S. Secretary of State Marco Rubio will meet his counterparts from the Group of 7 industrialized democracies on Monday, with unresolved world crises on the agenda and questions about how President Donald Trump will approach foreign policy after his Republican Party’s massive losses in ...

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Nov 9 • 12:01 AM EST • Politics • usnews.com
Science Teacher Goes Viral for Being the ‘Real-Life’ Miss Frizzle of ‘Magic School Bus’

Lisa Herring, who took her school photo with her class’ bearded dragon Rango, has gone viral, drawing comparisons to the lovably zany Miss Frizzle and her lizard pal Liz.

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Nov 8 • 5:36 PM EST • Science • today.com
Alcaraz downs Shelton to win Paris Masters for first time

Carlos Alcaraz gained a measure of revenge on Ben Shelton on Sunday as the seven-time Grand Slam champion beat the American 7-6 (7/5), 7-5 to win the Paris Masters for the first time.In the earlier doubles final, French pair Quentin Halys and Pierre-Hugues Herbert upset second seeds Neal Skupski and Christian Harrison as the wildcards triumphed 7-6 (7/3), 6-7 (4/7), 10-8. nf/ea

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Nov 8 • 1:03 PM EST • Sports • sports.yahoo.com
The Candle: The code that copies itself in science

Around this time of year, my biology course for science majors begins exploring the core processes of cell biology.

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Nov 8 • 7:00 AM EST • Science • theparisnews.com
Oral cavity and throat cancers are up 20% since 2000 in Louisiana. See the parish data.

Since 2000, the incidence rate per 100,000 people for oral cavity and oropharyngeal cancers grew by nearly 20% in Louisiana and by nearly 10% in the U.S. , according to

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Nov 8 • 5:00 AM EST • Health • nola.com
Alcaraz sets up Shelton rematch in Paris final

Carlos Alcaraz says he is ready for "one of most difficult challenges in tennis" after setting up a rematch against Ben Shelton in the Paris Masters final.

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Nov 7 • 2:54 PM EST • Sports • sports.yahoo.com
NBAA President Ed Bolen retires after 22 years, citing health issues

Bolen played an integral role advocating for business aviation, including during the COVID pandemic and the formation of Climbing Fast

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Nov 7 • 12:37 PM EST • Health • privatejetcardcomparisons.com
I got the same order at Chipotle and Qdoba: Comparison, winner

I compared the same chicken burrito bowl, chips, and hot salsa order at Chipotle and Qdoba to see which chain restaurant has the best food and value.

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Nov 7 • 11:08 AM EST • Business • businessinsider.com
Bradley Barcola explains why he left PSG to join Liverpool

Bradley Barcola says it was the “right time” to leave Paris Saint-Germain when he joined Liverpool in the summer transfer window. The Reds shelled out an initial £106 million to sign the winger, ...

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Nov 7 • 9:54 AM EST • Sports • sports.yahoo.com
iPhone Duo vs. Galaxy Z Fold 8 Camera Comparison: Frolicking With Apple's and Samsung's Foldables

I snapped some photos in a dreamy garden with these passport-size phones to see how their rear cameras stack up.

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Nov 7 • 8:00 AM EST • Technology • cnet.com
Small business in St. Charles Parish tries to recover after tragic hit-and-run

See the moment a car crashed through the doors of a small business weeks away from grand opening

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Nov 6 • 7:28 PM EST • Business • wdsu.com
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New GTA6 Screenshots have released comparing real life cars to in Game Cars

Just moments ago, brand new Grand Theft Auto VI screenshots were released showing off some of the in game vehicles, with a side by side comparison to the real life versions of the cars. The Iconic…

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Nov 6 • 3:21 PM EST • Technology • rockstarintel.com
Louisiana got $200M to shore up rural health care. Hospitals question how it’s being spent.

“The rural hospitals were deeply disappointed with the amounts that we got from the Rural Transformation grants,” said Paul Mathews, CEO of Hardtner Medical Center in La Salle Parish.

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Nov 6 • 12:55 PM EST • Health • nola.com
St. Tammany Parish budget hearing sparks emotional debate over mental health services

A public hearing in St. Tammany Parish revealed concerns over budget cuts that could impact nonprofit mental health services, with tense exchanges between community members and officials.

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Nov 5 • 10:43 PM EST • Health • wdsu.com
What’s next for Caddo Parish sports complex after voters reject $60M bond?

Caddo Parish voters reject a $60M bond for a proposed $70M sports complex. Local leaders react, citing misinformation and urgency over regional population loss.

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Nov 5 • 6:19 PM EST • Sports • ksla.com
After Career in Business, Dave Winter Serves Hometown as Parish Life Director

The former investment manager and local shoe store owner now turns his skills, education, and experience to leading Holy Cross Parish in Springfield, Delaware County.

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Nov 5 • 1:19 PM EST • Business • catholicphilly.com
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Warriors' Growing Drama Compared to 76ers' Ben Simmons Disaster

Former Philadelphia 76ers star Ben Simmons is finding himself placed in comparisons with Golden State Warriors center Kristaps Porzingis.

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Nov 5 • 1:00 PM EST • Sports • sports.yahoo.com
Who has the edge between the Patriots and Packers?

A head-to-head comparison between the Patriots and Packers ahead of their Sunday meeting.

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Nov 5 • 9:12 AM EST • Sports • sports.yahoo.com
The Legend of Zelda: Ocarina Of Time's 2026 Remake Looks Stunning Next To The Original N64 Game

What a difference, a few decades make.

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Nov 5 • 8:21 AM EST • Technology • gamespot.com
Four Match Points, Another Collapse, and the Frances Tiafoe Problem

Frances Tiafoe was serving for the match at 5-4 in the deciding set against Quentin Halys at the Paris Masters after recovering from a disastrous opening set. He took control of the match and put himself within touching distance of the third round, but then he lost his serve. No matter. He still managed to …

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Nov 5 • 7:35 AM EST • Sports • sports.yahoo.com
European Enterprises Face Growing Pressure to Turn AI Investment into Business Value, ISG Says

PARIS, November 05, 2026--The ISG AI Impact Summit will explore operating models and data and governance frameworks to scale AI, November 9–10 at the Pullman Paris Tour Eiffel.

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Nov 5 • 4:00 AM EST • Business • finance.yahoo.com
Innate Pharma Reports Third Quarter 2026 Business and Financial Update

MARSEILLE, France, November 05, 2026--Regulatory News: Innate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) ("Innate" or the "Company") today reported its financial update for the nine months ended September 30, 2026.

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Nov 5 • 1:00 AM EST • Business • finance.yahoo.com
76ers Must Ignore Celtics’ Paul George Jaylen Brown Noise

The Celtics are comparing Paul George to Jaylen Brown after a few games. Per The Sixer Sense, those comparisons ignore the real stats and the LeBron factor.

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Nov 4 • 1:46 PM EST • Sports • sports.yahoo.com
UT Martin student attends national forensic science academy

UT Martin senior Harlee Veazey of Paris hopes to have a career in law enforcement investigations.

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Nov 4 • 10:43 AM EST • Science • news.utm.edu
Back to the Future with Jean-Baptiste Lamarck

Lamarck believed that “all living beings are constantly transforming themselves” and thus life forms shape their own evolution.

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Nov 4 • 9:44 AM EST • Science • scienceandculture.com
Slack vs Discord; a comparison for businesses

Slack vs Discord were built for different audiences, one for work, one for communities. See which platform actually fits business teams best.

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Nov 3 • 11:46 PM EST • Business • salesforce.com
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Caddo Parish voters reject $60 million bond for proposed sports complex

Approved: Caddo Parish voters have approved a $60M bond measure to help fund a proposed $70M sports complex in Shreveport. Full election results here. Rejected: Caddo Parish voters have rejected a $60M bond measure proposed to fund a $70M regional sports complex in Shreveport. Full election results here.

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Nov 3 • 11:32 PM EST • Sports • ksla.com
The Last Disney+ Original?

(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) Before we get going, I wanted to remind readers about how I plan to keep your trust while I add advertising to this newsletter. As you’ve no doubt noticed, I’m running ads now, but the danger is that it could impact my analysis and writing. I have a list of sponsors on my About Page, so if you think I’m biased, you can check out who’s sponsored this newsletter! This is something that I’m not sure anyone else in digital media does (if you’re a writer or media outlet and you do this, let me know and I’ll shout you out!) but it’s something I’d love to see embraced by the entire industry. Sunlight, i.e. transparency, is often the best disinfectant. Okay, on to this week’s issue. We (finally) have another major Disney+ TV show to talk about, so that’s my main focus for today. Plus, we had a lot of new shows come out, including the fourth seasons of The Diplomat and Tulsa King! And Love is Blind! The Lowdown! Also, four (four!) straight-to-streaming films came out this week, featuring a lot of big names and celebrities, so I’m going to look at those. All that, mixed news for the WNBA, Reacher ends its run on the charts, Skydance does well in September viewership, NYU’s Sundance dominance, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of October 12th to October 18th, 2026. You can find a link to my terminology here.) Subscribe Television - Disney+’s Porridge Problem Listen, per my headline, VisionQuest isn’t the last Disney+ Original. At least, I’m pretty sure it’s not. They have other MCU shows in development. Well, maybe one: But it sure feels like the end of an era. I’d call it their “porridge too hot” era, to quote myself from The Ringer. I told Ben Lindbergh that Disney+ seemingly couldn’t figure out the right amount of content. In the heights of the Streaming Bubble Era (circa 2019 to 2022), they started releasing an insane amount of TV shows. After their growth slowed, they’re down to two or three shows a year, and that might be down to 1 by 2027. Here’s my TV shows by year chart: Even at the time, I thought Disney was making too many shows (that cost too much). Today? They’re definitely making too few shows (though the budgets are more in check, at least according to the reporting). Porridge too hot, porridge too cold; too many shows, now not enough. Which makes evaluating VisionQuest so interesting. This show didn’t have a great lead-in, whether it be a Marvel Cinematic Universe film (the last non-Sony-produced-Spider-Man flick came out The Fantastic Four from July of 2025) or Marvel Cinematic Universe TV show (the two this year were Wonder Man back in January and _Daredevil: Born Again_in May, both of which underwhelmed). And so far, VisionQuest hasn’t quite recaptured the MCU Originals glory, but it has some signs of sparks. First, it made Samba TV, though at a lowly ninth place. At least it made it, a feat some other Marvel shows didn’t accomplish. (Ironheart landed on the Samba TV charts one week at tenth place, but Wonder Man and Daredevil: Born Again both missed.) VisionQuest also made Luminate, though with only 3.0 and 7.6 million hours. But it missed Nielsen in its first week. The best news might be its 7.8 on IMDb, on 12K reviews so far, great numbers, even for a superhero show. Looking at those numbers, this show will really need to pick up in future weeks—and it may since it’s coming out weekly—or Disney will have another disappointment on its hands. Disney+ binge-released their last few shows to try to boost numbers, but that meant shows like Iron Heart and Wonder Man didn’t last long on the charts. _Daredevil: Born Again’s_last season missed entirely (though it came out weekly). Here’s the Disney+ Originals by totals: And for a fun new look, here are those same shows, rearranged by the years they came out: That really shows that, in addition to Disney+ releasing fewer shows, those shows just don’t hit like they once did. If I had to offer one main explanation, it’s that Marvel Studios moved away from characters who starred in the Avengersmovies (The Scarlett Witch, Vision, Hawkeye, Loki, Falcon, Winter Soldier) to characters who didn’t (Moon Knight, She-Hulk, Iron Heart, Wonder Man, Daredevil). It sounds trite, but more popular IP tends to do better than less popular IP. In Marvel’s case, beloved, decades-old characters trump newer ones. And yes, I think this is a problem for Disney. The failure of Marvel TV shows to linger for weeks on the charts, unlike in 2021 and 2022, explains why Disney’s share of the charts has plummeted: That’s a strategic issue. Yes, these shows are really expensive, but without them, Disney+ will struggle, especially if Disney+ keeps raising prices AND licenses out its shows non-exclusively. My recommendation? Return to the core value proposition, which is Disney+ as “genre HBO”. The goal is six shows a year, coming out weekly, spaced out throughout the year. When a show hits, keep it coming back. Make three to four of those shows Marvel or Star Wars, and fill out the rest with IP swings like Percy Jackson, Goosebumps or something like National Treasure. And make YA-skewing shows like Coven Academy to fill out the schedule. Disney, you can get this porridge just right, er, make the right number of shows. Quick Notes on TV Netflix’s sophomore, er, junior, er, senior season slump abated very, very slightly this week. I speak of The Diplomat, which returned for its fourth season on 15-Oct. Credit where credit is due, this show debuted in April of 2023, and has put out new seasons every year since. Has that helped the viewership? Not really. This season opened to 16.4 million hours, which is down significantly from the first season (21.7 million hours) and down somewhat from the second season (18.0 million hours), but it is up from last year’s 14.2 million hours opening. On Samba TV, it opened to third place; that’s also very good. On Luminate, it opened to 25.0 million hours, which is good, but over thirty million hours is a hit on that platform. Netflix wisely renewed it, since it’s steady and, frankly, Netflix needs hits.1 Paramount+ put out Tulsa King’s fourth season on a Friday. After putting out most of their big, usually-Taylor Sheridan-scripted shows out on Sundays last year, they’ve clearly moved to Fridays going forward. Was this a thought-out strategic change, Netflix mimicry, or a data-inspired move? Tough to say. Fridays are crowded with new movies, but so are Sundays with new shows. Anyways, this one is coming out weekly, and we haven’t seen it hit the Nielsen or Luminate charts yet. But it did make Samba TV at fifth place, which is a good opening. Still, if this doesn’t make Luminate or Nielsen next week, I’d call it a disappointment. Netflix had two unscripted shows hit the charts this week, one a docu-series and one a reality competition show. Tyson is a four-episode docu-series about one of boxing’s most popular fighters, and it made both the Samba TV and Luminate charts, but not Nielsen. That’s a solid run for only four episodes (assuming it didn’t cost an arm and a leg to produce). Netflix’s latest season of Love Is Blind also returned for its eleventh season, which opened to 10.0 million hours, down from previous seasons. It also had 11.0 million hours according to Luminate, roughly in line with the Nielsen numbers. Last issue, I analyzed the triple successes of Below, Carrie and Crystal Lake, noting that all three have done well. I mostly used Nielsen, but all three shows also made Samba TV (see above). Crystal Lake in particular did very well on Luminate, getting 35.0 million hours, top for Peacock among first seasons: The top “show” of the week would have been Thursday Night Football again, at 41.7 million hours. This is still above last year’s game, but it continues the season’s overall downward trend, which happens every year. (Though a big week is coming, based on the news stories I’ve seen.) As I said before, I’ll do a deeper dive on all the October games later this month, with comparisons to previous years. One company is quietly on a roll, when you consider the shows it makes and streams. I speak of Skydance—a point Variety made—noting that it produces Neagley and Reacher for Amazon, along with Paramount+’s Lioness, which means it produced three of the top four shows of September according to Nielsen. By the way, Neagley fell off the Nielsen charts after four weeks, which is a pinch short for how well it started, but it’s still a huge success. (Interestingly, it finished just 7.3 million hours ahead of the cancelled Ride or Die.) The point, though, which I’ve made before, is that Prime Video still has a problem with how many co-productions it buys, most notably _The Boys_from Sony and Reacher/Jack Ryan from Skydance. It’s not a critical flaw—everyone licenses shows—but Amazon still struggles to make its own hits. Reacher finally fell off the Nielsen charts, so here’s its final rank for season four: We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… ...An example of the algorithm NOT picking a film… …whether or not Netflix buys shows simply for the movie poster… ...if East of Eden is above the Obliterated Line... ...what four star-studded straight-to-streaming films didn’t chart... ...and a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue.

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Nov 3 • 7:03 PM EST • Entertainment • entertainment.substack.com
PSG Breaks Champions League Record With 4 Goals In 17 Minutes

Paris Saint-Germain faced a test of its squad strength with four of its best players missing for the trip to Villarreal in the Champions League on Tuesday.

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Nov 3 • 4:01 PM EST • Sports • foxsports.com
Paris Jackson requests dad Michael’s estate transfer $600 million to a trust fund for her and brothers

Paris Jackson requests that her father Michael Jackson’s estate transfer $600 million to a trust for her and her brothers, per instructions in his will.

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Nov 3 • 1:20 PM EST • Entertainment • ew.com
OpenAI: ChatGPT Search Is About 20% of Google’s, 250 Million People Speak With ChatGPT, and Chat Is Merging With Work

OpenAI says ChatGPT growth is accelerating. The company added 200 million users over just the past two months, jumping from 1 billion to 1.2 billion weekly active users in 60 days. Its search volume, it says, is approximately 20% of Google’s. Its users create 1.5 billion images with it per week. And its voice mode, between dictation and speaking with ChatGPT, now has 250 million combined weekly active users. ChatGPT consumer product lead Adam Fry told me this during a brief fireside chat at an OpenAI-hosted dinner in New York City on Monday night. “The growth is just going big,” he said. During our conversation, Fry also revealed plans to merge ChatGPT’s Chat and Work modes (so that confusing toggle up top will soon go away), agreed with feedback that ChatGPT-created restaurant signage looks too uniform, and addressed the cost to serve its personal assistant Dots. Here’s a look at our full conversation, lightly edited for clarity and length. We also cover image generation, interactive interfaces, advertising, education, and public unease about AI: Alex Kantrowitz: OpenAI has analyzed ChatGPT’s search volume and compared it with Google’s. What did you find? Adam Fry: ChatGPT has been growing quite quickly. ChatGPT’s volume of search-like queries is now roughly one-fifth the volume of queries of Google. It’s a pretty amazing statistic when you think about it, mainly because we started just about a year and a half ago. It’s hard to remember this, but ChatGPT at a time didn’t have any up-to-date information. You’d ask a question, it would say something like, “It’s past my training date,” and nobody had any idea what that meant. You’re saying ChatGPT’s search volume is one-fifth of Google’s. Bing’s share of the search market is around 5%. Does that make you multiple times larger than Bing? To say that more directly, ChatGPT has gone from one billion to 1.2 in just the last two months. That’s roughly 100 million users in 30 days, and another 100 million in another 30 days. The growth is just going big, and we’re staying very focused on how fast ChatGPT is growing. What counts as a search? I might have 20 prompts back and forth in a ChatGPT conversation. Does each one count as a query? Story continues below… A MESSAGE FROM OUR SPONSOR Move upmarket without a rebuild Moving upmarket means saying yes to what enterprise buyers ask for first: SSO, directory sync, and audit logs. WorkOS gives you all three, so your team keeps building the product instead of the checklist. Get enterprise-ready. Continued from above…. Adam Fry: What people came to ChatGPT for to start, if you go back about two years, is really writing help and coding help. Those wouldn’t be things that you really search for. What we’ve seen over the last year is people have grown into all these other topics. Things like you’re looking up a person or people or a place or a thing, and it requires up-to-date information. That’s a key element. Another big part is finance questions or health questions, where you really want to make sure it’s up-to-date information that’s quite factual, and we’ll do a web search for those questions. It’s basically anything that a user would have traditionally gone to a traditional search engine for, but is now deciding to go to ChatGPT for. Does each conversation with a search embedded count as one search, or does every question that requires a web search count? Every time you ask a question and go search the web, that’s a search. You used to work at Google. How would you say the nature of search is changing? One of the things that people really love about ChatGPT is this personalization and this understanding of the broader journey. If you look in the past, people would go for a Q&A box, and you’d ask a one-off question, like how tall is the Eiffel Tower. But there’s so much context in our lives around, “Maybe I’m taking a trip to Paris.” It’s actually helpful for ChatGPT to respond, “Here’s how tall the Eiffel Tower is, but I know you’re going on a trip to Paris.” It’s that ability for people to actually maintain context over time that has led them to start using ChatGPT in this way. You’ve also announced 250 million weekly active users of voice input, including dictation and conversations with voice mode. We are at 250 million weekly active users. What’s amazing about this is, if you look at those 250 million, what we’re seeing is it’s actually also incremental to the product. It’s no longer just a novelty. People aren’t just trying out voice. We’re seeing them use voice input day to day in their daily life, and it’s grown so quickly. Those 250 million users are using voice input, and that could just be a quick question or a long conversation. We’re seeing both behaviors. We’re seeing people just not want to type. You just hold it and start talking to it, or it turns into a longer conversation where people just sit with it. The big reason for this is the frontier capabilities of our models that we’ve shipped. We shipped what we call GPT Live 1, and then we shipped GPT Live 1.1. The big change with this is that it’s much more natural to speak with. It’s something we call backchanneling and interruptibility. Mhhhm… What you just did there is what the model does, because it’s really good at having a bidirectional conversation. That push to the frontier—we were the first to really release this at scale—has made it so much more natural for people to chat. That’s still only about 20% of the user base. From the outside, that looks small. Why is it exciting from the inside? It’s very exciting for a few reasons. We see from the data that when people start using voice, they stay around using voice. One of the things, transparently, we can do a better job of is bringing more people into discovering it. We see that the number of people who discover it could be a lot higher. But once they do, it’s a really new way for people to interact with AI. We’ve made a lot of improvements to it too, where we’re just going to see the number go up. You have background mode, so now by default, if you close the app, it’ll show, “Hey, the conversation’s still going.” If you want to walk around the house or you’re putting away the groceries, you can still have a chat. That kind of continuity has also changed how much people use it. Dots launched on September 29 and is about a month old. How’s it doing? It’s doing great. We talk to people about their Dot, and the first thing that everyone says is, “I love my Dot.” One of the reasons we’re seeing this is the proactivity, its ability to reach out to you and figure out things. The biggest use case I see all the time is, “Did I forget something today that I was supposed to do?” You can just say to your Dot, “Remind me of things at the end of the day that I may have forgotten. Somebody emailed me or messaged me,” and it’ll do that. This Dot changes the paradigm of the relationship with AI, where it’s actually helping you and giving you time back. You’re more conservative with permissions than some competitors. I tried to give my Dot my credit card, and it wouldn’t take it. With the creator of OpenClaw in-house, why are Dots’ permissions more limited? This is a space where we want to be very thoughtful and conservative because it’s a new space where you’re entrusting your Dot to take care of things on behalf of you that matter and are meaningful. We’ve just talked about how you go to this 1.2 billion user growth and asking questions. Now we’re asking people, “Can you ask ChatGPT or your Dot to help get things done?” But when you ask it to help get things done, it’s a whole new level of trust. We’ve built up a tremendous amount of trust in giving the right answers to your questions, and we want to make sure that when we build this new product, it has a high degree of trust. It’s a long game. We think this is going to be a new market for a very long time, and we want to make sure that we’re being this trusted player in the market to start. I initially thought Dots would be available on my $20 plan, then realized I had to spend $100 a month to get it. I upgraded, but I’d like to downgrade at some point…. We hope to keep earning your business and make the value good enough. It’s a really good point. ChatGPT’s goal more broadly, which I think is unique for us in the market, is we are focused on bringing intelligence to everyone safely across the entire world. For Dots in particular, there’s no difference. We don’t have anything to share tonight about the date of when Dots will go to a broader set of users. But you can rest assured we’re working very hard, and there are a couple things we have to get right. Over time we’re going to work on more efficient, agentic models that are able and capable of doing things for you. The first one is, right now we wanted to make sure that your Dot is actually really helpful. We started with some of our best models, but over time we’re going to work on more efficient, agentic models that are able and capable of doing things for you. The second thing is around proactivity. We’re still dialing in: How much do I message you to help you get things done? We can always play around with that to understand how much usage should a user use to have a successful Dot. We’re going to work on both, and our goal and ambition is to bring it out to all users. How much background computing does a Dot require? I’ve read estimates that serving a $100 subscriber might cost OpenAI $3,000 in compute, and mine seems to read every email that arrives. How often is it checking connected data sources? Right now, Dots are on the compute-heavier side, and this is one of the things we want to make sure that we can dial back over time. But the goal is to give you the best product. This is our premium, always-on personal assistant. Once we nail that, we’ll figure out how to dial back the compute needs. The thing we’re seeing also from our models, as we train frontier models, is just how—I can’t even keep up with how quickly we have a new model, and each new model is more efficient. If you looked at 6.1 Sol when it came out relative to Astra, much more efficient. I’m very excited about the next set of models we have coming too that’ll be even more efficient that we can use. Elon Musk said the cost of serving Grok Bot was unsustainably high relative to revenue. Is efficiency the key to winning against competitors, or is there more to it? There are a couple of factors that go into it. One is the cost side, but the other is the revenue side. On ChatGPT and on our consumer business, we’ve been extremely proud of our ability to diversify different revenue streams in a way that’s growing really fast. To give you another stat, we announced several months back that we had passed 50 million subscriptions, and the number has grown considerably since then. On ads, within 200 days, we reached more than a billion in ARR, and that business is growing extremely quickly. We also have credits. Rather than paying for subscriptions, users can buy more credits. Between credits, subscriptions, and ads, I’m confident that the value of a Dot is going to be able to pay for itself. Elon has subscriptions too. This is clearly an expensive product to serve. One thing we continue to bet on at OpenAI and ChatGPT more broadly is that the models will continue to get much better and much cheaper, way faster than any of us think. If you look back at the historicals on it, it continues to be true. From what I’ve seen, I see no slowing down of that. What is Meta doing right with Muse? It has spent a lot of time atop the App Store charts. There are a couple of things they’ve done well. The first is people have been craving simplicity in their products. One of the things we have stated publicly as well is, at times AI products can be too complex. We’ve announced we’re merging ChatGPT’s Chat and Work. We’re making it much more simple in the products. You don’t have as many toggles or sliders between efforts and different model pickers. One of the things they’ve done well is this simplicity. You just go in and you can ask a question. You don’t have to think too much about what you’re doing. That’s one thing that seems to have resonated with users, which we also believe in. Second, there’s something really nice about being able to access your agent across many different channels. We just announced and launched Dots on iMessage. Whether you talk to your Dot on email or iMessage or within the ChatGPT app, the ubiquity in getting your assistant out there is going to be key. Those are two things that, if I had to be nice to our competitors, I would say were two big ones. So Alexandr Wang’s meme-tweeting strategy isn’t something you’re going to emulate? I have a different tweeting style. ChatGPT still asks me to choose between Chat and Work, even though some people call this technology AGI. Will that distinction go away? Couldn’t agree more. We have to solve this. Asking users to choose — we’ve heard repeatedly from all of our users it’s too much to understand. When should you go to Chat? When should you go to Work? It’s solvable. There’s real research to solve to make sure the models can understand what your intent is. Are you asking for a fast, quick reply? Are you asking me to go do a long agentic task? We’re going to solve it, and the plan is to bring Chat and Work together. So one interface will work out whether I’m asking for a conversation or a task. When? Coming soon. You told me the majority of ChatGPT’s 1.2 billion users are using image functionality. What are they doing? Today, 1.5 billion images are created per week. It’s hard to even wrap my head around that number. They’re doing a wide range of things. One of the most interesting things they’ve started to do is really use it for productivity use cases. The first thing it started with—I don’t know if you saw the ’80s trend, but it was quite fun. You could take a photo of yourself and say, “Put me and my family in ’80s outfits.” I did this for my family, and it was a really fun poster. But what we’re also seeing is businesses for their menus, or posters for birthdays. People are using it almost in a productivity-like fashion to create visual diagrams of what they would like to see. We’ve actually brought the latency down on images as well, so it’s gotten a lot faster. It went from a very high number of seconds to getting much faster. As it comes down even further, the number of images people are creating and the number of use cases is going to grow a lot. My feature request: When a restaurant makes a menu or sign, prompt it for more specificity so it doesn’t look like every other AI-generated restaurant sign. Or offer a shuffle button for a different style. I agree with the feedback, and we’ll take it to the team. I’m seeing ChatGPT generate little interactive interfaces within its answers. What’s the direction for Intelligent UI, and how are people using it? I am extremely excited about Intelligent UI. If you go back a couple years, these chat apps were all text, and now that’s changing. They’re going to be visuals. Intelligent UI and our first attempt at this with GPT-6 Intelligent UI is really just the beginning. As you go to the extreme, what you can imagine is, let’s say you’re using voice mode, and you just say, “Show me how offside works.” Immediately it should show you a visual diagram, and you say, “No, I don’t quite understand it.” It should just repopulate. That’s where the future of this technology goes. It’s almost like you’re talking to a canvas that will update and change. People are finding it helpful for a lot of things. My favorite one is—it’s hard to admit that I had no idea how hearts work. The last biology course I took was in high school. I just asked it, “How does the heart work?” and it instantly gave me a beautiful interactive diagram of where blood flows and how it goes through. I’m really, really bullish on this for learning in particular. You’ve described useful applications in finance, health, and learning, and ChatGPT has 1.2 billion users. If people are getting so much value, why is public polling on AI so negative? The reality with AI is it is going to change the nature of how work gets done. For a lot of people, that is something that can feel scary at times, and we’ve all felt that. But I remain confident that when people actually use the product and they use AI, it very quickly changes how they perceive it. We’re at 1.2 billion, but there are still a lot of people who haven’t used it. The more people use it, get familiar with it, how it can actually help you in your life, it’s going to feel a lot less scary. Big Technology is a reader-supported publication. To receive new posts and support our work, please consider becoming a paid subscriber. Thanks!! Subscribe

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Nov 3 • 10:00 AM EST • Technology • bigtechnology.com
Extreme heat no longer confined to summer, extending health risks, study finds

There was a time when, across large swathes of the world, the seasons fed into each other in a relatively predictable cycle of warmer and colder weather. In temperate nations, frigid winter thawed into spring. Spring bloomed into summer, where extreme heat beat down until cooler weather provided autumn’s relief. No longer. A recent study […]

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Nov 2 • 3:16 PM EST • Health • news.mongabay.com
Celebrities at the Launch of WYouth

Hailey Bieber, Whitney Peak, Paris Hilton and more attend the WYouth launch.

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Nov 2 • 12:37 PM EST • Entertainment • yahoo.com
My mom invented a stroller blanket. Now we run the business.

Chana Campora's mom invented a stroller blanket after moving to NYC from Paris. Now they run the baby gear company 7 AM Enfant together.

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Nov 2 • 8:57 AM EST • Business • businessinsider.com
'Lankshear destined for international recognition'

BBC Radio 5 Live's Adam Cottier makes a case for why he thinks Will Lankshear is worthy of the Harry Kane comparisons.

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Nov 2 • 4:16 AM EST • Sports • sports.yahoo.com
One-of-a kind musical farewell for Jackie Jackson

WESTERN BUREAU: Had it not been for the thick walls of the historic St James Parish Church, all of Montego Bay might have heard saxophonist Dean Fraser pouring his heart into Dance With My Father on Saturday. It was that kind of farewell. Not simply a funeral service, but an extraordinary musical tribute to Clifton ‘Jackie’ Jackson, the legendary Jamaican bassist whose fingers helped create the heartbeat of some of the world’s most recognisable reggae and rocksteady recordings.

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Nov 2 • 1:06 AM EST • Entertainment • jamaica-gleaner.com
Sopra Steria Completes Acquisition of the Manufacturing Engineering Business From Daher Industrial Services a Group Daher Subsidiary

PARIS, November 02, 2026--Regulatory News: Sopra Steria (Euronext Paris: SOP), a major tech player in Europe, has announced that it has completed its acquisition of the Manufacturing Engineering business from Daher Industrial Services to bolster its expertise in aerospace engineering.

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Nov 2 • 1:00 AM EST • Business • finance.yahoo.com
Immaculate Conception Parish Center hosts annual health fair

It was all treats and no tricks for Clarksburg community members seeking free health services at Immaculate Conception Parish Center.

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Nov 1 • 7:10 PM EST • Health • wboy.com
Cryosphere faces permanent damage when world overshoots 1.5C, scientists warn

UN-backed report finds even temporary rises above Paris agreement target could cause harm to glaciers and polar ice sheets

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Nov 1 • 7:01 PM EST • Science • theguardian.com
Sean Dyche Makes Oliver Glasner Comparison

Sean Dyche has compared Nottingham Forest's current situation under Oliver Glasner to his own tenure at the club.

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Nov 1 • 5:45 PM EST • Sports • sports.yahoo.com
Paris Hilton Is Morticia Addams in Plunging Cristallini Velvet Dress

Paris Hilton fully embraced spooky season by transforming into Morticia Addams for an elegant family Halloween photoshoot. The media personality shared a series of cinematic photos on Instagram, capti...

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Nov 1 • 3:56 PM EST • Entertainment • yahoo.com
Harriet Dart beats Austria's Lilli Tagger to win first WTA Tour title at Guangzhou Open

Britains Harriet Dart defeats Lilli Tagger to take home her first WTA title at the Guangzhou Open on Sunday; You can watch the ATP Paris Masters live on Sky Sports from Monday November 2

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Nov 1 • 5:59 AM EST • Sports • skysports.com
Paris FC predicted XI v Monaco: Luca Koleosho out

Paris FC will be without winger Luca Koleosho as they prepare to host AS Monaco at the Stade Jean Bouin on Sunday afternoon. Koleosho, an Italy international who has been in fine form in recent weeks,...

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Nov 1 • 3:15 AM EST • Sports • sports.yahoo.com
Immaculate Conception Parish Center hosts annual health fair

The community was also able to enjoy and even participate in Tai Chai and line dancing demonstrations throughout the duration of the health fair.

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Oct 31 • 6:29 PM EDT • Health • wboy.com
Science Spooktacular Returns to Elkhart County 4-H Fairgrounds for Halloween

WSBT CBS 22 provides news, sports, entertainment and public interest programs to the South Bend, Indiana area including Mishawaka, Notre Dame, Granger, Osceola, Elkhart, Jimtown, Dunlap, New Carlisle, Goshen, Middlebury, Bristol, New Paris, Nappanee, Howe, Lagrange, Topeka, Bourbon, Milford, Syracuse, North Webster, Warsaw, Bremen, Plymouth, Walkerton, Argos, Tippecanoe, Culver, Grovertown, Delong, Rochester, Akron, Winamac, North Judson, LaPorte, North Liberty, Wakarusa, Lapaz, Millersburg, Knox, and Michigan City, Indiana – and these areas of Michigan: St. Joseph, Benton Harbor, Buchanan, Niles, Three Oaks, New Buffalo, Harbert, Bridgeman, Stevensville, Watervliet, Berrien Springs, Dowagiac, Marcellus, Cassopolis, Decatur, Vandalia, Constantine, White Pigeon, Galien and Edwardsburg.

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Oct 31 • 5:31 PM EDT • Science • wsbt.com
5 Players Withdraw from ATP Paris

The final Masters 1000 of the season, ATP Paris, has arrived, a rare one-week event that could finalize the lineup for the ATP Finals. The draw is stacked, but several players will be absent as they are unable to compete in this final stretch. Which Players Have Withdrawn from ATP Paris? Defending champion Jannik Sinner’s …

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Oct 31 • 4:52 PM EDT • Sports • sports.yahoo.com
Le Havre owners sack coach after PSG thrashing

Struggling French Ligue 1 club Le Havre on Saturday sacked Didier Digard as coach and accepted the resignation of chairman Jean-Michel Roussier following a 5-1 home thrashing by Paris Saint-Germain.In a statement, the owners said they had "accepted the principle of Mr. Jean-Michel Roussier's resignation from his position as chairman".

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Oct 31 • 4:36 PM EDT • Sports • sports.yahoo.com
Best Celebrity Halloween Costumes: Kim Kardashian as North West, Paris Hilton as Britney Spears and More

Halloween and Hollywood go hand in hand, especially given that most costumes draw inspiration from entertainment. From iconic movie characters to musicians to pop culture phenomena, the costume refere...

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Oct 31 • 1:18 PM EDT • Entertainment • yahoo.com
Flick convinced Barcelona will bounce back from successive defeats

Hansi Flick is convinced Barcelona will rebound from the painful back-to-back defeats to Paris Saint-Germain and bitter rivals Real Madrid. Barça welcome Alaves to the Nou Camp in LaLiga on Saturday looking to bounce back from a 2-1 home El Clásico setback that followed a 4-2 loss at the Champions League holders in France.

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Oct 30 • 3:03 PM EDT • Sports • sports.yahoo.com
SurfOS issues business update, state of affairs since launch

As aircraft operator Surf Air Mobility continues its tech push and Palantir partnership, SurfOS issued update on progress and expectations.

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Oct 30 • 11:22 AM EDT • Business • privatejetcardcomparisons.com
SurfOS issues business update, state of affairs since launch

As aircraft operator Surf Air Mobility continues its tech push and Palantir partnership, SurfOS issued update on progress and expectations.

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Oct 30 • 11:22 AM EDT • Business • privatejetcardcomparisons.com
Orioles GM Names Surprise Example for Gunnar Henderson’s Comeback

Jared Banner’s Cubs comparison offers an intriguing clue to how the Orioles could help Gunnar Henderson improve after a difficult 2026 season. The post Orioles GM Names Surprise Example for Gunnar Henderson’s Comeback appeared first on HEAVY.

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Oct 29 • 7:27 PM EDT • Sports • sports.yahoo.com
Caddo Magnet High teacher to appear on Jeopardy Thursday

SHREVEPORT, La. — A local high school teacher will showcase his trivia knowledge on national television Thursday afternoon.Andrew Medlin, an English and philosophy teacher at Caddo Parish Magnet High School,

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Oct 29 • 1:27 PM EDT • Entertainment • ktbs.com
ADOCIA Reports Third Quarter 2026 Financial Results and Provides a Business Update

LYON, France, October 29, 2026--Regulatory News: Adocia (Euronext Paris: FR0011184241 – ADOC, the "Company"), a clinical-stage biopharmaceutical company focused on the research and development of innovative therapeutic solutions for the treatment of metabolic diseases including diabetes and obesity, reports financial results for the third quarter of 2026 and provides a business update.

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Oct 29 • 1:00 PM EDT • Business • finance.yahoo.com
Alumnus to speak on 'AI in mental health' for February Paris Lecture

Dr. Samuel Faulkner, a 2013 Campbell University graduate, licensed psychologist a nationally certified school psychologist, will be the featured speaker… More on this post

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Oct 29 • 12:35 PM EDT • Health • news.campbell.edu
Maryland women’s basketball gets ‘unreal’ opportunity in Paris opener

In 2008, Maryland women’s basketball first faced South Carolina in Cancún, Mexico. Nearly 18 years later, the programs will meet for the 10th time — and once again, in a different country. No. 20 Maryland will face No. 1 South Carolina on Monday at Adidas Arena in Paris to open its season. The game is part of the Oui-Play event, which has featured college women’s basketball matchups in Paris ...

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Oct 29 • 8:00 AM EDT • Sports • sports.yahoo.com
Caddo Parish voters to decide $60M bond for sports complex

Caddo Parish voters will decide Tuesday whether to approve a $60 million bond for a new sports complex.

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Oct 28 • 11:11 PM EDT • Sports • ksla.com
Call For New WHO Instrument To Address Climate-Driven Global Health Emergency

A decade after the Paris Agreement took effect, climate-related heat, drought, floods, disease and dirty air are killing millions. The authors of a major

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Oct 28 • 3:30 PM EDT • Health • healthpolicy-watch.news
Saints power rankings: NFL Week 7

Where do the Saints rank after their loss in Paris?

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Oct 28 • 12:30 PM EDT • Sports • sports.yahoo.com
Mental health, disability training for Texas parish leaders aims to meet 'dire need'

Training parish leaders to address mental health concerns is

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Oct 28 • 11:25 AM EDT • Health • osvnews.com
Avondale, operating at capacity, to spend $50 million on warehouse, railway, dock expansion

A logistics hub in Jefferson Parish is investing $50 million into expanding its operation and constructing new warehouse space for a future tenant.

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Oct 28 • 9:00 AM EDT • Business • nola.com
Cheesecake Factory’s longtime designer calls Obama jab ‘pettiness of politics’

Cheesecake Factory’s former vice president of design, Rick McCormack, criticized former President Barack Obama’s comparison of the White House’s gold decor to the restaurant’s, calling it “the pettiness of politics.” McCormack told CNN he f…

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Oct 28 • 8:17 AM EDT • Politics • baltimoresun.com
Employer health plan costs to soar in 2027. How to compare and save

Health insurance costs are rising fast, making comparison shopping more important this year, experts said. Here's how.

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Oct 28 • 5:01 AM EDT • Health • usatoday.com
Business briefs: Caesars offers Nevada residents free parking, dining discounts

The participating resorts are Caesars Palace, the Vanderpump Hotel, Harrah’s Las Vegas, Flamingo Las Vegas, the LINQ, Paris Las Vegas, Horseshoe Las Vegas and Planet Hollywood, including its Miracle Mile Shops garage …

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Oct 28 • 5:00 AM EDT • Business • lasvegassun.com
Climate change intensifies global health risks, Lancet Countdown report warns

The 2026 Report of the Lancet Countdown on Health and Climate Change finds that many of the health risks and harms of climate change grew faster in the decade since the Paris Agreement was introduced (2016–2025) than in the decade before it (2006–2015).

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Oct 27 • 11:00 PM EDT • Health • news-medical.net
😐 Neutral (10%)
Further Thoughts on the Googlebook, in Comparison to the MacBook Air

I’ve had the Googlebook now for a couple of weeks, and I have gotten a chance to both use it on a regular basis, and compare it with the MacBook Air I have (it sports an M4 processor). One of…

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Oct 27 • 8:56 PM EDT • Technology • whatever.scalzi.com
Steelers-Saints in Paris generates 7.7 million on Sunday morning
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Oct 27 • 8:46 PM EDT • Sports • sports.yahoo.com
The Cost of Lagging Global Climate Action Is Lost Lives and Poor Health

A new report finds health harms from warming outpaced progress after the Paris Agreement and calls for climate change to be declared a global health emergency.

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Oct 27 • 8:01 PM EDT • Health • insideclimatenews.org
The global stakes of France’s political and fiscal crisis

Experts discuss what the crisis means for France's upcoming elections as well as Paris's role in defending Europe and supporting Ukraine.

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Oct 27 • 1:32 PM EDT • Politics • atlanticcouncil.org
Comparisons on social media linked to mental health problems

Comparing oneself with others on social media is more strongly associated with symptoms of anxiety and depression among adolescents than using social media to pass the time. This is shown by a study of ...

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Oct 27 • 12:00 PM EDT • Health • medicalxpress.com
A spike in business travel and events spurs 2027 optimism for Hilton

Company expects strong revenue growth for hotels next year despite difficult comparison

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Oct 27 • 10:59 AM EDT • Business • costar.com
Nithya Raman Is Not L.A.’s Mamdani. But She Might Become Mayor, Too.

Little known a year ago, Nithya Raman is a Democratic Socialist drawing comparisons with New York’s Zohran Mamdani. She has mounted a strong challenge to the incumbent, Karen Bass.

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Oct 27 • 10:24 AM EDT • Politics • nytimes.com
AmTrust acquires Wakam’s French and U.K. businesses

U.K.-headquartered AmTrust International Ltd. has acquired Paris-based Wakam SA and London-based Wakam U.K. Ltd., Coverager reported. The acquisition expands Amtrust’s insurance operations across…

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Oct 27 • 10:23 AM EDT • Business • businessinsurance.com
PSG, best men's club of the 2026 season

PSG are crowned the best men's club of the 2026 season. Paris Saint-Germain have been named the best men's club of the season, retaining last year's title. Luis Enrique's team won their second consecu...

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Oct 26 • 6:02 PM EDT • Sports • sports.yahoo.com
Recap: Saints play Steelers in inaugural Paris matchup

Catch up on all the action from France.

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Oct 26 • 4:19 PM EDT • Sports • sports.yahoo.com
Aaron Rodgers was good enough in Paris, but RBs were sublime: Steelers report card
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Oct 26 • 4:16 PM EDT • Sports • sports.yahoo.com
Ups and Downs from Saints vs. Steelers

Not a lot looked good in the Saints loss in Paris.

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Oct 26 • 10:30 AM EDT • Sports • sports.yahoo.com
Cam Heyward roasts Steelers QBs over European Peaky Blinders outfits

Cameron Heyward called out Pittsburgh Steelers quarterbacks for excluding the defense from their coordinated Peaky Blinders suits in Paris.

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Oct 26 • 10:02 AM EDT • Sports • sports.yahoo.com
Three things we learned from the United States Grand Prix

Kimi Antonelli stands at the threshold of Formula One's hall of fame, needing just two more points to become the sport's youngest champion and first Italian for 73 years.With five races remaining, AFP Sport looks at three things we learned from the 20-year-old Italian's ninth win of an outstanding season: Antonelli maturing fast and adding strategic authority to his arsenal A brief comparison with the misfortunes and struggles of his teammate and nearest rival George Russell reveals how rapidl

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Oct 26 • 9:43 AM EDT • Sports • sports.yahoo.com
8 Players Withdraw from ATP Vienna & Basel

The 2026 ATP season has nearly come to a close, and it’s in the middle of the final push, with 500s in Vienna and Basel leading up to the Paris Masters and the ATP Finals. Several players won’t be able to finish their seasons strong, though, as they have withdrawn from these two stacked draws. …

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Oct 26 • 7:15 AM EDT • Sports • sports.yahoo.com
Kane primed to pip Yamal, Mbappe to Ballon d'Or glory

England captain Harry Kane is the favourite to win a wide open race to be crowned Ballon d'Or winner at a glitzy London ceremony on Monday, with Lamine Yamal and Kylian Mbappe also in the running to be named the world's best footballer.- 'I deserve it' - Yamal finished second to Paris Saint-Germain's Ousmane Dembele last year and the 19-year-old Barcelona superstar seems destined to be a Ballon d'Or winner one day.

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Oct 26 • 12:34 AM EDT • Sports • sports.yahoo.com
French and Italian Retailers Tally Losses Ahead of Holiday Season

Retailers in France and Italy face financial losses and security concerns as protests disrupt business ahead of the holiday shopping season.

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Oct 25 • 3:57 PM EDT • Business • wwd.com
Retailers in Paris React to Protests [PHOTOS]

Retailers Assess Cost of Lost Business After Second Round of Protests

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Oct 25 • 3:08 PM EDT • Business • wwd.com
Steelers stock report after Week 7 win over Saints

Stock up, stock down, after the Steelers Week 7 win in Paris over the New Orleans Saints.

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Oct 25 • 1:35 PM EDT • Sports • sports.yahoo.com
Steelers beat Saints to win first NFL game in Paris

The Pittsburgh Steelers defeated the New Orleans Saints 16-10 on Sunday to win the first-ever NFL regular season game in Paris. The low-scoring game had only one touchdown for each team.

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Oct 25 • 1:03 PM EDT • Sports • sports.yahoo.com
Warren, Steelers stiff-arm Saints for 16-10 Paris win

Jaylen Warren had another big day and the Pittsburgh Steelers overcame some red-zone inefficiency to beat the New Orleans Saints.

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Oct 25 • 12:42 PM EDT • Sports • sports.yahoo.com
Saints Lose Defensive Battle in Paris Against Steelers

A very winnable game that a better team would have won.

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Oct 25 • 12:36 PM EDT • Sports • sports.yahoo.com
Jaylen Warren and the Steelers run over the Saints in Paris
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Oct 25 • 12:35 PM EDT • Sports • sports.yahoo.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Saints vs. Steelers in Paris: Week 7 game chat

The Saints face the Steelers in this Week 7 matchup. Join us here for the game!

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Oct 25 • 9:29 AM EDT • Sports • sports.yahoo.com
☹️ Negative (-40%)
Rico Dowdle active for Week 7

Rico Dowdle will suit up versus Saints in Paris

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Oct 25 • 8:39 AM EDT • Sports • sports.yahoo.com
Steelers Get Good News on Rico Dowdle

Pittsburgh Steelers running back Rico Dowdle (knee) is active for Sunday’s game against the New Orleans Saints in Paris after […]

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Oct 25 • 8:27 AM EDT • Sports • sports.yahoo.com
Paris Pressure: Saints Must Block Out the Chaos and Finish Their Business Against the Steelers
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Oct 25 • 7:00 AM EDT • Business • sports.yahoo.com
Steelers vs Saints live updates, TV info, start time, stream NFL Paris game

The Steelers are in the middle of a AFC North divisional dog fight as they look to win the first NFL regular season game on French soil.

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Oct 25 • 5:00 AM EDT • Sports • sports.yahoo.com
Steelers Add New Uniform Combination for Paris Game

Pittsburgh is switching up its usual road look for Sunday's matchup against the Saints in France. Here's how the new combination compares with the Steelers' other uniform looks.

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Oct 24 • 7:00 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-13%)
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100%
Jay-Z burnishes his legend at SoFi Stadium

After earlier stadium shows in New York, London and Paris, the 56-year-old rap superstar touched down in Inglewood for a set overflowing with hits.

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Oct 24 • 3:46 PM EDT • Entertainment • latimes.com
Pittsburgh Steelers vs. New Orleans Saints: How to watch the NFL international game, start time, where to stream and more

Find out how to watch the Pittsburgh Steelers vs. New Orleans Saints NFL Paris game this week.

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Oct 24 • 2:30 PM EDT • Sports • sports.yahoo.com