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JESPY Trivia Friendraiser

Put your trivia skills to the test for a great cause! Join JESPY for a fun-filled Trivia Night on Sunday, November 8, 2026, from 5–8 p.m. at Avenue Pub in Maplewood.Gather your friends, enjoy some...

tapinto.net logo
Oct 25 • 8:30 PM EDT • Entertainment • tapinto.net
Local business expert recommends reporting scams via BBB scam tracker

The Better Business Bureau warned the public about phishing scams and advised consumers to regularly check their bank and credit card statements to identify fraudulent activity.

fourstateshomepage.com logo
Oct 25 • 8:08 PM EDT • Business • fourstateshomepage.com
Attackers kill nurse, severely injure health worker responding to Ebola case in eastern Congo

The World Health Organization reports that a nurse has been killed and a health worker severely injured in an attack while responding to an Ebola alert in Congo.

clickondetroit.com logo
Oct 25 • 8:01 PM EDT • Health • clickondetroit.com
😐 Neutral (13%)
Claude AI accessed publicly available Georgia voter data, Anthropic confirms

Officials said the AI bot accessed publicly available voter data through the state's data hub but did not access voter files or Georgia's voter registration system.

foxbusiness.com logo
Oct 25 • 8:00 PM EDT • Business • foxbusiness.com
Deep dive
😐 Neutral (3%)
ahah
100%
Panera closes in Dillon, Underground Snowboards gets new owners and more business news

Panera Bread has closed its Dillon location less than four years after opening, adding to a growing list of national restaurant chains that have shuttered businesses in the area. The establishment at 257 Dillon Ridge...

summitdaily.com logo
Oct 25 • 8:00 PM EDT • Business • summitdaily.com
$5,000 checks, political attacks and winding remarks: Takeaways from Trump’s Michigan rally
mlive.com logo
Oct 25 • 7:49 PM EDT • Politics • mlive.com
Why OU's win over Mississippi State sparks cautious optimism

OU took down Mississippi State on the road with a dominant offensive performance on Saturday.

oudaily.com logo
Oct 25 • 7:48 PM EDT • Sports • oudaily.com
Australian politicians pay tribute to wounded lawmaker

Australia's prime minister and fellow parliamentarians led sombre tributes Monday to "beacon of decency" and colleague Helen Haines, who remains in hospital after being struck by a car outside her off...

yahoo.com logo
Oct 25 • 7:40 PM EDT • Politics • yahoo.com
Dad shares ‘complaints’ about his toddler’s restaurant business and it’s too adorable

"It's a very clean establishment, but whewww let me tell you about this owner."

upworthy.com logo
Oct 25 • 7:31 PM EDT • Business • upworthy.com
Health network adding helicopter in rapid Pennsylvania expansion

WESTMORELAND COUNTY, Pa. (WHTM) — Not long after they acquired five Pennsylvania hospitals, a health system will soon launch an air medical helicopter in the Keystone State. WVU Health System…

abc27.com logo
Oct 25 • 7:15 PM EDT • Health • abc27.com
Health network adding helicopter in rapid Pennsylvania expansion

WESTMORELAND COUNTY, Pa. (WHTM) — Not long after they acquired five Pennsylvania hospitals, a health system will soon launch an air medical helicopter in the Keystone State. WVU Health System recently...

yahoo.com logo
Oct 25 • 7:15 PM EDT • Health • yahoo.com
50 Cent Trolls Rick Ross After His Son's Alleged Attack

The rapper and entertainment mogul joked that he plans to bail out the suspect who allegedly assaulted Ross' son, William Roberts III.

yahoo.com logo
Oct 25 • 7:15 PM EDT • Entertainment • yahoo.com
Donald Trump praises Nicki Minaj’s ‘beautiful ass’ during rally speech: ‘It’s hard to miss’

Donald Trump made a lewd comment at the lectern while speaking at a Michigan rally about the anatomy of one of his strongest supporters, Nicki Minaj.

ew.com logo
Oct 25 • 7:01 PM EDT • Entertainment • ew.com
“Odegaard was outstanding” but Merson was less complimentary about Gyökeres

Paul Merson has delivered contrasting verdicts on two Arsenal players following Saturday’s comfortable 2-0 victory over Everton, singling out Martin Ødegaard for praise while questioning Viktor Gy�...

sports.yahoo.com logo
Oct 25 • 7:00 PM EDT • Sports • sports.yahoo.com
9th Circuit panel questions basis for feds' request to block 20,000 California ballots

Two judges questioned the Justice Department's lawyer about how the Trump administration's position squared with the law.

latimes.com logo
Oct 25 • 6:54 PM EDT • Politics • latimes.com
West Louisville business transforms into soul food restaurant, arcade
whas11.com logo
Oct 25 • 6:47 PM EDT • Business • whas11.com
Veteran Makers Market highlights importance of supporting veteran-owned businesses

The Veteran Makers Market spotlights veteran-owned businesses, encouraging shoppers to support those turning military skills into local success.

wndu.com logo
Oct 25 • 6:24 PM EDT • Business • wndu.com
😐 Neutral (14%)
love
100%
Sunday Sports: Section 3 football matchups announced and more

Here’s a recap of your North Country sports this Sunday.

wwnytv.com logo
Oct 25 • 6:24 PM EDT • Sports • wwnytv.com
Pistons' Ausar Thompson ruled out against Sixers

The Pistons will be without Ausar Thompson on Sunday night for their match against Philadelphia.

sports.yahoo.com logo
Oct 25 • 6:22 PM EDT • Sports • sports.yahoo.com
Absent Vinícius Jr. ‘laughs’ at Barcelona after Real Madrid victory

Real Madrid star Vinícius Jr. has on Sunday evening taken to social media, to issue his response to his side’s victory over arch rivals Barcelona.José Mourinho’s troops made the trip to the Spo...

sports.yahoo.com logo
Oct 25 • 6:20 PM EDT • Sports • sports.yahoo.com
Serbia’s Vucic concedes defeat in seismic political shift

The long-serving strongman leader of Serbia, Aleksandar Vucic, has conceded defeat in an election that pitted him and his right-wing party against a diverse student-led opposition movement that spent two years protesting his government

latimes.com logo
Oct 25 • 6:11 PM EDT • Politics • latimes.com
Over 300 students learn science and technology at CCSD Family STEM Day

KSNV NBC Las Vegas covers news, sports, weather and traffic for the Las Vegas, Nevada area including Paradise, Spring Valley, Henderson, North Las Vegas, Indian Springs, Sloan, Searchlight, Laughlin and Nellis AFB.

news3lv.com logo
Oct 25 • 6:00 PM EDT • Science • news3lv.com
Walnut Ridge business starts coat drive for community

The Farm Service Tire Center in Walnut Ridge is hosting its first-ever coat drive, running now through Dec. 21.

kait8.com logo
Oct 25 • 6:00 PM EDT • Business • kait8.com
Packers defensive tackle Devonte Wyatt questionable to return after injury

Green Bay Packers defensive tackle Devonte Wyatt questionable to return after injury vs. Detroit Lions.

sports.yahoo.com logo
Oct 25 • 5:52 PM EDT • Sports • sports.yahoo.com
Peoria business leader accused of DUI in deadly UTV crash

A business executive well known in the local sport community has been arrested on drunk driving accusations for a crash that killed a woman late Saturday night in rural Peoria County.

25newsnow.com logo
Oct 25 • 5:48 PM EDT • Business • 25newsnow.com
iFixit iPhone Duo Teardown Points to Possible Cause of Screen Cracks
macrumors.com logo
Oct 25 • 5:43 PM EDT • Technology • macrumors.com
Hinge damage suspected to be behind iPhone Duo screen cracks

The cause behind a repeating pattern in the way a very small amount of iPhone Duo screen cracks may have been discovered, with a failing element of the hinge believed to be causing the most damage.

appleinsider.com logo
Oct 25 • 5:28 PM EDT • Technology • appleinsider.com
Novant Health hosting Hilton Head hiring event Oct. 28

Novant Health will host a healthcare hiring event Oct. 28 on Hilton Head Island for nursing, laboratory, pharmacy and other positions.

wtoc.com logo
Oct 25 • 5:22 PM EDT • Health • wtoc.com
😐 Neutral (2%)
love
100%
Cooper Health launches new mobile addiction and recovery program

The program will focus on high-need areas in the city and respond elsewhere when called, helping to connect people to addiction support services. | KYW Newsradio

audacy.com logo
Oct 25 • 5:17 PM EDT • Health • audacy.com
😐 Neutral (0%)
Jalen Coker not a big factor in Week 7

Panthers WR Jalen Coker caught only one of four targets in Week 7 and posted only nine yards

sports.yahoo.com logo
Oct 25 • 5:13 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
wow
100%
Is an Academy of Natural Sciences divorce coming?

Hearings for the museum are coming Monday. Will it make a difference?

inquirer.com logo
Oct 25 • 5:01 PM EDT • Science • inquirer.com
Volkswagen Bet On Xpeng To Save Its China Business, But Buyers Aren't Showing Up

Volkswagen once dominated China’s automotive market, but the rise of domestic electric vehicle manufacturers has turned its fortunes upside down. Hoping to regain lost ground, the German automaker partnered with Chinese EV specialist Xpeng in ... Read more

finance.yahoo.com logo
Oct 25 • 5:00 PM EDT • Business • finance.yahoo.com
U.S. measles cases more than double what they were last year as outbreak spreads

Pennsylvania is the worst hit state, with at least 1,338 cases of measles confirmed in 44 counties so far this year, according to the Pennsylvania Department of Health.

npr.org logo
Oct 25 • 4:35 PM EDT • Health • npr.org
Deep dive High-Signal Publisher
😐 Neutral (19%)
wow
100%
Mobile County Health Department updates sentinel chicken test

It concerned testing for St. Louis encephalitis

fox10tv.com logo
Oct 25 • 4:30 PM EDT • Health • fox10tv.com
☹️ Negative (-11%)
ahah
57%
love
43%
New Sistersville General Hospital marks milestone with final beam signing

Memorial Health System celebrated a milestone for the new Sistersville General Hospital with a final beam signing ahead of its 2027 opening, marking progress on expanded rural health care.

wtap.com logo
Oct 25 • 4:17 PM EDT • Health • wtap.com
😐 Neutral (15%)
wow
73%
ahah
27%
Brad Pitt's Underrated Sci-Fi Astronaut Movie Deserved Better At The Box Office

You likely missed this critically acclaimed Brad Pitt sci-fi thriller when it was in theaters, but it's a film that warrants a watch.

yahoo.com logo
Oct 25 • 4:17 PM EDT • Entertainment • yahoo.com
A YouTuber dissected an iPhone Duo and thinks he found the cause of crackgate

A weak spot in the hinge may be failing and cracking iPhone Duo screens.

theverge.com logo
Oct 25 • 4:16 PM EDT • Technology • theverge.com
How Pratt Proved Brewers Right in the World Series

Shrugging off an early error, rookie Cooper Pratt delivered a clutch game-winning hit, vindicating the Milwaukee Brewers long-term investment.

sports.yahoo.com logo
Oct 25 • 4:00 PM EDT • Sports • sports.yahoo.com
Germaphobe primates want to avoid getting sick, too

Some monkeys become significantly more cautious about food sources that appear contaminated after experiencing deadly outbreaks of disease.

seattletimes.com logo
Oct 25 • 4:00 PM EDT • Science • seattletimes.com
Rep. Carbajal Meets with Cottage Health’s Head Honchos in Santa Barbara as They Brace for ‘Big Beautiful Bill’ Impacts

Trump’s bill expected to leave close to 40,000 Central Coast residents without health coverage, another 37,000 with higher premiums, and a roughly $40 million initial impact on Cottage.

independent.com logo
Oct 25 • 3:30 PM EDT • Health • independent.com
Deep dive
😐 Neutral (13%)
wow
62%
love
38%
New heist movie starring Pete Davidson to finally hit theaters in November

Billed as ”Point Break" meets “Fast and Furious,” Davidson will share the silver screen with Nicholas Hoult and Zoë Kravitz.

silive.com logo
Oct 25 • 3:19 PM EDT • Entertainment • silive.com
New Braunfels Wurstfest ranks No. 1 in Southern Living list

Southern Living ranks this Texas Oktoberfest ahead of Fredericksburg.

mysanantonio.com logo
Oct 25 • 3:18 PM EDT • Entertainment • mysanantonio.com
Why is the U.S. accusing Canada of election interference?

the U.S. Embassy accused Canadian officials of meeting with Democratic lawmakers, urging the use of retaliatory levies to hit Republican states, and running anti-tariff political advertising.

inquirer.com logo
Oct 25 • 3:13 PM EDT • Politics • inquirer.com
NZ’s hidden chronic health burden is even bigger than we thought

New research reveals a major gap in how chronic illness is measured, with implications for planning and funding healthcare in New Zealand.

theconversation.com logo
Oct 25 • 3:10 PM EDT • Health • theconversation.com
Editorial: Company mergers are causing more harm to the entertainment industry than good

Two weeks ago, Paramount officially completed its $110 billion purchase of the historic Warner Bros.

videtteonline.com logo
Oct 25 • 3:09 PM EDT • Entertainment • videtteonline.com
Dodgers’ De Paula Faces Key Defensive Test

Josue De Paula impressed the Los Angeles Dodgers with his bat during his major-league debut. Can he do the same with his defense?

sports.yahoo.com logo
Oct 25 • 3:04 PM EDT • Sports • sports.yahoo.com
Asher Grunis steps down from leading Submarine Affair commission due to health concerns

Supreme Court President Isaac Amit appointed retired Supreme Court justice Zvi Zylbertal to replace Grunis and lead the commission on Sunday.

jpost.com logo
Oct 25 • 2:58 PM EDT • Health • jpost.com
☹️ Negative (-4%)
Freddy Peralta was beloved in Milwaukee. Now he stands in Brewers’ World Series path
sports.yahoo.com logo
Oct 25 • 2:48 PM EDT • Sports • sports.yahoo.com
Alaska Democratic Senate candidate Mary Peltola and her family suffer minor injuries in car crash

Alaska’s Democratic Senate candidate Mary Peltola and her family suffered minor injuries Saturday in a car crash while driving to a campaign stop, her campaign said.

news4jax.com logo
Oct 25 • 2:30 PM EDT • Politics • news4jax.com
Nigeria widens hunt for possible Ebola cases

Nigeria has widened a hunt for potential Ebola cases, with an additional nine contacts traced, health authorities said Sunday.The initial 44 contacts were health care workers, while the additional nin...

yahoo.com logo
Oct 25 • 2:26 PM EDT • Health • yahoo.com
Texas makes big moves in both polls

The win over the Rebels vaulted the Longhorns in the AP Top 25 and Coaches Poll.

sports.yahoo.com logo
Oct 25 • 2:19 PM EDT • Sports • sports.yahoo.com
‘There's a risk we do have a disconnect’: Business on Australian Labor

Chamber of Commerce CEO Andrew McKellar appears to suddenly be everywhere, all at once.

politico.com logo
Oct 25 • 2:15 PM EDT • Business • politico.com
Ramaswamy built his political career in NH. It's faltering in Ohio.

Many New Englanders remember Ramaswamy from his mad-dash presidential campaign in New Hampshire. Will his political career survive a tumultuous run for Ohio governor?

bostonglobe.com logo
Oct 25 • 2:13 PM EDT • Politics • bostonglobe.com
Inside 26-year-old’s club for million-dollar Chattanooga business owners

At 2nd American Restaurant on Thursday night, around 85 entrepreneurs who have scaled their businesses to at least $1 million in annual revenue sat to a family-style meal of beef cheek roast, airline chicken and the restaurant's signature bowl of mashed potatoes.

timesfreepress.com logo
Oct 25 • 2:01 PM EDT • Business • timesfreepress.com
Vegas gives Ole Miss double digit spread against visiting Auburn

Despite the loss to Texas, Ole Miss is heavily favored against Auburn

sports.yahoo.com logo
Oct 25 • 2:00 PM EDT • Sports • sports.yahoo.com
Blanche defends DOJ lawsuit blocking Alaska Senate results if Republican loses

Attorney General Todd Blanche defended the Justice Department's suit over Alaska's Senate race in an interview on CNN.

npr.org logo
Oct 25 • 1:50 PM EDT • Politics • npr.org
High-Signal Publisher
‘Clayface’ Ties ‘Obsession’ For A Rotten Tomatoes Audience Score Record

'Clayface' has a Rotten Tomatoes audience score that matches Obsession's a wild achievement for the comic book film.

yahoo.com logo
Oct 25 • 1:19 PM EDT • Entertainment • yahoo.com
Steelers Now Postgame: Steelers 16, Saints 10

Pittsburgh Steelers Postgame: Join Alan Saunders and Jobe Morrison after the Steelers’ Week 7 win over the Saints on YouTube, […]

sports.yahoo.com logo
Oct 25 • 1:18 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
ahah
100%
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KCBS All News 106.9FM and 740AM

audacy.com logo
Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KNSS Radio

audacy.com logo
Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

clickorlando.com logo
Oct 25 • 1:16 PM EDT • Entertainment • clickorlando.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KMBZ

audacy.com logo
Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

news4jax.com logo
Oct 25 • 1:16 PM EDT • Entertainment • news4jax.com
Clatsop County health inspections for September

Clatsop County health inspectors recently completed a round of restaurant inspections that yielded overwhelmingly positive results for most local eateries. But one Seaside establishment received a temporary closure after receiving […]

dailyastorian.com logo
Oct 25 • 1:10 PM EDT • Health • dailyastorian.com
Hunter's Moon 2026: All About October's Full Moon And What To Expect Tonight

The title "Hunter's Moon" dates back generations, originating in the Northern Hemisphere because it typically follows the harvest season.

ndtv.com logo
Oct 25 • 1:09 PM EDT • Science • ndtv.com
Senate rivals seek support from Alaska Native voters

The major candidates in Alaska’s U.S. Senate race are both casting themselves as strong voices on Alaska Native issues as they seek support from the key constituency ahead of the Nov. 3 election

latimes.com logo
Oct 25 • 1:03 PM EDT • Politics • latimes.com
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race

Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.

news4jax.com logo
Oct 25 • 12:49 PM EDT • Politics • news4jax.com
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race

Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.

ksat.com logo
Oct 25 • 12:49 PM EDT • Politics • ksat.com
Police: Lancaster County health care worker assaulted

Incident occurred at WellSpan Hospital in Ephrata Borough, according to police.

wgal.com logo
Oct 25 • 12:42 PM EDT • Health • wgal.com
Orlando Science Center hosts Halloween party

Adults can enjoy an open bar, laser shows, and more at the Orlando Science Center's Halloween After Dark on October 31.

wftv.com logo
Oct 25 • 12:32 PM EDT • Science • wftv.com
Warriors honor Bay Area sports reporter Michael Wagaman

After Michael Wagaman passed away in early August, Dallas Braden took time to tribute him during his call of the Athletics’ game on NBC Sports Bay Area and California. Wagaman had covered Bay Area sports teams since 1996, including for the Associated Press, and freelanced for NBC Sports Bay Area and California at the time…

sports.yahoo.com logo
Oct 25 • 12:30 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Health care shakes up the Iowa election

If Democrats flip Congress, health care could find its way to the top of their 2027 agenda.

politico.com logo
Oct 25 • 12:26 PM EDT • Health • politico.com
Kansas at Duke: Exhibition OGT

Kansas basketball hopes to follow the football team with a win today. Yeah, this game doesn’t count, but any time you’re playing Duke you want to win. Plus, this exhibition game is a big enough deal that ESPN is broadcasting it live (probably because they know everyone else will be watching football. I’m probably going […]

sports.yahoo.com logo
Oct 25 • 12:21 PM EDT • Sports • sports.yahoo.com
😐 Neutral (6%)
wow
100%
Photographer and medical professionals connect science and art during panel discussion

In 2020, the world was put on hold because COVID-19 began claiming the lives of people all over the globe. When a vaccination for the illness was finally made public in 2021, being vaccinated became highly politicized. Instead of focusing on the emotional reactions that people had toward the vaccine, artist Linda Alterwitz was more...

thesunflower.com logo
Oct 25 • 12:14 PM EDT • Science • thesunflower.com
Deep dive
😐 Neutral (14%)
wow
43%
ahah
29%
love
28%
Lycia Lands a $317M IPO for Inflammation Drugs Based on Nobel Prize-Winning Science

Lycia Therapeutics’ protein-degrading drugs are based on the research of Carolyn Bertozzi, a Stanford chemistry professor and Nobel laureate. Lycia’s lead drug candidate is in development for food allergy, where it could compete against the blockbuster Roche drug Xolair.

medcitynews.com logo
Oct 25 • 12:13 PM EDT • Science • medcitynews.com
Memorial Health celebrates staff with trunk-or-treat

Memorial Health went all out for its annual trunk-or-treat event, celebrating team members and their families.

kswo.com logo
Oct 25 • 12:13 PM EDT • Health • kswo.com
😐 Neutral (9%)
wow
100%
Bloomington business continues to blossom

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insideindianabusiness.com logo
Oct 25 • 12:11 PM EDT • Business • insideindianabusiness.com
😐 Neutral (0%)
Texas opens as heavy favorite against Mississippi State

The Longhorns are three-score favorite as they welcome the Bulldogs to Austin.

sports.yahoo.com logo
Oct 25 • 12:10 PM EDT • Sports • sports.yahoo.com
😐 Neutral (9%)
In West Maui, Democrat-turned-Republican defends House seat against Lahaina Strong organizer, local business advocate

Incumbent Rep. Elle Cochran, Green Party candidate Pā’ele Kiakona and Democratic nominee Sne Patel are battling to represent West Maui at a pivotal time in the fire recovery.

mauinow.com logo
Oct 25 • 12:01 PM EDT • Business • mauinow.com
Is having urine the color of Mountain Dew normal?

A Trump administration doctor says neon yellow urine is normal because of diets consisting entirely of meat and fermented foods. Here’s what experts say

health.yahoo.com logo
Oct 25 • 12:00 PM EDT • Health • health.yahoo.com
😐 Neutral (12%)
wow
57%
ahah
43%
Americans have a grief problem we still call a mental health problem

OPINION — Americans have become much better at talking about mental health. We have learned words such as trauma, post-traumatic stress disorder, depression, anxiety, burnout, compassion fatigue and moral injury. That vocabulary matters.

yourvalley.net logo
Oct 25 • 12:00 PM EDT • Health • yourvalley.net
Trick-or-treaters descend on Callow Avenue for Calloween

Photos from Charleston Business District's annual Calloween event on Saturday, Oct. 24. ·

kitsapsun.com logo
Oct 25 • 11:57 AM EDT • Business • kitsapsun.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Nonprofit organizes ‘silkies’ hike to support military members’ mental health

During the hike, participants wore military short-shorts known as “silkies” as part of the event’s tradition to foster connection.

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Oct 25 • 11:27 AM EDT • Health • wpxi.com
Nonprofit organizes ‘silkies’ hike to support military members’ mental health

Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.

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Oct 25 • 11:27 AM EDT • Health • wpxi.com
Google's next TV gadget may do much more than stream

A reported hardware overhaul could bring Gemini further into the living room.

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Oct 25 • 11:17 AM EDT • Technology • thestreet.com
Florida political leaders mourn after shooting at FAMU homecoming

Florida politicians express grief after a shooting near FAMU homecoming festivities injured multiple people.

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Oct 25 • 11:15 AM EDT • Politics • tallahassee.com
Rumored Lucia Actress Goes Viral After Dodging Swarm of GTA 6 Comments During Livestream

Manni L. Perez, the actress long rumored to be playing Lucia in GTA 6, has gone viral after dodging a swarm of comments from Grand Theft Auto fans during a recent livestream.

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Oct 25 • 11:14 AM EDT • Technology • ign.com
Their friend died of cervical cancer in 2020. Now, they advocate for women’s health in N.S.

Following the death of their close friend from cervical cancer in 2020, two women in Nova Scotia were left wondering how things might have been different had she been diagnosed earlier. Six years later, they have raised over $4 million to improve technology and infrastructure for women's health.

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Oct 25 • 11:05 AM EDT • Health • cbc.ca
MCHD: Several people treated at local emergency rooms for bat bites in Baldwin County

The Mobile County Health Department says the patients were bitten at different residences in Baldwin County.

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Oct 25 • 11:00 AM EDT • Health • fox10tv.com
Laramie County health and food inspections (10/16/26–10/22/26)

CHEYENNE, Wyo. — The Cheyenne-Laramie County Health Department inspects restaurants, bars, convenience stores, delis, grocery stores, bed and breakfasts

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Oct 25 • 11:00 AM EDT • Health • capcity.news
Natrona County health and food inspections (10/16/26–10/22/26)

CASPER, Wyo. — The Casper-Natrona County Health Department inspects restaurants, grocery stores, convenience stores, mobile food units, commissaries and

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Oct 25 • 11:00 AM EDT • Health • oilcity.news
Michigan Gov. Gretchen Whitmer says America is ready to elect a Woman

The Michigan governor did not deny that she was exploring a potential run for president in 2028.

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Oct 25 • 10:56 AM EDT • Politics • nbcnews.com
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University of Rochester Medicine Home Healthcare holds inaugural Hospice 5K

13WHAM ABC Rochester provides local news, weather forecasts, traffic updates, health reports, notices of events and items of interest in the community, local sports and entertainment programming for Rochester and nearby towns and communities including Greece, Victor, Pittsford, Penfield, Henrietta, Webster, Irondequoit, Fairport, Chili, Gates, Rush, Wheatland, Canandaigua, Farmington, Spencerport and Hilton.

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Oct 25 • 10:44 AM EDT • Health • 13wham.com
After Fighting in Gaza and Battling PTSD, Shahar Varon Seeks a Voice In Israel's Mental Health Future

Soldiers and others suffering from post-traumatic stress disorder […]

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Oct 25 • 10:41 AM EDT • Health • themedialine.org
October 7 should have changed Israeli politics, yet we are voting for the same leaders

Israel deserves more than another election between yesterday’s failures. It deserves a new beginning.

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Oct 25 • 10:36 AM EDT • Politics • jpost.com
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Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign

Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.

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Oct 25 • 10:35 AM EDT • Politics • pbs.org
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean

Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...

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Oct 25 • 10:08 AM EDT • Health • finance.yahoo.com
After long, strange trip, Compass CEO nears launch of psilocybin pill

Compass Pathways is on the cusp of FDA approval for a proprietary version of psilocybin — the active drug in magic mushrooms.

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Oct 25 • 10:07 AM EDT • Business • businessinsider.com
Can social media bans protect young people’s mental health? Early research suggests that bans aren’t the answer

About 20 countries are looking to ban minors from social media. But bans have not always worked as planned. Here are some other ideas to make platforms safer for kids.

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Oct 25 • 10:01 AM EDT • Health • inquirer.com