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Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
Packers Lose Defensive Captain Just Before Massive Showdown With Lions
Green Bay Packers defensive captain Zaire Franklin has been ruled out against the Detroit Lions, leaving Green Bay without both starting linebackers.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
Jennifer Hawks explains why she should be California's State Treasurer
Jennifer Hawks, a candidate for California state treasurer, shared her qualifications and vision for the office in an interview on California Politics 360.
Senator, former California Secretary of State Alex Padilla weighs in on voter roll fight
With one week left before the midterm elections, California is facing a federal lawsuit alleging that non-citizens were registered to vote, received mail-in ballots, and, in some cases, voted.
Who can buy California's voter rolls and why?
Chris Micheli, an adjunct professor at McGeorge School of Law and longtime lobbyist, explained who is able to buy the voter rolls and why in an interview on California Politics 360.
Timeline of the Capitol Annex project
Ashley Zavala looked back at the decade-long process of building the new offices for the governor and state lawmakers.
California Politics 360 full episode | Clash over voter rolls heads to court
On Tuesday, one week before the election, a federal judge will determine the next steps.
Syria’s Democratic Transition: Building Institutions Alongside Political Competition
Syria’s post-Assad transition has revived debate over when to legalize political parties. Parties are essential to political competition,
Florida political leaders mourn after shooting at FAMU homecoming
Florida politicians express grief after a shooting near FAMU homecoming festivities injured multiple people.
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit
As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...
On Christ the King and the idolatry of politics
Editor’s note: This homily was preached on the feast of Christ the King (Extraordinary Form), October 25, 2026, at the Church of the Holy Innocents, New York City. In the calendar of the Usus Antiquior, […]
Stateliner Pride on Display: Phillipsburg Band and Alumni Unite at Halftime
Phillipsburg’s Stateliner band and alumni joined for a halftime performance celebrating school tradition, pride and community at Friday’s football game.
Three Days Grace in San Antonio: What to know
The Canadian rockers are bringing their Alienation Tour to town. Here are the details on tickets, parking and more.
Scientists Found One of The 'Chunkiest' Squid-Like Creatures Ever Known
A "thick and peculiar" cephalopod.
MCHD: Several people treated at local emergency rooms for bat bites in Baldwin County
The Mobile County Health Department says the patients were bitten at different residences in Baldwin County.
GO Health asks families to be lead-aware
BATAVIA — Area health departments are encouraging families to get the facts and get their children and homes tested for National Lead Poisoning Prevention Week.
Campbell County health and food inspections (10/16/26–10/22/26)
GILLETTE, Wyo. — The Consumer Health Services Division of the Wyoming Department of Agriculture conducts inspections of retail food establishments throughout Wyoming (where there is not a local health department that does inspections) to help ensure safety of Wyoming residents. Campbell County establishments are inspected at least once a year by the WDA. All of […]
Laramie County health and food inspections (10/16/26–10/22/26)
CHEYENNE, Wyo. — The Cheyenne-Laramie County Health Department inspects restaurants, bars, convenience stores, delis, grocery stores, bed and breakfasts
Natrona County health and food inspections (10/16/26–10/22/26)
CASPER, Wyo. — The Casper-Natrona County Health Department inspects restaurants, grocery stores, convenience stores, mobile food units, commissaries and
Little Rock health fair connects Arkansans with screenings and preventive care
KATV ABC 7 in Little Rock, Arkansas covers news, sports, weather and the local community in the city and the surrounding area, including Hot Springs, Conway, Pine Bluff, Jacksonville, Sherwood, Stuttgart, Benton, Bauxite, East End, Scott, Pinnacle, Maumelle, Gibson, Landmark and Hensley.
AI-generated video heats up suburban Texas political clash
Fort Bend County has seen plenty of controversy at its highest levels.
Michigan Gov. Gretchen Whitmer says America is ready to elect a Woman
The Michigan governor did not deny that she was exploring a potential run for president in 2028.
What Chelsea Did Wrong vs Tottenham
After a stellar run following the international break, things came crashing down for Chelsea as they lost 2-0 to Tottenham Hotspur at the weekend. This marked an extremely rare defeat at Stamford Bridge to the Lilywhites, a crack in a strong record of home wins that has left fans reeling. In this, we will be …
Micron Just Revealed a New Business Strategy. That Change Makes It a Screaming Buy.
Micron is changing more toward contracts, rather than letting the open market dictate pricing.
Face the Facts: New health insurance helps early childhood educators
Child care is expensive, and keeping qualified workers on the job is part of the challenge. Now, Connecticut is offering a new health insurance subsidy to help early childhood educators lower their monthly premiums. Rep. Kate Farrar (D-West Hartford) explains how it works and why it could make a difference for families. Mike Hydeck: For years, Connecticut has had among…
Aaron Rodgers passes Peyton Manning on all-time touchdowns list
Aaron Rodgers surpasses Peyton Manning in all-time touchdown passes.
After Fighting in Gaza and Battling PTSD, Shahar Varon Seeks a Voice In Israel's Mental Health Future
Soldiers and others suffering from post-traumatic stress disorder […]
October 7 should have changed Israeli politics, yet we are voting for the same leaders
Israel deserves more than another election between yesterday’s failures. It deserves a new beginning.
Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign
Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.
World's Fastest Lawnmower Company Is Officially Going Out Of Business
Dixie Chopper made the world's raddest lawnmowers for almost half a century, but its story is now coming to an end.
Grading Iowa Football's Loss To Minnesota
This may have been Iowa's worst quarterback performance since the dreadful 2023 season.
Mavericks 'Very, Very Confident' in Rookie PG Behind Kyrie Irving
Spanish sensation Sergio de Larrea shined with 21 points against San Antonio, proving he can anchor the rotation while Dallas carefully manages Kyrie Irving’s heavy workload.
10 Thoughts From Watching Others Sweat It Out
Back during the very lean years of the Ray Goff era in Athens, a certain revered columnist for the Macon Telegraph joked in a weekly prediction column that Georgia would lose to “Open” during its upcoming bye week. Thankfully, those years have passed by, and the outlook for Georgia during open weeks for what is […]
NFL Trade Deadline Could Dramatically Change The AFC South Landscape
With top stars from the Titans, Colts, and Jaguars hitting the trade block, Houston’s rivals could strip their rosters of veteran talent to fuel a mid-season rebuild.
NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say
A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…
Arch Manning has another viral moment with ESPN's Holly Rowe
The Texas quarterback was happy to see Rowe on the sidelines.
Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks
The Boston Celtics beat the New York Knicks 107-103 on Friday night at TD Garden. Jayson Tatum scored 36 points and closed the game with a run that sealed the win. The stat line told the obvious story.But after the game, the moment Tatum wanted to talk about was not one of his own. It […] The post Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks appeared first on HEAVY.
Some Thoughts About Ron Duguay
Dear, departed Ron Duguay was not anything like his playboy image.
Amid first 0-3 start since 2007, Giannis-led Heat searching for answers: ‘We’re not in panic mode’
The Heat’s Giannis Antetokounmpo era is off to a rough start.
Preview
The Men's First Team are back in Serie A action, this time heading south to face Lecce in Puglia.The Serie A Matchday 8 clash is set to take place at the Stadio Via del Mare at 18:00 CET on Sunday, Oc...
Oprah on the Health Metric We Should All Be Tracking
“These facts are a wakeup call for all of us to get serious about our heart health.”
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean
Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...
After long, strange trip, Compass CEO nears launch of psilocybin pill
Compass Pathways is on the cusp of FDA approval for a proprietary version of psilocybin — the active drug in magic mushrooms.
Ranked: Countries With the Most Trust in Science
Discover which countries trust science the most and least in 2025, and how education, religion, and culture shape public confidence.
Michigan's Jason Beck promised change, but numbers tell another story
Michigan football vowed to fix its perimeter run game or stop it, but the team continues to struggle on the edge.
Roots music fest fun in downtown Yadkinville
Click here to view this article from yadkinripple.com.
Can social media bans protect young people’s mental health? Early research suggests that bans aren’t the answer
About 20 countries are looking to ban minors from social media. But bans have not always worked as planned. Here are some other ideas to make platforms safer for kids.
Halifax Health Sees 19 Biketoberfest-Related Injuries in 2026
With Biketoberfest 2026 having ended on October 18, Daytona Beach’s Halifax Health Medical Center announced the statistics on injuries related to the event. 19 patients were treated for injuries …
17 Celebrity Transformations That Left Fans Doing A Double Take
From Avril Lavigne's “soft makeup era” to JoJo Siwa’s “clean girl” aesthetic, these wild celebrity transformations will leave you gagged.
Silicon Valley software engineer pay ranked against other US cities
Bay Area software engineers retain a 53% pay premium after adjusting for local prices, Levels.fyi found. Taxes aren't included.
Stop Chasing Views: How 87% of Creators Are Using AI to Build Real Businesses Beyond Social Media
87% of creators say AI is growing their business. Here's how creators trade social media algorithms for owned commerce and real enterprises.
Inside California Politics: State Senate candidate John Erickson
(Inside California Politics) — California’s top-two primary system often leads to same-party general election races, often between two Democrats, and this year is no exception. Two weeks ago on Inside...
LETTER TO THE EDITOR: Misleading political mailer is a smear campaign
The recent misleading smear mailer by the opponents of Denise Krause in the Oregon Senate campaign is the most disgusting exhibit of money and indecency used to capture uninformed voters’ […]
31 'Brooklyn Nine-Nine' Memes That Would Win a Halloween Heist and Become the Ultimate Detective/Genius
These memes are noice!
Nuthatches are rude: Ornithological observations from a recliner
I don’t know what age you’re supposed to start sitting in a recliner and looking out the living room window at the bird feeder, but I sure do like doing
Manchester United vs Bournemouth: Live updates from Old Trafford
Under-fire Manchester United manager Michael Carrick is under enormous pressure heading into today’s Premier League clash with Bournemouth on the back of a seven-game run without a win.The boss has ...
Culture House Wants to Turn Creator Connections Into Lasting Businesses
Culture House connects creators directly with investors and operators, helping turn cultural influence into sustainable businesses.
Nick Nurse: “Jaylen Brown is obviously very good. He …
Nick Nurse: “Jaylen Brown is obviously very good. He …
Evan Mobley on Jarrett Allen: “The team loves it. …
Evan Mobley on Jarrett Allen: “The team loves it. …
Khaman Maluach: “It’s different. Draymond Green is …
Khaman Maluach: “It’s different. Draymond Green is …
"I mean, stuff happens. It's a business. It's not in …
"I mean, stuff happens. It's a business. It's not in …
"I mean, stuff happens. It's a business. It's not in …
"I mean, stuff happens. It's a business. It's not in …
"Jakucionis, he's family. He's an incredible player," …
"Jakucionis, he's family. He's an incredible player," …
Maliek Collins agrees to terms on contract extension
Maliek Collins to remain in Cleveland for two additional years
Investment driving growth at NWS Crane
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Hints About Why Sabres Missed Connor Hellebuyck
The fact that the Buffalo Sabres missed out on Connor Hellebuyck could linger painfully for a while if the goalie play in Western New York doesn’t improve in a hurry. It’ll hurt all the more because the reports over the summer indicated that for at least a time, the Sabres were the frontrunners to pull […] The post Hints About Why Sabres Missed Connor Hellebuyck appeared first on HEAVY.
Former Coach Urges Vikings to Blow Up Kyler Murray Experiment; Trade for… Kirk Cousins?
Jon Gruden has an insane trade idea for the 5-0 Minnesota Vikings and involves a quarterback change that nobody would see coming...
Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
I'm 62 and refuse to dress or act my age
Lonni Pike got sober at 51 and reinvented her life. Now 62, she's a fashion influencer, gamer, and advocate for aging on her own terms.
Denzel Ward to take part in pregame warmups
Denzel Ward's status for Week 7 remains in question
Science Snapshots: October 25, 2026
Three key science updates in one minute: Starry Night’s dawn matched to Jul 22, 1889; cold boosts lifespan via BH2/BH4; cluster similar-buildings cools cities.
Crystal Palace v Chelsea
Follow live text commentary, score updates and match stats from Crystal Palace vs Chelsea in the Women's Super League
Fernandes dropped: Man United name team to face Bournemouth
Manchester United have named their team to face Bournemouth in the Premier League, with captain Bruno Fernandes dropped from the side.Fernandes has been named among the substitutes at Old Trafford, in...
Clemson HC Dabo Swinney Waving White Flag on Season
Following a humbling loss to Virginia Tech, Dabo Swinney is recalibrating expectations as the Tigers abandon playoff dreams and fight to salvage a disappointing, sub-par season.
Liverpool host Brighton; Man Utd take on Bournemouth in PL
2026-10-25T13:33:41ZA rundown of today's games...2pm kick-offs:Liverpool vs BrightonManchester United vs BournemouthHull City vs BrentfordCrystal Palace vs Newcastle4:30pm kick-off:Sunderland vs Leeds...
Health board still paying for research despite criticism over patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
Health board still paying for research with 'unclear' patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
Ranking Ohio State’s remaining games from easiest to hardest
With Julian Sayin out indefinitely, Ohio State’s final five games will define their playoff hopes. Here’s how those opponents rank, from easiest to toughest
NFL Week 7 expert picks, score predictions: Packers at Lions
Green Bay Packers vs. Detroit Lions NFL Week 7 expert picks from the Pride of Detroit staff.
IU Health’s new downtown medical campus has a name and an opening date
By Daniel Bradley | Indianapolis Business Journal
'All INdiana Politics': Engling, Ballard clash over restoring credibility to Indiana Secretary of State Office
INDIANAPOLIS — On Sunday’s edition of “All INdiana Politics,” Government Reporter Garrett Bergquist sat down with two candidates who are running for secretary of state, Republican Max Engling and independent Greg Ballard. Both candidates outlined contrasting approaches to restore credibility to an office plagued by controversy under outgoing Secretary Diego Morales. They both presented different […]
Saints vs. Steelers in Paris: Week 7 game chat
The Saints face the Steelers in this Week 7 matchup. Join us here for the game!
Argument over purchase turns physical; suspect pulls gun at South Side business
WOAI NBC News Channel 4 San Antonio provides local news, weather forecasts, traffic updates, investigations, and items of interest in the community, sports and entertainment programming for San Antonio and nearby towns and communities in South Central Texas, including Windcrest, Uvalde, Universal City, Somerset, Seguin, Schertz, San Marcos, Sabinal, Poth, Poteet, Pleasanton, Pearsall, New Braunfels, Live Oak, Kerrville, Hondo, Helotes, Goliad, Fredericksburg, Floresville, Eagle Pass, Devine, Del Rio, Cuero, Crystal City, Converse, Cibolo, Castroville, Carrizo Springs, Boerne, Bandera.
r/opensource just banned AI, non-English speakers and more
The opensource subreddit’s new rules against AI have sparked a revolt.
Week 7 Early Games Open Thread
The only games I’m really keyed in on are the Steelers and Texans both losing to the NFC team and then decided which team between the Bengals and Ravens are the bigger threat to Denver’s future playoff seeding arrangement. Here are the games we have to watch today before the Denver Broncos take on the […]
Physician Mental Health and Health System Privacy: Why Doctors Avoid Their Own EHR
In most organizations the default access model was built for patient care, not for protecting colleagues. A nurse on another unit, a resident who rotated with them, a department administrator: any of them may technically be able to open the record, even when policy says they should not.
Appleton-area high school sports results for Saturday, Oct. 24
High school tennis, volleyball, soccer and cross-country teams were in action.
Adam Schiff responds to DOJ’s Alaska threat: ‘it’s Alaska’s business’ to run elections
In an exclusive interview with Meet the Press, Sen. Adam Schiff (D-Calif.) says “it's not the federal government's business to run Alaskan elections,” after the Justice Department sued to block certification of Alaska’s election results if Sen. Dan Sullivan loses, due to another candidate with the same name appearing on the ballot.
NFL Week 7 Game Discussion and Open Thread
Talk about all the Week 7 NFL games with us here!
Taylor Dayne Trades L.A. for Coastal Sanctuary After Health Battle
The pop icon has traded the hustle of Los Angeles for a new life in Santa Barbara after recovering from a harrowing battle with colon cancer.
Business co-owner kills man ‘acting irrationally’ outside Zumba class, NC police say
The business co-owner was carrying a firearm, Spindale police say.
Colts vs. Vikings
Here is how the ColtsRoundtable staff sees the Week 7 matchup between the Indianapolis Colts and Minnesota Vikings unfolding.