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Radio telescopes help scientists map molecules in space and uncover where and how stars form
Interstellar maps can help scientists find patterns that tell them about fundamental chemical processes in the cosmos.
Hubble vs Roman
NASA's Hubble and Roman space telescopes will work together to broaden our perspective of the universe.
Health advocacy group sues AMA to make billing codes public
PatientRightsAdvocate.org is challenging the doctor’s association’s copyright of the current procedural terminology, or CPT, system. Use of the codes is required by law, and that means they should be freely available, per the suit.
Trump to rally with New York police in highlighting historic coast-to-coast violent crime drop
President Donald Trump travels to Nassau County Police Academy with Todd Blanche and Kash Patel to rally with cops and tout historic crime drop.
Microsoft kills off unsuccessful AI features while merging its separate Copilot apps
Microsoft is simplifying Copilot by combining its consumer and business apps, and dropping AI-generated podcasts, Group Chats, Deep Research, and its Mico character.
AI needs science’s search history
“Actually, that’s where the gold is,” said Alasdair Russell, my graduate school friend who leads a pre-clinical genome editing group at Cambridge. He was talking about the winding road of science that is omitted from published papers. “When you’re discussing how to do the experiment, and why this way is better than another way, and what does the data really mean? I know what it shows, but what does it mean?” At RAAIS 2026, he described how his group has begun logging the twisting path of discovery as it happens, recording the verbal and written exchanges that normally disappear. Ideas become nodes in a living graph: they branch when a meeting produces two plausible experiments, merge when separate lines of evidence converge, and go dark when someone quietly stops pursuing them. In his implementation, one agent scores novelty, while another tries to learn “how scientists think and how they navigate through a complex world of data,” so that high-potential nodes can trigger deeper investigation. As frontier AI labs deploy agents toward scientific discovery, giving AI authentic scientific taste remains a trillion-dollar dilemma. The bottleneck is that the record we have kept for centuries of science might be insufficient to get us there. The experiments that never make the paper Peter Medawar, 1960 Nobel laureate and “father of transplantation,” asked in 1963 whether the scientific paper was a fraud, and answered yes: the form of the paper misrepresents the thinking that produced it. Sixty years on, the diagnosis is unchanged. A paper presents a clean progression from hypothesis to result to conclusion. Lost along the way are the unconventional theories, the abandoned or unaffordable methods, and the underwhelming and inconclusive data. It reads like a browser history with every dead end deleted: the ten open tabs, the four rephrased queries, the wrong turn down a subforum. All scrubbed, leaving one clean path from question to answer as the canonical path. What has changed since then is that the discarded material is now worth something. No high-impact journal wants these artifacts, but raw trial and error is the most likely source of the training data required to develop scientific intuition, or what researchers call taste. Earlier attempts to capture the discards were motivated by scientific integrity. The Journal of Negative Results in Biomedicine launched in 2002 to publish rigorous studies that disputed established models or exposed ineffective treatments. Its archive preserved negative conclusions after they had become papers, rather than the live alternatives and arguments that produced them. BioMed Central closed it in 2017, saying the mission had been served now that other journals publish null results. A less generous reading is that in fifteen years it published around 200 papers because almost nobody wants to read a negative result, let alone write one up when it will not count toward academic tenure. AI models are different. Even an uninteresting negative result can be useful, provided it is labeled. Earlier this year, Anthropic put a version of this to the test. The company pulled 129 decision points from real Claude Code sessions between January and March 2026, showed models the work up to a human detour, and asked what should happen next. Claude Mythos Preview beat the human choice 64% of the time, while Opus 4.5 managed 51%. The comparison was tilted toward the models because Anthropic deliberately chose moments where the human decision had room for improvement. On 127 further scenarios where the human action was already strong, the models improved on it only about 20% of the time. The study was possible because Anthropic’s researchers work inside a tool that logs by default. The reasoning, detours and outcome are produced in the same working environment. Biology has no equivalent. Its reasoning happens in hallways, at benches, in Slack threads and on whiteboards, while the outcome arrives weeks later somewhere else. The record has to emerge from the work itself. Ask scientists to reconstruct it afterwards and we’ll create another polished account. Subscribe A log is not a label Before any of this becomes training data, a negative result has to say what failed. The first paper published in the Journal of Negative Results in Biomedicine examined 234 negative studies across five leading medical journals. Only 30% discussed statistical power, and half clearly defined a primary outcome. Tell a model an experiment failed, without telling it whether the assay was underpowered, a reagent had degraded, or the hypothesis was simply wrong, and it will learn noise with confidence. Decision histories have a second missing label too. When a lab considers five experiments and runs one, only the chosen branch returns an outcome. The other four are experimental counterfactuals. Researchers call this the selective labels problem: the data reveal results only for the actions someone chose to take. Such a record can teach a model to imitate a lab’s taste, but it cannot establish that the taste was good. It also smuggles local constraints into general lessons. A lab that never ran cryo-EM because it did not own a microscope teaches a model that cryo-EM is rarely the right call. Alasdair’s nodes preserve the candidate set, which is the necessary first step. To be useful, each decision record needs six fields: The evidence available at that moment, and nothing that arrived later. The candidates considered, including the ones dismissed in a sentence. For each candidate: the expected result, the confidence attached to it, and the cost in time and money. The route chosen, and the reason. What happened next. How the evidence changed the scientist’s view. These must be timestamped before the outcome, because hindsight turns uncertainty into inevitability. Disagreement also has to survive. Averaging three scientists into one clean rationale reproduces exactly the information loss we are trying to fix. But there is an obvious failure mode here. Once decisions are logged and scored, people log for the record post-facto. Anyone who has watched an electronic lab notebook fill up with retrospective tidying knows how quickly a research tool becomes a compliance exercise. A record that costs a scientist ten minutes of honest reflection per decision is worth far more than one that costs an hour of performance. A publication initiative called Registered Reports offers a useful starting point. Here, researchers submit their rationale, methods and analysis plan for peer review before the data exist, and the journal commits in principle to publish if they follow the approved plan. Nature has now expanded the format across every field it covers. This approach to paper writing timestamps intent before the outcome, but it freezes one plan. A useful search history must also preserve how the plan changed, which alternatives were rejected, when, and on what evidence. Subscribe Run the runner-up Autonomous labs show what happens when decisions and outcomes are connected in a loop. Liverpool’s mobile robotic chemist ran 688 experiments over eight days in a ten-variable formulation space. A batched Bayesian search used each result to choose the next experiments and found photocatalyst mixtures six times more active than the starting formulations. Every completed experiment changed what the system did next. The robot optimized within a goal and search space that humans had already chosen. It did not decide which scientific question mattered. So what this work demonstrates is narrower, but still useful: a search history pays off when the options return standardized outcomes quickly. Open-ended biology is harder because branches can take weeks and the discarded alternatives may never be run. Some exploration therefore has to be bought. Where two branches are plausible and the stakes justify the cost, a lab should sometimes run the runner-up. Otherwise the record captures what today’s scientists usually chose and stays silent on what they systematically overlooked. A funder could ring-fence a small fraction of a grant for the branch not taken, provided that the decision record and the outcome are both deposited. That costs money, but so does having every lab rediscover the same abandoned path. Test whether taste transfers When it comes time to evaluate if our new AI system exhibits taste, the comparison should run across laboratories and fields. At selected decision points in a live research campaign, we should freeze the six fields: the evidence, the candidates, expected results, confidence, costs and the choice made. Experts then rank the options before the outcomes are known, and those outcomes are checked independently later. We could give models one of two diets - papers alone, or papers plus decision histories - and ask them to rank the next experiment on unfamiliar projects. Then, we score information gained per dollar and week, calibration, and how quickly weak branches are abandoned. If histories improve choices only inside the lab that produced them, they amount to useful organizational memory. If they improve choices on unfamiliar problems elsewhere, Alasdair’s group will have captured something science has never managed to write down: a transferable record of taste. Until that happens, a scientific search history is a promising record, not yet a training set.
24 Years Later, Nintendo’s Most Divisive Game Officially Returns to Switch 2 Better Than Ever
It still shines to this day
Microsoft starts merging its Copilot consumer and business apps in advance of ‘Super App’ rollout
Microsoft is combining its consumer and business Copilot apps into a single app, in a gradual transition starting this week. Copilot Podcasts, Group Chat and Deep Research will be retired beginning Aug. 18, along with Mico, the animated character added to Copilot's voice mode last year.
Microsoft starts merging its Copilot consumer and business apps in advance of ‘Super App’ rollout
Microsoft is combining its consumer and business Copilot apps into a single app, in a gradual transition starting this week. Copilot Podcasts, Group Chat and Deep Research will be retired beginning Aug. 18, along with Mico, the animated character added to Copilot's voice mode last year.
Ask a Scientist: How Do We Track the Trump Administration’s Attacks on Science?
Introducing a multi-purpose tool for documenting AND fighting attacks on science that affect our health and safety.
Dogs know if we’re happy, sad or scared just from our expressions, study suggests
It’s something every dog owner knows — but now we have the science to prove it: Dogs really can tell when we’re happy or sad.
Jayden Daniels Takes Legal Action Against Louisiana State
The Louisiana State Tigers are one of the most successful football programs in the nation.LSU is one of few other programs that have yielded multiple Heisman Trophy victors. Unfortunately, it appears as if they find themselves on less-than-ideal terms with one of the winners.ESPN obtained a copy of a letter sent by Jayden Daniels‘ legal […] The post Jayden Daniels Takes Legal Action Against Louisiana State appeared first on HEAVY.
Wonderscope Children’s Museum hosts NASCAR ‘Science of Speed’ event
The Regnier Family Wonderscope Children’s Museum of Kansas City hosted a “Science of Speed” event Tuesday in partnership with Kansas Speedway and NASCAR, offering families hands-on STEAM activities tied to motorsports.
NYC Health + Hospitals/Jacobi | North Central Bronx Receives $600,000 for New Ophthalmology Microscope
NYC Health + Hospitals/Jacobi | North Central Bronx CEO Christopher Mastromano announced today that, thanks to the generous support of Borough President
Building Science fellowships give UMaine students real-world experience engineering solutions for Maine companies
Under a microscope at TimberHP’s manufacturing plant in Madison, Maine, Brian Waterbury studied plant fibers used to make insulation for homes while learning how engineers solve problems. Waterbury, a University of Maine senior from Topsham, Maine, who is majoring in chemical engineering, works as a quality control and process engineer…
Sports on TV for Aug. 17
ADV15-16 (All times Eastern) Schedule subject to change and/or blackouts Monday, Aug. 17 4 p.m.
Rice launches SCOPE, a new science communication center
The Center for Science Communication and Public Engagement (SCOPE) is now open at Rice.
Meccha Chameleon has now sold 20 million copies in two months
Do you want to calculate how much revenue that would be?
Telescope Spots Two Black Holes on the Cusp of Merging
New images from the James Webb telescope show a galaxy with a trio of supermassive black holes. Two of them appear to be locked in a tight tango.
Lexington County could take on $74 million in debt for a sports complex
The Lexington County Recreation Commission is proposing a multi-sports complex off Interstate 77, but there are questions about how it will be paid for.
📸 Horrific injury in the Copa Libertadores
Tiago Palacios suffered a chilling injury in the match between Estudiantes and Universidad Católica in the Copa Libertadores Round of 16.The Estudiantes player ended up with a huge lump on his face a...
Astronomers created the largest-ever 2D map of the universe, charting 4 billion objects in the night sky
A new celestial map not only catalogs a variety of cosmic objects but also serves as a pointer for other telescopes on Earth and in space.
Intertidal: Bioluminescence is science, but still feels like magic
In the long days of summer, there is so much light that darkness holds a special magic. One of my favorite things to do on summer evenings is to be out in the darkness. And some of the most magical things about summer's darkness are the unexpected lights.
Business Process Catalog Available in Dynamics 365 Implementation Portal
Explore business process visualization in the Dynamics 365 Implementation Portal to align stakeholders, define scope, and improve implementation planning.
2026 40 Under 40 includes standouts in tech, health care, aviation and finance
The Tampa Bay Business Journal honors 40 business leaders under 40 making an impact across the seven-county area in its annual recognition program.
New images of the sun show its surface in the finest detail yet
It’s dangerous to look directly at the sun without proper eye protection. But researchers were able to peek at its scorching surface with the help of the National Science Foundation’s Daniel K. Inouye Solar Telescope.
WEBTOON Entertainment Announces Participation in Upcoming Investor Conferences
WEBTOON Entertainment will participate in two upcoming investor conferences in August and September 2026.Quiver AI SummaryWEBTOON Entertainment Inc. has announced its participation in two upcoming investor conferences: the Deutsche Bank 2026 Technology Conference on August 26 in Dana Point, CA, and the Goldman Sachs Communacopia + Technology Conference on September 10 in San Francisco, where it will present at 4:25 PM PT. The Goldman Sachs presen
Ari Emanuel's Mari Acquires Theater Owner ATG Entertainment For $6B
The deal size has been estimated at $6 billion, as the live events company establishes a bigger foothold in the theater industry.
Injuries can take a mental toll on athletes
How do athletes handle being on the injured list? Dr. Josefine Combs can help athletes cope and come back mentally stronger.
Injuries can take a mental toll on athletes
How do athletes handle being on the injured list? Dr. Josefine Combs can help athletes cope and come back mentally stronger.
WEBTOON Entertainment Inc. to Participate in Upcoming Investor Conferences
LOS ANGELES, Aug. 11, 2026 (GLOBE NEWSWIRE) -- WEBTOON Entertainment Inc. (Nasdaq: WBTN) (“WEBTOON Entertainment” or “the Company”), a leading global entertainment company and home to some of the world’s largest storytelling platforms, today announced it will participate in the following upcoming investor conferences: Deutsche Bank 2026 Technology ConferenceAugust 26, 2026Location: Dana Point, CA Goldman Sachs Communacopia + Technology ConferenceSeptember 10, 2026Presentation Time: 4:25 PM PTLoc
'A Must-Have Day 1 Purchase': Remedy Bets Big on Control Resonant, as Alan Wake 2 Passes 3 Million Sold
Alan Wake and Control developer Remedy is betting big on Control Resonant, as Alan Wake 2 finally passes 3 million copies sold.
Political campaigns hock merchandise at Colorado’s goths, gays and gun owners
Mid-term candidates get creative in campaign apparel.
Health Dept. survey asks where residents look for health information
JACKSON, Wyo. — The Teton County Health Department (TCHD) is interested in learning where the community finds health information. An online survey from TCHD asks questions about where health information is received and how residents prefer to learn about Health Department news. The survey, available in both English and Spanish, takes about 5 minutes and […]
Neil Leibman exits Texas Rangers chairman role to pursue new business opportunities
Neil Leibman has stepped down from his role with the Texas Rangers as chairman of the company that oversees local television broadcasts of games, and the MLB team’s sports and entertainment group.
Harger: A Kent business lost $90,000 to copper wire theft. The accused got $113.40 at a recycler. The receipt was in his truck.
$113.40. That's what the copper was worth at the recycler. The business it came from has lost more than $90,000. Merry Christmas.
The science behind tomatoes and better health
Tomatoes contain lycopene and other nutrients linked to heart and prostate health. Learn the science and how to add tomatoes to your diet.
The science behind tomatoes and better health
Tomatoes contain lycopene and other nutrients linked to heart and prostate health. Learn the science and how to add tomatoes to your diet.
Minnesota Cannabis Businesses Grapple With Growing Pains
Minnesota's hyper-regulated cannabis industry is starting to bear fruit—er, flower. But uncertainties remain about whether operators have sufficient breathing room to build viable businesses.
Nearly 100 never-before-seen Nintendo cartridges found in Wisconsin game shop
A Wisconsin game shop discovered almost 100 copies of a never-before-seen version of Super Mario Bros. and Duck Hunt cartridges in storage.
Record Backlog Powers NRC Health’s (NRC) Upward Potential
Long Cast Advisers, an independent registered investment adviser, released its Q2 2026 investor letter. A copy can be downloaded here. The firm reported strong earnings in the second quarter, with results improving 20%, bringing year-to-date returns to +19%. While performance trailed the Russell 2000 and iShares US MicroCap ETF, it remained well ahead of the […]
Scientists Release Biggest 2D Map of the Universe
Key Takeaways The DESI Legacy Imaging Surveys combined more than 263,000 telescope exposures to make the largest 2D map of the universe in visible and near-infrared light. Astronomers can pair the Legacy Surveys map with their own observations to explore our universe and search for rare phenomena. The 2D map serves as the foundation for the Dark Energy Spectroscopic Instrument survey to measure the universe in 3D and investigate dark energy. Hold on to your telescopes: the DESI Legacy Imaging Surveys team has released the largest-ever 2D color map of the universe. The 5.6-trillion-pixel map contains nearly 4 billion celestial objects, primarily stars and galaxies. The data is available for all to use and publicly viewable through the Legacy Survey Sky Viewer. Astronomers and citizen scientists can explore the map or combine it with their own observations to better understand our universe. Researchers can search for rare phenomena like gravitational lenses, observe fleeting events like supernovae, and investigate two of physics’ biggest mysteries: dark matter, the invisible substance that accounts for most of the mass in our universe, and dark energy, the force driving our universe’s accelerating expansion. The new map builds on earlier versions from the DESI Legacy Imaging Surveys that have already proved invaluable. To date, more than 1,800 science papers that reference the Legacy Surveys data have been published. “It’s part of the fabric of astronomy research now,” said David Schlegel, a co-lead of the Legacy Surveys and scientist at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab). “When you’re working with astronomical objects today, you often start by pulling up the Legacy Imaging Viewer to see what you’re looking at.” Covering roughly 75% of the sky in visible and near-infrared light, the updated map provides a deep view of the extragalactic universe not blocked by the dust and stars of our own Milky Way. Researchers expect it will remain the most comprehensive 2D map of our universe for years to come. More than 160 scientists contributed to data collection for the project, and a team of 20 produced the final dataset released today. It was built by combining 263,407 telescope exposures from three ground-based sky surveys: the Dark Energy Camera Legacy Survey (DECaLS) at NSF Cerro Tololo Inter-American Observatory, the Mayall z-band Legacy Survey (MzLS) at NSF Kitt Peak National Observatory, and the Beijing-Arizona Sky Survey (BASS) at the University of Arizona’s Steward Observatory. That was supplemented by years of data from NASA’s Wide-field Infrared Survey Explorer (WISE) satellite mission and additional public data. “For our team, these data are fundamental to our investigation of the expansion history of the universe and the formation of our galaxy,” said Arjun Dey, co-lead of the Legacy Surveys and an astronomer at NSF NOIRLab. “But the skies belong to everyone, and this survey gives everyone the chance to explore the sky and marvel at its wonders.” Here be galaxies The DESI Legacy Imaging Surveys were originally conducted to prepare for the Dark Energy Spectroscopic Instrument (DESI) survey. The Legacy Surveys’ 2D map is essentially a deep photograph of the sky; it records where galaxies and stars appear and how bright they appear. This crucial step enables DESI to select objects and measure their light in different wavelengths to determine their distances, building the largest high-resolution 3D map ever made. Scientists study the way galaxies have clustered at different ages of the universe to track dark energy over time. In April 2026, DESI completed its original five-year survey ahead of schedule and with vastly more objects than expected. The early results have shown surprising hints that dark energy’s impact may be weakening over time — a paradigm shift that could potentially shape the predicted fate of our universe. DESI expects to publish improved results using their first five years of data in 2027 and is continuing observations into 2028. DESI was so efficient at observing galaxies, the Legacy Surveys map needed to expand. Early on, “it became clear we might run out of galaxies to look at and run out of sky, and we better start doing something about that,” said Schlegel, who also works on DESI. The new Legacy Surveys map has been used to select DESI targets since June 2026 and will guide the telescope’s operations over the coming years. Computing the cosmos Merging hundreds of thousands of images taken on 2,285 nights, each with unique atmospheric and telescope conditions, was a massive computational effort. It took about a year to develop the computer code and eight weeks to process all the images at the Perlmutter supercomputer at the National Energy Research Scientific Computing Center (NERSC) at Berkeley Lab. Beyond supporting DESI, the Legacy Surveys will be a foundational reference for the next generation of telescopes. As new observatories like the NSF-DOE Vera C. Rubin Observatory (jointly funded by NSF and DOE’s Office of Science) and NASA’s Nancy Grace Roman Space Telescope come online, researchers can compare their observations with one of the deepest and most comprehensive views of the sky ever assembled. The Legacy Surveys data will also help scientists train artificial intelligence tools to analyze petabytes of astronomical data and accelerate new discoveries. It will be among the datasets used in an astrophysics pilot project within the American Science Cloud, part of the DOE’s Genesis Mission. The DESI Legacy Imaging Surveys are supported by the U.S. Department of Energy’s Office of High Energy Physics; the National Energy Research Scientific Computing Center, a DOE Office of Science user facility; the U.S. National Science Foundation, Division of Astronomical Sciences; and the partner institutions. DESI is supported by the DOE Office of Science and NERSC. Additional support for DESI is provided by the NSF; the Science and Technology Facilities Council of the United Kingdom; the Gordon and Betty Moore Foundation; the Heising-Simons Foundation; the French Alternative Energies and Atomic Energy Commission (CEA); the Secretariat of Science, Humanities, Technology and Innovation (SECIHTI) of Mexico; the Ministry of Science and Innovation of Spain; and by the DESI member institutions. ### Lawrence Berkeley National Laboratory (Berkeley Lab) is committed to groundbreaking research focused on discovery science and solutions for abundant and reliable energy supplies. The lab’s expertise spans materials, chemistry, physics, biology, earth and environmental science, mathematics, and computing. Researchers from around the world rely on the lab’s world-class scientific facilities for their own pioneering research. Founded in 1931 on the belief that the biggest problems are best addressed by teams, Berkeley Lab and its scientists have been recognized with 17 Nobel Prizes. Berkeley Lab is a multiprogram national laboratory managed by the University of California for the U.S. Department of Energy’s Office of Science. DOE’s Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit energy.gov/science.
NFIB backs small-business 'champion’ María Elvira Salazar for re-election in CD 27
‘South Florida runs on small business.’
Dodge’s new Charger Super Bee ups the inline-six’s output to 600bhp
Iconic name comes back alongside new turbos, uprated brakes, extra aero and insect graphics
Lion Nebula Roars to Life With NASA’s Webb
Observing across the starry “plains” of space, NASA’s James Webb Space Telescope has taken new images of NGC 2392, nicknamed the Lion Nebula. NASA’s Hubble
As Sky-High Health Care Costs Top Voter Concerns, Families USA’s Stop the Bleed: Cut Costs, Not Care Campaign Gains Nationwide Momentum
SEIU, MomsRising, Community Change, Popular Democracy, Main Street Alliance, Small Business Majority, and Others Join Effort to Rein in High Health Care Costs WASHINGTON, D.C. — Families USA announced today that its Stop the Bleed: Cut Costs, Not Care campaign is now officially active in all 50 states. Launched in January, Stop the Bleed is […]
WHO says Ebola outbreak in Congo started months earlier
The World Health Organization says the Ebola outbreak in eastern Congo started in February, months before it was officially declared on May 15.
Delaware Implements Collaborative Communication Platform for Heart Health
Learn how Delaware leveraged online tools to improve collaboration between partners working to reduce heart disease in the state.
Technosylva Fire Science Experts to Provide Bi-Weekly Wildfire Situational Awareness Briefings to Customers
/PRNewswire/ -- As extreme weather conditions continue to escalate, Technosylva, the global leader in wildfire and extreme weather risk intelligence, is...
Scientists Release Biggest 2D Map of the Universe - The new DESI Legacy Imaging Surveys map serves as the foundation for the largest-ever 3D map of the Universe, used to investigate dark energy
The newest DESI Legacy Imaging Surveys map, 13 years in the making, covers three-quarters of the sky and catalogs nearly four billion objects. This treasure trove is available to all and contains stars, galaxies, supernovae, gravitational lenses, and much more. Two NSF NOIRLab facilities contributed data to the map: the U.S. National Science Foundation (NSF) Mayall telescope and the NSF Blanco telescope, equipped with the U.S. Department of Energy-fabricated DECam.
High Volume Robotic-Assisted Bronchoscopies Offer Patients Exceptional Expertise
Pennsylvania pulmonology team surpasses 1,300 procedures
New TV shows to watch this week: Tune in to 'The Shards' on FX, stream 'Sterling Point' on Prime Video and revisit 'Sense8' on Netflix
Teen drama fans will fall for "Sterling Point" and "My Life with the Walter Boys." But don't overlook Taylor Sheridan, "Ted Lasso" or a gripping Netflix series.
The sun will vanish over Europe in a rare total solar eclipse: Watch live
A total solar eclipse will plunge parts of Europe into darkness on August 12, 2026, with Spain offering some of the best views. ESA will livestream the spectacle from the Javalambre Observatory, combining telescope feeds, drone footage, and expert commentary. At 20:31 CEST, the observatory will experience 1 minute and 21 seconds of totality, revealing the Sun’s normally hidden outer atmosphere.
450,000 NYers just lost their health insurance: How one Syracuse caregiver is coping
Tyler Lyons' no-cost health insurance was a casualty of cuts to the Affordable Care Act.
Couple turns passion for helicopters into a national business that’s anchored in Detroit
Cassandra and Sergio Troiani turned a hobby flying helicopters into a national aviation experience company — and they just anchored it in Detroit.
Starz Entertainment Corp. Stock 12‑Month Price Target Raised to $33.33, Implies 27% Upside
Explore more price target data and ratings for Starz Entertainment Corp. on the Forecasts tab, and track all previous and future analyst recommendations for Starz Entertainment Corp. in the dedicated News Flow.Select reference data provided by FactSet. Copyright © 2026 FactSet Research Systems Inc…
Bronchiectasis: How To Manage Your Mental Health and Stay Connected
If daily symptoms and flares take their toll on your mental health, you’re not alone. A pulmonologist shares how to cope and manage.
Clemson Legend Cade Klubnik is Hearing Some Loud NFL Concerns
Former Clemson Tigers quarterback Cade Klubnik is under the microscope with the New York Jets.
Incoming Inglewood Transit Connector project to displace more than a dozen businesses
The shopping center will be torn down for the Inglewood Transit Connector, a parking structure and bus loop that aim to make transit in the area more efficient.
Sony Will Remain Mum On PlayStation Disc Making Process
While PlayStation seems committed to ending their physical copies, I wouldn’t hold my breath for a massive homebrew scene to fill the void in the immediate future
Copying Taylor Swift's everyday habits could make you happier, according to science
Science suggests the everyday gestures Swift practices can boost happiness for everyone, not just celebrities
Rare Nintendo cartridges found in storage could be worth millions
A box of Nintendo games could be worth millions. It had nearly 100 copies of a previously unknown version of Super Mario Bros. and Duck Hunt.
Stateline Sports Reporters Podcast: ETSU, Tennessee, Virginia Tech Football Preview
WCYB NBC 5 Bristol and WEMT Fox 39 Greeneville offer local and national news reporting, sports, and weather forecasts to viewers in the Tennessee, Virginia Tri-Cities area including Bristol, Kingsport and Johnson City.
UW-Eau Claire student’s self-advocacy brings accessible microscope to science lab
Nursing major with low vision pushed for change — and her whole class is benefiting
Lubbock business news includes restaurant closure, hotel sale
Business Reporter Alana Edgin reviews recent Lubbock area businesses news and hints at upcoming articles in the Around the Hub column.
Driven Just 9K Miles, This 1977 BMW E21 Is About As Frozen In Time As It Gets
For more than 40 years, this E21-generation 3-Series remained under the stewardship of its original owner
49ers’ Kyle Shanahan speaks on his health, players’ injuries, Tesla autopilot
Kyle Shanahan is better but coping with headaches and fatigue from his July 14 car crash that may have involved a malfunction in Tesla’s autopilot program.
YouTube Mistakes Popular Science Channel For AI Slop
The science and technology explainers warned audiences in the past about the entropy AI will unleash upon the web and after being forced to remove a video on microscopic superpredators, they're living through it
Taylor Swift removes multiple songs from Trump social media posts
An official Donald Trump campaign account used multiple Taylor Swift songs in TikTok posts supporting the president —until copyright claims removed the singer’s music from the account.
Google’s Pixel Watch 5 takes notes from the Fitbit Air in latest leak
Google's Pixel Watch 5 is set to copy a key element from the Fitbit Air in the latest leak around the upcoming smartwatch.
Washington Nationals Expected to Promote 2026 First Round Pick
First round pick and former Texas A&M infielder Chris Hacopian is expected to be promoted this weekend
This tiny gold crystal could bring quantum technology out of the deep freeze
Scientists have created the first quantum material that can sort and transport different quantum states of light at room temperature, potentially removing the need for bulky, ultra-cold refrigeration systems. Built from a gold film carved with hundreds of microscopic structures, the ultrathin “metacrystal” acts like a filter that directs different kinds of quantum light along separate paths while preserving the information they carry.
Colorado Politics Calendar Aug. 10-16
CoPo’s weekly political calendar will help you find political and public-policy events throughout Colorado. It includes candidate and issue campaign events, public policy meetings, court hearings, state and local party conventions, assemblies, debates, rallies, parades, speaking engagements, traveling dignitary appearances, water meetings, book signings, county commission hearings, city council meetings and more. As a subscriber, […]
Youth sports data collection lacks cybersecurity safeguards
Parents are increasingly required to submit copies of child's birth certificate for youth sports participation. This can have life-long repercussions.
US Senate confirms Mark Cruz to lead Indian Health Service
Senior Health and Human Services advisor Mark Cruz will now lead the U.S. agency that provides healthcare to some 2.8 million Native Americans.
Practice Management Course is now Business of Sleep Medicine
The AASM Practice Management Course has been reintroduced as the Business of Sleep Medicine to reflect a broader scope.
Second-year health careers opportunity program at SAU prepares next generation of health professionals | News
Southern Arkansas University hosted its second year of the Health Careers Opportunity Program (HCOP) Academy, an initiative funded by the Health Resources and Services Administration and coordinated…
Business Restructuring Review Vol. 25 No. 4 July-August 2026
In This Issue New York Bankruptcy Court: Premature Allegations of Creditor Mistreatment Insufficient to Deny Chapter 15 Recognition of Foreign Restructuring Proceeding In In re ARD Finance, S.A., No. 25-12794 (MG), 2026 WL 817458 (Bankr. S.D.N.Y. Mar. 25, 2026), the U.S. Bankruptcy Court for the Southern District of New York was presented with a petition seeking chapter 15 recognition of Luxembourg's recently enacted bankruptcy law governing judicial reorganization proceedings. The court granted the petition, turning aside challenges to recognition voiced by a creditor group arguing that recognition should be denied based upon allegations of unfairness to creditors in the Luxembourg proceeding that would make recognition manifestly contrary to U.S. public policy. According to the bankruptcy court, recognition was warranted because: (i) the rules and procedures governing the proceeding under Luxembourg law were fundamentally fair; (ii) the petition otherwise satisfied chapter 15's recognition requirements; and (iii) the creditor group's allegations were premature, given the fact that the Luxembourg court presiding over the debtor's restructuring proceeding had not confirmed a restructuring plan, and all creditors had the right to participate fully and voice their objections in the proceeding (including the right to appeal an order approving a plan). [read more …] Florida Bankruptcy Court Examines Scope of Discovery in Chapter 15 Cases In In re Banco Master, S.A., No. 25-24568-SMG, 2026 WL 931729 (Bankr. S.D. Fla. Apr. 6, 2026), the U.S. Bankruptcy Court for the Southern District of Florida granted in part and denied in part post-recognition motions filed by an insider of a foreign debtor seeking to bar or limit discovery sought by the debtor's foreign representative concerning allegedly voidable transfers involving the debtors' U.S. real property. According to the court: (i) although chapter 15 includes its own discovery provisions among the relief that may be granted to a foreign representative, the expansive discovery available in cases under other chapters of the Bankruptcy Code is also available in chapter 15 cases; (ii) the discovery sought by the foreign representative was permissible; (iii) discovery regarding matters that were the subject of a pending adversary proceeding had to be undertaken under the more restrictive rules applicable to such proceedings; and (iv) a discovery request would be barred to the extent that it sought production of documents or testimony from a subpoenaed entity that exceeded the geographic limitations specified in such rules. [read more …] Delaware District Court Affirms Chapter 15 Recognition Order Enforcing Nonconsensual Third-Party Releases In U.S. Int'l Dev. Fin. Corp. v. Credito Real S.A.B. de C.V. SOFOM, E.N.R. (In re Credito Real S.A.B. de C.V. SOFOM, E.N.R.), 677 B.R. 192 (D. Del. 2026), appeal filed, No. 26-2356 (3d Cir. June 5, 2026), the U.S. District Court for the District of Delaware affirmed a bankruptcy court order granting chapter 15 recognition to a Mexican "concurso mercantile" proceeding and enforcing nonconsensual third-party releases approved by the Mexican court. Agreeing with the bankruptcy court that the releases were not manifestly contrary to U.S. public policy, the district court concluded: "It is well settled that U.S. bankruptcy courts can give effect to foreign orders in recognized foreign proceedings pursuant to the authority granted in Chapter 15, even when those orders contain relief unavailable under U.S. law. [The appellant's] arguments misconstrue the Supreme Court's narrow holding in Purdue, applicable in Chapter 11 cases, as well as the statutory framework of Chapter 15 and its core policy objectives. Accordingly, I will affirm the Enforcement Order." The ruling has been appealed to the U.S. Court of Appeals for the Third Circuit. [read more …] Fifth Circuit: Bankruptcy Court, Not State Court, Had Jurisdiction to Allow or Disallow Administrative Expense Claim In Storey Minerals Ltd. v. EP Energy E&P Co., LP (Matter of EP Energy E&P Co., LP), 169 F.4th 609 (5th Cir. 2026), the U.S. Court of Appeals for the Fifth Circuit affirmed lower courts' rulings disallowing a creditor's administrative expense claim. It also rejected the creditor's argument that, because the claims were predicated on state law, a state court should adjudicate the merits of the state law causes of action before the bankruptcy court could allow or disallow the claim as an administrative expense. According to the Fifth Circuit, even though the causes of action were based on state law, the bankruptcy court had jurisdiction to determine whether the creditor's claims should be conferred with administrative expense priority in the debtors' chapter 11 case. [read more …] New York Bankruptcy Court: Dismissal of Involuntary Chapter 11 Case Filed Prior to Commencement of Foreign Restructuring Proceeding Unwarranted In In re Xinyuan Real Estate Co. Ltd., No. 25-10745 (PB), 2026 WL 592250 (Bankr. S.D.N.Y. Mar. 3. 2026), the U.S. Bankruptcy Court for the Southern District of New York considered the bona fides of an involuntary chapter 11 petition filed by certain holders of U.S. dollar-denominated notes against a holding company for a group of Chinese property development companies that filed a restructuring proceeding in the Cayman Islands after the noteholders filed the involuntary chapter 11 petition. The court denied the debtor's motion to dismiss the chapter 11 case. Given the timing of the filing of the Cayman Islands restructuring proceeding, the absence of any progress in the proceeding for seven months, the debtor's need to restructure notes governed by U.S. law, and the debtor's lack of any meaningful contacts to the Cayman Islands, dismissal of the chapter 11 case was unwarranted under the applicable provision of the Bankruptcy Code, international comity, or the doctrine of forum non conveniens. [read more …] Bankruptcy Court Evaluates Trustee's Authority to Sell Avoidance Actions and Right of Target Defendants to Object In In re Law Enf't Officers Sec. Union, No. 24-70277-JAD, 2026 WL 560452 (Bankr. W.D. Pa. Feb. 27, 2026), a chapter 7 trustee sought court approval to sell certain avoidance actions to a creditor of the debtor's estate. Potential targets of the subject avoidance actions objected, arguing that such claims were nontransferable powers of the trustee rather than saleable estate property and urging the court to approve their competing settlement with the trustee. The U.S. Bankruptcy Court for the Western District of Pennsylvania disagreed with the potential defendants, holding that they lacked standing to object to the proposed sale, that avoidance actions are indeed estate property, and that the sale—rather than the settlement—best served the estate's interests. [read more …] U.S. Supreme Court Bankruptcy Roundup in Brief In Keathley v. Buddy Ayers Construction Inc., No. 25-6, 2026 WL 1686028 (U.S. June 11, 2026), the U.S. Supreme Court overturned a Fifth Circuit decision judicially estopping a chapter 13 debtor from asserting a personal injury claim against a construction company because the debtor failed to disclose the claim during his bankruptcy case. In so ruling, the Court held that "[t]he Fifth Circuit erred by artificially narrowing its inquiry to whether the debtor had knowledge of the underlying facts or a potential motive to conceal the claim." It represents the first time that the Court has applied judicial estoppel in the bankruptcy context, although it has suggested in other contexts that it may be inappropriate where an inconsistent legal position resulted from "inadvertence or mistake." Also in June, the Court denied petitions for certiorari in a few notable bankruptcy cases. [read more …] Newsworthy Heather Lennox (Cleveland/New York) (Star Individual), Bruce Bennett (Los Angeles) (Senior Statesperson), Kevyn D. Orr (Washington) (Eminent Practitioner), Gregory M. Gordon (Dallas) (Band 1), Carl E. Black (Cleveland), Corinne Ball (New York) (Senior Statesperson), Brad B. Erens (Chicago), Jeffrey B. Ellman (Atlanta), T. Daniel Reynolds (Cleveland), and Dan T. Moss (Washington/New York) were recognized as leading lawyers in the practice area Bankruptcy/Restructuring in the 2026 edition of Chambers USA: The World's Leading Lawyers for Business. The 2026 edition of Lawdragon 500 Leading Bankruptcy and Restructuring Lawyers ranked the following lawyers: Corinne Ball (New York) (Hall of Fame), Bruce Bennett (Los Angeles), Carl E. Black (Cleveland), Jeffrey B. Ellman (Atlanta), Brad B. Erens (Chicago), Gregory M. Gordon (Dallas), Heather Lennox (Cleveland/New York), Joshua M. Mester (Los Angeles), and Kevyn D. Orr (Washington). Fabienne Beuzit (Paris) and Jasper Berkenbosch (Amsterdam) were among the "Leading Individuals" ranked in the 2026 edition of The Legal 500 EMEA guide in the field of Restructuring and Insolvency or Insolvency. Rodolphe Carrière (Paris) was named a "Next Generation Partner" in the practice area Insolvency. Sid Pepels (Amsterdam) was selected by Global Restructuring Review's 40 under 40 2026. He was identified as a Rising Star within the global cross-border restructuring community. Global Restructuring Review is a leading digital subscription service, news outlet, and information platform dedicated exclusively to cross-border insolvency and corporate restructuring law. Fabienne Beuzit (Paris), Rodolphe Carrière (Paris), and Isabelle Maury (Paris) were recognized in the 2027 edition of The Best Lawyers in France™ in the practice area Insolvency and Reorganization Law. An article written by Corinne Ball (New York) titled "Comity and Fairness are Critical to Granting Additional Assistance under Chapter 15: A Canadian Reverse Vesting Order and Related Releases in Proceedings Involving Canadian and U.S.-Affiliated Companies Are Approved" was published in the June 24, 2026, edition of the New York Law Journal. An article written by Caitlin K. Cahow (Detroit) titled "New York Bankruptcy Court Weighs In on Adequate Assurance of Future Performance under Assigned Leases and Chapter 11 Plan Exculpation Provisions" was published on June 8, 2026, in Lexis Practical Guidance. An article written by Trisha L. Mowbray (Real Estate; Chicago) and Ryan Sims (Washington) titled "Chapter 11 Plan that Abridged Non-Debtor Lessee's Rights to Remain in Possession After Rejection Unconfirmable as Having Been Proposed in Bad Faith" was published on June 16, 2026, in the Harvard Law School Bankruptcy Roundtable. An article written by Dan T. Moss (Washington/New York), Corinne Ball (New York), Isel M. Perez (Miami), and David S. Torborg (Washington) titled "Texas Bankruptcy Court Adopts Barnet Rule Requiring Foreign Debtor to Have U.S. Assets to Be Eligible for Chapter 15 Relief" was published on June 10, 2026, in Lexis Practical Guidance. An article written by Daniel J. Merrett (Atlanta) and Nathaniel Parr (Atlanta) titled "Southern District of Texas Clarifies Post-Purdue Course for Consensual Third-Party Releases and Gatekeeping Provisions" was published on June 11, 2026, in Lexis Practical Guidance. An article written by Corinne Ball (New York) titled "LMEs, Sophisticated Investors and Equitable Mootness: The Fifth and Third Circuits Warn Against Testing the Limits of Chapter 11" was published in the June 2026 issue of the American Bankruptcy Institute Journal. Nicholas J. Morin (New York) was quoted in an article titled "Serta Ruling Offers Damages Road Map in Lender-on-Lender Disputes," published by Bloomberg Law on July 7, 2026. The article discussed U.S. Bankruptcy Judge Christopher Lopez's July 7, 2026, ruling that participating lenders in Serta Simmons Bedding's 2020 non-pro rata uptier exchange breached the credit agreement's ratable-sharing provision, and awarding excluded lenders more than $261 million in damages. The opinion resolves six years of litigation related to Serta's 2020 transaction, where it raised $200 million in new financing and exchanged $1.2 billion of term loans for $875 million in superpriority debt. Judge Lopez found that the debt-for-debt exchange constituted a "payment" under the credit agreement, requiring proportional sharing among lenders, and dismissed various defenses raised by the participating lenders. The case is Serta Simmons Bedding LLC v. AG Centre Street Partnership (In re Serta Simmons Bedding LLC), 2026 WL 1968535 (Bankr. S.D. Tex. Jul. 7, 2026). The New York Law Journal has recognized Andrew M. Butler (New York) as a 2026 "Rising Star" in Restructuring/Bankruptcy as part of the New York Legal Awards. The Rising Star category recognizes New York's most promising lawyers age 40 and under who have distinguished themselves through exceptional legal work, leadership, and contributions to the profession. Lawyer Spotlight: Daniel J. Merrett Dan Merrett, a partner in the Atlanta Office, has spent nearly 20 years representing all manner of stakeholders in complex corporate restructurings and chapter 11 reorganizations. His practice extends to related transactions and disputes involving acquisitions; divestitures; credit facilities; securities; environmental obligations; and vendor, employee, and governance matters. Dan has substantial experience managing mass tort liabilities, including the restructurings and related chapter 11 cases of affiliates of Georgia Pacific and Johnson & Johnson, implemented to resolve asbestos and talc liabilities. He also represents key parties in energy and infrastructure matters, including facility owners, EPC contractors, and joint-venture parties. Dan was a key player in the restructuring teams in the historic bankruptcies of the City of Detroit and Chrysler. His other significant representations in chapter 11 cases include AFA Foods, Alpha Natural Resources, Dana Corporation, M&G Chemicals, McDermott International, Monster/CareerBuilder, Transtar Industries, and Westinghouse. He is licensed in both the United States and England & Wales and recognized in restructuring by Chambers USA and Best Lawyers.
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Viewpoint: Europe needs a new scientific contract
The White House's new science strategy should be required reading in the Berlaymont and every European capital.Not because Europe should copy it. Parts of it should concern Europeans deeply. But because it asks the question Europe has so far avoided while steadily losing ground in the global race for technological leadership.Europe already possesses many of the world's finest universities, scientists and research-intensive companies. It produces world-leading research in fields ranging from quantum technologies and biotechnology to climate science. Yet time and again Europe generates the scientific breakthroughs while others build the companies, industries and strategic advantages around them, particularly in digital technologies. Increasingly, we find ourselves regulating technologies whose underlying capabilities were developed elsewhere.This is not primarily a scientific failure. It is an institutional one.The settlement that shaped modern science policy emerged after the Second World War. In Science, the Endless Frontier, Vannevar Bush argued that governments should invest in fundamental research while protecting scientists from political direction. Public investment was justified precisely because no government, university or company could predict where the next transformative discovery would emerge.That scientific contract served liberal democracies extraordinarily well. It underpinned decades of advances in medicine, computing, energy and communications, but the world for which it was designed no longer exists.Artificial intelligence is transforming not only technology but the production of knowledge itself. Advanced chips, computing power, data and scientific instruments have become strategic assets. Scientific knowledge now diffuses globally almost instantly. Competitive advantage increasingly lies not in making discoveries first, but in possessing the infrastructure, capital, engineering capability and institutions required to translate those ideas into products, industries and strategic advantage.The old boundaries between science, industrial policy, national security and geopolitics have largely disappeared. Dual-use technologies now underpin both economic power and military deterrence.The US has recognised this shift. In July, the White House published Science: A New Golden Age, a comprehensive attempt to rethink the relationship between science and national power. The report builds on Bush's legacy, but departs from his framework in important ways. Science is no longer treated simply as the source of future discoveries. It is presented as the foundation of economic resilience, technological leadership and national security. AI, advanced infrastructure and the capacity to build become as important as discovery itself.Yet the report also reveals a striking paradox. The same administration calling for “a new golden age” of US science has simultaneously proposed deep cuts to the federal research enterprise while expanding political influence over the allocation of public research funding. Europe should therefore distinguish between the report's diagnosis and its prescription. The diagnosis, that science has become a strategic asset, is compelling. But the prescription is self-defeating. Long-term technological leadership depends on strong universities, academic freedom and the institutional autonomy that makes scientific discovery possible. This distinction matters. Bush's achievement was never simply to make science serve national strength. It was to establish a division of labour in which governments invested in research without attempting to direct discovery itself. Scientific breakthroughs emerge precisely because researchers retain the freedom to pursue questions whose value cannot yet be demonstrated and whose conclusions cannot be anticipated.Neither China, nor the USAs science becomes more strategically important, the temptation to politicise it inevitably grows. But scientific freedom is not an obstacle to technological leadership, it is an essential precondition.China represents the opposite model. For decades it has integrated science, manufacturing, infrastructure and industrial policy into a single national strategy. Its ability to mobilise resources around critical technologies is formidable. But it does so within an authoritarian system where scientific priorities are increasingly inseparable from political power.Europe should imitate neither model. It should learn from the strategic ambition of the US without importing its growing politicisation of science. And it should learn from China's capacity to build without adopting its concentration of power.Instead, Europe needs a scientific contract of its own. Bush's scientific contract protected the freedom to discover because the defining challenge of the 20th century was producing new knowledge. Europe's next scientific contract must preserve that freedom while ensuring that scientific discoveries can be converted into technological, industrial and strategic capability. Because in a transactional world, Europe's freedom to shape its own future depends on its capacity to build it.Related articlesThe US ‘golden age’ science strategy: what Europeans need to knowEuropean researchers sound the alarm that Trump rule changes will hit cooperationNIH turmoil risks reciprocal EU-US access to health research fundingThis does not mean subordinating free science to competitiveness or industrial policy. On the contrary. Scientific autonomy remains the first principle of Europe's next scientific contract. Governments should not direct scientific discovery. Their responsibility is to ensure that Europe's scientific, industrial, financial and regulatory institutions work together rather than in isolation.Meeting that responsibility requires far more than research funding. European researchers need access to world-class computing infrastructure, advanced laboratories, shared datasets and scientific facilities. Innovative companies need patient capital, testing environments and a genuine single market in which they can scale without facing 27 different regulatory regimes. Public procurement must evolve from purchasing existing technologies to creating markets for new ones. Regulators must become partners in experimentation rather than guardians of yesterday's rules.A connecting architectureEurope does not need to invent the Defense Advanced Research Projects Agency (Darpa) model from scratch. Britain's Aria, Germany's Sprind and Wellcome Leap already show that Europe can build institutions capable of taking high-risk, mission-oriented bets while preserving democratic accountability. The challenge now is not to create more isolated initiatives, but to connect them to Europe's broader scientific, industrial and financial system so that breakthrough discoveries can scale.Above all, Europe must stop treating research, innovation, industrial policy, finance and security as separate policy domains. The challenge is no longer to create excellent institutions in each of these fields, but to make them work as one European innovation system. Europe's strength will increasingly depend not on excellence within institutions, but on excellence across them.Europe's ambition should be neither to imitate the US nor to emulate China. It should demonstrate that scientific freedom, democratic legitimacy and technological capability are not competing objectives, but mutually reinforcing strengths. In an age of geopolitical rivalry, Europe's greatest advantage may ultimately be its ability to attract the world's best talent by combining scientific freedom, democratic openness and technological ambition.Bush's scientific contract helped define the 20th century because it protected the freedom to discover. Europe's challenge is not to abandon that achievement but to extend it. The defining task of Europe's next scientific contract is to preserve the freedom to discover while building Europe's capacity to translate scientific discovery into technological power.Kaare Nielsen is founder of Pomus, a Danish think tank on science and innovation.
Exclusive | Senate Panel Says It Has Obtained Copy of Fauci’s Covid-Era Phone
Republicans in Congress have ramped up scrutiny of the retired government doctor, and one panel could vote on holding him in contempt on Thursday.
Sanofi suspends chronic lung disease phase 2 study, tied to ‘strategic business reasons’
Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce Biotech has learned. The trial, which began only back in April, was a randomized, double-blind, placebo-controlled study to measure the reduction in mucus plug score following treatment with SAR445399 compared with placebo in adults aged 18 to 80 years with NCFB, a chronic lung disease. The trial was officially reported as halted on July 29, the day before Sanofi’s second-quarter earnings call. The decision to pause the trial was made “as part of a company-wide portfolio review for strategic business reasons,” and not due to safety concerns, a Sanofi spokesperson told Fierce. The move to pause the NCFB trial comes during a trying time for Sanofi following a year filled with a series of trial fails. In February, the French pharma ousted CEO Paul Hudson and appointed Merck KGaA leader Belén Garijo, M.D., Ph.D., to steer the ship. Since then, Garijo has been doing a deep dive on correcting the company’s strewn R&D and clinical strategies. On July 24, Sanofi scrapped amlitelimab for atopic dermatitis, despite its lore as being a potential $5 billion blockbuster. During its second-quarter report, the company abandoned two more assets, balinatunfib and itepekimab, following failed trial results in psoriasis and chronic obstructive pulmonary disease, respectively. SAR445399, only first revealed by Sanofi in 2023, is an anti-interleukin-1 receptor 3 monoclonal antibody developed to block the interleukin 1, 33, and 36 cytokine pathways. These pathways can be important in chronic immune-related dermatologic diseases, such as atopic dermatitis and hidradenitis suppurativa, as well as respiratory conditions, such as NCFB. Related Sanofi’s new CEO ‘looking deeply’ at late-stage pipeline as clinical clearout continues NCFB affects roughly half a million people in the U.S., with a global incidence of greater than one million cases. In August 2025, Insmed received FDA approval for Brinsupri, a DPP1 inhibitor targeting neutrophil activation, for treatment of NCFB in adults and kids ages 12 and older. The British biotech Infex Therapeutics showed promising NCFB phase 2a data using their monoclonal antibody, INFEX702, which acts by disabling Pseudomonas aeruginosa, a bacteria known to be a major pathogen of NCFB. Sanofi is currently running a separate phase 2 study testing SAR445399 as a potential treatment for the inflammatory skin condition hidradenitis suppurativa.
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