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New York area lawmakers rally behind longtime head of WTC Health Program
The program has grappled with staffing shortages over the past year amid the federal layoffs and buyouts.
The Steelers' T.J. Watt fell out of the top five of ESPN's edge rusher poll. Should he have?
NFL decision makers don’t see T.J. Watt as one of the NFL’s elite edge rushers anymore. That’s what an annual ESPN poll of NFL executives,...
Jared Huffman is one of few nonreligious members of Congress
California Rep. Jared Huffman is one of just four openly agnostic or religiously unaffiliated lawmakers and is by far the most outspoken. His new book warns of the perils of rising Christian nationalism.
Exclusive: Epstein survivors say his former assistant Lesley Groff lied to Congress about key details
Multiple Epstein victims told CNN they took issue with multiple aspects of Groff’s recent testimony to lawmakers.
GOP leaders tried to quell McConnell health questions. It’s not working
As online speculation swirls over Sen. Mitch McConnell’s hospitalization and scant public updates from his staff, the Kentucky Republican’s top allies spoke up this week, insisting he remains alert. But those assurances have done little to quash demands for proof of life, including from the state’s governor. The episode has reignited a debate over lawmakers’ […]
World Cup betting surge fuels renewed push to legalize sports wagering in Texas
With the Texas Legislature set to return in January for their regular session, sports betting advocates are hoping lawmakers prioritize the topic.
World Cup betting surge fuels renewed push to legalize sports wagering in Texas
With the Texas Legislature set to return in January for their regular session, sports betting advocates are hoping lawmakers prioritize the topic.
Western N.Y. GOP lawmakers point to bail reform amid rise in violence
Lawmakers and candidates are speaking out after a Fourth of July weekend in which 11 people were shot in six separate shootings in Buffalo.
Michigan Democratic lawmakers introduce legislation to curb campaign spending power of corporations
State Rep. Betsy Coffia, a Democrat from Traverse City, and state Sen. Sean McCann, a Kalamazoo Democrat, introduced legislation in their respective chambers last week to limit the powers of business corporations, nonprofit corporations and limited liability companies to participate in campaign spending.
How crime and the politics of crime rise and fall in California
Over two decades, political pressure forced California lawmakers to toughen criminal penalties. Now that crime is down, what's next?
District attorneys, lawmakers celebrate changes to mental health diversion law
The newly signed law expands courts’ ability to deny mental health diversion to defendants in criminal cases.
The 2028 redistricting wars have already begun
The Maryland legislature is set to convene a special session next month after Democratic lawmakers proposed a constitutional amendment on redistricting.
Mitch McConnell, still hospitalized, spoke with GOP colleagues by phone
As questions swirl around Mitch McConnell's health, the GOP senator has been making lengthy phone calls to other lawmakers, a congressional aide said.
Supreme Court justices Kagan and Barrett to testify on Capitol Hill
Supreme Court Justices Amy Coney Barrett and Elena Kagan are scheduled to testify before Congress next week as lawmakers consider the judiciary’s funding request. Barrett and Kagan are slated to appear before the House Subcommittee on Financial Services and General Government on Tuesday, July 14, according to the House committee schedule. They will also testify […]
Questions over McConnell's health continue three weeks after medical emergency
Questions continue to swirl around the health of Sen. Mitch McConnell, R-Ky., more than three weeks after he was sent to the hospital due to a medical emergency. NBC News' Sahil Kapur has the latest on what lawmakers and reporters are hearing about the senator's health.
UnitedHealth says most home-health diagnoses were supported in 2025
UnitedHealth on Tuesday said an audit by an external consulting firm showed nearly 97% of diagnoses identified within its HouseCalls home-health unit, which has faced scrutiny from lawmakers, were supported by a patient's medical record.
Lawmakers end multi-million-dollar hospital tax “loophole”
By Michelle Crouch Co-published with The Charlotte Ledger A little-noticed provision in the state budget that was approved last week aims to shut down a tax strategy used by at least one hospital system to exceed the state’s sales tax refund cap. The change would require nonprofit and public hospital systems to file a single […]
Atlanta lawmakers ask Fulton County to invest $200 million in new South Fulton hospital, expanded healthcare
Fulton County commissioners are considering $200 million for a new hospital and expanded health care services in south and west Atlanta communities.
VFW defends First Amendment rights amid blowback over political cartoon
Lawmakers and veterans groups are divided on how to pay for a major veterans benefits reform bill.
An Urgent Threat to the Foundation of Federal Science Funding
New proposed regulations on the use of federal funding could cripple American science by replacing merit-based peer review of research projects with the whims of political appointees and ending support for the publication of research results. An entomologist and former federal government leader urges anyone who supports science to contact policymakers to oppose the proposed rules.
Rising healthcare costs are straining Texas businesses as the Legislature seeks solutions
Lawmakers and experts pin the blame for rising insurance costs on health companies consolidating and creating less competition.
Rising healthcare costs are straining Texas businesses as the Legislature seeks solutions
Lawmakers and experts pin the blame for rising insurance costs on health companies consolidating and creating less competition.
NYC axes new rule on roll-down gates for businesses – after retailers already spent thousands
City lawmakers rolled back an obscure, decades-old law about storefront roll-down gates ahead of a looming enforcement deadline – but not before some retailers shelled out thousands of dollars in...
Speaker Johnson says House will pass Trump’s voter ID bill through arduous process after GOP revolt
House Speaker Mike Johnson said he plans to move quickly to advance President Donald Trump’s signature voter ID legislation through the arduous budget reconciliation process once the House returns to Washington, downplaying the heightened tensions within the GOP after he sent lawmakers home early for the holidays after a few Republicans brought the floor to a halt.
It’s not clear how California’s education power shift will impact schools this year
After California lawmakers and the governor changed state law so the Department of Education is overseen by the governor instead of the state superintendent, it’s unclear how the move will impact the upcoming school year. "What we hope to see is a streamlining of the administration of public education in California," Assembly Education Chairwoman Assemblymember Darshana Patel, D-San Diego, said in an interview on California Politics 360.Patel helped carry the change through legislation at the state Capitol.
Top California public schools chief says he was left out of power shift decision
California’s top public schools official says he was left out of the negotiations and decision-making when the governor and state lawmakers approved a major education overhaul and stripped the Department of Education from his office.
California Politics 360 full episode | Major leadership shift for CA Education Dept.
As lawmakers and the governor passed the state’s spending plan for the year, they also approved a major change in who oversees the California Department of Education.
Prediction market betting would be authorized in NC’s new budget. What it means for sports betting
Tucked into the state budget is a proposal that could have massive implications for how prediction markets operate in North Carolina. Some lawmakers say it’ll create a new revenue stream. Others worry it’ll cost the state millions.
Data center controversies in the spotlight during Missouri primaries
Missouri residents and lawmakers are pushing for more transparency as data center projects expand across the state.
$28.5M modernization project planned at San Juan High School
Demolition and construction are taking place this summer at San Juan High School as part of a science wing and campus-wide modernization project, San Juan Unified School District officials say...
‘Check Your Political Identities at the Door’: Lawmakers Come to UVA Darden to Practice Leadership
A select group of state legislators will gather at UVA Darden for a nonpartisan leadership program focused on productive disagreement, values-based decision-making and leading across political differences.
NATO tensions push Europe to chart a path past Washington
Ahead of a major NATO summit in Ankara, Turkey next week, strain on the alliance is pushing European lawmakers toward a new posture—one that is less reliant on Washington.
Why you should wash new clothes before wearing; signs that you are aging well; effective leadership in health care; plus other stories with Vanderbilt Health sources
Jami Miller, MD, Professor of Clinical Dermatology, and David Gaston, MD, PhD, Assistant Professor of Pathology, Microbiology and Immunology, are quoted in a Southern Living piece about the importance of washing new clothes before wearing them. Dyes, chemicals, mold and bacteria are all potential troublemakers lurking around your new duds. Parul Goyal, MBBS, Associate Professor of Clinical Medicine, was quoted in a Huff Post story outlining signs that you are aging well. Tae Kon Kim, MD, PhD, Assistant Professor of Medicine, was interviewed by Healio for a story headlined, “Effective leadership in health care ‘starts with listening.’” AAMC News reporter Patrick Boyle interviewed Wes Ely, MD, Professor of Medicine and Critical Care, for a story about ICU delirium. PharmaVoice reporter Kelly Bilodeau interviewed Romney Humphries, PhD, Vice Chair and Executive Medical Director, Clinical Services, for a story about the CDC’s new data that shows an alarming increase in the prevalence of a gene that can make “nightmare bacteria” significantly harder to treat. American Community Media interviewed William Schaffner, MD, Professor of Preventive Medicine, for a piece about Ebola that was reused by several media outlets around the U.S., including The Mississippi Link. Stacie Dusetzina, PhD, Professor of Health Policy, was quoted by The Independent in a story about how Medicare will soon cover weight-loss drugs. Courtney Schadt, MD, Associate Professor of Dermatology, was interviewed by Tennessean reporter Beth Warren, about tanning safety and tanning fads circulating social media. WKRN News 2 interviewed Amanda Peltier, MD, Professor of Neurology, about the correlation between head trauma and ALS following the diagnosis of former Titans running back Chris Johnson.
Two different parties, two strikingly similar immigrant stories. Lawmakers from both parties share what being American means
NJ lawmakers approve extra mental health support for schools
New Jersey lawmakers approved a plan to expand school-based mental health services over the coming years, a priority for Gov. Mikie Sherrill, who is expected to sign the bill.
Donors were misled by Trump-backed Freedom 250, House Democrats allege
The lawmakers’ report alleges that Trump allies worked to divert funds away from America250, a bipartisan effort to mark the nation’s semiquincentennial.
NC lawmakers consider changes to vehicle child seat laws
A child passenger restraint systems bill that would put more emphasis on a child’s height is moving slowly through state Senate committees.
Jessica Tarlov: Even if this is just politics, do better
‘The Five’ co-hosts discuss lawmakers clashing during a sanctuary city hearing.
NC lawmakers send bills targeting gangs, mental health evaluations to Stein
The House of Representatives on Wednesday passed two bills targeting criminal suspects: one would change where they are evaluated for mental illness while the other would give prosecutors stronger tools to crack down on gang activity.
The moment Anthropic convinced me it’s serious about science
AI Prognosis: The release of Claude Science suggests big model makers are getting serious about real science, and not just flashy problems.
Lawmakers takes another crack at easing privatization of youth sports
House bipartisan committee addresses private equity’s "vertical integration" that has youth sports costs soaring. What might come out of the hearing?
Lawmakers must put women’s health, dignity and lives ahead of politics
Each year since the fall of Roe, the Louisiana Legislature has advanced increasingly aggressive versions of the state's abortion ban, often under the guise of targeting bad actors.
Lawmakers must put women’s health, dignity and lives ahead of politics
Each year since the fall of Roe, the Louisiana Legislature has advanced increasingly aggressive versions of the state's abortion ban, often under the guise of targeting bad actors.
WATCH: Angel mom turns tables on sanctuary politicians with basic question about their priorities
Jessica Gorman told lawmakers her daughter Sheridan “was not a talking point" as she accused sanctuary city leaders of failing to protect American citizens.
Anthropic unveils drug discovery plans alongside Claude Science, an AI tool for drugmakers
At an event on Tuesday, the AI heavyweight said it plans to target "neglected" diseases.
House backs Massie's push to release taxpayer-funded sexual harassment settlement records
Rep. Thomas Massie forced a vote on a resolution requiring public disclosure of taxpayer-funded sexual harassment settlements involving House lawmakers.
Lawmakers Criticize Private Equity’s Influence in Youth Sports
A House hearing Tuesday probed private equity’s role in the rising cost of youth sports.
Anthropic launches AI drug discovery program, joining tech giants in betting on healthcare
Anthropic will start an internal drug discovery program, part of a new push to sell artificial intelligence tools to drugmakers.
Anthropic launches AI drug discovery program, joining tech giants in betting on healthcare
Anthropic will start an internal drug discovery program, part of a new push to sell artificial intelligence tools to drugmakers.
Trans Sports Ruling Puts Pressure on States Without Bans
Almost half of states do not prohibit trans girls and women from competing. The Supreme Court ruling doesn’t force them to, but lawmakers and voters could change that.
Politics: High Cost Of Healthcare And The Political Fallout
Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Politics: High Cost Of Healthcare And The Political Fallout
Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Bailey campaign embraces artificial intelligence in new era of politics
State lawmakers consider requiring campaigns to disclose AI-generated ads
Xbox Pulls Out of ‘Project Fantasy’ Video Game From IO Interactive
The ‘007: First Light’ makers had teamed up with Xbox for the new video game
Will NC lawmakers oppose Trump’s funding ask without Helene money?
A number of North Carolina Republicans say they will oppose the White House's funding request because it doesn't include money for Helene recovery.
My MAHA Monday at the Great American State Fair | WSJ Politics Newsletter for June 30
Plus, the Supreme Court tells President Trump he can’t fire Lisa Cook, and why Jamie Dimon wants to finance missile makers
Wauwatosa business calls for lawmakers to save hemp
In November, most hemp in Wisconsin will be illegal. Wisconsin's estimated $700 million-dollar industry will shut down.
Georgia lawmakers give businesses a boost in court battles
A year after overhauling court rules to help companies avoid massive jury verdicts, Georgia legislators have made legal battles easier, shorter and cheaper for businesses.
Florida lawmakers help bring KIDS Act across House finish line
The online safety package boosts privacy protections for minors and still allows states to impose further restrictions.
Opinion | Protect the workers who protect our health
Massachusetts lawmakers should pass bipartisan workplace violence reforms before the legislative session ends.
ERISA’s Important but Limited Role in Health Care Cost Containment
Executive Summary Rising health care costs have brought renewed attention to the Employee Retirement Income Security Act of 1974 (ERISA) as policymakers and advocates look for new ways to address increasingly expensive employer-sponsored coverage. Leveraging requirements under ERISA appears attractive because other cost-containment efforts have had limited success, making the statute seem like a potential […]
Former McCarthy aide details Trump’s expletive-laden attacks on lawmakers and the wild fight to put McCarthy in office
Democrats wrestle with race, populism and ideology in clashes with lawmakers of color
The Democratic Party is confronting its long-standing dilemmas over identity and ideology as it wrestles with populist challengers in communities of color.
Democrats Wrestle With Race, Populism and Ideology in Clashes With Lawmakers of Color
WASHINGTON (AP) — After democratic socialist Claire Valdez defeated an establishment-backed candidate in New York's congressional primary last week, her elated supporters quickly turned their attention to a new target. “You're next!” they chanted when an image of House Democratic leader Hakeem ...
Patients can save thousands with drug coupons, but only if insurers honor them
Patients who rely on co-pay assistance from drugmakers are typically heavy users of health care for whom delays in treatment or worsening conditions can lead to higher costs, according to patient advocates.
If a Lyme disease vaccine gets approved, how would it go over? We asked hunters
Drugmakers are working on a potential new shot to prevent the tick-borne illness. How might it fare in the era of vaccine skepticism?
California health insurance tax hike: Will your premiums increase?
A balance act: To help fund the safety net, lawmakers have voted through a health tax extension that could increase premium costs for Californians with private insurance.
Politics Unplugged Podcast: Headlines with Stacy Pearson and Marcus Dell’Artino
The Politics Unplugged panel breaks down a possible Arizona special session tied to ESA vouchers, union protections and ballot measures. The discussion centers on whether lawmakers could unwind late-night legislation that angered teachers, police and firefighters. They also examine Gov. Katie Hobbs’ political leverage and why both parties may have reasons to cut a deal. Later, the podcast turns to Trump tax cuts, Democratic Socialists, the White House reflecting pool controversy and the World Cup.
Lawmakers say White House demolition debris at East Potomac Park poses health risk
Democratic lawmakers are urging the Trump administration to remove demolition debris from East Potomac Park Golf Course, citing health concerns, while the administration says the site poses no public health risk.
Congress Revives SAFE Banking Bill For Cannabis Businesses
A bipartisan group of lawmakers has renewed the push to let banks serve state-legal cannabis businesses without fear of federal penalties.
Volkswagen reportedly planning to axe 100,000 jobs
Volkswagen, one of the world’s largest automakers, is reportedly planning to axe as many as 100,000 jobs over the next few years, representing 15% of its global workforce.
WATCH: House Democratic leaders hold hearing on fair elections and voting rights
House Minority Leader Hakeem Jeffries and Democratic lawmakers held a hearing Thursday on defending fair elections and voting rights.
Business Council deliberations continue with four bill drafts
Lawmakers on the Joint Appropriations Committee spent another day diving through the Wyoming Business Council’s dealings. This time, they also reviewed draft bills that would influence how the council operates.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
The Politics Hour: The big winners in MD's primary elections
Leading Democratic nominee for Montgomery County Executive Will Jawando talks about his message to voters, dark money, and data centers. Plus, Tara Jackson wins the Democratic nomination for Prince George's County State's Attorney and WAMU's Alex Koma on D.C. lawmakers greenlighting the budget.
Dunleavy vetoes some health and education increases approved by Alaska lawmakers
Alaska Gov. Mike Dunleavy canceled funding increases for a variety of state health and education programs on Wednesday, vetoing a combined $57.8 million in general-purpose money from state budget bills passed by the Legislature.
Two NC lawmakers, a Democrat and a Republican, push Congress to delay SNAP changes
Above the federal penalty threshold, NC could owe $140M a year, putting at risk a program that helps over 1.2 million North Carolinians.
Supreme Court protects pesticides from some health claims in key Roundup case
The Supreme Court on Thursday restricted Americans’ ability to sue pesticide makers over alleged health harms stemming from their products. In a 7-2 ruling, the court held that some claims that pes…
Memphis People in Business for June 25, 2026
A look at promotions, hirings, movers and newsmakers in the Memphis area business scene
Micron and Qualcomm forecasts ignite $400 billion AI chip stock rally
Shares of chipmakers surged late on Wednesday, adding over $400 billion in market value after strong forecasts from Micron Technology and Qualcomm breathed fresh life into Wall Street's recently waning AI stock rally.
Newsom visits SF Mexican restaurant for 1st meeting with Becerra
The two lawmakers chatted over a mid-morning meal on Wednesday.
IHSA reacts as lawmakers propose bill requiring oversight on girls' sports impact
A new bill in Springfield would seek to overturn an IHSA decision to change the girls' high school flag football season
Rand Paul questions USPS business model as postmaster general seeks reform
Kentucky Senator Rand Paul is questioning the United States Postal Office’s (USPS) business model following the appearance of the agency’s postmaster general before lawmakers.
Science Day 2026 at the HLPF: The science-policy imperative in the final stretch to 2030 and beyond
Science Day convenes scientists, policymakers and societal actors at the HLPF to examine science's role in accelerating SDG delivery to 2030.
UConn Business Researchers Discover Voluntary Corporate Climate Goals Are Viewed Favorably by Investors
'For company decisionmakers, there is clearly no argument for not considering it'
Buffalo Bills Should Still Target These 3 Playmakers for Josh Allen
Even with the NFL offseason coming close to an end, the Buffalo Bills should look to add one of these three playmakers for Josh Allen.
House gives final approval to bipartisan housing bill aimed at lowering costs
Lawmakers in both parties are eager to show progress on affordability issues ahead of this year’s midterm elections
Automakers could halt car sales in California without delay in vehicle tracking law
A group representing major automakers warned on Tuesday that car companies may be forced to halt sales of both new and used vehicles in California on July 1 unless the state delays vehicle technology rules that aim to prevent perpetrators of domestic violence from tracking survivors.
Lawmakers call for answers from Wyoming Business Council leader
After slashing the agency's budget, legislators examine the state's role in economic development.
NC students bring calls for school funding, mental health support to legislature
Students from across North Carolina urged lawmakers to invest more in public schools, citing concerns including mental health services
Sportico Studio’s New Video Experience Debuts at Cannes Lions
Sportico this week launched Sportico Studio, a dedicated content and creative solutions offering for brands looking to engage the sports business community. The studio, featured on a new video page on Sportico’s homepage, will leverage Sportico‘s unique position at the center of the sports business ecosystem, connecting brands with influential decision-makers across leagues, teams, media, …
Utilizing Toy Chest, Part III: How Ravensburger Connects Business Strategies with Philanthropy
Learn how Ravensburger North America, one of the world’s leading game and puzzle makers, partners with TTF’s Toy Chest to create meaningful impact for children in need and reinforce the company’s commitment to social responsibility.
Markets Recoil in Global Sell-Off Driven by Tech Stocks
Chipmakers led the way down in South Korea, where the main index crashed 10 percent. Stocks in Europe were lower and S&P 500 futures pointed to a sharp fall.
New tax rules for sports bettors, entrepreneurs and others proposed in NC
North Carolina lawmakers are considering dozens of changes to tax law that could affect industries and people around the state, the result of months of closed-door negotiations among GOP leaders.
Pentagon seeks $80 billion from Congress for Iran war
The Pentagon has told lawmakers it needs roughly $80 billion, mostly to cover the cost of the war in Iran
'You're picking who gets protected': Scientists raise concerns about beachfront hardened structures
The N.C. Coastal Resources Commission's Science Panel draft report was released as the state Senate is considering rolling back the long-standing ban on structures like seawalls and groins along the coast. The scientists warned policymakers to be cautious about changes.
Cloudflare teams up with big browsers to help websites tell welcome from unwelcome visitors
Makers of Chrome, Edge, Firefox back bot-fraud defense called Private Access Control Tokens
How This Common Painkiller Is Stopping Cancer From Spreading, Scientists Reveal - Futura-Sciences
Guess Who? The Painkiller Hiding a Secret Weapon Riddle: it’s in countless family medicine cabinets. It’s the go-to when fever or pain strikes. For more than half a century, scientists have known about its anticancer properties. Some even believe it might lower the risk of metastases—those are the little troublemakers...
A New Bill Would Ban Lawmakers From Betting on Politics and Elections in Prediction Markets
CNBC’s Emily Wilkins reported last week that House lawmakers have introduced legislation that would prohibit members of Congress, their spouses, and dependent children from placing wagers in prediction markets on political, policy, or election outcomes. “House lawmakers are just dropping a brand new bill that would ban lawmakers from making any bets in prediction markets ... A New Bill Would Ban Lawmakers From Betting on Politics and Elections in Prediction Markets
Asheville film event to spotlight mental health, raise funds for counseling services
Filmmakers from across the Carolinas will be taking stage in Asheville as a regional film event aims to spark conversation about mental health.