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Damaged boxwood plants? Try these alternatives
Box Tree Moths are affecting gardens throughout the state and country Last year these insects were spreading out of these communities more aggressively. When they invade the truly catch homeowners off guard.
What’s Behind the Push to Make Schools Adopt the Science of Reading?
Restrictive laws about reading instruction repeat historical patterns of trying to privatize and centralize what happens in the classroom.
2 supermassive black holes may collide 100 years from now — and Earth would feel it
In a galaxy 500 million light-years away, two supermassive black holes could merge, spreading gravitational waves across the universe.
How Elizabeta Gjorgievska Joshevski built a global tech career and is now shaping AI strategy for enterprises
Elizabeta Gjorgievska Joshevski explains how EverCognitive helps companies approach AI transformation with strategy, readiness, and measurable business outcomes.
Ohio readies $5M fine against Kalshi for unlicensed sports betting: Capitol Letter
The prediction market operator is waging a multistate battle over whether its sports offerings should be treated as state-regulated gambling or federally regulated financial swaps.
NYSUT releases statement on ELT's Science of Reading Program
NYSUT announces continued improvements to its Science of Reading program, reinforcing its commitment to high-quality literacy instruction and educator support across New York.
Gov. Kathy Hochul’s pathetic 'science of reading' fiasco
Credit Gov. Kathy Hochul with recognizing that New York needs to drastically up its game when it comes to teaching kids to read — but mock her for paying the state teachers' union to produce a...
JBAB’s public health team tackles preventative care
Bolling Medical Squadron Public Health ensures the medical mission readiness for military members, federal civilian employees and military families throughout Joint Base Anacostia-Bolling and supporting agencies in the National Capital Region by eliminating preventable hazards before they reach the community.
Fund science, downtown living expensive, protect America
I enjoyed reading the article about how Artemis II “captivated Americans young and old across political divides, bringing unity of wonder, hope and pride to a nation torn by partisan
The political power of Latin America's first ladies
First ladies in Latin America are more than ceremonial figures. They influence public policy, advance political careers, and build power within the core of the executive branch – without a formal mandate, or accountability. Carolina Guerrero Valencia shows why ignoring them means misreading presidential power itself
Kyndryl Introduces Sovereignty Readiness Assessment and Solutioning to Support Business Continuity
/PRNewswire/ -- Kyndryl (NYSE: KD), a leading provider of mission-critical enterprise technology services, today unveiled Kyndryl Sovereignty Solutioning, a...
Building a mission-ready DAF mental health enterprise for the future fight
Air Force Medical Service leaders advanced the efforts to align mental health policy, training and leadership practices to mission readiness requirements outlined in the Department of War’s 2026 National Defense Strategy, during the Mental Health Leadership and Readiness Symposium in Orlando, Florida, on March 9-12.
EDC and Business Impact NW to host two free workshops on capital readiness for businesses
Submitted by the Economic Development Council.
1 in 10 health ad dollars go to sites spreading misinformation
Advertising on health misinformation websites reached $336.4 million, with $35.7 million from public health entities, threatening credibility in health info.
Nintendo Prime: Nintendo is spreading fake information internally to patch leaks
Nintendo is an extremely secretive company but in recent weeks they’ve sprung some leaks and it isn’t the first time that it has happened. YouTuber Nintendo Prime says he has heard from his sources…
Jelly Roll’s Blood Test Results Are a Wake-Up Call: What Blood Tests Should Your Family Actually Be...
Jelly Roll’s blood panel results stunned his doctors. If you manage your family’s health, his story is worth reading.
Cynicism, Performances And Reading’s Faltering Playoff Bid
A broader check-in from Sim on his own mood, and that of the fanbase, as Reading’s playoff bid appears to be faltering.
Student-Led Fresh Check Day Promotes Importance of Student Mental Health - University of New Haven
A public health capstone course empowers students to design and lead an evidence-based mental health initiative, building peer-to-peer support and enriching campus awareness and suicide prevention readiness.
The state is racing to implement nearly $200 million in rural health transformation projects
Also in Final Reading: A pop star in the People’s House.
April Arts and Entertainment Calendar
Poetry with Garrett Ashley & Zoë Fay‑Stindt – 3 p.m. April 4 City Lights Bookstore hosts a poetry reading featuring Garrett Ashley (debut collection “Habitats”) and Zoë Fay‑Stindt. More information at: https://citylightsnc.com/event/2026-04-04/poetry-garrett-ashley-zoe-fay-stindt Piano Duo Recital: Dr. Leonidas Lagrimas and Dr. Michael Langer – 7:30 to 8:30 p.m. April 7 Pianists Leonidas […]
ArtsGala to showcase Wright State students’ artistic growth with elegant entertainment extravaganza
Wright State ArtsGala returns Saturday, April 11, in the Creative Arts Center, offering an evening of performances, fine dining and a silent auction to support student scholarships in theatre, dance, music, motion pictures and visual art. Continue reading →
Arlington Supports Businesses Ahead of World Cup 2026™
In the latest episode of “Arlington Welcomes the World,” City experts shared key guidance on permits, planning and business readiness ahead of the tournament.
What the 'Science of Reading' Movement Has Meant for English Learners (Opinion)
We should think of reading instruction for multilingual learners as a bridge, not a checklist.
Lots of Social Science Won’t Replicate. Does That Mean It’s Bunk?
Scholars are debating the results of an effort to assess hundreds of papers’ credibility. Where some see failure and cause for urgent reform, others see reason for hope.
How Sisters in Public Health is changing who gets to lead
Angela Frazier had a vision. As a master’s student in public health, she looked around at the women in her program and saw something that troubled her. Talented, committed women were navigating a demanding field largely on their own, without mentors who looked like them, without spaces to process the weight of the work, and … Continue reading How Sisters in Public Health is changing who gets to lead
National Public Health Week: How do we contribute to public health in our community?
[vc_row][vc_column][vc_column_text css=””]Clean drinking water; safe food and milk; seatbelts and safer road design; smoke-free indoor air; the peace of mind not having to worry about smallpox or polio – these are just a few of the ways that public health makes us all safer. Each year during the first full week of April, the American … Continue reading
Naval Medicine Readiness and Training Command Cherry Point Celebrates National Public Health Week
In honor of National Public Health Week 2026, Navy Medicine Readiness and Training Command celebrates our Preventive Medicine and Occupational Health teams.
Google Brings Vertical Tabs and Improved Reading Mode to Chrome
Google today updated its Chrome browser with support for vertical tabs, which are displayed in a sidebar instead of at the top of the browser. The tab layout can be changed by right clicking on any Chrome window and choosing the "Show Tabs Vertically" option. Sidebar tabs feature full page titles and make it simple to organize tab groups. Google has also added a new full-page interface for reading mode.
Google Chrome rolling out vertical tabs and fullscreen reading mode
Google is introducing two big updates for desktop Chrome with vertical tabs and immersive reading mode. Both features are rolling out...
Chrome is finally getting vertical tabs
Google Chrome's latest update brings vertical tabs and a cleaner Reading Mode to help manage cluttered browsing.
MHR Roundup: Monday, 4/6
Your end-of-day recap for 4/6/2026 of everything worth reading, watching, and talking about in Broncos Country.
RSV is still spreading, prompting states to extend the immunization period
Respiratory syncytial virus is continuing to spread later into the spring than usual, driving most states to extend the window for RSV immunizations for eligible infants and toddlers.
What impact is the science of reading having so far in Ohio classrooms and on college campuses?
The science of reading is being taught in classrooms across Ohio, but the state's education department stresses it will likely take time to track students' progress.
On plant health and embracing new plant-breeding techniques in South Africa
The major challenge currently confronting South Africa’s agriculture is the spread of foot-and-mouth disease. For many farmers across the country, the most urgent tasks are both securing sufficient vaccines and rolling them out quickly in the coming months, particularly as the beef and dairy industries continue to suffer big losses. There is also pressure on sheep, goats, and other livestock to prevent the disease from spreading. As efforts to get the country through this monumental challenge continue, I believe it is important to sharpen our focus on the broader task at hand: strengthening biosecurity. This covers both animal and plant health. In recent years, we haven’t focused much on plant health, except a few times, such as when we had a goss’s wilt scare in the maize industry, a few cases of citrus black spot, or cases of sclerotinia in sunflower seeds. But the fact that South Africa managed to control the outbreaks of these particular diseases when they occurred a few years ago was due to organized agricultural and government scientific capabilities, and, most importantly, the availability of crop protection or agrochemicals necessary to address some of them. Therefore, as the animal health division in the Department of Agriculture focuses on the pressing challenge of the day, the foot-and-mouth disease, there is an opportunity for the plant health division to assess if they have all the requirements to tackle any outbreak that may occur on fruits, vegetables or crops in future. The challenge with crop diseases is that they can spread quickly and cause much more rapid damage in the field than we typically see with livestock. Therefore, speed is everything in ensuring the appropriate controls are available. I raise this as an important area, particularly given the drastic climate variation we observe across the country. The production conditions in some areas have changed noticeably over time, which may introduce new risks. The other essential part is ensuring that South Africa has access to the best crop protection technology available in the market. Many technology developers worldwide have operations in South Africa. Therefore, the Department of Agriculture, along with the Agricultural Research Council, must continuously interact with technology developers to assess the various crop protection technologies they are releasing globally and determine their suitability and need in South Africa. This will require a proactive approach from the government, unlike the current approach, in which technology developers typically approach regulators with new technologies. The government, recognising the food security risks, must take a proactive approach to ensure that South African farmers have access to the latest crop protection technologies, thereby safeguarding the country’s food security. Beyond crop protection, we must never forget that South Africa’s agriculture is key to ensuring that the country is the most food-secure country at the national level in sub-Saharan Africa. South Africa is also the only African country in the top-40 global agricultural exporters, having more than doubled since 1994 on the back of the adoption of high-yielding seed cultivars. South Africa has been the only African country to adopt a bold approach to embracing science and adopting genetically engineered seeds for grains and oilseeds in the early 2000s. Since then, we have seen crop yields improve noticeably, contributing to the gains we mentioned above. But ensuring that South Africa improves further is not a given. The key lies in South African regulators’ attitudes towards new technologies. We have to maintain a progressive approach and not give in to the politics of non-food and non-scientific voices that shout on the sidelines. Food security is national security, and the government must ensure we progress, leaning on science. Therefore, the registration of high-yielding new genomic techniques is required. South Africa cannot afford to fall behind the EU, the USA, South America, and many of its competitors in global agriculture. The Department of Agriculture’s crop science division must adopt a progress-and-science-embracing approach for the good of the country. Thanks for reading AgriView! Subscribe for free to receive new posts and support my work. Subscribe Share
No Time to Read, Plenty to Say
In an era where information is increasingly packaged as entertainment and consumed rapidly, the transmission of meaning has become more fragile. Writers, technologists, and institutions alike are realizing that communication is a complex interaction shaped by audience habits, digital tools, and shifting cultural norms. Each alteration not only affects what we know but also how we understand. The result is a growing tension between expression and interpretation. One that challenges our assumptions about knowledge, attention, and responsibility in the modern world.
Artemis II Flight Day 5: Crew Demos Suits, Readies for Lunar Flyby
The Artemis II crew of NASA astronauts Reid Wiseman, Victor Glover, Christina Koch, and CSA (Canadian Space Agency) astronaut Jeremy Hansen, continue their workday aboard the Orion spacecraft.
DHS shutdown, HB 8002, State of the Bears: CT politics news
Plus: Updates on family planning clinic funding, an ambitious reading pitch, and a proposed penalty for replacing workers with AI.
Math Needs Its 'Science of Reading' Moment (Opinion)
A psychologist explains how discovery-first math falls short.
Celebrate Science Day Takes Off at New Location: Reading Regional Airport
From helicopters to birds and the principles that lift them skyward, guests of all ages will discover how things fly while also enjoying a wide range of interactive STEM activities beyond aviation.
As manufacturing jobs decline, Vermont business leaders take their concerns to the Statehouse
Also in Final Reading: Budget battles, crime victim notifications and endorsements.
How Will Reading’s Playoff Rivals’ Seasons Pan Out?
Jamie has a crack at predicting how the teams around Reading will fare in the rest of the season.
Author Mary Roach to speak on weird science, human anatomy at Lawrence event
Mary Roach, a popular science writer with a funny bone, will talk in Lawrence about her new book on weird science and human anatomy, as part of a public library reading series.
Mortgage rates rise for fifth straight week as Iran war continues to roil markets
The average rate on a 30-year fixed mortgage rose this week to 6.46%, according to the latest Freddie Mac data released Thursday. That is up from last week's reading of 6.38%.
Huddersfield Town vs Reading: 2025/26 Match Preview
In the first of two Easter fixtures, the Royals head north to take on playoff chasers Huddersfield Town.
Faced with Trump's attacks on research, French scientists urge vigilance
On Thursday, March 26, the Stand Up for Science collective condemned the Trump administration's attacks on research and academic freedom. They also warned of the risks of these actions spreading to Europe and France.
Colorado business leaders are still negative about the future economy, though less so than last year
CU business school’s survey ranked geopolitical concerns as the top reason for feeling negative about the second quarter. Also: Use of AI at work is spreading.
Bishop Museum of Science and Nature readies for Artemis II launch Wednesday
The Bishop Museum of Science and Nature is gearing up to give space fans a front-row seat to the Artemis II rocket launch Wednesday evening, offering a mix of live viewing, immersive programming and hands-on learning.
Town Meeting voters urged lawmakers to consider a universal health care bill. What can that change in Montpelier?
Also in Final Reading: Labor board rejects return to office, a forensic facility and AI in health care.
Apple releases iOS 18 security update for all iPhone users, update now
Apple has released a rare iOS 18 update to patch a spreading exploit for all iPhone users still running iOS 18.
The best new popular science books of April 2026
April has a lot to offer when it comes to popular science reading, promising to help us do everything from future-proof our brains courtesy of Hannah Critchlow, to get to grips with really big numbers, thanks to Richard Elwes
Google Readies Screenless Fitbit Band to Rival Growing Whoop Craze
Alphabet Inc.’s Google is developing its own fitness band, aiming to compete with screenless wearable devices from upstarts like Whoop Inc. and Oura Health Oy.
Reducing tobacco and nicotine use key to ‘having a healthy, fit force’
The Military Health System has long offered multiple tobacco cessation programs, which are now even more important for readiness, says a top Department of War medical leader.
Contract for license plates readers 'automatically renewed,' Troy mayor says
the contract for the Flock license plate-reading cameras and software was "automatically renewed," Mayor Carmella Mantello said.
Military Health Care in Korea: What You Should Know
Moving to Korea is an exciting assignment filled with new opportunities, experiences, and adjustments. One of the first questions many arriving service members and families ask is simple: How does health care work overseas? The good news is that U.S. military beneficiaries stationed on the Korean Peninsula have access to a comprehensive health care system that combines American military medicine with one of the most advanced civilian health networks in the world. Through Military Treatment Facilities (MTFs) operated by the Army, Air Force, and Navy -- along with TRICARE Overseas host nation providers and hospitals -- patients receive coordinated, high-quality care designed to support readiness while keeping families healthy throughout their tour. Here’s what to expect when receiving care in Korea.
Hearts 'agonisingly close' to possibility of winning league
In a world of modern technology - where smart watches track your steps, heart rate and more - any Jambos that own one will find the past few weeks make for some interesting reading. At the Dundee game the other weekend, my watch pinged an alert telling me I was in a "stressful period" and needed to calm down. The fact we'll be taking more than 7,000 supporters to the Spaghettihad/Parmesan des Princes (or whatever it's known as these days) is an absolute testament to the job McInnes and the players have done, with Jambos fully behind the team right now.
Something really big is going to happen': NASA's historic Artemis II mission approved for April 1 launch
NASA has given the 10-day Artemis II mission the green light after its flight readiness review, and the weather outlook remains favorable.
Phantom science
There’s a new specter haunting environmental governance, and it doesn’t rattle ghostly chains, it’s its generating phantom science. Recently, I was reading a government report trying to find scient…
Ruby Ridge Book Explores Roots of American Conspiracy Politics at Vroman’s Tonight
Author Chris Jennings will discuss his critically acclaimed book “End of Days: Ruby Ridge, the Apocalypse, and the Unmaking of America” at Vroman’s Bookstore on Monday, March 30, in a 7 p.m. conversation with journalist and author Jim Newton, a Pasadena resident. The book, published in February by Little, Brown and Company, examines the 1992 Ruby Ridge standoff — in which federal agents surveilled a cabin in Boundary County, Idaho, as part of an operation to arrest white separatist Randy Weaver — and traces a line from that 11-day siege to the conspiratorial politics that now mark American public life. By the time Weaver surrendered, his wife, his son, and a U.S. Marshal were dead. Jennings, a former editorial staffer at The New Yorker and the author of “Paradise Now: The Story of American Utopianism,” argues that the strain of apocalyptic Christianity that gripped the Weaver family can be traced to biblical prophecy readings dating to the 1870s and through the rise of 20th-century fundamentalism, according to the publisher’s description. The events at Ruby Ridge, Jennings contends, acted as an accelerant for this worldview. The New York Times Book Review called the book a thoroughly researched chronicle written with precision, according to a review published in February. Kirkus Reviews described it as a vivid reconstruction of a pivotal moment in the history of right-wing extremism. Newton, who will lead the conversation, spent 25 years at the Los Angeles Times as a reporter, editor, bureau chief, and columnist, including a stint as editor of the editorial pages from 2007 through 2010. He is the author of four books, including biographies of Chief Justice Earl Warren and Gov. Jerry Brown. Newton teaches at UCLA, where he founded Blueprint magazine, and is a columnist for CalMatters. He received the American Political Science Association’s
How Michigan leaders should rethink strategy amid uncertainty
Experts say leaders must shift from prediction to preparation, embedding foresight and crisis readiness to navigate constant uncertainty effectively.
Killing off the Regional Transportation District
This column is appearing the same day state Sen. Matt Ball (D) of Denver and his legislative co-sponsors unveil legislation implementing many of the recommendations advanced by last summer’s RTD Accountability Committee. Although it isn’t readily apparent, they have allowed themselves to be enlisted in a plot that will likely lead to the bankruptcy and […]
Navigating the social media minefield
Scientists and researchers seeking to announce promising findings, exchange ideas or contribute to policy discussions outside of academic circles may find social media an expedient tool.But increasingly, scientists and other professionals are discovering that online platforms can be a double-edged sword: while sharing their work and expertise is crucial for visibility and meeting funder expectations, it also exposes them to baseless criticism and even accusations of spreading false information."It is getting harder and harder for scientists, and researchers in general, to convey their findings without facing attacks on their legitimacy and accuracy of their research," says Valère Ndior, a professor of public law at the University of Western Brittany in Brest, France, who has spent more than a decade studying misinformation on social media. Researchers attempting to challenge deceptive online information may themselves be accused of political bias or not being objective in their research, he explains, adding that some scientists disengage because they feel overwhelmed and unable to sustain meaningful dialogue. "It is quite sad to see in some instances that researchers end up leaving social media altogether because they feel like the pressure is getting too intense or feel threatened," he says.Ndior, a past president of the Francophone Network of International Law, is also involved in European efforts to make science and research findings more accessible to the public. As an ambassador for the Science Comes to Town (SCTT) project, he has participated in recent discussions on public perceptions of science and online misinformation. The European Commission-funded initiative connects Brest and two other cities — Kiel in Germany and Split in Croatia — and aims to strengthen ties between communities, universities and research institutions to promote science awareness and cooperation across Europe.Coordinated campaigns around contentious topicsNdior draws a clear distinction between critical thinking and thoughtless criticism. Yet he sees online discussions being increasingly shaped by suspicious behaviour and coordinated information campaigns — including "raids" aimed at dominating discussions and "astroturfing," where small groups act as larger movements to sway debates. Tracking these patterns has become harder because some platforms have restricted data or charge for it, despite provisions of the European Union's Digital Securities Act aimed at ensuring researchers can have access to such data. According to Ndior, "platforms became more reluctant from the moment access to data became a legal requirement rather than a voluntary initiative."Unfounded claims and scepticism about science existed long before Internet chat groups. But the noticeable rise in online hostility has intensified around contentious topics, such as the coronavirus pandemic and climate change, alongside the weakening of gatekeepers to moderate content.For Ndior, dubious claims about pandemic countermeasures and vaccine safety highlighted the struggle between "balancing freedom of expression and the protection of public health and order." Efforts to remove social media content deemed false or risky for public health triggered accusations of censorship and the silencing of legitimate discussion, and in some cases, legal challenges.Concerns about attacks on the credibility of scientists and researchers have generated a flurry of academic papers in recent years and prompted professional communities to address ways to counter online attacks. Such unease extends to the generation that has grown up with digital media. Ndior points out that his students, some of whom research artificial intelligence regulation, hate speech, online surveillance and other controversial topics, hesitate to share their work or viewpoints online. "Many of them don't want to expose themselves too much because they don't feel ready to be faced with the backlash of other people criticising their research," he explains.Safer harbours for engagementLegal challenges against false or defamatory posts are not necessarily a solution — especially given the trans-jurisdictional nature of the Internet. Lawsuits also take time and money, and if they fail, can be counterproductive. Instead, Ndior advises scientists and researchers to be selective in how and where they communicate. Professional online platforms and moderated discussion spaces offer a better environment for engagement. He also highlights the value of more traditional formats, such as radio interviews and in-person discussions at schools, libraries and science fairs, which encourage dialogue with the public. "Personal contact makes a big difference," he says, while acknowledging that these approaches lack the global reach of social media.Ndior’s interest in digital law and online misinformation stems from his time as a doctoral student in international law in the early days of social media. He began analysing posts from governments and heads of state to determine if they could be considered official and thus used as evidence in litigation. His work attracted media attention and led to conference and speaking invitations. "This was not part of my plan," he says, "but this is what happens as a researcher — your interest is sparked by a certain event or phenomenon, and it suddenly becomes your focus."Ndior believes SCTT provides "a double benefit" for researchers, enabling them to connect with peers and interact with the public. "There is a wide community of people who are not in academia who are critical thinkers looking for opportunities to ask questions, to get information and contribute their ideas,” he says. "I really value that kind of feedback."Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.
Navigating the social media minefield
Scientists and researchers seeking to announce promising findings, exchange ideas or contribute to policy discussions outside of academic circles may find social media an expedient tool.But increasingly, scientists and other professionals are discovering that online platforms can be a double-edged sword: while sharing their work and expertise is crucial for visibility and meeting funder expectations, it also exposes them to baseless criticism and even accusations of spreading false information."It is getting harder and harder for scientists, and researchers in general, to convey their findings without facing attacks on their legitimacy and accuracy of their research," says Valère Ndior, a professor of public law at the University of Western Brittany in Brest, France, who has spent more than a decade studying misinformation on social media. Researchers attempting to challenge deceptive online information may themselves be accused of political bias or not being objective in their research, he explains, adding that some scientists disengage because they feel overwhelmed and unable to sustain meaningful dialogue. "It is quite sad to see in some instances that researchers end up leaving social media altogether because they feel like the pressure is getting too intense or feel threatened," he says.Ndior, a past president of the Francophone Network of International Law, is also involved in European efforts to make science and research findings more accessible to the public. As an ambassador for the Science Comes to Town (SCTT) project, he has participated in recent discussions on public perceptions of science and online misinformation. The European Commission-funded initiative connects Brest and two other cities — Kiel in Germany and Split in Croatia — and aims to strengthen ties between communities, universities and research institutions to promote science awareness and cooperation across Europe.Coordinated campaigns around contentious topicsNdior draws a clear distinction between critical thinking and thoughtless criticism. Yet he sees online discussions being increasingly shaped by suspicious behaviour and coordinated information campaigns — including "raids" aimed at dominating discussions and "astroturfing," where small groups act as larger movements to sway debates. Tracking these patterns has become harder because some platforms have restricted data or charge for it, despite provisions of the European Union's Digital Securities Act aimed at ensuring researchers can have access to such data. According to Ndior, "platforms became more reluctant from the moment access to data became a legal requirement rather than a voluntary initiative."Unfounded claims and scepticism about science existed long before Internet chat groups. But the noticeable rise in online hostility has intensified around contentious topics, such as the coronavirus pandemic and climate change, alongside the weakening of gatekeepers to moderate content.For Ndior, dubious claims about pandemic countermeasures and vaccine safety highlighted the struggle between "balancing freedom of expression and the protection of public health and order." Efforts to remove social media content deemed false or risky for public health triggered accusations of censorship and the silencing of legitimate discussion, and in some cases, legal challenges.Concerns about attacks on the credibility of scientists and researchers have generated a flurry of academic papers in recent years and prompted professional communities to address ways to counter online attacks. Such unease extends to the generation that has grown up with digital media. Ndior points out that his students, some of whom research artificial intelligence regulation, hate speech, online surveillance and other controversial topics, hesitate to share their work or viewpoints online. "Many of them don't want to expose themselves too much because they don't feel ready to be faced with the backlash of other people criticising their research," he explains.Safer harbours for engagementLegal challenges against false or defamatory posts are not necessarily a solution — especially given the trans-jurisdictional nature of the Internet. Lawsuits also take time and money, and if they fail, can be counterproductive. Instead, Ndior advises scientists and researchers to be selective in how and where they communicate. Professional online platforms and moderated discussion spaces offer a better environment for engagement. He also highlights the value of more traditional formats, such as radio interviews and in-person discussions at schools, libraries and science fairs, which encourage dialogue with the public. "Personal contact makes a big difference," he says, while acknowledging that these approaches lack the global reach of social media.Ndior’s interest in digital law and online misinformation stems from his time as a doctoral student in international law in the early days of social media. He began analysing posts from governments and heads of state to determine if they could be considered official and thus used as evidence in litigation. His work attracted media attention and led to conference and speaking invitations. "This was not part of my plan," he says, "but this is what happens as a researcher — your interest is sparked by a certain event or phenomenon, and it suddenly becomes your focus."Ndior believes SCTT provides "a double benefit" for researchers, enabling them to connect with peers and interact with the public. "There is a wide community of people who are not in academia who are critical thinkers looking for opportunities to ask questions, to get information and contribute their ideas,” he says. "I really value that kind of feedback."Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.
Coeur d'Alene Pediatrics readies for move to Heritage Health
Coeur d’Alene Pediatrics officially becomes part of Heritage Health this spring. “We've been talking about it for about a year,” Heritage Health CEO Mike Baker said. “We spent time trying to figure this out what makes sense for the community and really protect what Coeur d’Alene Pediatrics has been doing forever.”
Release Engineer Completes Data Science Online Courses
This spring a release engineer completed three Coursera Data Science courses from Johns Hopkins and the Software Carpentry instructor training, each roughly four weeks long. The courses covered The Data Scientist's Toolbox, R Programming, and Getting and Cleaning Data, and required substantial external reading to finish programming assignments. The training emphasized R, GitHub, reproducible research, and evidence-based teaching methods applicable to managing distributed systems.
Netflix's Barren, Empty April Schedule Is The Future Of Entertainment
It’s no secret that Netflix is the largest streaming platform in the world. Over the last 10 years, it’s been … Continue reading "Netflix’s Barren, Empty April Schedule Is The Future Of Entertainment"
St. Louis readies for 3 home sports games on the same day
Tens of thousands of sports fans are expected to fill downtown St. Louis this weekend for a rare overlap of professional football, baseball and hockey games.
Riverhead may revive condemnation of L.I. Science Center building
Riverhead officials say time may be up for the long-delayed science center project, signaling readiness to revive condemnation of the Main Street building.
Giant golden spiders could spread this summer, experts downplay health risk
Joro spiders, which have 4-inch leg spans, are spreading across the eastern U.S., and Penn State says they could reach Pennsylvania. Experts say not to panic, as they're shy and rarely bite.
New COVID 'Cicada' Variant Is Spreading — What Experts Want You To Know
By HealthDay Staff HealthDay ReporterFRIDAY, March 27, 2026 (HealthDay News) — Another new COVID variant is starting to spread. Health officials say the variant — known as BA.3.2 or "Cicada" — has been quietly circulating for years but is now being detected more often in the United States and around ...
In spreading itself across five cities, Stranger than Heaven might not lean as heavily on one of Like A Dragon's key strengths as I expected
Stranger than Heaven takes place across five different years and five different Japanese cities, RGG Studio have revealed.
New COVID-19 variant, ‘Cicada,’ spreading in US, health officials say
Health officials are closely watching a new COVID variant after a rise in cases.
New COVID-19 variant, ‘Cicada,’ spreading in US, health officials say
Health officials are closely watching a new COVID variant after a rise in cases.
New COVID-19 variant, ‘Cicada,’ spreading in US, health officials say
Health officials are closely watching a new COVID variant after a rise in cases.
New COVID-19 variant, ‘Cicada,’ spreading in US, health officials say
Health officials are closely watching a new COVID variant after a rise in cases.
New COVID-19 variant, ‘Cicada,’ spreading in US, health officials say
Health officials are closely watching a new COVID variant after a rise in cases.
New COVID-19 variant, ‘Cicada,’ spreading in US, health officials say
Health officials are closely watching a new COVID variant after a rise in cases.
New COVID-19 variant, ‘Cicada,’ spreading in US, health officials say
Health officials are closely watching a new COVID variant after a rise in cases.
Three Dover schools recognized for Science of Reading commitment
Three Dover schools earned the 2026 Governor's Science of Reading Champions award for their literacy instruction.
Health alert issued for dengue outbreaks spreading in travel hotspots
The CDC has issued a Level 1 dengue fever warning covering 15+ countries, urging spring break travelers to take precautions against mosquito bites.
Warner's 'Sinners' Returns Atop U.K. Home Entertainment Sales Chart Following Oscars Win
Warner’s Sinners returned atop the Official Film Chart, the weekly U.K. home entertainment sales chart, after winning multiple Oscars at the March 15 Academy Awards. Last week’s chart topper, Universal’s Wicked: For Good dropped to No. 2, after four non-consecutive weeks at No. 1. Warner’s other Oscar-winner, One Battle After Another, surged 14 spots to No. … Continue reading "Warner’s ‘Sinners’ Returns Atop U.K. Home Entertainment Sales Chart Following Oscars Win"
Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Mills halts kennel ordinance at second reading amid showing for business owner
MILLS, Wyo. — Mills City Council has shelved a proposed ordinance affecting kennels and catteries on second reading. Mills City Attorney Pat Holscher told
Ten Pieces of Non-Technical Career Advice for Engineering and Computer Science Students
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U.S. Business Activity Hits 11-Month Low as War Drives Prices Higher
U.S. business activity growth slowed to an 11-month low in March while prices surged, according to a preliminary S&P Global survey released Tuesday. S&P’s composite output index, based on its surveys of services and manufacturing firms, fell to 51.4 from 51.9 in February. That was its weakest readi
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
SCOTUS conservatives signal readiness to curb late-arriving mail ballots
Conservative Supreme Court justices appeared skeptical during oral arguments of allowing states to continue counting late-arriving mail-in ballots. A decision is expected in June.
Building a Culture of Health: BJACH Opens Armed Forces Wellness Center at Fort Polk
FORT POLK, La. — Bayne-Jones Army Community Hospital marked a significant step forward in supporting warfighter readiness and community well-being with the grand opening of its new Armed Forces Wellness Center on March 23. The center, located on the first floor inside BJACH, provides Soldiers, Families, civilian employees and beneficiaries with access to personalized health assessments, education and coaching designed to improve overall health and performance.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
The reality of death and the Trinitarian “science” of salvation
Readings: • Ez. 37:12-14 • Psa. 130:1-2, 3-4, 5-6, 7-8 • Rom. 8:8-11 • Jn. 11:1-45 We live in a time of astounding scientific breakthroughs and unprecedented medical marvels. In my lifetime alone, we’ve witnessed men landing and […]
Should you try the 75 Hard challenge? Experts warn the risks may outweigh the benefits
The 75 Hard regimen demands 75 days of strict rules covering diet, exercise and reading. Experts explain what helps, what harms and smarter, sustainable alternatives.
Country music star wants a shot at Super Bowl Halftime Show: ‘Make the call’
It's been a while since a country music star landed the gig.
Apple explains why M5 chips have three different core types in new interview
Apple explains M5's three core types: super cores for single-thread tasks, performance cores for multi-threading, and efficiency cores.
China's Bank of Ningbo readies digital yuan business as Beijing expands e-CNY
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Justice Department seizes several websites it says spread terrorist propaganda
The Justice Department on Thursday seized several websites it says were used by Iran as part of “psychological operations” targeting perceived advisories and spreading terrorist propaganda.