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AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Trump’s Bombardier threat puts aerospace supply chain at risk
U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the U.S. In response, the maker of private jets noted that many components for its planes, including the wings, are produced in the U.S. and its supply chain relies heavily on U.S. companies. Since Canada-U.S. […]
Sunderland 'deserved more' at Brentford
Marco Gabbiadini says Sunderland deserved to win at Brentford after taking the game to their opponents on Saturday. The former Sunderland striker, speaking to Radio Newcastle, believes the Black Cats' attacking approach could have earned them all three points and suggested the result could prove significant when looking back at the end of the season. "If you finish the season in a similar position to what we finished last season and you look back over it, you might look back and think this is one that could have taken us another place up the table," said Gabbiadini.
Seiche Launches Marine Science And Technology Department With Three New Leaders
Seiche has established a Marine Science & Technology Department uniting marine mammal specialists, acousticians, and engineers under three new department heads. The move expands the company's scientific and technical capabilities across offshore wind, renewable energy, and broader marine environmental monitoring.
Technology Science Corporation and Integration Technologies Group Awarded NASA SEWP VI Contract in Category C
TSC and ITG continue their multi year partnership and win SEWP VI
NFL Expert Predicts Patriots Regression After Super Bowl Run
Sporting News predicts the Patriots will surrender the AFC East and fall short of another Super Bowl appearance despite winning a playoff game.
Vape waste poses risks to health and environment, analysis finds
Many disposable vapes contain extremely high levels of lead and other metals, raising new concerns over the fast‑growing piles of vape waste.
Stanley Black & Decker to sell $300M mower business
Stanley says the sale is an effort to focus on growing its biggest brands, and it will continue to make and market lawn-mowing equipment.
BUSINESS Katie Scheuber showcases their unique storytelling with Stay Tuned Productions
Almost 12 years ago, nonbinary lesbian Chicago documentary filmmaker and photographer Katie Scheuber created Katie Makes Films video, a production company to showcasing their love of visual storytelling, while still working as a social worker. In 2022, Scheuber’s wife Noemi Heras encouraged them to do the video work full time. Last year Scheuber created Stay Tuned […]
Winchester Health Department to provide School Flu Clinics for students
The following was submitted by the town of Winchester: Parents can register their children for School Flu Clinics now through Tuesday, Sept. 15 at 11:59 p.m.. You may select any open appointment time, but note that appointment times are not the actual time your student will be vaccinated.
Microsoft breaks another patch Tuesday record
Windows and security engineers have had a busy summer.
I’ve already picked my National Television Awards winners - here’s who I think will be bringing home the trophies
The competition is fierce, but I know who I want to come away from the ceremony with a gong
Arizona Diamondbacks News 9/8: Labor Yay!
Recaps from a wild Labor Day win as well as news confirming Burnes return
Scott McTominay has successful heart surgery as return timeframe revealed
Napoli released a statement on Tuesday following McTominay’s heart procedure
Preview: Eagles travel to Mainz
Eintracht are looking to claim their first league win of the season at 1. FSV Mainz 05. Adi Hütter says his players are still developing, while Mario Götze has called for maximum performance.Backdro...
Oil prices keep rising and weigh on Wall Street
U.S. stocks are drifting lower in their return to trading following a three-day weekend. The S&P 500 dipped 0.2% Tuesday. The Dow Jones Industrial Average fell 477 points, and the
Red Wings’ 2027 schedule: Earliest home opener in team’s history
ROCHESTER, N.Y. (WROC) — The Rochester Red Wings have released their 2027 schedule — and they have set the earliest home opener in their history. The team announced on Tuesday that their home opener at ESL Ballpark will be on Friday, March 26. They are set to begin playing against the Syracuse Mets. This start […]
Williams warns WRU on 'almost non-existent' student support
Former Wales and Lions wing Shane Williams says pathways support for schools and colleges from the Welsh Rugby Union (WRU) is 'almost non-existent'.
‘Plastic pollution hotspots’ spawn a public health crisis across Latin America
Since China banned the import of plastic waste in 2018, plastic pollution has been having a growing impact on the people and ecosystems of Latin America. As the region imports an increasing amount of the world’s used and discarded plastic, new research shows that waste infrastructure in many countries is already buckling under the strain […]
‘VisionQuest’ star Paul Bettany says new series is another ‘massive swing’ (exclusive)
‘VisionQuest’ star Paul Bettany interrogates the ‘intergenerational digital trauma’ of the upcoming Marvel series and talks reuniting with James Spader, who’s back as Ultron.
California’s political hopefuls remain silent on state’s job losses, unemployment
Dan Walters Commentary: The aspirants for those positions are making all sorts of promises to win voters’ approval. But few, if any, have mentioned a slow-motion menace affecting a fundamental
Preparations begin for Champions League opener in Como
The Champions League is drawing closer, with preparations now underway at Cottaweg. The Red Bulls began work on Tuesday ahead of their opening game away to Como 1907. Thursday’s 21:00 CEST kick-off ...
Kelly Ripa returns to ‘Live’ for first time in over 1 month after painful gum surgery
Kelly Ripa finally returned to ‘Live With Kelly and Mark’ for the first time in over a month, following an extended absence due to painful gum surgery.
Television Host and Entertainment Journalist Josh McBride signs with WME and secures exclusive Acast partnership as The McBride Rewind podcast accelerates national growth
The McBride Rewind, the celebrity interview podcast hosted by television personality Josh McBride, has signed with WME for representation in all areas and entered into an exclusive partnership with Acast, expanding the show's reach as it continues to gain momentum in the entertainment podcast space.
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
FOX Sports’ Nick Wright eviscerates Bills’ Josh Allen for lack of signature win
Josh Allen doesn't have a signature win according to Nick Wright.
Evaluating Warriors' Biggest Roster Weakness Ahead of Training Camp
The wings will get most of the attention when camp opens in Hawaii, but the real problem for Golden State is in the middle of the floor.
Allison Janney can’t believe what happens on ‘The Diplomat’ season 4: ‘It gave me chills’
‘The Diplomat’ isn’t slowing down in season 4. If anything, star Allison Janney tells EW ‘it ramps up’ even more.
Qualderm and Parakeet Health Partner to Expand Patient Access Across National Dermatology Network
Parakeet Health, a healthcare AI company that is transforming patient engagement at enterprise scale, and Qualderm, a management services organization for a national physician-led skin care network, today announced a collaboration to expand patient access, strengthen care continuity and reconnect patients following cancellations, missed visits, and overdue follow-ups.
Parakeet Health lands major AI partnership with national dermatology group Qualderm
Parakeet Health landed a major partnership with Qualderm, one of the nation's largest dermatology organizations, as the company looks to apply agentic artificial intelligence to a growing specialty | Parakeet Health landed a major partnership with Qualderm, one of the nation's largest dermatology organizations, as the company looks to apply agentic artificial intelligence to a growing specialty care access problem.
If the Saints win/lose vs. Lions
What either outcome means for the black and gold in Week 1.
Insider Purchase: Chief Business Officer of $NMTC Buys 33,333 Shares
David J. Wambeke, the Chief Business Officer of $NMTC, bought 33,333 shares of the company on 08-27-2026 for an estimated $66,999. This trade was reported by Quiver Quantitative using data from a recent SEC filing. This increased their holdings of this class of stock by approximately 20.0%. Following this trade, they now own 199,999 shares of this class of $NMTC stock.$NMTC Insider Trading Activity$NMTC insiders have traded $NMTC stock on the ope
Study Identifies Blind Spot In How Science Measures Breakthroughs
A new tool exposes how science's go-to metric misses breakthroughs made by two teams at once, from Darwin to particle physics.
‘Star Trek’ and NASA have intertwined legacies – the show championed diversity and inspired generations of real space scientists
60 years of ‘Star Trek’: A cultural anthropologist on how the show’s “infinite diversity in infinite combinations” conception helped shape NASA’s vision of the future.
Steve Flowers: Political reassurances and revelations in 2026
Faces and places and races change in politics, but one thing that stays the same is the candidate who has the most money for campaign advertising and vote gathering, nine times out of ten wins.
Celtic Bank Selects Jack Henry to Support Business Banking and Fintech Tech Stack
/PRNewswire/ -- Jack Henry® (Nasdaq: JKHY) announced today that Celtic Bank has selected Jack Henry to support its progressive technology strategy, allowing...
Celtic Bank Selects Jack Henry to Support Business Banking and Fintech Tech Stack
Jack Henry® (Nasdaq: JKHY) announced today that Celtic Bank has selected Jack Henry to support its progressive technology strategy, allowing the bank to choose the right tools to grow its business lines while improving user experience, efficiency, and scale.
Is conservative modernism the way forward for the right?
Anglo-American politics cries out for something better than the demagoguery and AI slop that dominate right-wing discourse. Conservative modernism offers a serious, literate alternative.
Has Tencent Music Entertainment Group (NYSE:TME) Fallen Below Fair Value?
Tencent Music Entertainment Group has seen its share price fall sharply over the past year, yet both an intrinsic value estimate based on a Discounted Cash Flow (DCF) approach and traditional earnings multiples currently point to the stock trading below those valuation checks. The disconnect between a weak recent share performance and signals of potential undervaluation is drawing attention to what the current price really implies about the business. Over the past 12 months the stock has...
MDI Health to Honor Mount Desert Nursing Association with 2026 Impact Award
BAR HARBOR—MDI Health will honor Mount Desert Nursing Association (MDNA) as its 2026 Community Partner of the Year during the organization’s Annual Meeting and Community Celebration on Tuesday, September 15. MDNA will receive the 2026 Impact Award in recognition of its longstanding commitment to providing in-home nursing, physical and occupational therapy, and medical equipment to the Island region. By caring for people where they live, MDNA helps patients remain safely and independently at home, providing reassurance and support to their families. “Mount Desert Nursing Association exemplifies the power of community partnership,” said Chrissi Maguire, President and CEO of MDI Health. “Its nurses bring skilled, compassionate care directly into people’s homes, helping patients navigate illness, recovery, and some of life’s most difficult moments. We are deeply grateful for MDNA’s service and the important role it plays in the health of our community.” MDNA works closely with MDI Health providers and care teams to support continuity of care following hospitalization, surgery, illness, or changes in health. Its personalized services extend care beyond the hospital and help ensure patients receive the support they need close to home. “For 77 years, MDNA has been here for our community, helping our neighbors recover and remain safely at home. Our long-standing partnership with MDI Health is an important part of making that possible. Together, we help ensure a seamless transition from hospital to home and provide patients with the continued care they need. We are incredibly grateful for this recognition and especially proud of our talented and hardworking team,” said Amy McVety, Executive Director of Mount Desert Nursing Association. The Impact Award will be presented during MDI Health’s Community Celebration from 5 to 7 p.m. at the Bar Harbor Club. The event will also recognize outstanding employees, volunteers, and trustees; celebrate MDI Health’s achievements over the past year; and mark a transition in Board leadership as Madeleine Braun, PhD, MBA, prepares to succeed Martha Wagner, PhD, as chair. The celebration will feature music, refreshments, the MDI Health Auxiliary Raffle, and a cash bar. MDI Health’s Annual Business Meeting will take place from 3:30 to 4 p.m. via Zoom. These events are free and open to the public, but space is limited. To reserve your spot, contact Patrianna Anderson at 207-288-5082, ext. 1432, or visit mdihospital.org/communitycelebration. Subscribe Share Leave a comment
Revealed: The 2026 Fastest Growing Companies in Greater Washington
The rankings will be announced in October.
Ancient Roman fresco and mosaic featuring maritime city unveiled at newly restored Baths of Trajan
Authorities in Rome have unveiled what is believed to be the largest fresco and mosaic complex of ancient Rome | 1010 WINS
Jaguars Predicted to Win Back-to-Back Division Titles
The Jacksonville Jaguars are looking to build on their 2025 success. At least one analyst believes they will become back-to-back division champions.
Frank Leibfarth wins 2027 Carl S. Marvel Award - College of Arts and Sciences
The award, given once every other year, recognizes outstanding accomplishments and unusual innovation in basic or applied polymer science by scientists early in their careers.
Your personality may be more genetic than scientists realized
More than 1,200 genetic variants have been linked to the Big Five personality traits, and many of the same variants are also associated with health, longevity, careers, income, and everyday habits. The findings reveal a surprisingly wide genetic connection between personality and life outcomes while showing that environment still plays a powerful role.
Democrats have lost Silicon Valley. Here's what it will take to win it back
If Democrats want to become the party of the future again, they need to stop treating the people building the future like political enemies.
Puck Drop Preview: 2026-27 Minnesota Wild
Last Word On Hockey‘s Puck Drop Previews are back for the 2026-27 season! As the regular season approaches, Last Word will preview each team’s current outlook and stories to watch for the upcoming year. We’ll also do our best to project how things will go for each team throughout the campaign. Today, we’re previewing the 2026-27 Minnesota Wild. …
Message for Mbappé? Lamine Yamal: title winners all press
Lamine Yamal has spoken at a press conference ahead of Barcelona-Feyenoord. The Champions League as a challenge"There is no greater motivation for me than winning the Champions League, it’s the most...
A young Tallahassee scientist's Alzheimer's research wins national acclaim
Lily Ma, senior at Tallahassee's Chiles High School, probed the possibility of using stem cells as a vehicle to slow or even halt the degenerative process.
Video Global report shows where US kids rank in reading, math and science
ABC News' Elizabeth Schulze has the results of a new report released this morning showing where U.S. students rank compared with students around the world.
McInnes vision becoming clear amid step in right direction
The past week or so has been faultless results-wise for Derek McInnes. It's a shame for Lawrence Shankland to facing a spell out injured after beginning to find form with three goals in two games. The transfer window overall was okay, but we can't be making bold statements on the back of three wins against teams Rangers should be beating.
Baker relishing role in Walker Cup victory
Eliot Baker says helping Great Britain and Ireland win the Walker Cup still has not sunk in.
Sherri Shepherd to join Broadway\'s \'Aladdin\' as the Genie, and she\'s \'beyond thrilled\'
Sherri Shepherd plans to join the Broadway musical “Aladdin” as the Genie. The Daytime Emmy Award-winning talk show host will take on the role from Oct. 16 to Jan. 3.
Sherri Shepherd to join Broadway's 'Aladdin' as the Genie, and she's 'beyond thrilled'
Sherri Shepherd plans to join the Broadway musical “Aladdin” as the Genie. The Daytime Emmy Award-winning talk show host will take on the role from Oct. 16 to Jan. 3. Shepherd says she’s...
Daniel Farke provides fitness update ahead of Chelsea clash
After a quick turnaround following the weekend’s Premier League draw at Brighton & Hove Albion, attentions now turn to the trip to Chelsea for Wednesday’s EFL Cup Round Three tie for Daniel Farke�...
Meghan Markle Has ‘Unfinished Business’ With This UK A-Lister Amid Feud
Meghan Markle is reportedly looking to rebuild one of her most high-profile friendships following her family’s move back to the U.K. According to a new report, the Duchess of Sussex has been quietly r...
Dodgers Owner’s MAGA Stance Leaves Los Angeles Advocate ‘Very’ Disappointed
The Los Angeles Dodgers’ owner is under local scrutiny for “sending money to Trump’s administration” following ICE crackdowns.
Orioles news: O’s snap six-game skid
The O’s pulled within three games of the Guardians with a series-opening win, but an uphill battle remains.
Cardinals’ 3rd-base Picture Coming Into Focus for 2027
After the offseason exits of Nolan Arenado and Brendan Donovan from the Cardinals organization, it opened up a pathway for Nolan Gorman to take advantage of everyday opportunities. However, that hasn’t quite come to fruition. The Cardinals optioned Gorman to Triple-A Memphis in June and put him through a vigorous rework of his swing and […]
Cricket Australia opens Big Bash to privatisation
Cricket Australia opens the Big Bash to private investment - with some owners of franchises in The Hundred showing interest.
Kerjota transformative - but has he earned a start?
If Hearts' mentality was in question after that late collapse against Aberdeen just over a month ago, Sunday's stoppage-time winner from Sabah Kerjota offered a pretty emphatic response. This was a side showing the resilience Wouter Vrancken is trying to build. VAR Andrew Dallas intervened in two major incidents missed by referee Chris Graham, while the introduction of supersub Sabah transformed hope into genuine belief.
Borussia Dortmund vs Villarreal – Predicted lineup and team news
Borussia Dortmund will be aiming to stretch their winning run to four matches in a row this season as they welcome Villarreal for their first UEFA Champions League game of the campaign on Tuesday at S...
A Haredi political revolt is brewing – and it could shake up Israel's election
Veteran Haredi politicians are losing favor with top rabbis, shaking up party slates. Meanwhile, new parties are outflanking the establishment on its left and right. But will they really be any different?
Korea Toray Science Foundation Names Kim Sang Kyu, Kim Yun Hee as Science Award Winners
The Korea Toray Science Foundation has selected the winners of the 9th Korea Toray Science
LS ELECTRIC’s Park Wins Science and Technology Medal for Power Equipment Development
Park Woo-jin, head of Global Product Development at LS ELECTRIC, received the Science and
Xbox Game Pass adds Call of Duty: Black Ops Cold War today
Xbox Game Pass is adding Call of Duty: Black Ops Cold War today, allowing players on the service to check out another entry in this popular shooter series.
Case for Gray becoming very hard to make
The optimism that followed Hibs' win in Dundee has well and truly drained from the support after two subsequent performances that fell well short of expectations. A hapless first half, where Hibs chased shadows, was followed by a second half that started brightly but ended prematurely with a ridiculously self-inflicted red card. The promising start to the campaign has quickly evaporated with losses to Gent, Hearts and now St Johnstone.
Millwall's Metcalfe & Bolton's Sheehan win appeals
Millwall midfielder Jenson Metcalfe and Bolton’s Josh Sheehan have their red cards from Saturday’s game between the sides overturned on appeal.
'It just can't be happening'
Everton fan Sarah Halpen has criticised the club's hierarchy for being "reactive" rather than "proactive" in the summer transfer window. The Toffees' business, which saw a £40m deal for forward Folarin Balogun collapse late on deadline day, has left manager David Moyes with just 18 senior outfield players until the next transfer window which opens on Friday, 1 January.
Filipe Luís confirms Monaco’s continued Erik Lira pursuit
AS Monaco manager Filipe Luís has said that he will “continue to want Erik Lira in every transfer window”. It comes after the Principality club missed out on the Mexico international this summer....
Colts' Shane Steichen Gives Alec Pierce Update for Week 1
Indianapolis Colts wide receiver Alec Pierce recently returned to practice following ankle surgery, but will he be ready for this Sunday against the Baltimore Ravens?
Haste ye back to full health, gaffer
This column is usually filled with bad takes, daft footballing opinion and poor attempts at humour, but today I want to be a little more serious. The gaffer, Jim Goodwin, is going through a health issue at present. As a player, Goodwin was never my favourite, in fact, he likely wasn't anyone's favourite.
Haste ye back to full health, gaffer
This column is usually filled with bad takes, daft footballing opinion and poor attempts at humour, but today I want to be a little more serious. The gaffer, Jim Goodwin, is going through a health issue at present. As a player, Goodwin was never my favourite, in fact, he likely wasn't anyone's favourite.
List of DVD release dates for Sept. 8 and beyond
Following is a partial schedule of coming movies on DVD. Release dates are subject to change: SEPTEMBER 8: Minions & Monsters 8: Supergirl 8: Passenger 8: Leviticus 8: Batman: Knightfall
The future of Burke Lakefront Airport could depend on who wins Ohio’s midterm elections
Mayor Justin Bibb's push to close Burke Lakefront Airport needs an act of Congress — and Ohio's competitive midterm races could determine whether that's possible.
The future of Burke Lakefront Airport could depend on who wins Ohio’s midterm elections
Mayor Justin Bibb's push to close Burke Lakefront Airport needs an act of Congress — and Ohio's competitive midterm races could determine whether that's possible.
Boomerang hiring is growing. Here's why CEOs like it.
More workers are returning to their former employers. CEOs say boomerang hires bring experience, connections, and other benefits.
Grammy-winning country music star suffers medical emergency, postpones shows
The country music legend's daughter shared the news on social media.
Maine cancer survivor sharing wellness, health lessons in new app
Tom McGowan of Windham is using what he learned during treatment to help better the lives of people around the world.
NFL QB Legend Kurt Warner Has Blunt Message to Sports Critics
Kurt Warner has seen the pressure that comes with professional football from nearly every possible angle, and the NFL legend recently delivered a blunt message to sports critics. The Hall of Fame quarterback expressed frustration with the growing tendency to attack athletes online as though performing under extraordinary pressure should be effortless. Warner acknowledged that […] The post NFL QB Legend Kurt Warner Has Blunt Message to Sports Critics appeared first on Gridiron Heroics.
Bakewell aims to settle some unfinished business at the Tackle Warehouse Pro Circuit Championship
The Tackle Warehouse Pro Circuit Championship at the Kissimmee Chain features a sterling field, and while everyone in the field has the talent to win, there are a handful of favorites. But most of those high on the list aren’t from Florida – this year’s Toyota Series event on Kissimmee was won by Northeasterner Alec Morrison, and […]
Can William Lawrence, a Progressive, Flip a Key Michigan House Seat?
William Lawrence, a progressive challenging a first-term Republican, is trying to rewrite the playbook for Democrats running in swing districts.
Why Democrats’ priorities shifted from abortion to affordability in Bucks County’s key midterm races
Democrats in Bucks County are fine-tuning their message ahead of must-win races in November. Reproductive rights had once been center stage in recent campaigns
Why VCs are questioning AI companies' big revenue claims
Investor skepticism is growing around the revenue claims powering the AI boom.
Streaming ad loads are increasing this year on Netflix, Hulu, and more
Ad-supported streaming services are showing more commercials per hour amid a profit push in Hollywood.
Music legend considering leaving the U.S. because of Donald Trump: ‘I’m not aboard’
The eight-time Grammy Award winner made the revelation during a recent interview.
Swing FORE Women's Health tournament raises more than $16,000 for Hahne Cancer Center patients
DuBOIS — The Treasure Lake Women’s Golf Association’s annual Swing FORE Women’s Health golf tournament raised more than $16,000 to support local cancer patients and their families.
Gayle Benson buys another well-known New Orleans skyscraper, adding to growing property holdings
“There is tremendous opportunity in New Orleans, and investment creates confidence, confidence creates opportunity, and opportunity creates jobs and economic growth," Benson said. "We want to be part of that process and continue doing our part."
What is the Ballon d'Or? Award history and why it matters so much to soccer players
Every October, the Ballon d'Or is a huge bone of contention for soccer fans around the globe, as the prestigious award prepares to add another superstar to its list of all-time great winners.
Now is perfect time for Sebastian Tounekti to step up
Time for Sebastian Tounekti to step up. It’s essentially now or never for Celtic’s inconsistent Tunisian winger…5th September 2026; The Marbill Coaches Stadium, Paisley, Scotland; Scottish Premi...
Is Nunes out of favour?
The role of Matheus Nunes in Enzo Maresca's team has been the subject of several questions sent in via our Manchester City Ask me Anything form. Nunes has not featured much this season because he has sustained a couple of knocks in recent weeks - and that has led to Abdukodir Khusanov being deployed at right-back. The Portugal international limped out of the Community Shield defeat by Arsenal just minutes before kick-off and played half an hour in the opening Premier League win over Bournemouth.
Politics we can agree on: Small wins show the positive impact of government
This week I’d like to shine a light on some of the under-the-radar happenings in DC that we should all agree are positive steps forward.
Alonso thought 'outside the box' against Arsenal
BBC Radio 5 Live's Monday Night Club team have been discussing Chelsea boss Xabi Alonso's "brave" and "fascinating" approach to defending Arsenal's corners. The Spaniard suffered his first defeat as Blues manager on Sunday, as Mikel Arteta's side came from behind to earn a 2-1 win at Emirates Stadium. On Sunday, Chelsea employed a tactic of leaving four players upfield for defensive corners, going man for man in the penalty area.
Jose Mourinho: Will Real Madrid begin their Champions League campaign with a win against Inter?
Jose Mourinho begins his second Real Madrid spell in the Champions League against former club Inter Milan, 16 years after winning the trophy with Inter at the Bernabeu. Will he finally deliver European glory in Madrid?
UK-US trade could suffer as a result of sanctions for illegal Israeli settlements, American ambassador warns
UK foreign secretary to reassert support for Palestinian rights and a two-state solution in move drawing criticism from US and Israel
Zverev eases into US Open quarter-finals
Top seed Alexander Zverev has reached the quarter-finals of the US Open to become the only man to reach the last eight at all four Grand Slams this year. The French Open winner advanced after a 6-2, 6-2, 7-6 (7-3) win over Italy's Luciano Darderi on Monday evening.
Two key details emerge on Arsenal's recall clause for Nwaneri
It was recently reported that Arsenal have an option to recall Ethan Nwaneri from his loan spell at Borussia Dortmund during the January transfer window.However, local outlet Ruhr Nachrichten has now ...
The Lowdown On Bournemouth's EFL Cup Opponents Lincoln City
Lincoln head to Bournemouth hoping a cup upset is on the cards. The Imps have made a decent start to life in the Championship following promotion, while its anticipated the Cherries will be much changed for this one, so Bournemouth may need to tread carefully in this one.
UK commits £100m to bolster Ukraine’s air defences over winter
Package of military equipment includes Patriot missiles, supplies of which have dwindled amid Russian attacks