SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " CEO " 3,314 found 🔀 AI-powered Shuffle
Home Depot’s CEO Leave Is a Reminder Every Business Needs a Succession Plan
Organizations can navigate unexpected leadership change by planning for uncertainty and preparing detailed succession plans.
Lamborghini's pricey Revuelto SV supercar debuts at Monterey with scarcity as its strategy, CEO says
Lamborghini brought its most extreme car to the lawn at the Quail, A Motorsports Gathering - the Revuelto SV, a 1,050-horsepower naturally aspirated hybrid V12 that the company calls the most powerful and fastest production car in its history.
Lamborghini's pricey Revuelto SV supercar debuts at Monterey with scarcity as its strategy, CEO says
Lamborghini brought its most extreme car to the lawn at the Quail, A Motorsports Gathering - the Revuelto SV, a 1,050-horsepower naturally aspirated hybrid V12 that the company calls the most powerful and fastest production car in its history.
5 Insightful Analyst Questions From PENN Entertainment’s Q2 Earnings Call
PENN Entertainment delivered results for Q2 that met Wall Street’s revenue expectations and produced a significant upside in non-GAAP earnings per share, prompting a positive market reaction. Management emphasized the strength of the retail casino segment, highlighting record revenues driven by recently completed property development projects and increased demand from mid- and high-value customers. CEO Jay Snowden cited broad-based momentum, noting, “Our best-in-class property level management t
5 Small Business Ideas You Can Launch for Less Than $5,000
There are plenty of small business ideas with less than $5,000 in startup costs. Just ask the Inc. 5000 CEOs.
D23 2026: Disney Reveals What’s Next in Entertainment
At D23: The Ultimate Disney Fan Event, CEO Josh D’Amaro welcomed fans as Disney unveiled exclusive first looks, major announcements, and upcoming entertainment releases.
Gender-affirming care, Russia sanctions, Kalshi: CT politics news
Plus: A ruling on HUD funding, Connecticut's CEO-worker pay gap, 'Sales-Tax-Free' Week and a storm forces a Ryan Fazio event to relocate.
‘I shot Mr Thompson’: Luigi Mangione describes his planning and the killing of health insurance CEO
It was a dramatic twist to the federal case over the killing of UnitedHealthcare’s Brian Thompson – but state charges are still pending
Who Is Cami Clark? Anthropic CEO’s Wife Asked Epstein To Invest In Porn Business
Clark approached Epstein after he had already been convicted for soliciting prostitution.
American College of Cardiology leader named CEO of Society of Thoracic Surgeons
Justine Varieur Turco held several leadership positions with the American College of Cardiology over the years. She is also a former Cardiovascular Business editor.
Luigi Mangione admits killing healthcare CEO and pleads guilty to federal charges
"I shot Mr Thompson in Manhattan and he died," the 28-year-old said after pleading guilty to charges of stalking resulting in death.
Luigi Mangione pleads guilty to killing health insurance CEO Brian Thompson
“I shot Mr. Thompson, and he died,” the 28-year-old said
Disney CEO Josh D'Amaro Says ABC Is 'Not Going to Be Told How to Run' Its Business Amid FCC Fight
"We're going to stand up to what we believe is journalistic integrity," the Disney CEO tells CNBC
FBI seized devices from Guggenheim CEO Mark Walter, top deputy: report
Federal scrutiny of the Chicago-based investment giant reached Walter and Guggenheim President Dina DiLorenzo months before Walter struck a $12.5 billion deal to sell the Lakers.
Luigi Mangione to appear in court for expected guilty plea in killing of UnitedHealthcare CEO
Luigi Mangione is scheduled to be in federal court Friday for a hearing at which he's expected to plead guilty in connection with the 2024 killing of UnitedHealthcare CEO Brian Thompson, according to a person familiar with the matter.
Gary Vaynerchuk on the rise of alternative sports, surging sports team valuations
Gary Vaynerchuk, VaynerMedia CEO and VaynerX chairman, joins 'Squawk Box' to discuss the rise of alternative sports, surging sports team valuations, and more.
MHA CEO Report — Strong Hospitals Help Build Strong Communities - MHA | Michigan Health & Hospital Association
Hospitals are often discussed in relation to their impact on patients, but their influence extends much further. Beyond providing care, hospitals help communities attract employers, support local jobs and provide the services families need to live and work in Michigan. Last week, the MHA released the 2026 Economic Impact of Healthcare in Michigan report
Flutter Entertainment’s Q2 Earnings Call: Our Top 5 Analyst Questions
Flutter Entertainment’s second quarter results were met with a significant negative market reaction, reflecting investor concerns about profitability despite solid revenue growth. Management pointed to deliberate investments in the U.S. business—especially increased customer promotions and the rollout of an expanded loyalty program—as factors that weighed on near-term earnings. CEO Peter Jackson acknowledged, “We recognize that this weighs on near-term earnings, but we're convinced it's the righ
More Than Half of CEOs Say Local Governments Don't Support Business. That's a New Low
According to Inc. 5000 data, chief executives say local government isn't embodying a business-friendly mindset. Some experts attribute the shift to one key event.
Medtronic veteran named CEO of medtech startup Versa Vascular
Bill Shields, who spent a 15 years with Medtronic’s structural heart division, will now be helping lead a startup focused on tricuspid valve treatments.
BREAKING: Netflix to shut down two more game studios
Netflix is sticking with video games but once again reducing the number of studios it owns making games. The streaming giant is closing Los Angeles-based Night School studio, which it acquired in 2021 and plans to close Helsinki-based Moonloot, which was founded in 2022. Just six weeks ago, Night School had released Unhinged, a novel 30-minute first-person horror game, streamable on TVs to Netflix users. The game was hailed by Netflix co-CEO Greg Peters in a call with investors. Six weeks later, Night School is closing. Prior to its Netflix tenure, Night School had developed the award-winning supernatural thriller Oxenfree. A second Oxenfree game followed after the purchase, as well as a mobile game designed to tie in to an episode of the Netflix show Black Mirror. Netflix attributed the studio closures to a prioritization around kids gaming, party games, story-driven fare and games with mainstream hooks, such as a recently released FIFA game. “We see an opportunity to be more focused in our execution, so we are making organizational changes to the business to match those priorities,” a Netflix spokesperson told Game File. Netflix is also cutting jobs from its internal games team. A rep declined to say how many jobs were being lost by these cutbacks. “We are incredibly grateful to the talented colleagues we’re saying goodbye to today. We thank them for all their contributions to Netflix, and wish them the best,” the rep said. Netflix started releasing video games, initially on mobile as a free bonus to subscribers, in 2021. By 2023, Mike Verdu, then the head of Netflix’s game operations, was telling me that the company was committed to growing carefully, as it offered more games and built up internal game studios. At the time, it hadn’t made any gaming job cuts. Since then, Netflix has altered its approach. In 2024, it shut down Team Blue, a start-up studio led by ex-Call of Duty and Halo developers that was exploring making a high-end first-person game for the service. Last October, Netflix shut down another studio, Boss Fight, shortly after Peters praised the team’s Squid Game game to investors. (One of Boss Fight’s main developers now works on the Netflix FIFA game for outside studio Delphi.) And in December, Netflix sold cozy game studio Spry Fox back to its founders. Amid all of this, Netflix has shifted from emphasizing mobile games to offering games through TVs and PCs, via streamed connections, with phones used as controllers. That’s how Night School’s Unhinged worked, along with games such as Boggle and Party Crashers that have collectively helped the Netflix game controller app chart well on mobile app stores. The studio cuts leave Netflix with a central gaming team that works with external developers, and a dedicated first party studio in, Helsinki-based Next Games, which produced many of the company’s couch-centric party games. The move away from having a roster of internal game studios aligns with Netflix’s own approach to shows and movies, which are largely produced externally. The company owns few TV/film production studios of its own. The gaming industry overall is seeing large holders of multiple studios cut back, with Sony, Ubisoft, Embracer, Microsoft and other giants closing or selling off studios. Cuts in California-based studios, where costs often run relatively high, have been particularly acute. Netflix has faced skepticism about its gaming plans for years. The moves today are likely to fuel them, and the company has few upcoming projects to counter the narrative. Among the few hinted, acclaimed independent studio Don’t Nod said last year it was working on a game tied to a major Netflix franchise.
Business Spotlight: San Diego Solar helps people take control of their energy future
As solar energy becomes more accessible to more residents and business, San Diego Solar has been there to meet customer needs and help shape the future of energy. In a Q&A, CEO Curtis Williamson discussed trends in solar over the years,…
Flock tightens safeguards on surveillance cameras after backlash
On Thursday, CEO Garrett Langley outlined new safety and privacy changes for the surveillance camera network "that came from listening."
Cisco CEO Chuck Robbins on Q4 results: All areas of our business have tailwinds right now
Cisco Chair and CEO Chuck Robbins joins 'Squawk on the Street' to discuss the company's quarterly earnings results, strength of the company's business, AI order & revenue outlook, and more.
Saber CEO Makes Rideshare's Undisclosed AI Mess Even Worse
Matt Karch said a missing Steam disclosure will be added eventually
Saber Interactive's CEO Matt Karch Can Get In The Bin
'I would frankly in retrospect have been happy to replace her with AI'
Electrovaya: ‘Underlying Business’ is profitable despite missing earnings projection
Electrovaya’s third quarter revenue was not what company officials expected, but Dr. Raj DasGupta, Electrovaya’s CEO, is still bullish on his company’s future. Electrovaya reported fiscal third-quarter 2026 revenue of $17.7 million, missing Wall Street estimates by over $3 million and prompting a lowered full-year revenue outlook to between $70 million and $73 million. The […]
CNBC Sport: Pro Padel League CEO explains business of rapidly growing sport
CNBC's Alex Sherman sits down with Michael Dorfman, CEO of the Professional Padel League.
Joe DiMaggio Children’s Hospital CEO is no longer with Memorial Healthcare System
Caitlin Stella, who has been the CEO for Joe DiMaggio Children’s Hospital for the past eight years, is no longer in that position as of Tuesday, the South Florida Sun Sentinel has learned..
NYC Health + Hospitals/Jacobi | North Central Bronx Receives $600,000 for New Ophthalmology Microscope
NYC Health + Hospitals/Jacobi | North Central Bronx CEO Christopher Mastromano announced today that, thanks to the generous support of Borough President
Fans Try To Decipher The Elder Scrolls VI’s Censored Subtitle
Xbox CEO Asha Sharma just played 'The Elder Scrols VI' and both she and Bethesda are censoring its subtitle with a specific number of letters.
Bob Iger and Josh Kushner to buy the Lakers
In a statement, former Disney CEO Bob Iger and venture capitalist Josh Kushner said they "were deeply honored" by the opportunity.
Elon Musk Says AI Will Be SpaceX's Biggest Business by September: Does the Math Check Out?
SpaceX (NASDAQ:SPCX) CEO Elon Musk says artificial intelligence will overtake everything else the company sells as soon as next month. In an all-hands meeting, Musk said AI revenue “will exceed all other SpaceX revenue probably in September, like next month,”...
Astorg Acquires Thermo Fisher Microbiology Business, Forms Independent Company
Astorg has completed its acquisition of Thermo Fisher’s microbiology business, which will operate independently under CEO Dirk Bontridder.
Beyond The Swamp: Your guide to 2026-27 Gators sports
Tucked in between Saturdays in The Swamp and camping in front of the Stephen C. O’Connell Center for basketball games are national championship contenders, Olympians, rising stars and some of the most exciting sporting events on campus. Whether you’re looking for a fun new activity, an indoor escape from the Florida heat or your next favorite team, here’s what you need to know before every Gator season begins.
Whoop CEO Will Ahmed on Medicare expansion: 'We're excited about where the business is going'
Whoop CEO Will Ahmed discusses the wearable technology company's expansion into CMS Medicare, reaching over 3 million members, and launching natural cycles integration on 'Mornings with Maria' with Maria Bartiromo.
Thrivent CEO Terry Rasmussen: Everything I need to know about business I learned from cleaning people’s teeth
‘You can have expertise, but if people don’t trust you, it doesn’t go very far.’
Xbox CEO Asha Sharma's internal playthrough of The Elder Scrolls 6 disrupted by a giant inflatable rat, as Bethesda union protests cuts
The CWA video games union brought a giant inflatable rat as well as red flags marking each laid off employee.
Science of Speed opens at Kamin Science Center
Pittsburghers tested their driving skills during the opening of Science of Speed at Kamin Science Center.
Amanda Janoo wins Vermont’s Democratic governor primary
The economist, who was virtually unknown before announcing her campaign, beat out Aly Richards, the former CEO of a prominent child care lobbying and advocacy group.
Xbox CEO Asha Sharma Gushes About Elder Scrolls VI, Does Not Seem To Notice Giant Rat On Bethesda Office Lawn
Please clap (instead of talking about layoffs)
St. Anthony Hospital names new chairman amid relocation effort
Dr. Peter McCauley, currently a strategic adviser for healthcare private equity firm 2Flo Ventures, will replace the hospital's former CEO Guy Medaglia.
Xbox Boss Praises Elder Scrolls 6 As Bethesda Devs Protest Outside
The newly appointed Xbox CEO posted on social media that the upcoming RPG looks 'incredible'
Xbox CEO Gets Elder Scrolls 6 Demo, Teases the Subtitle
Xbox CEO Asha Sharma got to see a "live playthrough" of The Elder Scrolls 6, and she posted her reactions on social media afterwards. She also teased – in the vaguest of ways – the subtitle for the upcoming RPG.
Bradley Tusk says ‘IT’S VERY HARD’ to support Mamdani amid anti-business climate
Tusk Ventures CEO Bradley Tusk weighs in on the impact of NYC Mayor Zohran Mamdani’s policies on businesses.
Bradley Tusk warns Zohran Mamdani's anti-business policies hurt NYC jobs
Tusk Ventures CEO Bradley Tusk joins Stuart Varney to discuss New York City Mayor Zohran Mamdani's anti-business policies in New York City. Tusk warns Mamdani's class warfare rhetoric chases away major employers and hurts local NYC jobs.
GXO CEO Patrick Kelleher: Data centers are a big business, and they’re growing for us
GXO CEO Patrick Kelleher joins 'Squawk on the Street' to discuss ringing the NYSE opening bell, the logistics business, marking five years since the spinoff, data centers, and more.
Kalshi CEO slams founders for being over-reliant on ‘mostly trash’ business advice—he founded his now-$22 billion prediction market as a college grad
Kalshi’s 30-year-old CEO says most business advice is ‘trash’—he doesn’t read management books or listen to podcasts: ‘I’m gonna make it up as I go’
Dodge's CEO Says The Best Is Yet To Come: 'We're Going To Go Faster'
Matt McAlear discusses the 600-hp Charger Super Bee, the upcoming GLH, and what’s next for the SRT brand.
AI-Native, Not AI-Sprinkle: Why AI Is A Business Change, Not A Technology Change
Companies unlock AI’s biggest productivity gains not by adding AI tools to existing workflows, but by redesigning teams, roles and daily work around AI. The broader lesson, argues Bob Morse, co-founder and managing partner of Strattam Capital, is that achieving transformational gains like 3x productivity requires CEO- and board-backed organizational change — not merely technology adoption.
Canva’s Former CFO Says AI Cannot Fix A Broken Business
More than half of CEOs report no measurable AI return. The CFO who scaled Canva from $10 million to $2 billion says the problem was never the model you picked.
Business Chief Opens Speaker Applications for CXO Summit 2026
London, 11 August 2026 - Business Chief, a BizClik Media brand, has opened speaker applications for the CXO Summit 2026, inviting Chief HR Officers, People & Culture Leaders, Chief Marketing Officers, Chief Finance Officers and CEOs to join its flagship executive event. The summit, which brings together C-suite leaders to address critical challenges facing modern enterprises, from AI disruption to economic uncertainty. The event has already secured an impressive lineup of speakers from global or
ERAM Holdings Appoints Alok Kumar as CEO to Lead Human Capital Management Business in India
ERAM Holdings, a leading diversified conglomerate headquartered in the Kingdom of Saudi Arabia, is pleased to announce the appointment of Alok Kumar as Chief Executive Officer – ERAM HCM India.
$100 GTA VI Ultimate Edition Surpasses Standard Edition in Pre-Orders
Grand Theft Auto VI is leading the charge in the $80 AAA race, which has understandably upset many gamers, but the $100 Ultimate Edition has been another point of contention in online discussions. However, despite the online discussions potentially suggesting otherwise, Take-Two CEO, Strauss...
Saber's newest game trailer takes a shot at Gearbox's CEO, if you look closely
The first hint that something might be up with the recent debut trailer for Saber Interactive’s Rideshare Stimulator is an unusual choice of words—aside from that second one in the game’s title. “Don’t take your passengers too seriously,” the trailer’s narrator says, as he describes this upcoming game. It a car game about the gig work of driving eccentric people to their destinations, a riff on Crazy Taxi. And then, he says: “When I think I’ve met the randiest of passengers, someone even stranger gets in.” “Randiest”? That suggests “randy,” which usually means having strong sexual desire. Yet none of the oddball backseat occupants featured in the trailer seem particularly lustful. One is an old man who considers his grandson a failure, another shares the theory that birds might control traffic lights, another says he’s banned from an aquarium. A little later, there’s a license plate, shown 63 seconds into the trailer, on the front of an SUV: USB DRV It’s a Texas plate. The symbol between those letters is a cog wheel. If you know, you know. That’s a reference to Texas-based Borderlands game development studio Gearbox Software (their logo features a cog wheel). More specifically, it’s a reference to Gearbox’s CEO Randy Pitchford, who in 2018 found himself explaining the nature of video he’d saved on a USB drive that was found at a Medieval Times restaurant before being returned to the studio: “It was ‘barely legal’ porn. This girl’s handle was ‘Only 18.’” The “girl” in the video had committed a solo sex act that Pitchford, an avid practitioner of magic, found remarkable. “I realized, this is not a sex worker…This is a fucking magician.” Back then, the USB drive was central to competing lawsuits against Gearbox by the studio’s former lawyer and by Gearbox against him. A settlement in late 2019 “exonerated” Pitchford, per the Hollywood Reporter. The USB story has resurfaced at times, now in a trailer from a company that not long ago was corporate brethren with Gearbox. Saber vs. Gearbox The head of Saber told Game File that the reference is payback. “The dig is because Randy took shots at Embracer in Borderlands 4,” Saber CEO Matt Karch told me when I asked him about the license plate. “Without Embracer, Randy is performing magic tricks at birthday parties for a living.” Having interviewed Karch during a cross-country flight in late 2024, I can confirm that Karch was unimpressed with Pitchford during their time both working in the Embracer group. I’d approached him not out of surprise that there was animosity but that it was manifesting publicly now. Gearbox was founded in 1999, worked on a port of Halo early on, and developed hit series such as the loot-based sci-fi shooter Borderlands before it was purchased by The Embracer Group in early 2021 for $363 million (with a possible earn-out of over $1 billion, if certain targets were hit by 2027). Saber was founded in 2001, worked on a remaster of Halo early on, had a big hit with zombie shooter World War Z and was purchased by Embracer in early 2020 for $150 million, with a potential earn-out of up to $375 million. For a few years, the Embracer group was a voracious acquirer of game studios. Then, as investment dried up, it choked. In March 2024, Embracer sold Saber to an investment company controlled by Saber CEO Matt Karch, and it sold Gearbox in an all-stock deal to long-time Borderlands publisher Take Two Interactive. Other studios were shut down. Hundreds of developers were laid off. Gearbox didn’t say much about their Embracer experience, nothing too direct, at least. In the summer 2024, Pitchford told reporter and occasional Game File contributor Nicole Carpenter that Borderlands 4’s story was in some way thematically connected to Gearbox’s experience at Embracer: “There’s this cultural and emotional shift in me, personally, and at the studio. What does it mean to trade some autonomy for organization?” When Borderlands 4 came out, there was something stranger: the matter of “Embracer’s Bluff,” a location in the game featuring an AI-powered toilet and a large trash dump, according to a detailed Kotaku account of the place. Gearbox never commented on it; Take Two never got back to me about it when I asked them last year. By contrast, since Saber exited Embracer, Karch has been one of Embracer’s biggest defenders, casting their management as well-meaning and supportive despite the layoffs and studio closures that resulted from their excessive expansion. Like others, Saber’s Karch saw Embracer’s as a shot. With Rideshare Stimulator’s trailer, he’s returned fire. “It’s amazing to me how fast people forget those who went above and beyond for them,” Karch told Game File. A rep for Gearbox did not comment by press time. Game File is a reader-supported publication. Your backing makes my reporting—including any coverage of trailer-based beefs—possible. Good news! I’m currently running Game File’s first big sale of 2026. You can get a one-year subscription for 23% off. Click here to take advantage of the limited-time offer. And thank you for your support! Item 2: In brief… 🚫 Wal-Mart has laid off the staff of Restart, a games media outlet launched in 2024, Aftermath reports. 🟥 A GTA VI preview is on the way, at last, via an “extended look” that will premiere, unusually, on Netflix at 3pm ET on August 27, then officially go live elsewhere six hours later. Last week, Game File noted that Take Two label Rockstar Games is overdue for showing off GTA VI, based on the timing of the initial hands-off previews of GTA V and Red Dead Redemption 2. During a call with investors, Take Two CEO Strauss Zelnick said pre-orders for GTA VI were “unprecedented and astonishing,” but added the company can’t predict how many of those pre-orders represent bonus sales vs. sales that otherwise would have been made at launch. During the same call, Zelnick was noticeably bullish on the future of playing games over streaming cloud connections (predicting wider adoption in three or so years). He sounded unbothered by Sony’s plans to stop making discs for new games (he said the business is 90% digital already and predicted that there could still be limited edition physical editions of games “in the same way there’s still vinyl in the recorded music business.”) 👀 Take Two wrote off $43 million in their spring quarter after deciding “not to proceed with further development of an unannounced title in its pipeline from a third-party developer.” 🤔 Some rare age-demographics from a big publisher: Capcom recently told investors that “users in their 20s account for approximately half of the users of both Pragamata and Resident Evil Requiem.” Item 3: The week ahead Tuesday, August 11 Game releases: The Elder Scrolls IV: Oblivion Remastered (Switch 2; already out for PC, PS5, Xbox) continues the Bethesda strategy of putting Elder Scrolls games on everything; Royalty Free-For-All is a Smash Bros.-style fighting game featuring public domain characters such as Mother Goose brawling with Oliver Twist in a stage based on the original Little Shop of Horrors movie. Wednesday, August 12 Game release: Pro Jank Footy (PC, console) is an arcade-style Australian Rules Football game with increasingly ridiculous rules, the more you play (I enjoyed the Steam demo) Thursday, August 13 Game release: Super Mario Sunshine (Switch 2, originally released in 2002 on the GameCube) is released for Switch 2’s Nintendo Switch Online service. This game is the black sheep of 3D Mario games. It’s the successor to the breakthrough Super Mario 64 and the rare Mario game built around a single (vacation resort) theme. Mario’s got a water-spraying backpack, a Yoshi pal and a lot of blue coins to collect.
Mamdani's Business Council Is Taking Shape With 5 Big Names. Some CEOs Reportedly Said No
Chobani founder Hamdi Ulukaya and AlleyCorp founder Kevin Ryan have joined three finance veterans on the list of reported invitees.
Kevin Blair on Georgia Business Banking and Synovus Growth
Synovus CEO Kevin Blair shares how the regional bank is driving business growth across Georgia through relationship banking, technology, and a people-first approach to customer service.
3 key details about Mark Zuckerberg's vision for your AI future
Meta CEO Mark Zuckerberg says personal AI agents could reshape work, help launch smaller companies, and make entrepreneurship more accessible.
Bose CEO Lila Snyder on the fight for high-quality audio
Snyder on the company’s move into luxury audio, licensing the Bose brand, and what happens to great sound in the AI era.
Mission-Driven Mondays: Morris Museum builds community through art, science and curiosity
Morris Museum President and CEO Tom Loughman shares how the Morris Township institution uses art, science and performance to build community.
Accendra Health CEO to retire by end of the year
Accendra Health announced Monday that President and CEO Edward A. Pesicka plans to retire by the end of the year.
Accendra Health CEO to retire by end of the year
Accendra Health announced Monday that President and CEO Edward A. Pesicka plans to retire by the end of the year.
2026 Outstanding Women in Business
Last year, Mainebiz launched the Outstanding Women in Business awards, building on the longtime Women to Watch program. Outstanding Women in Business tweaks the formula a bit, allowing for a bit more leeway in the roles played in business, offering recognition to people who don’t fit into the traditional CEO or executive director roles. We’re honoring six individuals who have made an impact throughout Maine. Between Women to Watch and Outstanding Women in Business, Mainebiz has honored more than 80 leaders in the past 17 years. Congratulations to each of the 2026 Outstanding Women in Business.
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice
AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.
MedCity FemFwd: Employer Strategies for Women’s Health
In this episode, we’re joined by Cheryl Larson, president and CEO of the Midwest Business Group on Health, for our first in-person recording at MedCity News’ recent Bullseye event.
Watch DeepX CEO on Business Strategy, New Funding
Lokwon Kim, Founder and CEO at DeepX, discusses the chip designer's business strategy and latest funding. He speaks with Shery Ahn on Bloomberg: The Asia Trade.
Discussing the 6th Annual Black Business Expo with AFRO News
AFRO News CEO Dr. Toni Draper joins Jenyne to discuss the 6th Annual Black Business Expo, coinciding with a special anniversary for the paper.
PGA Tour lures another NFL exec to lead media strategy
Brian Rolapp is continuing to bring some of his old NFL colleagues on board at the PGA Tour. Rolapp, the former head of the NFL’s media businesses who took the job of PGA Tour CEO last summer, has made another key hire from the NFL’s executive ranks. According to a report by Josh Carpenter and…
Talk Business & Politics: Arkansas Electric Cooperative Corp. CEO Buddy Hastings, Arkansas Rep. French Hill
Power moves are going on across Arkansas, and across the country.
Omada Health (OMDA) Could Be 4% Undervalued As Record Earnings Reset The Debate
Omada Health (OMDA) drew investor attention on 6 August 2026 after reporting record second quarter results, raising full year 2026 guidance, and outlining a planned CEO transition effective 1 January 2027. See our latest analysis for Omada Health. At a latest share price of $23.67, Omada Health has seen a sharp shift in sentiment, with a 1 day share price return of 21.14% and 7 day share price return of 19.30% around the earnings beat and CEO succession news. That sits within a stronger...
Business Notes: Norfolk shipyard honored; state chamber of commerce names new CEO
View which businesses are celebrating milestones and who is getting accolades.
Warren Buffett is out, and Berkshire Hathaway is spending again
Berkshire Hathaway's famously large pile of cash shrank by about $30 billion last quarter after Greg Abel took over from Warren Buffett as CEO.
'If trust breaks, your business breaks': How Alphonzo Terrell is building Spill to be a different kind of social platform
Spill's CEO explains how Spill puts focus on community, trust, equity, and the future of fandom.
Arena AI CEO says enterprises don't know which AI models to trust
Arena CEO Anastasios Angelopoulos said companies are "terrified" of working with frontier AI companies and China-based open models.
Vigor embraces ‘unfinished business’ as Wolves chase another state championship in 2026
Fueled by the sting of last year's state championship loss, Vigor begins a new chapter in Class 4A with unfinished business and another roster built to compete for a Blue Map.
'Bad rap': Midwest burger giant defies California business doom narrative
Freddy’s Frozen Custard & Steakburgers CEO Chris Dull defends California's business climate, telling Fox News Digital it gets a 'bad rap' while detailing the Midwest burger giant's expansion plans in the Golden State.
Is Beaver’s Mini Mart a small business or ‘Beavermart’ chain?: Here’s what we know
The legal battle between the behemoth Buc-ee’s gas station chain and Beavercreek carryout Beaver’s Mini Mart took a turn this week when Buc-ee’s founder and CEO Arch Aplin III reportedly
Why Take-Two Won’t Share ‘Unprecedented’ ‘Grand Theft Auto VI’ Pre-Order Numbers
CEO Strauss Zelnick says he doesn’t want to mislead shareholders
Rural behavioral health in New Mexico: why the money doesn't become care
A nonprofit healthcare CEO says New Mexico has plenty of money but needs to approach delivering services in rural areas differently.
Take-Two CEO On The Industry Going All Digital: 'Discs Don't Really Make Sense For The Consumer'
Strauss Zelnick thinks his company will still produce some physical games "now and then"
I built Canada’s largest crypto company. But the business climate here made selling to Robinhood inevitable
The CEO of WonderFi says that he sold because Canada's burdensome regulatory climate makes international expansion out of reach.
Uberaba Geopark: A time capsule from the Late Cretaceous period nestled in Brazil's tropical savanna
Uberaba Geopark, also known as the "Land of the Giants," is a region in Brazil's Cerrado biome that preserved thousands of prehistoric fossils.
Burger chain bucks California trend, doubles down on Golden State despite rising costs
Freddy's Frozen Custard & Steakburgers CEO says California gets a "bad rap" as competitors close doors, planning 60 new locations nationwide this year with a Northern California focus.
Kids Empire Brings High-Energy Family Entertainment To Wellington Green - Town-Crier Newspaper
The Mall at Wellington Green recently announced the grand opening of Kids Empire, a vibrant indoor attraction designed to entertain children of all ages through active, imaginative and social play. “Kids Empire is an exciting addition to the Mall at Wellington Green, where families can spend meaningful time together,” said Carmen Spinoso, president and CEO […]
'Bad Rap': Freddy's CEO defends California business climate as rivals retreat
Freddy’s Frozen Custard & Steakburgers CEO Chris Dull defends California's business climate, telling Fox News Digital it gets a 'bad rap' while detailing the Midwest burger giant's expansion plans in the Golden State.
Icons America eyes major expansion that could add hundreds of manufacturing jobs in Gaston County
Scott Lingren, new CEO of Icons America, plans to expand the cosmetics packaging manufacturer's facility in Gaston County and add hundreds of jobs over the next five years.
ADF urges Senate to clarify college sports bill won’t preempt state women’s sports laws
The following quote may be attributed to Alliance Defending Freedom CEO, President, and Chief Counsel Kristen Waggoner regarding the Protect College Sports Act (S. 4668), a bill currently in the U.S. Senate that could be voted on this week: “For nearly a decade, Alliance Defending Freedom has worked with courageous female athletes, state and national […]
Morgridge hosts annual science camp for rural high school students
The Morgridge Institute’s Rural Summer Science Camp allows Wisconsin high school students to experiment in the University of Wisconsin-Madison’s world-class bioscience labs.
‘Warrior Cats’ Video Game Announced Based on Hit Novel Series
Trailmark Games and the Coolabi Group announced “Warrior Cats: Clans of the Forest,” a turn-based RPG inspired by the “Warrior Cats” novel series.
How Aroma-Zone Built A Beauty Business Around Trust Instead Of Trends
Speaking exclusively with Aroma-Zone CEO Sabrina Herloury-Rouget about trust, regional relevance and why beauty needs better guidance, not more hype.
Federal probe of Guggenheim CEO Mark Walter reaches Chicago
Investigators are examining loans involving a little-known Wacker Drive trading firm as part of a broader inquiry into businesses controlled by the Dodgers owner.
‘It will take a few years’: WPP CEO Cindy Rose says outcome-based pay is still years away
British holding company's H1 earnings show signs of improvement in media business despite revenue decline.
Xbox Is Getting Platinum Trophies Later This Year, Says CEO
Xbox is attempting to win back fans, or at least satisfy the ones they already have, by making changes, big and small. Now, Platinum Trophies are coming.
Portillo’s is cutting HQ staff by 18%
“While never an easy decision, it is imperative that we examine areas of the business where we can operate more efficiently and ensure our resources and future investments are directed at the right priorities,” CEO Brett Patterson said in a statement.
This Week in Jacksonville: Business Edition - Cultural Council warns arts funding cuts could ripple beyond City Hall
With Duval County budget season approaching, Cultural Council of Greater Jacksonville CEO Diana Donovan joins host Kent Justice to explain what proposed cuts to arts and culture funding could mean beyond museums and performances—impacting jobs, small businesses, youth programs, and services for veterans and military families.
Paramount CEO David Ellison: The critics are wrong about my politics
Paramount CEO David Ellison: The critics are wrong about my politics. The issue is whether I can be trusted as a steward of CNN.
Former Holy Cross Hospital CEO Kevin Sexton tapped to lead HSCRC
Kevin Sexton, former president and CEO of Holy Cross Health hospitals, has been tapped to chair a powerful state commission charged with setting hospital rates in Maryland, the Moore administration announced Thursday.
Michael Dell’s son built a $13 billion home battery business—and he’s going on 30 years old
Zach Dell is banking on a home electricity and battery rental business that offers backup power without buying an exorbitantly expensive system.
Trump said Qatari jet was destined for his library. That may change
A White House official says no final decision has been made about which plane will go on display at the Trump presidential library. That leaves the fate of the Qatari jet unclear.