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FOR INSIDERS | Whole Hog Politics: A revolutionary reader
[Watch Whole Hog Politics live: Join us today at 9 am EDT at TheHill.com as Chris Stirewalt and host Bill Sammon break down this week’s political news and answer questions from a live online audien…
Browns player dodges question Steelers fans want answered
A Cleveland Browns defender shut down the question Pittsburgh Steelers fans want answered most.
Echoes of Aincrad: Sword Art Online
Bandai Namco has released an 18-minute preview of the feature-length promotional animation Sword Art Online: Unanswered//butterfly included with the Echoes of Aincrad: Sword Art Online Ultimate Edi…
Connections: Sports Edition today: Hints and answers for July 3, 2026, puzzle No. 648
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
Prosser denies conspiring to steal Apple secrets in lawsuit response
After getting a second chance to formally respond to Apple’s lawsuit, Jon Prosser filed his answer today. Here are the details.
Connections: Sports Edition today: Hints and answers for July 2, 2026, puzzle No. 647
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
If we lose our coverage, we lose our lives
By Thomas Buckley My oncologist asked: “Polycythemia Vera. Do you know what that means?” Earlier, I lived in blissful ignorance, unaware I potentially carried a myeloproliferative neoplasm encoded within my DNA. “Yes,” I answered, “A rare form of blood cancer, incurable, not necessarily fatal, provided it’s treated.” At 31, I thought I had life figured […]
Sony will cease production of discs for new PlayStation games in 2028
New games sold for PlayStation consoles will only be available digitally and won’t be sold on discs effective January 2028, Sony has announced. The move applies to all PlayStation games released from that point on, including those made by Sony and those released by third parties. The PlayStation group calls the change “a natural direction for Sony Interactive Entertainment to adapt to consumer trends as the general preference for digital media significantly outpaces physical discs,” according to a PlayStation blog post reviewed by Game File in advance of its publication. As movies, TV and music have shifted from physical media to an age of downloads and streaming, Sony’s move could speed the demise of physical media in a gaming. The industry has offered consumers games via cartridges, cassettes, floppy discs, CDs, DVDs and Blu-Rays across a 50-year stretch. Sony has been reporting to investors in recent years that PlayStation games have been increasingly purchased as downloads, not as discs. The most recent figures show nearly four in five purchases of full games for PlayStation 4 and PlayStation 5 were purchased digitally in the past year. Stats like that may cause today’s news to carry an air of the inevitable. But Sony’s declaration for 2028 is still likely to produce a shock, as the biggest gaming platform on the planet that uses game discs leaves them behind. Discs going away, but the fate of game boxes is unknown Sony is committing to still selling games in physical retailers even after they drop discs in 2028. Just how those games will be sold—in boxes with codes inside, as cards marked with digital redemption codes—is unclear. Digital games will also continue to be sold in the online PlayStation Store. New games released for PlayStation consoles prior to January 2028 will be unaffected by the policy change, Sony says. That means the PS5 games of 2027, be they a new Madden, a new God of War, a new Call of Duty, a new Sly Cooper (one can dream?), would still potentially be offered on disc. PlayStation 6 implications Sony’s timeline for a transition to a no-disc era will also spin up more speculation about the timing and configuration of Sony’s next-generation console, the probable PlayStation 6. “This pretty much guarantees that PS6 won’t arrive until 2028 at the earliest,” Piers Harding-Rolls, senior games research analyst at Ampere Analysis tells Game File. Harding-Rolls also concludes from today’s news that “the base version of a PS6 will not include a physical media drive,” as Sony looks to keep costs down on the device. Sony itself is saying nothing about the PS6 today: not its timing, nor how it might or might not support internal or external disc drives in order to run disc-based PS4 and PS5 games, should the console be backwards compatible. The many signs this was coming Industry support for games being released on physical media has been waning. As has consumer interest in them. PC games effectively went all-digital years ago, thanks to the popularity of playing games through Steam and other digital storefronts. The Covid-19 pandemic and the lockdowns that kept much of the global population home helped shift shopping patterns toward downloads. Sony’s own data shows PlayStation game downloads being an uncommon consumer choice a decade ago and now becoming the norm. On consoles, physical media has been in such decline that Sony and Microsoft both launched their current gen Xbox Series and PS5 consoles in 2020 with cheaper versions that lacked disc drives. In early 2024, Phil Spencer, then head of Xbox, told me that ““[w]e ship games physically and digitally, and we’re really just following what the customers are doing.” He added that the game industry had become an outlier in still supporting disc-based entertainment, even as movies and TV have bailed on discs in favor of downloads and steaming: “Gaming consoles themselves have kind of become the last consumer electronic device that has a drive. And this is a real issue, just in terms of the number of manufacturers that are actually building drives and the cost associated with those. And when you think about cogs that we’re going to go put in a console—and as you have fewer suppliers and fewer buyers—the cost of the drive does have an impact.” Last year, the Nintendo’s Switch 2, which uses cartridges rather than discs, introduced the concept of game-key cards, which are physical media that contain no game, just a prompt for a download. Even disc-based games aren’t what they once were, now frequently containing just stubs of games rather than the whole thing. The website Does It Play has tested over 3000 games and found that, for example, that the disc version of this year’s hit 007: First Light, only contained the game’s first mission, with the rest needing to be downloaded. Beyond all that, last week brought the news that Grand Theft Auto VI, likely the biggest game launch this decade, will debut for PS5 and Xbox Series without a disc-based version. Today’s big news comes to you for free. Game File is a reader-supported publication. To receive new posts and ensure more of my work is possible, please consider becoming a free or paid subscriber. Subscribe Discs helped define PlayStation However the trends in entertainment may be going, it is still remarkable to see PlayStation ditch discs given their importance in PlayStation history: In the late 1990s, the first PlayStation’s support for games on relatively cheap CD-ROMs instead of traditional game cartridges allowed the upstart console to outmaneuver cartridge-based systems from Nintendo and Sega, as it drove down game prices down in the process. (The cheaper disc format even prompted Final Fantasy VII maker Square to taunt Nintendo in a magazine ad, saying that if the game was “available on cartridge, it’d retail for around $1200.”) PlayStation devices often doubled as machines for watching movies and TV on the latest disc-based formats. In the late 2000s, for example, Sony’s pricy PS3 gained traction as a go-to device for playing then-novel Blu-Ray discs. In 2013, Sony effectively roasted the digital game-sharing restrictions proposed by rival Microsoft for its upcoming Xbox One console by showing how games could be shared for the then-upcoming PS4. In a 21-second clip that has over 20 million views on YouTube, one PlayStation executive simply handed a game box—presumably with disc inside—to another, who said “thanks.” Sony’s possible motivations The PlayStation announcement today cites “consumer preferences” and a shift away from discs among “the broader entertainment industry,” but does not delve into the decision-making process that brought Sony to this point. Sony is not discussing the economics of this move (I asked!), but there are a number of potential factors: Abandoning discs will spare Sony the cost of manufacturing and shipping them, which analysts and industry veterans I spoke to said could account for $1 or so of a game’s retail price. For first-party games, that’s direct savings for Sony, though the amount is limited by the winnowing percentage of people who were even buying the disc-based versions. For third-party games, Sony could pass the savings on to partners or just retain the better profit margin for themselves. As the 2024 comments from Phil Spencer alluded to, leaving discs behind could mean leaving disc-drives behind, allowing Sony to produce consoles more cheaply. Switching to digital-only for games could diminish the risks of copies of new games leaking. It would also seemingly make second-hand sales of used games impossible, pushing more people to buy their own copies of games. These economic benefits for Sony could be boons for the games industry overall, Ampere analyst Piers Harding-Rolls tells Game File. Among other things, it could free publishers and retailers from having to worry about securing an inventory of game discs when trying to sell games, he noted. “If there is a way to streamline the business of games retail, I generally think it’s a good thing for the industry as it removes unnecessary costs,” Harding-Rolls said. “This will help offset pressure on margins from other directions – development and staffing costs for example.” Should the industry shift from game boxes that contain discs to smaller, cheaper game cards, Harding-Rolls said, that reduces pressure on publishers and retailers. “The advantage of everything going digital for the industry is that sales can be tracked much more easily and there is less commercial risk for publishers wanting to continue selling via retail,” he said. The shift to no discs will also likely impact game development timelines, as developers will no longer face the same urgency to have a build ready to submit to PlayStation for the production of a disc, as industry experts noted around GTA VI’s no-disc news last week. Instead, projects may gain weeks of development time, in the event delivery deadlines for platform approval move closer to release date. Preservationists’ likely worries While millions of gamers have shifted to digital, there are still people who associate game discs—and only game discs—with actual ownership of PlayStation games. That portion of the gaming community spoke up last week about wanting to buy a version of GTA VI that they could hold in their hands, could lend to a friend and could potentially pop into a well-preserved PS5 console three decades from now and still see it run. Such gamers didn’t want to worry that they’d merely purchased a digital copy that could lose access to the game if, say, the company behind the game someday turns of the servers that transmit downloadable copies. Digital copies of games are inherently less long-lasting, because consumers aren’t actually buying a game (on a disc), just buying access to the game. The fine print in online gaming shops notes this, as does a recent law that went on the books in California in 2025. That lasw requires game publishers doing business in the state to refrain from words like “sell” when offering digital copies of games, unless they explicitly tell consumers that what’s being sold isn’t the game itself but a potentially revocable license to access it. A Sony spokesperson noted to Game File that “[w]ith all digital content, including games, movies, and music, players are purchasing a personal license for non-commercial use.” Regarding the fears of PlayStation games being lost to time in an all-digital era, the rep also noted that Sony remains “committed to delivering experiences from past generations to the new platforms our players are using.” They noted that PlayStation has used emulation and remasters to keep offering its classic games to modern gamers. It’s true that many consumers have become accustomed to not having physical copies of new music albums or movies, but the relative precariousness of digital copies of games is in fact being highlighted today by…. Sony’s other big announcement: the upcoming closure of the PS3 and PS Vita online stores Sony said today that it will be closing the online marketplaces for its PlayStation 3 console and PS Vita handheld in most countries in July 2027 (sooner elsewhere: August 2026 for the PS3 store Mexico, Honduras and Nicaragua; late 2026 for PS3 in other Latin American countries and the Middle East). “We know this news may be disappointing to PS3 and PS Vita players who hold a special place in their hearts for this generation of gaming,” Sony said in its announcement, saying the move “was not an easy decision for us to make.” Sony said that PS3 and Vita marketplaces “are no longer able” to support modern commerce systems, prompting a “need” to close the shops and focus on more modern PlayStation platform stores. The news may spark some deja vu. Sony announced back in March 2021 that it planned to take the PS3, Vita and PlayStation Portable marketplaces offline that summer. The move would have caused some 2,000 digital-only games to become unavailable for new purchasers, according to a VGC analysis at the time. Fans complained loudly. By April 2021, Sony walked back the PS3 and Vita shop closures, with then PlayStation boss Jim Ryan saying “it’s clear that we made the wrong decision here.” This time around, Sony is giving a longer notice period in most regions. The closure of those stores is still likely to cut off access to new purchases of digital-only PS3 and Vita games. The current PlayStation 5 marketplace sells PS5 and PS4 games, as well as a selection of PS1 and PS2 games. It does not sell PS3 games, because games for that platform can’t run on the system (some are offered via a PlayStation Plus streaming option). Vita games also aren’t sold via PS5. Sony says digitally purchased PS3 and Vita games will be downloadable after the stores’ shutdowns “for the foreseeable future.” Sony’s move contrasts with Microsoft’s Xbox platform, which continues to sell and support games from all four Xbox console generations. But it puts it in line with Nintendo, which disabled purchases in the marketplace for its Wii console (a contemporary of the PS3) in 2019. Nintendo discontinued purchases in the online shop for its 3DS portable (a contemporary of the Vita) in 2023. The big questions about Sony’s 2028 post-disc era Will Microsoft follow suit, ending support for new disc-based games on Xbox platforms and therefore all game consoles, too? Whether Microsoft does or not, will third-parties that can no longer release games on discs for PlayStation, simply ditch the disc options across the board? Given the GTA VI no-disc experiment launching this November, will more game publishers decide to forgo disc-based offerings even in 2027? How will no-disc PS5/6 games be packaged and sold in brick-and-mortar retail stores? What becomes of game sharing in an all-digital era? Will Sony modify its current set-up, which currently allows some sharing of digital games across a pair of consoles, to allow more casual lending? (See for example, Nintendo’s year-old system of letting players lend a digital game to another player in a “family group” for up to 14 days.) Will there be a version of a PS6 with a disc drive? Or will a drive be offered as an add-on? And how will gamers who want to retain access to PS4/PS5 disc-based games react to whichever configurations Sony chooses to offer? What will the final disc-based PlayStation game be?
10 questions the Steelers must answer at training camp
When the Steelers get together for training camp, here are the 10 questions they have to answer.
Connections: Sports Edition today: Hints and answers for July 1, 2026, puzzle No. 646
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
Sewerage and Water Board meet with Decatur businesses to answer questions about project completion
The floor was open for questions at Turtle Bay, where owners and employees pressed SWBNO about when the barricades will come down.
Wilmington Small Business Coalition: Building Momentum in 2026 by Heather McWhorter
This article was contributed by Lydia Thomas, UNCW CIE Program Manager. North Carolina continues to be one of the best states to start a business and in 2025, Wilmington, North Carolina earned a spot on the GoDaddy list of the top 10 most entrepreneurial cities in the U.S. While many know Wilmington as small beach town with exceptional food, lots of coffee shops, and fun, vibrant summer activities, a closer look reveals a thriving innovation economy. You’ll find startups emerging across industries including software, healthtech, bluetech, and fintech. At the core of this entrepreneurial ecosystem is the Wilmington Small Business Coalition, with small business advocates and entrepreneur support organizations (ESOs) dedicated to helping founders grow, thrive, and succeed. “No Wrong Door” Established in 2016, the Coalition was designed to make it easier for individuals and small businesses to access resources most suited to their particular needs. The Coalition is designed to have a “no wrong door” entryway into the regional startup ecosystem. Whether you are exploring a new idea sketched on the back of a napkin or leading a more established, growth-stage company, Coalition members can help connect you with the programs, funding opportunities, mentors, and resources best suited to your needs. No matter where you are in your entrepreneurial journey, any Coalition organization can help point you in the right direction. Coalition Members and Leadership Coalition members include the UNCW Center for Innovation and Entrepreneurship (UNCW CIE), AARP, Brunswick Community College Small Business Center, Cape Fear Community College Small Business Center, Cape Fear Region SCORE, Genesis Block Foundation, Network for Entrepreneurs in Wilmington (NEW), Small Business & Technology Development Center (SBTDC), Greater Wilmington Chamber of Commerce, YWCA Living the Dream Center for Entrepreneurship, Carolina Community Impact Fund (CCI Fund), Partner Community Capital, 717mkt Office Collaborative, NC Biotech, and Institute NC. In May 2026, the Coalition held its leadership elections, resulting in the selection of a new executive team. The following officers were elected to serve two-year terms: Chair: Lydia Thomas, UNCW CIE Vice Chair: Diane Lantz, CCI Fund Secretary: Aariene Hansley, Genesis Block Foundation Treasurer: Gloria Monroe, SBTDC Vision for the Wilmington Small Business Coalition In 2026, the Wilmington Small Business Coalition continues its work as a collaborative network of organizations. By connecting programs, expertise, and services across partner organizations, entrepreneurs can more easily find the right support at the right time. Rather than operating in silos, the Coalition aims to function as a unified, cohesive system of support for small businesses and entrepreneurs, ensuring that resources and expertise across partner organizations are visible and accessible. Through stronger collaboration and shared pathways, entrepreneurs can move more seamlessly from idea to startup to growth. Looking to dive into the Wilmington entrepreneurial ecosystem? Connect with any of the Coalition partners to get started! Connect with CIE To learn more about CIE and our services, programs, and events, join the CIE newsletter. You can also follow us on social media: Instagram, Facebook, LinkedIn, TikTok, or YouTube. CIE’s website is uncw.edu/cie. Heather McWhorter is the director of the UNCW Center for Innovation and Entrepreneurship (CIE). CIE supports innovation-forward start-ups and helps to build a vibrant innovation economy for all in southeast NC.
Today's NYT Connections: Sports Edition Hints, Answers for July 1 #646
Here's today's Connections: Sports Edition answer and hints for groups. These clues will help you solve The New York Times' popular puzzle game, Connections: Sports Edition, every day.
Insurgent progressives and veteran incumbents compete for Colorado Democrats' votes
Colorado’s Democratic primaries on Tuesday will help answer a question the party has increasingly faced nationally: Are voters gravitating toward a younger, more progressive generation of leaders or sticking with established veterans?
Curiously Colored Elephant Seal Causes A Stir In California State Park: Why Is It Purple?
What makes a seal turn purple? We actually have an answer.
Connections: Sports Edition today: Hints and answers for June 30, 2026, puzzle No. 645
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
NYT Crossword Answers for June 30, 2026
John Liber makes his New York Times Crossword debut.
Careers That Shaped Biology
Every great scientific career begins with a question no one has been able to answer — and a scientist stubborn enough to keep asking it. This series looks back at the careers of some of HHMI’s most distinguished scientists — people whose contributions have changed what we know about life itself, and whose stories reflect the best of what science, and scientists, can be.
Growing scientific evidence links e-cigarette chemicals to heart health risks
DALLAS, June 29, 2026 — Is vaping bad for my health? As people who use e-cigarettes and their loved ones pose questions like this, growing scientific evidence shows that the answer is yes. Research studies show that several chemicals found in...
Mayo Clinic Q&A: Watch out for summer sports injuries in youth and adult athletes
DEAR MAYO CLINIC: Our teenagers are both student athletes and active in their sports year-round. I'm concerned about injuries that could sideline them. What should we watch for? ANSWER: As the school year ends, summer sports heat up for students and adults alike. Summer may be a prime season for a sport, such as baseball […]
After months of unanswered pain, a Philly woman learned she had Stage 3 colon cancer. Now she’s pushing for equitable care
Medical advances mean that more people are surviving cancer. But not everyone is benefiting from those gains equally, a new report shows.
Connections: Sports Edition today: Hints and answers for June 29, 2026, puzzle No. 644
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
Theater Quiz for June 2026: Pride, Politics and Prizes
How well were you paying attention to the theater over the past month? Answer these ten questions, and a whopper of a bonus question about Tony acceptance speeches, to find out.
Sony’s New Blu-ray & DVD Player Upscales DVDs to Near-HD Quality - Bring Your Old DVDs To Life Again
In a time when streaming services continue to raise prices, fragment content libraries, remove content, and push intrusive ads, many households are rediscovering the reliability and ownership of physical DVDs and Blu-rays. Sony has answered this shift with the release of its latest affordable disc player: the Sony BDP-S1700U. Priced at just $114.99, this sleek […]
Peer Support May Be the Answer to the Mental Health Crisis
Peer support is the sleeping giant that may help us overcome the social and mental health crises we currently face.
Connections: Sports Edition today: Hints and answers for June 28, 2026, puzzle No. 643
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
Today's NYT Connections: Sports Edition Hints, Answers for June 28 #643
Here's today's Connections: Sports Edition answer and hints for groups. These clues will help you solve The New York Times' popular puzzle game, Connections: Sports Edition, every day.
Scientists finally explain why these wild boars stay more radioactive than Chernobyl's wolves - Futura-Sciences
What explains this surprising finding? The answer appears to be a complex mix of history, ecology, and diet. Bavaria’s wild boars mainly feed on underground fungi that absorbed radioactive fallout from both the notorious Chernobyl disaster and Cold War-era nuclear testing. Unlike wolves, which sit higher on the food chain...
Which coach helped Dianna Russini get out of a ticket?
The recent New York Times article regarding former New York Times reporter Dianna Russini answered some lingering questions.
Connections: Sports Edition today: Hints and answers for June 27, 2026, puzzle No. 642
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
Congress subpoenas Leon Black during interview about Jeffrey Epstein
The House Oversight Committee issued subpoenas to billionaire Leon Black after he declined to answer questions about non-disclosure agreements.
Why Your Nighttime Dreams Are So Weird—Science Finally Has the Answer - Futura-Sciences
The Secret Life of Dreams: Not Just Random Nonsense Remember the dream you had last night? Maybe you’re left with just a trace—a sweet feeling, maybe, or a strange discomfort. But there’s rarely a story you could actually retell. Because, in the end, a dream is a deeply personal experience....
Why Do Deadly Viruses Spare Mosquitoes? Science Has an Answer
Mosquitoes carry some of the world's deadliest viruses, biting victim after victim for their entire lives without ever getting sick themselves. Scientists have long suspected a biological explanation,...
Whole Hog Politics: It was voters, not Senate Republicans, who forced Trump’s hand on Iran
[Watch Whole Hog Politics live: Join us today at 9 am ET at TheHill.com as Chris Stirewalt and host Bill Sammon break down this week’s political news and answer questions from a live online audienc…
'The Vampire Lestat's Sam Reid on Magnus, Claudia, Sofia, and more
Would Lestat listen to Chappell Roan? Asked and answered.
Connections: Sports Edition today: Hints and answers for June 26, 2026, puzzle No. 641
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Huge Prime Day Discounts on Gaming Laptops and Desktops from Lenovo, MSI, and More
Not getting enough power from your gaming PC? We've got the answer courtesy of these dozen discounted laptops and desktops during Prime Day.
Connections: Sports Edition today: Hints and answers for June 25, 2026, puzzle No. 640
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Former MLB GM Shares Answer To Yankees' Bullpen Woes
The New York Yankees have a clear need in the bullpen, but the team may not have to acquire one through a trade. New York addressed its bullpen at last year's trade deadline, acquiring the likes of David Bednar and Camilo Doval among other relievers. However, Doval has struggled this season, so the ...
The biotech founder asking why good science gets stuck
As an undergraduate, Alinta Furnell led student societies, pitched startup ideas and built biotechnology ventures. Now, the UNSW alumna is investigating one of innovation’s biggest challenges – why so many scientific breakthroughs never make it beyond the lab.
Families, business owners push leadership to break silence following Haywood Mall shooting
Eleven days after shots rang out at Haywood Mall in Greenville, families and business owners are growing frustrated by the lack of answers from Simon Corporate and Upstate-based mall management.
This startup is using AI to close gaps in women’s healthcare
Xella Health’s precision health platform combines biomarker testing, clinical guidance, and AI analysis to help women get earlier answers about hard-to-diagnose conditions.
Connections: Sports Edition today: Hints and answers for June 24, 2026, puzzle No. 639
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Do the Utah Jazz have concerns about Darryn Peterson’s health? Here’s what Austin Ainge said.
Darryn Peterson faced a lot of questions this year. The Utah Jazz are satisfied with his answers. Here's why.
Yankees even series, Malgeri gets two hits in debut
A slim lead couldn’t hold up and the Tigers’ bats couldn’t answer with quite enough.
Family says SoCal police fatally shot teen during mental health crisis
Family files a claim against the city of Santa Ana, saying police fatally shot teen during mental health crisis without using non-lethal alternatives
Lawmakers call for answers from Wyoming Business Council leader
After slashing the agency's budget, legislators examine the state's role in economic development.
Justice Department and New York swap suits over state's mask ban
State leaders answered by filing a lawsuit to block the Justice Department's efforts.
Dogs or cats: which is actually smarter, according to science - Futura-Sciences
It is one of the oldest arguments between pet owners, and it usually generates more heat than light. So what happens when you ask science instead of your group chat? The honest answer is that “smarter” is a slippery word, but researchers do have one hard number that tilts the...
NYT Mini crossword answers, hints for June 23, 2026
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Connections: Sports Edition today: Hints and answers for June 23, 2026, puzzle No. 638
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Will Arnett refuses to answer Jason Bateman’s question about Amy Poehler: 'Are you looking for clicks?'
Will Arnett is gobsmacked by what his cohost Jason Bateman wanted to know about his ex-wife, Amy Poehler.
Scientists stumped by bird that “shouldn’t exist”—rare discovery shocks experts - Futura-Sciences
A Bird That Defies the Rulebook In a typically peaceful backyard in Texas, birdwatchers were caught off guard when an unfamiliar bird swooped onto the scene. It baffled observers: clearly neither a typical blue jay nor a full-fledged green jay. What was it? The answer would turn out to be...
RedMagic reveals new Lenovo Legion Tab Gen 5 rival with OLED display
The RedMagic Gaming Tablet 5 Pro has been revealed, and it's the company's answer to the Lenovo Legion Tab Gen 5. This Snapdragon 8 Elite Gen 5 pad with OLED display is set to launch in China on June 30, 2026.
Connections: Sports Edition today: Hints and answers for June 22, 2026, puzzle No. 637
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Today's NYT Connections: Sports Edition Hints, Answers for June 22 #637
Here's today's Connections: Sports Edition answer and hints for groups. These clues will help you solve The New York Times' popular puzzle game, Connections: Sports Edition, every day.
Eagles offensive line questions that must be answered in camp
The Eagles enter training camp with offensive line questions tied to Lane Johnson’s health, Cam Jurgens and Landon Dickerson’s rebound seasons, Tyler Steen’s growth, and Jordan Mailata’s dominance
High-Speed Rail CEO Ian Choudri on transparency, project's path moving forward
California High-Speed Rail CEO Ian Choudri is answering questions for the first time since he was put on administrative leave.
Growing Interest in Liver Wellness Leads Consumers to Explore PureHealth Research Liver Health Supplements
What does it actually mean to feel "off" after a heavy meal, a few too many late nights, or a season of indulgence? More often than not, the answer points back to the liver – and PureHealth Research is spotlighting growing consumer interest in liver wellness, highlighting how targeted nutritional support could play a role in maintaining healthy liver function and overall well-being.
Probe into Newsom produces a lot of smoke. Is there any fire?
Some say the investigation will boost the governor's presidential prospects. But it’s too soon to say. The action by Trump's corrupted Department of "Justice" presents more questions than answers.
NYT Mini crossword answers, hints for June 21, 2026
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Connections: Sports Edition today: Hints and answers for June 21, 2026, puzzle No. 636
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I Finally Realized How I Know 'Sweet Magnolias' Star Brooke Elliott & It Hit Me Like a Truck
I finally realized where I knew Sweet Magnolias star Brooke Elliott from, and the answer unlocked a whole TV memory. Here's the iconic role I completely forgot about.
NYT Pips hints, answers for June 20, 2026
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NYT Mini crossword answers, hints for June 20, 2026
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Dalton Rushing flushes a nightmare night, delivers walk-off moment
LOS ANGELES — Dalton Rushing spent most of Friday night searching for answers.
Connections: Sports Edition today: Hints and answers for June 20, 2026, puzzle No. 635
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White House Creates a UAP Science Council
Below is a transcript of an interview I just had with Elizabeth Vargas on NewsNation. Her questions are labeled below by EV and my answers…
Congressman demands answers from Bard College about ties to Jeffrey Epstein
A Democrat on the House Judiciary Committee requested records from the college about its president's connections to the convicted sex offender.
After Local Drag Queen and Business Owner Banned From Instagram, More Questions Than Answers
Club ERA owner Naomi Dix says that her accounts were shut down this week for purportedly violating community standards.
Student research in Yellowstone could help scientists understand life on other planets
Arizona State University doctoral candidates Tanner Barnes and Vince Debes both enjoy a good hike. But when they set out on trails in places like Yellowstone National Park, they are not just taking in the sights — they are collecting samples that could answer some of science’s biggest questions: how life survives in extreme environments, how planets become habitable and what signs of life scientists should look for beyond Earth.
Researchers found a Wordle strategy that wins 99% of the time
Researchers developed a Wordle-solving strategy that succeeds 99% of the time by focusing on information gain rather than likely answers. The method uses Shannon entropy to identify guesses that reveal the most about the hidden word. Each guess is designed to slash uncertainty and narrow the possibilities faster. The result significantly outperformed more traditional Wordle tactics.
Your Business Should Hire an AI Receptionist. Here’s How Quickly They Can Pay for Themselves
AI receptionists can catch missed bookings, answer questions, and free up employees to focus on customers.
Whole Hog Politics: Trump proves hard to follow for GOP
[Watch “Whole Hog Politics” live: Join us today at 9 a.m. EDT at TheHill.com as Chris Stirewalt and host Bill Sammon break down this week’s political news and answer questions from a li…
#PostPulpit mailbag: What will happen at tight end?
The latest edition of our Patriots mailbag answers questions about the tight end position, Gabe Jacas, and more.
Connections: Sports Edition today: Hints and answers for June 19, 2026, puzzle No. 634
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RWJBarnabas Health Invests $1.5 Million to Support Local Community Health Initiatives in New Brunswick, Middlesex County
RWJBarnabas Health today announced a combined $1.5 million investment to support local organizations working to address barriers to care, food insecurity and economic stability among underserved communities in New Brunswick and Middlesex County.
Health kicks off Aspen Ideas June 22-25
Since 2014, Aspen Ideas: Health has preceded the Aspen Ideas festivals. This year, from June 22-25, it offers more than 60 sessions with seven program tracks revolving around patient care, new treatments and technology, longevity and vitality, creativity, medical enterprise, leadership and how health-related questions often lack black or white answers.
3 Burning Questions for the Rams Ahead of Training Camp
With training camp set to take place in July, here are three burning questions to be answered for the Los Angeles Rams.
Mayo Clinic Q&A: Block some time out for health screenings
DEAR MAYO CLINIC: Since I turned 40, my clinic has been sending me a slew of reminders about men's health screenings. Are they really necessary? ANSWER: Yes! Blocking out some time for these important health screenings is one of the most important things you can do for yourself. Historically, men have been hesitant to seek […]
Looking for answers
Phillies starting pitcher Andrew Painter is heading back to triple A.
Could Jon Ossoff be Democrats' 2028 answer? He must pass a 2026 test
The Georgia senator is a 2028 Democratic prospect, but first he must win re-election in a swing state that went for Trump.
Connections: Sports Edition today: Hints and answers for June 18, 2026, puzzle No. 633
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Cramer's lightning round: Buy Vistra
"Mad Money" host Jim Cramer rings the lightning round bell, which means he's giving his answers to callers' stock questions at rapid speed.
iPadOS 27 Hands-On: Everything New for iPad
Like iOS 27, iPadOS 27 gains a smarter, more capable version of Siri, the Siri app, and new Apple Intelligence features in apps, but there are a few iPad-only standouts. Subscribe to the MacRumors YouTube channel for more videos. Siri AI on iPad has all of the same features as Siri AI on the iPhone, so it can access your personal data, search the web for answers, complete tasks in apps, and answer questions about what's on your screen.
When Health Results Raise Questions but Provide Few Answers
Older people are often treated as if their judgment is less valuable, creating the risk of a future where human intelligence is seen as something that depreciates with age.
KFF Tracking Poll on Health Information and Trust: Use of Social Media and AI For Health Information and Advice
This poll finds that about 3 in 10 adults turn to social media for health information and advice at least monthly. Community connection and the need for immediate answers are the top reasons why people are turning to these tools. Slim majorities of those who use social media for health are confident they can tell what is true, and relatively few take steps to check the information they receive.
NYT Mini crossword answers, hints for June 17, 2026
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US senator demands answers from commish Rob Manfred after MLB's warning to Giants players who wrote Bible verses on Pride Night caps
Connections: Sports Edition today: Hints and answers for June 17, 2026, puzzle No. 632
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Latvia pilots citizen engagement in research grant evaluations
Latvia has introduced an element of citizen engagement to the evaluation of nationally funded research grants. The aim is to both create more connections between science and society, and to improve the quality of its evaluations. The move comes as research funders across Europe are experimenting with ways to improve evaluation processes in the face of a sharpened focus on science’s impact on society. Evaluators of grant applications submitted to Latvia’s Fundamental and Applied Research Programme (FLPP), the country’s main research funder, will this year have the option of consulting citizen feedback on challenges the public thinks science should focus on to inform their decisions. “In recent years, both public discussions and policy-level debates in Latvia have highlighted the importance of demonstrating how publicly funded research contributes to society, the economy and the resolution of real-world challenges,” said a source at the Latvian Council of Science (LCS), which manages the FLPP. “At the same time, research institutions themselves expressed interest in improving the project evaluation framework while continuing to ensure that funding is awarded to the highest-quality projects,” the source added. The citizen input comes from a survey that was conducted between 25 February and 16 March 2025, to which 1,737 people responded. It gathered information on what the public views as problem areas for Latvia, and the role of science and technology in providing solutions to these problems. A summary of these responses has been included as an annex to the FLPP 2026 call for proposals that evaluators can refer to, purely in an advisory manner, when judging proposals. Results from the survey show that the main problem areas identified by the public were in healthcare and public health, followed by the development of new treatment methods and medicines, and then digital technology, data security and cyber security. At the bottom of the list was research aimed at acquiring new knowledge about the universe, matter and the laws of nature. Further analysis looked at the public view of the possible role of science in solving these problems. The survey charted 4,167 individual responses based on open-ended questions that were derived from the participants’ answers. The analysis again found that medical and health sciences topped the scoring, with 788 responses referring to the field. Humanities and the arts were bottom of the list, with 625. Digging further into the details, the survey suggests citizens are aware of and concerned about a number of research areas. This includes technologies and innovation to improve the environment or reduce pollution, the development of modern military technologies and cybersecurity tools, and the development and application of artificial intelligence, among others. “We hope this initiative will help strengthen public trust in science and create a more meaningful dialogue between researchers and society,” the LCS source said, adding that it offers benefits to researchers, evaluators and to the general public. More space for citizen engagement in evaluationsThere is a gradual but increasing use of citizen engagement in research evaluation processes around Europe, especially in healthcare, but it remains relatively rare, said Henry Sauermann, a professor at the European School of Management and Technology in Berlin and an expert in citizen science.“Given that we are at a point where citizen involvement is extremely limited, there is presumably space for more, but it's not that we should do it just because we want to do it,” he told Science|Business. He said some research lends itself better to having citizen input, and this usually tends to be on the applied end of the science spectrum where the public can offer useful feedback based on their experiences. He added that advising scientists on certain topics to study is also a useful approach, in the way that Latvia is doing. “The public does fund a lot of science, there's a lot of tax money going into this. We of course do want to preserve academic freedom, but it's also not unreasonable to incorporate more feedback or input from citizens where possible,” he said. Related articlesCitizen science: where, when, and how to let the public contribute to researchHow can Europe cope with a flood of AI-assisted research grant proposals?Data Corner: Horizon Europe’s AI, digital and data call success rate is 5.2%There are several ways of involving citizens in science funding. The most minimal way is having a few representatives on a panel, such as members of a patient group or union. The most direct way is crowdsourcing funding for specific projects. There is an increasing number of online platforms that allow the public to chip in to support scientific proposals.Sauermann studied this in a recent paper and found that it can have its uses, but it still is not clear if there are benefits to it. There are various assumptions linked to citizen engagement, for example that it increases public trust in science, or that it provides a representative view of what the public thinks about science. These are not necessarily true, Sauermann found. People who participate in engagement activities tend to already be very trusting of science, and, on the whole, it is generally the well-off and well educated who contribute, giving a narrow view of public opinion. On whether citizen input can help manage the increasing number of proposals that are being submitted due to assistance from AI, Sauermann is more sceptical. “The obvious answer to the flood of AI-written proposals is AI-driven evaluation,” he said, adding that it doesn’t mean citizen engagement shouldn’t be a part of evaluations in a well thought-out manner. Southern Denmark’s successful approachOne successful example of citizen engagement in science evaluations was implemented in southern Denmark. Between 2019 and 2025, citizens in the region were invited to vote to fund one of five pre-selected projects in the field of healthcare. The project, called A Healthier Southern Denmark, was a collaboration between regional authorities, the University of Southern Denmark, and two media partners. Over the seven years, there were 75,000 votes and significant public engagement online and on social media. “It was a bit of a wild project, we’d never done something like that before and we were a bit nervous about what would be said in the media about it. But actually, people were very positive,” said Anne Kathrine Overgaard, one of the main organisers of the project from the University of Southern Denmark. The university and its researchers have learned a lot from the experience, particularly about engaging with society and shaping their research to match real-world needs. This is important with Europe’s increasing focus on competitiveness and bringing innovations to market faster, Overgaard said. She hopes to see more citizen engagement in evaluation processes and in science more broadly. “For many years, citizen engagement has been a bit of an add-on to proposals, just to check a box. But I think things are changing,” she said. It’s less about citizens just gathering data and more “about the dialogue between the public and the scientists,” she said. The initiative ended last year as the team wanted to regroup to find fresh momentum. The development of AI and AI-written proposals has made Overgaard reflect on how the project could be reworked to help evaluators. She hopes to bring it back in the future. “It could be a good idea to try this initiative again in a slightly re-worked format,” she said.
Connections: Sports Edition today: Hints and answers for June 16, 2026, puzzle No. 631
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A vague Iran deal leaves more questions than answers
Trump hailed the document as a breakthrough after months of negotiations. Yet its broad contours remained unclear over a day after the deal was announced.
RFK Jr under fire for ‘bullying’ letter to scientific journal
Health advocates criticized Kennedy’s move demanding answers from journal that removed ‘flawed’ vaccine study
MSU professor reflects on the ‘pursuit of happiness’ 250 years since America’s inception
Raul Rodriguez, professor and director of MSU's LeFrak Forum forum, answers questions on what the “pursuit of happiness” means two-and-a-half centuries later.