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Why Kayshon Boutte could be immediately fantasy football relevant
Boutte will be making plays alongside Nico Collins
Not hitting your step goal? Pick up the pace
Walking at a brisker pace may lower the risk of early death, even for people who don’t reach high daily step counts, a new study found. Here’s what experts recommend.
Why Brandon Marsh's slump will derail Phillies' NL East chances
The Philadelphia Phillies are looking to surpass the Atlanta Braves in the National League East standings. They will need players to step up over the next few weeks amid their pursuit of winning the division. Of course, Philadelphia is hoping its stars can lead the way. Starting pitching is a strength for this Phillies ball club. Zack Wheeler has […] The post Why Brandon Marsh's slump will derail Phillies' NL East chances appeared first on ClutchPoints.
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Lancaster County judge dismisses challenge to Nebraska K-12, collegiate sports ballot measure
A judge dismissed all objections to a ballot measure seeking to place sex-separate school sports requirements in the Nebraska Constitution.
Shohei Ohtani’s Health Raises New Alarm After One-Game Dodgers Return
Los Angeles Dodgers star Shohei Ohtani is out of the lineup just one day after returning, sparking increased alarm.
Cardinal Health (CAH) Declines More Than Market: Some Information for Investors
In the latest trading session, Cardinal Health (CAH) closed at $240.49, marking a -2.71% move from the previous day.
Reflecting on Josh Allen’s career to date against the Texans
Houston has not been kind to Josh Allen
AMC will pay $120 million to settle 'Walking Dead' profits lawsuit
LOS ANGELES — AMC Global Media, the network behind the storied zombie franchise "The Walking Dead," has settled a yearslong profits lawsuit from the show's creator and producers. The New
Starbucks raises health insurance premiums, sparking worker tension
Rising costs for health insurance premiums offered to Starbucks workers are sparking tension.
LG TV shown capable of tracking user activity, even when offline
“It doesn’t cost a lot to store text forever.”...
Smithfield Foods expects to swing to third-quarter operating loss in fresh pork business
Smithfield Foods said on Tuesday its fresh pork segment is expected to swing to an adjusted operating loss in the third quarter, due to persistent pressure from lower hog prices and a shrinking industry market spread amid cautious spending.
Three-time MVP Aaron Judge returns to Yankees
BRONX, N.Y. (WIVT/WBGH) – Sticking with the diamond, let’s move up to the major leagues where the Yankees are set to welcome back the captain tonight. Aaron Judge is making his return in the pinstripes tonight. No. 99 ironically had a 99-day absence after he suffered a broken rib. The three-time AL MVP missed 84 […]
Supreme Court rejects Missouri’s request to use congressional map with extra GOP seat
The Supreme Court on Tuesday denied Missouri’s request to use a congressional map for the November midterm election that would have given Republicans a chance to flip a seat, a rare setback for the GOP’s effort to keep control of the House next year by eking out an advantage from its political boundaries.
Fashion, food and fun combine to make this event a success
arc THRIFT STORES Denver News: “Let’s Celebrate” was the theme for arc Thrift Stores’ annual fundraiser, and it’s not a stretch to say that’s exactly what everyone did at this Sept. 3 gathering held at Denver Botanic Gardens. The crowd that filled the gigantic tent overlooking the UMB Amphitheater launched the celebration with a social hour where good conversations, along […]
Unlocking Forest Diversity from Above: Fieldwork at Smithsonian’s BiodiversiTREE
Laying groundwork for using airborne remote sensing to better understand the characteristics of forest species diversity.
Blackstone explores sale of ZO Skin Health, sources say
Investment firm Blackstone is looking to sell medical-grade skincare company ZO Skin Health, which could be valued at around $2 billion in any deal, according to people familiar with the matter.
Gemini app makes Daily Brief free in the US
After introducing at I/O 2026 in May, Google is making Daily Brief in the Gemini app available for free in the US.
Fact-checking Trump's stories about his own 9/11 response
President Donald Trump recounted his response to the Sept. 11, 2001, attacks in an interview and event leading up to the 25th anniversary this week, repeating statements that lack evidence about aiding in the recovery.
Ohio politicians keep promise to rebuke Les Wexner by donating $200K in campaign contributions
Freedom a la Cart, a downtown Columbus cafe that employs sex trafficking survivors, was one of several organizations that politicians donated to this year.
Senate Set to Vote to Begin Debate on Protect College Sports Act
Background The Protect College Sports Act of 2026 (PCSA), introduced in the Senate on June 2, 2026, by Senators Ted Cruz (R-TX) and Maria Cantwell (D-WA) and joined by Senators Eric Schmitt (R-MO) and Chris Coons (D-DE), represents a comprehensive federal legislative effort to reshape the governance and economics of intercollegiate athletics, including redistributing the significant media revenues generated by college sports. Reported favorably 19-9 from the Senate Commerce Committee and placed on Senate Calendar No. 449 on June 24, 2026, the PCSA was substantially revised on August 7, 2026 (Senate Amendment 6768). The PCSA arrives against a backdrop of cascading judicial decisions that have systematically dismantled the National Collegiate Athletic Association’s (NCAA) authority to regulate the economics of college sports.
Porto vs Manchester City Match: Champions League Live Updates
Porto hosts Manchester City at the Estádio do Dragão on Tuesday, September 8, in the opening round of the 2026-27 UEFA Champions League phase. Both teams enter the European opener in strong domestic form and will be looking to start their Champions League campaigns with a positive result. Kickoff is scheduled for 8 p.m. BST, […] The post Porto vs Manchester City Match: Champions League Live Updates appeared first on HEAVY.
Pittsburgh entrepreneur donates storage systems to Seton Hill business, technology school
The founder of a Pittsburgh-based digital storage solutions company donated $35,000 worth of equipment to Seton Hill’s cybersecurity and computer science programs. Gene Leyzarovich, former Jetstor CEO, founded the Bloomfield company more than 30 years ago while studying at the University of Pittsburgh and working night shifts at UPMC. The
BREAKING: Key Rams Player Is OUT Against The 49ers
Well, so much for seeing Aaron Donald and Myles Garrett together in Week 1. Donald will not travel to Australia with the Rams and has been ruled out for Thursday night’s season opener against the San Francisco 49ers. That’s a major break for Brock Purdy and the 49ers. Donald recently came out of a two-year…
'We're resilient': Maine businesses brace for new round of Canadian tariffs
Canada is officially striking back in the trade war with the United States.
Crossland Construction Lab opens at Bentonville High School
Area schools are working with construction companies to introduce students to industry jobs through construction programs as demand for workers rises. A construction company executive hopes the programs will lead...
Report: Dylan Larkin Shut the Door on the Flyers
The Flyers asked about Dylan Larkin and were told they are not on his list. #RedWings
49ers catch massive break for Week 1 battle vs. Rams
The 49ers are taking on the Rams in Week 1 of the 2026 season, but their division rivals won't have one of their best players for the matchup.
Celo to Participate in Merkle Science Meet in Washington, D.C. on September 8th
Celo will participate in Merkle Science Meet in Washington, D.C. on September 8th at 18:00 UTC. Markus will join a panel on the GENIUS Act and the future of U.S. stablecoin regulation.Refer to the official tweet by CELO:Kicking off @thestablecon week today, @MarkusMento speaks at @MerkleScience Mee…
DMTC gets mysterious and spooky
Whether it’s new love, enduring love, misunderstood love, or even love for the moon, it seems that every kind of love has a place in “The Addams Family.”
Staff Takeaways: Everton 2-2 Manchester United
Staff Takeaways from Manchester United’s 2-2 outing away to Everton on Sunday Colin: Everything but the finish Manchester United could not finish the job on Sunday. When attacking, they couldn’t finish moves and get the ball to a player in dangerous positions. When defending a lead, they couldn’t assert control to calm the game down […]
We redshirted our son for kindergarten. Then he skipped a grade.
We held our son back for kindergarten because of different state cutoffs. When he became bored academically, we moved him ahead a grade.
988: September 8 marks nationwide awareness campaign for mental health crisis lifeline
Georgians are being asked to tell a friend about 988 as part of a nationwide campaign marking September 8.
Group of bikini baristas win nearly $2M in legal battle
Former bikini baristas at five coffee stands in the Puget Sound region say they were paid below minimum wage and forced to turn over earnings to keep up with strict
Moment of Science: Abundant oxygen not enough to explain massive ancient insects, new study suggests
Unlocking answers about giant ancient insects! Here's why an abundance of oxygen 300 million years ago may not explain why some animals got so gigantic after all.
DMV high school football rankings (9/8/26)
WASHINGTON (DC News Now) — Here are this week’s high school football top 25 rankings compiled by DC News Now sports reporters Jake Rohm and Alex Flum. Areas eligible for these rankings are based on our coverage zone and viewing area: Washington, D.C., Montgomery County, Prince George’s County, Frederick County (MD), Fairfax County, Loudoun County, […]
Falcons drop 2 spots in Week 1 NFL power rankings
Falcons drop to No. 26 in The Athletic's power rankings: 'Things aren't looking great in Atlanta'
Small Gym September: Meet Beyond Cheer Athletics
Beyond Cheer Athletics is presenting New York City strong! Learn more about the program that is already making a name for itself from 2020 to now!
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Russell Peters opens up about race, politics and why he still needs comedy
Russell Peters talks race, prejudice, politics, and why making people laugh still matters.
Aspen School District renews membership with Valley Health Alliance
Valley Health Alliance announced today that the Aspen School District has renewed its membership, marking a significant milestone for both organizations.
Ham: Kings Rejected LaVine-Young Swap
As the Sacramento Kings continue to rebuild, the front office has clearly put a focus on getting younger. Zach LaVine and Domantas Sabonis are two players to monitor as the season progresses to see if the team is looking to deal one of their former NBA All-Stars.
The Galaxy Z Fold 8 is outselling Samsung's record-breaking Fold 7 by a wide margin
Samsung finally explained the engineering behind the gap.
Berman campaign: “We’re going fishing” – ER nurse and Democrat Mitchell Berman launches first ad of general election in Wisconsin’s First District Congressional race
Spot features Berman fishing and focuses on ending corruption in Washington, contrasting Berman’s working class background and Republican Bryan Steil’s corporate special interests RAYMOND, Wis. — Today, Mitchell Berman, ER nurse and Democratic candidate for Wisconsin’s First Congressional District, launched...
‘Furious’ creator breaks down season 1 finale and teases what’s next for Alice
‘Furious’ creator Liz Meriwether breaks down the shocking finale and what’s next for the crime drama: ‘I’m definitely not using the show as a platform to advocate murdering people.’
Scientists Keep Finding the Same Mysterious Beat Across the Animal Kingdom, From Fireflies to Sea Lions
From fireflies to mammals, evolution may have tuned communication to the rhythm of neurons.
Microsoft September 2026 Patch Tuesday fixes 966 flaws, 2 zero-days
Today is Microsoft's September 2026 Patch Tuesday, with security updates released for a record-breaking 966 flaws, including two actively exploited zero-day vulnerabilities.
DHR Health and RGV College Honor First-of-Its-Kind Nurse Apprenticeship Class
DHR Health and RGV College came together to celebrate the fifth co-hort of 10 graduates who completed the Registered Nurse Apprenticeship program.
Andy Serkis’ ‘Nevatars’ Brings a New Kind of Storytelling to Venice Immersive
Andy Serkis' Nevatars brings interactive XR storytelling, alongside ambitious projects featuring Margot Robbie, Omar Sy and Mark Ruffalo.
DHR Health and RGV College Honor First-of-Its-Kind Nurse Apprenticeship Class
DHR Health and RGV College came together to celebrate the fifth co-hort of 10 graduates who completed the Registered Nurse Apprenticeship program.
Allegri counts on European 'motivation and adrenaline' for Napoli
Coach Massimiliano Allegri is hoping the arrival of Champions League football can help put Napoli on the right track after back-to-back defeats in Serie A. Victory on the opening day against Genoa has been undermined by successive defeats at the hands of Como and Inter Milan, leaving new boss Allegri looking for a reset when his side welcome Arsenal to Stadio Diego Armando Maradona on Wednesday evening.
Why Don’t Diamondbacks Streak?
Inspiration. I very much enjoyed Jim McLennan’s The Arizona Diamondbacks Have Not Gone Streaking. I learned that the Diamondbacks have not won 7 consecutive games since 7 September 2017 (a very long time). And I tip my hat to JWinMesa for his comment to that article. A summary is that as measured by Total Streak […]
After RFK visit, board members seek new policy to keep politics out of schools
Board members look to update rules about what level of politicking should be allowed in schools.
The U.S. bishops are speaking out forcefully on politics—and finally being heard
Prompted by the beginnings of both Leo XIV’s papacy and the second term of Donald J. Trump, the bishops are using their voice in a new way.
From science to screen time: 4 key takeaways from the latest PISA results
Amid reading declines that included a 14-point drop for the U.S., researchers are looking at the role digital learning and AI may have played.
Emmet Sheehan made the most of his return
Emmet Sheehan had such a successful first start back with the Dodgers that he earned at least another, after striking out 10 Cincinnati Reds in Monday night’s win at Dodger Stadium, his first start in the majors in five weeks. “There was a lot of stuff going down, and try to figure stuff out in […]
Gov. Gavin Newsom's former chief of staff seeks to delay sentencing because of health issues
Dana Williamson, Newsom's onetime chief of staff, is seeking to delay her sentencing date for political corruption because of health issues, according to documents.
Growth in every postcode: good politics, dubious economics
The UK government would be better off backing clusters and widening access to opportunity
Vikings Re-Sign Edge Rusher Kenny Dyson To Practice Squad
Dyson is back with in Minnesota as the team was clearly impressed with his skillset.
Ink Business Unlimited vs. Spark Cash Select: Which is best?
The Ink Business Unlimited and Spark Cash Select both earn 1.5% cash back with no annual fee. But the Ink Business Unlimited is better for most businesses.
15 best TV shows to watch this fall
From a reimagining of a Stephen King classic to the return of a critically acclaimed crime drama, here are 16 shows to be excited about this fall.
Best TV shows of fall 2026: ‘Slow Horses,’ ‘Monster,’ ‘VisionQuest,’ more
From a reimagining of a Stephen King classic to the return of a critically acclaimed crime drama, here are 16 shows to be excited about this fall.
Your Business Is Growing — So Why Aren't You Making More Money? Here's the Revenue Trap Many Founders Fall Into.
More clients, more employees and more revenue can look like success. But if growth isn’t creating more profit, a stronger company and a better life, you may simply be building a bigger job.
Reshuffled college football rankings see Oregon tumble, LSU rise in US LBM Coaches Poll
The results of Week 1 of the college football season brought major changes to the US LBM Coaches Poll. Here's how the Top 25 rankings look:
New law to force tech firms to prevent children from taking nude images
The government said it will legislate "as soon as they can" but may "reassess" its plans if firms make the desired changes sooner.
USA TODAY Sports Super 15 East region football rankings, Week 4
St. Frances Academy stays solidly at the top, but a new No. 2 makes its rise.
Independent hospitals form partnership to strengethen Kansas healthcare
Five independent health systems banned together to create Astra Health, a collaboration seeking to strengthen healthcare in Kansas.
Lancaster County judge hears challenge to Nebraska K-12, collegiate sports ballot measure
A Lincoln voter refiled a challenge this week to a ballot measure seeking to cement limits on public school sports participation to student-athletes’ sex at birth after the Nebraska Supreme Court declined to hear the lawsuit.
Gone but not forgotten – Indigent Remains Ceremony 2026
The King County Medical Examiner's Office Indigent Remains Program provides burial for King County residents who have died without resources or family to claim their remains for a proper burial. The next ceremony to remember these individuals will take place on Wednesday, October 7, 2026, at 1 p.m. at Mt. Olivet Cemetery in Renton (100 Blaine Ave NE). It’s open to any member of the public who wishes to pay their respects.
Week 1 fantasy tight end rankings: Top TE streamers, starts
Chicago's Colston Loveland finished strong last season and became one of the top tight ends in this year's fantasy drafts. Where does he rank Week 1?
Federal funds headed to Tennessee rural areas lacking adequate healthcare access
The Tennessee Department of Health awarded 53 projects with funding from the Rural Health Transformation Program.
Democrats Demand Trump Administration Halt Collection of Patients' ER Records
Senate and House Democrats say the Trump administration’s plan to collect patients’ medical data violates privacy and will discourage people from seeking medical care.
Wisconsin workers see higher wages, fewer jobs, increased disparities
The median wage for Wisconsin workers is $26.17 according to a “State of Working Wisconsin” report. Job growth is slowing as racial disparities trend up.
Amazon Is Taking Preorder Requests for Pokémon TCG 30th Celebration ETBs Well Below Market Price, Marking a Rare First for US Collectors
Amazon US is accepting invite requests for Pokémon TCG 30th Celebration ETBs at $89.99—roughly $90 below market resale value on TCGplayer.
Meta Removes Iran-Linked Network That Faked American Personas to Sway US Political Debate
The Combat Antisemitism Movement (CAM) welcomes Meta’s recent removal of an Iranian regime-linked network that disguised its origins while seeking to influence American political discourse. Meta disclosed the takedown on Aug. 27 in its H2 2026 Adversarial Threat Report. The network consisted of four Facebook accounts and 31 Instagram accounts linked to actors based in […]
My National Championship Contenders After Week 1
It’s only Week 1. I’m not eliminating anybody from the College Football Playoff conversation yet, but after finally getting to watch these teams play, nine programs stand above the rest as my national championship contenders. This isn’t a ranking. There is no particular order. Ohio State Ohio State looked exactly like the No. 1 team…
Fernandes receives second Ballon d'Or nomination
Manchester United and Portugal attacking midfielder Bruno Fernandes has been named in the 30-player shortlist for the 2026 Ballon d'Or. The 32-year-old made 37 appearances across all competitions last season, scoring nine goals and contributing 22 assists, as Manchester United secured Champions League football for 2026-27.
Rebel Wolves Already Working On 'Next Chapter in The Dawnwalker Saga'
Rebel Wolves has revealed it's already working on the next game in the Dawnwalker saga after the success of The Blood of Dawnwalker.
'South Park' sends brutal message to Trump after Emmy win
"South Park" isn't done sticking it to President Donald Trump.
Egyptian TV presenter Sarah Khalifa sentenced to death in drug case
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AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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Sunderland 'deserved more' at Brentford
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Ask Pete Dougherty your questions about the Green Bay Packers
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Fantasy Football D/ST Rankings: Week 1 2026
There is plenty of fantasy football speculation running backs . And there are some undervalued tight ends . But people often forget about the defenses. Don’t do it! Pick a good one and stick with it. And here are the fantasy football defense and special teams rankings for Week 1 of the 2026 NFL season. The Week 1 list looks a lot like the usual […] The post Fantasy Football D/ST Rankings: Week 1 2026 appeared first on ClutchPoints.
Auburn launches new AI course for business leaders in Birmingham
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