SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " ADVANCE " 2,661 found 🔀 AI-powered Shuffle
Clarins Introduces Double Serum Eye, Bringing 30 Years of Longevity Science to the Eye Contour to Reduce Visible Eye Wrinkles, Puffiness, and Dark Circles
/PRNewswire/ -- Clarins, French prestige skincare brand, introduces their latest skincare advancement, the new generation of Double Serum Eye. Powered by 30...
Fort Bend County Fair Announces 2026 Entertainment Lineup Featuring Sawyer Brown, Pat Green
ROSENBERG, Texas (Covering Katy News) — The Fort Bend County Fair has announced its entertainment lineup for its 90th annual celebration, featuring a mix of Texas country stars, Tejano favorites and nationally recognized performers during Championship BBQ Weekend and the fair's 10-day run. The 2026 Fort Bend County Fair begins with Championship BBQ Weekend on Sept. 18-19, followed by the fair Sept. 25 through Oct. 4. The entertainment schedule opens Friday, Sept. 18, with Tejano group Los Morales, followed by Texas country artist Cole Phillips on Saturday, Sept. 19. Phillips has gained attention for his traditional country sound influenced by classic honky-tonk music. The fair officially opens Friday, Sept. 25, with Tyce Delk, a New Mexico native whose touring schedule has expanded across the country. Country music veterans Sawyer Brown will headline Saturday, Sept. 26. The band, whose career spans more than four decades, remains known for hits including "Some Girls Do," "The Race Is On" and "Thank God for You." Go Tejano Day on Sunday, Sept. 27, will feature Prófugos de Nuevo León, along with performances by Los Rinches and Grupo Zenio. The second week of the fair begins Wednesday, Sept. 30, with Bellville singer-songwriter David Lewis, a recent Texas Country Music Association Male Artist of the Year nominee. Oklahoma Red Dirt artist Josh Meloy will perform Thursday, Oct. 1. Texas country star Pat Green returns to the Fort Bend County Fair stage Friday, Oct. 2. Green, whose career includes three Grammy Award nominations, has sold more than 2 million albums and amassed more than 200 million career streams. He is best known for songs including "Wave on Wave" and "Carry On." Country newcomer Vincent Mason will perform Saturday, Oct. 3. Mason has accumulated more than 500 million career streams and was recently nominated for Academy of Country Music New Male Artist of the Year. The fair concludes Sunday, Oct. 4, with Texas music legend Gary P. Nunn, whose "London Homesick Blues" remains one of the state's most recognizable songs. Weekend visitors also can enjoy performances on Music Row by J Paul Jr. & the Zydeco Nubreeds, Southern County Line, Los Rangerz and Horizon. The Fort Bend County Fair Association, a nonprofit organization, supports youth, agriculture and education. According to the association, it has awarded more than $2 million in scholarships during the past decade and generated $1.4 million through its 2025 youth auctions. Tickets go on sale at 10 a.m. Friday, July 10. Guests are encouraged to purchase tickets in advance and select the specific day they plan to attend, as tickets are valid only for the date purchased. Admission includes entry to the fairgrounds, access to the carnival, shopping, exhibits, food vendors and, when scheduled, admission to the rodeo and that day's concert. Season passes and single-day tickets will be available. For tickets and additional information, visit fortbendcountyfair.com or call the Fair Office at 281-342-6171. The address of the Fairgrounds is 4310 Texas 36 S in Rosenberg. 2026 Fort Bend County Fair Entertainment Schedule Championship BBQ Weekend Friday, Sept. 18: Los Morales Saturday, Sept. 19: Cole Phillips Fair Entertainment Friday, Sept. 25: Tyce Delk Saturday, Sept. 26: Sawyer Brown Sunday, Sept. 27 (Go Tejano Day): Prófugos de Nuevo León, Los Rinches and Grupo Zenio Wednesday, Sept. 30: David Lewis Thursday, Oct. 1: Josh Meloy Friday, Oct. 2: Pat Green Saturday, Oct. 3: Vincent Mason Sunday, Oct. 4: Gary P. Nunn × Expand FBCF Fort Bend County Fair 2026 Artist Lineup
Genpact Partners with Nestlé Business Solutions to Establish New Global Capability Center
/PRNewswire/ -- Genpact (NYSE: G), an agentic and advanced technology solutions company, today announced a partnership with Nestlé Business Solutions (NBS),...
Launch Family Entertainment advances strategic growth in first half of 2026
EAST GREENWICH, R.I. — Launch Family Entertainment (Launch), a leading indoor family entertainment franchise, continued to build momentum throughout the first half of 2026 through strategic develop…
AACSB extends accreditation for La Salle University's School of Business
As the longest-serving global accrediting body for business schools, the Association to Advance Collegiate Schools of Business (AACSB) accreditation is an achievement held by only 6 percent of institutions offering business degrees worldwide.
Globavend Expands Entertainment Business Through Strategic Investment in MAMAMOO 2026 WORLD TOUR <4WARD> Hong Kong, Securing Participation in Concert Economics
Investment strengthens company's live entertainment presence and advances its AI-powered digital entertainment strategy...
Scientists finally solved a 150-year-old gallium mystery
Scientists have rewritten the story of gallium after discovering that its unusual atomic bonds re-form at high temperatures, contradicting decades of accepted theory. The finding changes how researchers explain why the metal melts so easily and behaves unlike almost any other metal. Beyond solving a long-standing scientific mystery, the work could lead to advances in semiconductors, nanotechnology, and liquid metal engineering.
In nearly seventy years of deep-sea exploration, researchers compiled 43,681 submersible dive records — and found that humans have visually observed less than 0.001% of the deep seafloor, an area roughly the size of Rhode Island, according to a Science Advances study published in May 2025.
In almost seven decades of deep-sea exploration, the direct human view of the deep ocean floor is still smaller than many people would guess. A Science
Making the 'invisible' visible: How high-speed movies could change the way scientists study disease
High-speed movies of microscopic worms may sound like a dull night at the cinema, but this advanced imaging capability could help scientists better understand how diseases begin and progress, track subtle ...
Why lithium battery and radar pioneers won China’s top science award
Chen Liquan and Ben De recognised for advances in solid-state energy storage and military aviation defence.
Michigan Democratic lawmakers introduce legislation to curb campaign spending power of corporations
State Rep. Betsy Coffia, a Democrat from Traverse City, and state Sen. Sean McCann, a Kalamazoo Democrat, introduced legislation in their respective chambers last week to limit the powers of business corporations, nonprofit corporations and limited liability companies to participate in campaign spending.
AI helped scientists discover two new superconductors, bringing them closer to a room-temperature breakthrough that could change electronics
Artificial intelligence is now fast becoming an important component in scientific investigations, and its recent achievement may have very significant effects on the advancement of technology. Scientists devised a way to utilise artificial intelligence in scientific research, which has not only resulted in the discovery of two new superconductors, but has also expedited the process of discovering even more superconductors.
Wario Land and three more Game Boy classics hit Nintendo Switch Online today
Plus Japan has received two extra Game Boy Advance games…
Trump Using Presidency to 'Boost' Family's Crypto Business While Families 'Crushed' by Rising Costs, Says Elizabeth Warren
Sen. Elizabeth Warren (D-Mass) accused President Donald Trump on Sunday of using the presidency to advance his family’s cryptocurrency interests rather than working to lower costs for the people. Warr...
Making the ‘invisible’ visible: How high-speed movies could change the way scientists study disease
An advanced imaging method captures chemical processes in living organisms in real time, allowing researchers to observe biology as it happens.
Exploring key breakthroughs in VT ablation
Today's sophisticated mapping systems allow clinicians to visualize VT circuits with unprecedented detail.
Schrödinger’s anthill: Quantum entanglement found in a crystal large enough to hold
A centimeter-sized crystal has revealed clear signs of quantum entanglement, showing that large, everyday objects can display surprisingly deep quantum behavior. The discovery could help solve the mystery of strange metals while opening new possibilities for ultra-precise quantum sensors and other advanced technologies.
Intelligent Computing appoints Philip S. Yu and Osmar R. Zaïane as new editors-in-chief
Intelligent Computing, a Science Partner Journal co-founded by Zhejiang Lab and the American Association for the Advancement of Science(AAAS), has appointed Philip S. Yu and Osmar R. Zaïane as its new Editors-in-Chief. Philip S. Yu and Osmar R. Zaïane succeed the journal's founding Editors-in-Chief at a pivotal stage of development, as Intelligent Computing continues its rapid growth as an international open-access journal dedicated to advancing the convergence of intelligence and computing.
UConn’s Innovations Institute Advances Behavioral Health Leadership Through New Partnership
The collaborative aims to elevate professional development standards, disseminate critical leadership resources, and build resilient systems of care for chi ...
Inside the BoF and Clinuvel Community Lunch Exploring the Future of Skin Health
Investors from Goldman Sachs, L Catterton and Bansk Beauty joined leaders from L’Oréal, Harrods, Space NK and Unilever at The Business of Beauty Global Forum to examine how advances in medicine, biotechnology and longevity are redefining the future of skin health.
Inside the BoF and Clinuvel Community Lunch Exploring the Future of Skin Health
Investors from Goldman Sachs, L Catterton and Bansk Beauty joined leaders from L’Oréal, Harrods, Space NK and Unilever at The Business of Beauty Global Forum to examine how advances in medicine, biotechnology and longevity are redefining the future of skin health.
Stevens courts McMorrow supporters, leans into electability pitch at small business visit
U.S. Rep. Haley Stevens, a Democratic candidate in a U.S. Senate primary that is now a two-person race, drew hard lines between herself and her primary opponent, former Wayne County Health Department executive Abdul El-Sayed, in a visit to Sea Leveaux, a Cajun boil restaurant in downtown Lansing that opened on Thursday.
The foldable iPhone may be in short supply upon release
The expected iPhone Ultra's advanced design is likely to pose challenges for manufacturing.
Partnership Advances Adolescent Health in American Samoa
Learn how American Samoa advances adolescent health in American Samoa through collaboration among state and local health and education agencies.
Joint statement from The University of Alabama and Auburn University regarding the Protect College Sports Act
The University of Alabama and Auburn University oppose the Protect College Sports Act and urge the Senate not to advance it in its current form.
From The Sports Desk: England wins in the Azteca
England and Norway advance and the USA looks to join them in the quarterfinals.
AI in the Aisles: Spectrum Business and Advanced Tech Create Happy Shoppers
For Heritage Grocers Group, speed and data aren’t just technical goals – they’re what keep the shelves stocked, lines moving and customers coming back.
NSTA and Tuva Expand Partnership to Advance Data Literacy in Science Education
NSTA and Tuva announced an expanded partnership to co-facilitate professional learning that strengthens data literacy in science education.
England survive the Azteca in instant World Cup classic
England advance to the quarterfinals with a 3-2 win over Mexico
Scientists build living ‘neurobots’ that grow their own neural networks
Self-powered, entirely biological constructs injected with neural precursor cells - reveal the surprising flexibility of nervous systems.
World Cup 2026: Erling Haaland scores twice and Norway shocks Brazil 2-1 to advance to quarterfinals
Erling Haaland added two more goals for Norway en route to a 2-1 win.
Speaker Johnson says House will pass Trump’s voter ID bill through arduous process after GOP revolt
House Speaker Mike Johnson said he plans to move quickly to advance President Donald Trump’s signature voter ID legislation through the arduous budget reconciliation process once the House returns to Washington, downplaying the heightened tensions within the GOP after he sent lawmakers home early for the holidays after a few Republicans brought the floor to a halt.
Superintelligent AI in space could explain the Fermi Paradox
Why haven't we found evidence of advanced aliens? It could be that they've outsourced cosmic exploration to superintelligent AI, a new paper suggests.
China rare earth industry has critical weakness, study finds
New study finds China lagging behind Japan and the US in key patents for advanced rare earth technologies.
Scientists have now made the most comprehensive tally yet of deep-sea exploration — 43,681 dive records dating back to 1958 — and found that humans have directly seen less than 0.001% of the deep ocean floor, an area roughly the size of Rhode Island, leaving the vast seafloor across 66% of Earth’s surface essentially unobserved.
Humanity has sent cameras to the Moon, Mars, Venus and the outer planets, but on Earth itself there is still a larger frontier that has barely been looked at directly. A 2025 study in Science Advances has now put a number on that gap: since 1958, researchers have compiled 43,681 records of dives deep enough […]
2026 World Cup Bracket: Live Look At Quarterfinals Matchups
Here is what the 2026 FIFA World Cup quarterfinals bracket looks like as teams advance.
The Selective Frontier: The State of the American Experiment After 250 Years
Since its inception, America has revolutionized scientific research and technological advancements. Yet, in its shift away from federal research grants and “basic research,” science may find itself in an increasingly privatized and profit-driven setting.
UVM Health Network employees advance careers through Pathfinder Program
UVM Health Network employees are building their futures through the Pathfinder Program, a partnership with the Community College of Vermont.
UVM Health Network employees advance careers through Pathfinder Program
UVM Health Network employees are building their futures through the Pathfinder Program, a partnership with the Community College of Vermont
From The Sports Desk: Portugal advances, Croatia sent packing after dramatic finish
Cristiano Ronaldo played hero yesterday, leading Portugal to a 2-1 win over Croatia, which had a late equalizer taken away on replay review. Now, Portugal takes on Spain next.
Scientists make quantum time flow backward in stunning physics breakthrough
Researchers have created quantum control techniques that can make a system appear to run backward in time. By precisely managing quantum measurements, they can reshape the system's arrow of time and even harvest energy from the measurement process itself. The breakthrough could lead to more powerful quantum computers, quantum batteries, and other advanced technologies.
Amendment 61: A.4 Rapid Response and Novel Research in Earth Science Final Close Date Deferred
A.4 Rapid Response and Novel Research in Earth Science (RRNES) solicits proposals that advance the goals and objectives of NASA's Earth Science Division by
SBA, USDA Sign MOU to Combat Lawfare Against Farmers, Ranchers, and Small Businesses
New Partnership Gives Producers a Direct Line to Report Costly Regulations and Advance Lasting ReformWASHINGTON, July 02, 2026 (GLOBE NEWSWIRE) -- Today, the U.S. Small Business Administration (SBA) and the U.S. Department of Agriculture (USDA) signed a Memorandum of Understanding (MOU) to combat lawfare targeting farmers, ranchers, rural communities, and small businesses. The agreement gives America’s producers a direct line to report the regulations and rules driving up costs and impacting pro
Announcement: New Leadership at the NJ Institute for Food, Nutrition, and Health (IFNH)
Announcement by Laura Lawson, SEBS Executive Dean and NJAES Executive Director I am pleased to announce new leadership for the Institute for Food, Nutrition, and Health (IFNH), positioning the institute to further advance Rutgers University’s commitment to excellence in food, nutrition, health, and community engagement. I would like to thank the faculty members whose contributions […]
From The Sports Desk: The U.S. advances, but loses Folarin Balogun to costly red card
The U.S. beat Bosnia-Herzegovina 2-0 to advance to the round of 16, where it will face Belgium next. But the U.S. will be without Balogun, its top goal-scorer of this tournament.
Marshall Health Network first in West Virginia to offer histotripsy treatment for liver tumors
HUNTINGTON, W.Va. – Marshall Health Network–Cabell Huntington Hospital (CHH) is the first hospital in West Virginia to treat liver tumors using the Edison® Histotripsy System, giving patients access to an advanced treatment that targets tumors with focused sound waves instead of surgery, chemotherapy or radiation. The Edison Histotripsy System uses image-guided sonic beam therapy to precisely target […]
How remote patient monitoring advances affordable healthcare
As global medical costs face double-digit spikes, remote care is a clinical tool and an economic necessity.
Croatia criticised for ‘unambitious’ changes to 2022 science law
Croatia’s science ministry has been accused of a lack of ambition, and even incompetence, over proposed changes to the country’s 2022 science law. Critics say an opportunity has been missed to fix wider shortcomings in the research and universities system.“This law, like all the previous ones, will not significantly change the current state of science in Croatia,” Vlatko Silobrčić, a member of the Croatian Academy of Sciences, told Science Business. “A small shift here and there will not have a significant impact.”The 2022 law introduced multi-year block grant financing of research, based on results, and changes intended to boost employment and career progression for researchers and lecturers. But implementation of the law has been uneven. “It became apparent that certain of its provisions were subject to different interpretations by higher education institutions and scientific institutes,” the science ministry said in its proposal for change. “This caused legal uncertainty in the system, administrative difficulties in implementation and, in certain cases, unequal treatment of teachers, scientists and students.”Most of the proposed amendments deal with technicalities in hiring and promoting staff, such as extending the committee deadlines from 60 to 90 days, or allowing applicants to cite all of their achievements and not only those since their last appointment.Both the ministry and Croatian media highlighted changes that would raise the retirement age from 65 to 67 years and allow part-time students 15 year rather than 10 years to finish their studies.The change to retirement age has been criticised for reinforcing a weakness in the system. According to Matko Marušić, professor emeritus at the University of Split, this will “allow unproductive teachers to advance and work longer, while hindering and discouraging productive ones.”A longtime campaigner for excellence-based meritocracy, he sees little hope in the new legislation. “I am not optimistic that things will improve,” he told Science Business. “As recent changes to the law in Croatia show, the legal framework is becoming increasingly hypocritical and harmful.”For Marušić, who analyses Croatia's university system in a recently published book, the situation is “unfavourable and constantly deteriorating” due to the criteria used for academic advancement.“The key criterion for advancement should be scientific productivity,” he said. “In Croatia [. . .] scientific criteria are increasingly lowered, and ineffective and absurd criteria such as waiting times for promotion and age limits for remaining in a job are promoted.” He would also like to see better criteria for the quality of teaching at universities. “In practice, teaching is not monitored or evaluated,” he said, estimating that up to a third of teaching simply does not take place. “Under the guise of university autonomy and bad laws, universities and faculties are allowed to earn additional money by increasing enrolment quotas that have nothing to do with the needs of the labour market.” Lack of ambitionDora Kršul, a reporter at Telegram.hr who covers science policy in Croatia, finds the rationale for changes “bizarre.” “The ministry responsible for supervising the uniform application of the law is changing the law because it is being implemented unevenly,” she said. “This primarily speaks to the power relationship in the sphere of science and higher education in Croatia, that is, the question arises as to who actually manages this system.”Rather than raising quality, she continued, the changes appear to be designed to help vocational and applied universities who have not been complying with the law.The Independent Union of Research and Higher Education Employees of Croatia said that the changes were “unambitious” and represent a missed opportunity for more important changes. “We think some of the changes are even negative,” it said in its statement on June 25. One of these is introduction of an “assistant” job title that allows people to be hired only for the duration of a project. Related articles: Elections to top science bodies test Croatia’s gender equality in researchSlovakia revises R&D approach to increase focus on competitivenessLatvia pilots citizen engagement in research grant evaluationsThe union’s president, Tvrtko Smital, who was part of the 15-member working group tasked with drafting the changes, told the local media there was a “worrying lack of ambition” in the process, and “lack of competence” in terms of research experience and understanding the problems in the system.“There is no clear will to deal with the problems,” said Smital, an assistant professor of marine and environmental sciences at the Ruđer Bošković Institute in Zagreb. “It’s a combination of unambitiousness and incompetence,” he went on, expressing his “deep frustration” with the situation. “There is no strategy, no clear thinking, and money is not being spent optimally.”Croatia’s science ministry has not responded to requests for comment.
Meta Is Charging a Subscription for Smart Glasses Features. Welcome to the New Era of Consumer Tech
You bought the hardware. Now you’ll need to subscribe for “expanded access” to the most advanced features.
Bayer Group to consolidate U.S. glyphosate business into distinct entity operating as Ruveon
Advances key component of Crop Science division’s Five-Year Framework strategy / Reinforces commitment to delivering trusted Roundup® brands and glyphosate products and services to U.S. customers
Canes football remains on a recruiting surge. And basketball team adds a center
UM football, basketball teams keep up momentum in recruiting.
Army experimenting with mobile business apps
The events are also revealing where industry is building redundant software, the Army said.
SpudCell: Scientists Made a Cell With Most of the Hallmarks of Life. Here’s What to Know.
From why it was created to whether it’s alive, here’s what to know about SpudCell, the latest advance in synthetic biology.
The Supreme Court’s trans sports ban ruling is about exclusion, not safety, advocates say
The Supreme Court can't stop using biological arguments to advance bigotry. In a 6-3 ruling, the justices sided in favor of state laws that ban transgender athletes from women's sports teams, citing unfair competition and physical danger.
Sony will cease production of discs for new PlayStation games in 2028
New games sold for PlayStation consoles will only be available digitally and won’t be sold on discs effective January 2028, Sony has announced. The move applies to all PlayStation games released from that point on, including those made by Sony and those released by third parties. The PlayStation group calls the change “a natural direction for Sony Interactive Entertainment to adapt to consumer trends as the general preference for digital media significantly outpaces physical discs,” according to a PlayStation blog post reviewed by Game File in advance of its publication. As movies, TV and music have shifted from physical media to an age of downloads and streaming, Sony’s move could speed the demise of physical media in a gaming. The industry has offered consumers games via cartridges, cassettes, floppy discs, CDs, DVDs and Blu-Rays across a 50-year stretch. Sony has been reporting to investors in recent years that PlayStation games have been increasingly purchased as downloads, not as discs. The most recent figures show nearly four in five purchases of full games for PlayStation 4 and PlayStation 5 were purchased digitally in the past year. Stats like that may cause today’s news to carry an air of the inevitable. But Sony’s declaration for 2028 is still likely to produce a shock, as the biggest gaming platform on the planet that uses game discs leaves them behind. Discs going away, but the fate of game boxes is unknown Sony is committing to still selling games in physical retailers even after they drop discs in 2028. Just how those games will be sold—in boxes with codes inside, as cards marked with digital redemption codes—is unclear. Digital games will also continue to be sold in the online PlayStation Store. New games released for PlayStation consoles prior to January 2028 will be unaffected by the policy change, Sony says. That means the PS5 games of 2027, be they a new Madden, a new God of War, a new Call of Duty, a new Sly Cooper (one can dream?), would still potentially be offered on disc. PlayStation 6 implications Sony’s timeline for a transition to a no-disc era will also spin up more speculation about the timing and configuration of Sony’s next-generation console, the probable PlayStation 6. “This pretty much guarantees that PS6 won’t arrive until 2028 at the earliest,” Piers Harding-Rolls, senior games research analyst at Ampere Analysis tells Game File. Harding-Rolls also concludes from today’s news that “the base version of a PS6 will not include a physical media drive,” as Sony looks to keep costs down on the device. Sony itself is saying nothing about the PS6 today: not its timing, nor how it might or might not support internal or external disc drives in order to run disc-based PS4 and PS5 games, should the console be backwards compatible. The many signs this was coming Industry support for games being released on physical media has been waning. As has consumer interest in them. PC games effectively went all-digital years ago, thanks to the popularity of playing games through Steam and other digital storefronts. The Covid-19 pandemic and the lockdowns that kept much of the global population home helped shift shopping patterns toward downloads. Sony’s own data shows PlayStation game downloads being an uncommon consumer choice a decade ago and now becoming the norm. On consoles, physical media has been in such decline that Sony and Microsoft both launched their current gen Xbox Series and PS5 consoles in 2020 with cheaper versions that lacked disc drives. In early 2024, Phil Spencer, then head of Xbox, told me that ““[w]e ship games physically and digitally, and we’re really just following what the customers are doing.” He added that the game industry had become an outlier in still supporting disc-based entertainment, even as movies and TV have bailed on discs in favor of downloads and steaming: “Gaming consoles themselves have kind of become the last consumer electronic device that has a drive. And this is a real issue, just in terms of the number of manufacturers that are actually building drives and the cost associated with those. And when you think about cogs that we’re going to go put in a console—and as you have fewer suppliers and fewer buyers—the cost of the drive does have an impact.” Last year, the Nintendo’s Switch 2, which uses cartridges rather than discs, introduced the concept of game-key cards, which are physical media that contain no game, just a prompt for a download. Even disc-based games aren’t what they once were, now frequently containing just stubs of games rather than the whole thing. The website Does It Play has tested over 3000 games and found that, for example, that the disc version of this year’s hit 007: First Light, only contained the game’s first mission, with the rest needing to be downloaded. Beyond all that, last week brought the news that Grand Theft Auto VI, likely the biggest game launch this decade, will debut for PS5 and Xbox Series without a disc-based version. Today’s big news comes to you for free. Game File is a reader-supported publication. To receive new posts and ensure more of my work is possible, please consider becoming a free or paid subscriber. Subscribe Discs helped define PlayStation However the trends in entertainment may be going, it is still remarkable to see PlayStation ditch discs given their importance in PlayStation history: In the late 1990s, the first PlayStation’s support for games on relatively cheap CD-ROMs instead of traditional game cartridges allowed the upstart console to outmaneuver cartridge-based systems from Nintendo and Sega, as it drove down game prices down in the process. (The cheaper disc format even prompted Final Fantasy VII maker Square to taunt Nintendo in a magazine ad, saying that if the game was “available on cartridge, it’d retail for around $1200.”) PlayStation devices often doubled as machines for watching movies and TV on the latest disc-based formats. In the late 2000s, for example, Sony’s pricy PS3 gained traction as a go-to device for playing then-novel Blu-Ray discs. In 2013, Sony effectively roasted the digital game-sharing restrictions proposed by rival Microsoft for its upcoming Xbox One console by showing how games could be shared for the then-upcoming PS4. In a 21-second clip that has over 20 million views on YouTube, one PlayStation executive simply handed a game box—presumably with disc inside—to another, who said “thanks.” Sony’s possible motivations The PlayStation announcement today cites “consumer preferences” and a shift away from discs among “the broader entertainment industry,” but does not delve into the decision-making process that brought Sony to this point. Sony is not discussing the economics of this move (I asked!), but there are a number of potential factors: Abandoning discs will spare Sony the cost of manufacturing and shipping them, which analysts and industry veterans I spoke to said could account for $1 or so of a game’s retail price. For first-party games, that’s direct savings for Sony, though the amount is limited by the winnowing percentage of people who were even buying the disc-based versions. For third-party games, Sony could pass the savings on to partners or just retain the better profit margin for themselves. As the 2024 comments from Phil Spencer alluded to, leaving discs behind could mean leaving disc-drives behind, allowing Sony to produce consoles more cheaply. Switching to digital-only for games could diminish the risks of copies of new games leaking. It would also seemingly make second-hand sales of used games impossible, pushing more people to buy their own copies of games. These economic benefits for Sony could be boons for the games industry overall, Ampere analyst Piers Harding-Rolls tells Game File. Among other things, it could free publishers and retailers from having to worry about securing an inventory of game discs when trying to sell games, he noted. “If there is a way to streamline the business of games retail, I generally think it’s a good thing for the industry as it removes unnecessary costs,” Harding-Rolls said. “This will help offset pressure on margins from other directions – development and staffing costs for example.” Should the industry shift from game boxes that contain discs to smaller, cheaper game cards, Harding-Rolls said, that reduces pressure on publishers and retailers. “The advantage of everything going digital for the industry is that sales can be tracked much more easily and there is less commercial risk for publishers wanting to continue selling via retail,” he said. The shift to no discs will also likely impact game development timelines, as developers will no longer face the same urgency to have a build ready to submit to PlayStation for the production of a disc, as industry experts noted around GTA VI’s no-disc news last week. Instead, projects may gain weeks of development time, in the event delivery deadlines for platform approval move closer to release date. Preservationists’ likely worries While millions of gamers have shifted to digital, there are still people who associate game discs—and only game discs—with actual ownership of PlayStation games. That portion of the gaming community spoke up last week about wanting to buy a version of GTA VI that they could hold in their hands, could lend to a friend and could potentially pop into a well-preserved PS5 console three decades from now and still see it run. Such gamers didn’t want to worry that they’d merely purchased a digital copy that could lose access to the game if, say, the company behind the game someday turns of the servers that transmit downloadable copies. Digital copies of games are inherently less long-lasting, because consumers aren’t actually buying a game (on a disc), just buying access to the game. The fine print in online gaming shops notes this, as does a recent law that went on the books in California in 2025. That lasw requires game publishers doing business in the state to refrain from words like “sell” when offering digital copies of games, unless they explicitly tell consumers that what’s being sold isn’t the game itself but a potentially revocable license to access it. A Sony spokesperson noted to Game File that “[w]ith all digital content, including games, movies, and music, players are purchasing a personal license for non-commercial use.” Regarding the fears of PlayStation games being lost to time in an all-digital era, the rep also noted that Sony remains “committed to delivering experiences from past generations to the new platforms our players are using.” They noted that PlayStation has used emulation and remasters to keep offering its classic games to modern gamers. It’s true that many consumers have become accustomed to not having physical copies of new music albums or movies, but the relative precariousness of digital copies of games is in fact being highlighted today by…. Sony’s other big announcement: the upcoming closure of the PS3 and PS Vita online stores Sony said today that it will be closing the online marketplaces for its PlayStation 3 console and PS Vita handheld in most countries in July 2027 (sooner elsewhere: August 2026 for the PS3 store Mexico, Honduras and Nicaragua; late 2026 for PS3 in other Latin American countries and the Middle East). “We know this news may be disappointing to PS3 and PS Vita players who hold a special place in their hearts for this generation of gaming,” Sony said in its announcement, saying the move “was not an easy decision for us to make.” Sony said that PS3 and Vita marketplaces “are no longer able” to support modern commerce systems, prompting a “need” to close the shops and focus on more modern PlayStation platform stores. The news may spark some deja vu. Sony announced back in March 2021 that it planned to take the PS3, Vita and PlayStation Portable marketplaces offline that summer. The move would have caused some 2,000 digital-only games to become unavailable for new purchasers, according to a VGC analysis at the time. Fans complained loudly. By April 2021, Sony walked back the PS3 and Vita shop closures, with then PlayStation boss Jim Ryan saying “it’s clear that we made the wrong decision here.” This time around, Sony is giving a longer notice period in most regions. The closure of those stores is still likely to cut off access to new purchases of digital-only PS3 and Vita games. The current PlayStation 5 marketplace sells PS5 and PS4 games, as well as a selection of PS1 and PS2 games. It does not sell PS3 games, because games for that platform can’t run on the system (some are offered via a PlayStation Plus streaming option). Vita games also aren’t sold via PS5. Sony says digitally purchased PS3 and Vita games will be downloadable after the stores’ shutdowns “for the foreseeable future.” Sony’s move contrasts with Microsoft’s Xbox platform, which continues to sell and support games from all four Xbox console generations. But it puts it in line with Nintendo, which disabled purchases in the marketplace for its Wii console (a contemporary of the PS3) in 2019. Nintendo discontinued purchases in the online shop for its 3DS portable (a contemporary of the Vita) in 2023. The big questions about Sony’s 2028 post-disc era Will Microsoft follow suit, ending support for new disc-based games on Xbox platforms and therefore all game consoles, too? Whether Microsoft does or not, will third-parties that can no longer release games on discs for PlayStation, simply ditch the disc options across the board? Given the GTA VI no-disc experiment launching this November, will more game publishers decide to forgo disc-based offerings even in 2027? How will no-disc PS5/6 games be packaged and sold in brick-and-mortar retail stores? What becomes of game sharing in an all-digital era? Will Sony modify its current set-up, which currently allows some sharing of digital games across a pair of consoles, to allow more casual lending? (See for example, Nintendo’s year-old system of letting players lend a digital game to another player in a “family group” for up to 14 days.) Will there be a version of a PS6 with a disc drive? Or will a drive be offered as an add-on? And how will gamers who want to retain access to PS4/PS5 disc-based games react to whichever configurations Sony chooses to offer? What will the final disc-based PlayStation game be?
Lawmakers must put women’s health, dignity and lives ahead of politics
Each year since the fall of Roe, the Louisiana Legislature has advanced increasingly aggressive versions of the state's abortion ban, often under the guise of targeting bad actors.
Lawmakers must put women’s health, dignity and lives ahead of politics
Each year since the fall of Roe, the Louisiana Legislature has advanced increasingly aggressive versions of the state's abortion ban, often under the guise of targeting bad actors.
Nearly 100% of patients surveyed say they’d want to know when AI is used in imaging
Researchers recently sought to better understand how patients perceive rapidly evolving advancements in AI, sharing their findings in RSNA’s Radiology.
Children’s Hospital Los Angeles’ 2026 TSRI Science Day Highlights Advances in Cancer Biology
June 17 saw more than 400 scientists, clinicians, research staff, and other Children’s Hospital Los Angeles team members come together for The Saban Research Institute’s (TSRI) yearly symposium and poster session—Science Day 2026.
Supreme Court rules states can restrict transgender athletes’ sports participation in schools
The decision marks another legal setback for transgender youth as the Trump administration and Republican-led state legislatures have advanced policies limiting transgender rights.
Nokia, SAP and Microsoft Enter Strategic Multi-Year Agreement to Advance Cloud- and AI-Driven Business Transformation
Nokia will accelerate its enterprise transformation using RISE with SAP Methodology, with SAP S/4HANA hosted on Microsoft Azure.
Round table: Manufacturing Revoultion
••• SPONSORED SECTION ••• Manufacturing historically has conjured a certain perception, one of low skills, low pay and low advancement. But times are changing, and they’re changing fast. Spurred by North Carolina’s often lauded economic environment, manufacturers from a variety of sectors are advancing, investing and expanding across the state. But those moves come with […]
SGMC Health Welcomes 32 Resident Physicians
SGMC Health welcomes its newest cohort of resident physicians as they begin their clinical training, representing a significant milestone in the continued advancement of the organization’s Graduate Medical Education (GME) program.
Kristen Hogan joins Essentia Health-32nd Avenue Clinic to practice nephrology
The Essentia Health-32nd Avenue Clinic is excited to welcome Kristen Hogan, an advanced practice registered nurse and certified nurse practitioner in nephrology.
Honeywell completes spin-off into three companies. Just one remains in Charlotte.
The three businesses separately focus on advanced materials, automation and aerospace.
Indy economic development leaders visiting Switzerland on trade trip
The trip will involve meetings with leaders in the life sciences, biotechnology and pharmaceuticals, medical technology, digital heath and advanced manufacturing sectors.
Cornell Yang Center for Wildlife Health awards seed funding to five conservation efforts around the globe
The CCF provides catalytic seed funding to spark pioneering applied research to advance wildlife conservation solutions. The fund prioritizes initiatives that improve the health of free-ranging wildlife and/or solve environmental problems via a One Health lens.
When sushi meets schools in rural Colorado, everyone wins
NATHAN YIP FOUNDATION Greenwood Village By JOANNE DAVIDSON SPECIAL TO COLORADO POLITICS News: Sushi-lovers from Denver and beyond know that they’re in for a treat when the Nathan Yip Foundation hosts its annual Sushi Party. The rush to purchase tickets begins months in advance and when the big day arrives, the event space atop The Dome at AMG is filled to capacity. […]
Essentia Health-Cloquet Clinic welcomes Jaycee Hewitt to practice family medicine
Jaycee Hewitt, an advanced practice registered nurse and certified nurse practitioner in family medicine, is thrilled to join the Essentia Health-Cloquet Clinic.
Union Pacific And Norfolk Southern: How Politics Can Have A Body Count
Advances in goods shipment must be achieved not to bring harm to the trucking industry, but to protect increasingly acquisitive Americans from death born of their wealth.
NEA Nuclear Science Committee advances strategic priorities for the future of nuclear research
The NEA Nuclear Science Committee met on 8-10 June 2026 to advance international collaboration, strengthen scientific expertise, and shape the future of nuclear science through innovation, data and AI.
New research shows the hidden challenges facing religious scientists
A recent study from Rice’s Boniuk Institute for the Study and Advancement of Religious Tolerance titled “Religious Representation in Science: How Scientists in the United States, Mexico and South Africa Respond” explores the aspect of religious representation in science.
UNESCO launches open-source platform to advance global open science
Open Science Platform has been released as free and open-source software and is built on open technologies
After months of unanswered pain, a Philly woman learned she had Stage 3 colon cancer. Now she’s pushing for equitable care
Medical advances mean that more people are surviving cancer. But not everyone is benefiting from those gains equally, a new report shows.
Medicare pushes end-of-life discussions in hospitals
Questions about living wills and other "advanced directives" are often skipped — or become a box-check in the admissions process.
House committee advances radiology-backed legislation to curb prior authorization
The Improving Seniors’ Timely Access to Care Act seeks to streamline the “often cumbersome and time-consuming” task of approving requests for medical imaging in Medicare Advantage.
Verizon, BT Are Said to Near JV Deal for International Business
Verizon Communications Inc. is in advanced talks to combine some of its international business with that of the UK’s BT Group Plc, according to people familiar with the matter.
Ted Cruz bill to regulate college sports in NIL era advances
The Texan said he hopes the proposed changes, written with a Democratic senator, can save athletics from a stark separation between the haves and have-nots.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Austria lobbies EU to host Anthropic AI after US curbs, Bloomberg News reports
Austria is pushing the European Union to consider hosting Anthropic AI system within its borders to counter efforts by the U.S. to block foreigners from using the company's most advanced models, Bloomberg News reported on Sunday.
International Business Machines (IBM) Is A Top Stock In Billionaire Richard Chilton’s Filings
International Business Machines Corporation (NYSE:IBM) is one of the 10 Best Stocks to Buy According to Billionaire Richard Chilton. Technology giant International Business Machines Corporation (NYSE:IBM) made a key announcement recently when it announced its 0.7-nanometer chip manufacturing technology. This technology is the most advanced chip manufacturing technology in the world. International Business Machines Corporation […]
Alzheimer’s research headlines 2026 brain health summit
The summit, hosted by the University of Hawaii John A. Burns School of Medicine, highlighted the latest advances in Alzheimer’s research.
Alzheimer’s research headlines 2026 brain health summit
The event featured presentations on recent Alzheimer’s advancements.
Could 'humanmaxxing' actually help you live longer? Here's what experts say
Humanmaxxing is the latest wellness trend focused on maximizing human potential through biohacking, longevity science and advanced medical treatments.
Could 'humanmaxxing' actually help you live longer? Here's what experts say
Humanmaxxing is the latest wellness trend focused on maximizing human potential through biohacking, longevity science and advanced medical treatments.
2026 World Cup: Colombia wins Group K thanks to Portugal draw as DR Congo also advances
We won't get a meeting between Messi and Ronaldo in the quarterfinals.
You’ve never seen this before: the shocking moment the sound barrier breaks - Futura-Sciences
The XB-1 is a critical stepping stone toward commercial supersonic travel, representing the first civil designed aircraft to break the sound barrier since the Concorde retired. To verify the aircraft’s aerodynamic performance during its supersonic transition, NASA deployed an advanced optical technology called schlieren imaging to make the invisible forces...
So many colorful Samsung Galaxy Watch 9 and Galaxy Watch Ultra 2 bands leaked ahead of launch
Anyone opting for the new Galaxy Watch9 or the redesigned Galaxy Watch Ultra 2 after July 22 will be spoiled for choice. Lots and lots of watch bands in different styles and colors will be available from Samsung at launch, as roughly 60 images leaked in advance shows.
Fallout from USMNT loss to Turkey and previewing the Mbappe-Haaland clash
On today’s show, we look back at the United States’ final group stage match against Turkey and evaluate their readiness for the Round of 32. Manchester City insider Sam Lee joins us to preview the tournament’s first true superstar heavyweight clash as Kylian Mbappe and France square off against Erling Haaland and Norway in a battle for Group I supremacy. Plus, The Athletic’s Jay Harris is back in the studio to break down the latest bracketology, advancement percentages, and qualification permutations for Groups G, H, and I using The Athletic’s World Cup Tracker.
Trossard, De Bruyne score and Belgium defeats New Zealand 5-1 to advance at the World Cup
A flurry of late goals helped secure Belgium’s place in the knockout rounds, while New Zealand are heading home without a win.
Nia Long explains why she turned down Prince's advances
The "Michael" actress said that she later met Prince a second time: "He was lovely, but we talked about my hair the whole time."
Nia Long explains why she turned down Prince's advances
Nia Long explained why she once shut down Prince's advances when she was young, and said that she later met the musician again when she'd gained more notoriety in Hollywood.
Medical Debt Bills Advance, House Hears Behavioral Health Testimony
Several healthcare-related bills advanced in the Michigan Legislature during the week of June 22, including legislation addressing medical debt collections and behavioral health screenings.
Council Explores AI, Quality Improvement and Patient Safety to Advance Community Health
The MHA Council on Health Access and Community Impact held its final meeting of the program year June 4 to examine emerging opportunities and challenges shaping healthcare delivery and advancing community health.
OHSU advances massive leap in medical science with cellular therapies
Patients are benefiting from CAR-T to treat neurodegenerative diseases, cancer, lupus and other autoimmune conditions.
Federal AI security center measure advanced by House Science
A measure that would put into law a key federal office focused on artificial intelligence advanced Thursday out of the House Science, Space and Technology Committee, as part of a slate of AI-focused and data center bills. The committee advanced the bills on a bipartisan basis, but put off potential changes regarding funding levels for […]
Medical breakthroughs collide with the health system
The buzziest advances — like personalized gene therapies or AI-discovered drugs — may not deliver.
Senate Indian Affairs Committee Advances Mark Cruz’s Nomination to Lead Indian Health Service
U.S. Senator Lisa Murkowski (R-Alaska), Chair of the Senate Committee on Indian Affairs, led a nomination hearing to consider Mr. Mark Cruz, of Oregon, to be Director of the Indian Health Service within the U.S. Department of Health and Human Services and expressed her intent to support his nomination. Representative Tom Cole (R-Okla.), a citizen […]
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Microsoft Discovery Aims To Advance The Era Of Agentic Science
The cloud-based agentic AI platform aims to help human researchers overcome resource constraints and complex data challenges to accelerate science at scale.