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Virginia Tech banking on health, continuity to make NCAA Tournament push
“To retain your core and guys that have done it and good players ... it’s a big, big deal,” Mike Young said.
This Halos Hustle Player Deserves A Role Next Year
The Los Angeles Angels picked up Wade Meckler early in the season, and he became a great story.
Mississippi State’s Josh Hubbard Needs More Help, Not More Points
Josh Hubbard has already shown the nation that he can be one of the best scorers in the country, no matter how heavy his workload is. As he returns for his senior season at Mississippi State, the main question is whether the players around him can provide sufficient support to get more wins in the …
PlayStation Store Sale “Player’s Choice” Live on October 7
Sony has a new PlayStation Store sale live now, and it's called the "Player's Choice" promotion. In total it has 4955 items included, though this includes a game's different editions,…
Stacy’s Streamers: Five Players to Start in Week 5
Stacy Perez highlights at least one player at each position who is worth streaming in Week 5.
La Liga's new market values 🤑💸
That's a lot of zeros.Between the World Cup, the start of the season and the transfer windows, players' market values have been shaken up this summer.From new arrivals to dramatic drops and massive ri...
Toronto Blue Jays Signing: Team Agrees with Young International Player
Cayro Hazel has spent the last two years playing in the Dutch Major League.
Joel Klatt Says Michigan’s Scheme Doesn’t Fit Its Players
Joel Klatt called Michigan's loss at Minnesota and walked away blaming something bigger than the players. #GoBlue
All 50 States Should Legalize The 'Booming Business' Of Marijuana, Brittney Griner Says
Brittney Griner, the professional basketball player who was previously incarcerated in Russia over possession of marijuana, says it’s time for cannabis to be legalized across the U.S., citing its role as a safer alternative to painkillers that athletes are commonly prescribed. “At this point, I feel like all 50 states…just might as well” legalize marijuana, […]
Chelsea’s Sporting Director Succession Plan Revealed Following Lawrence Stewart's Departure
As Laurence Stewart exits Stamford Bridge, a new leadership structure emerges to steer transfer strategy and player pathways under the guidance of manager Xabi Alonso and Behdad Eghbali in a cohesive plan.
Every Wyoming player drafted by the Boston Celtics
Let's take a look at every player who has been drafted by the Celtics out of Wyoming.
Maximilian Eggestein explains what makes ‘the perfect Freiburg player’
SC Freiburg midfielder Maximilian Eggestein has spoken at length on his role within Julian Schuster’s side, the importance of sacrificing individual ambitions for the collective and his plans to rem...
Vikings Part Ways With Four Players, Including Devin Neal
Minnesota made a series of roster moves Wednesday, releasing three players from its practice squad while waiving cornerback Tyreek Chappell from injured reserve.
Wisconsin women's basketball coach sees new players bond early
Badgers coach Robin Pingeton is reassembling the team with several newcomers and says they're already showing initiative.
Kyren Williams, Kenneth Walker: First players since 2016 with 2 TD runs in last 4 minutes
Show ambition or stay at home
QPR boss Julien Stephan says his players must show ambition at West Ham on Friday night - or otherwise "stay at home".
Why Lennart Karl’s Bayern future could hinge on Michael Olise
At the age of 18, Lennart Karl has already established himself as a first-team player for Bayern Munich and as a Germany international.Following his breakthrough season in 2025/26, the question now is...
‘Crystal Ball’ – Sports Media Analyst Predicts Fox Will Lose Greg Olsen, Prompting a Drew Brees Promotion and ESPN Star Getting Poached
With the NFL season well underway, it appears the broadcasting world could see a couple of shakeups. With Tony Romo’s exit from CBS, attention is also turning to other player-turned analysts, including Greg Olsen’s situation at Fox, which is expected to create a ripple effect in sports broadcasting.
Tennessee Titans swap multiple players on practice squad
The Tennessee Titans shuffled their practice squad roster ahead of Week 5 by adding three new players.
Pellegrini favored to start in Como-Roma
Gian Piero Gasperini is ready to welcome back the remaining players who have been on international duty, preparing for the trip to Como, scheduled for Sunday at 12:30 PM. Mora, Castro, Soulé, and Bal...
Lionel Messi ends Argentina career with goal and two assists against Benin on emotional night
Lionel Messi finishes his international career with 208 senior caps, the most of any player in the teams history, with his 126 goals for Argentina also a record; On an emotional night against Benin, Messi also created the first two goals, before getting on the scoresheet himself
Why ‘Wives’ is relevant to the times
Parvesh Cheena, actor in Jaclyn Backhaus’ play WIVES, at East West Players, co-produced with Hypokrit Live Arts. Photo by Daniel Antonio Vallejo. At a time when marginalized voices are changing the national conversation, Jaclyn Backhaus’ play Wives, featuring a South Asian American cast, is both relevant and funny. “This play offers its actors the opportunity to time travel, to play many…
Texas QB Arch Manning Receives Bad News From “NFL Folks”
The Texas Longhorns quarterback Arch Manning entered the 2026 season carrying enormous expectations, including plenty of discussion about eventually becoming one of the first players selected in the NFL draft. Just four games into the season, however, at least one prominent NFL draft analyst believes Manning has significant work to do before reaching that level.CBS […] The post Texas QB Arch Manning Receives Bad News From “NFL Folks” appeared first on HEAVY.
Cook and Holmquist, the newest inductees into Nebraska Athletics Hall of Fame
Nebraska volleyball welcomes two new inductees into Husker Athletics Hall of Fame, previous head coach John Cook and former player Amber Holmquist. This pair has paved the way for Husker volleyball and women’s sports as a whole.
Boston Celtics News: Joe Mazzulla, Players, Reflect on Summer Tour
The C's head coach visited several players in their home town.
Former Bengals teammate makes interesting Jordan Battle comments
Now former Bengals players have weighed in on the Jordan Battle debate.
Arkansas baseball 2028 class grows to 13 commits
With the addition of two more commits from Houston and one from Chicago, the Razorbacks' class includes players from eight states.
Vikings Coach Explains Why Offense Is Taking Different Approach
Minnesota Vikings head coach Kevin O’Connell went on the Pat McAfee Show and discussed a variety of things. From discussing injuries to key players, including Justin Jefferson, to strategy, it was a wide-ranging interview. One particular nugget revealed a bit of his offensive strategy.The Vikings have had a roller-coaster offensive attack. Sunday’s win against the […] The post Vikings Coach Explains Why Offense Is Taking Different Approach appeared first on HEAVY.
Order of the Sinking Star: Jonathan Blow on making ' the biggest puzzle game ever'
Order of the Sinking Star is due out on Thursday and has roughly 1,500 puzzles for players to try
Spurs believe Dylan Harper is their second-best player?
Spurs believe Dylan Harper is their second-best player?
The Jets should change their running back approach
Over the last couple of years, one thing that has frustrated me with the Jets’ approach to offense has been their insistence on using Breece Hall as a do it all back. Hall is a very talented player, but I think it’s clear that he isn’t a complete back. He is an explosive play threat […]
Forza Horizon 6's Community Is Fed Up With Playground Games, and the Studio Has Finally Responded
Forza Horizon 6 developer Playground Games has finally addressed its player community after months of constructive feedback about the game has been met with nothing but radio silence from the renowned British studio.
Is Mike McCarthy's snap-count analytics benching Steelers playmakers?
Former Pittsburgh Steelers players critique head coach Mike McCarthy for using strict snap-count analytics to bench top playmakers.
Auburn Basketball Faces Key Early Tests
Auburn basketball's opening games will serve as an early indicator of just how good this team can be. As players become more familiar with their roles, Auburn will have the chance to build confidence and team identity while also finding ways to grow. Even though early results do not matter as much as conference play, …
Ronald Waterreus Defends Matej Kovar Amid 'Unfair' PSV Criticism
Former PSV player Waterreus tackles the harsh scrutiny surrounding the Czech keeper, highlighting a crucial Harry Kane save while questioning if tactical demands lead to his perceived errors.
Gears of War: E-Day - Surviving the First Night of Emergence
Today marks the worldwide launch of Gears of War: E-Day, now available on XBOX Series X|S, XBOX on PC, Game Pass and Steam. One of XBOX’s most iconic sagas returns to where it all began, taking players back to the opening hours of Emergence Day and the catastrophic event that changed the world of Sera […]
Matt LaFleur Puts Packers on Notice After Week 4 Turnovers
Following a sloppy victory over the Tampa Bay Buccaneers, the Green Bay Packers' head coach threatened to bench players who fumble the football.
Every Wisconsin player drafted by the Boston Celtics
Let's take a look at every player who has been drafted by the Celtics out of Wisconsin.
How West Michigan’s power players earned their first paychecks
Before they led companies and institutions, the Who's Who washed dishes, delivered newspapers, picked blueberries and flipped burgers.
McClean hits out at 'incomprehensible' Derry treatment
Derry City player James McClean hits out at his treatment by Derry City amid an ongoing contract dispute with the club.
Northwestern Linebacker Named Big Ten Defensive Player of the Week
Northwestern captain Braydon Brus earned Big Ten Defensive Player of the Week honors after recording nine tackles, a sack and his first career interception in the Wildcats’ 34-13 win over Penn State.
8 Players Withdraw from ATP Shanghai
Shanghai, the penultimate Masters 1000 of the year has, in recent years, been one of the most unpredictable. Several withdrawals are already contributing to the narrative of the tournament as it’s set to get underway soon. Which Players Have Withdrawn from Shanghai? Jannik Sinner has once again pushed back his return to the court, withdrawing …
ALDS Game 2 Player of the Game: Ben Rice
Rice's two homers provided the only resistance the Yankees could muster in another ugly playoff loss.
Scanning offers players like Martin Odegaard an edge as football becomes faster and more intense
Sky Sports Nick Wright tried out virtual reality technology designed to train scanning to see how some players are improving their off-the-ball awareness; Martin Odegaard, Aurelien Tchouameni, Marc Guehi and Romeo Lavia are among those to have used it
"Honestly..." Former Feyenoord Player Opens Up On Ajax This Season
Alireza Jahanbakhsh has shared his thoughts on Ajax after the Amsterdammers drew 2-2 against Excelsior.
Star Wars: Galactic Racer launches on Amazon Luna as part of Prime subscription
"Luna players can jump into the single-player campaign the moment it launches without needing to own a console or wait for a lengthy download"
Meditation is ideal for baseball’s grind. Why do many players remain skeptical?
Even as players embrace once-radical ideas, the concept of meditation can still clash with the culture of the sport.
Three French prospects make final Golden Boy shortlist
Three French players have been included on the final 25-player shortlist for the Golden Boy, an award created by Italian media Tuttosport to recognise the best talents under the age of 21 plying their...
De Roon to start alongside Kone vs Como
Roma returns to training today ahead of the trip to Como, scheduled for Sunday at 12:30. Gian Piero Gasperini will gradually reunite all the players who have been on international duty in recent weeks...
NBA 2K25 servers to shut down on December 31, single-player story mode will become unplayable
Decision to sunset 2K25 follows 2K's trajectory of delisting NBA games over the course of two years
Which Premier League players got injured during the international break?
The current international break has stretched well beyond what fans are used to.But the three-week break is set to end now, as football enthusiasts eagerly wait for the Premier League action to resume...
Two Overlooked Stars Keeping Packers Alive
The 2026 Green Bay Packers look and feel like a bad team that has miraculously beaten even worse teams. The coaching and scheme have not consistently aligned with the players’ abilities to execute, while gut-wrenching injuries have left Green Bay relying on backups across multiple position groups. And it is only Week 5. For a …
Fantasy football IDP free-agent report: Week 5
This is our weekly Waiver Wire feature depicting the best individual defensive players to target on waivers in fantasy.
Four Lakers players will miss Monday's preseason opener
The Lakers will be without four players when they open their 2026-27 preseason schedule on Monday.
Every Wyoming player drafted by the Golden State Warriors
Let's take a look at every player who has been drafted by the Warriors out of Wyoming.
Keldon Johnson Makes Ruling on Spurs' Starting Lineup Situation
The San Antonio Spurs have more than enough options for the starting lineup, which means some players will feel snubbed. Keldon Johnson explained why he doesn't care what his teammates think.
Why 76ers' New Superteam Is Different From Daryl Morey’s
In the past, the 76ers struggled to find the right combination of players to get over the hump. But now they have, or so they think.
Hawkeye Women Land Athletic Center Khalia Hartwell From 2027 Class
Fans of Iowa women’s hoops should be very excited about some of the recruits that are saying yes to the black and gold in the post Caitlin Clark era. Jan Jensen has had some of the very best high school players expressing serious interest in Iowa and has convinced a few of them to commit. […]
Tony Gilroy on Leaving the Politics of 'Andor' Behind for His 9-Composer Music Drama 'Behemoth!'
NEW YORK (AP) — Long before Tony Gilroy wrote “The Bourne Identity," made “Michael Clayton” or created “Andor,” he wanted to be a musician. After playing guitar in a string of bands, Gilroy came to Los Angeles hoping to become a studio musician. A session with some real players quickly disabused him ...
The Resurrection of Gio Reyna
Once a promising prodigy, 23-year-old Gio Reyna has turned a turbulent USMNT career marked by controversy into an opportunity for mentorship. No player has benefited more from the start of the 2030 cy...
NBA Scout Calls Jalen Duren an Overpaid Role Player
An anonymous NBA scout had a blunt verdict on what Detroit just paid Jalen Duren. #Pistons
Clemens' McKenna Gobin selected E-N volleyball Player of the Week
Clemens senior McKenna Gobin selected Express-News volleyball Player of the Week.
Bills player dismisses Patriots hero as ‘practice squad player’
After a 0-3 start to the season, the New England Patriots were able to bounce back in a big way on Sunday afternoon, pulling off an upset win over the Buffalo Bills on the road after Patriots wide receiver Efton Chism III made a ridiculous catch to give the Patriots the lead with under two…
CD Projekt Promises 'The Witcher 3' Remaster Fixes as Some Players Struggle
An upcoming patch will target performance issues
NBA Trade Idea Sends Mavericks Player, Hawks Player to Pacers
This NBA trade idea sends a Dallas Mavericks player and an Atlanta Hawks player to the Indiana Pacers.
Kings HC Christie 'Really Enjoying' FA Signing Simmons
The Sacramento Kings are hoping free agent pickup Ben Simmons can get back to a semblance of his old self, while giving the team a much-needed boost on the defensive end. Head coach Doug Christie has been extremely positive regarding Simmons, calling him a "special" player.
How a 'superwoman' who plays pro tackle football has built a flag football powerhouse
During the fall, Rachel Karos coaches Willowbrook flag football. Come spring, she is a professional tackle football player in the WNFC.
NBA 2K25 Is Getting Delisted After Just 2 Years, and Single Player Story Mode Will Become Unplayable
NBA 2K25 is being delisted after just two years, and players will soon no longer be able to play the game's single player story mode.
Barcelona superstar set for salary raise as per prior agreement
Lamine Yamal’s start to the new season has been astonishing, and the player is operating at a level that any normal teenager should not even be able to dream of.He is, at this point, one of the best...
2026-27 MLS NEXT schedule: Key dates to know
By MLSsoccer staffThe 2026-27 MLS NEXT season will be the seventh and largest in league history, expanding national competition and player development opportunities across North America's top youth so...
Every William & Mary player drafted by the Boston Celtics
Let's take a look at every player who has been drafted by the Celtics out of William & Mary.
Chelsea is leading Arsenal in the race for England international
New England star Alex Scott is one of the most sought-after players in European football, and Arsenal wants to add him to its squad.The Bournemouth midfielder has established himself as an outstanding...
PFF ranks Michigan State's top five offensive players vs. Wisconsin
Check out who PFF ranked as Michigan State's top five offensive players against Wisconsin.
AI game mashup videos on social media spark debate and backlash among players and modders
The Claude-created videos overlay one game on top of another to make a rudimentary ‘mashup’…
Millions return to The Witcher 3 as the Remastered game records another Steam personal best and sales skyrocket
CD Projekt Red's overhaul of The Witcher 3 is pulling players back in their millions, while also attracting plenty of new ones.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
NBA 2K25 is being delisted later this month, servers (including single-player story mode) shut down at the end of the year
MyCareer, MyTeam and all other online game modes will end in December…
Michigan's largest banks after the Fifth Third-Comerica deal
Consolidation continues to shift the list of the largest players in Michigan's banking industry.
Experienced signings will help captain James
Cesar Azpilicueta backs Chelsea's decision to sign experienced players this summer and believes it will help captain Reece James grow as a leader.
Penguins Linked To $92.8 Million Star Forward
The discussion that fans of the Pittsburgh Penguins know is coming at some point is at least a full season away, but they won’t be able to ignore it much longer.The iconic duo of Sidney Crosby and Evgeni Malkin aren’t getting any younger, and both players are going to call it a career sooner rather […] The post Penguins Linked To $92.8 Million Star Forward appeared first on HEAVY.
Ageless Novak Djokovic Stays Perfect in Beijing
Age is supposed to slow a tennis player down. Nobody has told Novak Djokovic. At 39, the Serb eliminated world No. 2 Alexander Zverev in the China Open quarterfinals and extended a streak in Beijing with no Open Era precedent. Djokovic is now 32-0 at the tournament. No player in the Open Era has won …
Where These Three Knicks Stand in Contract Extension Negotiations
As the season approaches, the Knicks have three players they may extend soon.
3 Most Disappointing Cubs Players In 2026
From high-priced free agents to a botched blockbuster trade, these three struggling stars derailed Chicago's championship aspirations and fueled a premature postseason exit against the Padres.
Ace Combat 8: Wings Of Theve Smashes Series Steam Record With Over 52,000 Concurrent Players
Ace Combat 8: Wings of Theve is off to the series' best PC launch by a wide margin. The game came out on October 2 and peaked at over 52,000 concurrent Steam players a day later, according to SteamDB. That is nearly four times the 13,758 that Ace Combat 7: Skies Unknown managed in 2019, while...
Exploring Corey Seager's Rollercoaster Season
Texas Rangers shortstop Corey Seager had an arduous 2026 season, but he still demonstrated the type of player he can be.
Registered Players Of Rare Cookie's Bustle Invited To Secret Party
After being freed from a patent troll earlier this year, the infamous '90s adventure game Cookie's Bustle is renewing the enigma that is itself
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The Los Angeles Chargers suffered a major blow as this key player was ruled inactive.
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Week 4 inactives for Rams
Los Angeles declares seven players inactive versus Philadelphia
New England Nation: Inside the Locker Room
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