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Results for " DEATH " 2,222 found 🔀 AI-powered Shuffle

Family's Eccleshall pride as superbike winner Storm Stacey spreads mental health message

Storm Stacey uses a top hat to start conversations about mental health, after his father's death.

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Jul 7 • 1:13 AM EDT • Health • bbc.com
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Xbox sale round-up July 7, 2026

New Xbox sales are now live, with big discounts on Atomic Heart, Dragon Ball FighterZ, DEATHLOOP, Dead Cells, Redfall, Dragon Ball Xenoverse 2, Naruto Shippuden: Ultimate Ninja Storm 4 and more

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Jul 6 • 8:10 PM EDT • Technology • trueachievements.com
Capital Region influencers support Muslim-owned businesses in light of hate

LATHAM, N.Y. (NEWS10) — In light of recent online hate, local community members have been banding together, using their platforms to support one another following the death of seven-year-old …

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Jul 6 • 5:45 PM EDT • Business • news10.com
Why Kelly Reilly thinks Monica’s ‘Marshals’ death was a ‘missed opportunity’ in ‘Dutton Ranch’ season 1

Kelly Reilly is sharing why she thinks Monica’s death on fellow ‘Yellowstone’ spinoff ‘Marshals’ was a real ‘missed opportunity’ in season 1 of her and Cole Hauser’s ‘Dutton Ranch.’

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Jul 6 • 3:44 PM EDT • Entertainment • ew.com
Ebola deaths in Congo top 500 as health workers threaten to strike

The outbreak has recorded 1,561 cases, including 506 deaths, since it was declared on May 15 as the spread continues to outpace response, Congo's Ministry of Health said in its latest update on Sunday night.

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Jul 6 • 12:28 PM EDT • Health • latimes.com
Ebola deaths in Congo top 500 as frontline health workers threaten to strike

Health professionals demand payment and better conditions, citing inadequate supplies and poor salaries.

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Jul 6 • 12:11 PM EDT • Health • pbs.org
Ebola deaths in Congo top 500 as health workers threaten to strike

Frontline workers have threatened to strike over unpaid benefits and poor working conditions.

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Jul 6 • 10:26 AM EDT • Health • bostonherald.com
Courts, citizenship and Alabama’s political test

This week’s "The Voice of Alabama Politics" examines citizenship, constitutional enforcement, death penalty clemency and voter turnout as Alabama’s political stakes sharpen in 2026.

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Jul 6 • 8:54 AM EDT • Politics • alreporter.com
Ebola deaths in Congo top 500 as health workers threaten to strike

Authorities report that at least 500 people have died from over 1,500 confirmed Ebola cases in Congo.

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Jul 6 • 8:53 AM EDT • Health • seattletimes.com
Ebola deaths in Congo top 500 as health workers threaten to strike

Authorities report that at least 500 people have died from over 1,500 confirmed Ebola cases in Congo

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Jul 6 • 8:52 AM EDT • Health • abcnews.com
The Talos Principle 3 creators are doing their best to stay hopeful in the tech apocalypse

The puzzle series' final installment is staying optimistic, even in the face of death and AI

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Jul 6 • 8:00 AM EDT • Technology • polygon.com
Streetlights are trapping thousands of pill bugs in giant “death spirals”

Researchers discovered that artificial streetlights can trap thousands of woodlice in mesmerizing circular "death spirals" never before seen in the wild. The surprising finding suggests that light pollution may be unintentionally altering the behavior of even the smallest ground-dwelling animals.

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Jul 5 • 8:00 PM EDT • Science • sciencedaily.com
Metal Gear Creator Responds To Sony Killing PlayStation Discs

The Death Stranding 2 director warns about a world without physical media

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Jul 5 • 10:18 AM EDT • Technology • kotaku.com
Scientists may have finally found how Alzheimer's kills brain cells

Researchers have identified a previously overlooked mechanism of brain cell death that appears to play a major role in Alzheimer's disease and frontotemporal dementia. The finding could lead to new treatments aimed at slowing neuron loss by interrupting the process before cells are destroyed.

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Jul 5 • 8:00 AM EDT • Science • sciencedaily.com
Science & Medicine: Training health care workers to save lives in Texas maternity care deserts

In the nearly half of Texas counties considered maternity care deserts, few health care workers are trained to handle a pregnancy emergency like maternal cardiac arrest. A simulation-based training program from an expert at UT San Antonio's Kate Marmion School of Public Health aims to change that, and reduce preventable deaths in the process.

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Jul 5 • 7:00 AM EDT • Science • tpr.org
Science & Medicine: Training health care workers to save lives in Texas maternity care deserts

In the nearly half of Texas counties considered maternity care deserts, few health care workers are trained to handle a pregnancy emergency like maternal cardiac arrest. A simulation-based training program from an expert at UT San Antonio's Kate Marmion School of Public Health aims to change that, and reduce preventable deaths in the process.

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Jul 5 • 7:00 AM EDT • Health • tpr.org
Hideo Kojima ‘really sad’ about PlayStation killing discs, ‘frightened’ for future of ownership

The Death Stranding director has reacted to PlayStation going all-digital…

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Jul 5 • 6:30 AM EDT • Technology • videogameschronicle.com
Kojima Mourns the Death of PlayStation Discs in 2028, but Warns Cloud Gaming Is the Real Nightmare Ahead

Kojima laments the end of PlayStation discs in 2028 and warns that cloud gaming could be an even bigger threat to the future of game ownership

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Jul 5 • 5:00 AM EDT • Technology • wccftech.com
19 suspected heat-related deaths since dangerous heatwave began, N.J. health official says

Most of the deaths have involved people found in homes without air conditioning, said a state official.

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Jul 4 • 2:36 PM EDT • Health • nj.com
The Steam Machine Has Its Own ‘Red Ring Of Death’

History doesn’t always repeat itself, but it often rhymes, as one Steam Machine owner discovered a familiar fatal error alert

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Jul 4 • 12:30 PM EDT • Technology • kotaku.com
Deaths surged 29% in France during week of record heat, health agency says

France experienced a surge in deaths during the hottest week of a record heat wave last month.

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Jul 3 • 3:36 PM EDT • Health • seattletimes.com
Young humpback whale freed from a death trap in Alaska

The whale was entangled in crab pot lines at Endicott Arm near Juneau.

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Jul 3 • 12:30 PM EDT • Science • popsci.com
Kelly Osbourne pays tribute to late father Ozzy with new tattoo

Kelly Osbourne is honoring her late rocker dad, Ozzy Osbourne, ahead of the one-year anniversary of his death with a new tattoo.

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Jul 3 • 10:51 AM EDT • Entertainment • ew.com
'Dutton Ranch's Natalie Alyn Lind talks finale's 'heartbreaking' death

Spoiler alert!

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Jul 3 • 10:25 AM EDT • Entertainment • centraloregondaily.com
Deaths surged 29% in France during week of record heat, health agency says

Deaths surged in France during the hottest week of a record heat wave last month, the country’s public health authority said Friday.

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Jul 3 • 9:18 AM EDT • Health • wbaltv.com
The end of an era: New report points to the death of OnePlus' Oxygen OS

A new report claims OPPO will discontinue Oxygen OS and realme UI on future OnePlus and realme devices globally, in favor of Color OS.

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Jul 3 • 8:20 AM EDT • Technology • androidauthority.com
Heat wave in France saw 2,000 more deaths, says public health authority

France experienced a surge in deaths during the hottest week of a record heat wave last month. Public Health France said it recorded at least 2,000 more deaths than the previous week.

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Jul 3 • 8:07 AM EDT • Health • apnews.com
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Early Steam Machine user mourns "red line of death" following GPU failure

"Pretty cool for the 20 minutes that it worked".

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Jul 3 • 5:57 AM EDT • Technology • digitalfoundry.net
Liverpool install new Jota memorial

Liverpool have installed a permanent memorial outside Anfield in tribute to Diogo Jota and his brother Andre Silva to mark the first anniversary of their death. The 'Forever 20' memorial, created by renowned sculptor Emma Rodgers, is centrally a flowing heart sculpture, an acknowledgement of the forward's goal celebration. From different angles it also shows the numbers 20 and 30, the brothers' shirt numbers, and includes the lyrics to Jota's song, which has been sung in the 20th minute of every match since his death in a car crash on 3 July 2025.

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Jul 3 • 4:21 AM EDT • Sports • sports.yahoo.com
Health forum gives East Texans steps to prevent heart disease death

Nearly 700,000 people in the U.S. died of heart disease in 2023, but experts say many cardiovascular problems are preventable.

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Jul 2 • 9:18 PM EDT • Health • kltv.com
Rams announce death of franchise great LeRoy Irvin

Irvin is one of a handful of players to make All-Pro at multiple positions

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Jul 2 • 3:56 PM EDT • Sports • sports.yahoo.com
U.S. death rate fell to lowest level on record in 2025, CDC says

The rate of deaths fell for all age groups compared with 2024, according to preliminary data.

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Jul 2 • 12:14 PM EDT • Health • spectrumlocalnews.com
Heat wave caused some 480 excess deaths in Netherlands, health authorities say

Last week's unprecedented heat wave led to around ​480 excess deaths in ‌the Netherlands, Dutch health authorities said on Thursday.

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Jul 2 • 10:32 AM EDT • Health • reuters.com
Heat Wave Caused Some 480 Excess Deaths in Netherlands, Health Authorities Say

AMSTERDAM, July 2 (Reuters) - ⁠Last ⁠week's unprecedented ⁠heat wave led to around 480 excess deaths in ‌the Netherlands, Dutch health ‌authorities said ⁠on ⁠Thursday. • Excess deaths in the week from June 22 to 28 were mainly among people aged 80 years and older. • Most ⁠were reported ⁠in the ...

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Jul 2 • 10:32 AM EDT • Health • usnews.com
The Earth Will Not Be Consumed When The Sun Becomes A Red Giant, But Life Will Die Out By 1.8 Billion Years Anyway

Researchers revisited both the Sun's eventual death and the lifespan of Earth's biosphere, and neither result was quite what they were expecting.

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Jul 2 • 9:27 AM EDT • Science • iflscience.com
9 Founders Who Turned Their Worst Moment Into A Business

Nine founders faced rock bottom, a death, a diagnosis, a war, a collapse, and built a business out of it. How they found strength when it felt furthest away.

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Jul 2 • 8:00 AM EDT • Business • forbes.com
James Ransone coroner report shows actor's mental health struggles

"The Wire" actor James Ransone wanted mental health treatment before his death by suicide at 46, according to a medical examiner's report.

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Jul 1 • 10:04 PM EDT • Health • usatoday.com
New details about 'The Wire' actor James Ransone's death revealed

New information about the death of 'The Wire' actor James Ransone was revealed in a report from the County of Los Angeles Medical Examiner's office.

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Jul 1 • 9:44 PM EDT • Entertainment • ew.com
CHAMP Initiative Combines Climate Science and Storytelling to Address Urban Heat

As summer temperatures climb, so does the risk of extreme heat—now recognized by the National Oceanic and Atmospheric Administration as the leading cause of weather-related deaths in the United States. In cities such as Camden, where buildings, pavement, and other infrastructure trap heat and create higher temperatures than surrounding areas, understanding the impacts of urban […]

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Jul 1 • 2:55 PM EDT • Science • sebsnjaesnews.rutgers.edu
Victor Willis, who co-founded the Village People and co-wrote 'Y.M.C.A.,' dies

The group announced his death on Facebook, citing "a short but aggressive illness"

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Jul 1 • 1:00 PM EDT • Entertainment • spectrumlocalnews.com
Victor Willis, who co-founded the Village People and co-wrote 'Y.M.C.A.,' dies

The group announced his death on Facebook, citing "a short but aggressive illness"

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Jul 1 • 1:00 PM EDT • Entertainment • spectrumlocalnews.com
Victor Willis, who co-founded the Village People and co-wrote 'Y.M.C.A.,' dies

The group announced his death on Facebook, citing "a short but aggressive illness"

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Jul 1 • 1:00 PM EDT • Entertainment • spectrumlocalnews.com
Cause of death revealed for Oregon-raised star of 'The Ring,' 'Lilo & Stitch'

Daveigh Chase, the Oregon-raised actress known for her roles in the films like "Spirited Away," “Lilo & Stitch” and “The Ring," died June 16 from complications due to AIDS, The Oregonian reports.

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Jul 1 • 11:39 AM EDT • Entertainment • centraloregondaily.com
NASA’s Webb Studies How Planet Survived Death of its Star

NASA’s James Webb Space Telescope is giving us new insight into the far-future of solar systems like our own, as the agency continues to reveal the secrets of

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Jul 1 • 11:00 AM EDT • Science • science.nasa.gov
Brother of Calais Campbell charged with murder after mother's death
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Jul 1 • 8:32 AM EDT • Sports • sports.yahoo.com
Hospital sued after drug addict nurse allegedly causes death of two patients

An emergency department nurse at Heritage Valley Sewickley Hospital is accused of stealing drugs and neglecting patients, causing at least two fatalities. A lawsuit filed by two whistleblowers further alleges that hospital leadership covered for the drug-dependent nurse.

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Jul 1 • 1:12 AM EDT • Health • healthexec.com
Can GLP-1 medications improve health in people with Type 2 diabetes and PAD?

Research Highlights: GLP-1RA (glucagon-like peptide-1 receptor agonist) medications, which are prescribed to treat Type 2 diabetes and to help with weight loss, were found to reduce the number of deaths, amputations and hospitalizations among people...

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Jun 30 • 8:00 PM EDT • Health • newsroom.heart.org
Western Pa. nurse accused in lawsuit of causing 2 patient deaths, stealing drugs

A federal lawsuit accuses Heritage Valley Health System and staff members of enabling alleged crimes by emergency department nurse Nolan Chismire, including drug theft, false insurance claims, and failures in patient care allegedly linked to two deaths.

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Jun 30 • 5:22 PM EDT • Health • wtae.com
Taxes, Death, and Haaland scoring a goal 🇳🇴

Taxes, Death, and Haaland scoring a goal 🇳🇴

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Jun 30 • 4:25 PM EDT • Sports • foxsports.com
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Your Brain Doesn’t Just Turn Off When You Die. What Really Happens Defies Our Understanding of Reality.

Some scientists suggest that there’s an in-between state that divides life and death.

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Jun 30 • 12:19 PM EDT • Science • popularmechanics.com
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Press Release- Rowan County Sees Increase in Overdose Emergency Department Visits 2026

Rowan County Sees Increase in Overdose Emergency Department Visits; Ranks Second Highest in North Carolina for Fentanyl-Positive Death RateSalisbury, NC – Rowan County health officials are raisin

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Jun 30 • 10:35 AM EDT • Health • rowancountync.gov
Disney star’s dad reacts to daughter’s heartbreaking death from AIDS
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Jun 30 • 10:35 AM EDT • Entertainment • nj.com
What are the Numbers for Ideal Heart Health?

Heart disease remains the leading cause of death in the United States so Dr. Roshini Raj, associate professor at NYU Langone Health, joins TODAY with a look at the five categories, and the ideal numbers for each, linked to optimal heart health.

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Jun 30 • 9:41 AM EDT • Health • today.com
'Lilo & Stitch' star Daveigh Chase's father reacts to daughter's death from AIDS at 35

'Lilo & Stitch' and 'The Ring' actress Daveigh Chase's father offered a heartbreaking reaction to his daughter's death after the medical examiner's office ruled her cause of death to be AIDS.

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Jun 30 • 9:00 AM EDT • Entertainment • ew.com
DEATH OF SYSTEM FOOTBALL | OPEN THREAD

Welcome to The Daily Merengue! THESE ARE YOUR MODS: Ezek XI, Valyrian Steel, KungFuZizou, NeRObutBlanco, Felipejack, and Juninho LEAST TALENTED This is the least talented generation of footballers we’re seeing world wide. Due to the lack of generational players, teams have adopted what they hope to be a generational system. Generational players are much harder […]

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Jun 29 • 11:26 PM EDT • Sports • sports.yahoo.com
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Morgan Fairchild 'knew what it was' when Rock Hudson got sick with AIDS: 'Everybody in Hollywood knew Rock was gay'

Morgan Fairchild looks back on the death of actor Rock Hudson and reveals she 'knew what it was' when he got sick with AIDS in 1984: 'Everybody in Hollywood knew Rock was gay.'

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Jun 29 • 11:26 PM EDT • Entertainment • ew.com
Chiefs Honor Former Running Back Joe Delaney on Death Anniversary

Kansas City missed the playoffs for the first time in the Patrick Mahomes era last season, finishing 6-11. Before last season, Mahomes had led the Chiefs to at least the AFC championship game every year prior.

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Jun 29 • 4:31 PM EDT • Sports • sports.yahoo.com
'The Ring' actress Daveigh Chase's cause of death revealed

The cause of her death for 'Lilo & Stitch' star Daveigh Chase has been revealed.

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Jun 29 • 1:51 PM EDT • Entertainment • ew.com
'The Ring' star Daveigh Chase's cause of death revealed

Daveigh Chase's official cause of death has been released. The "Lilo & Stitch" and "The Ring" actress died from AIDS, according to Los Angeles medical examiner online records viewed by

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Jun 29 • 10:48 AM EDT • Entertainment • centraloregondaily.com
Union Pacific And Norfolk Southern: How Politics Can Have A Body Count

Advances in goods shipment must be achieved not to bring harm to the trucking industry, but to protect increasingly acquisitive Americans from death born of their wealth.

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Jun 29 • 10:00 AM EDT • Politics • forbes.com
France Recorded 1,000 Excess Deaths During Heat Wave, Officials Say

First estimates published by the national health agency listed hundreds more deaths per day compared with the daily death rate in previous months.

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Jun 29 • 7:33 AM EDT • Health • nytimes.com
America's lifespan has doubled since 1776

U.S. life expectancy has doubled since 1776 thanks to vaccines, antibiotics, sanitation and clean water that reduced infectious disease deaths.

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Jun 28 • 11:52 PM EDT • Health • foxnews.com
The Siege of Death Mire

Imperial Victory! New Warhammer 40,000 miniatures revealed!

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Jun 28 • 8:00 PM EDT • Technology • warhammer-community.com
Vallejo: Armed Suspect Arrested After Allegedly Making Death Threats At Business

Police have arrested a man after he allegedly brandished a gun and made death threats to customers at a business in Vallejo, police said Sunday.

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Jun 28 • 5:39 PM EDT • Business • sfgate.com
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial

Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to

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Jun 28 • 3:45 PM EDT • Health • astrazeneca-us.com
'The fate of Earth depends on a delicate balance': Our planet may survive the death of the sun after all, new models hint

When the sun dies, it will become hundreds of times its current size and engulf the innermost planets. Earth may escape this infernal fate, according to state-of-the-art stellar evolution models.

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Jun 28 • 10:00 AM EDT • Science • livescience.com
GTA 6 could be the final death knell for physical media

But you can always collect empty boxes.

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Jun 28 • 3:00 AM EDT • Technology • creativebloq.com
Chicago faith leaders, businesses rally to collect supplies for Venezuela earthquake victims

In Chicago, pastors and businesses across the city are coordinating efforts to send aid after devastating earthquakes in Venezuela.

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Jun 27 • 4:13 PM EDT • Business • nbcchicago.com
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Scientists finally reveal the shocking truth behind England’s dolphin deaths - Futura-Sciences

A Drastic Decline Along English Shores The dolphin populations along the English coastline have been disappearing at an alarming rate for several decades. Contrary to what many might hope, these aren’t dolphins simply seeking warmer waters elsewhere. The brutal reality is that this is not migration—it’s mass mortality. English researchers...

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Jun 27 • 10:30 AM EDT • Science • futura-sciences.com
The Pressure On Bungie’s ‘Marathon’ After Destiny 2’s Death Is Insurmountable

Marathon was never supposed to be here, but now is tasked with ensuring Bungie survives as a studio now that Destiny 2 is dead.

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Jun 27 • 9:52 AM EDT • Technology • forbes.com
‘Faces Of Death’ To Close Edinburgh’s Midnight Madness Strand

'Faces Of Death' will be the closing title of Edinburgh’s Midnight Madness strand.

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Jun 26 • 9:00 AM EDT • Entertainment • deadline.com
Europe’s Deadly Heat Wave: A Jolt for Climate Action, or Just for A.C.?

Heat-related deaths and disruptions to daily life are forcing politicians to reckon, in different ways, with a rapidly warming planet.

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Jun 26 • 6:02 AM EDT • Politics • nytimes.com
'It's business': 2027 5-star CB on choosing Texas over Texas A&M

2027 5-star CB John Meredith "loves A&M to death" but made a reported business decision in choosing the Texas Longhorns.

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Jun 26 • 5:09 AM EDT • Business • sports.yahoo.com
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Ex-NFL player Doug Martin's family sue Oakland police, allege restraint asphyxia in fatal mental health crisis

Parents of former NFL running back Doug Martin file wrongful death lawsuit alleging he died from restraint asphyxia caused by Oakland police.

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Jun 25 • 6:22 PM EDT • Health • foxnews.com
FlashPoint: How a Christian political media network became a platform for Indiana’s Lt. Gov.

By Sydney Byerly The Indiana Citizen June 25, 2026 When Indiana Lt. Gov. Micah Beckwith called Islam a “demonic death cult” during an appearance on the Christian political program FlashPoint in May, the remarks drew swift backlash from faith leaders across Indiana. It also highlighted the growing influence of the Christian media network that amplified

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Jun 25 • 5:18 PM EDT • Politics • indianacitizen.org
Making Our Own Luck

We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.

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Jun 25 • 4:48 PM EDT • Science • goodscience.substack.com
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Jun 24 • 11:04 AM EDT • Entertainment • centraloregondaily.com
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Jun 24 • 11:00 AM EDT • Science • popsci.com
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Jun 24 • 8:00 AM EDT • Science • sciencedaily.com
Death Row Disability Cases Are Questions of Morality, Not Science

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Jun 24 • 4:30 AM EDT • Science • news.bloomberglaw.com
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Jun 24 • 12:01 AM EDT • Health • nbcnews.com
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Jun 23 • 6:56 PM EDT • Politics • spectrumlocalnews.com
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Jun 23 • 1:00 PM EDT • Technology • news.blizzard.com
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Jun 23 • 12:17 PM EDT • Entertainment • huffpost.com
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Jun 23 • 12:00 PM EDT • Science • theguardian.com
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Jun 23 • 9:50 AM EDT • Science • cnn.com
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Jun 23 • 5:00 AM EDT • Health • cnn.com
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Jun 23 • 2:33 AM EDT • Business • radiologybusiness.com
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Jun 22 • 4:33 PM EDT • Entertainment • yahoo.com
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Jun 22 • 12:15 PM EDT • Entertainment • spectrumnews1.com
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Jun 22 • 12:15 PM EDT • Entertainment • mynews13.com
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Jun 22 • 12:15 PM EDT • Entertainment • spectrumlocalnews.com
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Jun 22 • 11:02 AM EDT • Entertainment • fox5atlanta.com