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Ocasio-Cortez faces a crossroads in politics
Rep. Alexandria Ocasio-Cortez (D-N.Y.) is at a career and life crossroads that many women face at the age of 36, even without the pressure of a potential White House run. The congresswoman, still l…
Darline Graham faces battle for her brother's seat in South Carolina senate primary
Republican voters in South Carolina return to the polls Tuesday for the second time in two months to decide who will take the place of the late Sen. Lindsey Graham.
Wisconsin weighs a democratic socialist governor and other key races to watch in Tuesday’s primaries
The next battles over the Democratic Party’s ideological direction come Tuesday in a slate of primaries that includes showdowns in two upper Midwestern political battlegrounds.
Lallemand Bio-Ingredients to spotlight science-driven ingredients at Vitafoods Asia 2026
Lallemand Bio-Ingredients, Health Ingredients, a global leader in fermented functional ingredients for human health and nutrition, will showcase its latest science-backed ingredients at Vitafoods Asia 2026, taking place September 2-4, 2026, in Bangkok, Thailand
Azerbaijan: Health of imprisoned government critics at risk as another political activist faces extradition threat
The Azerbaijani authorities must ensure that Ali Karimli, Alasgar Mammadli and all other prisoners have immediate access to adequate drinking water, ventilation and all necessary medical care. Ukraine must fulfil its human rights obligations and not extradite Bahruz Hasanli to Azerbaijan.
Azerbaijan: Health of imprisoned government critics at risk as another political activist faces extradition threat
The Azerbaijani authorities must ensure that Ali Karimli, Alasgar Mammadli and all other prisoners have immediate access to adequate drinking water, ventilation and all necessary medical care. Ukraine must fulfil its human rights obligations and not extradite Bahruz Hasanli to Azerbaijan.
Arsenal agree deal with Crystal Palace youngster
Crystal Palace youngster Mylo Bernard has agreed to join Arsenal, with the Gunners reportedly only needing to pay a training compensation payment.Photo via Bernard on InstagramJames McNicholas reports...
Health Sciences outreach program helps amplify the voices of people with aphasia
The UK College of Health Sciences is helping people with aphasia reconnect with their communities by partnering with local businesses and organizations to create more communication-friendly spaces. Through a unique outreach program, students work alongside individuals with aphasia to educate employees, reduce communication barriers and make everyday experiences more accessible and welcoming.
Candeeland Indoor Playground set to bring new family entertainment option to Valley Mall
EL CENTRO — Families in the Imperial Valley will soon have a new place for children to play, explore, and spend time together as Candeeland prepares to open an approximately
Curiosity Blog, Sols 4968-4974: Rock Climbing Towards the Discontinuity
Written by Lucy Lim, Planetary Scientist at NASA’s Goddard Space Flight Center
East Bay congressional race to replace Eric Swalwell heats up between Aisha Wahab, Melissa Hernandez
Voters in the East Bay have about a week to decide who will fill the remainder of former Rep. Eric Swalwell's congressional term in a special election that has become an expensive and increasingly contentious contest between two Democrats. BART Board President Melissa Hernandez and state Sen. Aisha Wahab are facing off in the race.
Big Bear bald eagle Jackie dies after lingering health issues
Connecticut Democrats weigh generational change as US. Rep. John Larson, 78, faces primary fight
Connecticut Democrats face a choice between U.S. Rep. John Larson and younger challengers for the 1st Congressional District
Psychopathic Tendencies Are Linked to Microbes Inside Your Body, Study Reveals
It’s not just you.
Chiefs’ Andy Reid Gets Honest About Rams Amid ‘Rare’ Situation
This could be one of three matchups this season. The post Chiefs’ Andy Reid Gets Honest About Rams Amid ‘Rare’ Situation appeared first on HEAVY.
Surprising Lions linebacker Building Legitimate 53-Man Roster Case
The Detroit Lions added a bunch of new faces through free agency this offseason, including Joe Bachie. The veteran linebacker signed a one-year deal with the Lions after the draft in late April. Bachie spent the 2025 campaign in the AFC South, playing five games with the Colts before being placed on injured reserve with a foot injury and eventually being released with an injury settlement. Bachie landed on his feet with the Tennessee Titans but only served as a special teamer in Nashville.
A Fake Email Redirected $113,050 Into His Business Account, Then Nearly All the Money Was Gone in Hours
A North Dakota man is facing federal fraud charges after prosecutors say a nearly identical email address redirected $113,050 owed to an art dealer into ... Read More
Twelve U.S. Health Systems and Aidoc Unite to Confront America’s Diagnostic Capacity Crisis
As demand for diagnostic answers outpaces the physicians available to deliver them, health systems are collaborating with Aidoc on a shared goal: helping patients receive a safe, accurate diagnosis sooner.
Scientific advancement has never been more prolific—so why has trust in science plummeted?
From genome editing to quantum computing, scientific progress is accelerating at an unprecedented pace, yet public faith in science is collapsing. Our species has mapped the human genome, created powerful ...
Mayor throws weight behind delivery worker bill
The bill would eliminate the current contractor model and place the responsibility for worker safety.
Deadline passes for Rep. Max Miller to be replaced on Ohio ballot as he faces domestic abuse claims
Embattled Republican Rep. Max Miller is staying in the race for his Ohio congressional district
Opinion | Haims: Science is closing in on why we age
For nearly all of human history, aging has been accepted as something that simply happens. Bodies ware down, organs falter and the only reasonable response is to endure it with as much grace as one...
$100 GTA VI Ultimate Edition Surpasses Standard Edition in Pre-Orders
Grand Theft Auto VI is leading the charge in the $80 AAA race, which has understandably upset many gamers, but the $100 Ultimate Edition has been another point of contention in online discussions. However, despite the online discussions potentially suggesting otherwise, Take-Two CEO, Strauss...
Northwest Politics NOW: Aug 12, 2026
Reporting Portland and Vancouver area breaking news and weather stories to make Oregon and Southwest Washington a better place to live
Trump wades into data center debate amid political battle
{beacon} Technology Technology The Big Story Trump backs data centers as Texas sets new standards President Trump is touting the benefits of AI data centers after Texas mov…
Ars Live: Ross Scott discusses the Stop Killing Games movement
Our discussion takes place live on August 11 at 3 pm ET.
5 Laptops More Powerful Than The Xbox Series X
Some of the laptops that outperform an Xbox Series X include the MSI Thin 15, Acer Nitro V 16, Lenovo LOQ 15, Maingear Super 16, and Maingear Ultima 18.
'A little grace': Kate Beckinsale pushes back on comments about her weight loss
Kate Beckinsale pushed back on comments about her weight, opening up about grief, loss and a health condition.
U.S. Rep. Lauren Boebert’s son arrested, faces charges of sexual exploitation of minor
U.S. Rep. Lauren Boebert’s son Tyler Jay Boebert has been arrested and accused of recording and sharing a video depicting himself having intercourse with a minor, according to court records. The case originates in Garfield County in Western Colorado and was filed Thursday. Tyler Boebert, 21, is accused of five counts in total: three charges […]
Experts warn Oklahomans should expect health insurance costs to spike
As Oklahoma’s state employees face potential double-digit hikes in health insurance premiums, experts are warning that all Oklahomans should brace for a similar shock this year.
Sophie Cunningham reportedly shopping tell-all book amid WNBA controversy
Teaser: Indiana Fever guard Sophie Cunningham is reportedly shopping a tell-all book as her growing popularity and controversial public comments continue to place her in the WNBA spotlight.
Wisconsin’s Roller Coaster of a Democratic Primary Race for Governor Crashes to an End
Democrats appear likely to nominate a democratic socialist for governor. How did they get here?
Tennessee athletics sets fundraising record
University secures more than $175 million in donations in fiscal year 2026, breaking 2025 mark of $169.5 million
Dallas Hair Replacement for Business Professionals Offers Non-Surgical Hair Replacement for Men
Look Sharp, Stay Competitive. Restore your confidence with non-surgical hair replacement in Dallas.Dallas, TX, Aug. 10, 2026 (GLOBE NEWSWIRE) -- In the competitive business environment of Dallas, confidence and success go hand in hand. Whether you're presenting in the boardroom, networking at a conference, or closing a major deal, how you look plays a critical role in your self-esteem, which in turn affects how others perceive you. If you're a busy executive or professional experiencing hair los
Todd Blanche sworn in as attorney general after bruising confirmation battle
With the confirmation fight behind him, Blanche now faces the challenge of having to navigate the demands of a president who has made no secret his desire to use the law enforcement agency to target his political foes.
Saber's newest game trailer takes a shot at Gearbox's CEO, if you look closely
The first hint that something might be up with the recent debut trailer for Saber Interactive’s Rideshare Stimulator is an unusual choice of words—aside from that second one in the game’s title. “Don’t take your passengers too seriously,” the trailer’s narrator says, as he describes this upcoming game. It a car game about the gig work of driving eccentric people to their destinations, a riff on Crazy Taxi. And then, he says: “When I think I’ve met the randiest of passengers, someone even stranger gets in.” “Randiest”? That suggests “randy,” which usually means having strong sexual desire. Yet none of the oddball backseat occupants featured in the trailer seem particularly lustful. One is an old man who considers his grandson a failure, another shares the theory that birds might control traffic lights, another says he’s banned from an aquarium. A little later, there’s a license plate, shown 63 seconds into the trailer, on the front of an SUV: USB DRV It’s a Texas plate. The symbol between those letters is a cog wheel. If you know, you know. That’s a reference to Texas-based Borderlands game development studio Gearbox Software (their logo features a cog wheel). More specifically, it’s a reference to Gearbox’s CEO Randy Pitchford, who in 2018 found himself explaining the nature of video he’d saved on a USB drive that was found at a Medieval Times restaurant before being returned to the studio: “It was ‘barely legal’ porn. This girl’s handle was ‘Only 18.’” The “girl” in the video had committed a solo sex act that Pitchford, an avid practitioner of magic, found remarkable. “I realized, this is not a sex worker…This is a fucking magician.” Back then, the USB drive was central to competing lawsuits against Gearbox by the studio’s former lawyer and by Gearbox against him. A settlement in late 2019 “exonerated” Pitchford, per the Hollywood Reporter. The USB story has resurfaced at times, now in a trailer from a company that not long ago was corporate brethren with Gearbox. Saber vs. Gearbox The head of Saber told Game File that the reference is payback. “The dig is because Randy took shots at Embracer in Borderlands 4,” Saber CEO Matt Karch told me when I asked him about the license plate. “Without Embracer, Randy is performing magic tricks at birthday parties for a living.” Having interviewed Karch during a cross-country flight in late 2024, I can confirm that Karch was unimpressed with Pitchford during their time both working in the Embracer group. I’d approached him not out of surprise that there was animosity but that it was manifesting publicly now. Gearbox was founded in 1999, worked on a port of Halo early on, and developed hit series such as the loot-based sci-fi shooter Borderlands before it was purchased by The Embracer Group in early 2021 for $363 million (with a possible earn-out of over $1 billion, if certain targets were hit by 2027). Saber was founded in 2001, worked on a remaster of Halo early on, had a big hit with zombie shooter World War Z and was purchased by Embracer in early 2020 for $150 million, with a potential earn-out of up to $375 million. For a few years, the Embracer group was a voracious acquirer of game studios. Then, as investment dried up, it choked. In March 2024, Embracer sold Saber to an investment company controlled by Saber CEO Matt Karch, and it sold Gearbox in an all-stock deal to long-time Borderlands publisher Take Two Interactive. Other studios were shut down. Hundreds of developers were laid off. Gearbox didn’t say much about their Embracer experience, nothing too direct, at least. In the summer 2024, Pitchford told reporter and occasional Game File contributor Nicole Carpenter that Borderlands 4’s story was in some way thematically connected to Gearbox’s experience at Embracer: “There’s this cultural and emotional shift in me, personally, and at the studio. What does it mean to trade some autonomy for organization?” When Borderlands 4 came out, there was something stranger: the matter of “Embracer’s Bluff,” a location in the game featuring an AI-powered toilet and a large trash dump, according to a detailed Kotaku account of the place. Gearbox never commented on it; Take Two never got back to me about it when I asked them last year. By contrast, since Saber exited Embracer, Karch has been one of Embracer’s biggest defenders, casting their management as well-meaning and supportive despite the layoffs and studio closures that resulted from their excessive expansion. Like others, Saber’s Karch saw Embracer’s as a shot. With Rideshare Stimulator’s trailer, he’s returned fire. “It’s amazing to me how fast people forget those who went above and beyond for them,” Karch told Game File. A rep for Gearbox did not comment by press time. Game File is a reader-supported publication. Your backing makes my reporting—including any coverage of trailer-based beefs—possible. Good news! I’m currently running Game File’s first big sale of 2026. You can get a one-year subscription for 23% off. Click here to take advantage of the limited-time offer. And thank you for your support! Item 2: In brief… 🚫 Wal-Mart has laid off the staff of Restart, a games media outlet launched in 2024, Aftermath reports. 🟥 A GTA VI preview is on the way, at last, via an “extended look” that will premiere, unusually, on Netflix at 3pm ET on August 27, then officially go live elsewhere six hours later. Last week, Game File noted that Take Two label Rockstar Games is overdue for showing off GTA VI, based on the timing of the initial hands-off previews of GTA V and Red Dead Redemption 2. During a call with investors, Take Two CEO Strauss Zelnick said pre-orders for GTA VI were “unprecedented and astonishing,” but added the company can’t predict how many of those pre-orders represent bonus sales vs. sales that otherwise would have been made at launch. During the same call, Zelnick was noticeably bullish on the future of playing games over streaming cloud connections (predicting wider adoption in three or so years). He sounded unbothered by Sony’s plans to stop making discs for new games (he said the business is 90% digital already and predicted that there could still be limited edition physical editions of games “in the same way there’s still vinyl in the recorded music business.”) 👀 Take Two wrote off $43 million in their spring quarter after deciding “not to proceed with further development of an unannounced title in its pipeline from a third-party developer.” 🤔 Some rare age-demographics from a big publisher: Capcom recently told investors that “users in their 20s account for approximately half of the users of both Pragamata and Resident Evil Requiem.” Item 3: The week ahead Tuesday, August 11 Game releases: The Elder Scrolls IV: Oblivion Remastered (Switch 2; already out for PC, PS5, Xbox) continues the Bethesda strategy of putting Elder Scrolls games on everything; Royalty Free-For-All is a Smash Bros.-style fighting game featuring public domain characters such as Mother Goose brawling with Oliver Twist in a stage based on the original Little Shop of Horrors movie. Wednesday, August 12 Game release: Pro Jank Footy (PC, console) is an arcade-style Australian Rules Football game with increasingly ridiculous rules, the more you play (I enjoyed the Steam demo) Thursday, August 13 Game release: Super Mario Sunshine (Switch 2, originally released in 2002 on the GameCube) is released for Switch 2’s Nintendo Switch Online service. This game is the black sheep of 3D Mario games. It’s the successor to the breakthrough Super Mario 64 and the rare Mario game built around a single (vacation resort) theme. Mario’s got a water-spraying backpack, a Yoshi pal and a lot of blue coins to collect.
Biohaven Reports Recent Business Developments and Second Quarter 2026 Financial Results
First extracellular protein degraders in the clinic demonstrate rapid and robust pharmacodynamic effects and compelling safety in nearly 200 individuals dosed,...
Darline Graham’s Riding With Trump—But Political Views Beyond That Still Unclear As Primary Looms
Trump endorsed Darline Graham to replace her brother for a full term.
Boston Celtics Daily Links 8/10/26
All the Celtics news you need in one convenient place.
I Watched My Startup's Hidden Weaknesses Surface Overnight — Here's the 4-Part Stress Test Every Founder Should Run Before a Downturn Hits
Most companies don't break all at once — they crack in predictable places, and the founders who survive are the ones who pressure-test cash, dependencies, control and speed before the market forces them to.
The Steelers defense is still missing 3 of its key pieces, but their new coaching staff isn't concerned
Patrick Graham has been entrusted with running the Steelers defense, making sure it has some of the vestiges of the old 3-4 schemes Mike McCarthy embraces...
The new iOS 27 beta further expands Siri voice customization options
iOS 27 beta 5 has further expanded the new Siri voice customization options. In earlier betas, the new Pace and...
Sonos gets ready to launch new Ace Ultra headphones
With expanded Wi-Fi capabilities, the headphones may support the Sonos Voice assistant.
Will the Dome be deflated? Anchorage sports facility launches fundraising campaign.
The Dome has been the home of the state's largest indoor field for nearly 20 years. The facility's operators are asking for help funding the replacement of its exterior.
US Rep. Lauren Boebert’s son arrested, faces charges of sexual exploitation of child
U.S. Rep. Lauren Boebert’s son Tyler Boebert has been arrested and faces charges of sexual exploitation of a child, according to court records. The case originates out of Garfield County in Western Colorado. Tyler Boebert, 21, faces five counts in total: three charges of sexual exploitation of a child and two counts of contributing to […]
Self-flying air taxis and drones: Boeing sells key aviation technology businesses to Archer
Boeing is selling Wisk, SkyGrid and Insitu to Archer in a major deal combining autonomous aircraft, drones, airspace technology and AI.
Sophie Cunningham's comments renew debate over women's sports as WNBA faces questions
WNBA player Sophie Cunningham is once again at the center of the national debate over women's sports.
US Rep. Lauren Boebert’s son faces charges of sexual exploitation of child
U.S. Rep. Lauren Boebert’s son Tyler Boebert faces charges of sexual exploitation of a child, according to court records. The case originates out of Garfield County in Western Colorado and was filed on Thursday. Tyler Boebert, 21, faces five counts in total: three charges of sexual exploitation of a child and two counts of contributing […]
Ruf-powered, Porsche 959-inspired supercar brings 819bhp
Son of 1980s tuning hero reveals road-focused take on 911-based supercar, having built 40 desert racers
Ted Cruz’s college sports bill left in limbo as U.S. Senate takes August recess
Sen. Ted Cruz’s bill to place new regulations on college sports failed to reach the floor this week, imperiling its chances to become law this year.
Israel rejects Trump’s new Gaza peace plan
Israeli forces ‘will not carry out any withdrawal until Hamas is disarmed,’ Netanyahu said
No-Reserve 1977 Pontiac Firebird Trans Am Brings Bandit Style With a 400 V8 and Four-Speed
A no-reserve 1977 Pontiac Firebird Trans Am with a 400 V8, four-speed manual, and Bandit-style black-and-gold graphics is up for bid on Hagerty Marketplace, with Hagerty's valuation tools offering a window into what this second-generation Firebird is really worth.
Scientists Release Biggest 2D Map of the Universe
Key Takeaways The DESI Legacy Imaging Surveys combined more than 263,000 telescope exposures to make the largest 2D map of the universe in visible and near-infrared light. Astronomers can pair the Legacy Surveys map with their own observations to explore our universe and search for rare phenomena. The 2D map serves as the foundation for the Dark Energy Spectroscopic Instrument survey to measure the universe in 3D and investigate dark energy. Hold on to your telescopes: the DESI Legacy Imaging Surveys team has released the largest-ever 2D color map of the universe. The 5.6-trillion-pixel map contains nearly 4 billion celestial objects, primarily stars and galaxies. The data is available for all to use and publicly viewable through the Legacy Survey Sky Viewer. Astronomers and citizen scientists can explore the map or combine it with their own observations to better understand our universe. Researchers can search for rare phenomena like gravitational lenses, observe fleeting events like supernovae, and investigate two of physics’ biggest mysteries: dark matter, the invisible substance that accounts for most of the mass in our universe, and dark energy, the force driving our universe’s accelerating expansion. The new map builds on earlier versions from the DESI Legacy Imaging Surveys that have already proved invaluable. To date, more than 1,800 science papers that reference the Legacy Surveys data have been published. “It’s part of the fabric of astronomy research now,” said David Schlegel, a co-lead of the Legacy Surveys and scientist at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab). “When you’re working with astronomical objects today, you often start by pulling up the Legacy Imaging Viewer to see what you’re looking at.” Covering roughly 75% of the sky in visible and near-infrared light, the updated map provides a deep view of the extragalactic universe not blocked by the dust and stars of our own Milky Way. Researchers expect it will remain the most comprehensive 2D map of our universe for years to come. More than 160 scientists contributed to data collection for the project, and a team of 20 produced the final dataset released today. It was built by combining 263,407 telescope exposures from three ground-based sky surveys: the Dark Energy Camera Legacy Survey (DECaLS) at NSF Cerro Tololo Inter-American Observatory, the Mayall z-band Legacy Survey (MzLS) at NSF Kitt Peak National Observatory, and the Beijing-Arizona Sky Survey (BASS) at the University of Arizona’s Steward Observatory. That was supplemented by years of data from NASA’s Wide-field Infrared Survey Explorer (WISE) satellite mission and additional public data. “For our team, these data are fundamental to our investigation of the expansion history of the universe and the formation of our galaxy,” said Arjun Dey, co-lead of the Legacy Surveys and an astronomer at NSF NOIRLab. “But the skies belong to everyone, and this survey gives everyone the chance to explore the sky and marvel at its wonders.” Here be galaxies The DESI Legacy Imaging Surveys were originally conducted to prepare for the Dark Energy Spectroscopic Instrument (DESI) survey. The Legacy Surveys’ 2D map is essentially a deep photograph of the sky; it records where galaxies and stars appear and how bright they appear. This crucial step enables DESI to select objects and measure their light in different wavelengths to determine their distances, building the largest high-resolution 3D map ever made. Scientists study the way galaxies have clustered at different ages of the universe to track dark energy over time. In April 2026, DESI completed its original five-year survey ahead of schedule and with vastly more objects than expected. The early results have shown surprising hints that dark energy’s impact may be weakening over time — a paradigm shift that could potentially shape the predicted fate of our universe. DESI expects to publish improved results using their first five years of data in 2027 and is continuing observations into 2028. DESI was so efficient at observing galaxies, the Legacy Surveys map needed to expand. Early on, “it became clear we might run out of galaxies to look at and run out of sky, and we better start doing something about that,” said Schlegel, who also works on DESI. The new Legacy Surveys map has been used to select DESI targets since June 2026 and will guide the telescope’s operations over the coming years. Computing the cosmos Merging hundreds of thousands of images taken on 2,285 nights, each with unique atmospheric and telescope conditions, was a massive computational effort. It took about a year to develop the computer code and eight weeks to process all the images at the Perlmutter supercomputer at the National Energy Research Scientific Computing Center (NERSC) at Berkeley Lab. Beyond supporting DESI, the Legacy Surveys will be a foundational reference for the next generation of telescopes. As new observatories like the NSF-DOE Vera C. Rubin Observatory (jointly funded by NSF and DOE’s Office of Science) and NASA’s Nancy Grace Roman Space Telescope come online, researchers can compare their observations with one of the deepest and most comprehensive views of the sky ever assembled. The Legacy Surveys data will also help scientists train artificial intelligence tools to analyze petabytes of astronomical data and accelerate new discoveries. It will be among the datasets used in an astrophysics pilot project within the American Science Cloud, part of the DOE’s Genesis Mission. The DESI Legacy Imaging Surveys are supported by the U.S. Department of Energy’s Office of High Energy Physics; the National Energy Research Scientific Computing Center, a DOE Office of Science user facility; the U.S. National Science Foundation, Division of Astronomical Sciences; and the partner institutions. DESI is supported by the DOE Office of Science and NERSC. Additional support for DESI is provided by the NSF; the Science and Technology Facilities Council of the United Kingdom; the Gordon and Betty Moore Foundation; the Heising-Simons Foundation; the French Alternative Energies and Atomic Energy Commission (CEA); the Secretariat of Science, Humanities, Technology and Innovation (SECIHTI) of Mexico; the Ministry of Science and Innovation of Spain; and by the DESI member institutions. ### Lawrence Berkeley National Laboratory (Berkeley Lab) is committed to groundbreaking research focused on discovery science and solutions for abundant and reliable energy supplies. The lab’s expertise spans materials, chemistry, physics, biology, earth and environmental science, mathematics, and computing. Researchers from around the world rely on the lab’s world-class scientific facilities for their own pioneering research. Founded in 1931 on the belief that the biggest problems are best addressed by teams, Berkeley Lab and its scientists have been recognized with 17 Nobel Prizes. Berkeley Lab is a multiprogram national laboratory managed by the University of California for the U.S. Department of Energy’s Office of Science. DOE’s Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit energy.gov/science.
Lone Star Politics: Aug. 9, 2026
The Dallas City Council will vote on putting a $960 million public safety bond on the Nov. 3rd ballot. We spoke with the Dallas Police Chief about why Dallas needs the new Law Enforcement Training Center. Plus, an update on the Race for U.S. Senate.
Beebe Healthcare rolls out wearable safety buttons for frontline staff
Beebe Healthcare is rolling out wearable duress buttons for frontline employees as part of a new effort aimed at improving workplace safety across the health system.
Apple's Foldable iPhone Ultra Faces a Surging Samsung Galaxy Z Fold 8
Apple's foldable iPhone is expected to arrive in September against a rival already outrunning its own forecasts. ETNews reports Samsung is building an extra one million Galaxy Z Fold 8 units, after the 4:3 device took 70 percent of a record 1.44 million Galaxy Z8 series pre-orders. ETNews reports Samsung is building an extra one million Galaxy Z Fold 8 units, after the 4:3 device took 70 percent of a record 1.44 million Galaxy Z8 series pre-orders.
Why businesses may need to rethink how they plan
According to Axios, we have entered a new era of “post-processable velocity,” where the pace of technological and AI-driven change is faster than individuals, companies, markets and governments can fully absorb, understand or respond to in real time. The major shift is from information moving faster than humans can process to capabilities changing faster than […]
iPhone 18 Pro’s flagship new color detailed by leaker
Last year iPhone 17 Pro’s Cosmic Orange color proved a hit, but rumors indicate it’s being replaced in iPhone 18 Pro by a new burgundy.
Minnesota’s Democratic Senate Primary Pits Angie Craig Against Peggy Flanagan
The Senate primary race in Minnesota will be the latest test of left-wing energy in the party, in a state that was convulsed by the Trump administration’s deadly immigration crackdown this winter.
Lion Nebula Roars to Life With NASA’s Webb
Observing across the starry “plains” of space, NASA’s James Webb Space Telescope has taken new images of NGC 2392, nicknamed the Lion Nebula. NASA’s Hubble
Five Science Fiction Novels That Flirt With the Supernatural
Some of genre fictions most interesting stories live in the space where the scientific meets the supernatural...
Kelly Clarkson narrowly avoids a wardrobe malfunction at Vegas show
Kelly Clarkson was on stage at Caesars Palace Las Vegas when her sheer top blew up and she suffered a near-wardrobe malfunction.
Eleven Arkansas students place in 2026 Soybean Science Challenge
Eleven Arkansas students earned honors in the 2026 Soybean Science Challenge for innovative agricultural research and sustainable projects.
‘Don’t be afraid’: Alan Helgeson on knee replacement journey
Alan Helgeson lived with pain for decades before deciding to have total knee replacement surgery. Now he doesn't know why he waited so long.
No Man’s Sky Celebrates Its 10th Anniversary
No Man’s Sky celebrates 10 years of space adventures!
AP Decision Notes: What to expect in Connecticut’s state primary
Two veteran Democratic incumbents in Connecticut face strong challenges in a state primary on Tuesday.
Technosylva Fire Science Experts to Provide Bi-Weekly Wildfire Situational Awareness Briefings to Customers
/PRNewswire/ -- As extreme weather conditions continue to escalate, Technosylva, the global leader in wildfire and extreme weather risk intelligence, is...
Politics, Pubs, Parades, + the Parish: Carol Murphy Part 2: Finding Her Voice in Public Service
In Part 2, New Jersey Deputy Assembly Speaker Carol Murphy traces her unconventional path from the legal field.
Inter vs. Real Betis, where to watch it on TV
The beginning of the new season is getting closer and Inter are preparing for their final friendly before the league starts: on Saturday 15 August at 19:30 CEST, the Nerazzurri will face Real Betis at...
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice
AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.
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