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The DLSS 5 Backlash Is Still Swirling
Almost a week on, the controversy and backlash over NVIDIA’s DLSS 5 announcement are still swirling, following some mixed messaging from the company about how the tech works. A reveal trailer on Tuesday showcased multiple games like “Resident Evil Requiem,” “Starfield”, and “Hogwarts Legacy” using the new technology, which goes beyond simple upscaling and leads […]
Crews responding to fire burning behind an Upstate business
Multiple fire departments responded to a fire behind the Tractor Supply Co. in Mauldin, SC.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
The war on Iran is in its fourth week. Here’s what to know
Three full weeks of the war the US and Israel launched against Iran have shocked the world oil market, pierced a sense of safety in parts of the Middle East, and claimed the lives of US service members and civilians in multiple countries.
Coaches in elite company clash when Kansas faces St. John's
SAN DIEGO -- Only three active head coaches in Division I college basketball have won multiple national championships. Two of them meet for a berth in the Sweet 16 when Bill Self's No. 4 Kansas Jayhawks face Rick Pitino's No. 5 St. John's Red Storm on Sunday in the second round of the NCAA Tournament East Region.
'Eager to announce': Gurnee Mills mall announces multiple new stores, entertainment options opening
The owner of Gurnee Mills mall announced that multiple new stores and entertainment options, including IKEA, will be opening at the shopping mall over the next several months.
1 person hurt, multiple detained after overnight shooting in Surprise
An overnight shooting has left one person in the hospital in the West Valley on Saturday morning.
NASA’s Hubble accidentally caught a comet breaking apart in real time
In an incredibly lucky cosmic accident, NASA’s Hubble Space Telescope captured a comet breaking apart in real time—something astronomers have long tried and failed to observe. The comet, C/2025 K1 (ATLAS), wasn’t even the original target, but when researchers pivoted to it, they unknowingly caught it mid-disintegration into multiple pieces.
Kaiser Health Care unions ratify new contracts
LOS ANGELES, Cali. (KESQ) — After months of negations, including multiple strikes, UNAC/UHCP health care professionals have voted to ratify new contracts with Kaiser Permanente. During this negotiation period, union members walked off the job in January in what became the longest open-ended strike by nurses and health care professionals in U.S. history, lasting nearly
New AI tool predicts cancer spread with surprising accuracy
Researchers have discovered that cancer spread isn’t random—it follows a kind of biological “program.” By studying colon tumor cells, they identified gene patterns that signal whether a cancer is likely to metastasize. Their AI model, MangroveGS, can predict this risk with about 80% accuracy and even works across multiple cancer types. This could transform how doctors decide who needs aggressive treatment and who doesn’t.
Prairieville’s Sarah Taylor is scaling a health network for industrial growth
As Ascension Parish’s industrial boom continues to draw contractors and skilled workers to the region, the demand for occupational health services is rising alongside it. NuREADY Health Network is expanding its footprint across the Gulf South to help companies manage workforce testing, injury care and compliance across multiple job sites. Major industrial construction and maintenance […]
US furiously seeks to avert potential months-long closure of Strait of Hormuz
US officials are furiously trying to avert a potential months-long closure of the Strait of Hormuz, privately acknowledging that reopening the key waterway is a problem without a clear solution and dependent at least in part on what lengths President Donald Trump is willing to go to force the Iranian regime’s hand, multiple administration and intelligence officials tell CNN.
Analyst: Foldable iPhone Likely to Ship in December, iPhone 18 Plus is Possible Next Year
In a research note for investment bank Barclays earlier this month, Apple analyst Tim Long said his supply chain sources mentioned the possibility of the iPhone 18 base model being announced in March next year, rather than in September this year. This split launch has been widely rumored by multiple sources in recent months. More interestingly, Long dropped two unique pieces of information.
We (Still) Have the Science on Cumulative Impacts
That’s why we need cumulative impacts policies, which require the evaluation of multiple stressors and burdens so the decisions that get made are more comprehensive, effective, and equitable.
DarkSword iOS Exploit Kit Uses 6 Flaws, 3 Zero-Days for Full Device Takeover
DarkSword exploit targets iOS 18.4–18.7 using 6 flaws and 3 zero-days, enabling rapid data theft from iPhones across multiple countries.
California leaders lionized César Chávez. Now, they face a reckoning with his past
Leaders up and down California, many of whom were personally inspired by his life’s work, are grappling with multiple allegations of sexual assault by Cesar Chávez.
GOP blocks Booker-led push to curb Trump's military authority in Iran
Senate Democrats plan multiple war powers resolutions to challenge President Trump's Iran military operations in a bid to force public testimony from top administration officials.
NN, Inc. Provides Update on Business Growth in the Data Center, AI Reasoning, and Cloud Computing Markets
CHARLOTTE, N.C., March 18, 2026 (GLOBE NEWSWIRE) -- NN, Inc. (“NN” or the “Company”) (NASDAQ: NNBR), a global diversified industrial company that engineers and manufactures high-precision components and assemblies with six sigma quality, today provided an update on its growing presence in the data center market, a key targeted growth market for the Company. NN has secured multiple new awards with a leading global provider of AI infrastructure and data center computing equipment. As this industry
5 Portland sports bars where you can watch every wild March Madness moment this year
From an early-bird option near the Moda Center to a neighborhood spot devoted to women's sports, these Portland bars offer full menus and multiple TVs for tournament viewing.
Lenovo brings retro arcade cabinet gaming to high-end Android tablets with new releases
Lenovo has released a new set of accessories for its compact gaming tablets. Compatible with multiple tablet generations, the Legion Y700 Arcade Dock comes in three finishes with dedicated SNK versions too.
Google is quietly testing a Discover tab in Gemini, alongside a host of UI changes
We spotted a mysterious new Discover tab and multiple Gemini UI changes in our latest APK teardown of the Google app.
What breaks first when your business scales to multiple locations
Stamps.com reports that multi-location growth reveals operational misalignments and that managing varied tools and vendors complicates efficiency and increases costs.
How lawyers got their hands on thousands of private patient records
The nation’s largest health records company, Epic Systems, has sued multiple firms including GuardDog Telehealth, alleging they had improperly accessed personal medical records.
Lendzi Business Loans Review 2026
Lendzi is an online loan marketplace where you can compare business loans from multiple lenders with one simple application.
Study finds ChatGPT gets science wrong more often than you think
A new study put ChatGPT to the test by asking it to judge whether hundreds of scientific hypotheses were true or false—and the results were far from reassuring. While the AI got it right about 80% of the time on the surface, its performance dropped significantly when accounting for random guessing, revealing only modest reasoning ability. Even more concerning, it frequently contradicted itself when asked the exact same question multiple times, sometimes flipping answers back and forth.
E. coli outbreak linked to raw cheddar cheese allegedly sickens 7 people across multiple states
E. coli outbreak allegedly linked to raw cheddar cheese affects 7 people across California, Texas and Florida, with most victims under 3 years old.
Jasmine Crockett confirms member of her security team killed by Dallas police
She said the man, Diamon Robinson, had gone by a different name during his employment. Police said he had "multiple felony warrants" and a parole violation warrant.
The top 2026 Las Vegas residencies you don’t want to miss: How to purchase the best tickets
Several artists across multiple genres are planting temporary roots in Las Vegas for some upcoming and highly anticipated Las Vegas residencies at venues including the Sphere, The Colosseum at Caesars Palace and more.
10 Audio Improvements in Apple's New AirPods Max 2
Apple refreshed the AirPods Max today, and the main new addition is an H2 chip that replaces the H1 chip. The H2 chip has previously been used in the AirPods 4 and the AirPods Pro 2 and later, but it's new to the AirPods Max. It brings multiple audio improvements alongside an updated high dynamic range amplifier. We've listed all of the audio features that are new to the AirPods Max according to Apple.
Louisiana-filmed vampire and blues film "Sinners" wins multiple Academy Awards
Nominated for a record-breaking 16 Academy Awards, the film "Sinners" took home four.
Health officials investigate E. coli outbreak linked to raw cheese sold in Florida
Health officials are investigating an outbreak of E. coli in multiple states, including Florida, that appears to be linked to raw cheese products.
Oppo, OnePlus, and Vivo officially announce smartphone price increase in China
Rising RAM and semiconductor costs are pushing Chinese smartphone brands to adjust their pricing. Oppo, OnePlus, Vivo, and iQoo are among the latest to announce price hikes across multiple devices in China.
Small Businesses Are Pushing Back Against Private Equity
Touting local and family-owned credentials, Main Street companies say they’re fending off sometimes multiple inquiries a day from PE firms.
Warner Bros Montréal reportedly hit with staff cuts
Former employees state that roles across multiple divisions were made redundant last Friday
FIU defeats UTEP softball in DH to sweep series
MIAMI, Florida – UTEP softball finally saw action late Friday night after multiple weather-related schedule changes but ultimately fell to FIU, 4-3, in the series opener. Originally scheduled as part of a three-game series across three days, the weekend slate was first moved to an early Friday doubleheader and Saturday single game before prolonged lightning delays pushed the matchup to […]
Widespread School, Government Office, Business Closures Monday
Widespread closures have been announced across northern Michigan Monday amid a winter storm that has hammered the state, producing significant icing across the region. Strong predicted winds and a continued winter storm warning through Monday could exacerbate impacts to infrastructure, especially for areas with icing on trees and power lines. Multiple schools in the Grand …
I heart this media.
This weekend’s Saturday Night Live episode hosted by Harry Styles had multiple bangers and I’ve been really impressed by the writing team over the past couple seasons. But this latest bit on Weekend Update about the social status of emojis felt exceptional. I don’t want to spoil it, but… “RBF: right before the flags” is some of the smartest writing on the show in a long time. This skit took the aerial tramway directly to my own heart. [Media: https://www.youtube.com/watch?v=59CpJqCbxXs]
Can a groundbreaking cancer therapy help people with multiple sclerosis?
A handful of small, early-stage clinical trials are investigating whether CAR-T therapy can improve symptoms in multiple sclerosis patients.
NBCUniversal cancels multiple talk shows, longtime entertainment news program
The cancellations are expected to result in layoffs for the shows’ crews and executives within the NBCU first-run division.
Titans add impact defender in latest CBS Sports post-free agency mock
The Tennessee Titans have added multiple free agents on defense, but that doesn't stop one analyst from giving them another impact defender in the draft.
Islanders see benefit of grabbing early lead against Flames
The New York Islanders finally learned Friday night they can't always come back and win after falling behind by multiple goals.
Multiple House Republicans post openly anti-Muslim statements
At least four House Republicans have expressed anti-Islamic sentiments on social media in the wake of the Iran War and recent violent attacks in the U.S.
US troops used ATACMS missile to sink Iranian ships, submarine: Caine
US troops in the Middle East have used a ground-based ballistic missile system to sink multiple Iranian ships, Gen. Dan Caine said.
Air quality health advisory issued in multiple counties over wildfire smoke
The Colorado Department of Public Health and Environment issued a health advisory for multiple counties Friday morning, due to wildfire smoke.
A record number of political parties register for Haiti's first election in a decade
A record 280 political parties had registered by Thursday's deadline to participate in Haiti's first general election in a decade, hopeful for a chance to help ease their country's multiple crises.
Former Orlando Health employee arrested on charges of soliciting a minor
Central Florida man faces multiple charges, including soliciting a minor for sex, following an investigation that began last September.
Trump administration underestimated Iran war’s impact on Strait of Hormuz
The Pentagon and National Security Council significantly underestimated Iran’s willingness to close the Strait of Hormuz in response to US military strikes while planning the ongoing operation, according to multiple sources familiar with the matter.
Sports bar along New Bern Avenue in Raleigh loses permits after multiple shootings
The North Carolina ABC Commission has officially suspended the operating permits for Touchdown Sports Bar in Raleigh following a series of violent incidents over the past year or so.
Michigan reports 1st measles case of 2026: What you need to know
Health officials say an adult with measles exposed others to the virus between March 4-8 at multiple locations across two Michigan counties.
California Democrats hope new polling will nudge candidates to exit
The California Democratic Party chair said Tuesday that the party is spending “multiple six figures” to conduct and post six surveys of the race.
Halfpricesoft.com Launches 2026 ezPaycheck Network Version to Empower Growing and Remote-Ready Businesses
Halfpricesoft.com announces the release of the latest 2026 ezPaycheck payroll software , now available in a powerful network version designed to support growing companies and remote teams. This enhanced edition allows businesses to securely share payroll data between multiple offices while enabling simultaneous printing of payroll checks and tax forms, streamlining operations for organizations with expanding workforces and distributed staff.
Anthropic executives say Pentagon blacklisting could hit billions in sales, harm reputation
Anthropic executives said the U.S. government's blacklisting of the AI firm could cut its 2026 revenue by multiple billions of dollars and cause reputational harm.
Multiple Louisiana health systems jointly launch MyChart Central for unified patient experience
Several Louisiana health systems have jointly launched MyChart Central, creating the first statewide, unified patient portal experience.
Evaluating Sphere Entertainment (SPHR) After A Strong Multi‑Month Share Price Run And Rich P/E Multiple
Why Sphere Entertainment Has Caught Investor Attention Sphere Entertainment (SPHR) has been drawing more interest lately, with the stock showing a mix of short term pullbacks and stronger returns over the past month and over the past three months. See our latest analysis for Sphere Entertainment. At a share price of $112.82, Sphere Entertainment has seen short term share price softness, with a 1 day return of a 0.85% decline and a 7 day return of a 1.38% decline, set against a 30 day share...
ESPN Scoops Up Multiple Ex-Washington Post Sports Reporters
Multiple outlets have hired former Post reporters since the newspaper shuttered its sports section in early February.
Radiology Partners’ AI business receives Breakthrough Device designation from FDA
The country’s largest imaging group announced the news March 5, with the decision applying to its Cognita Chest X-ray tool across multiple clinical indications.
Shots fired at Rihanna's Beverly Hills home, suspect taken into custody
Multiple shots were fired toward Rihanna's Beverly Hills home on Sunday afternoon, LAPD confirms. The "Umbrella" singer was home at the time of the shooting, according to news reports, but no one at the residence was harmed, the LAPD confirmed.
Oil change business closes due to theft by multiple employees: South Euclid Police Blotter
The Take 5 Oil Change temporarily closed Feb. 26 so that a theft by multiple employees could be investigated.
Mental health partnership strengthens care during LAMAT 2026 in Saint Kitts and Nevis
As the Lesser Antilles Medical Assistance Team (LAMAT) 2026 mission concluded in Saint Kitts and Nevis, mental health professionals from the U.S. Air Force and local providers reflect on the partnerships built and the impact of their collaboration on mental health care across the islands. Working under the guidance of the Ministry of Health, the LAMAT mental health team partnered closely with local clinicians to better understand community needs while supporting care for patients across multiple settings.
How is the Iran war reshaping the world and politics here at home?
For the last week, Israeli and US bombs have devastated Iran. And the conflict has widened to include multiple countries in the Gulf. How is the conflict reshaping the world order and impacting Trump’s popularity here in the United States?For sponsor-free episodes of Consider This, sign up for Consider This+ via Apple Podcasts or at plus.npr.org. Email us at considerthis@npr.org.This episode was produced by Connor Donevan, Elena Burnett, Alejandra Marquez Janse and Erika Ryan. It was edited by Barrie Hardymon, Tara Neill, Dana Farrington, Jeanette Woods and Courtney Dorning. Our executive producer is Sami Yenigun.
Five ways Bella Abzug opened up politics to women and fought for social change | American Masters
Politician Bella Abzug broke ground for women in Congress and introduced multiple pieces of legislation that expanded women's rights.
Suns' Ighodaro favored, Maluach struggles in Bulls loss
With Mark Williams on the shelf for multiple weeks, Oso Ighodaro showed his comfort against the Bulls while Khaman Maluach played like a rookie.
Alec Pierce is Super Bowl team’s top free agent target
NFL free agency is set to begin in less than a week. Multiple teams will lose their top talent despite their best efforts to work out contract negotiations. The Indianapolis Colts are one of those teams. After trying to retain…
Trump weighs replacing Noem as frustrations build among White House officials, GOP lawmakers
President Donald Trump is privately weighing replacing Homeland Security Secretary Kristi Noem amid mounting frustrations both in the administration and on Capitol Hill over her management of the department, according to multiple sources who spoke with CNN.
Multiple Fights Confirmed for UFC Winnipeg on April 18
The UFC Winnipeg lineup is gradually taking shape.
OpenAI brings its Codex coding app to Windows
The software allows developers to task multiple AI agents to work on a single task.
Sources: Sphere Entertainment considers venue in Nashville
Multiple sources tell Axios that Sphere reps have held talks with local executives.
Government-grade iPhone exploit kit spreading to hackers: reports
Google and iVerify have shared details about Coruna, an exploit kit that chains multiple vulnerabilities to target iPhones running older iOS versions.
Barnesville fire destroys two Market Street businesses overnight, no injuries reported
Officials say a devastating overnight fire in downtown Barnesville destroyed two businesses, but no lives were lost as multiple agencies worked through the night to contain the flames.
Cleaning business owner accused of repeatedly stealing and pawning clients’ jewelry
Polk County cleaning business owner arrested for stealing and pawning jewelry from clients' homes. Multiple felony charges filed.
Former president of Marion business convicted of federal bankruptcy crimes
A former president of a now-defunct Marion business was convicted of multiple federal bankruptcy crimes Monday after prosecutors say he concealed assets and provided false statements during his bankruptcy proceedings.
Oracle Loses Health Unit Leaders With Ellison’s Bet Struggling
Oracle Corp.’s health records division has lost multiple senior leaders in recent months while the company works to modernize its software in the face of steep customer loses.
The Risky Politics of Trump’s New War With Iran
While most Americans will view the war through a partisan lens, there are multiple ways it could backfire with swing voters.
Seattle Times sports staff honored with multiple national awards
The Seattle Times – competing in Division A, the largest print circulation and website division – earned Top 10 honors in four categories of the APSE Contest.
Colorado Republicans, Democrats clash over Iran military operation
Colorado’s congressional delegation split sharply along party lines Saturday after the U.S. and Israel attacked Iran, triggering a fresh debate in America over presidential war powers. Trump announced early Saturday morning that U.S and Israeli forces had begun “Operation Epic Fury” after multiple explosions were reported around Iran. Later in the day, the president said that […]
Iran fired missiles into multiple countries. Here's what happened.
Iran appears to have launched strikes into at least six countries. It said it was targeting US military bases in the region.
Lenovo ThinkBook Modular AI PC and Yoga Book Pro 3D leak ahead of MWC 2026
Lenovo experimenting with concept PCs focusing on modular and dual-display designs Lenovo is expected to show multiple concept PCs at MWC 2026 in
Pentagon Casts Cloud of Doubt Over Anthropic’s AI Business
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PRET for impact: Advancing pandemic preparedness in the Democratic People’s Republic of Korea
IN THE SPOTLIGHT PRET for impact: Advancing pandemic preparedness in the Democratic People’s Republic of KoreaThe Democratic People’s Republic of Korea (DPR Korea) is making significant progress in strengthening pandemic preparedness, with dedicated support from the WHO South‑East Asia Regional Office (SEARO) and the Pandemic Influenza Preparedness (PIP) Partnership Contribution (PC).Aligned with the WHO Global Influenza Strategy and the Pandemic Influenza Preparedness (PIP) Framework Partnership Contribution High‑Level Implementation Plan III (2024–2030), the country is strengthening its capacity to prepare for and respond to influenza and other respiratory threats. In early 2025, a core team from the Ministry of Public Health of the Democratic People’s Republic of Korea (DPRK) participated in a two‑day virtual workshop, which included a mini‑simulation exercise. The workshop was organized by WHO SEARO in collaboration with the Preparedness and Resilience for Emerging Threats (PRET) Secretariat at WHO headquarters and the WHO Country Office for the DPRK. Read more A REGIONAL CONSULTATION GUIDES WHO SEARO IN DEVELOPING A ROADMAP FOR IMPLEMENTING THE PREPPAREDNESS AND RESILIENCE FOR EMERGING THREATS (PRET) INITIATIVE BASED RESPIRATORY PATHOGEN PANDEMIC PREPAREDNESSInfluenza and other respiratory pathogens with pandemic potential continue to pose major public health risks globally. To strengthen regional preparedness and response, Member States of the WHO South‑East Asia Region (SEAR) convened in Colombo, Sri Lanka, to review and provide input on the draft Roadmap and Action Framework for Broad Respiratory Pathogen Pandemic Planning (2026–2031). Supported through the Pandemic Influenza Preparedness (PIP) Partnership Contribution (PC) funds, the proposed roadmap aims to advance robust, integrated preparedness and response capacities for influenza and other respiratory threats across SEAR. This work is aligned with the Preparedness and Resilience for Emerging Threats (PRET) initiative and the SEAR Strategic Roadmap on Health Security and Health System Resilience for Emergencies Read moreSRI LANKA’S USE OF ANTIVIRALS TO REDUCE THE SEASONAL INFLUENZA BURDEN Sri Lanka is strengthening its influenza response by placing greater emphasis on rapid testing, timely treatment, and integration with maternal health services. With support from WHO, the country is building a stronger evidence base on the burden of influenza and the value of vaccination, advancing a holistic approach to protect vulnerable populations and enhance pandemic preparedness. To reduce hospitalizations and deaths from seasonal influenza, Sri Lanka is taking proactive steps to expand access to rapid diagnostic testing and ensure prompt initiation of treatment. National clinical guidelines recommend the use of oseltamivir for individuals at high risk of complications, helping prevent severe illness and shorten the duration of infection. This strategy not only saves lives but also supports local pharmaceutical production, contributing to a reliable supply of antivirals for both seasonal outbreaks and future pandemics.Read moreBHUTAN BOOSTS PANDEMIC INFLUENZA READINESS WITH PANDEMIC INFLUENZA PREPAREDNESS FRAMEWORK PARTNERSHIP CONTRIBUTION SUPPORTED TRAINING AND SIMULATIONSOriginally developed in 2012, the National Influenza Pandemic Preparedness and Response Plan (NIPPRP) has long served as Bhutan’s central framework for managing influenza threats. In 2024, the plan underwent a comprehensive update to reflect evolving global and regional guidance, lessons learned from the COVID‑19 pandemic, and new capacities developed under the PIP Framework. The revised NIPPRP is now more clearly aligned with Bhutan’s broader emergency and disaster risk management structures, ensuring a coordinated, whole‑of‑government approach to pandemic response. As part of efforts to strengthen national pandemic preparedness, Bhutan conducted three national‑level training sessions followed by simulation exercises on influenza pandemic preparedness and response at five sentinel hospitals between April and May 2025, with support from the PIP Partnership Contribution (PC). These activities brought together more than 140 health professionals and key partners from across the country, with a focus on operationalizing the updated NIPPRP and enhancing readiness at key frontline facilities. Read moreSTRENGTHENING INFLUENZA SURVEILLANCE: WHO BRINGS TOGETHER INFLUENZA EXPERTS FROM SOUTH-EAST ASIA AND WESTERN PACIFIC REGIONSThe World Health Organization (WHO) convened the 18th Bi‑regional Meeting of National Influenza Centres (NICs) and Influenza Surveillance for the WHO South‑East Asia and Western Pacific Regions from 9–11 September 2025. Hosted by the WHO South‑East Asia Regional Office (SEARO), the meeting brought together representatives from Member States, Territories, and Areas across both regions, alongside experts from the WHO Collaborating Centres for Reference and Research on Influenza in Australia and Japan, the WHO Collaborating Centre for Studies on the Ecology of Influenza in Animals in the United States, quadripartite partners (WOAH and FAO), and other technical counterparts. The consultation provided a platform to review progress, share experiences, and outline priorities for strengthening influenza and respiratory pathogen surveillance across the two WHO regions.Read moreNETWORKS AND TECHNICAL PARTNERSHIPSSTRENGTHENING PANDEMIC READINES: SOUTH-EAST ASIA ADVANCES UNITY STUDIES UNDER THE PANDEMIC INFLUENZA PREPAREDNESS INITIATIVEThe WHO Global Influenza Surveillance and Response System (GISRS) Investigations & Studies initiative, also known as Unity Studies, provides a standardized, globally coordinated framework to support these efforts. Originally developed for influenza and adapted during COVID-19, Unity Studies enable countries to conduct rapid, nationally led investigations and studies to assess transmissibility, severity, susceptibility, and intervention effectiveness. To better prepare for future influenza pandemics, WHO has recently launched a network of sites which will be ready to conduct these investigations and studies rapidly in the event of a pandemic, or epidemic of an emerging or re-emerging respiratory pathogen. The WHO South-East Asia Region now hosts six sites of WHO GISRS Unity Studies across the five countries including Sri Lanka, strengthening regional capacity for early pandemic investigations. From 13–16 July 2025 in Colombo, the Global Public Health Summit offered an opportunity to advance this agenda. Read moreSTRENGTHENING PANDEMIC PREPAREDNESS THROUGH UNITY STUDIES: REAL-WORLD APPLICATIONS FROM INDIA IN WHO’S SOUTH-EAST ASIA REGION As countries continue to strengthen their pandemic preparedness through investments in resilient health systems during the interpandemic period, the World Health Organization’s (WHO) Global Influenza Surveillance and Response System (GISRS) Investigations & Studies Global Initiative, Global Initiative, commonly known as Unity Studies, remains a vital framework for respiratory pathogen pandemic preparedness. These standardized epidemiological protocols enable countries to rapidly generate high‑quality data on transmissibility, infection severity, population immunity, and the effectiveness of public health interventions. To highlight how Unity Studies protocols are being adapted and applied in national settings, WHO Headquarters, together with WHO Regional Offices, including the WHO South‑East Asia Regional Office (SEARO), hosted a global webinar. The session showcased case studies from India and the United Kingdom (UK), demonstrating innovative approaches to respiratory virus surveillance and pandemic readiness. Read moreSTRENGTHENING REGIONAL INFLUENZA SURVEILLANCE AND PREPAREDNESS: WHO SEARO HOSTS HIGH-LEVEL WEBINAR AMID RISING H5 THREATS In response to the increasing detection of avian influenza A(H5) cases in humans globally and within the WHO South‑East Asia Region, the WHO Regional Office for South‑East Asia (SEARO) convened a regional webinar on 25 July 2025 to review preparedness mechanisms, strengthen surveillance pathways, and promote timely reporting of unusual respiratory events. The virtual session brought together more than 50 participants from Ministries of Health, National Influenza Centres (NICs), National IHR Focal Points (NFPs), WHO Headquarters, WHO Country Offices across the Region, and WHO Collaborating Centres (CCs) for influenza. The webinar provided an opportunity to share situational updates, discuss surveillance gaps, and reinforce coordination mechanisms critical for early detection and rapid response to avian influenza threats. Read moreOther Key PIP Updates (July-December 2025)MEMBER STATES:Bangladesh drafted and conducted a series of Core Group Meetings in 2025 to review and update the National Pandemic Preparedness and Response Plan for Respiratory Pathogens. In addition, the country carried out Rapid Response Team (RRT) trainings on seasonal and avian influenza and other re‑emerging infectious diseases. Bangladesh also updated its epidemiological data‑training programme for physicians at sentinel surveillance sites, using a revised epidemiological data‑collection tool.Bhutan revised and updated its National Influenza Pandemic Preparedness and Response Plan (NIPPRP) in 2025 and developed a national Standard Operating Procedure (SOP) for influenza outbreak management. DPR Korea conducted a nationwide simulation exercise in July 2025 to support the update of its National Influenza Pandemic Preparedness Plan (2019). This followed a PRET‑based virtual orientation and mini‑simulation exercise held in May 2025 by SEARO and the WHO PRET Secretariat. The comprehensive exercise, conducted across central and provincial levels, assessed strengths and gaps in pandemic influenza preparedness and response. The feedback gathered has been incorporated into the revised draft plan to address identified weaknesses and strengthen overall readiness.India conducted a targeted nationwide online re‑orientation training on review and updates to the influenza portal for all State Surveillance Officers (SSOs) and relevant officials using the Integrated Health Information Platform (IHIP). The training emphasized correct marking and reporting of influenza samples as “unsubtypable” or “not subtyped” where applicable, to ensure accurate national surveillance.Maldives conducted simulation exercises in three atolls based on its existing National Pandemic Preparedness and Response Plan (NPPRP). The country plans to conduct similar exercises in three additional atolls after updating the NPPRP in 2026. In addition, Maldives conducted training on FluID and FluMart as part of a broader data‑management training package for Ministry of Health and Health Protection Agency officials, aimed at improving routine reporting to WHO platforms and the DHIS2 system.In Myanmar, technical support was provided to the National Influenza Centre (NIC) through dedicated human‑resource support (January–December 2025) to sustain data management and laboratory detection capacity for influenza and other emerging and re‑emerging respiratory viruses. This support also included strengthening genomic sequencing capacity.Nepal conducted a consultative workshop on the National Pandemic Preparedness and Response Plan (NPPRP) in July 2025. The workshop engaged key stakeholders from multiple sectors to review lessons from past pandemic responses, assess current mechanisms, and gather critical inputs for strengthening national preparedness. Key recommendations included revising the 2019 NPPRP and developing an updated Influenza Pandemic Preparedness Plan aligned with emerging risks, national priorities, and relevant international frameworks. Nepal also held a two day workshop dedicated to advancing the National Action Plan for Genomic Surveillance, aimed at reinforcing the country’s capacities for early detection and monitoring of emerging respiratory pathogens.Sri Lanka received the final report from WHO on the feasibility assessment for conducting an Influenza Burden of Disease (BoD) study in the country. The assessment, conducted from 28 April to 9 May 2025, included a desk review of existing data sources, document review, visits to sentinel surveillance sites, and key informant interviews. The study identified critical data sources required for a future BoD assessment, as well as their availability and quality. Officials from the Epidemiology Unit, the National Influenza Centre (NIC), and SARI/ILI sentinel hospitals across the country participated in the assessment.Timor Leste conducted on‑the‑job training and monitoring activities at two sentinel surveillance sites to strengthen surveillance and laboratory capacity for the detection of SARI, ILI, ARI, and other respiratory infections. REGIONAL OFFICE:SEARO conducted a Member States Consultation on the first draft of the Regional Roadmap and Strategic Action Framework for implementing WHO’s PRET‑based broad respiratory pathogen pandemic planning for 2026–2031. The consultation took place on 29–30 October 2025 during the final two days of the Regional PIP PC Annual Review and PRET Meeting in Colombo, Sri Lanka. Participants included representatives from Member States, WHO Country Offices, WHO SEARO, WHO Headquarters, partner agencies, and invited multidisciplinary technical experts. They reviewed the draft and provided detailed feedback, which has since been incorporated into a revised version. The consultation helped shape a shared regional vision for robust, PRET‑aligned pandemic preparedness, building on country‑level progress, addressing existing gaps and challenges, and aligning with global and regional health security frameworks. The publication is planned for release during the SEAR regional committee in 2026.SEARO documented the evolution of the National Influenza Pandemic Preparedness Planning process in the Region, tracing its development from its origins as a planning tool for responding to avian influenza outbreaks in 2006, through the experiences of the 2009 and 2019 pandemics, to the current status. The document outlines the way forward for respiratory pathogen pandemic planning across all 10 SEAR countries, aligning future national plans with WHO’s PRET Framework for broad respiratory pathogen pandemic preparedness.The Infectious Hazard Management (IHM) Unit has drafted the WHO South‑East Asia Regional Guidance on Influenza Prevention and Control, aligned with the Global Influenza Strategy and other regional initiatives. The draft is currently under review. Although this technical product was developed in response to a request from the Ministry of Public Health of the Democratic People’s Republic of Korea (MoPH‑DPRK), SEARO is finalizing it for use not only in DPRK but also across all Member States in the Region.The Immunization and Vaccine Development (IVD) Unit, in collaboration with WHE/SEARO, completed a regional landscape analysis on key barriers, challenges, and opportunities for the introduction of seasonal influenza vaccination in WHO South‑East Asia Regional (SEAR) countries.Additionally, the Immunization and Vaccine Development (IVD) Unit has completed a regional landscape analysis of influenza vaccine procurement systems across the WHO South‑East Asia Region (SEAR).KEY MEETINGS AND PUBLICATIONSMEETINGS:Six-month progress review of the implementation of the PIP-PC workplans in SEAR, focusing on Outputs 1 and 2 for the period January to June 2025, and held virtually across three sessions on 4, 8, and 10 July 2025. Read moreAnnual Regional Meeting (Hybrid) on Pandemic Influenza Preparedness (PIP) Partnership Contribution (PC) and WHO’s Preparedness and Resilience for Emerging Threats (PRET) Implementation in SEAR in Colombo, Sri Lanka, 27 to 30 October 2025. Read more18th Bi-regional Meeting (Virtual) of National Influenza Centres (NICs) and influenza surveillance in WHO South-East Asia and Western Pacific Regions from 9 to 11 September 2025. Read morePUBLICATIONSImplications of influenza A virus surveillance in Southeast Asian Region countries: a scoping review of approaches for the surveillance of swine influenza viruses at human-swine interfaces. Read moreAnnual South-East Asia regional meeting on operational planning for implementation of global influenza strategy and preparedness for respiratory viruses in 2025 Report on annual review meeting of implementation of pandemic influenza preparedness (PIP) partnership Contribution (PC) Fund in South-East Asia Region and the simulation exercise on PRET Status of influenza in who south-East Asia Region
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