SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " LDS " 2,912 found 🔀 AI-powered Shuffle
Meet the founder betting Africa's next entertainment giant will be built on ownership, not just storytelling
The worlds biggest entertainment companies arent valuable because they make great films or television
2026 World Cup: Short-handed England holds off Mexico at home behind 2-minute Jude Bellingham brace
One year after Hill Country floods, Ingram couple rebuilds home, business
Lauren Westbrook revisits an Ingram couple one year after they lost their home and business to Hill Country flooding.
Autographed Sports Memorabilia Trends 2026: The Players and Items Worth Chasing This Summer
Today in this blog on Athlon Sports, we will discuss autographed sports memorabilia trends 2026 and the top assets this summer. Dedicated hobbyists are driving immense liquidity into physical assets right now. Tracking major roster shifts yields great results.
Sun Life completes $350 million acquisition of Bell Partners
The deal folds a leading US multifamily manager into Sun Life's BGO real estate platform
Retiree in Newark spends $150 a week on groceries: food budget
John Goldstein, a 75-year-old retiree in New Jersey, says he still eats well even as he budgets to manage rising health costs.
Veteran family rebuilds after hurricane, fire and health setbacks
A mailbox can be a small thing, but for the Fields family, it’s a symbol of community, connection and a second chance.
Virginia Hemp Farmers And Businesses Worry About Changes Included In Newly Passed Marijuana Market Legislation
Legislators want to “change the law that they created, to clearly favor Wall Street corporations over Virginia farmers and small businesses.” By Charlotte Rene Woods, Virginia Mercury A legal cannabis market is set to take effect in Virginia next summer under the final state budget, but Mannassas-based Barbara Biddle has already given notice to her […]
Trump’s $2bn bonanza heralds the rise of political grifters across the west
With voters embracing leaders who brazenly monetise public office, experts say an ethical code is breaking down
NASA's Hubble captures a crimson stellar nursery sparkling with blue and white stars
Hubble has captured a spectacular view of LH 95, where about 2,500 young stars are still on their journey to becoming full-fledged stars. Scientists discovered these growing stars can keep pulling in gas and dust for millions of years, extending an important stage of stellar development. The region also contains multiple generations of stars living side by side, offering fresh clues about how star formation unfolds over time.
Scientists discover the deep sleep circuit that builds muscle, burns fat, and boosts the brain
Researchers have identified the brain circuitry that links deep sleep with the release of growth hormone, revealing how the two regulate each other. The newly discovered feedback loop helps explain why poor sleep can interfere with growth, muscle repair, fat metabolism, and brain function. Understanding this system could pave the way for new therapies for sleep disorders and diseases tied to metabolism and the brain, including Alzheimer's and Parkinson's.
Did The Retroid Pocket Flip 3 Just Get Officially Confirmed?
Retroid appears to confirm a new dual-screen handheld for late 2026, fueling speculation that the Pocket Flip 3 is finally on the way this year.
Sapp’s Diesel & Truck Center builds business on family, faith, and ‘Quality Without Compromise’
Sapps Diesel & Truck Center is not the kind of place owner Brock Sapp wants people to find only after they have been everywhere else. Located at 1955 Old Register Way in Statesboro, the family-owned truck repair shop specializes in light-duty diesel
11 US states where the 30% housing rule still holds up
The 30% rule for buying a home still works in these 11 states — but not a single one is in the South.
The World Cup is just now discovering Middle America’s big heart. These Irish bingo kingpins built a $24 million business knowing it all along
Craig Reynolds and Will Meara launched Bingo Loco in a Dublin basement in 2017. Nine years later, Locomotive sells a million tickets a year in 300 cities.
Firework chemistry: the science behind firework colors
Different chemical compounds create the brilliant reds, blues, greens and golds you see bursting overhead.
Florida politics recap: Byron Donalds strengthens grip on GOP governor's race as rivals battle in court
It was a week of escalation in Florida politics: a governor's race lawsuit, new restrictions aimed at undocumented students, and a fresh legal fight over Gov. Ron DeSantis' push to label CAIR and other groups as terrorist organizations.
Governor Moore Announced Energy Assistance To Lower Utility Bills for 200,000 Maryland Households, Wrote On How To Improve Young Men’s Mental Health, Applauded SCOTUS Decision To Uphold Birthright Citizenship, And A Local Farmer Said ‘Gov. Moore Takes Action For Farmers’
This past week, Governor Wes Moore announced energy assistance programs to help lower utility bills for 200,000 Maryland households, published an opinion piece on how to improve young men’s mental health, applauded the SCOTUS decision to uphold birthright citizenship, and a local farmer applauded his work to secure a USDA Secretarial Disaster Declaration. Governor Moore […]
Old muscle stem cells can act young again but there’s a catch
Scientists at UCLA discovered a surprising reason aging muscles heal more slowly. In older muscle stem cells, a protein called NDRG1 builds up and acts like a brake, slowing the cells’ ability to jump into repair mode after injury. But there’s a twist: that same protein helps the cells survive the stresses of aging, allowing them to stick around longer.
The Week in Business: Congress Is About to Kill the Hemp Industry It Created
This week’s top stories from Twin Cities Business.
Ribbon-cutting ceremony opens Texas Health Mansfield Stadium to the public
The new home of North Texas SC will host international soccer, concerts and community events as Mansfield looks beyond the World Cup.
Avowed, The Outer Worlds, and Fallout: New Vegas Developer Obsidian Entertainment Reportedly Also at Risk of Closure Amid Xbox 'Reset'
Avowed and The Outer Worlds developer Obsidian is reportedly also at risk of closure amid Microsoft’s “reset” of the Xbox business.
Avowed, The Outer Worlds, and Fallout: New Vegas Developer Obsidian Entertainment Reportedly Also at Risk of Closure Amid Xbox 'Reset'
Avowed and The Outer Worlds developer Obsidian is reportedly also at risk of closure amid Microsoft’s “reset” of the Xbox business.
Scientists Were Puzzled for Years by Mysterious Seafloor ‘Crop Circles'
Divers discovered strange geometric formations on the ocean floor in 1995. It took until 2011 to find the tiny, poisonous architect behind them—and we're still unraveling why it builds them.
In Mojave Desert, startup JetZero builds novel plane to take on Airbus and Boeing
Inside a cavernous aircraft hangar in the Mojave Desert, JetZero is building a full-size demonstrator of what could be a 200-plus-seat jet, a lucrative market segment expected to be at the center of future plane strategies for Airbus and Boeing .
Science achievement is not a one-year event
Educational systems often encourage leaders to focus on immediate science achievement while science learning unfolds over many years.
Yankees news: Judge calls out “lack of focus”
The captain’s rebuke; illness strikes the clubhouse; Grisham in NJ; Goldschmidt left on bench in loss; Futures Game picks
Byron Donalds' front-runner wall grows with Blaise Ingoglia endorsement
Ingoglia joins James Uthmeier, Jim Boyd and Sam Garrison behind the Donald Trump-backed front-runner.
Global Health Program builds nurse leaders with broad worldview
A chance conversation at a high school reunion eventually led to a request for assistance from the president of Zambia for Kenneth P. Miller, PhD, MJ, RN, CFNP, FAAN, FAANP, associate dean for ambulatory services at The University of Texas at San Antonio School of Nursing. While catching up with a friar at his […]
You won’t be able to buy new PlayStation games on discs starting in 2028
It's is a massive step toward the dissolution of physical media in games, since PlayStation holds the biggest share of the console market.
ASU scientists unveil new methods to extract reliable truth from imperfect data
Scientists at Arizona State University are advancing how they interpret complex, imperfect data — challenging long-standing assumptions in fields ranging from imaging to cellular biology. In two papers published in Nature Communications and Proceedings of the National Academy of Sciences, the team introduces fundamentally new approaches to solving “inverse problems,” where researchers work backward from noisy observations to uncover the underlying reality.
Subnautica 2 studio Unknown Worlds' CEO resigns as Krafton agrees to pay $250m bonus
Krafton has settled its lawsuit with the former leadership team of Subnautica 2 developer, Unknown Worlds, and agreed t…
Federal Reserve Chair Warsh emphasizes political independence, signals focus on inflation
In remarks at a central bank conference in Sintra, Portugal, Warsh said that if businesses or households thought the Fed would accept inflation above 2%, “I guess they'd be disappointed. We're going to deliver price stability.”
Carolina’s School of Data and Information Sciences launches
In a campus message, Executive Vice Chancellor and Provost Magnus Egerstedt celebrated the “critical milestone” as the University builds on strengths in information, library and data sciences
Krafton Agrees to Pay ‘Subnautica 2’ Bonuses as Developer’s CEO Resigns
After being fired over a $250 million payout dispute and then reinstated, Unknown Worlds Entertainment boss Ted Gill is leaving again
Iowa's U.S. Senator Ernst holds final Small Business Expo
Iowa Senator Joni Ernst says a bill she co-sponsored has closed loopholes in two federal programs that award military contracts to small businesses that are engaged in research and development and technology. Ernst, a Republican from Red Oak, is chair of the U-S Senate Committee on Small Business and Entrepreneurship. “We’re really proud that we […]
Only the midwest saw US population growth in every state. Will new residents change its politics?
Lower costs in Indiana, Iowa, Kentucky and Ohio raise questions about whether Republican strongholds will shift
US cooking oil market shrinking due to Ice pressures on Latino households, Mazola owner says
Economic squeeze and anti-immigration raids have hit Hispanic communities, prompting people to shop online and reuse oil
How eggs became the latest campaign issue in Texas' Senate race
Republican Ken Paxton says his settlement holds producers accountable. Democrat James Talarico says Republicans still haven't lowered grocery bills.
MD lawmaker's historic journey unfolds in book that's part autobiography, part political memoir
Maryland lawmaker, Lily Qi, writes about her journey from China to the US and into state politics in a book that's part autobiography, part political memoir
Booze schmooze: The alcohol industry, frazzled by headwinds, wields its power behind the scenes
Demand for alcohol is declining. The industry is fighting harder and more creatively than ever against limits — and winning.
Algeria to vote in test of post-Hirak political landscape
Algeria holds legislative elections amid debates over reform, turnout and political stability.
Microsoft set to cut thousands of jobs next week, spanning Xbox, sales and consulting
Microsoft is preparing another round of layoffs, spanning Xbox, sales and consulting, as it holds down operating costs while pouring more than $100 billion into AI infrastructure.
Supreme Court upholds transgender sports bans: What to know and what’s next
The Supreme Court on Tuesday upheld state bans on transgender students playing on girls sports teams, delivering another blockbuster setback to trans youth and their families in a decision that is likely to sustain similar laws in about half of the nation.
Supreme Court upholds transgender sports bans: What to know and what’s next
The Supreme Court on Tuesday upheld state bans on transgender students playing on girls sports teams, delivering another blockbuster setback to trans youth and their families in a decision that is likely to sustain similar laws in about half of the nation.
Fox News Poll: Maine Senate race is tight, with concerns about both candidates
Susan Collins holds a slim 3-point lead over Graham Platner in Maine, but a 15-point enthusiasm gap among Democrats keeps the race competitive.
Supreme Court upholds birthright citizenship, rejecting Trump’s proposed limits
WASHINGTON (AP) — A divided Supreme Court on Tuesday upheld a broad conception of birthright citizenship, rejecting President Donald Trump’s executive order declaring that children born to people who are in the United States illegally or temporarily are not American citizens. The justices relied on a long-settled understanding of the 14th Amendment, adopted after the […]
Supreme Court upholds principle that almost all born on U.S. soil are American
If the court had struck down birthright citizenship and upheld President Donald Trump’s executive order, the ruling would have had sweeping political, economic and social ramifications.
SCOTUS protects girls in sports, upholds biological reality
A trans athlete keeps winning girls' state titles in California. The Supreme Court just made sure 27 other states don't have to allow it.
Viewpoint: We must support girls in outdoor science fields
Marilyn Marler writes, Studies show that girls start losing interest in science and math around middle school and, as a result, women are often underrepresented in these professional fields.
Gov. Little celebrates U.S. Supreme Court’s decision upholding protections for women’s sports
Boise, Idaho – Governor Brad Little commented today on the U.S. Supreme Court’s decision in Little v. Hecox. The ruling upholds Idaho’s ban on men participating in women’s sports. “Idaho was the very first state to ban men from participating in women’s sports with the passage of the Fairness
US Supreme Court upholds bans on transgender women in female school and college sports
It rules that states can ban transgender athletes from competing in women's and girls' sports.
Supreme Court upholds laws banning transgender females from school sports teams
The ruling could impact 25 other states with similar laws
Supreme Court upholds state laws banning transgender athletes
The Supreme Court on Tuesday issued a decision to uphold state laws barring transgender girls and women from playing on school athletic teams.
Supreme Court upholds laws banning trans athletes from women's sports
The 6-3 ruling upholds state laws in Idaho and West Virginia.
Supreme Court upholds bans on transgender athletes participating in women and girls' sports
Justice Brett Kavanaugh, who has long coached his daughters' and other girls basketball teams at school, wrote the court's majority opinion.
Supreme Court upholds state laws banning transgender girls and women from school sports
The Supreme Court upheld state laws banning transgender girls and women from school athletic teams on Tuesday.
Supreme Court upholds state bans at center of transgender sports debate
WASHINGTON – The Supreme Court upheld state bans on transgender athletes, a ruling with major implications for Arizona and 26 other states with laws restricting participation in school sports.
Supreme Court upholds state bans on transgender athletes in girls' and women's sports
Supreme Court Upholds Bans On Transgender Women In Sports
The ruling will impact laws in more than 25 states.
Supreme Court upholds state bans on transgender athletes in girls and women's sports
The ruling on a pair of separate cases from Idaho and West Virginia could carry far-reaching implications for transgender rights.
Supreme Court upholds state transgender sports bans
In the latest of a string of losses for LGBTQ rights, the high court allowed states to bar transgender athletes from girls’ and women’s sports.
US supreme court upholds laws excluding trans women from competing in female sports
Justices voted to overturn judgements issued by lower courts in favor of trans students who sued after being barred from competing in West Virginia and Idaho
What Botox, rat poison and venoms can teach students about science
New University of Nevada, Reno course builds scientific thinking skills for future science-related fields
Cara Delevingne confirms she and Amber Heard were romantically involved amid actress' Johnny Depp divorce
Model-actress Cara Delevingne confirms she and 'London Fields' costar Amber Heard were romantically involved amid actress' divorce from Johnny Depp.
Trump unloads after Supreme Court upholds late mail-in ballots in Mississippi
Trump slams Supreme Court ruling allowing late mail-in ballots, demands Congress pass the SAVE Act requiring voter ID and proof of citizenship.
Supreme Court says Fed's Lisa Cook can keep her job for now, but it upholds other Trump firings
The Supreme Court on Monday dramatically expanded presidential power, upholding President Donald Trump’s firings of the heads of independent federal agencies with one important exception, the Federal Reserve.
DMC Sinai-Grace holds 2nd annual health fair with free screenings, food, entertainment
DMC Sinai-Grace Hospital is taking patient care beyond the hospital walls and into the heart of the Detroit community.
DMC Sinai-Grace holds 2nd annual health fair with free screenings, food, entertainment
DMC Sinai-Grace Hospital is taking patient care beyond the hospital walls and into the heart of the Detroit community.
Wa-Hi junior Lars Sandven selected for prestigious national science camp
The residential summer camp provides academic and leadership experience in STEAM fields.
Passback finds new life for old sports equipment, equipping youth to take the field
Magdalen Sparrow grew up on St. Louis’ soccer fields chasing after stray balls and picking up lost water bottles to put in overflowing lost and found bins. Then known by her maiden name, Magdalen Pike, she went on to play D1 soccer at Southeast Missouri State University, accumulating a closet full of sports gear in […]
UK Political Angst Turned Foreigners Into Gilt Sellers in May
Foreign investors, long an anchor for the UK government bond market, turned net sellers of gilts in May as climbing yields failed to offset concern about the country’s political turbulence.
Jersey end perfect season with Cherry Godfrey Cup win
Jersey's women end a perfect season with victory in the Cherry Godfrey Cup.
Colorado’s regulations should address policy challenges only as truly needed
As Colorado approaches its 150th birthday, we should remember its first 100 years were characterized by repeated boom-and-bust economic cycles. Dependence on mineral extraction and agricultural commodity prices was subject to the volatility of these markets. In 1972, as I arrived in Denver with Ma Bell, 40,000 metro households were waiting for dial tone since […]
We turned 80-year-olds into trained health monitors to save lives and boost senior dignity
As a career geriatrician, I’ve long known that some of society’s finest minds are being underappreciated while living in senior communities. So I helped to develop a new health program to help put older adults on the watch as health monitors.
New Mexico Sports Hall of Fame 2025 inductees honored at banquet
Anita Maxwell, John Fields, and Miles Watters -- 3 of the 5 members of the class of 2025 -- were at the celebration.
‘Inner party turf wars’ hang over annual Florida Republican convention
Byron Donalds and state party chair Evan Power also detailed how they plan to frame Florida’s moderate Democratic candidates as progressives.
Austrian GP: George Russell holds off Max Verstappen to end winless streak and reinvigorate title bid
Lyles to take charge of Ultimate Championship entertainment
Noah Lyles has been announced as an Ultimate Star for the World Athletics Ultimate Championship, taking place from September 11-13 in Budapest, Hungary.Lyles, the dominant US sprinter who has won consecutive 200m golds at the past four World Championships, is locked in to compete at the inaugural edition of the new global championship. Lyles has earned automatic qualification into both the 100m and 200m by virtue of his podium-topping performances in those disciplines at the Paris 2024 Olympic Games and the World Athletics Championships Tokyo 25, respectively.
Sony’s New Blu-ray & DVD Player Upscales DVDs to Near-HD Quality - Bring Your Old DVDs To Life Again
In a time when streaming services continue to raise prices, fragment content libraries, remove content, and push intrusive ads, many households are rediscovering the reliability and ownership of physical DVDs and Blu-rays. Sony has answered this shift with the release of its latest affordable disc player: the Sony BDP-S1700U. Priced at just $114.99, this sleek […]
These tiny soil microbes could rescue crops from salty farmland
Researchers have discovered that beneficial soil bacteria give plants an unexpected survival advantage in salty soils. Instead of helping plants keep salt out, the microbes stimulate the production of lignin, a natural compound that strengthens roots and makes plants more resilient. Greenhouse and field tests showed healthier plants and higher yields in salty conditions. The findings could lead to bio-based treatments that help farmers grow crops on land once considered too salty for agriculture.
Costs of Iran war will linger despite conflict's end, experts say
The effects of the war and other factors driving inflation are likely to stick around for months, experts say, presenting an ongoing challenge to American households.
‘Photo I.D. should be at the core.’ Rep. Byron Donalds on polling that Americans favor requiring a photo I.D. to vote
Stephenson Business Center highlights local vendors, gives back to community
The Stephenson Business Center holds a community event Saturday with dozens of vendors and some giveaways for area residents.
Illinois 250: What we’ve invented, innovated, created and manufactured
Illinois builds things. We invent and innovate, too — everything from the Pullman car to plastic party cups.
Trump admin rule puts reproductive health care for 160K Pa. patients at risk, lawsuit says
Spotlight PA is an independent, nonpartisan, and nonprofit newsroom producing investigative and public-service journalism that holds power to account and...
Jeffries Faces Steep Test as Far Left Builds Strength in Congress
The victories of Darializa Avila Chevalier and other anti-establishment candidates are changing the face of House Democrats, posing a challenge for their leader.
Trump-endorsed candidates hold nearly perfect record in GOP primaries
No modern president wields party influence the way Donald Trump does, experts say, but it could be costly to his party in the 2026 midterms.
Tourism tax dollars to drive $25M makeover of John R. Jones Sports Complex in Pensacola
PENSACOLA, Fla. -- The John R. Jones Sports Complex will soon undergo a makeover. When it's complete, it is expected to be one of the premiere athletic fields i
Nebraska Hispanic Chamber of Commerce holds networking event for Omaha businesses
Watch: Omaha business leaders met at Mexico's consulate to network with the Nebraska Hispanic Chamber of Commerce
What your sleep schedule says about your health
From the time you naturally wake up to how long you actually sleep, your schedule holds clues about your heart, hormones, mental health, and longevity
Black Health and Wellness Association holds event to provide healthcare options in North Omaha
Watch: The Black Health and Wellness Association hosted a community night to provide healthcare resources for North Omaha residents.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
‘Turf Tank’ robot elevates Oregon sports fields
The Oregon Youth Soccer Association is taking advantage of some new technology to keep its fields game day ready.
The Big Summer Preview – New Starter Sets and ready painted terrain
Dive into Warhammer 40,000, and fight on the battlefields of Armageddon with new terrain kits.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
REV Entertainment Announces Enhanced 2027 College Baseball Series Slate
REV Entertainment announces the 2027 College Baseball Series, featuring seven tournaments across five locations. Find full team fields, dates, and additional info here!
Apolosign Digital Calendar and Portable TV for Family Organization and Home Entertainment
NEW YORK, June 25, 2026 (GLOBE NEWSWIRE) -- Apolosign, a smart family display brand serving more than one million households worldwide, today an...