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“Breaking Bad” star RJ Mitte’s sister pays tribute to late brother: ‘I just lost my other half’

Lacianne Carriere shared photos and videos from her brother’s life on Instagram.

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Oct 26 • 9:27 AM EDT • Entertainment • yahoo.com
Arsenal 29yo very keen to return to England squad

Ben White is keen to return to the England squad next month, and he’s enjoying finally being able to share his minutes with Jurrien Timber.Photo by Maurizio Lagana/Getty ImagesFor a long time at Ars...

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Oct 26 • 9:05 AM EDT • Sports • sports.yahoo.com
Some iPhone Duo Models Are Breaking. iFixit’s Teardown Might Explain Why

The repair company iFixit released its repairability rating for Apple’s very first foldable iPhone. It comes as users report a wave of cracked-screen issues.

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Oct 26 • 9:00 AM EDT • Technology • wired.com
Sandra Birchmore's mental health counselor to resume testimony in the trial of Matthew Farwell

Diala Alkhalil, Birchmore's mental health counselor, is expected to continue testifying after first taking the stand Friday.

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Oct 26 • 8:50 AM EDT • Health • boston.com
Britain Politics

Britain's Prime Minister Andy Burnham speaks as he hosts a "Rough Sleeping Summit" in Downing Street in central London, Monday, Oct. 26, 2026. (Carlos Jasso/Pool Photo via AP)

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Oct 26 • 8:43 AM EDT • Politics • postregister.com
Business First: Q3 Earnings Snapshot

(AP) — Business First Bancshares, Inc. (BFST) on Monday reported third-quarter profit of $24.

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Oct 26 • 8:40 AM EDT • Business • finance.yahoo.com
BRITAIN-POLITICS

Britain's Prime Minister Andy Burnham speaks as he hosts a "Rough Sleeping Summit" in Downing Street in central London, Monday, Oct. 26, 2026. (Carlos Jasso/Pool Photo via AP)

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Oct 26 • 8:40 AM EDT • Politics • postregister.com
Indiana's New Small Business Program: From Policy to Opportunity

Indiana’s approach to state contracting underwent a significant transformation this summer. Following an opinion from Attorney General Todd Rokita questioning the constitutionality of race- and sex-based contracting preferences, Gov. Mike Braun suspended the state’s Supplier Diversity Program and directed the creation of a new

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Oct 26 • 8:33 AM EDT • Business • indianachamber.com
Purdue and Accenture: A model for applied partnership

Artificial Intelligence is reshaping every industry. Find out how Purdue and Accenture are working together to prepare Indiana’s workforce and students in Purdue’s Mitch Daniels School of Business for an AI-powered future.

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Oct 26 • 8:09 AM EDT • Business • ibj.com
'Beetlejuice' star Ryan Stajmiger talks carving pumpkins and scaring

The national touring company's musical take on the classic Michael Keaton begins a Hobby Center run Nov. 3.

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Oct 26 • 8:00 AM EDT • Entertainment • houstonchronicle.com
PHOTO STORY: Explora blends science and the spooky for Halloween ‘Adult Night’

Getting into the Halloween spirit, Explora Science Center and Children’s Museum hosted an Adult Night on Oct. 16. Explora created an event for audiences 18 and over to enjoy a spooky, Halloween-themed night filled with crafts and events for adults to have fun. Costumes were encouraged, and many guests showed up in a variety of unique outfits.

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Oct 26 • 8:00 AM EDT • Science • dailylobo.com
Alex Cora opens up about leaving the Red Sox

| WEEI 93.7

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Oct 26 • 7:59 AM EDT • Sports • audacy.com
Suffolk County expands testing for 'forever chemicals' in private wells in Orient and Cutchogue

Discover the role of PFAS testing in safeguarding health as Suffolk County tests private wells for forever chemicals.

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Oct 26 • 7:06 AM EDT • Health • northforksun.com
Worrisome chemical found in SF Bay Area, Santa Cruz creeks

A toxic compound has been found at worrisome levels in some watersheds in California.

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Oct 26 • 7:00 AM EDT • Science • sfchronicle.com
Liza Minnelli bombed in many movies. So why do people still love her?

ASK MICK LASALLE: The Chronicle movie critic emeritus answers questions about Liza Minnelli, Dolly Parton and his favorite documentaries, with 11 films he says are worth seeking.

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Oct 26 • 7:00 AM EDT • Entertainment • sfchronicle.com
These are the best local businesses in Columbia for 2026, Nextdoor neighbors say

The 2026 Fave Award Winners on Nextdoor were finally revealed. Columbia residents said these are the best businesses in the city.

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Oct 26 • 6:02 AM EDT • Business • thestate.com
Trump’s D.C. hotel is gone. Mar-a-Lago is now a GOP campaign cash magnet.

Republican campaigns, party committees and PACs have spent nearly $3 million at Trump businesses since his return to office, a Post analysis finds.

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Oct 26 • 6:00 AM EDT • Politics • washingtonpost.com
Stocks and ETFs to tap into Wall Street's hot theme: Quality

"We believe we are in a backdrop today that is conducive to quality themes outperforming," Piper Sandler says.

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Oct 26 • 5:15 AM EDT • Business • businessinsider.com
Check out our favorite horror films, shows filmed in North Carolina

In honor of Halloween, here are 6 of the best horror films shot in North Carolina, plus a few TV options and more.

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Oct 26 • 5:04 AM EDT • Entertainment • shelbystar.com
Mental health event aims to support those who serve and protect

“Resilience: From Service to Strength” is an Oct. 27 Rockledge event focused on mental health for veterans, military and first responders.

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Oct 26 • 5:04 AM EDT • Health • floridatoday.com
The 4 stages of women’s heart health: Experts present new framework

New guidance is intended to help girls and women — and their doctors — recognize four distinct phases in heart health.

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Oct 26 • 5:00 AM EDT • Health • statnews.com
Best political cartoons for Oct. 18-24 (opinion)

Cartoons of the week for Oct. 18-24 brace for the arrival of Halloween and mid-term elections.

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Oct 26 • 4:30 AM EDT • Politics • ctinsider.com
Once a childhood patient at Jordan Health, soon the CEO

Natasha Jackson told the Democrat and Chronicle her vision is that Jordan Health is seen by residents 'as that partner that they can count on.'

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Oct 26 • 4:01 AM EDT • Health • democratandchronicle.com
Banc of Cal Expands to Private Banking

Los Angeles is a hotbed of established and budding personal wealth, and Brentwood-based Banc of California has thrown its hat into the ring to service

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Oct 26 • 3:01 AM EDT • Business • labusinessjournal.com
Psychology says children who carry the same toy from room to room may be seeking more than entertainment

it offers familiarity, comfort and a sense of security as they navigate an unfamiliar or overwhelming world.

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Oct 26 • 1:41 AM EDT • Entertainment • timesofindia.indiatimes.com
How to Manage Symptoms of Heart Failure

(Feature Impact) Americans are facing a growing health challenge, with 1 in 4 adults at risk of heart failure, according to the Heart Failure Society of America. Additionally, approximately 6.7 million U.S. adults who are 20 years old or older are currently living with heart failure, and that number is projected to reach 8.7 million by 2030. googletag.cmd.push(function() { googletag.display('JGFI_Article_300x250'); }); Managing heart failure is a significant expense to the U.S. healthcare system, costing the nation approximately $40 billion in 2020 and expected to increase to approximately $142 billion a year by 2050.If you (or a loved one) are living with the condition, consider these tips to help manage it.Adhere to the Treatment and Follow-Up PlanOngoing outpatient care is important when managing heart failure. Understand the treatment plan provided by your healthcare team, make diet and lifestyle changes, take medications as directed and keep recommended follow-up appointments.Pay attention to changes in symptoms and communicate with your healthcare provider if treatment does not seem to be working as expected. If their conditions are left unmanaged, patients can experience a range of heart-failure-related symptoms such as shortness of breath, fatigue, buildup of fluid and more.Understand Challenges with Diuretic TreatmentDiuretics help the body remove excess fluid and are commonly used to treat swelling, or edema, associated with heart failure. Your provider may try different diuretics, sometimes referred to as “water pills,” to manage your heart failure symptoms. However, intravenous (IV) diuretic therapy may be required for some patients if symptoms continue.Ask About Treatment Options Before IV Care Is NeededFor some adults, a healthcare provider may consider recommending an at-home, non-oral diuretic option prior to escalating to IV therapy.For example, ENBUMYST™ (bumetanide nasal spray) is a prescription diuretic used in adults to treat edema associated with congestive heart failure. It’s administered as a nasal spray for short-term use to manage excess fluid with the goal of transitioning to oral diuretic therapy when appropriate.Talk with your healthcare provider to learn more and visit enbumyst.com. Read the full Prescribing Information and Patient Information.Photo courtesy of Shutterstock googletag.cmd.push(function() { googletag.display('JGFI_Article2_300x250'); }); Important Safety InformationWhat is ENBUMYST?ENBUMYST is a prescription medicine used in adults to treat swelling caused by excess fluid in the body (edema) from congestive heart failure, liver disease, and kidney disease.What is the most important information I should know about ENBUMYST?ENBUMYST is a diuretic that helps your body remove fluid. Losing too much fluid can cause dehydration, low blood volume, and increase the risk of blood clots. Blood abnormalities may include decreased salts (electrolytes), and increased nitrogen, glucose and uric acid. The risk of these abnormalities is higher in elderly people, those using higher doses, or those who do not get enough electrolytes by mouth.You should not use ENBUMYST if you have severe electrolyte loss. Tell your healthcare provider if you experience unusual thirst; dizziness or lightheadedness; weakness or tiredness; fast heart rate; dry mouth or tongue; sudden pain; redness or swelling in your joints; pain, swelling, redness, or warmth in your leg; shortness of breath or fast breathing; high blood sugar; dark urine; pale, tight, cool or clammy skin; muscle cramps; confusion.Do not use ENBUMYST if you have low or no urine production or are allergic to bumetanide or to any of the ingredients in ENBUMYST.Before using ENBUMYST, tell your healthcare provider if you have low electrolytes, are on a low-salt diet, have diarrhea, diabetes, nasal problems such as a runny or stuffy nose or polyps, a history of nasal injury or surgery, are or plan to become pregnant, are or plan to breastfeed.Tell your healthcare provider about all the medicines you take, including prescriptions, over-the-counter medicines, vitamins, and herbal supplements.ENBUMYST may cause serious side effects, such as worsening kidney function and ringing in the ears or hearing loss.The most common side effects of ENBUMYST include dehydration, headache, muscle cramps, dizziness, low blood pressure, nausea, and abnormal brain functioning with certain liver problems.These are not all the possible side effects of ENBUMYST. Talk to your healthcare provider for more information.Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.US-ENBU-2600110 googletag.cmd.push(function() { googletag.display('JGFI_Article3_300x250'); });

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Oct 26 • 1:00 AM EDT • Health • journalgazette.net
Local businesses weather the effects of international Geneva cuts

For nearly two years, restaurants, hotels, and other parts of the local economy have grappled with the effects of international Geneva job and budget cuts, particularly around the Nations quarter. Two publicly backed studies are now seeking to quantify the losses.

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Oct 26 • 12:47 AM EDT • Business • genevasolutions.news
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High school sports roundup for Oct. 23-24, 2026

Friday, Oct. 23 Football Meadowdale defeated Lynnwood 48-0 The Meadowdale Mavericks jumped out to a 41-0 halftime lead en route to a 48-0 shutout win over the Lynnwood Royals. The […]

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Oct 26 • 12:28 AM EDT • Sports • myedmondsnews.com
West Virginia Senate District 2 race pits political newcomers Heaney, Claypole

With West Virginia Sen. Charlie Clements deciding not to run again in this year’s election, two political newcomers are vying to take over the seat representing

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Oct 26 • 12:27 AM EDT • Politics • wtov9.com
Dana White Outlines How Movsar Evloev Gets Another Title Shot

UFC president Dana White outlined how featherweight fighter Movsar Evloev could get another title shot at 145 lbs.Evloev was 20-0 in MMA and 10-0 in the UFC heading into UFC 333, but he suffered a brutal second-round knockout loss against UFC featherweight champion Alexander Volkanovski in a failed bid to become the promotion’s new 145 […] The post Dana White Outlines How Movsar Evloev Gets Another Title Shot appeared first on HEAVY.

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Oct 25 • 11:43 PM EDT • Sports • sports.yahoo.com
Daniel Cormier Says Alexander Volkov Should Get UFC Title Shot

UFC commentator Daniel Cormier says that Alexander Volkov deserves to be next in line to fight for the UFC heavyweight title. Volkov — who turned heads this week with a viral clip of him asking UFC president Dana White what he has to do to get a title shot — defeated Rizvan Kuniev at UFC […] The post Daniel Cormier Says Alexander Volkov Should Get UFC Title Shot appeared first on HEAVY.

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Oct 25 • 11:30 PM EDT • Sports • sports.yahoo.com
Ewa Beach shooting survivor overcomes another health scare

Three years after surviving a gunshot to the head, Richianna DeGuzman is heading back to rehab following a week-long stay in the ICU.

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Oct 25 • 11:24 PM EDT • Health • hawaiinewsnow.com
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Earnings to watch: Caesars Entertainment (CZR) reports Q3 results tomorrow

Hotel and casino entertainment company Caesars Entertainment (NASDAQ:CZR) will be reporting earnings this Tuesday after market close. Here’s what to expect. ...

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Oct 25 • 11:08 PM EDT • Entertainment • stockstory.org
Earnings to watch: Caesars Entertainment (CZR) reports Q3 results tomorrow

Hotel and casino entertainment company Caesars Entertainment NASDAQ:CZRwill be reporting earnings this Tuesday after market close. Here’s what to expect.Caesars Entertainment beat analysts’ revenue expectations last quarter, reporting revenues of $2.99 billion, up 3% year on year. It was a softer q…

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Oct 25 • 11:08 PM EDT • Entertainment • tradingview.com
Why Fulton County is at the center of Georgia politics

Over the past decade, Georgia has become a closely watched swing state thanks to Fulton County's emergence as a political powerhouse—and the focal point of Donald Trump’s efforts to challenge his 2020 election loss—but its influence wasn’t always so pronounced.

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Oct 25 • 10:56 PM EDT • Politics • atlantamagazine.com
Science behind virga, rain or snow that never reaches the ground

Science behind virga; rain or snow that never reaches the ground

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Oct 25 • 10:46 PM EDT • Science • kq2.com
Mohun Bagan vs Chennaiyin FC in ISL Wrestling World Championships continue: Indian Sports LIVE, October 26

Here are all the updates from Indian sports on October 26, 2026.

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Oct 25 • 10:35 PM EDT • Sports • espn.com
Arkansan visits Washington, supports push to improve female veterans’ healthcare

WASHINGTON -- An Arkansas veteran was part of a recent push urging Congress to consider legislation to improve healthcare for women veterans.

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Oct 25 • 10:00 PM EDT • Health • arkansasonline.com
San Anselmo businesses prepare for potential El Niño flooding as winter approaches
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Oct 25 • 9:33 PM EDT • Business • cbsnews.com
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The best apps for tracking your reading and discovering new books

There are many apps that are designed to help you track your reading and discover new books, so we compiled a list of some of the best ones.

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Oct 25 • 9:10 PM EDT • Technology • techcrunch.com
Corpus Christi Museum of Science and History turns Halloween into a hands-on learning experience for kids

The Corpus Christi Museum of Science and History made Halloween educational with hands-on activities, experts and a Mad Science Show.

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Oct 25 • 8:48 PM EDT • Science • kristv.com
IN GOOD HEALTH: Preparing for respiratory illness season

By Leanna Coy, FNP-BC As temperatures begin to cool and the holiday season gets underway with Halloween this month, it’s time to prepare for fall and winter respiratory illnesses. As we…

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Oct 25 • 8:45 PM EDT • Health • tillamookcountypioneer.net
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APTOPIX Brazil Election

Supporters of President Luiz Inacio Lula da Silva celebrate after he won the presidential runoff in Rio de Janeiro, Sunday, Oct. 25, 2026. (AP Photo/Lucas Landau)

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Oct 25 • 8:28 PM EDT • Business • telegraphherald.com
Attackers kill nurse, severely injure health worker responding to Ebola case in eastern Congo

The World Health Organization reports that a nurse has been killed and a health worker severely injured in an attack while responding to an Ebola alert in Congo. This attack, which occurred on...

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Oct 25 • 8:01 PM EDT • Health • seattlepi.com
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Kings’ Mogbo Wants To Set Defensive Tone in G League

Armed with a 7-foot-2 wingspan and relentless hustle, the two-way forward aims to spark Stockton’s defense through gritty rebounding and elite shot-contesting while eyeing a permanent NBA promotion.

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Oct 25 • 7:36 PM EDT • Sports • sports.yahoo.com
Edmonds Serves spotlight: Verdant Health Commission

The City of Edmonds is shining the spotlight on those recognized through Edmonds Serves, an initiative honoring all those who serve our community. This week it’s Deana Knutsen of the […]

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Oct 25 • 7:04 PM EDT • Health • myedmondsnews.com
Race Results: 2026 NASCAR Cup Series YellaWood 500 at Talladega

Kyle Larson took a thrilling win in a wild last-lap rally that led to a photo-finish with William Byron, his Hendrick Motorsports teammate. Larson, who was eighth heading down the backstretch of the final lap, had everything go his way ahead of him, as he sliced and diced his way back to the front. Ricky […] The post Race Results: 2026 NASCAR Cup Series YellaWood 500 at Talladega appeared first on TobyChristie.com.

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Oct 25 • 6:46 PM EDT • Sports • sports.yahoo.com
Families celebrate Halloween with a side of science at Nature Museum

The Peggy Notebaert Nature Museum invited families to its annual BOO-seum Bash Sunday, with animal encounters, hands-on activities and plenty of Halloween fun.

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Oct 25 • 6:42 PM EDT • Science • wgntv.com
With flu season off to an unusually early start, here's what doctors are seeing

It's not even Halloween yet, but doctors say flu season off to an unusually early start.

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Oct 25 • 6:39 PM EDT • Health • nbcchicago.com
Bob on Business: For Fort Worth’s office market, the summer was hot

Also, aviation acquisition and Grapevine company plans big expansion.

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Oct 25 • 6:01 PM EDT • Business • fortworthreport.org
Over 300 students learn science and technology at CCSD Family STEM Day

Over 300 students learned about science and technology industries at the Clark County School District Magnet Schools Family STEM Day on Saturday.STEM Day as he

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Oct 25 • 6:00 PM EDT • Science • news3lv.com
Bengals Shut out in Disastrous First Half vs Ravens

The Cincinnati Bengals are off to a first half they’d like to forget. Cincy trails the Baltimore Ravens 13-0 in Baltimore.The story has been the Cincinnati Bengals’ defense which has been struggling against this Ravens offense.The Ravens got off to a hot start as Zay Flowers took a 48-yard pass to the house from backup […] The post Bengals Shut out in Disastrous First Half vs Ravens appeared first on HEAVY.

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Oct 25 • 5:33 PM EDT • Sports • sports.yahoo.com
Kenilworth's David Brearley 2026 Homecoming Photo Album

KENILWORTH, NJ – The Homecoming Dance was held on Friday, Oct. 16, and students were filled with energy and excitement as they left for the annual occasion held at David Brearley.To preserve the...

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Oct 25 • 4:48 PM EDT • Entertainment • tapinto.net
Historic Texas theater sold to New York wellness business

Not everyone is happy about this development.

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Oct 25 • 4:31 PM EDT • Business • chron.com
Frisco Muslims vote in Texas midterms marked by anti-Islam rhetoric

Texas politicians have campaigned on banning Shariah this cycle. Muslim voters are encouraging their fellow believers to get involved in politics.

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Oct 25 • 4:02 PM EDT • Politics • dallasnews.com
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Photo: Jude Bellingham’s head-turning new boots for Barcelona showdown

Real Madrid star Jude Bellingham has on Sunday evening provided a look at the head-turning footwear that he is set to make use of in El Clásico.The latest edition of Spanish football’s most bitter ...

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Oct 25 • 3:45 PM EDT • Sports • sports.yahoo.com
Des Moines bishop says White House 'exploited' visit for politics

Bishop William Joensen was one of several invited to the White House for a private meeting they say is being used for "partisan political purposes."

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Oct 25 • 3:28 PM EDT • Politics • desmoinesregister.com
The Politics of Heaven ~ The Imaginative Conservative

The key to understanding Thomas More’s generous dedication to the real but limited good he could do on earth is, as Frank Mitjans makes clear, that More’s constant contemplation of God was the source of his boundless care for the souls surrounding him. Thomas More’s Vocation, by Frank Mitjans

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Oct 25 • 3:20 PM EDT • Politics • theimaginativeconservative.org
New Braunfels Wurstfest ranks No. 1 in Southern Living list

Southern Living ranks this Texas Oktoberfest ahead of Fredericksburg.

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Oct 25 • 3:18 PM EDT • Entertainment • mysanantonio.com
Retailers in Paris React to Protests [PHOTOS]

Retailers Assess Cost of Lost Business After Second Round of Protests

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Oct 25 • 3:08 PM EDT • Business • wwd.com
After arts festival, San Francisco's Mid-Market businesses look for signs of a turnaround
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Oct 25 • 2:54 PM EDT • Business • cbsnews.com
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Queen of Halloween Heidi Klum teases costume with mysterious image

“What’s my costume?,” the model asked fans alongside a strange close-up photo.

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Oct 25 • 2:37 PM EDT • Entertainment • yahoo.com
Google's privacy policy now has a loophole for using your Gmail and Photos data in ads

The change sits in Google's updated privacy policy, which took effect on October 16 and was first spotted by Android Authority. The policy has long said, "We...

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Oct 25 • 1:33 PM EDT • Technology • techspot.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...

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Oct 25 • 1:16 PM EDT • Entertainment • stamfordadvocate.com
Clatsop County health inspections for September

Clatsop County health inspectors recently completed a round of restaurant inspections that yielded overwhelmingly positive results for most local eateries. But one Seaside establishment received a temporary closure after receiving […]

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Oct 25 • 1:10 PM EDT • Health • dailyastorian.com
'Sound of Music' star Julie Andrews spotted in rare Hamptons outing weeks after turning 91

Julie Andrews, 91, was photographed in the Hamptons wearing a purple raincoat and pink sunglasses in a rare public outing in the coastal city.

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Oct 25 • 1:00 PM EDT • Entertainment • yahoo.com
Photographer and medical professionals connect science and art during panel discussion

In 2020, the world was put on hold because COVID-19 began claiming the lives of people all over the globe. When a vaccination for the illness was finally made public in 2021, being vaccinated became highly politicized. Instead of focusing on the emotional reactions that people had toward the vaccine, artist Linda Alterwitz was more...

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Oct 25 • 12:14 PM EDT • Science • thesunflower.com
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Americans have a grief problem we still call a mental health problem

OPINION — Americans have become much better at talking about mental health. We have learned words such as trauma, post-traumatic stress disorder, depression, anxiety, burnout, compassion fatigue and moral injury. That vocabulary matters.

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Oct 25 • 12:00 PM EDT • Health • yourvalley.net
Trick-or-treaters descend on Callow Avenue for Calloween

Photos from Charleston Business District's annual Calloween event on Saturday, Oct. 24. ·

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Oct 25 • 11:57 AM EDT • Business • kitsapsun.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Xbox Asked for $800 Million After Netflix Offered $500 Million for Game Adaptation Rights

Netflix offered Xbox $500 million for seven years of exclusive film and TV rights, and Xbox countered with $800 million, Puck's newsletter…

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Oct 25 • 11:17 AM EDT • Entertainment • northeasttimes.com
Rumored Lucia Actress Goes Viral After Dodging Swarm of GTA 6 Comments During Livestream

Manni L. Perez, the actress long rumored to be playing Lucia in GTA 6, has gone viral after dodging a swarm of comments from Grand Theft Auto fans during a recent livestream.

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Oct 25 • 11:14 AM EDT • Technology • ign.com
Three Days Grace in San Antonio: What to know

The Canadian rockers are bringing their Alienation Tour to town. Here are the details on tickets, parking and more.

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Oct 25 • 11:00 AM EDT • Entertainment • expressnews.com
AI-generated video heats up suburban Texas political clash

Fort Bend County has seen plenty of controversy at its highest levels.

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Oct 25 • 10:57 AM EDT • Politics • chron.com
What Chelsea Did Wrong vs Tottenham

After a stellar run following the international break, things came crashing down for Chelsea as they lost 2-0 to Tottenham Hotspur at the weekend. This marked an extremely rare defeat at Stamford Bridge to the Lilywhites, a crack in a strong record of home wins that has left fans reeling. In this, we will be …

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Oct 25 • 10:54 AM EDT • Sports • sports.yahoo.com
Modders Unlock GeForce RTX 20, 30 And 40 GPUs For Up To 2X Compute Gains

The compute barrierbbetween NVIDIA RTX Pro GPUs and NVIDIA GeForce GPUs has finally been breached.

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Oct 25 • 10:51 AM EDT • Technology • hothardware.com
NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say

A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…

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Oct 25 • 10:20 AM EDT • Business • pilotonline.com
Science Snapshots: October 25, 2026

Three key science updates in one minute: Starry Night’s dawn matched to Jul 22, 1889; cold boosts lifespan via BH2/BH4; cluster similar-buildings cools cities.

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Oct 25 • 9:40 AM EDT • Science • thehindu.com
'All INdiana Politics': Engling, Ballard clash over restoring credibility to Indiana Secretary of State Office

INDIANAPOLIS — On Sunday’s edition of “All INdiana Politics,” Government Reporter Garrett Bergquist sat down with two candidates who are running for secretary of state, Republican Max Engling and independent Greg Ballard. Both candidates outlined contrasting approaches to restore credibility to an office plagued by controversy under outgoing Secretary Diego Morales. They both presented different […]

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Oct 25 • 9:30 AM EDT • Politics • wishtv.com
Business co-owner kills man ‘acting irrationally’ outside Zumba class, NC police say

The business co-owner was carrying a firearm, Spindale police say.

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Oct 25 • 9:12 AM EDT • Business • charlotteobserver.com
Will there be VAR for Fleetwood Town vs Arsenal?

The EFL have confirmed the match official appointments for the upcoming round of League Cup fixtures, including Arsenal’s trip away to Fleetwood Town.Photo by George Wood/Getty ImagesThe EFL have co...

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Oct 25 • 9:05 AM EDT • Sports • sports.yahoo.com
Names in the News: People shaping the future of Lake Area business

The Sculptry promotes staff The Sculptry, Southwest Louisiana’s premier medical aesthetics clinic, has expanded its leadership team with the announcement of new positions for key staff members. Amber Pauley, RN, […]

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Oct 25 • 8:23 AM EDT • Business • americanpress.com
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Arsenal squad & fixtures for the 2026 Messi Cup

The 2026 Messi Cup kicks off on Sunday, with Arsenal’s squad and fixture list for the tournament now confirmed.Photo by Elsa/Getty ImagesThe Arsenal u16s will take part in the Messi Cup this year, w...

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Oct 25 • 8:05 AM EDT • Sports • sports.yahoo.com
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Photos: Entertainment | Saints vs. Steelers

Check out the entertainment photos from the New Orleans Saints game against the Pittsburgh Steelers for Week 7 of the 2026 NFL season on Oct. 25, 2026 at the Stade de France featuring Burna Boy.

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Oct 25 • 8:00 AM EDT • Entertainment • neworleanssaints.com
Scientists Trapped an Antimatter Particle for Months to Study Its Secrets

These elusive and reactive particles have been challenging to hold on to and even more challenging to study, but a new method paves the way for tests on the differences between matter and antimatter.

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Oct 25 • 8:00 AM EDT • Science • wired.com
How whimsical Hands Gallery became a fixture in downtown SLO for 35 years

The popular shop offers a curated mix of local art, crafts, gifts and more on Higuera Street.

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Oct 25 • 8:00 AM EDT • Business • sanluisobispo.com
Selected Shots Sunday: Women’s Sports & Margo Mania!

This week’s photos feature soccer, volleyball and softball— EVERYONE WATCHES WOMEN’S SPORTS

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Oct 25 • 7:00 AM EDT • Sports • sports.yahoo.com
What we learned about our politics in the 2026 Texas elections

From the governor's race to local offices, the culture wars gave way to public education and property taxes.

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Oct 25 • 6:30 AM EDT • Politics • dallasnews.com
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Why Mikel Arteta is right about Max Dowman

Mikel Arteta has faced some pushback on his recent comments about Max Dowman, but the Arsenal manager was right to suggest that what the 16-year-old is doing is unique.Photo by Julian Finney/Getty Ima...

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Oct 25 • 6:20 AM EDT • Sports • sports.yahoo.com
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Apple CarPlay and Android Auto Make Your Phone Hot. Here’s How to Keep It Cool

Powering a car dashboard is more demanding on your handset than you might think. These tips will save battery life and help your phone chill out.

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Oct 25 • 6:15 AM EDT • Technology • wired.com
Amendment 87 can help support Colorado health care; no to tax increases; and more (Letters)

Amendment 87 gives Colorado a way to respond to our health care affordability crisis. New income tax revenue would be set aside for health care, K-12 public schools, and early child care, with an annual independent audit. For 97% of…

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Oct 25 • 6:00 AM EDT • Health • dailycamera.com
Cosmic 'seagull' locks eyes with the Vera C. Rubin Observatory in long-awaited test image — Space photo of the week

Stare into the transfixing eye of the "Seagull Nebula" in this newly-released test image from the visionary Vera C. Rubin Observatory.

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Oct 25 • 6:00 AM EDT • Science • livescience.com
The Political Upstarts That May Decide Israel’s Election

The upcoming Israeli election may be decided by two small parties that didn’t even exist a few months ago.

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Oct 25 • 6:00 AM EDT • Politics • newyorker.com
Guest Commentary: How anti-Muslim politics endangers every Floridian

The political caricature of Muslims as a national security threat bears little resemblance to the reality that Floridians are living, working, and raising families in peace with nearly half a million Muslims woven into the fabric of the state.

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Oct 25 • 5:30 AM EDT • Politics • orlandosentinel.com
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We Linked 150 of Ikea’s $10 Speakers to Make a Wall of Sound

WIRED attempts what even the Swedish brand hasn’t: making a sonic monolith using scores of the cheapest Bluetooth speakers on the market. Can you have too much of a small thing?

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Oct 25 • 5:00 AM EDT • Technology • wired.com
Snap a daily joy photo, snack on pumpkin seeds and try this logic puzzle — plus 5 more health tips to help you have a great week

Health hacks for the week ahead — including how walking can help get you out of a rut.

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Oct 25 • 5:00 AM EDT • Health • health.yahoo.com
Business briefs: Harry Reid airport completes $71 million baggage upgrade

In Terminal 1, the work included upgrades to eight baggage carousels, replacement of eight others, new conveyors and new carousel columns with LED screens. In Terminal 3, the project upgraded the computer hardware and software that control the baggage system …

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Oct 25 • 5:00 AM EDT • Business • lasvegassun.com
Today’s Papers – Lazio fly high, Roma comeback, furious Allegri

La Gazzetta dello SportFantastic draw.Crazy 3-3 between Napoli and Roma. Allegri was sent off; it was a fury.Super hot headLazio, a night as queen: +3 Inter; catching up is on the tableMilan: Cardinal...

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Oct 25 • 4:40 AM EDT • Sports • sports.yahoo.com
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Guest opinion: Partisan politics don’t belong in Montana’s courtrooms

As retired district court judges who worked in courtrooms across Montana, we know there is no Democratic or Republican way to handle the everyday court cases Montanans face. That’s why we support Constitutional Initiative 132 to keep our judicial elections nonpartisan.

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Oct 25 • 3:00 AM EDT • Politics • dailyinterlake.com
Who Did It? ‘Clue’ National Tour Brings Murder-Mystery Comedy to Penn State

Was it Professor Plum? Mrs. Peacock? Maybe Colonel Mustard? Penn State audiences can try to solve the mystery for themselves when the touring stage

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Oct 25 • 2:45 AM EDT • Entertainment • statecollege.com
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