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Abby Phillip on suggestions Vance being an Iran fall guy: ‘where you at Marco Rubio?’
A daily probiotic may help relieve depression and anxiety
A small clinical trial suggests that probiotics may offer a surprising mental health boost for older adults with depression. Seniors who took a daily probiotic alongside their regular antidepressant treatment experienced slightly greater improvements in depression and anxiety symptoms than those who received a placebo.
Building Scientists in the AI Era
Stevens Institute of Technology’s newly launched AI in Biology and Chemistry Community helps students explore AI’s role in health care, biotech and ed-tech careers.
Cell and gene therapy's next challenge is not the science, it's everything else
The field's foundational biology is no longer the limiting factor. What comes next depends on whether the industry can build the manufacturing, commercial, and clinical infrastructure to match what the science already knows how to do.
Play Chaos Cubed Today
Chaos Cubed has landed in Minecraft! Explore a striking cave biome filled with bubbling sulfur pools, build with sulfur and cinnabar, and discover the sulfur cube’s curious appetite for blocks! From bouncing and sliding to explosive surprises, this unpredictable mob unlocks exciting new ways to build, compete, and survive. Play Chaos Cubed today in Minecraft!
How a biotech turned a trial failure into an AI model
In this edition of STAT Health Tech: How a biotech startup turned a failed clinical trial into an AI model, and more.
Financing, regulatory concerns stall SunGas’ Louisiana biofuels ambitions
SunGas Renewables has halted development of its Beaver Lake Biofuels Project near Alexandria, ending plans for a major renewable fuels facility that would have converted sustainably sourced wood fiber into low-carbon methanol, 10/12 Industry Report reports. The project was expected to produce more than half a million metric tons of methanol annually while capturing and […]
Adaptive plots splitting Pfizer-partnered drug discovery unit from diagnostics business
Adaptive Biotechnologies is planning to separate its drug discovery and diagnostics businesses,
These 36 Scientists Are Leading the Way to Biomedical Discoveries
On June 16, Pew announced the 2026 class of Pew Scholars Program in the Biomedical Sciences, Pew Latin American Fellows Program in the Biomedical Sciences, and Pew-Stewart Scholars Program for Cancer Research. These researchers will receive multiyear grants and join a community of more than 1,000 scientists who are taking creative approaches to cancer biology, neuroscience, immunology, and more.
Science is under pressure again. Here’s what that means for young researchers
When Emma Scales decided she wanted to be a scientist, it seemed logical—simple, even. Now a Ph.D. candidate at Cornell University, Scales is studying symbiosis, specifically the way bacteria can gro...
Eric Topol
The famed cardiologist discusses how AI has transformed biomedical science
Sally Kornbluth
The university president and biomedical scientist talks about the hope and doubt in U.S. science today
Platner and Starmer remind us that character matters in politics
The UK premier has a litany of broken promises behind him, while the US Senate hopeful has shown dubious judgment
OPCW and UNODA partner to bridge gap between scientists and policymakers
Scientists learn how to apply policy and diplomacy at OPCW-UNODA workshop on chemical and biological disarmament
Fluorescent nanosensor enables rapid, first-of-its-kind detection of key gut health biomarker
Researchers developed an optical nanosensor to rapidly detect a key gut biomarker, enabling faster, accessible screening for conditions such as inflammatory bowel disease, Type 2 diabetes, and liver disease.
"Three Women and Me" Launches a Bold New Health Media Platform Designed to Change the Conversation Around Women's Health and the Issues Families Face Every Day
Award-Winning Producer Charles Mattocks and Bionic Bloom's own Dr Angela Fisher- Join Heather Reilly Hiemstra, Dr. Jenny Vaughn-Curtman, and Dr. Cathleen Gerenger, for a Powerful New Television Series and Podcast Featuring World-Renowned Experts, ...
Division of Biological Sciences announces five new faculty hires
The Division of Biological Sciences announced today that it has recruited five new faculty members. The incoming cohort represents the best and brightest from across the country, growing all three
Katie Thurston Delays Biopsy, New Treatment for Stage 4 Breast Cancer for 'Mental Health Reasons’: ‘I Need a Break’
Katie Thurston has been open about her fear of needles and the emotional toll of her stage 4 breast cancer journey. The ‘Bachelorette’ alum said she’s now pushing back a biopsy and new treatment to prioritize her mental health.
Janelia’s Two Big Bets: Decoding the Brain and Reinventing How Science is Done
HHMI’s Janelia Research Campus is launching a decade-long scientific effort to pursue two coequal goals: understanding how the brain generates complex behavior, and developing a new mode of scientific discovery in which biologists and AI work together as partners in discovery.
NASA Spaceline Current Awareness List #1,204 12 June 2026 (Space Life Science Research Results)
NASA Spaceline Current Awareness List
Jay Shetty Says His 'Body Couldn't Keep Up with His Vision' Before Prioritizing This One Aspect in His Wellness Routine (Exclusive)
The global bestselling author and podcast host, 38, talks to PEOPLE about his health journey and latest partnership with BIOptimizers.
Penn launches $18 million facility to advance RNA technology’s role in health, agriculture
The RNA manufacturing hub opened this spring in University City. The National Science Foundation has invested in five such facilities nationally, each focused on a specific biological material.
BioSTL Builds Gateway for U.K.'s National Health Service Innovators with St. Louis as Launch Point into U.S. Market
BioSTL Global, the international arm of BioSTL, the backbone of the region's bio-innovation ecosystem, has reached an agreement with the innovation network commissioned by the U.K.'s National Health Service (NHS) that promises to attract new companies to St. Louis' nationally recognized healthcare industry.
Rejuvenate Bio and Merck Animal Health Join Forces on Novel Animal Health Gene Therapy Programme
Rejuvenate Bio and Merck Animal Health Join Forces on Novel Animal Health Gene Therapy Programme
Commission to examine how precision approaches improve healthcare effectiveness, cost-efficiency, equity, and scalability worldwide.
Prof. Michèle Ramsay at the Sydney Brenner Institute for Molecular Bioscience is one of four co-chairs of the Lancet Commission on Precision Health.
These Portland trail guides build community through science, education and whimsy
“Drag Me Outside,” where field biology meets fabulousness.
ADHD is linked to chronic pain and other conditions. Here’s what we know.
Though it’s not yet clear whether the links are biological, research is beginning to uncover promising connections.
Scientists found a surprising problem with sugar-free diets
A surprising new study suggests that completely eliminating sugar may backfire. Mice on a sucrose-free low-fat diet showed worse blood sugar control, increased inflammation, disrupted gut bacteria, and signs of fatty liver compared with mice that consumed some sucrose. Researchers say the results highlight the importance of a balanced diet and a healthy gut microbiome rather than focusing solely on cutting out sugar.
A career of taking biological species for a spin
Nature Reviews Chemistry - Ahead of his 70th birthday, Adriaan (Ad) Bax, Distinguished Investigator at the National Institutes of Health (NIH), spoke about his career in science.
NMSU helps launch biotech game that lets students explore science careers
NMSU and UConn Extension developed a free 4-H biotech game that lets students explore 10 science careers through hands-on tasks.
Months After the FBI Raided His Garage Chemistry Lab, Teen Science Prodigy Graduates from College (Exclusive)
"It was all an unfortunate misunderstanding," says 18-year-old Amalvin Fritz, who is applying to medical school and launching a biological science startup
Second Vanderbilt Health team wins NIH Replication Prize
Led by Simon Vandekar, PhD, a group of biostatisticians earned the honor for tools that help brain researchers tell strong, trustworthy findings from weak ones. Vanderbilt took two of 15 total NIH prizes.
Photo of the Week: Leap of Science | Notre Dame Magazine
Gracie Hedgpeth, a biological sciences doctoral student, holds a bullfrog, steaming on a hot and humid evening, at the ND-LEEF research facility at St. Patrick's County Park in South Bend. Look for more in our summer issue, in the mail and online in early July,…
How fast can you grow a forest in a parking lot?
Plan a miniforest to restore biodiversity in unexpected places.
UFC announces global sports diplomacy partnership with U.S. State Department
In a development that has forever merged the worlds of combat sports and international affairs, UFC CEO Dana White and U.S. Secretary of State Marco Rubio signed a landmark Memorandum of Understanding at the State Department headquarters. Dana White doesn't approve of steady growth and instead ...
Texas Tech University Health Sciences Center Appoints New Graduate School of Biomedical Sciences Dean and Vice Dean
TTUHSC has named Lance R. McMahon, Ph.D., as the new Graduate School of Biomedical Sciences dean and Kendra P. Rumbaugh, Ph.D., as vice dean.
Texas Tech University Health Sciences Center Appoints New Graduate School of Biomedical Sciences Dean and Vice Dean
TTUHSC has named Lance R. McMahon, Ph.D., as the new Graduate School of Biomedical Sciences dean and Kendra P. Rumbaugh, Ph.D., as vice dean.
Rubio compares the founding of the UFC to landing a man on the moon
US Secretary of State Marco Rubio extolled the virtues of the Ultimate Fighting Championship as being intrinsically American, likening its creation to putting the first man on the moon.
Microbiology DNA and Chemistry for Health Insights Tops Research Schedule
Microbiology dominated the research schedule aboard the International Space Station on Thursday helping doctors protect health on Earth and in space. The Expedition 74 crew also tested a new spacesuit, packed a U.S. cargo spacecraft, and kept up lab maintenance throughout the orbital outpost.
Engineering’s Shuo Li selected for Crain’s Cleveland Business’ 2026 Notable Leaders in Architecture, Engineering and Construction | CWRU Newsroom
Shuo Li, PhD, the Leonard Case, Jr. Professorship in Engineering at the Case Western Reserve University Department of Biomedical Engineering, was sele...
Juliano Valdi takes us behind-the-scenes of Michael Jackson biopic (exclusive)
'Michael' star Juliano Krue Valdi is sharing happy memories from the set of the Michael Jackson biopic, including hilarious moments with costar Colman Domingo and winning $50 in a bet with director Antoine Fuqua.
7 Postbiotic Foods to Help With Gut Health
If you’re interested in a healthy gut, nutritionist Jo Woodhurst says postbiotics should be on your radar.
Using AI for medical advice; pelvic floor exercises; the hidden dangers of burning incense; plus other stories with Vanderbilt Health sources
Colin Walsh, MD,Associate Professor of Biomedical Informatics, was on WTVF News Channel 5‘s “Morningline” show in an interview about whether or not it is safe to use AI for medical advice. Time magazine reporter Stacey Colino interviewed Elisabeth Sebesta, MD, Assistant Professor of Urology, for a story about pelvic floor exercises for issues including menopause, erectile dysfunction and urinary incontinence in men. “Each Breath,” published by the American Lung Association, quoted Brian Christman, MD, Adjunct Professor of Medicine, for a story about the hidden dangers of burning incense. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Healthline (low vaccination rates lead to more cases of measles, whooping cough and other preventable diseases); ABC News (U.S. measles cases surpass 2,000 for second year in a row); and CIDRAP News (high-dose flu shots cut rates of hospitalization in older adults). Sarah Rohde, MD, Associate Professor of Otolaryngology-Head and Neck Surgery, was quoted in a People magazine story on patient Makalii Andrade, a surfer from Kauai Island who suffered a serious neck injury in 2022 and recently underwent surgery at Vanderbilt Health to begin the final phase of his recovery. James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a piece in Nature about antibodies against a strain of Ebola. SFGATE reporter Gillian Mohney interviewed Xue Zhong, PhD, Research Assistant Professor, Division of Genetic Medicine and Clinical Pharmacology, for a story about a study of a blood test looking at Alzheimer’s disease biomarkers. Matthew Franklin Mart, MD, Assistant Professor of Medicine, was quoted in a Healio story about how inflammation and illness severity is linked to less cognitive resilience after a person has been an ICU patient. The “How We Really Feel” podcast host Sula Windgassen, PhD, interviewed Lindsey C. McKernan, PhD, MPH, Associate Professor of Psychiatry & Behavioral Sciences, Physical Medicine & Rehabilitation and Urology, for an episode focusing on pelvic and bladder health. The podcast is also available on YouTube and the podcast website. In addition, podcaster Monica Sanford interviewed cardiologist Mark Glazer, MD, for her podcast “The Monica Sanford Show”; the two-part interview is here and here.
Cal Poly offers first synthetic cell course to students, partnering with network of innovative scientists
A new course offered this spring quarter at Cal Poly introduced upper-division undergraduates to the fundamentals of building synthetic cells while collaborating on innovative projects. The cutting-edge course titled “Engineering Synthetic Cells,” taught by Javin Oza, a Cal Poly biochemistry associate professor, involves a partnership with the San Francisco-based company b.next, an open-source synthetic cell platform Nucleus, and an international science network.
Heart Health Biotech Kardigan Seeks $373.3 Million in US IPO
Kardigan Inc. is seeking to raise $373.3 million in a US initial public offering to help fund three late-stage drugs that target cardiovascular diseases.
This evolutionary biologist fuses art into her science
Victoria Glynn is studying how high temperatures are affecting ocean plankton. She also makes art to help communicate science to the public.
A Newer Approach to Editing Embryos Ignites Debate
Fertility specialists, biotech companies and ethicists are divided over whether progress in early gene editing would wipe out diseases or trigger a rush toward enhancement.
Scientists discover a hidden cause of aging cells that can be reversed
Researchers discovered that declining levels of phosphatidylcholine may be a major cause of age-related mitochondrial dysfunction and loss of cellular energy. Remarkably, boosting this nutrient restored more youthful mitochondrial performance in aging organisms, suggesting some aspects of aging can be slowed or reversed.
Browns QB Deshaun Watson says this is the first time he's been fully healthy since 2023 Week 3 vs. Titans
The largest scorpion to walk the Earth was the size of a baseball bat
Scientists describe a baseball bat-size scorpion — the world’s largest — and suggest that the 400 million-year-old creature was also amphibious.
In a first, scientists translated an entire viral genome so a quantum computer could read and analyze it
Scientists have uploaded a viral genome to a quantum computer, marking an important step for the future of quantum-enabled advancements in biology.
How science is securing Michigan's pork future
Seventy-five percent of state's pigs are now covered by an SPS on-farm biosecurity plan, strengthening the responses farmers will have to an FAD.
Archetype Entertainment founder and BioWare veteran wishes Exodus didn't look so much like Mass Effect
But he thinks the team is doing a "good job" moving it further away from BioWare's sci-fi romp.
Biochemistry Student to Participate in National Science Foundation Undergraduate Research Program
Elmhurst University biochemistry major Hannah Cardenas ’27, of Des Plaines, Illinois, received a National Science Foundation Research Experiences for Undergraduates (NSF REU) award to participate in a 10-week summer research internship at the University of Texas at Dallas.
Biobehavioral health researcher earns Lloyd Prize for Innovative Health Research
Penn State’s Social Science Research Institute has announced Mohanraj Krishnan as the recipient of the 2026 Lloyd Prize for Innovative Health Research made possible by an endowment created by Penn State Professor Emeritus Thomas Lloyd, who served on the College of Medicine faculty for 46 years.
Texas A&M advocates nutrition education for tomorrow’s nurses
The Nutrition-to-Nursing pathway provides a deeper understanding of the biological systems that underpin health and disease.
The Franklin Institute and GSK celebrate 40 years of GSK Science in the Summer™ with a new "Be a Chemist!" theme and program expansion
A free hands-on STEM enrichment program led by The Franklin Institute and supported by GSK, celebrates its 40th anniversary in 2026.
Earth's first animals barely evolved until sex changed everything
Earth’s earliest animals may have held evolution back because they reproduced asexually, creating low-competition communities that changed very little over time. When environmental pressures pushed them toward sexual reproduction, biodiversity exploded and evolution accelerated dramatically.
Popular joint supplement glucosamine linked to faster Alzheimer’s progression
A major study suggests glucosamine, a popular supplement for joint pain, could be linked to faster progression from mild cognitive impairment to Alzheimer’s disease. Researchers found a 25% higher likelihood of developing dementia among glucosamine users and uncovered biological clues that may explain why.
How sky-high ticket prices, war & politics could impact the World Cup
The biggest World Cup ever starts this week. Laura Williamson, editor in chief of The Athletic, describes how sky-high prices, travel restrictions, politics and the Ebola outbreak are impacting fans. Williamson also discusses President Trump’s UFC event on the White House lawn. Ken Tucker reviews Kacey Musgraves’ album ‘Middle of Nowhere,’ which he says pairs well with the music biography ‘Gary Stewart: I Am From the Honky-Tonks.’
President’s message: Progress and opportunity for science and medicine
his is an extraordinary moment in time for the biomedical sciences. Seven decades ago, the discovery of the structure of DNA sparked a revolution in understanding life. In the decades since, the knowledge of fundamental biology we have accumulated has led to innovative treatments for many difficult-to-treat diseases, and many more are now within reach....
Sex jumpstarted Earth’s animal biodiversity
Many species didn’t have much sex for millions of years. They didn’t need it.
Hubble Science in the 2030s White Paper: High-Contrast Optical and UV Spectroscopy with HST/STIS
The Space Telescope Imaging Spectrograph (STIS) on the Hubble Space Telescope currently stands as the sole space-based astronomical facility providing visible-light coronagraphic imaging — and the only facility anywhere that can perform both visible- and ultraviolet-light coronagraphic spectroscopy. In imaging, STIS offers unparalleled stability that rivals the performance of ground-based direct imaging in the optical, […]
The Code As Witness: A Book About Science, Politics & Pandemic Inquiry
The Code as Witness written by Steven C. Quay is part scientific investigation, part policy strategy, and part warning about the future of biological research.
The Code As Witness: A Book About Science, Politics & Pandemic Inquiry
The Code as Witness written by Steven C. Quay is part scientific investigation, part policy strategy, and part warning about the future of biological research.
Scientists Unethically Experiment On the Unborn to Improve Gene Editing Techniques, Bioethicist Says
Genetic researchers are experimenting on unborn children in trials that could have been done on animal embryos, according to one bioethicist.
23 student researchers receive 2026 NSF fellowships - College of Arts and Sciences
The National Science Foundation awarded work in STEM-related fields such as artificial intelligence, biomedical engineering and marine ecology.
GREX-PLUS Science Book v2
GREX-PLUS (Galaxy Reionization EXplorer and PLanetary Universe Spectrometer) is a mission candidate for a JAXA strategic L-class mission to be launched in the 2030s
Your DNA is changing all the time. Here’s why
We tend to think of the DNA strands that contain our genetic code as consistent, stable units. But in reality, the cells that make up our bodies are constantly replicating and changing. Even as you read this sentence, in fact, the genes within your cells are mutating. So, what causes these mutations and what’s the impact? Science writer Roxanne Khamsi examines the answers in her new book, Beyond Inheritance. Today on the show, she gets into how scientists examine these mutations, how they’ve shifted our understanding of disease and what the future of genetic therapy could entail.Interested in more biological and life sciences? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.
BEACON: How Benchmarking Combats the Reproducibility Crisis in Modern Science
A new initiative called BEACON aims to advance scientific reproducibility by uniting siloed benchmarking efforts across biomedical research.
NASA Spaceline Current Awareness List #1,203 5 June 2026 (Space Life Science Research Results)
NASA Spaceline Current Awareness List
Planetary Science Analysis and Assessment Group Support
Earlier this year it was announced that NASA’s Planetary Science Division to cease financial support for planetary science Analysis/Assessment Groups (AGs), effective the end of April 2026.
Lyme Primer: How the New HHS Strategy Stacks Up To Science
Experts support targeting ticks but caution against the long-term use of antibiotics.
We can create the future of science right now
Paul Litvak is the founder and Executive Director of the Robyn Dawes Institute and a Visiting Scholar at UC Berkeley. He has a PhD in Behavioral Decision Research from Carnegie Mellon where he studied emotions and the sunk cost bias. Over 15 years in industry, he solved a wide range of challenging technical problems. At Meta he created models optimizing the ad review process. At Google he ran experiments to measure social influence. At Airbnb, he was a product manager leading machine learning teams optimizing search ranking and price suggestions. He also co-founded and led product at Rhythmic Health, a venture-backed biosensing startup, creating an accurate low cost system using a color changing strip and a smart phone to measure salivary lactate. The bottleneck At this point, it is uncontroversial to say that science needs to stop using the PDF article as the unit of knowledge and currency. The unbearable slowness of scientific publishing, the profit motive and margins: I’m not saying anything new. The PDF also sucks because it’s hard to extract structured information, which makes it hard to do evidence synthesis. As a result, we do much less evidence synthesis than is needed. And evidence synthesis ultimately undergirds most policy and medical decision-making. I can see second-by-second real-time odds for any sporting or newsworthy event, but a school board can’t see the best evidence on whether their 8th graders should be taught algebra. As a society, we don’t treat this as an important problem. Again, not controversial. Not only is the problem well understood, but the solution has already been laid out. What we need is AI-assisted living evidence synthesis - (1) an open knowledge graph of atomic claims, (2) claims linked to evidence, (3) assessment and synthesis of each piece of evidence, and (4) continuous updating with new data. What few realize (yet) is that the technical capacity to build this vision for a significant portion of science already exists. Not only that, scientists and startup teams are already building many of these components. I know this because I’ve been surveying the space and talking to many of the builders. There are some missing pieces: for example, evaluations of how well some of the components work. But at this point, most of what’s missing is a fully end-to-end working integration of all of these parts. In the rest of this essay, I’m going to lay out all the parts of a working living evidence layer for science and who is working on them, and propose concrete next steps for building this system. What’s now possible The diagram above outlines the components of a living evidence synthesis platform, including some of the teams working on each component1. Scientific PDFs are processed into claims with associated evidence. The evidence is subjected to a forensic audit, methodological evaluation and robustness and reproducibility checks. Finally it’s given a weight in a continuously updating synthesis. What follows is a description and status of each component and a few of the teams working on them. Document understanding The first thing you need to be able to do is turn an article into structured data. Mostly that means parsing PDFs. There are often multicolumn layouts that confuse non-specialized PDF to text processing libraries. For scientific papers, there is the added complexity of parsing formulas and tables and figures. This is a really hot area - there are startups offering APIs, and it seems like a new open source package gets posted to Github every few weeks. What follows isn’t exhaustive. A package called GROBID was the state of the art for a while, they didn’t update their package for nearly two years until very recently. In the meantime reducto.ai released an AI powered PDF extraction API, PaddleOCR became popular, IBM released a model called Docling, and both Mistral and Gemini created models and libraries. I also know of at least one other well-funded psychology research group working on a paper parser. By contrast, there are few open evals in this space, with no extensive evals for complex table comprehension in particular. Nonetheless, I’m confident this will be a solved problem soon, given the combination of LLM advances and developer interest. Hypothesis level extraction There has been increasing interest in comprehending the extracted text of papers and linking information to evidence for each hypothesis. A lot of work has already been done. Trialstreamer (Marshall et al. 2020) and RobotReviewer LIVE (Marshall et al. 2023) demonstrated automated extraction of trial population, intervention, and outcome at scale on clinical RCTs. PaperQA2 (Skarlinski et al. 2024) and Ai2 ScholarQA (2024) extended this to retrieval-augmented question answering with citation grounding. Elicit, Consensus, and SciSpace operationalized claim-level extraction for end users. OpenEval (Booeshaghi et al. 2026) is the most recent and most ambitious: 1.96 million atomic claims extracted from 16,087 eLife manuscripts using Claude Sonnet 4.5, grouped into ~299,000 results, with LLM evaluations showing 81% agreement with human peer review on a 2,487-paper subset. None of these solutions link claims to test-statistics, as you would need to evaluate randomized controlled trials. This is why I built the evidence.guide API - to extract hypotheses and associated test statistics from behavioral science papers. The best public eval of this kind of extraction I’m aware of comes from the recent SCORE project - they had humans code thousands of psychology papers to extract their claims by hand. It would be extremely helpful to the world if all scientific PDFs were available as structured open data. I’ve been working to make this happen, both directly at Berkeley and through coordination with large entities I can’t yet speak of; as hard as it is to do, I think it’s possible2. Forensic audit A lot of work has been done on forensic audit, but some gaps remain. Of course, for biology papers that rely on images for evidence, there are a variety of tools (notably Proofig and ImageTwin) to spot anomalies. These are still well short of what sleuths like Elizabeth Bik can do on her own, but these tools are constant companions among fraud analysts. There’s someone working on auditing Excel files for anomalies, and a number of teams are automating numerical checks like GRIM and SPRITE, including Scrutiny project, the INSPECT-SR team as well as statcheck. The regcheck team is building a way to use AI to compare preregistrations to analyses in papers, to ensure there aren’t significant deviations. Nonetheless, there are many other kinds of anomalies to screen for, both public and less publicly known. And there are no formal evals for anomaly detection that I’m aware of. Still, there’s a lot to draw from in this space and I’m pretty certain we will be able to scan papers for most kinds of obvious anomalies in the near future. Methodological review This area has been white hot, though I fear for many of the startups in this space, because this capability may become commoditized. There are at least six different AI peer review companies, including Refine.ink, Reviewer3, ReviewerZero.ai, Q.E.D. Science, Paper Wizard, and Isitcredible. Coarse (a pun on refine) was also recently created as an open source alternative. These systems provide qualitative feedback on the content of papers, spotting methodological weaknesses and mathematical errors. They seem to work pretty well, and many academics report bitterly that they exceed the average quality of typical peer reviewers. But there are few evals here either. What evals exist so far involve using LLM-as-judge (circularity problems abound) or comparing against human reviews of questionable quality. What you’d ideally want is an eval that measures capturing known errors in papers3. Reproducibility and robustness Another active area has been using AI agents to automate computational reproducibility4 and robustness5 checks in papers that report numerical results. For more recent papers where data and code are available, AI agents can see whether they can re-run the analyses and produce the numbers reported in the published paper. In addition to a handful of individual academics who have been experimenting using Claude Code for this, the Institute for Replication is a leading group working on building an end to end system. The evals related to this problem are the most mature, with CORE-Bench (Siegel, Kapoor, Narayanan 2024) and PaperBench (OpenAI 2025) available to benchmark agents on this task. There is also work on getting AI agents to test alternative ways of analyzing the data to ensure the results are robust to small analytic design choices. Synthesis This is the most underdeveloped area where significant investment is required. Although some automated evidence synthesis systems exist — for example, otto-sr is building an AI agent to write systematic reviews — none of these incorporate the full range of paper level signals to weight evidence appropriately. Nor is there anything like an eval or a gold standard for a good systematic review. Arguably Cochrane reviews are the closest we have to gold standard human systematic reviews, though I’ve heard academics in the know complain about their uneven quality. A key question for a synthesis platform is how to weight anomalies and methodological issues in assessing the quality of a piece of evidence. This is an unsolved problem and one I’m very keen to work on. Continuous updating There are many pieces of basic infrastructure available for monitoring for new research and initiating updates. OpenAlex is the current open citation graph. Retraction Watch integrated into Crossref in October 2023. Scite tracks how citations support, contrast, or mention prior claims. The Living Evidence Network demonstrated continuous-update workflows in clinical guidelines. Engineering this is a relatively straightforward task. When you look over this technical architecture and all the progress being made, it’s hard not to be optimistic that a living guide to scientific evidence will be built. The stakeholders are ready The social infrastructure for this is starting to coalesce — it’s not just a pie in the sky academic exercise to imagine this coming into existence. Institutions like the Center for Open Science, the Institute for Replication, the INSPECT-SR, the Living Evidence Network and more are all working on scaling work to improve research quality. Funders are also aligned. The Sloan Foundation has funded living evidence work through COS. Coefficient Giving supports the Institute for Replication and COS. The Astera Institute and the Institute for Progress have shown interest in this space. NIH has established an Office for Replication and Reproducibility. Although there are (very unfortunately) serious headwinds in science funding generally, there is an active group of funders interested in metascience. A brief word about what I’ve been doing at RDI. First, as a Visiting Scholar at Berkeley I’ve been actively figuring out how a non-profit and a public university can conduct and make public the results of large-scale academic article data mining. With some of the money I raised from donors, I commissioned a legal analysis of recent case law and publisher text data mining (TDM) agreements in order to understand whether a massive open data mining of academic articles is possible (with caveats, it is). I’ve also been working to bring together stakeholders in this space, and identify gaps. I’ve also been doing some software development in this space, with more to come. A pilot proposal The assumption undergirding all of this is that an AI, given all this information, would make the right judgment about a scientific claim with lots of conflicting evidence, weighing all the factors appropriately. That’s the hypothesis we need to test. Randomized control trial research is the best place to focus on first. RCTs are used to make many of the important decisions in society - from medical trials to public policy changes. And they use a relatively uniform set of inferential statistics with lots of known and available diagnostics. Behavioral science experiments, within the broader realm of RCTs, should be first used as a testbed whose results can be generalized. Because behavioral science is at the vanguard of open science practices, replications abound (there are thousands of them) to serve as ground truth training data. Key Hypothesis Therefore the pilot would test, in behavioral RCTs that have been replicated, whether the quality of evidence for a claim can be used to accurately predict whether that claim will replicate. Secondary Hypotheses Compared to claims that replicated, non-replicated claims demonstrate a greater share of forensic anomalies in their source literatures. Hypothesis level claim and statistic extraction is accurate enough to scale living evidence without onerous human review costs. Replication prediction is more accurate than prediction markets6 or journal prestige. If all the different quality signals we gather do accurately predict which studies will replicate, then we can use that model to score evidence to power the living evidence layer. Why this is informative regardless of outcome If the pilot succeeds, the architecture extends to medical RCTs (where Living Evidence already operates and integration is mostly about claim representation), then to slices of basic biology with stable replication structure. If it fails, the field learns which quality signals are load-bearing and which ones metascience has oversold. Either result is a contribution to knowing what the literature supports. Implications for funders Because this burgeoning ecosystem of builders already exists, a well-informed philanthropic or government funder could play a crucial catalyzing role in bringing this future about. They could play at least three roles: creating open structured datasets, publishing open benchmarks and incentivizing the solving of key technical challenges. First, open archives of papers that the government maintains, like PubMed, could be turned into structured data amenable to large scale metascience and claim aggregation. I know the US government already has an interest in doing this, though some key open questions remain unanswered. How do you determine the best models and systems for accurately extracting information from papers? How can you establish a robust way to allow researchers to flag errors and correct them? And finally, how do you create a legal regime in working with publishers to maximize the scope of available papers? For the latter, a university or a private philanthropy may be better positioned to make structured data publicly available under journal subscription terms or fair use. Philanthropists or government funders could also coordinate to create or commission benchmarks that evaluate whether important problems have been solved. For example, an open benchmark for claim extraction from a range of different scientific article types would be extremely helpful. Ensuring the underlying data are accurate is vital for creating these evaluations. I’ve discussed opportunistically using various human-created datasets for this purpose, but a consistent problem is that errors in human data make it difficult for them to serve as a gold standard. Finally, with structured data and benchmarks available, the government or private philanthropy could use them to incentivize groups to develop machine learning systems that meet these benchmarks. Prizes are one potentially valuable tool for this. For example, you could establish a prize for a system that accurately updates a living meta-analysis for a small set of claims. Prizes are particularly useful as signals of problem importance, and can help create vibrant ecosystems of public and private research—see, for example the role the government played in kickstarting the current work on nuclear fusion. Conclusion The drawbacks of the current scientific publishing system are known. Scientists agree, metascientists agree, philanthropists agree: the published PDF plus citation graph isn’t the right substrate for maintaining a representation of the evidence base in science. The pieces needed to build the alternative either already exist or are rapidly taking shape. The community is forming around exactly this problem, with concrete partnerships and shared infrastructure. A pilot should start on behavioral science RCTs because that’s the slice of empirical science most amenable to legibility, where replication ground truth is richest, and where the failure modes are best documented. What’s been missing is the galvanizing mission to assemble these pieces into something that works. That’s what I’m proposing to build. *** 1 I have a broader field map that I’ll release publicly soon. This is me, building in public! 2 If this is something that you are excited about, please reach out and talk to me. 3 More on this very soon too! 4 This tests whether, given the code and the data, you can get the same statistics as reported in the published paper. 5 This tests whether the results are the same as a paper’s given alternative analytical decisions in conducting the analysis (like outlier omission). Closely related is the idea of a “multiverse” where you come up with many different ways of answering the same underlying research question with the same data, and test whether the results hold in all those alternative methods. There’s been work on the latter as well. 6 Some of the replications, e.g. those from the SCORE project, had paired the experiments with forecasts from prediction markets. So we get to look at this for free.
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