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Barcelona label double Ballon d’Or snub ‘a worldwide scandal’
Barcelona sporting director Deco has this week made public the collective disbelief at the club regarding the exclusion of Blaugrana pair Raphinha and Pedri from the Ballon d’Or shortlist.The subjec...
Malik Nabers fully practices Thursday
Giants WR Malik Nabers listed as a full participant for second straight practice
Can a Live Nation-backed Atlanta label be a musician’s ‘reset?’ This exec thinks so.
Music executive Kei Henderson, who formerly served as 21 Savage's manager, started Third & Hayden to help boost musical artists' careers while maintaining their mental health.
Grammy-winning country singer admits to being drunk during concert, didn’t want to cancel
The 36-year-old Grammy-winning artist made the confession during a recent appearance on Entertainment Tonight’s “Sip or Spill” game.
College Football Over/Under Picks for Week 2
Get Chris Vasile’s college football Week 2 Over/Under picks and predictions for Oklahoma vs Michigan, Arizona vs BYU, and Arkansas vs Utah.
Israeli legislative election and Netanyahu's politics of enmity
Rather than labeling his domestic rivals as outright traitors, Netanyahu frames them as the vehicles that will deliver the enemy's desired outcome. This deliberately blurs the line between legitimate political dissent and national betrayal | Anadolu
See it: Giants' Malik Nabers headbutts Cam Skattebo mid-interview
New York Giants WR Malik Nabers hilariously headbutted RB Cam Skattebo during a live interview.
Packers TE Tucker Kraft Makes Bold Request With Contract 'Standoff'
As Green Bay nears its season opener, a $20 million demand from the rising tight end threatens to reset the market and force a high-stakes financial crossroads.
CenTrio Selected as a Houston Business Journal Best Place to Work
CenTrio, a leading district energy provider headquartered in Houston, has been named a Best Place to Work by the Houston Business Journal. CenTrio provides heating, cooling, and power solutions in downtown cities and campuses across the United States.
Hearts 'have to be above emotions' as big favourites
Hearts head coach Wouter Vrancken insists there can be no excuses as his side prepare to face Stenhousemuir at Ochilview on Friday with a place in the Premier Sports Cup semi-finals at stake.
Henrico Business Watch: Business license filings Aug. 31-Sept. 6, 2026
Aug. 31-Sept. 6, 2026 Henrico County reported 40 business-license filings with start dates during the week. The filings are listed alphabetically by business or trade name, followed by a registered address and business industry classification. 9317 Property, LLC, 9317 Becton Road, Glen Allen – Manufacturing, Non-profit and Other.
Fit after 14 months out - Weiser an option for Bremen
Bremen (dpa) - Werder Bremen's Mitchell Weiser is closing in on his comeback, 14 months after a serious knee injury. The 32-year-old full back could return to Bremen's matchday squad on Saturday away to his youth side Cologne.
Broncos' projected depth chart with practice squad players included
Here's our projected depth chart for the Broncos, with practice squad players included.
2026 Heisman Week One Poll
Welcome to the 2026 Heisman Week One poll. We had a very full and long weekend of football games. There has been some movement in our weekly Heisman Poll. Arch Manning and CJ Carr both dropped out of the poll. They both received minimal votes and were barely a blip on our radar. Miami made …
Rangers Going For Series Win Over Rival Mariners
The Texas Rangers have a chance to shake off some of their road struggles as they go for a series win over the Seattle Mariners.
Scientists want to 3D print houses on Mars with the help of yeast
Mars is a terrible place to build a house. It’s bitterly cold, blasted by radiation, and a near vacuum. Not to mention that the building materials, even for a modest shelter, could spend months hurtling through space before construction begins. But they don’t have to. In a study publishing September 10 in the journal Chem Circularity, researchers developed a recipe that could one day be used to 3D print houses on Mars. The recipe combines Martian rocks with Earthly ingredients: gelatin and yeast. Once dried and hardened, this living building material is as strong as low-grade concrete and can be broken down, recycled, and brewed again for new construction.
Matt LaFleur makes Jordan Love’s elite status crystal clear
The Green Bay Packers are set to begin the 2026 campaign in just a few days, with the team looking to put two consecutive Wild Card round losses behind them. Last season ended particularly painfully, as Green Bay blew a sizable lead against the Chicago Bears on the road and suffered another early playoff exit. [...]
Match Gallery: St Johnstone v Celtic
Celtic continued their 100 per cent start to the defence of their title with a 1-0 win over St Johnstone at McDiarmid Park last night (Wednesday).Mika Baur netted the all-important goal seven minutes ...
Oswego Players announce 2026 Don McCann contest winners
OSWEGO — “Undiscovered Country” has taken top honors in the Oswego Players 2026 Don J. McCann Memorial One-Act Play Writing Contest.By Dana Leslie Goldstein of Brooklyn, “Undiscovered Country” examines losing a loved one and how, through memories, lost love can be found. A panel of 15 volunteer judges praised it for its flow of dialog and richly developed characters. Goldstein receives a $250 cash prize. × This page requires Javascript. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. kAmv2C?6C:?8 2 S`d_ D64@?5\A=246 AC:K6 :D q6? sH@C t?@F89]” xE’D 2 DE@CJ @7 2 J@F?8 2FE:DE:4 >2? H9@ DECF88=6D E@ 4@?BF6C 9:D :??6C :?D64FC:E:6D 367@C6 2 3:8 2F5:E:@?]k^Am#placement_726068_0_i{width:100%;margin:0 auto;}var rnd = window.rnd || Math.floor(Math.random()*10e6);var pid726068 = window.pid726068 || rnd;var plc726068 = window.plc726068 || 0;var abkw = window.abkw || '';var absrc = 'https://ads.empowerlocal.co/adserve/;ID=181918;size=0x0;setID=726068;type=js;sw='+screen.width+';sh='+screen.height+';spr='+window.devicePixelRatio+';kw='+abkw+';pid='+pid726068+';place='+(plc726068++)+';rnd='+rnd+';click=CLICK_MACRO_PLACEHOLDER';var _absrc = absrc.split("type=js"); absrc = _absrc[0] + 'type=js;referrer=' + encodeURIComponent(document.location.href) + _absrc[1];document.write('');kAm%96 Sfd E9:C5\A=246 AC:K6 :D 2H2C565 E@ “p== 7@C 2 qF4
Longtime UNC Charlotte athletics administrator dies after battle with cancer
Longtime Charlotte Athletics administrator Tom Whitestone passed away Tuesday after a battle with cancer, the university announced Wednesday.
Which Texas college football stadium is toughest on visiting teams?
From deafening crowds to intimidating traditions, tell us which Texas stadium creates the toughest environment for visiting teams.
Josh Shapiro and Utah Gov. Cox condemn political violence in joint appearance on eve of anniversary of Charlie Kirk’s killing
Gov. Josh Shapiro said his family has repeatedly faced terroristic threats. "And oftentimes it’s rooted in an attack on me because of how I worship,” the governor noted.
Fenerbahçe vs AS Roma – Match preview and team news
AS Roma and Fenerbahçe return to the UEFA Champions League after a long wait and will now face each other in their opening UCL fixture this season on Thursday at the Chobani Stadyumu in Istanbul.Fene...
Letters: Is there such a thing as too much sports news?
I just finished reading the digital edition, Sept. 3, and as always, my thoughts on this newspaper are that it is nothing but a sports tabloid. I find a shortcoming
Patriots news: Mike Vrabel sums up doomed Drake Maye-led drive vs. Seahawks
The New England Patriots had a chance to avenge their Super Bowl loss in Week 1 against the Seattle Seahawks. They were driving down the field while trailing by three. With seconds remaining in the game, Drake Maye attempted to throw a touchdown. That is when disaster struck. Maye’s pass was intercepted by Josh Jobe in the end zone. The Seahawks […] The post Patriots news: Mike Vrabel sums up doomed Drake Maye-led drive vs. Seahawks appeared first on ClutchPoints.
Dianna Russini Career News Emerges Hours Before Patriots-Seahawks Game
Where is Dianna Russini now? Find out the latest news and rumors on Russini's next move amid the Mike Vrabel fallout. The post Dianna Russini Career News Emerges Hours Before Patriots-Seahawks Game appeared first on HEAVY.
Ralph Lauren delivers modern take on romance with sensual silhouettes
Ralph Lauren's New York Fashion Week show featured a starry guestlist with actors from Meghann Fahy, Cynthia Erivo, Viola Davis and Elizabeth Debicki in attendance. The designer's Spring 2027 show
Oregon Already Getting Disrespected by ESPN After Week 1 Win
Oregon had a very strange opening game on Saturday against Boise State. I think some are forgetting that Boise State is one of the better teams in the country, and while Oregon could have and should have played better, there's a very good scenario in which Boise State is a playoff team. We have to remember that at the end of the day, especially with Oregon still winning this game, the defense stepped up when needed.
Alaska continues rollout of Rural Health Transformation Program awards
Alaska Department of Health officials announced a fifth round of federal Rural Health Transformation Program funding awards on Friday. The latest awards for $25.8 million bring the total to more than $207 million to date.
Apple Reveals iPhone 18 Pro and iPhone 18 Pro Max Battery Capacities
Apple has confirmed the battery capacities for the iPhone 18 Pro and iPhone 18 Pro Max models that the company announced earlier today. Apple is required to publish energy labels on its iPhone product pages in the EU, and they reveal the official mAh battery capacities for the devices. Here are the battery capacities for the iPhone 18 Pro and iPhone 18 Pro Max models that still have a SIM card tray, according to Apple: iPhone 18 Pro: 4,056 mAh (+1.7% vs.
UF Health Jacksonville mobile health unit targets barriers to healthcare
UF Health Jacksonville expects its mobile health unit will provide blood pressure, cholesterol and diabetes screenings and preventative services.
Cabell-Huntington Health Department to Host Drive-Through Flu Vaccine Clinic Friday, October 2 - Cabell-Huntington Health Department
Huntington, WV – The Cabell-Huntington Health Department (CHHD) will host a drive-through flu vaccine clinic on Friday, October 2, from 8:30 AM to 3:00 PM. The clinic will take place […]
NASA’s Chandra Unveils Mysterious X-Ray Objects
Using NASA’s Chandra X-ray Observatory, scientists have discovered a new class of objects behaving unlike any they have seen before. Astronomers suggest these
Small Steps, Big Results - Butte Woman Finds Success Through Intermountain Health Healthy Lifestyles Program
For Leslie Lance, staying healthy has never been about dramatic changes. Instead, the 71-year-old Butte resident believes in taking one step at a time. Those small steps are paying off. After learning she was prediabetic, Lance enrolled in the Intermountain Health St. James Hospital Healthy Lifestyles class, a Diabetes Prevention Program. Af...
How serious is Corbin Carroll’s back injury after concerning update?
KANSAS CITY – Surviving the final weeks of the season without Corbin Carroll could be a recipe for disaster for the Arizona Diamondbacks. Only time will tell how serious Carroll’s back injury is, but the recent update isn’t a good one.
T-Pain sues Akon’s record label, claiming he’s owed nearly $500K in royalties
The singer alleges Konvict Entertainment failed to pay his full share of royalties from recent music sales.
Thunder Road, Lit Entertainment Launch New Banner
Basil Iwanyk and Erica Lee's film label and Adam Kolbrenner's management-production firm are teaming to create a new banner, TR/AK.
Boo! at the Ballpark returning to Gwinnett Field
Boo! at the Ballpark is coming back to Gwinnett Field in late October as the Gwinnett Stripers are again partnering with Dippin’ Dots to host the community Halloween event.
Ben Roethlisberger raises concern over Steelers thin running back room
Former Steelers QB Ben Roethlisberger questioned team's roster construction, warning that depth behind the primary running backs is dangerously thin.
Former Sunnyvale resident pleads guilty to health care fraud
Authorities say Sevindik Huseynov aided and abetted as scheme to submit thousands of bogus claims to Medicare Advantage programs.
Giants-Cowboys, Week 1: 5 storylines to watch
Malik Nabers’ status is the biggest story, but hardly the only one.
Kansas City Royals news: Witt’s future looks Golden
What will end first; the Kansas City Royals’ season or the heatwave the Midwest is suffering through?
Seminoles Surrender Back Breaking Play in 4th Quarter
FSU suffered a blow in the fourth quarter when SMU wideout Yannick Smith caught a 79 yard touchdown. Even though FSU responded, it was the biggest explosive play of the game, and the one that sticks out the most when you consider SMU had three plays of 50 yards or more, and eight plays of +15 yards.
Patriots 2026 season preview: Can Drake Maye defy expectations again?
Mike Vrabel soared in his Patriots coaching debut. How can he follow it?
Stark contrast with McLeish shows Robinson's Dons identity crisis
On Saturday, before his team's top-of-the-table clash with Celtic, I asked St Mirren manager Craig McLeish how easy it has been to implement the style of football that is enthralling the Paisley club's supporters amid their then unbeaten start to the league season. The man who led the Saints youth team under Aberdeen boss Stephen Robinson has produced a side that plays an exciting, fast-paced brand of football with a clear identity already. Eight new signings started the narrow defeat to the champions as well as Fraser Taylor, who was on loan at Partick Thistle last season.
Official | Auxerre loan Francisco Sierralta to Gliwice
Bought for just under €2m last summer, Francisco Sierralta (29) has joined Polish club Gliwice on a season-long loan. The deal, concluded on Wednesday, ahead of the closure of the transfer window in...
Survey: Will the Lions beat the Saints in Week 1?
Checking in with Detroit Lions fans in our latest SB Nation Reacts surveys.
Wall Street Loves CVS Health Stock Right Now. Should You?
The stock is down about 13% from its 52-week high.
The Market Forces Quietly Adding Thousands To Patient Bills
By Elisabeth Rosenthal and KFF Health News HealthDay ReportersWEDNESDAY, Sept. 9, 2026 (HealthDay News) — After a failed round of in vitro fertilization this year, Anne Hug’s fertility doctor said she had a single polyp in her uterus that should be removed to improve the chance of pregnancy. Hug, a ...
Is Elizabeth Holmes posting her way into a pardon?
I read all of Elizabeth Holmes' 6,000 prison tweets. Here's what I learned.
Baton Rouge General's Health Tip of the Week: Another sugar substitute raises heart concerns
Sponsored by Baton Rouge General Cutting back on sugar? Take a peek at the ingredient label before reaching for a sugar-free treat. Recent research has raised questions about xylitol, a sugar alcohol found in products like gum, candy and baked goods. Higher blood levels of xylitol were linked to a greater risk of heart attack […]
Qunabox Group Opens '99 Quna Festival,' Debuting Consumer-Facing Physical AI Entertainment
Hong Kong-listed Qunabox Group Limited (0917.HK) opened its "99 Quna Festival" here on Sept. 9, putting its consumer-facing physical AI entertainment business in the spotlight for the first time.
Dan Lanning's Ducks still not ready for college football's primetime
Oregon struggled to find consistency against Boise State to open the season.
US Open results 2026: Quarterfinal scores and semifinal bracket updates
US Open results and bracket updates for the 2026 men’s and women’s draws.
Let’s Grade That Win Over Coastal Carolina by Position Group
Hope everybody enjoyed the holiday the right way. Grill going, family around, maybe a cold drink in your hand, and a win in the books to talk about while you do it. That’s the good life. Before we get too deep into the cookout, let’s talk about what we saw Saturday, because there’s a lot […]
Tribal consortium achieves long-desired ownership of Alaska Native Medical Center
The nation’s biggest tribal health organization now owns the Anchorage hospital it has long operated.
Samsung Health Recognized for Connected Care Innovation With Medicare App Library Inclusion and Recognition of Excellence for Its Support of “Kill the Clipboard”
Samsung Health has been added to the Medicare App Library. The inclusion follows Samsung’s recognition from CMS for its "Kill the Clipboard" initiative, advancing its vision for connected care.
Is Davion Mitchell the Miami Heat's Biggest X-Factor?
Gabe Vincent highlights Davion Mitchell’s offensive impact, but Pelle Larsson could prove even more vital to the Miami Heat's championship aspirations.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Endometriosis may increase type 2 diabetes risk
Researchers found that some women with endometriosis may have increased risk of developing type 2 diabetes.
Raiders fans were not in favor of signing Von Miller
Las Vegas fans don’t feel like they need veteran pass-rusher
SKY BLUE CINEMATIX - ENTERTAINMENT - BRAND INTEGRATION : Two Films. One Global Partnership.
Sky Blue Cinematix appointed exclusive worldwide brand-integration partner for two new features from Tested Films.London, UK, Sept. 08, 2026 (GLOBE NEWSWIRE) -- Sky Blue Cinematix, the entertainment and brand-integration division of Sky Blue Media Group, today announced its appointment as the exclusive global brand-integration partner for two upcoming feature films from Tested Films: the action thriller Habeas Corpus and the neo-noir romantic mystery Blurred. Sky Blue Cinematix appointed exclusi
Here's how parents can promote a healthy diet in kids without the unnecessary friction
Netflix VP of Global Live Sports & Entertainment on WWE: "They’ve been great partners, and we’re thrilled with the results so far" - POST Wrestling | Podcasts, News, Reviews
Gabe Spitzer, a Vice President at Netflix, spoke with Richard Deitsch on the Sports Media podcast regarding their relationship with WWE.
Global report shows where US kids rank in reading, math and science
ABC News' Elizabeth Schulze has the results of a new report released this morning showing where U.S. students rank compared with students around the world.
Wimbledon refusing to credential influencers after US Open drama
Like a Biblical plague that descended upon Egypt, influencers have crashed the US Open tennis tournament in Flushing Meadows this year. The final tennis major of the season has become mostly about everything but the tennis. The US Open invited 100 influencers and content creators, nearly doubling the number invited from last year. Videos are…
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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