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Paige Bueckers, Sabrina Ionescu 'very excited' for new WNBA CBA
WNBA players like Paige Bueckers and Sabrina Ionescu are "very excited" for the new CBA, allowing the season to move forward.
Super Mario Bros. Speedrunner Lays Out Claims Of Sabotage
Speedrun.com suddenly banned his preferred input method after voting to allow it just four months prior
Texas judge rejects push to let churches make political endorsements
A federal judge in Texas has dismissed a lawsuit seeking to allow churches to endorse political candidates without losing their tax-exempt status
DI Cabinet adopts new rules to address ‘ghost transfers’ for all sports
On Wednesday, the Division I Cabinet adopted a proposal that penalizes programs that sign a transfer student-athlete, add a transfer student-athlete to a roster, or allow a transfer student-athlete to participate in athletically related activities before the student-athlete is entered into the NCAA Transfer Portal.
Arizona baseball drops midweek home game to West Virginia
It’s hard to defend free bases. Arizona pitchers struck out 16 batters and only allowed five hits on Tuesday night, but they also issued 10 walks and hit two batters in a 7-4 loss to West Virginia at Hi Corbett Field. “We gave them pretty much all seven runs,” UA coach Chip Hale said. “They […]
While some residents criticize, Jacksonville’s 3 a.m. alcohol ordinance gets praise from downtown businesses
Downtown Jacksonville’s newest ordinance allowing bars to serve alcohol until 3 a.m. has been in effect for about a month, and early signs point to a boost in business.
How squid survived Earth’s biggest extinction and took over the oceans
Scientists have finally cracked a long-standing mystery about squid and cuttlefish evolution by analyzing newly sequenced genomes alongside global datasets. The research reveals that these bizarre, intelligent creatures likely originated deep in the ocean over 100 million years ago, surviving mass extinction events by retreating into oxygen-rich deep-sea refuges. For millions of years, their evolution barely changed—until a dramatic post-extinction boom sparked rapid diversification as they moved into new shallow-water habitats.
Judge Dismisses Lawsuit That Challenged Ban on Endorsements by Churches
Conservatives had expected a victory in the case after the I.R.S. agreed to a settlement that allowed churches to voice support for candidates.
Mayor Mamdani announces return of social media app for NYC government
The city will now allow agencies to start posting again on the short-form social media site.
Judge Blocks Deal Allowing Churches to Endorse Political Candidates
The Trump administration had sought looser rules for religious groups.
Federal Judge Approves Trump Effort to Extract List of Jews From Penn
The decision to allow the government to collect the names and phone numbers of Jewish people on campus could allow the government to pursue similar tactics elsewhere.
Is Your Gmail Username Embarrassing? You Can Finally Change It
A new feature allows Google Account users in the US to update their Gmail address.
Gov. Morrisey signs bill allowing more flexible high school sports transfer rule
Transfer restrictions will remain in place for juniors and seniors under the new rule.
Airbnb Externship Shows 3L Isabel Samayoa How Legal Strategy Drives Business Growth - UC Law San Francisco (Formerly UC Hastings)
An externship at Airbnb provided 3L Isabel Samayoa exposure to areas such as contracts, licensing, risk management, and growth strategy, helping her develop the skills and experience to thrive in her future career as a corporate transactions attorney. 3L student Isabel Samayoa reflects on her work with Airbnb’s in-house legal team through UC Law SF’s Corporate Counsel Externship Program. Supported Airbnb’s legal team on commercial contracts, open-source licensing, external partnerships, product counseling, and legal research. Observed how legal advice aligns with business strategy and risk management. Gained exposure to strategic decision-making while preparing for a career in corporate transactions. Q: What did you do in this corporate externship? A: I supported the Airbnb legal team across several functions, including commercial contracts, open-source licensing matters, strategic external partnerships, legal research, real estate matters, internal AI integration, and product counseling. I also gained exposure to corporate structure counseling, litigation, patent counseling, and the company’s broader business strategy. Q: What did you take away from this experience? A: One of the most valuable parts of this experience was learning how a business actually operates. I had never worked on such a large team in the private sector, so I had little exposure to how companies run internally. I learned how lawyers can provide valuable advice to support business goals, seeing how leadership evaluates risk and develops growth strategies. Understanding those priorities allows me to calibrate my legal advice to clients, balancing the client’s goals against the level of risk they are willing to take. Q: How does this experience support your career goals? A: Exploring the anatomy of a successful company was incredibly valuable because I plan to pursue a career as a corporate transactions lawyer. Being in the room with the teams discussing important decisions allowed me to see firsthand the factors that contribute to that success and how lawyers help guide those decisions. Q: Would you recommend UC Law SF and this externship? Why? A: I would absolutely recommend this opportunity. While the team worked on high-stakes matters at a highly successful company, they still created an environment where I felt welcomed. They trusted me with meaningful work and supported me every step of the way. This helped me build confidence in my analytical abilities. Q: What’s your favorite UC Law SF memory so far? A: Some of my favorite UC Law SF memories, aside from my time at Airbnb, involve mentorship. I have benefited from mentorship and have also had the chance to mentor other law students. Watching the students I mentored go on to mentor others has been particularly rewarding. I think mentorship is integral to the legal profession, and it has been inspiring to see that culture thrive at UC Law SF and continue beyond the classroom. The Evidence of Success series highlights UC Law SF students as they share how the College’s opportunities equip them with the experience, skills, and confidence to excel in the legal profession.
Supreme Court Allows Licensed Mental Health Practitioners to…
HRC President Kelley Robinson: “To undermine protections that keep kids and families safe from these abusive practices is shocking — and our children…
McPherson College and Barton School of Business at Wichita State Launch Accelerated MBA Pathway Partnership
Wichita State University’s W. Frank Barton School of Business and McPherson College have announced a new academic partnership that will allow eligible
Kansas might serve alcohol 23/7 to boost business from World Cup partiers
A bill approved by lawmakers and headed to the governor would allow 23-hour alcohol sales for a limited time during the World Cup this summer.
Stanford scientists create shape-shifting material that changes color and texture like an octopus
A new shape-shifting material can change both its texture and color in seconds, inspired by the camouflage abilities of octopuses. By precisely controlling how a polymer swells with water, researchers can create detailed, reversible patterns at the nanoscale. The material can even mimic realistic surfaces and dynamically adjust how it reflects light. In the future, AI could allow it to automatically blend into its surroundings.
Midjourney engineer debuts open source Pretext to revolutionize web design
It allows developers to treat text as a fluid substance that can be recalculated every single frame without dropping a beat.
Trump administration sues Minnesota for allowing trans athletes in girls’ sports
Justice department claims the state is violating Title IX – the federal law that prohibits sex-based discrimination
Trump administration sues Minnesota over transgender athletes in girls sports
MINNEAPOLIS (AP) — The Trump administration sued Minnesota and its school athletics governing body on Monday, carrying out a threat to punish the state for allowing transgender athletes to compete in girls sports.
Learfield and Redbird Sports Properties To Lead ISU Athletics Jersey Patch Partner Search
In the ever-changing landscape of collegiate athletics, opportunities for revenue are at a premium and when the NCAA Division I Cabinet announced it has voted to pass the option to allow sponsored jersey patches during competition on January 23, a new opportunity was on the table. With the result of the vote, Illinois State Athletics, and Learfield's Redbird Sports Properties are working together to bring this historic opportunity for Redbird Athletics and its 17 varsity sports to the marketplace for the upcoming athletics season beginning August 1.
Every NCAA men’s Final Four team since 2016
March Madness is the most unpredictable event in American sports. Sixty-eight teams tip off with the same dream, and only four make it to the sport’s most hallowed stage, the Final Four. Since 2016, that stage has been graced by…
Philanthropy in science has little oversight. Jeffrey Epstein exploited that
A large share of science funding comes through philanthropy, with little legal or public scrutiny. This lack of oversight allowed Jeffrey Epstein to cultivate scientists and launder his reputation.
Killing off the Regional Transportation District
This column is appearing the same day state Sen. Matt Ball (D) of Denver and his legislative co-sponsors unveil legislation implementing many of the recommendations advanced by last summer’s RTD Accountability Committee. Although it isn’t readily apparent, they have allowed themselves to be enlisted in a plot that will likely lead to the bankruptcy and […]
President Trump says he has 'no problem' with allowing oil into Cuba
Trump told reporters he would allow a Russian oil tanker to resupply Cuba, which suffers an energy crisis after the U.S. halt of Venezuelan supplies.
Makers of dietary supplements push the FDA to allow peptides and other new ingredients
Makers of dietary supplements are pushing the Food and Drug Administration to expand the types of ingredients they can put in their products.
Entertainment Bill on Move in State Legislature
A House bill being considered to allow for the designations of entertainment districts in Osage Beach and Chesterfield appears to be on the move in the state Senate. Sponsored by the 123rd district…
RFK Jr. makes food sound like a miracle drug, but researchers say he often overstates the science
Robert F. Kennedy Jr. has claimed diet can "cure" schizophrenia and diabetes and allow people to rid themselves of bipolar disorder. Researchers say the comments overstate current evidence.
New LIVE program brings after-school math and science coaching to Oklahoma schools
A new kind of program is coming to oklahoma schools that will allow students to take their brainpower to the next level.
DDR5 RAM prices show rare drop amidst memory shortage after TurboQuant announcement
U.S. buyers are starting to see memory prices level off at major retailers. Amazon shoppers will find that some Corsair Vengeance DDR5 RAM is now slightly more affordable. Google’s TurboQuant algorithm may allow AI data centers to use fewer modules, increasing supply for gamers.
New Google tool allow users to scrub more personal data to keep safe from online thieves
Google is rolling out a new feature called "Results about you" to help users scrub more sensitive information such as social security and driver's license numbers from internet search results, on top...
Cottage Grove board advances sports complex project with permit approvals
The board recently approved rezoning for the property near Gaston Road along with a conditional use permit, allowing the proposed sports facility and outdoor amenities.
New rage room business in Topeka offers space to break items, relieve stress
Anger Management 785 will join spaces with Odin’s Lair and allow patrons to use bats, clubs and hammers to break objects.
Scientists discover a hidden system that turns brown fat into a calorie burner
Scientists have identified a key biological system that helps brown fat burn energy by building the networks it needs to function. A protein called SLIT3 splits into two parts, with each piece guiding the growth of blood vessels and nerves inside brown fat. These structures allow the tissue to pull in nutrients and rapidly convert them into heat instead of storing them as fat.
UCLA's Cori Close says Bruins' success has taken a toll on her
UCLA coach Cori Close is calling for reforms that allow players to be paid and transfer while also supporting worn out coaching staffs.
The Politics Hour: Fairfax County Board Chair Jeff McKay and 'Crossover Day' in Maryland
Fairfax County Board Chair Jeff McKay on Richmond voting to allow a Tysons casino. Plus, Maryland House Majority Whip Ashanti Martinez on the bills moving forward in th General Assembly.
Trump says he wants to send federalized troops to L.A., San Francisco
Trump called on the mayors and governors of several blue cities and states to allow troops to 'come in and stop the crime,' and specifically called out Los Angeles and San Francisco.
Apple will reportedly allow other AI chatbots to plug into Siri
Other AI chatbots, like Gemini or Claude, could help Siri fetch answers.
Bill to allow Philadelphia business to stay open until 4 a.m. this summer
Apple Plans to Let Rival AI Chatbots Integrate With Siri in iOS 27
Apple plans to allow third-party AI chatbots to integrate with Siri in iOS 27, reports Bloomberg. Apple already has a partnership with OpenAI that lets Siri hand questions off to ChatGPT, but Apple will expand that integration to other companies like Google and Anthropic. An iPhone user with the Claude or Gemini app installed will be able to send questions to those chatbots, like how the current ChatGPT feature works.
Opioid settlement funds designated to build 60-bed youth behavioral health facility in Anderson
The local nonprofit Family Dynamics Resource Center asked the county board for $2 million as a community match in order to receive $25 million dollars in funding from the state. The funds are intended to allow the organization, which provides counseling and parenting services, to develop a 60-bed behavioral health campus for youth.
Apple Plans to Open Up Siri to Rival AI Assistants in iOS 27 Update
(Bloomberg) -- Apple Inc. plans to open Siri to outside artificial intelligence assistants, a major move aimed at bolstering the iPhone as an AI platform.The company is preparing to make the change as part of a Siri overhaul in its upcoming iOS 27 operating system update, according to people with knowledge of the matter. The assistant can already tap into ChatGPT through a partnership with OpenAI, but Apple will now allow competing services to do the same.The changes are part of an attempt to tu
Tom Brady says he's asked NFL about potential comeback: 'They don't like that idea very much'
Tom Brady has asked the NFL about its policy of allowing minority owners to return as players, but he has no plans on returning the field, he told CNBC.
Good Morning, Nashville! Talking Immigration Data Politics at Vanderbilt University
After a busy day on Capitol Hill yesterday, I landed in Nashville, Tennessee, last night for an exciting two days on campus at Vanderbilt University. Carwil Bjork-James, an anthropologist whose creative use of database construction to support critical scholarship resonates strongly with my own work, generously invited me to give a talk today about the politics of immigration data and to join a Wikipedia edit-a-thon tomorrow on the topic of immigrant detention. I encourage you to check out Carwil’s database project “Ultimate Consequences” about political deaths in Bolivia after 1982, and his book The Sovereign Street: Making Revolution in Urban Bolivia. My talk today is titled “Untangling the Messy Politics of Immigrant Detention Data.” I’ll focus on how immigrant detention data (not just detention centers themselves) become sites of controversy—from the collection and classification choices that shape what we can know, to the strategic withholding and distortion of data for political ends. Drawing on research spanning multiple administrations, I’ll trace how current data controversies in the second Trump administration connect to long-standing tensions in how we measure, interpret, and communicate about immigration. My goal is to move beyond simple partisan narratives and offer a practical guide for anyone working with immigration data to explore both the pitfalls to avoid and the creative opportunities for more transparent, rigorous public communication about immigration realities. If you are on campus, please stop by. Tomorrow I will join Carwil and Vanderbilt students for a Wikipedia Edit-a-Thon to edit and update Wikipedia entries related to immigrant detention with the latest robust information and data. This event is designed to orient participants into how to edit on Wikipedia, provide them with data-driven starter templates on detention facilities, and allow each person to produce an initial article on one element of the network of ICE facilities or one death in custody this year. The workshop is also a demonstration of how to use open data sources to build public knowledge—something I am deeply passionate about. Thank you to Vanderbilt University, the Spatial Histories series, and Carwil for hosting me. I would love to be a part of conversations and workshops related to immigration data on your campus. Students are really eager these days to have informed, critical, and data-driven explorations of our current immigration system. Reach out anytime if you want to discuss the possibility of bringing me to your campus. Subscribe
Amazon tests Prime shipping on the web without an Amazon login
Amazon tests a new program allowing Prime shipping on external sites without an Amazon login, extending its logistics reach with other merchants.
As political winds shift, this Louisiana renewable energy venture shoots for the stars
"We've spent years figuring out how to make wind blades lighter, stronger and cheaper — and we're set up at a facility that will allow us to expand quickly into production and shipping at scale. Now we're ready to apply those strengths to booming sectors of the economy."
NBA expansion: Seattle and Las Vegas could host new teams after league board of governors vote
The NBA's board of governors vote to allow the league to explore potential expansion franchises in Seattle and Las Vegas.
States Brace for a Potential Supreme Court Ban on Late-Arriving Ballots
The court’s conservatives appear skeptical of laws allowing mail ballots to arrive after Election Day. A decision could come as late as June, potentially scrambling midterm elections.
Las Vegas and Seattle are a step closer to getting NBA teams after league’s owners approve expansion exploration
The NBA’s board of governors voted Wednesday to approve a plan that will allow NBA officials to “formally explore potential team expansion” to Seattle and Las Vegas.
Price tags for patients: I’m still fighting for honest health care transparency
The Patients Deserve Price Tags Act would provide price transparency in the health care system, allowing patients to make informed decisions about their care and reducing costs for employers and fa…
Women's game needs more respect
Chelsea manager Sonia Bompastor says the women's game needs "more respect" after her side have a goal controversially disallowed in their Women's Champions League quarter-final first leg against Arsenal.
Austin establishes microloan hub for small businesses
The city of Austin announced on Tuesday it’s teaming up with global nonprofit Kiva to launch the second Kiva hub in Texas, allowing small business owners to apply for microloans and coaching.
Brazil’s former president Bolsonaro allowed to serve 27-year sentence at home due to poor health
The decision follows Bolsonaro’s hospitalization for pneumonia, one of several health problems he has faced since he was stabbed by a man in 2018 before he was elected president.
Bolsonaro allowed to serve 27-year sentence at home due to ill health
The decision by Supreme Court Justice Alexandre de Moraes follows Bolsonaro’s hospitalization since March 13 for pneumonia.
Russia turned cheap 'Molniya' strike drones into advanced recon tools
The modifications allow Russia to use these drones for battlefield reconnaissance instead of relying on more expensive platforms.
Magic face urgency to end skid vs. rising Cavaliers
James Harden and Donovan Mitchell took turns rescuing the Cavaliers on their three-game road trip, allowing Cleveland to sweep the Milwaukee Bucks, Chicago Bulls and New Orleans Pelicans.
Someone has publicly leaked an exploit kit that can hack millions of iPhones
Leaked "DarkSword" exploits published to GitHub allow hackers and cybercriminals to target iPhone users running old versions of iOS with spyware, according to cybersecurity researchers.
Science Through Shadows: How Astronomical Alignments Reveal the Universe
When one celestial object passes in front of another, it can cast a shadow that travels across space – and sometimes across Earth. These moments of alignment, known as eclipses, occultations, and transits, allow scientists to study distant objects in remarkable ways. By observing how light changes when an object briefly blocks another, astronomers can measure sizes and shapes, detect atmospheres, and refine the orbits of asteroids and planets.
Takeaways from arguments in the Supreme Court case that could end grace periods for mail-in ballots
The Supreme Court’s conservative majority appeared dubious of state laws that allow the counting of mail ballots that arrive at election offices after Election Day as justices heard oral arguments in a challenge to Mississippi’s five-day grace period for mail ballots.
Bill introduced seeks to ban sports bets on prediction markets
A bipartisan Senate bill introduced Monday seeks to ban prediction markets from allowing transactions that mimic sports betting.
SCOTUS conservatives signal readiness to curb late-arriving mail ballots
Conservative Supreme Court justices appeared skeptical during oral arguments of allowing states to continue counting late-arriving mail-in ballots. A decision is expected in June.
Chelan Co. Sheriff’s Office secures nearly $55k in funding for behavioral health unit
The Chelan County Sheriff’s Office has secured nearly $55,000 in outside grant funding to support and expand its behavioral health crisis response program, allowing the agency to add training, equipment and other resources without using county funds.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Square Enix announces it will integrate Google’s generative AI Gemini into popular online game Dragon Quest X
Square Enix has found a use for Google’s generative AI Gemini and will be putting it to use in the popular online game, Dragon Quest X. Gemini will be used in-game as a feature that allows players to…
Inflatable homes on the Moon? Scientists reveal how humans could live there sooner than expected - Futura-Sciences
How could humans live on the Moon? Although the Artemis program has taken a more cautious approach following recent delays, the goal remains the same: send astronauts back to the lunar surface. Doing so will require systems that allow crews to stay there for several days, or even several weeks....
Arizona softball walks off ASU to even series
Arizona softball earned a walk-off win over ASU Saturday night, though not the kind the Wildcats may have been expecting through the first part of the game. Arizona jumped out to an 8-0 lead, then allowed the Sun Devils to claw all the way back before Regan Shockey delivered a walk-off single in the seventh […]
Illinois State, Wake Forest battle for NIT quarterfinal spot
Another prolific scoring performance by Juke Harris allowed Wake Forest to keep its season alive and the best game of Landon Wolf's career enabled Illinois State to continue playing.
Apple TV Is Now Almost 20 Years Old
The Apple TV is now almost two decades old amid rumors of the announcement of a new model. Today marks 19 years Apple launched the original Apple TV. Apple CEO Steve Jobs unveiled the Apple TV at Macworld Expo in January 2007 alongside the original iPhone, but it didn't launch until March. The Apple TV was initially previewed as the "iTV". The device allowed users to wirelessly stream movies, TV shows, music, and photos from their Mac or PC directly to their TV.
Downtown Chico business owner voices concerns over street closures for events
A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO { "@context": "https://schema.org", "@type": "VideoObject", "name": "Downtown Road Closure Dilemma", "description": "A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO", "thumbnailUrl": "https://bloximages.newyork1.vip.townnews.com/actionnewsnow.com/content/tncms/assets/v3/editorial/c/47/c47e26d6-03c3-5f35-bf49-37925ab603d7/69bdedc4eb57d.image.jpg", "uploadDate": "2026-03-20T17:45:00-07:00", "contentUrl": "https://cdn.field59.com/KHSL/1774053903-6e1ef36dd09fbebf020833aee86b60da3b3cca3f_fl9-720p.mp4" } CHICO, Calif. - A downtown Chico business owner is voicing concerns about the impact of street closures for events on local shops. Leann Powell, owner of The Peddler’s Closet, expressed concern about events closing down streets downtown and bringing in food trucks and other shops’ products that directly compete with the brick-and-mortar stores in downtown Chico.Powell said an upcoming event held on a Saturday has brought up concerns for her and other business owners downtown, due to it being a busy day for businesses. "We're already struggling, and then to bring in more businesses on top of our businesses and shut our streets down is absolutely devastating," said Powell.Powell noted a decline in business during events like the Thursday Night Market, where street closures allow outside vendors to set up shop. She shared that while organizers for these types of events often offer booths to local businesses, it does not alleviate the burden."I don't really feel like that's a solution because you're bringing in other businesses, you're shutting the streets down. Yes, we can go down and set up a space, but then you've gotta pay somebody to run that space, plus run your own business for the day, and it's really not, it's really not helpful for us," said Powell.Applying for a street closure permit in Chico involves approval from the Public Works Department, the Chief of Police, and the Fire Chief. Permits can be denied only under a handful of circumstances, such as interference with first responders, previously scheduled construction, or existing permits for the same space.Mayor Kasey Reynolds addressed the issue, saying the city council has tasked staff with reviewing the municipal code for street closure permits with the goal of finding ways to minimize negative impacts on local businesses during events.Reynolds mentioned that any recommended changes might require further direction from the city council, depending on the extent of any changes recommended. googletag.cmd.push(function() { googletag.display('ad-1514992'); });
WXYZ-TV sports anchor Brad Galli to leave the station
Galli posted on Facebook that he is excited about a new opportunity that he didn't name. He said it will allow him to be home more with his family.
David Botstein, Gene-Mapping Pioneer, Dies at 83
His method of locating genes in human DNA allowed researchers to find disease-causing genes, and later to map the entire, sprawling human genome.
The R.I.-based pharmacy giant also owns health insurer Aetna and pharmacy benefit manager Caremark, allowing it to control how medications are priced, prescribed, and dispensed
CVS owns health insurer Aetna and pharmacy benefit manager Caremark, allowing it to control how medications are priced, prescribed, and dispensed.
Scott Galloway: Cost of his Big Tech protest, paternity leave comments
Scott Galloway wants you to quit Big Tech. First, he had to do his own audit.
How did these flowers evolve to survive a megadrought?
A multi-year megadrought in the Western U.S. has claimed untold populations of wild plants. Amid the conditions, some have survived. Scientists have produced a stunningly complete picture about how populations of one particular flower – the scarlet monkeyflower – made it through. In a new study published in the journal Science, a team of scientists spent decades studying and sampling select populations of scarlet monkeyflowers in California and Oregon. Through genetic sequencing, the team discovered that the populations that did best went through genetic changes in a short time period. This is known as rapid evolution. The team found that three of the populations that recovered the BEST adapted their stomata to open less, so they could conserve more water. Stomata act like a plant’s pores, managing gas exchange and water loss. This allowed the scarlet monkeyflowers to hunker down in the drought and survive. Interested in more stories about rapid evolution? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Listen to Short Wave on Spotify and Apple Podcasts.This episode was produced by Jeffrey Pierre, Rachel Carlson and Hannah Chinn. It was edited by Christopher Intagliata and Rebecca Ramirez. Aru Nair checked the facts. The audio engineers were Becky Brown and Robert Rodriguez.
Trading or gambling? How a new way to wager on sports is evading Nebraska’s betting ban
Prediction markets have allowed Nebraskans to put money on everything from Husker basketball to Omaha's mayoral election. The markets say their users aren’t "betting" — they’re "trading."
Oz Says California’s Not Fighting Health Care Fraud, but Data Shows It’s Part of a Larger Battle
Trump administration officials say the state allows rampant fraud and have promised to investigate, blaming the “Russian, Armenian mafia” in the hospice and home health care industry. But data shows hotbeds of health care fraud throughout the country, with California outperforming most other states in recovering fraud dollars.
Pikl Pioneers a New Category of Insurance-Enabled Business Models, Earning it 20% UK Short-Term Rental Market Share
Pikl, the company pioneering insurance-enabled business models that drive revenue whilst protecting against downside risk, today announced that it has achieved 20% market share in the UK short-term rental market – the first industry in which its insurance-enabled growth solutions have been delivered. The achievement comes just two years after Pikl launched its flagship flexible cancellation solution in 2024, which allows property management companies (PMCs) to offer guests the flexible booking o
Hurricanes Hold On, Overcome Penguins in Milestone-Filled Game
Wednesday night, the Logan Stankoven line was fire. They were also score. …Please allow me the Evgeni Malkin puns, I […]
Thai Leader Anutin Set to Extend Rule in Vote After Election Win
Thai Prime Minister Anutin Charnvirakul is poised to win lawmaker approval for a new term less than six weeks after elections, potentially bringing stability to the country’s often volatile political landscape and allowing him to manage the fallout from the war in the Middle East.
Ski For Life: Oregon adaptive sports program opens slopes to students with disabilities
An Oregon Adaptive Sports program allows young people with disabilities to participate in outdoors sports by providing them with adaptive equipment.
Entertainment Industry Foundation Launches EIF Studios for Social Impact-Focused Content
“EIF Studios will allow us to shepherd important stories from around the world to reach an audience that can make a real impact on the outcome,” said EIF president and CEO Nicole Sexton.
Entertainment Industry Foundation Launches EIF Studios
“EIF Studios will allow us to shepherd important stories from around the world to reach an audience that can make a real impact on the outcome,” said EIF president and CEO Nicole Sexton.
Samsung Is Now Allowing Users In A Key Market To Use The Galaxy S26 Series For A Year By Paying Just 50 Percent Of The Price
Samsung Mobile is throwing everything, including the proverbial kitchen sink, to keep the sales cadence for the Galaxy S26 series elevated.
Trump waives Jones Act for 60 days in bid to free up the flow of oil to US ports
President Donald Trump temporarily waived the century-old shipping law for 60 days, allowing foreign ships to carry oil and resources between U.S. ports.
EU Inc proposal seeks to rival US in innovation by easing startup creation
The European Commission proposed on Wednesday allowing firms to set up in as little as 48 hours and operate according to a single set of rules across the 27-nation EU in a bid to narrow the gap with the United States in innovative startups.
Wisconsin lawmakers approve measure to allow tribes to offer online sports betting
MADISON, Wis. (AP) — As sports fans wager billions of dollars on the NCAA basketball tournaments, Wisconsin lawmakers are taking a shot at an expanded sports betting plan that could ...
Wisconsin lawmakers take a shot at joining the ranks of states allowing online sports betting
MADISON, Wis. (AP) — As sports fans wager billions of dollars on the NCAA basketball tournaments, Wisconsin lawmakers are taking a shot at an expanded sports betting plan that could bank big bucks for…
Cuban American business owners in South Florida react to the island's announcement to allow foreign investment
Cuban Americans Will Be Allowed to Own Businesses in Cuba, but Is That Enough?
The Cuban government announced that Cubans living abroad can own and invest in businesses, but experts said they were disappointed that the measures didn’t go further.
Bipartisan Science of Reading Bill Passes House Committee
The legislation would prevent states from allowing what one member called ‘discredited approaches.’
Kalshi charged criminally in Arizona for operating illegal gambling business
Arizona's attorney general on Tuesday filed criminal charges against Kalshi, accusing the prediction markets platform of operating an illegal gambling business in the state and unlawfully allowing people to place bets on elections.
Google's Personal Intelligence feature is expanding to all US users
Personal Intelligence allows Google's AI assistant to tap into your Google ecosystem, such as Gmail and Google Photos, to provide more tailored responses.
PR firm solo operators use AI to support their strategic services
Boutique PR agency solopreneurs use AI to streamline tasks, allowing focus on client strategy and creative work.
We work in an ICU — and see firsthand how Trump’s health care cuts are endangering Americans’ lives
Senate Republicans have deliberately allowed health insurance protections to expire to reduce federal spending, exposing a fragile system built upon temporary fixes — and leading to a growing number of tragic outcomes.
Insider’s view: how China mobilises resources nationwide to develop new weapons
The country’s military modernisation integrates civilian scientific and industrial capabilities into defence innovation allowing rapid development.
US National Academy of Sciences awards four Spaniards for explaining how life escaped an evolutionary dead end
After research spanning more than 30 years, Jordi Bascompte, Bartolo Luque, Fernando Ballesteros, and Enrique Muro managed to explain the abrupt change in living beings that allowed the appearance of plants and animals, including humans
Scientists uncover the secret timing behind glowing fireflies
Researchers have discovered the mathematical pattern that allows thousands of synchronized fireflies light up the night.
Cuba will allow nationals living abroad to invest in and own businesses on the island, economic czar tells NBC News
“Cuba is open to having a fluid commercial relationship with U.S. companies" and "also with Cubans residing in the United States and their descendants," Deputy Prime Minister Oscar Pérez-Oliva Fraga said in an interview in Havana.
Business majors preparing for the future
The third annual Arizona Statewide Business School Case Competition (ASBSCC), coming to Northern Arizona University, provides students with the opportunity to apply their knowledge and test their soft skills—communication, leadership, adaptability, networking and collaboration—by placing them in realistic business scenarios that demand quick thinking and effective teamwork. This collaborative effort between Arizona State University, the University of Arizona and NAU allows students to work across institutional lines to…