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Mills, Collins on opposite sides of trans athlete issue

Collins, who is seeking a sixth term, posted on social media over the weekend that she’s held a “longstanding position that transgender athletes should not compete in girls’ and women’s athletics.”

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Mar 23 • 1:43 PM EDT • Politics • spectrumlocalnews.com
House GOP targeting vulnerable Dems over DHS shutdown, TSA chaos

The NRCC launches paid ads targeting Democrats in 28 districts, accusing them of shutting down DHS and forcing TSA agents to work without pay at airports.

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Mar 23 • 1:35 PM EDT • Politics • foxnews.com
Intel Core Ultra 5 250K Plus Review - Disrupting AMD's Entry-Level

Intel is breathing new life into its Arrow Lake lineup with the Core Ultra 5 250K Plus. Priced at an attractive $200, this little powerhouse outperforms most AMD CPUs in applications and delivers competitive gaming performance, too. It's a strong contender for budget-friendly builds, and overclocking potential is good, too.

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Mar 23 • 12:57 PM EDT • Technology • techpowerup.com
Thousands in taxpayer funds spent on horse, hair and makeup expenses for Kristi Noem’s Mount Rushmore ad

Tens of thousands of taxpayer dollars were spent on expenses for hair and makeup artists and a horse for the advertisement showcasing outgoing Department of Homeland Security Secretary Kristi Noem in front of Mount Rushmore, according to invoices seen by CNN.

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Mar 23 • 12:51 PM EDT • Politics • cnn.com
How entertainment production hubs are creating new housing hotspots

NewHomeSource reports entertainment production hubs are driving housing demand by boosting local economies, attracting home buyers with modern amenities and community design.

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Mar 23 • 12:05 PM EDT • Entertainment • newspressnow.com
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Jude Law’s Riff Raff Entertainment hires former House exec

Georgia Ince was previously a development executive at House.

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Mar 23 • 11:20 AM EDT • Entertainment • screendaily.com
New C8 Corvette Grand Sport Makes Surprise Debut at 12 Hours of Sebring

The first mid-engined Grand Sport dons a widebody and red hashmarks, with the car's full reveal coming later this week.

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Mar 23 • 10:50 AM EDT • Sports • caranddriver.com
Revolutionary Submarine Mysteriously Disappears Without a Trace – Scientists Are Now Preparing for a Bold Return

A pioneering robotic submarine that explored beneath Antarctica’s glaciers has been lost, but its discoveries are reshaping our understanding of ice melt as a more advanced successor is prepared to continue the mission.

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Mar 23 • 10:04 AM EDT • Science • scitechdaily.com
How Healthy Are Meat Sticks and Jerky as Protein Sources?

These convenient snacks are rich in protein and low in calories, but they are considered processed meats. Here's how often you should eat them.

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Mar 23 • 8:00 AM EDT • Health • health.com
Free sports physicals return for public school students in Flagler and Volusia counties

Thousands of middle and high school students in public schools across Volusia and Flagler counties can receive free sports physicals this spring as AdventHealth helps young athletes prepare safely for the upcoming season.

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Mar 23 • 8:00 AM EDT • Sports • adventhealth.com
The debate over Trump’s mental health: ‘Malignant narcissist ’ or ‘superhuman president’?

While some warn of the danger of having someone suffering from ‘cognitive decline’ in the White House, his inner circle attributes his outbursts to his iconoclastic personality

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Mar 23 • 7:46 AM EDT • Health • english.elpais.com
‘President Trump is right’: The White House’s go-to line about Trump’s false claims

President Donald Trump’s White House spokespeople have a favorite two-step reply when reporters ask them to comment on one of Trump’s false claims.

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Mar 23 • 7:00 AM EDT • Politics • cnn.com
Browns coach Todd Monken’s strong suit is blunt honesty without the politics

Monken's authenticity and commitment are strengths, said the Southern Miss AD who hired him for his only other head-coaching job in 2013.

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Mar 23 • 7:00 AM EDT • Politics • nytimes.com
Banijay Entertainment Dials Up Global Scripted with Premium Series Mania Slate

Media and entertainment powerhouse, Banijay Entertainment, today unveils its premium scripted offering for Series Mania, showcasing a broad range of high-end drama from across its global portfolio. As the number one European studio in scripted, with more than 100 titles launching each year, the company continues to demonstrate its scale, creative strength, global reach and […]

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Mar 23 • 6:26 AM EDT • Entertainment • banijay.com
Health care advisory Chartis brings AI development engine in-house to build tools for clients

With the acquisition of artificial intelligence incubator Leap AI, Chicago-based Chartis’ health care advisers will move from making suggestions about AI to rolling up their sleeves and building custom AI solutions.

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Mar 23 • 6:15 AM EDT • Business • chicagobusiness.com
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'BTS: The Return' review: The world's biggest boy band, without a clear direction

The documentary is an intimate, surprisingly revelatory look at BTS in transition — and the complicated process of figuring out who they are now.

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Mar 23 • 6:13 AM EDT • Entertainment • sea.mashable.com
Staff revolts, secret meetings: Inside the tense fight between Mike Pence and the Heritage Foundation

Mike Pence used to dream of following two successful Donald Trump terms with his own turn in the White House.

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Mar 23 • 6:00 AM EDT • Politics • cnn.com
Berrien County Health Department will hold free hearing, vision screenings for kids

The Berrien County Health Department will offer free hearing and vision screenings for kids throughout spring break.Clinics will be held March 30 at the departm

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Mar 23 • 5:31 AM EDT • Health • wsbt.com
German men's biathlon coaches stay, women's coaches leave after flop

Tobias Reiter und Jens Filbrich have kept their jobs as coaches of Germany's men's biathlon team despite their equivalents in the women's team leaving their roles. The season which finished on Sunday was hugely disappointing for the former biathlon powerhouses, with just one Olympic bronze medal and no World Cup wins.

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Mar 23 • 5:29 AM EDT • Sports • sports.yahoo.com
Science should guide Florida’s pesticide conversations

The science on glyphosate exposure is extensive, and the levels reported in bread testing fall well below thresholds associated with harm.

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Mar 23 • 5:04 AM EDT • Science • tallahassee.com
‘They’ve Stolen the Narrative’: Black Business Leaders on the DEI Backlash

Bloomberg Businessweek convened five prominent Black executives to candidly discuss navigating the White House, rollbacks in access and the current American mood.

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Mar 23 • 5:00 AM EDT • Business • bloomberg.com
As mayoral election looms, D.C.’s business class worries about what’s next

A potential leftward shift in the wake of the pandemic and the Trump administration’s cutting of thousands of federal jobs has sparked unease in the city’s business community.

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Mar 23 • 5:00 AM EDT • Business • washingtonpost.com
The AI push in health care is deepening medicine’s trust crisis

Health care’s adoption of AI should move at the speed of trust, not investment, writes Oni Blackstock.

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Mar 23 • 4:30 AM EDT • Health • statnews.com
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The politics of disability at the Academy Awards

Throughout history, disabled bodies have been portrayed as a burden.

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Mar 23 • 4:28 AM EDT • Politics • thepanthernewspaper.org
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Opinion | Doctors should be paid to keep patients healthy

Value-based care works best when physicians lead, specialists share accountability, and long-term outcomes matter.

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Mar 23 • 3:00 AM EDT • Health • bostonglobe.com
Those who cannot live without wild things

Aldo Leopold wrote in his Sand County Almanac, “There are some who can live without wild things and some who cannot.” The collection of essays first published in 1949 was accepted by a publishing house after a steady stream of rejections. His work long outlived him as Leopold died of a heart attack while fighting […]

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Mar 23 • 2:30 AM EDT • Politics • coloradopolitics.com
Obesity report sets out vision for healthy future in Peterborough

A new obesity charter for Peterborough says authorities should look beyond individual behaviour.

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Mar 23 • 2:06 AM EDT • Health • bbc.com
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Letters: Newspapers hold a position in our democracy, unlike any other business

I read with interest Duke Truby's viewpoint about a newspaper print medium being a "business" in the strictest sense. As such, that business should cater to its customers and clients.

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Mar 23 • 1:30 AM EDT • Business • nola.com
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Costco Expands Member Offerings With Fertility Care And In Store Events

Costco Wholesale has partnered with Sesame and IVI RMA North America to offer U.S. members access to advanced fertility care with exclusive pricing and coordinated services. The retailer is also rolling out a national outdoor cooking roadshow in warehouses, featuring multiple brands and on site experiences for members. These moves extend Costco’s reach further into healthcare services and experiential retail beyond its traditional bulk merchandise model. For investors tracking...

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Mar 23 • 12:23 AM EDT • Health • finance.yahoo.com
State lawmakers debate new round of business tax cuts

Rep. Joe Sweeney, R-Salem, and Sen. Donovan Fenton, D-Keene, discussed their support and opposition to House Bill 155, which would reduce the business enterprise tax from 0.55% to 0.50%.

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Mar 22 • 11:27 PM EDT • Business • wmur.com
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'Harry Potter' star details racist 'abuse' he suffered after joining upcoming TV show

Paapa Essiedu is speaking out about on 'abuse' he's endured since being cast as Severus Snape in the 'Harry Potter' TV series: 'Nobody should have to encounter this for doing their job.'

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Mar 22 • 11:01 PM EDT • Entertainment • ew.com
The real reasons you’re still exhausted after 8 hours of sleep, according to an expert
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Mar 22 • 10:15 PM EDT • Health • nypost.com
Commentary: Keep Kentucky judges judging and leave politics to politicians

A provision in House Bill 534 would invite judicial candidates to disclose their political party affiliation and their current and past voter registration, including “communicating political values or viewpoints consistent with his or her party affiliation.”

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Mar 22 • 10:06 PM EDT • Politics • hoptownchronicle.org
Column: Accessing mental health support shouldn’t require a walk across campus

"While well-intentioned universities have developed mental health support systems, they are poorly designed to meet students’ needs."

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Mar 22 • 9:40 PM EDT • Health • dailytarheel.com
Statue of Christopher Columbus installed on White House grounds

A statue of Christopher Columbus has been erected outside of an ornate federal office building on the White House grounds — the latest sign of the Trump administration’s efforts to reshape cultural and historical representations across the nation’s capital.

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Mar 22 • 9:09 PM EDT • Politics • cnn.com
Vermont may look across borders to help bring in business

House passes bill to create sister state program for economic development.

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Mar 22 • 8:55 PM EDT • Business • wcax.com
Chelan Co. Sheriff’s Office secures nearly $55k in funding for behavioral health unit

The Chelan County Sheriff’s Office has secured nearly $55,000 in outside grant funding to support and expand its behavioral health crisis response program, allowing the agency to add training, equipment and other resources without using county funds.

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Mar 22 • 8:42 PM EDT • Health • kiro7.com
A promising fatty liver treatment may raise cancer risk

A surprising new study reveals that blocking a supposedly protective enzyme, Caspase-2, could actually backfire—raising the risk of chronic liver damage and cancer over time. Researchers found that without this enzyme, liver cells grow abnormally large and accumulate genetic damage, leading to inflammation, scarring, and eventually tumors, especially with age. While inhibiting Caspase-2 may offer short-term benefits, such as reducing fatty liver disease, the long-term consequences appear dangerous.

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Mar 22 • 8:00 PM EDT • Science • sciencedaily.com
Scientists Identified a Speech Trait That Foreshadows Cognitive Decline

A hidden signal.

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Mar 22 • 7:21 PM EDT • Science • sciencealert.com
Jason Momoa forced to evacuate as devastating storm hits Hawaii

Thousands have been ordered to flee as the archipelago faces its most intense surge of storms in two decades.

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Mar 22 • 6:00 PM EDT • Entertainment • yahoo.com
French Local Elections Are Yardstick for Far Right. Initial Results Are Mixed.

France’s municipal elections ended on Sunday evening. Full results were not expected for hours, but the first projections suggested the far right may not have made major gains.

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Mar 22 • 5:03 PM EDT • Politics • nytimes.com
Cockroaches with smart backpacks? Scientists turn insects into cyborgs to detect hidden pipeline leaks

Science News: Although the concept seems like something from science fiction, science is rapidly adopting it. Researchers have started creating ‘cyborg cockroaches,.

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Mar 22 • 4:30 PM EDT • Science • timesofindia.indiatimes.com
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Arizona vs Utah State live updates: Prediction, how to watch March Madness Round 2 game

Folks were gushing about Jerrod Calhoun and Utah State's offense in Round 1. Arizona is a whole different obstacle. Follow March Madness Round 2 game.

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Mar 22 • 4:05 PM EDT • Sports • usatoday.com
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Minnesota Wild, NHL mourn hockey writer Jessi Pierce after death in house fire

Pierce and her three children were killed in a house fire outside of Minneapolis early Saturday morning.

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Mar 22 • 3:56 PM EDT • Sports • sports.yahoo.com
Federal union says 'untrained' ICE agents shouldn't replace TSA

President Donald Trump said he would tap ICE agents to run security at US airports as unpaid TSA officers stop showing up to work.

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Mar 22 • 3:12 PM EDT • Business • businessinsider.com
Two Offseason Trades Patriots Should Have Made But Didn't

Here are two trades that the New England Patriots should have pursued this offseason but ultimately passed on.

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Mar 22 • 3:07 PM EDT • Sports • sports.yahoo.com
Israel Thought It Could Spur Rebellion Inside Iran. That Hasn’t Happened.

President Trump’s hopes that an Israeli plan to ignite an internal uprising against Iran’s theocratic government could bring the war to a swift end have so far been dashed.

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Mar 22 • 2:45 PM EDT • Politics • nytimes.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Oil prices face new pressure as US and Iran trade threats

Trump said the US would attack Iran's power plants if it didn't reopen the Strait of Hormuz in 48 hours. Iran responded on Sunday with is own threats.

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Mar 22 • 12:11 PM EDT • Business • businessinsider.com
30 Must-Have Gadgets For Every Room In Your House

Prepare to power up your homes, my friends!

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Mar 22 • 12:01 PM EDT • Technology • buzzfeed.com
Home health aides epitomize a key problem in the current job market

About 4 million people were employed as home health and personal care aides in 2024. They earn just $16.78 an hour, despite the need for their services being intense.

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Mar 22 • 11:30 AM EDT • Health • finance.yahoo.com
Tom Steyer explains why he should be California's next governor

Tom Steyer sat down for an interview with California Politics 360 for a wide-ranging conversation on his run to be the state's next governor.

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Mar 22 • 11:25 AM EDT • Politics • kcra.com
Team USA flag football team should consider these 12 NFL stars ... but not Tom Brady

These NFL players should consider making a run at Team USA inclusion in order to earn the first football gold medal in Olympics history.

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Mar 22 • 11:18 AM EDT • Sports • usatoday.com
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‘You lose yourself’: inside the mental health crisis hitting gen X women

My generation had great role models, free university and the morning-after pill. We should be running the world. Instead, two-thirds of us are facing mental health problems – and it’s not all about the menopause

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Mar 22 • 11:00 AM EDT • Health • theguardian.com
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If Mike Johnson Goes, Who Runs House GOP?

The possibility of losing the majority in the midterms has put the Republican spotlight back on Steve Scalise, Jim Jordan and Tom Emmer.

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Mar 22 • 10:48 AM EDT • Politics • wsj.com
‘Trump should keep his reckless mouth shut’: Jeffries responds to Trump calling Democrats America’s ‘greatest enemy’
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Mar 22 • 10:43 AM EDT • Politics • cnn.com
It’s time to take politics out of the Small Business Administration

The White House’s politicization of the agency will have a real-world impact on small business owners in the US

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Mar 22 • 10:00 AM EDT • Business • theguardian.com
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It’s time to take politics out of the Small Business Administration

The White House’s politicization of the agency will have a real-world impact on small business owners in the US

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Mar 22 • 10:00 AM EDT • Politics • theguardian.com
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I took an in-person Peleton class with Jess King. Here's how it went.

I took an in-person Peloton cycling class with Jess King. I liked how thought-out the experience was.

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Mar 22 • 9:42 AM EDT • Business • businessinsider.com
Drew Barrymore says talk show audience member once criticized her dating profile

Drew Barrymore is remembering the time an audience member on her talk show gave his honest thoughts about her dating profile: 'I would probably run away.'

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Mar 22 • 9:30 AM EDT • Entertainment • ew.com
‘The Comeback’ took on Hollywood long before ‘The Studio.’ Now, Valerie Cherish will have her curtain call

“The Comeback” was by no means the first series to hold a funhouse mirror up to the entertainment industry, but the comedy starring co-creator Lisa Kudrow, which returns for its final season on Sunday, has certainly always done it in its own navel-gazing yet endearing way.

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Mar 22 • 8:00 AM EDT • Entertainment • cnn.com
Scientists twisted a mysterious superconductor and got a shocking result

A decades-old superconducting mystery just took a surprising turn. Strontium ruthenate, a material that conducts electricity with zero resistance at low temperatures, has long puzzled scientists with hints of an exotic, complex superconducting state. But by carefully twisting and distorting ultra-thin crystals, researchers found something unexpected: the material barely reacted at all. This challenges years of assumptions and suggests its behavior may be far simpler—or far stranger—than previously thought.

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Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
Pompey's hopes of staying up now unsure

BBC Radio Solent commentator Andrew Moon gives his thoughts following Portsmouth's 6-1 defeat at Queens Park Rangers in the Championship.

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Mar 22 • 7:50 AM EDT • Sports • sports.yahoo.com
Inflatable homes on the Moon? Scientists reveal how humans could live there sooner than expected - Futura-Sciences

How could humans live on the Moon? Although the Artemis program has taken a more cautious approach following recent delays, the goal remains the same: send astronauts back to the lunar surface. Doing so will require systems that allow crews to stay there for several days, or even several weeks....

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Mar 22 • 7:00 AM EDT • Science • futura-sciences.com
Lancaster County public sales: March 22, 2026

Beiler-Campbell Auction Services conducted a public auction of real estate March 9 for Stanley and Debora Miller at 2788 N. Colebrook Road, Manheim. A four-bedroom house with attached garage and

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Mar 22 • 7:00 AM EDT • Business • lancasteronline.com
White House navigates vaccine politics, midterm risks in CDC director search

The Trump administration faces complicated political dynamics as it seeks someone to helm the key public health agency suffering a prolonged leadership vacuum.

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Mar 22 • 6:00 AM EDT • Health • washingtonpost.com
White House navigates vaccine politics, midterm risks in CDC director search

The Trump administration faces complicated political dynamics as it seeks someone to helm the key public health agency suffering a prolonged leadership vacuum.

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Mar 22 • 6:00 AM EDT • Politics • washingtonpost.com
Ron DeSantis says politics should be more than 'sugar high' entertainment

'If it's not leaving something that is durable, then it doesn't matter.'

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Mar 22 • 5:45 AM EDT • Politics • floridapolitics.com
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Ron DeSantis says politics should be more than 'sugar high' entertainment

'If it's not leaving something that is durable, then it doesn't matter.'

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Mar 22 • 5:45 AM EDT • Entertainment • floridapolitics.com
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Federal employee retired, works at TJ Maxx; feels happy, less stress

Karime Masson thought she'd keep working for the Social Security Administration until she was at least 62. But after a tough 2025, she retired early.

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Mar 22 • 5:05 AM EDT • Business • businessinsider.com
AI may be helping more people start their own businesses, but without many employees

The 21-year-old cofounders of one startup said they are bringing in $1 million per month with 13 employees thanks to AI.

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Mar 22 • 5:03 AM EDT • Business • fortune.com
The Supreme Court Could Make it Harder to Vote by Mail in the Midterms

The Republican National Committee wants to toss ballots arriving after Election Day. Critics say thousands of votes — a majority cast by Democrats — are at stake.

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Mar 22 • 5:00 AM EDT • Politics • nytimes.com
Barricade That Kept Out the Far Right in France Is Crumbling

Franck Leclere made his way through the timber-framed houses of Chalons-en-Champagne and joined a crowd of people in symbolic white shirts to demonstrate against the rise of the far right in France.

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Mar 22 • 3:15 AM EDT • Politics • bloomberg.com
Can Manchester City's Guehi play in EFL Cup final?

Manchester City will be without a key defender for Sunday's final at Wembley against Arsenal.

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Mar 22 • 3:04 AM EDT • Sports • sports.yahoo.com
OPEN THREAD

The Daily Merengue is a place where you can feel free to discuss all things football. Do not be alarmed by the overt RMCF bias. It’s in the name! Shoutout to the mods who do a fantastic job Kung_Fu_Zizou, Juninho, NeRObutBlanco, Felipejack, Ezek Ix and yours truly, Valyrian Steel. Gameday!! Huge clash in the context […]

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Mar 22 • 2:39 AM EDT • Sports • sports.yahoo.com
Arizona softball walks off ASU to even series

Arizona softball earned a walk-off win over ASU Saturday night, though not the kind the Wildcats may have been expecting through the first part of the game. Arizona jumped out to an 8-0 lead, then allowed the Sun Devils to claw all the way back before Regan Shockey delivered a walk-off single in the seventh […]

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Mar 22 • 1:10 AM EDT • Sports • sports.yahoo.com
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NCAA tournament takeaways, Day 3: Big Ten reigns supreme, 'Cinderella' Texas and an extra edge for Houston
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Mar 22 • 12:44 AM EDT • Sports • sports.yahoo.com
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France Is Voting for Thousands of New Mayors. Here’s Why It Matters.

The far-right party had first-round successes in several cities, but so did the far left. Sunday’s second round may clarify who has real momentum.

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Mar 22 • 12:01 AM EDT • Politics • nytimes.com
Bloodstained: The Scarlet Engagement listed for Nintendo Switch, plus an unannounced 505 Games Switch 2 title

Bloodstained: The Scarlet Engagement has been listed for Nintendo Switch alongside an unannounced Switch 2 title from 505 Games. The Scarlet Engagement, a sequel to the original, was previously announced last year. Although there wasn’t any news about a Nintendo release, the latest discovery suggests that we’ll be getting it on Switch at the very least. It’d be somewhat surprising...

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Mar 22 • 12:00 AM EDT • Technology • nintendoeverything.com
GALLERY: Moments from Iowa State’s 9-7 win over Houston

GALLERY: Moments from Iowa State’s 9-7 win over Houston

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Mar 21 • 11:50 PM EDT • Sports • sports.yahoo.com
COLUMN: Frager punches Nebraska men’s basketball’s ticket to Sweet 16

Yes, this is real. It isn’t a dream or a movie. The Huskers are moving on to the Sweet 16 in Houston next week.

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Mar 21 • 8:10 PM EDT • Sports • dailynebraskan.com
Friction without contact discovered as magnetic forces break a 300-year-old law

Researchers have uncovered friction without contact—driven entirely by magnetic interactions. As two magnetic layers slide, their internal forces compete, causing constant rearrangements that dramatically increase resistance at certain distances. This creates a surprising peak in friction instead of a steady rise, breaking a long-standing physics law.

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Mar 21 • 8:00 PM EDT • Science • sciencedaily.com
Webb Telescope spots “impossible” atmosphere on ancient super Earth

Astronomers have uncovered surprising evidence of a thick atmosphere surrounding TOI-561 b, a scorching, fast-orbiting rocky planet once thought too extreme to hold onto any gas. Using NASA’s James Webb Space Telescope, researchers found the planet is far cooler than expected for a bare rock, hinting at a heat-distributing atmosphere above a churning magma ocean. This strange world—where a year lasts just over 10 hours and one side is locked in eternal daylight—may even be rich in volatile materials, behaving like a “wet lava ball.”

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Mar 21 • 8:00 PM EDT • Science • sciencedaily.com
‘They want to colonise us’: Brazil’s Lula warns of foreign interference

The left-wing Brazilian president is critical of US actions throughout Latin America, though he does not name Trump.

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Mar 21 • 7:35 PM EDT • Politics • aljazeera.com
PSN Service Returning on PS5, PS4 as Brief Outage Took Service Offline

Taken offline for roughly two hours

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Mar 21 • 5:00 PM EDT • Technology • pushsquare.com
Sony PlayStation Network down: PS5 users report widespread server issues; 'please fix it'

Sony PlayStation Network appeared to be down for thousands on Saturday as many flocked to social media to voice their complaints. | World News

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Mar 21 • 4:35 PM EDT • Technology • hindustantimes.com
ESP32: When Is A P4 A P4, But Not The P4 You Thought It Was

We’re used to electronic parts of the same type staying predictably the same, sometimes over many years. An early Z80 from the mid 1970s can be exchanged with one from the end of production a…

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Mar 21 • 4:00 PM EDT • Technology • hackaday.com
Young scientists shine at Regional Science Olympiad

Budding young scientists from throughout the region participated in the 41st Annual Stanislaus County Regional Science Olympiad on March 14 at Modesto Junior College.

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Mar 21 • 2:20 PM EDT • Science • turlockjournal.com
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How do I share a mental health diagnosis? | The therapist is in

Is there a way to share a mental health diagnosis but shield myself from hurt or judgment? How can I do it without changing a relationship?

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Mar 21 • 1:00 PM EDT • Health • seattletimes.com
Hundreds of Thousands of Czechs Rally in Anti-Government Protest

Hundreds of thousands of people rallied in the Czech capital of Prague in a demonstration against the cabinet led by billionaire Prime Minister Andrej Babis.

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Mar 21 • 12:40 PM EDT • Politics • bloomberg.com
Thousands race around sports complex for Phillies Charities 5K ahead of Opening Day
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Mar 21 • 12:27 PM EDT • Sports • cbsnews.com
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Farmers and rural community members can access free mental health resources

KGAN CBS 2 and KFXA Fox 28 provide local news, weather forecasts, notices of events and items of interest in the community, sports and entertainment programming for Cedar Rapids and nearby towns and communities in the Corridor and throughout eastern Iowa, including Iowa City, Waterloo, Dubuque, North Liberty, Coralville, Marion, Morengo, Williamsburg, Washington, Tiffin, Tipton, Solon, Mount Vernon, Lisbon, Central City, Urbana, Independence, Manchester, Dyersville, Oelwein, Cedar Falls, Waverly, Evansdale, Guttenberg, West Union, New Hampton, Decorah, Waukon, Maquoketa, Sigourney, Fairfield, Grundy Center, La Porte City, Dysart, Fayette, Elkader, Strawberry Point and Belle Plaine.

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Mar 21 • 12:14 PM EDT • Health • cbs2iowa.com
Local Business Spotlight: Educational Foundation of AACPS

The Education Foundation of Anne Arundel County Public Schools is helping bridge gaps, support innovation, and create new opportunities for students and educators throughout the county. In this wee…

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Mar 21 • 12:00 PM EDT • Business • eyeonannapolis.net
ChatGPT Took a Science Exam Designed by College Professors and Scored a Low D, and That Should Worry You

Confident. Clear. But a new study suggests ChatGPT's polished tone might be masking something far more troubling about how it actually reasons.

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Mar 21 • 10:30 AM EDT • Science • indiandefencereview.com
Should you try the 75 Hard challenge? Experts warn the risks may outweigh the benefits

The 75 Hard regimen demands 75 days of strict rules covering diet, exercise and reading. Experts explain what helps, what harms and smarter, sustainable alternatives.

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Mar 21 • 10:00 AM EDT • Health • cnn.com
Tom Kean Jr.'s political roots date to 1776. Is that enough to protect the Republican's House seat?

Tom Kean Jr.’s bid for a third term representing New Jersey’s 7th Congressional District offers a window into the larger battle for control of the narrowly divided House

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Mar 21 • 8:21 AM EDT • Politics • washingtonpost.com
Tom Kean Jr.'s political roots date to 1776. Is that enough to protect the Republican's House seat?

Tom Kean Jr.'s bid for a third term representing New Jersey's 7th Congressional District offers a window into the larger battle for control of the narrowly divided House. Kean and other Republicans...

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Mar 21 • 8:20 AM EDT • Politics • sfgate.com
Fort Collins' former Sundance building has a new owner. What we know

After closing its doors on East Mulberry Street in July 2024, the longtime home of Sundance Steakhouse & Saloon officially has a new owner.

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Mar 21 • 7:01 AM EDT • Business • coloradoan.com
Letters to Sports: WBC brings joy back to All-Star-level play

Readers of the Los Angeles Times Sports section give their thoughts and opinions on the World Baseball Classic, Shohei Ohtani and the Lakers.

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Mar 21 • 7:00 AM EDT • Sports • latimes.com
Woman, from Large Filipino Family That Loves Food, Thought Health Issues Were Caused by Her Diet. They Weren't (Exclusive)

A woman thought her health issues were caused by her diet, growing up in 'a big Filipino American family, where food is often the center of all gatherings.' However, Jamie Nangpi Harris' ailments were tied to Crohn's disease, a chronic, autoimmune-driven inflammatory bowel disease (IBD) that affects the digestive tract, she tells PEOPLE exclusively.

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Mar 21 • 5:06 AM EDT • Health • people.com